_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*

Protein _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4* map

Identifiers
_beta_-Catenin*_p120*_JUP_PKP4*
catenin (cadherin-associated protein), beta 1, 88kDa
HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1
catenin (cadherin-associated protein), delta 1
HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1
junction plakoglobin
“catenin (cadherin-associated protein), gamma 80kDa”, CTNNG
HUGO:JUP HGNC:6207 ENTREZ:3728 UNIPROT:P14923 GENECARDS:JUP REACTOME:61798 KEGG:3728 ATLASONC:GC_JUP WIKI:JUP
plakophilin 4
HUGO:PKP4 HGNC:9026 ENTREZ:8502 UNIPROT:Q99569 GENECARDS:PKP4 KEGG:8502 WIKI:PKP4

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / DESMOSOMES  map

References
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm

References
e_re1006( EMT  map ):
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)


Modifications:
In compartment: Cytoplasm
  1. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. VE-Cadherin*@Cytoplasm map + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

  2. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map Desmosomes@Cytoplasm map
  3. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map Plakophilin4*@Cytoplasm map
  4. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map Plakoglobin*@Cytoplasm map
  5. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map p120*@Cytoplasm map
  6. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map

As Catalyser:

    Leave a Reply