a_re106

Reaction transcription a_re106 map

gMCL1@Nucleus map rMCL1@Nucleus map

Reaction regulators:

Catalysis
  1. STAT5*@Nucleus map
  2. STAT3|​S727_unk@Nucleus map
Unknown_inhibition
  1. p53*|​S15_pho|​active@Nucleus map



References
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1

Confidence
REF=3 FUNC=4


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