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About ACSN 2.0

ACSN (https://acsn.curie.fr) is a web-based multi-scale resource of biological maps depicting molecular processes in cancer cell and tumor microenvironment. The Atlas represents interconnected cancer-related signalling and metabolic network maps. Molecular mechanisms are depicted on the maps at the level of biochemical interactions, forming a large seamless network of above 8000 reactions covering close to 3000 proteins and 800 genes and based on more than 4500 scientific publications. The Atlas is a "geographic-like" interactive "world map" of molecular interactions leading the hallmarks of cancer as described by Hanahan and Weinberg. Read more|Hide

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ACSN

Citing us

By using the Atlas (through the web interface, or the files you can download), you agree to cite it in any communication by refering to our main paper:
Kuperstein I, Bonnet E, Nguyen HA, Cohen D, Viara E, Grieco L, Fourquet S, Calzone L, Russo C, Kondratova M, Dutreix M, Barillot E, Zinovyev A. Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps. Oncogenesis. 2015 Jul 20;4:e160. doi: 10.1038/oncsis.2015.19. Pubmed ID: 26192618.



ACSN 2.0 in Numbers

Maps Species Proteins RNAs Antisense RNAs Genes Simple Molecules Small Molecules Reactions References
ACSN 2.0 Resource 9692 2997 740 130 808 665 775 8137 4532
Cancer Cell Map 7024 2329 531 120 593 492 596 5955 3121
Cell cycle and DNA repair Map 723 277 17 0 87 10 14 544 646
Cell Survival Map 1967 580 106 25 123 121 149 1341 869
Regulated Cell Death Map 2659 1008 260 93 215 338 407 2020 855
Telomere Maintenance Map 153 93 3 0 14 11 11 105 70
EMT-Senescence Map 1631 698 175 24 170 43 43 1581 691
Invasion and Motility Map 390 117 41 6 49 25 35 364 63
Tumor Microenvironment Map 2844 949 253 32 261 204 211 2182 1441
Angiogenesis Map 237 116 4 0 4 33 33 179 36
Adaptive Immunity Map 492 281 42 0 29 38 42 338 417
Innate Immunity Map 1466 583 152 20 165 104 108 1084 836
CAF Cell Map 682 300 86 13 87 41 41 581 380
Natural Killer Cell map 567 249 42 14 53 25 29 377 336
Macrophages and MDSC Cells map 588 217 95 4 95 42 44 457 214
Dendritic Cell map 491 226 44 1 43 38 40 346 333
Journals

The maps on ACSN 2.0 are based on literature extracted from specialized journals.

Venn

Due to its uniqueness, ACSN 2.0 has a large number of unique references.

Years

ACSN 2.0 References are quite recent, making it an up-to-date resource.



Tools related to ACSN 2.0

Navicell
Navicell
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Nvcom
Navicom
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Colaborations

ACSN is part of the Disease Maps Project, an open community effort to comprehensively represent disease mechanisms for various diseases.

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Publications

ACSN has been mentioned in many publications, find some here:

L Cristobal Monraz Gomez, Maria Kondratova, Jean-Marie Ravel, Emmanuel Barillot, Andrei Zinovyev, Inna Kuperstein; Application of Atlas of Cancer Signalling Network in preclinical studies, Briefings in Bioinformatics, bby031, https://doi.org/10.1093/bib/bby031.

Maria Kondratova, Nicolas Sompairac, Emmanuel Barillot, Andrei Zinovyev, Inna Kuperstein; Signalling maps in cancer research: construction and data analysis, Database, Volume 2018, 1 January 2018, bay036, https://doi.org/10.1093/database/bay036.

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ACSN 2.0 team

ACSN resource is developed at Institut Curie by the Computational Systems Biology of Cancer team Emmanuel Barillot
Eric Bonnet
Laurence Calzone
David Cohen
Mathurin Dorel
Simon Fourquet
Urszula Czerwinska
Laura Duciel
Luca Grieco
Maria Kondratova
Inna Kuperstein
Cristobal Monraz Gomez
Hien Anh Nguyen
Stuar Pook
Jean-Marie Ravel
Cristophe Russo
Nicolas Sompairac
Eric Viara
Andrei Zinovyev

Project Coordinator

Inna Kuperstein

ACSN former members

Eric Bonnet
David Cohen
Mathurin Dorel
Simon Fourquet
Luca Grieco
Alexander Klinge
Hien Anh Nguyen
Stuart Pook
Christophe Russo

ACSN 2.0 contributors

- Sebastian D Amigorena, Institut Curie, PSL Research University, Inserm, U932, F-75005, Paris, FranceDenis Thieffry, Ecole Normale Supérieure - Département de Biologie, IBENS - UMR ENS - CNRS 8197 - INSERM 1024, Paris France.
- Mathieu Boissan, Centre de recherche St-Antoine, Inserm, UMR938, Sorbonne Université, Paris, FranceGordon Tucker, Oncology Research and Development Unit, Institut de Recherches SERVIER, Croissy-sur-Seine, France.
- Guido Kroemer, UMR1138, Centre de Recherche des Cordeliers, Paris, France
- Jennifer Modamio, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Eschsur-Alzette, L-4362, LuxembourgPhilippe Chavrier, Institut Curie, Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France.
- Vassili Soumelis, Institut Curie, PSL Research University, Inserm, U932, F-75005, Paris, France
- Ines Thiele, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Eschsur-Alzette, L-4362, Luxembourg
- Ronan M. T. Fleming, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Faculty of Science, University of Leiden, Leiden, 2333, The Netherlands

Acknowledgments

INCa
inserm
H2020
Eraco
Agilent




Contact

Questions? Comments? Write us at acsn@curie.fr or to our social media