a2b1*_a3b1*

Protein a2b1*_a3b1* map

Identifiers
a2b1*_a3b1*
NAME:a2b1*
ITGA2/ITGB1
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
CD49B
HUGO:ITGA2 HGNC:6137 ENTREZ:3673 UNIPROT:P17301 GENECARDS:ITGA2 REACTOME:57563 KEGG:3673 ATLASONC:GC_ITGA2 WIKI:ITGA2
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1 HGNC:6153 ENTREZ:3688 UNIPROT:P05556 GENECARDS:ITGB1 REACTOME:57597 KEGG:3688 ATLASONC:GC_ITGB1 WIKI:ITGB1
NAME:a3b1*
ITGA3/ITGB1
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
“antigen identified by monoclonal antibody J143″, MSK18
HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:22118458
Integrin a2b1 predominantly binds to fibrillar collagen
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens

a2b1*_a3b1*@Extracellular space

References
e_re907( EMT  map ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.


Modifications:
In compartment: Extracellular space
  1. a2b1*_a3b1*@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. COL4A1:​a2b1*_a3b1*@Extracellular space map

  2. Laminin1*:​a2b1*_a3b1*@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. a2b1*_a3b1*@Extracellular space map map ITGA2:​ITGB1@Cytoplasm map

  2. a2b1*_a3b1*@Extracellular space map map ITGA3:​ITGB1@Cytoplasm map
  3. a2b1*_a3b1*@Extracellular space map + COL4A1@Cytoplasm map map COL4A1:​a2b1*_a3b1*@Extracellular space map
  4. a2b1*_a3b1*@Extracellular space map + Laminin1*@Extracellular space map map Laminin1*:​a2b1*_a3b1*@Extracellular space map
  5. Laminin1*:​a2b1*_a3b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
  6. COL4A1:​a2b1*_a3b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

As Catalyser:

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