a_re1046

Reaction state_transition a_re1046 map

STK11|​K48_unk@Nucleus map STK11|​K48_unk|​T366_pho@Nucleus map

Reaction regulators:

Catalysis
  1. DNA-PK*|​unk@Nucleus map
  2. ATM|​S1981_pho|​K3016_ace@Site of DNA damage map



References
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.

Confidence
REF=2 FUNC=5


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