14-3-3*

Protein 14-3-3* map

Identifiers
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB
stratifin
HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 GENECARDS:SFN REACTOME:48913 KEGG:2810 ATLASONC:GC_SFN WIKI:SFN
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MOMP_REGULATION  map
 Apoptosis  map  / TNF_RESPONSE  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
synonym:14-3-3 theta
synonym:14-3-3 zeta
synonym:14-3-3 epsilon
for known differences between these different proteins, cf. notes for each individual reaction
PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040
PMID:18481918
PMID:19027299

14-3-3*@Cytoplasm

References
a_re1271:( Apoptosis  map ) reactionType:is.a
a_re21( Apoptosis  map ):
influenceDelete: re to 14-3-3*
considering that BAX cannot titrate 14-3-3
PMID:12426317
in Hela and NIH3T3, 14-3-3 binds to non phosphorylated BAX.
a_re22( Apoptosis  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
zVAD-fmk inhibits YWHAQ and YWHAE but not YWHAZ cleavage and dissociation from BAX
PMID:15071501
putative cleavage sites in YWHAB, YWHAG, YWHAE, YWHAQ, SFN
absent in YWHAQ
PMID:12657644
YWHAE cleaved by CASP3
a_re23( Apoptosis  map ):
in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX
in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ
putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ

14-3-3*|​pho@Cytoplasm

References
a_re23( Apoptosis  map ):
PMID:15071501
in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX
in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ
putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ
a_re27:( Apoptosis  map ) reactionType:is.a

14-3-3*|​unk@Cytoplasm

References
a_re1310:( Apoptosis  map ) PMID:10411906

14-3-3*@Nucleus

References
s_shh2_re65:( Survival  map ) PMID:19996099

14-3-3*@Cytoplasm

References
s_akt1_re200:( Survival  map ) PMID:20832730

14-3-3*@Mitochondria

References
s_akt1_re124:( Survival  map ) PMID:10949026

14-3-3*@Nucleus

References
s_akt2_re8:( Survival  map ) PMID:11864996
s_akt2_re118:( Survival  map ) PMID:14664696
s_wnc2_re86:( Survival  map ) PMID:10611249


Modifications:
In compartment: Cytoplasm
  1. 14-3-3*@Cytoplasm map

  2. 14-3-3*@Cytoplasm map
  3. 14-3-3*@Cytoplasm map
  4. 14-3-3*@Cytoplasm map
  5. 14-3-3*@Cytoplasm map
  6. 14-3-3*|​pho@Cytoplasm map
  7. 14-3-3*|​unk@Cytoplasm map

In compartment: Lipid Raft

  1. 14-3-3*@Lipid Raft map

In compartment: Mitochondria

  1. 14-3-3*@Mitochondria map

In compartment: Nucleus

  1. 14-3-3*@Nucleus map

  2. 14-3-3*@Nucleus map
  3. 14-3-3*@Nucleus map
  4. 14-3-3*@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. 14-3-3*:​BAX@Cytoplasm map

  2. 14-3-3*:​RGS3|​S264_pho@Cytoplasm map
  3. 14-3-3*:​RICTOR|​T1135_pho@Cytoplasm map
  4. 14-3-3*:​BAD|​pho|​pho@Cytoplasm map
  5. 14-3-3*|​unk:​BAD|​pho@Cytoplasm map
  6. 14-3-3*|​unk:​PRAS40*|​pho@Cytoplasm map
  7. 14-3-3*|​unk:​BimEL*|​S87_pho@Cytoplasm map
  8. 14-3-3*:​BAD|​pho|​pho|​pho@Cytoplasm map
  9. 14-3-3*:​FOXO3|​pho|​pho|​pho@Cytoplasm map
  10. 14-3-3*|​unk:​ASK1*|​unk|​S967_pho@Cytoplasm map
  11. 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Cytoplasm map
  12. 14-3-3*|​unk:​RPTOR|​S722_pho|​S792_pho@Cytoplasm map
  13. 14-3-3*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm map
  14. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Cytoplasm map
  15. 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytoplasm map
  16. 14-3-3*:​FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map
  17. 14-3-3*:​FOXO3|​T32_pho|​S253_pho|​S315_pho@Cytoplasm map
  18. 14-3-3*:​FOXO4|​T28_pho|​S193_pho|​S258_pho@Cytoplasm map
  19. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Cytoplasm map
  20. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Cytoplasm map
  21. 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  22. 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map
  23. 14-3-3*:​MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RICTOR|​T1135_pho@Cytoplasm map

In compartment: Endosome Membrane

  1. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

In compartment: Lipid Raft

  1. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map

In compartment: Membrane Lysosome

  1. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map

In compartment: Mitochondria

  1. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map

  2. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  3. 14-3-3*:​BAD|​S112_pho|​S136_pho:​BCL2-XL*@Mitochondria map
  4. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho:​BCL2-XL*@Mitochondria map

In compartment: Nucleus

  1. 14-3-3*:​GLI1|​S640_pho@Nucleus map

  2. 14-3-3*:​GLI3-190*|​unk|​pho@Nucleus map
  3. 14-3-3*:​FOXO3|​pho|​pho|​pho@Nucleus map
  4. 14-3-3*:​GLI2-185*|​pho|​unk|​S956_pho@Nucleus map
  5. 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map
  6. 14-3-3*:​FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map
  7. 14-3-3*:​FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map
  8. 14-3-3*:​CDC25B|​S230_pho|​S151_pho|​S323_pho@Nucleus map
  9. 14-3-3*:​CDC25C|​S191_pho|​S198_pho|​S214_pho@Nucleus map
  10. 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. 14-3-3*|​unk@Cytoplasm map + p27KIP1*|​T198_pho|​T157_pho@Nucleus map map 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytoplasm map

  2. YWHAQ@Cytoplasm map map 14-3-3*@Cytoplasm map
  3. YWHAZ@Cytoplasm map map 14-3-3*@Cytoplasm map
  4. YWHAE@Cytoplasm map map 14-3-3*@Cytoplasm map
  5. YWHAB@Cytoplasm map map 14-3-3*@Cytoplasm map
  6. SFN@Cytoplasm map map 14-3-3*@Cytoplasm map
  7. YWHAG@Cytoplasm map map 14-3-3*@Cytoplasm map
  8. YWHAH@Cytoplasm map map 14-3-3*@Cytoplasm map
  9. ASK1*|​unk|​S967_pho@Cytoplasm map + 14-3-3*|​unk@Cytoplasm map map 14-3-3*|​unk:​ASK1*|​unk|​S967_pho@Cytoplasm map
  10. BAX@Cytoplasm map + 14-3-3*@Cytoplasm map map 14-3-3*:​BAX@Cytoplasm map
  11. 14-3-3*@Cytoplasm map map cleaved~14-3-3*@Cytoplasm map
  12. 14-3-3*@Cytoplasm map map 14-3-3*|​pho@Cytoplasm map
  13. 14-3-3*|​pho@Cytoplasm map map 14-3-3*|​unk@Cytoplasm map
  14. 14-3-3*@Cytoplasm map map 14-3-3*|​unk@Cytoplasm map
  15. 14-3-3*|​unk@Cytoplasm map + FOXO*|​pho|​pho@Cytoplasm map map 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map
  16. 14-3-3*|​unk@Cytoplasm map + TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  17. 14-3-3*|​unk@Cytoplasm map + MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map map MLST8:​MTOR:​RPTOR@Cytoplasm map + 14-3-3*|​unk:​PRAS40*|​pho@Cytoplasm map
  18. 14-3-3*|​unk@Cytoplasm map + RPTOR|​S722_pho|​S792_pho@Cytoplasm map map 14-3-3*|​unk:​RPTOR|​S722_pho|​S792_pho@Cytoplasm map
  19. 14-3-3*|​unk@Cytoplasm map + BimEL*|​S87_pho@Cytoplasm map map 14-3-3*|​unk:​BimEL*|​S87_pho@Cytoplasm map
  20. BAD|​pho@Cytoplasm map + 14-3-3*|​unk@Cytoplasm map map 14-3-3*|​unk:​BAD|​pho@Cytoplasm map
  21. CDK1|​T161_pho:​CyclinB1*@Nucleus map + 14-3-3*@Nucleus map map 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@Nucleus map
  22. 14-3-3*@Nucleus map + CDC25B@Nucleus map map 14-3-3*:​CDC25B|​S230_pho|​S151_pho|​S323_pho@Nucleus map
  23. 14-3-3*@Nucleus map + CDC25C@Nucleus map map 14-3-3*:​CDC25C|​S191_pho|​S198_pho|​S214_pho@Nucleus map
  24. r14-3-3*@Nucleus map map 14-3-3*@Nucleus map
  25. FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map + 14-3-3*@Cytoplasm map map 14-3-3*:​FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map
  26. 14-3-3*:​FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map map 14-3-3*:​FOXO3|​T32_pho|​S253_pho|​S315_pho@Cytoplasm map
  27. 14-3-3*@Cytoplasm map map 14-3-3*@Mitochondria map
  28. BAD|​S112_pho|​S136_pho:​BCL2-XL*@Mitochondria map + 14-3-3*@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho:​BCL2-XL*@Mitochondria map
  29. 14-3-3*:​BAD|​S112_pho|​S136_pho:​BCL2-XL*@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho:​BCL2-XL*@Mitochondria map
  30. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho:​BCL2-XL*@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map + BCL2-XL*@Mitochondria map
  31. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Cytoplasm map
  32. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Cytoplasm map
  33. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map map 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Cytoplasm map
  34. TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map + 14-3-3*@Cytoplasm map map 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  35. 14-3-3*@Cytoplasm map map 14-3-3*@Lipid Raft map
  36. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map map 14-3-3*:​MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RICTOR|​T1135_pho@Cytoplasm map
  37. 14-3-3*@Cytoplasm map + RICTOR|​T1135_pho@Cytoplasm map map 14-3-3*:​RICTOR|​T1135_pho@Cytoplasm map
  38. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  39. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map + 14-3-3*@Lipid Raft map map 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map
  40. p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map + 14-3-3*@Cytoplasm map map 14-3-3*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm map
  41. FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map + 14-3-3*@Nucleus map map 14-3-3*:​FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map
  42. 14-3-3*:​FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map map 14-3-3*:​FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map
  43. 14-3-3*:​FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map map 14-3-3*@Cytoplasm map + FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map
  44. FOXO4|​T28_pho|​S193_pho|​S258_pho@Cytoplasm map + 14-3-3*@Cytoplasm map map 14-3-3*:​FOXO4|​T28_pho|​S193_pho|​S258_pho@Cytoplasm map
  45. 14-3-3*@Cytoplasm map map 14-3-3*@Nucleus map
  46. 14-3-3*:​FOXO3|​pho|​pho|​pho@Cytoplasm map map 14-3-3*@Cytoplasm map + FOXO3|​pho|​pho|​pho@Cytoplasm map
  47. FOXO3|​pho|​pho|​pho@Nucleus map + 14-3-3*@Nucleus map map 14-3-3*:​FOXO3|​pho|​pho|​pho@Nucleus map
  48. 14-3-3*:​FOXO3|​pho|​pho|​pho@Nucleus map map 14-3-3*:​FOXO3|​pho|​pho|​pho@Cytoplasm map
  49. 14-3-3*@Nucleus map + GLI1|​S640_pho@Nucleus map map 14-3-3*:​GLI1|​S640_pho@Nucleus map
  50. GLI2-185*|​pho|​unk|​S956_pho|​active@Nucleus map + 14-3-3*@Nucleus map map 14-3-3*:​GLI2-185*|​pho|​unk|​S956_pho@Nucleus map
  51. 14-3-3*@Nucleus map + GLI3-190*|​unk|​pho|​active@Nucleus map map 14-3-3*:​GLI3-190*|​unk|​pho@Nucleus map
  52. RGS3|​S264_pho@Cytoplasm map + 14-3-3*@Cytoplasm map map 14-3-3*:​RGS3|​S264_pho@Cytoplasm map
  53. 14-3-3*:​BAD|​pho|​pho|​pho@Cytoplasm map map 14-3-3*:​BAD|​pho|​pho@Cytoplasm map
  54. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map map Survival@Mitochondria map
  55. 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map map 14-3-3*:​BAD|​pho|​pho|​pho@Cytoplasm map
  56. 14-3-3*:​BAD|​pho|​pho@Cytoplasm map map BAD|​pho|​pho@Cytoplasm map + 14-3-3*@Cytoplasm map
  57. PI3K Akt MTOR pathway@Cytoplasm map map 14-3-3*:​BAD|​pho|​pho|​pho@Mitochondria map
  58. NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map + 14-3-3*@Nucleus map map 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map
  59. 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map map 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Cytoplasm map

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