_alpha_-Catenin*

Protein _alpha_-Catenin* map

Identifiers
catenin (cadherin-associated protein), alpha 1, 102kDa
HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1
catenin (cadherin-associated protein) alpha 2
HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2
catenin (cadherin-associated protein) alpha 3
HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3

Maps_Modules
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments

_alpha_-Catenin*@Cytoplasm

References
e_re1022( EMT  map ):
PMID:15609097
CTNNB1 (beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail.
Cadherin recruits CTNNA1 (alpha-catenin) to the complex.
CTNNA1 (alpha-catenin) binds to Actin filaments directly
CTNNA1 (alpha-catenin) and can also associate with other actin-binding proteins (MLLT4 or Formin)
CTNND1 (delta-catenin or p120) binds directly to Cadherin independently of the other catenins.
Catenins/Cadherin complex can further interact with a range of singaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics.
Stability of Cadherin/Catenins complex and thereby the integrity of adherens junctions is controlled by phosphorylation/dephosphorylation.
e_re1023( EMT  map ):
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments

_alpha_-Catenin*|​hm2@Cytoplasm

References
e_re1023( EMT  map ):
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments


Modifications:
In compartment: Cytoplasm
  1. _alpha_-Catenin*@Cytoplasm map

  2. _alpha_-Catenin*|​hm2@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. Actin cytoskeletal*:​_alpha_-Catenin*|​hm2@Cytoplasm map

  2. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map
  3. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. Catenin*@Cytoplasm map map _alpha_-Catenin*@Cytoplasm map

  2. _beta_-Catenin*@Cytoplasm map + Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map map Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map
  3. _alpha_-Catenin*@Cytoplasm map map _alpha_-Catenin*|​hm2@Cytoplasm map
  4. Actin cytoskeletal*@Cytoplasm map + _alpha_-Catenin*|​hm2@Cytoplasm map map Actin cytoskeletal*:​_alpha_-Catenin*|​hm2@Cytoplasm map
  5. Plakoglobin binding partners*@Cytoplasm map map _alpha_-Catenin*@Cytoplasm map
  6. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map map Adherens junctions@Cytoplasm map
  7. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytoplasm map + Cadherin*:​p120*@Cytoplasm map map Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map
  8. ECM or cell-cell contact@default map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map + p120*@Cytoplasm map + ITGA3@Cytoplasm map + Cytoskeleton@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map map Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact@Cytoplasm map
  9. E-Cadherin*@Cytoplasm map + p120*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + Cytoskeleton@Cytoplasm map map Cytoskeleton:​E-Cadherin*@Cytoplasm map
  10. Cytoskeleton:​E-Cadherin*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map + p120*@Cytoplasm map + E-Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map

As Catalyser:

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