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y="785.5"/> </label> <bbox w="1800.0" h="770.0" x="3072.0" y="52.0"/> </glyph> <glyph class="compartment" id="c5_ca5"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="2424.5" y="3331.5"/> </label> <bbox w="4836.0" h="2469.0" x="40.0" y="910.0"/> </glyph> <glyph class="macromolecule" id="s1_sa1" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1"/> <bbox w="80.0" h="40.0" x="94.0" y="1547.0"/> <glyph class="state variable" id="_d9ec4cfb-2cfa-4e57-aae6-e67afd2f0ef0"> <state value="" 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DNA under t-loop conformation Telomeric DNA with G-quadruplexes Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:24993696, PMID:21209389, PMID:18680434 References_end</body> </html> </notes> <label text="Telomeric_DNA*"/> <bbox w="104.0" h="24.0" x="376.5" y="1948.75"/> </glyph> <glyph class="macromolecule multimer" id="s22_sa22" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1"/> <bbox w="86.0" h="46.0" x="410.0" y="1397.0"/> <glyph class="unit of information" 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<title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="1381.0" y="1227.0"/> <glyph class="unit of information" id="_162eaa1c-1bb3-4cc6-a1da-3bde54faad02"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1414.0" y="1222.0"/> </glyph> <glyph class="state variable" id="_61cf5651-c40d-4617-8127-0e7cbf8567f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1462.0" y="1245.0"/> </glyph> <glyph class="state variable" id="_97ea5154-ed4d-43d2-b74d-efb55865f95d"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="1373.5" y="1245.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s48_sa46" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="1381.0" y="1087.0"/> <glyph class="unit of information" id="_6f46126e-5b73-4628-84f8-a7f370e3f10d"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1414.0" y="1082.0"/> </glyph> <glyph class="state variable" id="_a2e6393c-51cf-4c7d-93ac-7040f469e6bd"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="1457.0" y="1105.0"/> </glyph> <glyph class="state variable" 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</head> <body>Identifiers_begin: TERF1 (TRF1-)interacting nuclear factor 2 HUGO:TINF2, HGNC:11824, ENTREZ:26277, UNIPROT:Q9BSI4, GENECARDS:TINF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of TINF2 PMID:10581025 References_end</body> </html> </notes> <label text="TINF2"/> <bbox w="80.0" h="40.0" x="1509.0" y="2045.0"/> <glyph class="state variable" id="_5897d685-bc6a-4135-acac-316b7a882d7e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="1499.0" y="2059.9683"/> </glyph> </glyph> <glyph class="source and sink" id="s85_sa86" compartmentRef="c5_ca5"> <label text="s85"/> <bbox w="30.0" h="30.0" x="1639.0" y="2055.0"/> </glyph> <glyph class="macromolecule" id="s86_sa87" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS, HGNC:11941, ENTREZ:8658, UNIPROT:O95271, GENECARDS:TNKS Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:9822378, PMID: 21181822, PMID:17825467 References_end</body> </html> </notes> <label text="TNKS"/> <bbox w="80.0" h="40.0" x="714.0" y="1430.0"/> <glyph class="state variable" id="_c8c6be1b-b353-4c46-b29b-85bdd60283aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="709.0" y="1431.8511"/> </glyph> </glyph> <glyph class="macromolecule" id="s88_sa88" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS, HGNC:11941, ENTREZ:8658, UNIPROT:O95271, GENECARDS:TNKS Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:9822378, PMID: 21181822, PMID:17825467 References_end</body> </html> </notes> <label text="TNKS"/> <bbox w="80.0" h="40.0" x="714.0" y="1570.0"/> <glyph class="state variable" id="_a469949d-787f-435c-989a-599f9e7666c8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="706.5" y="1571.8511"/> </glyph> </glyph> <glyph class="macromolecule" id="s89_sa89" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein-like 3 (nucleolar) HUGO:GNL3, HGNC:29931, ENTREZ:26354, UNIPROT:Q9BVP2, GENECARDS:GNL3 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: References_end</body> </html> </notes> <label text="GNL3"/> <bbox w="80.0" h="40.0" x="214.0" y="1704.0"/> </glyph> <glyph class="macromolecule" id="s90_sa90" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1, HGNC:1722, ENTREZ:983, UNIPROT:P06493, GENECARDS:CDK1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="361.0" y="1469.0"/> </glyph> <glyph class="macromolecule" id="s91_sa91" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: polo-like kinase 1 HUGO:PLK1, HGNC:9077, ENTREZ:5347, UNIPROT:P53350, GENECARDS:PLK1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:8127874 References_end</body> </html> </notes> <label text="PLK1"/> <bbox w="80.0" h="40.0" x="574.0" y="1340.0"/> </glyph> <glyph class="complex" id="s93_csa4" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Modules_begin: MODULE:SHELTERIN Modules_end</body> </html> </notes> <label text="TERF1/TINF2/TNKS"/> <bbox w="220.0" h="140.0" x="630.0" y="1020.0"/> <glyph class="macromolecule multimer" id="s56_sa53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="747.0" y="1037.0"/> <glyph class="unit of information" id="_59e4fd38-f16a-4da0-a696-8d73c6cc0df9"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="780.0" y="1032.0"/> </glyph> <glyph class="state variable" id="_59a89db6-4cbc-437d-8a42-9f15a470f283"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="828.0" y="1055.0"/> </glyph> <glyph class="state variable" id="_4d510415-4a40-4794-b5ae-bad3cda8bbd9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="742.0" y="1055.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s54_sa55"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: TERF1 (TRF1-)interacting nuclear factor 2 HUGO:TINF2, HGNC:11824, ENTREZ:26277, UNIPROT:Q9BSI4, GENECARDS:TINF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of TINF2 PMID:10581025 References_end</body> </html> </notes> <label text="TINF2"/> <bbox w="80.0" h="40.0" x="640.0" y="1040.0"/> <glyph class="state variable" id="_0dac240b-8817-43b3-8578-30e41db1b37d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="635.0" y="1054.9681"/> </glyph> </glyph> <glyph class="macromolecule" id="s92_sa92"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS, HGNC:11941, ENTREZ:8658, UNIPROT:O95271, GENECARDS:TNKS Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:9822378, PMID: 21181822, PMID:17825467 References_end</body> </html> </notes> <label text="TNKS"/> <bbox w="80.0" h="40.0" x="650.0" y="1090.0"/> <glyph class="state variable" id="_746a4ea3-c095-4f7a-8855-0895b87fb298"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="645.0" y="1091.8511"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s94_sa93" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 2, alpha 3 polypeptide HUGO:CSNK2A3, HGNC:2458, ENTREZ:1457, UNIPROT:P68400, GENECARDS:CSNK2A3 casein kinase 2, alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 casein kinase 2, alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 casein kinase 2, beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:13221602 References_end</body> </html> </notes> <label text="CK2*"/> <bbox w="80.0" h="40.0" x="294.0" y="1280.0"/> </glyph> <glyph class="macromolecule" id="s95_sa94" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Ataxia-telangectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315, GENECARDS:ATM Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="104.0" y="1470.0"/> </glyph> <glyph class="macromolecule" id="s96_sa95" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: siah E3 ubiquitin protein ligase 2 HUGO:SIAH2, HGNC:10858, Entrez:6478, UNIPROT:043255, GENECARDS:SIAH2 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: References_end</body> </html> </notes> <label text="SIAH2"/> <bbox w="80.0" h="40.0" x="1009.0" y="1650.0"/> </glyph> <glyph class="macromolecule" id="s97_sa96" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: ring finger protein, LIM domain interacting HUGO:RLIM, HGNC:13429, ENTREZ:51132, UNIPROT:Q9NVW2, GENECARDS:RLIM Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: References_end</body> </html> </notes> <label text="RLIM"/> <bbox w="80.0" h="40.0" x="1264.0" y="1180.0"/> </glyph> <glyph class="macromolecule" id="s98_sa97" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: F-box protein 4 HUGO:FBXO4, HGNC:13583, ENTREZ:26272, UNIPROT:Q9UKT5, GENECARDS:FBXO4 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:16275645 References_end</body> </html> </notes> <label text="FBXO4"/> <bbox w="80.0" h="40.0" x="1264.0" y="1110.0"/> </glyph> <glyph class="phenotype" id="s100_sa100" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Modules_begin: MODULE:SHELTERIN Modules_end</body> </html> </notes> <label text="DNA repair"/> <bbox w="90.0" h="35.0" x="1169.0" y="1980.5"/> </glyph> <glyph class="complex" id="s101_csa9" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:shelterin_complex_without_TERF1 ALT_NAME:POT1/RAP1A/Telomeric_DNA/TERF2/TINF2/TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:18680434 References_end</body> </html> </notes> <label text="shelterin_complex_without_TERF1"/> <bbox w="330.0" h="230.0" x="1479.0" y="1325.0"/> <glyph class="macromolecule" id="s102_sa102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tripeptidyl peptidase I HUGO:TPP1, HGNC:2073, ENTREZ:1200, UNIPROT:O14773, GENECARDS:TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504 Identification of TPP1 PMID:15231715 References_end</body> </html> </notes> <label text="TPP1"/> <bbox w="80.0" h="40.0" x="1489.0" y="1385.0"/> </glyph> <glyph class="macromolecule" id="s103_sa103"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: protection of telomere 1 HUGO:POT1, HGNC:17284, ENTREZ:25913, UNIPROT:Q9NUX5, GENECARDS:POT1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of POT1 PMID:11349150 References_end</body> </html> </notes> <label text="POT1"/> <bbox w="80.0" h="40.0" x="1489.0" y="1445.0"/> </glyph> <glyph class="macromolecule" id="s104_sa104"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: TERF1 (TRF1-)interacting nuclear factor 2 HUGO:TINF2, HGNC:11824, ENTREZ:26277, UNIPROT:Q9BSI4, GENECARDS:TINF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of TINF2 PMID:10581025 References_end</body> </html> </notes> <label text="TINF2"/> <bbox w="80.0" h="40.0" x="1609.0" y="1355.0"/> <glyph class="state variable" id="_63daa205-c5ed-4d20-b2c8-b270f6c22cd7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1604.0" y="1369.9681"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s105_sa105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Telomeric DNA Telomeric DNA under t-loop conformation Telomeric DNA with G-quadruplexes Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:24993696, PMID:21209389, PMID:18680434 References_end</body> </html> </notes> <label text="Telomeric_DNA*"/> <bbox w="115.0" h="22.5" x="1591.5" y="1463.75"/> </glyph> <glyph class="macromolecule multimer" id="s106_sa106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor 2 HUGO:TERF2, HGNC:11728, ENTREZ:7014, UNIPROT:Q15554, GENECARDS:TERF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF2 PMID:9326951 References_end</body> </html> </notes> <label text="TERF2"/> <bbox w="86.0" h="46.0" x="1716.0" y="1422.0"/> <glyph class="unit of information" id="_bef42f75-476b-4632-b59d-c4ccbd775f44"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1749.0" y="1417.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s107_sa107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RAP1A, member of RAS oncogene family HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="1719.0" y="1485.0"/> </glyph> </glyph> <glyph class="complex" id="s108_csa10" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:shelterin_complex_without_TINF2 ALT_NAME:POT1/RAP1A/Telomeric_DNA/TERF1/TERF2/TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:18680434 References_end</body> </html> </notes> <label text="shelterin_complew_without_TINF2"/> <bbox w="330.0" h="190.0" x="1602.0" y="1815.0"/> <glyph class="macromolecule" id="s109_sa109"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tripeptidyl peptidase I HUGO:TPP1, HGNC:2073, ENTREZ:1200, UNIPROT:O14773, GENECARDS:TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504 Identification of TPP1 PMID:15231715 References_end</body> </html> </notes> <label text="TPP1"/> <bbox w="80.0" h="40.0" x="1622.0" y="1835.0"/> </glyph> <glyph class="macromolecule" id="s110_sa110"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: protection of telomere 1 HUGO:POT1, HGNC:17284, ENTREZ:25913, UNIPROT:Q9NUX5, GENECARDS:POT1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of POT1 PMID:11349150 References_end</body> </html> </notes> <label text="POT1"/> <bbox w="80.0" h="40.0" x="1622.0" y="1895.0"/> </glyph> <glyph class="macromolecule multimer" id="s111_sa111"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="1729.0" y="1842.0"/> <glyph class="unit of information" id="_c90beb22-09fd-4f06-99b5-571ed63fdf6a"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1762.0" y="1837.0"/> </glyph> <glyph class="state variable" id="_20e6b637-447b-44f1-93b4-8512d841078b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1810.0" y="1860.0"/> </glyph> <glyph class="state variable" id="_2d786013-7c14-4a6b-a340-2e2dc8f6ccf8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1724.0" y="1860.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s112_sa112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Telomeric DNA Telomeric DNA under t-loop conformation Telomeric DNA with G-quadruplexes Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:24993696, PMID:21209389, PMID:18680434 References_end</body> </html> </notes> <label text="Telomeric_DNA*"/> <bbox w="115.0" h="22.5" x="1714.5" y="1913.75"/> </glyph> <glyph class="macromolecule multimer" id="s113_sa113"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor 2 HUGO:TERF2, HGNC:11728, ENTREZ:7014, UNIPROT:Q15554, GENECARDS:TERF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF2 PMID:9326951 References_end</body> </html> </notes> <label text="TERF2"/> <bbox w="86.0" h="46.0" x="1839.0" y="1882.0"/> <glyph class="unit of information" id="_d2458cc1-c7c3-493c-9cca-2341434b1b7b"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1872.0" y="1877.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s114_sa114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RAP1A, member of RAS oncogene family HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="1842.0" y="1935.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s115_sa21" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1"/> <bbox w="86.0" h="46.0" x="271.0" y="1397.0"/> <glyph class="unit of information" id="_2ffd161e-eba1-4a5d-9078-21a0edc0b351"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="304.0" y="1392.0"/> </glyph> <glyph class="state variable" id="_2e16bf7c-c4fe-427a-af79-807631f89cd9"> <state value="P" variable="T344"/> <bbox w="35.0" h="10.0" x="296.53424" y="1392.0"/> </glyph> <glyph class="state variable" id="_c53a8bb4-6c0b-455e-8dff-78dbcbcbbfa4"> <state value="" variable="S435"/> <bbox 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<bbox w="86.0" h="46.0" x="501.0" y="1277.0"/> <glyph class="unit of information" id="_3032cc8c-e533-467f-add2-21f3d59c0fdc"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="534.0" y="1272.0"/> </glyph> <glyph class="state variable" id="_15a207e1-93d4-44b9-9c83-57cd7144a637"> <state value="P" variable="T344"/> <bbox w="35.0" h="10.0" x="526.53424" y="1272.0"/> </glyph> <glyph class="state variable" id="_a796ad0a-294d-4f70-b33c-80a617332090"> <state value="" variable="S435"/> <bbox w="30.0" h="10.0" x="572.0" y="1295.0"/> </glyph> <glyph class="state variable" id="_5243b54d-5936-46dc-a290-33cb72cfba79"> <state value="P" variable="T122"/> <bbox w="35.0" h="10.0" x="527.2573" y="1318.0"/> </glyph> <glyph class="state variable" id="_0472a6bc-bbd5-48ad-bf79-d84911a3a195"> <state value="" variable="S367"/> <bbox w="30.0" h="10.0" x="486.0" y="1294.9634"/> </glyph> </glyph> <glyph class="macromolecule" id="s124_sa9" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="394.0" y="1690.0"/> </glyph> <glyph class="macromolecule" id="s132_sa124" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>DNA cross-link repair 1B HUGO:DCLRE1B Modules_begin: MODULE:REPLICATION Modules_end PMID:</body> </html> </notes> <label text="SNM1B*"/> <bbox w="80.0" h="40.0" x="403.0" y="2515.0"/> </glyph> <glyph class="macromolecule" id="s134_sa127" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>exonuclease 1 Identifiers_begin: HUGO:EXO1 Identifiers_end Modules_begin: MODULE:REPLICATION Modules_end References_begin: References_end</body> </html> </notes> <label text="EXO1"/> <bbox w="80.0" h="40.0" x="270.0" 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<label text="SHQ1"/> <bbox w="80.0" h="40.0" x="3350.0" y="2496.0"/> </glyph> <glyph class="macromolecule" id="s183_sa174"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: dyskeratosis congenita 1, dyskerin HUGO:DKC1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1"/> <bbox w="80.0" h="40.0" x="3350.0" y="2546.0"/> </glyph> </glyph> <glyph class="complex" id="s278_csa17" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:NHP2/NOP10 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end Refenreces_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NHP2/NOP10"/> <bbox w="100.0" h="120.0" x="3498.0" 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<body>Identifiers_begin: WD repeat containing, antisens to TP53 HUGO:WRAP53 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="WRAP53"/> <bbox w="80.0" h="40.0" x="2666.0" y="2382.0"/> </glyph> </glyph> <glyph class="complex" id="s289_csa30" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>NAME:DKC1/GAR1/NHP2/NOP10/TERC/WRAP53 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1/GAR1/NHP2/NOP10/TERC/WRAP53"/> <bbox w="305.0" h="130.0" x="2651.0" y="2020.0"/> <glyph class="macromolecule" id="s262_sa240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NHP2 ribonucleoprotein HUGO:NHP2 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NHP2"/> <bbox w="80.0" h="40.0" x="2671.0" y="2040.0"/> </glyph> <glyph class="macromolecule" id="s263_sa241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: dyskeratosis congenita 1, dyskerin HUGO:DKC1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1"/> <bbox w="80.0" h="40.0" x="2761.0" y="2040.0"/> </glyph> <glyph class="macromolecule" id="s264_sa242"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NOP10 ribonucleoprotein HUGO:NOP10 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NOP10"/> <bbox w="80.0" h="40.0" x="2671.0" y="2090.0"/> </glyph> <glyph class="macromolecule" id="s265_sa243"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: GAR1 homolog, ribonucleoprotein HUGO:GAR1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="GAR1"/> <bbox w="80.0" h="40.0" x="2761.0" y="2090.0"/> </glyph> <glyph class="nucleic acid feature" id="s266_sa244"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase RNA component HUGO:TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERC"/> 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>NAME:telomerase ALT_NAME:DKC1/GAR1/NHP2/NOP10/TERC/WRAP53 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="telomerase"/> <bbox w="425.0" h="200.0" x="2751.0" y="1611.0"/> <glyph class="macromolecule" id="s402_sa247"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="2976.0" y="1641.0"/> <glyph class="state variable" id="_878273e0-f017-45d9-a2e5-8124079b3e85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3008.5012" y="1676.0"/> </glyph> <glyph class="state variable" 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</notes> <label text="TERC"/> <bbox w="90.0" h="25.0" x="3061.0" y="1658.5"/> <glyph class="state variable" id="_b21cafcb-41d0-4d54-95be-ad3de97a0306"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3096.5" y="1653.5"/> </glyph> <glyph class="unit of information" id="_7fdd2891-9943-4178-9809-842b3e4d87ac"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3096.0" y="1653.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s409_sa287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>prostaglandin E synthase 3 (cytosolic) HUGO:PTGES3 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10197982 References_end</body> </html> </notes> <label text="PTGES3"/> <bbox w="80.0" h="40.0" x="2871.0" y="1641.0"/> </glyph> <glyph class="macromolecule multimer" id="s410_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:21945180 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="86.0" h="46.0" x="2768.0" y="1708.0"/> <glyph class="unit of information" id="_50a103f3-aced-4eb3-ad73-9d66184c5806"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="2801.0" y="1703.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s305_csa33" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:RNA_polymerase_II ALT_NAME:PLR2A/PLR2B/POLR2C/POLR2D/POLR2E/POLR2F/POLR2G/POLR2H/POLR2I/POLR2J/POLR2J2/POLR2J3/POLR2K/POLR2L Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:9201987, PMID:10567706 References_end</body> </html> </notes> <label text="RNA_polymerase_II"/> <bbox w="380.0" h="240.0" x="4441.0" y="2477.0"/> <glyph class="macromolecule" id="s291_sa254"> <label text="POLR2A"/> <bbox w="80.0" h="40.0" x="4461.0" y="2497.0"/> </glyph> <glyph class="macromolecule" id="s292_sa255"> <label text="POLR2B"/> <bbox w="80.0" h="40.0" x="4551.0" y="2498.0"/> </glyph> <glyph class="macromolecule" id="s293_sa256"> <label text="POLR2C"/> <bbox w="80.0" h="40.0" x="4641.0" y="2497.0"/> </glyph> <glyph class="macromolecule" id="s294_sa257"> <label text="POLR2D"/> <bbox w="80.0" h="40.0" x="4731.0" y="2497.0"/> </glyph> <glyph class="macromolecule" id="s295_sa258"> <label text="POLR2E"/> <bbox w="80.0" h="40.0" x="4461.0" y="2547.0"/> </glyph> <glyph class="macromolecule" id="s296_sa259"> <label text="POLR2F"/> <bbox w="80.0" h="40.0" x="4551.0" y="2547.0"/> </glyph> <glyph class="macromolecule" id="s297_sa260"> <label text="POLR2G"/> <bbox w="80.0" h="40.0" x="4641.0" y="2547.0"/> 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: GAR1 homolog, ribonucleoprotein HUGO:GAR1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="GAR1"/> <bbox w="80.0" h="40.0" x="3228.0" y="2240.0"/> </glyph> <glyph class="nucleic acid feature" id="s315_sa268" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="TERT"/> <bbox w="90.0" h="25.0" x="3187.0" y="571.5"/> <glyph class="unit of information" id="_5974cbc1-b960-4740-b1a5-afb8f7a3ab64"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3222.0" y="566.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s319_sa271" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 v-akt murine thymoma viral oncogene homolog 3 HUGO:AKT3 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:25924008 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="3862.0" y="682.0"/> </glyph> <glyph class="macromolecule multimer" id="s321_sa273" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:21945180 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="86.0" h="46.0" x="3399.0" y="499.0"/> <glyph class="unit of information" id="_6ae311c9-6c0a-4ec6-a66c-2a8d759362e2"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="3432.0" y="494.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s322_sa274" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>prostaglandin E synthase 3 (cytosolic) HUGO:PTGES3 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10197982 References_end</body> </html> </notes> <label text="PTGES3"/> <clone/> <bbox w="80.0" h="40.0" x="3502.0" y="462.0"/> </glyph> <glyph class="macromolecule" id="s322_sa302" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>prostaglandin E synthase 3 (cytosolic) HUGO:PTGES3 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10197982 References_end</body> </html> </notes> <label text="PTGES3"/> <clone/> <bbox w="80.0" h="40.0" x="4062.0" y="432.0"/> </glyph> <glyph class="macromolecule" id="s343_sa290" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="3382.0" y="672.0"/> <glyph class="state variable" id="_cdea70fa-a64a-49c9-8763-3279962c1c6f"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="3409.5012" y="707.0"/> </glyph> <glyph class="state variable" id="_38fb827b-46da-4479-b4cd-e4c910ab35d8"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="3404.6292" y="667.0"/> </glyph> <glyph class="state variable" 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<body>Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A heat shock 70kDa protein 1B HUGO:HSP1B heat shock 70kDa protein 1-like HUGO:HSPA1L Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453 References_end</body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="3612.0" y="522.0"/> </glyph> <glyph class="macromolecule" id="s347_sa297" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: STIP1 homology and U-box containing protin 1, E3 ubiquitin protein ligase HUGO:STUB1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453, PMID:25487024 References_end</body> </html> </notes> <label text="STUB1"/> <clone/> <bbox w="80.0" h="40.0" x="3792.0" y="522.0"/> </glyph> <glyph class="macromolecule" id="s347_sa305" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: STIP1 homology and U-box containing protin 1, E3 ubiquitin protein ligase HUGO:STUB1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453, PMID:25487024 References_end</body> </html> </notes> <label text="STUB1"/> <clone/> <bbox w="80.0" h="40.0" x="4346.0" y="142.0"/> </glyph> <glyph class="source and sink" id="s359_sa310" compartmentRef="c4_ca4"> <label text="s359"/> <bbox w="30.0" h="30.0" x="4794.0" y="226.0"/> </glyph> <glyph class="macromolecule" id="s366_sa313" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: ABL proto-oncongene 1, non receptor tyrosine-kinase HUGO:ABL1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10837221 References_end</body> </html> </notes> <label text="ABL1"/> <bbox w="80.0" h="40.0" x="3212.0" y="482.0"/> </glyph> <glyph class="complex" id="s387_csa28" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Idenitifiers_begin: NAME:DKC1/GAR1/NHP2/NOP10/TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1/GAR1/NHP2/NOP10/TERC"/> <bbox w="320.0" h="140.0" x="3606.0" y="1976.0"/> <glyph class="macromolecule" id="s388_sa228"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NOP10 ribonucleoprotein HUGO:NOP10 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NOP10"/> <bbox w="80.0" h="40.0" x="3636.0" y="2046.0"/> </glyph> <glyph class="macromolecule" id="s389_sa229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NHP2 ribonucleoprotein HUGO:NHP2 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NHP2"/> <bbox w="80.0" h="40.0" x="3636.0" y="1996.0"/> </glyph> <glyph class="macromolecule" id="s390_sa230"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: dyskeratosis congenita 1, dyskerin HUGO:DKC1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1"/> <bbox w="80.0" h="40.0" x="3726.0" y="1996.0"/> </glyph> <glyph class="nucleic acid feature" id="s391_sa231"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase RNA component HUGO:TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERC"/> <bbox w="90.0" h="25.0" x="3821.0" y="2023.5"/> <glyph class="state variable" id="_919e7812-6804-4407-b5ed-d5f2ac719b56"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3856.5" y="2018.5"/> </glyph> <glyph class="unit of information" id="_a4cf9b37-af5a-4e63-a0ac-1950ca6bc66b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3856.0" y="2018.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s392_sa232"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: GAR1 homolog, ribonucleoprotein HUGO:GAR1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="GAR1"/> <bbox w="80.0" h="40.0" x="3726.0" y="2046.0"/> </glyph> </glyph> <glyph class="complex" id="s411_csa27" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKC1/GAR1/NHP2/NOP10/TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1/GAR1/NHP2/NOP10/TERC"/> <bbox w="330.0" h="130.0" x="2874.0" y="2308.0"/> <glyph class="macromolecule" id="s412_sa223"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NOP10 ribonucleoprotein HUGO:NOP10 Identifiers_end 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: GAR1 homolog, ribonucleoprotein HUGO:GAR1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="GAR1"/> <bbox w="80.0" h="40.0" x="2994.0" y="2378.0"/> </glyph> </glyph> <glyph class="source and sink" id="s431_sa336" compartmentRef="c5_ca5"> <label text="s431"/> <bbox w="30.0" h="30.0" x="2285.0" y="1182.0"/> </glyph> <glyph class="macromolecule" id="s432_sa337" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: makorin ring finger protein 1 HUGO:MKRN1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:15805468 References_end</body> </html> </notes> <label text="MKRN1"/> <bbox w="80.0" h="40.0" x="2331.889" y="1489.0"/> </glyph> <glyph class="macromolecule" id="s433_sa370" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: v-myc avian myelocytomatosis viral oncogene homolog HUGO:MYC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4028.5" y="1635.5"/> </glyph> <glyph class="macromolecule" id="s434_sa339" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 HUGO:NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 HUGO:NFATC3 nuclear factor of activated T-cells, 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text="ETV1"/> <bbox w="80.0" h="40.0" x="4557.0" y="1648.0"/> </glyph> <glyph class="macromolecule" id="s441_sa371" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: MAX dimerization protein 1 HUGO:MXD1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="MXD1"/> <bbox w="80.0" h="40.0" x="4028.5" y="1371.5"/> </glyph> <glyph class="macromolecule" id="s442_sa345" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tumor protein p53 HUGO:TP53 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="4384.0" y="1377.0"/> </glyph> <glyph class="macromolecule" id="s443_sa346" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Wilms tumor 1 HUGO:WT1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="WT1"/> <bbox w="80.0" h="40.0" x="4468.0" y="1379.0"/> </glyph> <glyph class="nucleic acid feature" id="s448_sa167" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="TERT"/> <bbox w="90.0" h="25.0" x="4623.0" y="1508.5"/> <glyph class="unit of information" id="_b0ee1694-8b37-46bc-8fa0-0ef8c6bc8cee"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4658.0" y="1503.5"/> </glyph> </glyph> <glyph class="complex" id="s454_csa38" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:HSP70*/HSP90*/PTGES3/STUB1/TERT Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453 References_end</body> </html> </notes> <label text="HSP70*/HSP90*/PTGES3/STUB1/TERT"/> <bbox w="265.0" h="175.0" x="3699.5" y="294.5"/> <glyph class="macromolecule" id="s349_sa293"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="3709.5" y="308.5"/> <glyph class="state variable" id="_f953c2b0-232c-48a2-b124-352135a4fdfd"> <state value="" variable=""/> 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:21945180 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="86.0" h="46.0" x="3806.5" y="311.5"/> <glyph class="unit of information" id="_6611ab80-e48c-43d3-9ee6-8692feb6e705"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="3839.5" y="306.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s353_sa298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: STIP1 homology and U-box containing protin 1, E3 ubiquitin protein ligase HUGO:STUB1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453, PMID:25487024 References_end</body> </html> </notes> <label text="STUB1"/> <bbox w="80.0" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>oligonucleotide/oligosaccharide-binding fold containing 1 HUGO:OBFC1 MODULE:REPLICATION</body> </html> </notes> <label text="STN1*"/> <bbox w="80.0" h="40.0" x="257.0" y="2341.0"/> </glyph> <glyph class="macromolecule" id="s501_sa389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>TEN1 CST complex subunit HUGO:TEN1 MODULE:REPLICATION PMID:</body> </html> </notes> <label text="TEN1"/> <bbox w="80.0" h="40.0" x="256.0" y="2392.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s503_sa390" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome RecQ like helicase HUGO:WRN Identifiers_end Modules_begin: MODULE:REPLICATION Modules_end References_begin: 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y="2075.0"/> </glyph> <glyph class="complex" id="s506_csa58" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:shelterin complex with uncoiled DNA ALT_NAME:POT1/RAP1A/TERF1/TERF2/TINF2/TPP1/Uncoiled_telomeric_DNA Identifiers_end Modules_begin: MODULE:REPLICATION Modules_end</body> </html> </notes> <label text="shelterin_complex_with_uncoiled_DNA"/> <bbox w="368.0" h="226.0" x="730.0" y="2206.0"/> <glyph class="macromolecule" id="s513_sa393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tripeptidyl peptidase I HUGO:TPP1, HGNC:2073, ENTREZ:1200, UNIPROT:O14773, GENECARDS:TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504 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PMID;16166375, PMID:19965504 Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="1002.17645" y="2358.7058"/> </glyph> <glyph class="nucleic acid feature" id="s514_sa400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>uncoiled telomeric DNA MODULE:REPLICATION PMID:</body> </html> </notes> <label text="Uncoiled_telomeric_DNA*"/> <bbox w="156.0" h="28.0" x="837.0" y="2343.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s515_sa401" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: cortisol CHEBI:17650 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="cortisol"/> <bbox w="70.0" h="25.0" x="4568.0" y="1347.5"/> </glyph> <glyph class="nucleic acid feature" id="s516_sa407" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>nascent TERC RNA Modules_begin: MODULE:TELOMERASE Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: telomerase RNA component HUGO:TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERC"/> <bbox w="90.0" h="25.0" x="4282.25" y="2681.0"/> <glyph class="state variable" id="_b1d59b08-defb-46c7-9adf-2bfb89460657"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4315.25" y="2676.0"/> </glyph> <glyph class="unit of information" id="_ef5b091a-020f-4ab6-bc40-5c1178b0b5f8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4317.25" y="2676.0"/> </glyph> </glyph> <glyph class="complex" id="s526_csa60" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:β-catenin*/KLF4 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="β-catenin*/KLF4"/> <bbox w="100.0" h="120.0" x="4730.0" y="1511.0"/> <glyph class="macromolecule" id="s523_sa408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>catenin (cadherin-associated protein), beta 1, 88kDa HUGO:CTNNB1 MODULE:TELOMERASE PMID:</body> </html> </notes> <label text="β-catenin*"/> <bbox w="80.0" h="40.0" x="4741.0" y="1523.0"/> </glyph> <glyph class="macromolecule" id="s524_sa409"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Kruppel-like factor 4 (gut) HUGO:KLF4 MODULE:TELOMERASE PMID:</body> </html> </notes> <label text="KLF4"/> <bbox w="80.0" h="40.0" x="4741.0" y="1569.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s179_sa171" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like AAA ATPase 2 HUGO:RUVBL2 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="Reptin*"/> <bbox w="92.0" h="52.0" x="3161.0" y="1924.0"/> <glyph class="unit of information" id="_a03b1ccc-32b2-41ad-a91f-cec56b10274d"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="3197.0" y="1919.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s180_sa172" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like AAA ATPase 1 HUGO:RUVBL1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="Pontin*"/> <bbox w="92.0" h="52.0" x="3161.0" y="1864.0"/> <glyph class="unit of information" id="_27ed1b39-eb65-45ee-b292-dca881a9d42e"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="3197.0" y="1859.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s538_sa414" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: PIH1 domain containing 1 HUGO:PIH1D1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="PH1D1"/> <bbox w="80.0" h="40.0" x="3329.2942" y="2703.0588"/> </glyph> <glyph class="complex" id="s554_csa2" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:shelterin_complex ALT_NAME:POT1/RAP1A/Telomeric_DNA/TERF1/TERF2/TINF2/TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:18680434, PMID;16166375, PMID:19965504, PMID:18828880 References_end</body> </html> </notes> <label text="shelterin_complex"/> <bbox w="330.0" h="230.0" x="892.0" y="1225.0"/> <glyph class="macromolecule multimer" id="s38_sa37"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="999.0" y="1292.0"/> <glyph class="unit of information" id="_ef261464-6e36-43c3-adc8-b2912b17105e"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1032.0" y="1287.0"/> </glyph> <glyph class="state variable" id="_72b2a552-4220-4633-b97f-a006b9054b55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1080.0" y="1310.0"/> </glyph> <glyph class="state variable" id="_e68aa89e-0b1a-4f89-8b47-6caebb1e0b17"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="991.5" y="1310.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s559_sa36"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Telomeric DNA Telomeric DNA under t-loop conformation Telomeric DNA with G-quadruplexes Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:24993696, PMID:21209389, PMID:18680434 References_end</body> </html> </notes> <label text="Telomeric_DNA*"/> <bbox w="115.0" h="22.5" x="989.5" y="1344.75"/> </glyph> <glyph class="macromolecule" id="s558_sa35"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: protection of telomere 1 HUGO:POT1, HGNC:17284, ENTREZ:25913, UNIPROT:Q9NUX5, GENECARDS:POT1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of POT1 PMID:11349150 References_end</body> </html> </notes> <label text="POT1"/> <bbox w="80.0" h="40.0" x="902.0" y="1335.0"/> </glyph> <glyph class="macromolecule" id="s557_sa34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tripeptidyl peptidase I HUGO:TPP1, HGNC:2073, ENTREZ:1200, UNIPROT:O14773, GENECARDS:TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504 Identification of TPP1 PMID:15231715 References_end</body> </html> </notes> <label text="TPP1"/> <bbox w="80.0" h="40.0" x="902.0" y="1285.0"/> </glyph> <glyph class="macromolecule" id="s565_sa33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: TERF1 (TRF1-)interacting nuclear factor 2 HUGO:TINF2, HGNC:11824, ENTREZ:26277, UNIPROT:Q9BSI4, GENECARDS:TINF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of TINF2 PMID:10581025 References_end</body> </html> </notes> <label text="TINF2"/> <bbox w="80.0" h="40.0" x="1022.0" y="1245.0"/> <glyph class="state variable" id="_8f78cb11-1171-44da-8c70-79c28d06dc9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1017.0" y="1259.9681"/> </glyph> </glyph> <glyph class="macromolecule" id="s556_sa32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RAP1A, member of RAS oncogene family HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="1112.0" y="1375.0"/> </glyph> <glyph class="macromolecule multimer" id="s555_sa31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor 2 HUGO:TERF2, HGNC:11728, ENTREZ:7014, UNIPROT:Q15554, GENECARDS:TERF2 Identifiers_end 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<notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NHP2 ribonucleoprotein HUGO:NHP2 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NHP2"/> <bbox w="80.0" h="40.0" x="3796.5" y="2326.5"/> </glyph> <glyph class="macromolecule" id="s574_sa211"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: dyskeratosis congenita 1, dyskerin HUGO:DKC1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1"/> <bbox w="80.0" h="40.0" x="3886.5" y="2326.5"/> </glyph> <glyph class="macromolecule" id="s575_sa212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NOP10 ribonucleoprotein HUGO:NOP10 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NOP10"/> <bbox w="80.0" h="40.0" x="3796.5" y="2376.5"/> </glyph> <glyph class="macromolecule" id="s576_sa213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: nuclear assembly factor 1 ribonucleoprotein HUGO:NAF1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NAF1"/> <bbox w="80.0" h="40.0" x="3886.5" y="2376.5"/> </glyph> <glyph class="nucleic acid feature" id="s234_sa216"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase RNA component HUGO:TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERC"/> <bbox w="90.0" h="25.0" x="3984.0" y="2361.5"/> <glyph class="state variable" id="_0f3f3a28-5290-4473-a524-fbc92702ae7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4019.5" y="2356.5"/> </glyph> <glyph class="unit of information" id="_d39a9f70-7df5-4141-bde7-d60e39118694"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4019.0" y="2356.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s577_csa35" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:HSP90*/PTGES3/TERT Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10197982 References_end</body> </html> 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References_end</body> </html> </notes> <label text="PTGES3"/> <bbox w="80.0" h="40.0" x="4031.0" y="647.0"/> </glyph> </glyph> <glyph class="complex" id="s580_csa49" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:HSP70*/HSP90*/STUB1/TERT Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453 References_end</body> </html> </notes> <label text="HSP70*/HSP90*/STUB1/TERT"/> <bbox w="265.0" h="175.0" x="4465.75" y="154.0"/> <glyph class="macromolecule" id="s467_sa352"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="4475.75" y="174.0"/> <glyph class="state variable" id="_493802fa-d7bc-42fd-925f-3a9e78cc5ed1"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4503.251" y="209.0"/> </glyph> <glyph class="state variable" id="_fe3da3f6-5c23-4edd-89dc-763a89191be5"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="4498.379" y="169.0"/> </glyph> <glyph class="state variable" id="_c0c83341-1aa0-473b-8e72-2b664d885336"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4470.75" y="188.96815"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s581_sa353"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:21945180 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="86.0" h="46.0" x="4572.75" y="171.0"/> <glyph class="unit of information" id="_ef63af5e-1aab-42eb-87c1-4768bc773e24"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="4605.75" y="166.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s582_sa354"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A heat shock 70kDa protein 1B HUGO:HSP1B heat shock 70kDa protein 1-like HUGO:HSPA1L Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453 References_end</body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="4580.75" y="229.0"/> </glyph> <glyph class="macromolecule" id="s583_sa355"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: STIP1 homology and U-box containing protin 1, E3 ubiquitin protein ligase HUGO:STUB1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453, PMID:25487024 References_end</body> </html> </notes> <label text="STUB1"/> <bbox w="80.0" h="40.0" x="4478.25" y="231.5"/> </glyph> </glyph> <glyph class="complex" id="s594_csa48" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:ABL1/TERT Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10837221 References_end</body> </html> </notes> <label text="ABL1/TERT"/> <bbox w="100.0" h="120.0" x="3121.8333" y="292.5"/> <glyph class="macromolecule" id="s452_sa350"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="3134.8333" y="303.5"/> <glyph class="state variable" id="_ea99987d-39b9-472d-84eb-da0604ef93d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3167.3345" y="338.5"/> </glyph> <glyph class="state variable" id="_b01f5bf1-68e5-4f83-8a85-51d0697ebd0a"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="3157.4624" y="298.5"/> </glyph> <glyph class="state variable" id="_f19e0a02-0a8a-4341-86b0-4388162154cb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3127.3333" y="318.46814"/> </glyph> </glyph> <glyph class="macromolecule" id="s595_sa351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: ABL proto-oncongene 1, non receptor tyrosine-kinase HUGO:ABL1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10837221 References_end</body> </html> </notes> <label text="ABL1"/> <bbox w="80.0" h="40.0" x="3135.8333" y="353.5"/> </glyph> </glyph> <glyph class="complex" id="s611_csa61" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:R2TP_complex ALT_NAME:PIH1D1/RPAP3/Pontin/Reptin Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="R2TP_Complex"/> <bbox w="218.0" h="166.0" x="3104.0" y="2766.0"/> <glyph class="macromolecule" id="s530_sa410"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: PIH1 domain containing 1 HUGO:PIH1D1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="PH1D1"/> <bbox w="80.0" h="40.0" x="3116.0" y="2786.0"/> </glyph> <glyph class="macromolecule multimer" id="s612_sa411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like AAA ATPase 1 HUGO:RUVBL1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="Pontin*"/> <bbox w="92.0" h="52.0" x="3116.0" y="2842.5"/> <glyph class="unit of information" id="_bb380012-fa0d-49b0-a178-88b3ec9c4cb1"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="3152.0" y="2837.5"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s613_sa412"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like AAA ATPase 2 HUGO:RUVBL2 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="Reptin*"/> <bbox w="92.0" h="52.0" x="3220.0" y="2843.5"/> <glyph class="unit of information" id="_94373332-948e-4943-b1ea-d1c95268e30f"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="3256.0" y="2838.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s614_sa413"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RNA polymerase II associated protein 3 HUGO:RPAP3 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="RPAP3"/> <bbox w="80.0" h="40.0" x="3215.0" y="2785.0"/> </glyph> </glyph> <glyph class="complex" id="s615_csa6" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:shelterin_complex ALT_NAME:POT1/RAP1A/Telomeric_DNA/TERF1/TERF2/TINF2/TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:18680434, PMID;16166375, PMID:19965504, PMID:18828880 References_end</body> </html> </notes> <label text="shelterin_complex"/> <bbox w="330.0" h="219.0" x="1119.0" y="1635.0"/> <glyph class="macromolecule multimer" id="s616_sa64"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor 2 HUGO:TERF2, HGNC:11728, ENTREZ:7014, UNIPROT:Q15554, GENECARDS:TERF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF2 PMID:9326951 References_end</body> </html> </notes> <label text="TERF2"/> <bbox w="86.0" h="46.0" x="1336.0" y="1732.0"/> <glyph class="unit of information" id="_c83e0c60-eb40-4d21-b9f3-406acfcb62e5"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1369.0" y="1727.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s617_sa65"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RAP1A, member of RAS oncogene family HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="1339.0" y="1785.0"/> </glyph> <glyph class="macromolecule" id="s71_sa66"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: TERF1 (TRF1-)interacting nuclear factor 2 HUGO:TINF2, HGNC:11824, ENTREZ:26277, UNIPROT:Q9BSI4, GENECARDS:TINF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of TINF2 PMID:10581025 References_end</body> </html> </notes> <label text="TINF2"/> <bbox w="80.0" h="40.0" x="1249.0" y="1655.0"/> <glyph class="state variable" id="_f113e1bd-938b-4fc5-8852-3374d5775292"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="1239.0" y="1669.9681"/> </glyph> </glyph> <glyph class="macromolecule" id="s618_sa67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: tripeptidyl peptidase I HUGO:TPP1, HGNC:2073, ENTREZ:1200, UNIPROT:O14773, GENECARDS:TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504 Identification of TPP1 PMID:15231715 References_end</body> </html> </notes> <label text="TPP1"/> <bbox w="80.0" h="40.0" x="1129.0" y="1695.0"/> </glyph> <glyph class="macromolecule" id="s619_sa68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: protection of telomere 1 HUGO:POT1, HGNC:17284, ENTREZ:25913, UNIPROT:Q9NUX5, GENECARDS:POT1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of POT1 PMID:11349150 References_end</body> </html> </notes> <label text="POT1"/> <bbox w="80.0" h="40.0" x="1129.0" y="1745.0"/> </glyph> <glyph class="nucleic acid feature" id="s620_sa69"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Telomeric DNA Telomeric DNA under t-loop conformation Telomeric DNA with G-quadruplexes Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:24993696, PMID:21209389, PMID:18680434 References_end</body> </html> </notes> <label text="Telomeric_DNA*"/> <bbox w="115.0" h="22.5" x="1216.5" y="1754.75"/> </glyph> <glyph class="macromolecule multimer" id="s621_sa70"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="1226.0" y="1702.0"/> <glyph class="unit of information" id="_b3e02329-878a-4438-95ee-05d67f0ab1b5"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1259.0" y="1697.0"/> </glyph> <glyph class="state variable" id="_558b32f4-1c04-4a14-8368-186a4da48c5f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1307.0" y="1720.0"/> </glyph> <glyph class="state variable" id="_f4880fdd-3eeb-46ad-bebc-ab18a2f1cbbd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1221.0" y="1720.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s622_csa1" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:shelterin_complex ALT_NAME:POT1/RAP1A/Telomeric_DNA/TERF1/TERF2/TINF2/TPP1 Identifiers_end Modules_begin: MODULE:SHELTERIN Modules_end References_begin: PMID:18680434, PMID;16166375, PMID:19965504, PMID:18828880 References_end</body> </html> </notes> <label text="shelterin_complex"/> <bbox w="330.0" h="200.0" x="649.0" y="1635.0"/> <glyph class="macromolecule multimer" id="s560_sa29"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor (NIMA-interacting) 1 HUGO:TERF1, HGNC:11728, ENTREZ:7013, UNIPROT:P54274, GENECARDS:TERF1 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF1 PMID:7502076 References_end</body> </html> </notes> <label text="TERF1*"/> <bbox w="86.0" h="46.0" x="756.0" y="1702.0"/> <glyph class="unit of information" id="_4c36fd10-be7c-472f-b109-7ea5df0a7930"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="789.0" y="1697.0"/> </glyph> <glyph class="state variable" id="_88b2cd4d-bc4e-4444-aa84-268146dadf0b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="837.0" y="1720.0"/> </glyph> 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: TERF1 (TRF1-)interacting nuclear factor 2 HUGO:TINF2, HGNC:11824, ENTREZ:26277, UNIPROT:Q9BSI4, GENECARDS:TINF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of TINF2 PMID:10581025 References_end</body> </html> </notes> <label text="TINF2"/> <bbox w="80.0" h="40.0" x="779.0" y="1655.0"/> <glyph class="state variable" id="_f77eb774-aaa9-4151-9201-9d1df5f640d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="774.0" y="1669.9681"/> </glyph> </glyph> <glyph class="macromolecule" id="s627_sa14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RAP1A, member of RAS oncogene family HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID;16166375, PMID:19965504 Identification of RAP1A PMID:10850490 References_end</body> </html> </notes> <label text="RAP1A"/> <bbox w="80.0" h="40.0" x="869.0" y="1785.0"/> </glyph> <glyph class="macromolecule multimer" id="s628_sa13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomeric repeat binding factor 2 HUGO:TERF2, HGNC:11728, ENTREZ:7014, UNIPROT:Q15554, GENECARDS:TERF2 Identifiers_end Modules_begin: MODULE:SHELTERIN MODULE:REPLICATION Modules_end References_begin: Reviews PMID:18680434, PMID:16166375, PMID:19965504, PMID:22634377 Identification of TERF2 PMID:9326951 References_end</body> </html> </notes> <label text="TERF2"/> <bbox w="86.0" h="46.0" x="866.0" y="1732.0"/> <glyph class="unit of 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</notes> <label text="NHP2"/> <bbox w="80.0" h="40.0" x="4228.5" y="2321.5"/> </glyph> <glyph class="macromolecule" id="s631_sa403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: dyskeratosis congenita 1, dyskerin HUGO:DKC1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="DKC1"/> <bbox w="80.0" h="40.0" x="4318.5" y="2321.5"/> </glyph> <glyph class="macromolecule" id="s632_sa404"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NOP10 ribonucleoprotein HUGO:NOP10 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NOP10"/> <bbox w="80.0" h="40.0" x="4228.5" y="2371.5"/> </glyph> <glyph class="macromolecule" id="s633_sa405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: nuclear assembly factor 1 ribonucleoprotein HUGO:NAF1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="NAF1"/> <bbox w="80.0" h="40.0" x="4318.5" y="2371.5"/> </glyph> <glyph class="nucleic acid feature" id="s522_sa406"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>nascent TERC RNA ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: telomerase RNA component HUGO:TERC Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERC"/> <bbox w="90.0" h="25.0" 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<title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="3639.0" y="597.0"/> <glyph class="state variable" id="_520b4de8-f105-4bd0-92f7-2e2dc8dac6fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3671.5012" y="632.0"/> </glyph> <glyph class="state variable" id="_b19cd9c9-1125-4b71-a916-e61611cf885f"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="3661.6292" y="592.0"/> </glyph> <glyph class="state variable" id="_f37905c1-61e9-4171-9ba5-0e146ac35cb5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3634.0" y="611.96814"/> </glyph> </glyph> <glyph class="macromolecule" id="s635_sa276"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>prostaglandin E synthase 3 (cytosolic) HUGO:PTGES3 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:10197982 References_end</body> </html> </notes> <label text="PTGES3"/> <bbox w="80.0" h="40.0" x="3699.0" y="647.0"/> </glyph> <glyph class="macromolecule multimer" id="s636_sa277"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:21945180 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="86.0" h="46.0" x="3736.0" y="594.0"/> <glyph class="unit of information" id="_27a1d909-7ad2-4e7f-99de-f30112783bdb"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="3769.0" y="589.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s637_csa39" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:HSP70*/HSP90*/STUB1/TERT Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:20959453 References_end</body> </html> </notes> <label text="HSP70*/HSP90*/STUB1/TERT"/> <bbox w="265.0" h="175.0" x="4039.5" y="154.5"/> <glyph class="macromolecule" id="s459_sa300"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: telomerase reverse transcriptase Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:23551398 References_end</body> </html> </notes> <label text="TERT"/> <bbox w="80.0" h="40.0" x="4049.5" y="174.5"/> <glyph class="state variable" id="_f871e92f-ef65-4810-8b61-b0998bf70c3c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4082.0012" y="209.5"/> </glyph> <glyph class="state variable" 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y="2836.5588"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s570_sa416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like AAA ATPase 2 HUGO:RUVBL2 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="Reptin*"/> <bbox w="92.0" h="52.0" x="3521.2942" y="2842.5588"/> <glyph class="unit of information" id="_dd7f88e0-c725-47bf-9f24-851c5495d124"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="3557.2942" y="2837.5588"/> </glyph> </glyph> <glyph class="macromolecule" id="s571_sa417"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RNA polymerase II associated protein 3 HUGO:RPAP3 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="RPAP3"/> <bbox w="80.0" h="40.0" x="3516.2942" y="2784.0588"/> </glyph> </glyph> <glyph class="complex" id="s654_csa65" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: NAME:Pontin_Reptin_Hexamer ALT_NAME:PIH1D1/RPAP3/Pontin/Reptin Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="R2TP_Complex_without_PIH1D1"/> <bbox w="224.0" h="106.0" x="3710.2942" y="2823.0588"/> <glyph class="macromolecule multimer" id="s655_sa426"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like AAA ATPase 1 HUGO:RUVBL1 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end</body> </html> </notes> <label text="Pontin*"/> <bbox 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<head> <title/> </head> <body>Identifiers_begin: RNA polymerase II associated protein 3 HUGO:RPAP3 Identifiers_end Modules_begin: MODULE:TELOMERASE Modules_end References_begin: PMID:22923768 References_end</body> </html> </notes> <label text="RPAP3"/> <bbox w="80.0" h="40.0" x="3637.2942" y="2715.0588"/> </glyph> <glyph class="macromolecule" id="s659_sa430" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Chromobox 3 HUGO:CBX3, HGNC:1553 Identifiers_end Modules_begin: MODULE:REPLICATION Modules_end References_begin: PMID:21865325 This protein binds to TIN2, enhancing telomere cohesion. References_end</body> </html> </notes> <label text="CBX3"/> <bbox w="80.0" h="40.0" x="1605.0" y="1244.0"/> </glyph> <glyph class="simple chemical" id="s661_sa432" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: Deoxythymidine 5'-triphosphate CHEBI:18077 Identifiers_end Modules_begin: MODULE:REPLICATION Modules_end</body> </html> </notes> <label text="dTTP"/> <bbox w="70.0" h="25.0" x="1748.0" y="2454.5"/> </glyph> <glyph class="simple chemical" id="s662_sa433" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: 2'-deoxyguanosine 5'-triphosphate CHEBI:16497 Identifiers_end Modules_begin: MODULE:REPLICATION Modules_end</body> </html> </notes> <label text="dGTP"/> <bbox w="70.0" h="25.0" x="1753.0" y="2492.5"/> 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class="process" orientation="vertical" id="pr_f36a8a48-0dec-45bc-a8c1-8a5136c74dd2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>References_begin: PMID:25845889 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="531.5" y="2188.75"/> <port id="pr_f36a8a48-0dec-45bc-a8c1-8a5136c74dd2_p1" x="536.5" y="2208.75"/> <port id="pr_f36a8a48-0dec-45bc-a8c1-8a5136c74dd2_p2" x="536.5" y="2178.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5dc7befe-116b-4b9f-899e-a45e4af7a959"> <bbox w="10.0" h="10.0" x="813.0" y="2015.5"/> <port id="pr_5dc7befe-116b-4b9f-899e-a45e4af7a959_p1" x="818.0" y="2005.5"/> <port id="pr_5dc7befe-116b-4b9f-899e-a45e4af7a959_p2" x="818.0" y="2035.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cb6bf95e-7b2b-4171-95d8-7f03a8a15b9a"> <bbox w="10.0" h="10.0" x="340.5" y="2049.75"/> <port 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id="pr_040f1960-3b1a-4521-b3d9-3a8fd57a1567"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Reviews about TERT transcription regulation PMID:21790308, PMID:22381618, PMID:18754863 About MYC and MXD1 regulation PMID:11274400 About estrogen regulation PMID:10606235 About NFAT regulation PMID:19846528 About ETV1 regulation: PMID:14673140 About cortisol regulation: PMID:18222063 About beta-catenin regulation: PMID:22723415</body> </html> </notes> <bbox w="10.0" h="10.0" x="4485.0" y="1514.4326"/> <port id="pr_040f1960-3b1a-4521-b3d9-3a8fd57a1567_p1" x="4475.0" y="1519.4326"/> <port id="pr_040f1960-3b1a-4521-b3d9-3a8fd57a1567_p2" x="4505.0" y="1519.4326"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7fca2a16-d191-4703-84d3-f452059c9aad"> <bbox w="10.0" h="10.0" x="3323.5" y="583.43286"/> <port id="pr_7fca2a16-d191-4703-84d3-f452059c9aad_p1" x="3313.5" y="588.43286"/> <port 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