_beta_-Arrestin2*

Protein _beta_-Arrestin2* map

Identifiers
Arrestin beta 1
HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1
Arrestin beta 2
HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2
ARR2
arrestin 3″, BARR2, DKFZp686L0365

Maps_Modules
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:19853559
PMID:18497258
PMID:15618519
Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles.
MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN.
PMID:11226259 PMID:19565474

_beta_-Arrestin2*@Cytoplasm

References
s_shh1_re33:( Survival  map ) PMID:18497258
s_mpk1_re61( Survival  map ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259
s_wca1_re29( Survival  map ):
PMID:19705439 PMID:17426148
Beta-ARRESTIN binds to phosphorylated DVL
s_wca1_re45:( Survival  map ) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148
s_wnc1_re70:( Survival  map ) PMID:12958364


Modifications:
In compartment: Cytoplasm
  1. _beta_-Arrestin2*@Cytoplasm map

  2. _beta_-Arrestin2*@Cytoplasm map
  3. _beta_-Arrestin2*@Cytoplasm map
  4. _beta_-Arrestin2*@Cytoplasm map

In compartment: Primary Cilium

  1. _beta_-Arrestin2*@Primary Cilium map

Participates in complexes:
In compartment: Clathrin-coated vesicle

  1. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map

In compartment: Cytoplasm

  1. MEK*:​_beta_-Arrestin2*@Cytoplasm map

  2. DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  3. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map
  4. ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Cytoplasm map
  5. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map
  6. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  7. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  8. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  9. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  10. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  11. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  12. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  13. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map

In compartment: Early Endosomes

  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map

  2. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map

In compartment: Endosome

  1. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map

  2. AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  6. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  7. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  8. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  9. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  11. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  12. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  13. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  14. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  15. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  16. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  17. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

In compartment: Plasma Membrane

  1. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map

In compartment: Primary Cilium

  1. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map

In compartment: Vaceolae

  1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map

  2. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map

Participates in reactions:
As Reactant or Product:

  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map

  2. GPCR*|​pho:​GRK*@Plasma Membrane map + _beta_-Arrestin2*@Cytoplasm map map GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map
  3. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map + ERK*@Cytoplasm map + RAF1@Cytoplasm map + MEK*@Cytoplasm map map ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map
  4. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map map GPCR*:​GRK*@Early Endosomes map + ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + RAF1@Cytoplasm map
  5. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + ERK*|​pho|​pho@Cytoplasm map map ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Cytoplasm map
  6. SMO|​pho|​active@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map + KIF3A:​KIF3B@Cytoplasm map map KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map
  7. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map map _beta_-Arrestin2*@Primary Cilium map + SMO|​pho|​active@Primary Cilium map + KIF3A:​KIF3B@Primary Cilium map
  8. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map map KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map
  9. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + s_s_wca1_s1187 + G_beta_*:​G_gamma_*@Cytoplasm map
  10. DVL*|​pho|​S139_emp|​S142_emp@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map map DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map
  11. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  12. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  13. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  14. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  15. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  16. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  17. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  18. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  19. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map
  20. s_s_wca1_s1187 + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map map AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map
  21. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map Recycling @Cytoplasm map
  22. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map Degradation@Cytoplasm map
  23. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map map Recycling @Cytoplasm map
  24. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map map Degradation@Cytoplasm map
  25. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map DVL*|​pho|​S139_pho|​S142_pho|​pho@Endosome map + AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  26. RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  27. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  28. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map
  29. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  30. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  31. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  32. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map + WGEF*@Cytoplasm map + DAAM1@Cytoplasm map + RHOA@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  33. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map map Angiogenesis@Nucleus map
  34. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map + RHOA@Cytoplasm map
  35. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map + DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  36. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map WNT canonical pathway@Cytoplasm map
  37. _beta_-Arrestin2*@Cytoplasm map + DVL*|​pho|​pho|​pho@Cytoplasm map map DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  38. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  39. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  40. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map + DVL*|​pho|​emp|​emp|​ubi@Cytoplasm map
  41. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  42. SMURF1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  43. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map

As Catalyser:

  1. RSK*@Cytoplasm map map RSK*|​pho@Cytoplasm map

  2. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  3. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  5. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map
  6. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map
  7. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

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