14-3-3*:BAD

Complex 14-3-3*:BAD map


Complex composition:

  1. 14-3-3* map
  2. BAD map




14-3-3*:​BAD|​pho@Cytoplasm

Identifiers
NAME:14-3-3*:BAD

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds to 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)

Confidence
REF=1 FUNC=5

14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria

Identifiers
NAME:14-3-3*:BAD

Confidence
REF=0 FUNC=5

14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria

Identifiers
NAME:14-3-3*:BAD

References
s_akt1_re127:( Survival  map ) PMID:10949026

Confidence
REF=1 FUNC=5

14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria

Identifiers
NAME:14-3-3*:BAD

References
s_akt1_re125:( Survival  map ) PMID:10949026

Confidence
REF=1 FUNC=5

14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria

Identifiers
NAME:14-3-3*:BAD

References
s_akt1_re126:( Survival  map ) PMID:10949026

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. 14-3-3*:​BAD|​pho@Cytoplasm map

In compartment: Mitochondria

  1. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map

  2. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map
  3. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  4. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map

Participates in reactions:
As Reactant or Product:

  1. BAD|​pho@Mitochondria map + 14-3-3*@Cytoplasm map map 14-3-3*:​BAD|​pho@Cytoplasm map

  2. s_s_akt1_s528 + 14-3-3*@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map
  3. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  4. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map + BCL2-XL*@Mitochondria map
  5. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map map s_s_akt1_s561
  6. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map map Survival@Mitochondria map
  7. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map map s_s_wnc2_s86
  8. PI3K Akt MTOR pathway@Cytoplasm map map 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map

As Catalyser:

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