14-3-3*

Protein 14-3-3* map

Identifiers
14-3-3*
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB
stratifin
HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 GENECARDS:SFN REACTOME:48913 KEGG:2810 ATLASONC:GC_SFN WIKI:SFN
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MOMP_REGULATION  map
 Apoptosis  map  / TNF_RESPONSE  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
YWHAB is so-called 14-3-3 alpha/beta
PMID:9069260
synonym:14-3-3 theta
synonym:14-3-3 zeta
synonym:14-3-3 epsilon
for known differences between these different proteins, cf. notes for each individual reaction
PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040
PMID:18481918
PMID:19027299

14-3-3*@Cytoplasm

References
e_re1618( EMT  map ):
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds and postively influence on 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)

14-3-3*|​pho@Cytoplasm

References
a_re23( Apoptosis  map ):
PMID:15071501
in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX
in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ
putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ
a_re27:( Apoptosis  map ) reactionType:is.a

14-3-3*|​unk@Cytoplasm

References
a_re1310:( Apoptosis  map ) PMID:10411906

14-3-3*@Nucleus

References
s_shh2_re65:( Survival  map ) PMID:19996099

14-3-3*@Mitochondria

References
s_akt1_re124:( Survival  map ) PMID:10949026

14-3-3*@Nucleus

References
s_akt2_re8:( Survival  map ) PMID:11864996
s_akt2_re118:( Survival  map ) PMID:14664696
s_wnc2_re86:( Survival  map ) PMID:10611249


Modifications:
In compartment: Cytoplasm
  1. 14-3-3*@Cytoplasm map

  2. 14-3-3*|​pho@Cytoplasm map
  3. 14-3-3*|​unk@Cytoplasm map

In compartment: Lipid Raft

  1. 14-3-3*@Lipid Raft map

In compartment: Mitochondria

  1. 14-3-3*@Mitochondria map

In compartment: Nucleus

  1. 14-3-3*@Nucleus map

  2. 14-3-3*@Nucleus map
  3. 14-3-3*@Nucleus map

In compartment: default

  1. 14-3-3*@default map

Participates in complexes:
In compartment: Cytoplasm

  1. 14-3-3*:​BAD|​pho@Cytoplasm map

  2. 14-3-3*|​unk:​PRAS40*|​pho@Cytoplasm map
  3. 14-3-3*|​unk:​BimEL*|​S87_pho@Cytoplasm map
  4. 14-3-3*|​unk:​ASK1*|​unk|​S967_pho@Cytoplasm map
  5. 14-3-3*|​unk:​RPTOR|​S722_pho|​S792_pho@Cytoplasm map
  6. 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytoplasm map
  7. 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  8. 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map

In compartment: Endosome Membrane

  1. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

In compartment: Lipid Raft

  1. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map

In compartment: Membrane Lysosome

  1. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map

In compartment: Mitochondria

  1. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map

  2. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map
  3. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  4. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map

In compartment: Nucleus

  1. 14-3-3*:​FOXO3@Nucleus map

In compartment: default

  1. 14-3-3*:​CDC25B|​S230_pho|​S151_pho|​S323_pho@default map

  2. 14-3-3*:​CDC25C|​S191_pho|​S198_pho|​S214_pho@default map
  3. 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@default map

Participates in reactions:
As Reactant or Product:

  1. 14-3-3*|​unk@Cytoplasm map + p27KIP1*|​T198_pho|​T157_pho@Nucleus map map 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytoplasm map

  2. YWHAQ@Cytoplasm map map 14-3-3*@Cytoplasm map
  3. YWHAZ@Cytoplasm map map 14-3-3*@Cytoplasm map
  4. YWHAE@Cytoplasm map map 14-3-3*@Cytoplasm map
  5. YWHAB@Cytoplasm map map 14-3-3*@Cytoplasm map
  6. SFN@Cytoplasm map map 14-3-3*@Cytoplasm map
  7. YWHAG@Cytoplasm map map 14-3-3*@Cytoplasm map
  8. YWHAH@Cytoplasm map map 14-3-3*@Cytoplasm map
  9. ASK1*|​unk|​S967_pho@Cytoplasm map + 14-3-3*|​unk@Cytoplasm map map 14-3-3*|​unk:​ASK1*|​unk|​S967_pho@Cytoplasm map
  10. BAX@Cytoplasm map + 14-3-3*@Cytoplasm map map a_s118
  11. 14-3-3*@Cytoplasm map map cleaved~14-3-3*@Cytoplasm map
  12. 14-3-3*@Cytoplasm map map 14-3-3*|​pho@Cytoplasm map
  13. 14-3-3*|​pho@Cytoplasm map map 14-3-3*|​unk@Cytoplasm map
  14. 14-3-3*@Cytoplasm map map 14-3-3*|​unk@Cytoplasm map
  15. 14-3-3*|​unk@Cytoplasm map + FOXO*|​pho|​pho@Cytoplasm map map 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map
  16. 14-3-3*|​unk@Cytoplasm map + TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  17. 14-3-3*|​unk@Cytoplasm map + MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR@Cytoplasm map + 14-3-3*|​unk:​PRAS40*|​pho@Cytoplasm map
  18. 14-3-3*|​unk@Cytoplasm map + RPTOR|​S722_pho|​S792_pho@Cytoplasm map map 14-3-3*|​unk:​RPTOR|​S722_pho|​S792_pho@Cytoplasm map
  19. 14-3-3*|​unk@Cytoplasm map + BimEL*|​S87_pho@Cytoplasm map map 14-3-3*|​unk:​BimEL*|​S87_pho@Cytoplasm map
  20. BAD|​pho@Cytoplasm map + 14-3-3*|​unk@Cytoplasm map map a_s3150
  21. CDK1|​T161_pho:​CyclinB1*@default map + 14-3-3*@default map map 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@default map
  22. 14-3-3*@default map + CDC25B@default map map 14-3-3*:​CDC25B|​S230_pho|​S151_pho|​S323_pho@default map
  23. 14-3-3*@default map + CDC25C@default map map 14-3-3*:​CDC25C|​S191_pho|​S198_pho|​S214_pho@default map
  24. r14-3-3*@default map map 14-3-3*@default map
  25. BAD|​pho@Mitochondria map + 14-3-3*@Cytoplasm map map 14-3-3*:​BAD|​pho@Cytoplasm map
  26. 14-3-3*@Cytoplasm map map YWHAB@Cytoplasm map
  27. IGF family*:​IGF1R|​Y_pho|​hm2@Cytoplasm map map 14-3-3*@Cytoplasm map
  28. 14-3-3*@Cytoplasm map + FOXO3@Nucleus map map 14-3-3*:​FOXO3@Nucleus map
  29. FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map + 14-3-3*@Cytoplasm map map s_s_akt1_s479
  30. 14-3-3*@Cytoplasm map map 14-3-3*@Mitochondria map
  31. s_s_akt1_s528 + 14-3-3*@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map
  32. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  33. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map + BCL2-XL*@Mitochondria map
  34. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map map s_s_akt1_s561
  35. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map map s_s_akt1_s595
  36. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map map s_s_akt1_s642
  37. TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map + 14-3-3*@Cytoplasm map map 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  38. 14-3-3*@Cytoplasm map map 14-3-3*@Lipid Raft map
  39. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map map PROTOR*:​RICTOR|​T1135_pho@Cytoplasm map
  40. 14-3-3*@Cytoplasm map + RICTOR|​T1135_pho@Cytoplasm map map s_s_akt1_s829
  41. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  42. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map + 14-3-3*@Lipid Raft map map 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map
  43. p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map + 14-3-3*@Cytoplasm map map s_s_akt1_s462
  44. FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map + 14-3-3*@Nucleus map map s_s_akt2_s286
  45. s_s_akt2_s294 map 14-3-3*@Cytoplasm map + FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map
  46. FOXO4|​T28_pho|​S193_pho|​S258_pho@Cytoplasm map + 14-3-3*@Cytoplasm map map s_s_akt2_s328
  47. 14-3-3*@Cytoplasm map map 14-3-3*@Nucleus map
  48. s_s_akt2_s28 map 14-3-3*@Cytoplasm map + FOXO3|​pho|​pho|​pho@Cytoplasm map
  49. FOXO3|​pho|​pho|​pho@Nucleus map + 14-3-3*@Nucleus map map s_s_akt2_s25
  50. 14-3-3*@Nucleus map + GLI1|​S640_pho@Nucleus map map s_s_shh2_s104
  51. GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus map + 14-3-3*@Nucleus map map s_s_shh2_s110
  52. 14-3-3*@Nucleus map + GLI3-190*|​unk|​pho|​active@Nucleus map map s_s_shh2_s113
  53. RGS3|​S264_pho@Cytoplasm map + 14-3-3*@Cytoplasm map map s_s_wnc1_s275
  54. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map map Survival@Mitochondria map
  55. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map map s_s_wnc2_s86
  56. s_s_wnc2_s77 map BAD|​pho|​pho@Cytoplasm map + 14-3-3*@Cytoplasm map
  57. PI3K Akt MTOR pathway@Cytoplasm map map 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map
  58. NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map + 14-3-3*@Nucleus map map s_s_wnc2_s319

As Catalyser:

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