_beta_-Catenin*

Protein _beta_-Catenin* map

Identifiers
catenin (cadherin-associated protein), beta 1, 88kDa
HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1
“catenin (cadherin-associated protein) beta 1 (88kD)” CTNNB
catenin (cadherin-associated protein) beta 1
armadillo, beta-catenin

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:7542250
Whereas in the normal cells CTNNB1 (beta-catenin) is found in association with E-cadherin, p120 Cas is not. In the ras-transformed cells, the situation is reversed; tyrosine-phosphorylated p120 Cas, but not tyrosine-phosphorylated CTNNB1, now is detected in E-cadherin complexes.
The tyrosine-phosphorylated CTNNB1 also shows increased detergent solubility, suggesting a decreased association with the actin cytoskeleton.
decreased tyrosine phosphorylation of CTNNB1 is accompanied by increased interaction with both E-cadherin and the detergent insoluble cytoskeletal fraction
PMID:12051714
Activation of the canonical Wnt signalling pathway results in stabilisation and nuclear translocation of b-catenin.
In the absence of a Wnt signal, b-catenin is phosphorylated at four conserved serine and threonine residues at the N-terminus of the protein, which results in b-catenin ubiquitination and proteasome-dependent degradation.
The phosphorylation of 3 of these residues, Thr41, Ser37, and Ser33, is mediated by glycogen synthase kinase-3 (GSK-3) in a sequential manner, beginning from the C-terminal Thr41.
It has been shown that the GSK-3 dependent phosphorylation of b-catenin requires prior priming through phosphorylation of Ser45
GSK-3b was found to be unable to phosphorylate b-catenin at Ser45 in vitro and in intact cells.
In vitro, CK1, but not CK2, phosphorylates Ser45. Ser45 phosphorylation in intact cells is not mediated by CK1e, a known positive regulator of Wnt signalling.
PMID:11955436
Wnt regulation of b-catenin degradation is essential for development and carcinogenesis.
b-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation.
This phosphorylation is believed to be performed by GSK3B in complex with tumor suppressor proteins Axin and APC.
There is another Axin-associated kinase, whose phosphorylation of b-catenin precedes and is required for subsequent GSK-3 phosphorylation of b-catenin.
This priming kinase is casein kinase I, alpha (CSNK1A1).
PMID:11967263
Tyr-216 phosphorylation in GSK3B is required for GSK-mediated down-regulation of b-catenin activity.
PMID:8666229
Xenopus GSK3 functions to destabilize b-catenin and thus decrease the amount of b-catenin available for signaling
PMID:19619488
ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex.
Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled).
PMID:16039586 PMID:16039586
PMID:17143292
PMID:23343194

_beta_-Catenin*@Cytoplasm

References
e_re527( EMT  map ):
PMID:19751508
PMID:22270359
PMID:16940750
-In the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
-In the presence of Wnt lignads, upon ligand binding, DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs
PMID:19020303
When Wnt binds its receptor, Frizzled, beta-catenin is released to translocate from the cytoplasm to the nucleus, where it forms a complex with TCF and/or LEF transcription factors and stimulates cyclin D1 gene transcription
(Beta-catenin/TCF)- mediated cyclin D1 gene transcription is further regulated by active Rac signaling, phosphorylation by protein kinase A (PKA)
PMID:15377999
Rac1-GTP augments nuclear accumulation of b-catenin and physical association of Rac1 with b-catenin and/or TCF-4 may facilitate this process.
This culminates in the amplification of b-catenin signaling activity, resulting in enhanced transcriptional activation of perhaps a specific subset of Wnt target genes important in cancer progression.
e_re1010( EMT  map ):
PMID:10593980
PMID:12123611
Phosphorylation of CTNNB1 at Y654 by SRC prevents the interaction between Cadherin and CTNNB1.
This phosphorylation therefore reduces adhesive function.
e_re1022( EMT  map ):
PMID:15609097
CTNNB1 (beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail.
Cadherin recruits CTNNA1 (alpha-catenin) to the complex.
CTNNA1 (alpha-catenin) binds to Actin filaments directly
CTNNA1 (alpha-catenin) and can also associate with other actin-binding proteins (MLLT4 or Formin)
CTNND1 (delta-catenin or p120) binds directly to Cadherin independently of the other catenins.
Catenins/Cadherin complex can further interact with a range of singaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics.
Stability of Cadherin/Catenins complex and thereby the integrity of adherens junctions is controlled by phosphorylation/dephosphorylation.
e_re1328:( EMT  map ) PMID:21841793

_beta_-Catenin*|​pho@Cytoplasm

References
e_re1010( EMT  map ):
PMID:10593980
PMID:12123611
Phosphorylation of CTNNB1 at Y654 by SRC prevents the interaction between Cadherin and CTNNB1.
This phosphorylation therefore reduces adhesive function.

_beta_-Catenin*@Nucleus

References
s_shh2_re119:( Survival  map ) PMID:17297467

_beta_-Catenin*@Nucleus

References
s_mpk1_re106( Survival  map ):
Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled).
PMID:16039586
s_wca3_re3( Survival  map ):
Upon wnt signalling beta-catenin is not degraded and can enter the nucleus
BCL9 and PYGO stimulate translocation of b-catenin.
PMID:15208637
No active transport of b-catenin localisation of b-catenin by retention of the binding partners
PMID:16554443
s_mpk1_re107( Survival  map ):
In the presence of wnt signals (+wnt) the cytosolic amount of b-catenin increases and thus translocates to the nucleus where it associates with transcription factors of the TCF/ LEF family. Due to its transactivating ability the b-catenin-transcription-factor-co mplex binds to DNA and activates wnt target genes.
http://www.gene-regulation.com/info/b-catenin.html
s_wca3_re15( Survival  map ):
Acetylation of beta-catenin increases its stability
PMID:18987336
s_wca3_re67:( Survival  map ) PMID:19000719
s_wca3_re73:( Survival  map ) PMID:19383900
s_wca3_re88:( Survival  map ) PMID:10984057 PMID:11263497
s_wca3_re144( Survival  map ):
This complex does not contain HDAC but do contain LEF1
PMID:17666529
s_wca3_re149( Survival  map ):
HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first
PMID:20307497

_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm

References
s_wca1_re49:( Survival  map ) PMID:19576224

_beta_-Catenin*|​Y654_pho@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re40:( Survival  map ) PMID:22203675
s_wca2_re69:( Survival  map ) PMID:22370635
s_wca2_re42( Survival  map ):
Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM)
PMID:22203675

_beta_-Catenin*|​Y654_pho@Nucleus

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re42( Survival  map ):
Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM)
PMID:22203675
s_wca2_re47:( Survival  map ) PMID:19104148

_beta_-Catenin*|​K394_ubi@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re62:( Survival  map ) PMID:22705350
s_wca2_re63( Survival  map ):
Ubiquination at this residue increases b-catenin protein stability and increased top-flash activity
PMID:22705350

_beta_-Catenin*|​ace@Nucleus

References
s_wca3_re15( Survival  map ):
Acetylation of beta-catenin increases its stability
PMID:18987336

_beta_-Catenin*|​pho|​pho@Nucleus

References
s_wca3_re149( Survival  map ):
HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first
PMID:20307497

_beta_-Catenin*|​S522_pho@Cytoplasm

References
s_wnc1_re2( Survival  map ):
PMID:21506126
Phosphorylation of beta-catenin is through an indirect mechanism which is unknown
PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE

_beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm

References
s_wnc1_re17:( Survival  map ) PMID:21303971
s_wnc1_re3( Survival  map ):
PMID:21506126
This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active
PMID:16476742

_beta_-Catenin*|​S522_pho|​S675_pho@Nucleus

References
s_wnc1_re3( Survival  map ):
PMID:21506126
This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active
PMID:16476742
s_wnc1_re52( Survival  map ):
This phosphorylated form of b-catenin facilitates interaction between b-catenin and CBP
s_s_wnc1_re52( Survival  map ):

_beta_-Catenin*|​S552_pho@Cytoplasm

References
s_wnc2_re4( Survival  map ):
PMID:21506126, PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway
Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown
PMID:22094462

_beta_-Catenin*|​Y142_pho@Cytoplasm

References
s_wnc4_re5:( Survival  map ) PMID:16099633
s_wnc4_re7( Survival  map ):
B-catenin phosphorylated at this residues shows increased binding with Bcl9 (mouse homologue Bcl9-2)
PMID:15371335
Apperently Bcl9 binds b-catenin independently of Y142
PMID:17113272


Modifications:
In compartment: Cytoplasm
  1. _beta_-Catenin*@Cytoplasm map

  2. _beta_-Catenin*|​pho@Cytoplasm map
  3. _beta_-Catenin*|​K394_ubi@Cytoplasm map
  4. _beta_-Catenin*|​S522_pho@Cytoplasm map
  5. _beta_-Catenin*|​S552_pho@Cytoplasm map
  6. _beta_-Catenin*|​Y142_pho@Cytoplasm map
  7. _beta_-Catenin*|​Y654_pho@Cytoplasm map
  8. _beta_-Catenin*|​S552_pho|​pho@Cytoplasm map
  9. _beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm map
  10. _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map

In compartment: Neighbouring Cell

  1. _beta_-Catenin*@Neighbouring Cell map

In compartment: Nucleus

  1. _beta_-Catenin*@Nucleus map

  2. _beta_-Catenin*@Nucleus map
  3. _beta_-Catenin*@Nucleus map
  4. _beta_-Catenin*|​ace@Nucleus map
  5. _beta_-Catenin*|​Y654_pho@Nucleus map
  6. _beta_-Catenin*|​pho|​pho@Nucleus map
  7. _beta_-Catenin*|​S522_pho|​S675_pho@Nucleus map

In compartment: Protrusion

  1. _beta_-Catenin*@Protrusion map

Participates in complexes:
In compartment: Cilium

  1. JBN*:​_beta_-Catenin*@Cilium map

In compartment: Cytoplasm

  1. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm map

  2. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map
  3. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map
  4. Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map
  5. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytoplasm map
  6. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytoplasm map
  7. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map
  8. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map
  9. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm map
  10. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm map
  11. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm map
  12. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  13. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map
  14. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  15. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  16. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  17. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  18. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  19. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  20. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map

In compartment: Endosome

  1. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map

  2. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map

In compartment: Lysosome

  1. NOTCH1:​NUMB:​_beta_-Catenin*@Lysosome map

In compartment: Nucleus

  1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map

  2. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus map
  3. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
  4. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map
  5. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  6. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  7. BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  8. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  9. BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  10. BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  11. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  12. BCL9:​CTBP*:​KLF4:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​ace@Nucleus map
  13. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  14. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  15. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map
  16. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​pho@Cytoplasm map

  2. _beta_-Catenin*@Cytoplasm map + (APC|​pho:​AXIN1|​pho)|​active@Cytoplasm map map APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytoplasm map
  3. Catenin*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map
  4. _beta_-Catenin*@Cytoplasm map + Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map map Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map
  5. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map
  6. Plakophilin2 binding partners*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map
  7. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map map Adherens junctions@Cytoplasm map
  8. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map + Cadherin*:​p120*@Cytoplasm map map Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map
  9. r_beta_-Catenin*@Nucleus map map _beta_-Catenin*@Cytoplasm map
  10. JAG1|​ubi:​NOTCH1@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + NUMB@Cytoplasm map map NOTCH1:​NUMB:​_beta_-Catenin*@Lysosome map
  11. NICD co-factors*@Nucleus map map _beta_-Catenin*@Cytoplasm map
  12. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytoplasm map map APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map
  13. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map map degraded
  14. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytoplasm map map APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytoplasm map
  15. LEF1_TCF3_4*@Nucleus map + _beta_-Catenin*@Cytoplasm map map LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
  16. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​pho@Cytoplasm map
  17. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*@Nucleus map
  18. _beta_-Catenin*@Nucleus map + LEF_TCF*@Nucleus map map s_s_mpk1_s1019
  19. LEF_TCF*@Nucleus map + _beta_-Catenin*@Nucleus map + gpromoter_region@Nucleus map map LEF_TCF*:​promoter_region@Nucleus map
  20. _beta_-Catenin*@Nucleus map + GLI3-83_sub_TRUNC_endsub_*@Nucleus map map s_s_shh2_s195
  21. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*@Nucleus map
  22. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + _beta_-Catenin*@Cytoplasm map map AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  23. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  24. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map map AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm map
  25. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map map AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  26. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map
  27. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map map PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  28. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm map map AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm map
  29. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm map map AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm map
  30. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + E1*:​FAF*:​NEDD8:​RAD6*:​SKP*@Cytoplasm map + CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  31. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map map CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​NEDD8:​PKD*:​RAD6*:​SKP*:​USP15@Cytoplasm map + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  32. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm map map AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  33. _beta_-Catenin*@Cytoplasm map + JBN*@Cytoplasm map map s_s_wca1_s758
  34. s_s_wca1_s758 map JBN*:​_beta_-Catenin*@Cilium map
  35. JBN*:​_beta_-Catenin*@Cilium map map s_s_wca1_s764
  36. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  37. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  38. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  39. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  40. _beta_-Catenin*@Cytoplasm map + NKD1@Cytoplasm map map s_s_wca2_s5
  41. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​TGFB1:​TGFBR*@Cytoplasm map map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  42. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​Y654_pho@Cytoplasm map
  43. _beta_-Catenin*|​Y654_pho@Cytoplasm map map _beta_-Catenin*|​Y654_pho@Nucleus map
  44. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus map map TCF_LEF transcriptional_br_regulation@Nucleus map
  45. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus map map EMT@Nucleus map
  46. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
  47. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  48. _beta_-Catenin*|​Y654_pho@Nucleus map + SMAD2|​pho@Nucleus map map SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus map
  49. ECM or cell-cell contact@default map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map + p120*@Cytoplasm map + ITGA3@Cytoplasm map + Cytoskeleton@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map map Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact@Cytoplasm map
  50. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​pho@Cytoplasm map
  51. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​K394_ubi@Cytoplasm map
  52. _beta_-Catenin*|​K394_ubi@Cytoplasm map map WNT canonical pathway@Cytoplasm map
  53. ITGA9@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map map s_s_wca2_s265
  54. s_s_wca2_s265 map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map
  55. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map map s_s_wca2_s280 + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  56. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map + p300*@Nucleus map map BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  57. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  58. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + CTBP*:​p300*@Nucleus map + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map
  59. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map + CBP*|​S92_pho@Nucleus map map BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  60. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm map
  61. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm map map Degradation complex WNT canoncical pathway@Cytoplasm map
  62. KLF8@Nucleus map + BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map + p300*@Nucleus map map BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  63. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  64. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  65. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map map BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  66. KLF4@Nucleus map + BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map + LEF_TCF*@Nucleus map + CTBP*@Nucleus map + gWRE*@Nucleus map map BCL9:​CTBP*:​KLF4:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​ace@Nucleus map
  67. _beta_-Catenin*@Nucleus map + HIPK2@Nucleus map + CTBP*@Nucleus map + LEF_TCF*@Nucleus map map CTBP*:​HIPK2:​LEF_TCF*@Nucleus map
  68. _beta_-Catenin*@Nucleus map map _beta_-Catenin*|​pho|​pho@Nucleus map
  69. _beta_-Catenin*@Nucleus map map _beta_-Catenin*|​ace@Nucleus map
  70. _beta_-Catenin*|​pho|​pho@Nucleus map map degraded
  71. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  72. DVL*:​JUN|​pho|​pho@Nucleus map + BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  73. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*@Nucleus map
  74. BCL9@Nucleus map + _beta_-Catenin*|​ace@Nucleus map + PYGO*@Nucleus map map BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map
  75. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  76. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + SMAD1|​pho@Nucleus map map BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  77. _beta_-Catenin*@Nucleus map + NICD*@Nucleus map map s_s_wca3_s263
  78. _beta_-Catenin*@Nucleus map + NFKB1_p50*:​RELA@Nucleus map map s_s_wca3_s281
  79. Sonic hedgehog pathway@Extracellular space map map _beta_-Catenin*@Cytoplasm map
  80. _beta_-Catenin*@Nucleus map + APC|​S2034_pho@Nucleus map map s_s_wca3_s314
  81. _beta_-Catenin*@Nucleus map + APC@Nucleus map map s_s_wca3_s317
  82. _beta_-Catenin*@Cytoplasm map + Kindlin2*@Cytoplasm map map s_s_wca4_s5
  83. _beta_-Catenin*|​S522_pho@Cytoplasm map map _beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm map
  84. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​S522_pho@Cytoplasm map
  85. _beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm map map _beta_-Catenin*|​S522_pho|​S675_pho@Nucleus map
  86. _beta_-Catenin*|​S522_pho|​S675_pho@Nucleus map map Transcription@Nucleus map
  87. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​S552_pho@Cytoplasm map
  88. _beta_-Catenin*|​S552_pho@Cytoplasm map map _beta_-Catenin*|​S552_pho|​pho@Cytoplasm map
  89. r_beta_-Catenin*@Nucleus map map _beta_-Catenin*@Cytoplasm map
  90. E-Cadherin*@Cytoplasm map + p120*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + Cytoskeleton@Cytoplasm map map Cytoskeleton:​E-Cadherin*@Cytoplasm map
  91. _beta_-Catenin*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
  92. Cytoskeleton:​E-Cadherin*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map + p120*@Cytoplasm map + E-Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map
  93. Cytoskeleton:​E-Cadherin*@Cytoplasm map map Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map
  94. Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map map _beta_-Catenin*|​Y142_pho@Cytoplasm map + E-Cadherin*:​cytoskeleton@Cytoplasm map
  95. _beta_-Catenin*|​Y142_pho@Cytoplasm map map WNT canonical pathway nucleus@Cytoplasm map

As Catalyser:

  1. gMYC@Nucleus map map rMYC@Nucleus map

  2. gID2@Nucleus map map rID2@Nucleus map
  3. gAXIN2@Nucleus map map rAXIN2@Nucleus map
  4. gSNAI2@Nucleus map map rSNAI2@Nucleus map
  5. gCyclinD1*@Nucleus map map rCyclinD1*@Nucleus map
  6. gClaudin1*@Nucleus map map rClaudin1*@Nucleus map
  7. gClaudin2*@Nucleus map map rClaudin2*@Nucleus map
  8. gFibronectin*@Nucleus map map rFibronectin*@Nucleus map
  9. SRC@Cytoplasm map map SRC@Cytoplasm map
  10. gCyclinD*@Nucleus map map rCyclinD*@Nucleus map
  11. gAXIN1@Nucleus map map rAXIN1@Nucleus map
  12. gMMP9@Nucleus map map rMMP9@Nucleus map
  13. gGenes under control of _br_CBP-mediated transcription*@Nucleus map map rRNA@Nucleus map
  14. gTCF4@Nucleus map map rTCF4@Nucleus map
  15. gRAD6B*@Nucleus map map rRAD6B*@Nucleus map
  16. gBCL9@Nucleus map map rBCL9@Nucleus map
  17. gMIR372@Nucleus map map arMIR372@Nucleus map
  18. gMIR373@Nucleus map map arMIR373@Nucleus map
  19. gIRS2@Nucleus map map rIRS2@Nucleus map
  20. gCRIPTO-1*@Nucleus map map rCRIPTO-1*@Nucleus map
  21. gMYC@Nucleus map map rMYC@Nucleus map
  22. gGene under control of_br_ P300-mediated transcription*@Nucleus map map rRNA@Nucleus map

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