</head> <body>Regulated Cell Death map The map represents mechanisms involved in all documented modes of regulated cell death (RCD). The map depicts biochemical triggers and upstream signalling as death receptors; mitochondria, glucose metabolism and DNA damage initiating different modes of programmed cell death. An addition layer of cell death signalling regulation by miRNAs is described on the map as well. The molecular mechanism executing each programmed cell death mode is represented in details. The map is composed of 26 functional modules. 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID: 23069999 </body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="7937.75" y="843.75"/> </label> <bbox w="187.5" h="797.5" x="7936.25" y="831.25"/> </glyph> <glyph class="compartment" id="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID: 23069999 </body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="9548.5" y="408.5"/> </label> <bbox w="260.0" h="150.0" x="9490.0" y="295.0"/> </glyph> <glyph class="compartment" id="c17_ca17"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="7884.0" y="1276.0"/> </label> <bbox w="12004.0" h="8230.0" x="16.0" y="30.0"/> </glyph> <glyph 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</glyph> <glyph class="compartment" id="c8_ca8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>GO:0030141 </body> </html> </notes> <label text="Secretory Granule"> <bbox w="90.0" h="10.0" x="727.75" y="433.5"/> </label> <bbox w="460.0" h="130.0" x="450.0" y="360.0"/> </glyph> <glyph class="compartment" id="c16_ca16" compartmentRef="c13_ca13"> <label text="Site of DNA damage"> <bbox w="95.0" h="10.0" x="584.0" y="7477.5"/> </label> <bbox w="962.5" h="410.0" x="560.0" y="7465.0"/> </glyph> <glyph class="compartment" id="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>not a compartment, but a dynamical protein complex that is assembled at the cytosolic part of TNFRSF1A upon ligand 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x="130.0" y="220.0"/> </glyph> <glyph class="phenotype" id="s1_sa2" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: mitochondrial outer membrane permeabilization PMID:26801188 Ceramide channels and mitochondrial outer membrane permeability References_end </body> </html> </notes> <label text="MOMP"/> <bbox w="80.0" h="30.0" x="5011.1987" y="6158.569"/> </glyph> <glyph class="simple chemical" id="s2_sa2821" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37037 Identifiers_end </body> </html> </notes> <label text="pyrimidine 2'-deoxyribonucleoside 5'-diphosphate"/> <bbox w="305.0" h="32.5" x="2067.5" y="2893.75"/> </glyph> <glyph class="macromolecule" id="s5_sa5" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HtrA serine peptidase 2 HUGO:HTRA2 HGNC:14348 ENTREZ:27429 UNIPROT:O43464 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end References_begin: uniprot:O43464 PMID:23070005 References_end </body> </html> </notes> <label text="HTRA2"/> <bbox w="80.0" h="40.0" x="3814.9485" y="3930.5688"/> </glyph> <glyph class="macromolecule" id="s6_sa3116" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DAB2 interacting protein HUGO:DAB2IP HGNC:17294 ENTREZ:153090 UNIPROT:Q5VWQ8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:AIP1 PMID:15310755 AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation References_end </body> </html> </notes> <label text="DAB2IP"/> <bbox w="80.0" h="40.0" x="4960.0" y="450.0"/> <glyph class="state variable" id="_9d2fa6e0-1f37-4c23-9e17-4060221c46e2"> <state value="" variable="S604"/> <bbox w="30.0" h="10.0" x="5001.949" y="445.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7_sa3166" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 4 HUGO:MAP2K4 HGNC:6844 ENTREZ:6416 UNIPROT:P45985 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:MKK4 synonym:MEK4 References_end </body> </html> </notes> <label text="MAP2K4"/> <bbox w="80.0" h="40.0" x="4908.0" y="1918.0"/> <glyph class="state variable" id="_dc544461-f2fb-4423-ac57-d928c07def45"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4959.5684" y="1913.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8_sa3218" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: K48-linked ubiquitin chains References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="4933.0" y="795.25"/> <glyph class="state variable" id="_fd11ad67-c6bf-4d20-82db-4925e0853aed"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4923.0" y="801.42114"/> </glyph> <glyph class="state variable" id="_1bc760a4-a0da-4fe3-b8d2-d3d796147795"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="4998.0" y="801.5"/> </glyph> <glyph class="state variable" id="_72679b9a-7d8f-4ea6-acd1-7786191110be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4970.8364" y="790.25"/> </glyph> <glyph class="state variable" id="_ba8922af-8873-49d8-b1ba-5dc283f4d5c4"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="4974.3306" y="830.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s9_sa9" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="3825.9485" y="4165.569"/> <glyph class="state variable" id="_75ea3357-de91-440f-8381-95a239e70b1d"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="3834.5435" y="4160.569"/> </glyph> <glyph class="state variable" id="_aa0d8d76-c533-4951-a5b4-d9324460e068"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="3867.8977" y="4160.569"/> </glyph> <glyph class="state variable" id="_c7c5f97a-67f0-404a-b985-80ef0d8aad1c"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="3867.279" y="4200.569"/> </glyph> <glyph class="state variable" id="_96cbea82-987d-43ba-bb9e-8d9c0e0f54ca"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="3833.924" y="4200.569"/> </glyph> <glyph class="state variable" id="_7ae9717e-e0eb-4de5-9aa5-175ad66cb50a"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="3893.4485" y="4180.569"/> </glyph> <glyph class="state variable" 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interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4884.063" y="5964.0356"/> </glyph> <glyph class="macromolecule" id="s4585_sa3545"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4894.063" y="5974.0356"/> </glyph> <glyph class="macromolecule" id="s4585_sa3546"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4904.063" y="5984.0356"/> </glyph> <glyph class="macromolecule" id="s4585_sa3551"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4842.063" y="5954.0356"/> </glyph> <glyph class="macromolecule" id="s4585_sa3552"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4852.063" y="5964.0356"/> </glyph> <glyph class="macromolecule" id="s4585_sa3553"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4862.063" y="5974.0356"/> </glyph> <glyph class="macromolecule" id="s4585_sa3554"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="4872.063" y="5984.0356"/> </glyph> </glyph> <glyph class="macromolecule" id="s15_sa74" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:14-3-3 theta References_end </body> </html> </notes> <label text="YWHAQ"/> <bbox w="80.0" h="40.0" x="7418.0" y="4997.0"/> </glyph> <glyph class="macromolecule" id="s17_sa12" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HtrA serine peptidase 2 HUGO:HTRA2 HGNC:14348 ENTREZ:27429 UNIPROT:O43464 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end References_begin: uniprot:O43464 PMID:23070005 References_end </body> </html> </notes> <label text="HTRA2"/> <bbox w="80.0" h="40.0" x="6410.0" y="4690.0"/> </glyph> <glyph class="macromolecule" id="s18_sa1639" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4776.25" y="5432.0"/> <glyph class="state variable" id="_15da7da6-381a-476a-904f-8db84d22ad18"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4831.2446" y="5427.0"/> </glyph> <glyph class="state variable" 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y="5562.0"/> <glyph class="state variable" id="_0654c164-0517-4fe2-a31a-25d963ba36cd"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4650.1436" y="5557.0"/> </glyph> <glyph class="state variable" id="_0adbdc4e-d8e1-4b6c-8132-76b55ae90de7"> <state value="P" variable="S159"/> <bbox w="35.0" h="10.0" x="4601.3135" y="5557.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s22_sa1381" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6670.0" y="5830.0"/> </glyph> <glyph class="complex" id="s24_csa132" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:Cytochrome_C*:d Identifiers_end </body> </html> </notes> <label text="APOPTOSOME"/> <bbox w="230.0" h="150.0" x="6805.0" y="5625.0"/> <glyph class="macromolecule" id="s2512_sa1383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6879.059" y="5641.442"/> <glyph class="state variable" id="_a0b2e66d-7e7b-4614-a496-3e40fb2e4f55"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6891.559" y="5636.442"/> </glyph> </glyph> <glyph class="macromolecule" id="s2512_sa1384"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6889.059" y="5651.442"/> <glyph class="state variable" id="_ff78e875-db08-4836-9f40-209d3108822b"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6901.559" y="5646.442"/> </glyph> </glyph> <glyph class="macromolecule" id="s2512_sa1385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6899.059" y="5661.442"/> <glyph class="state variable" id="_3c375b10-a4e7-46fc-9129-7f6c871268c2"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6911.559" y="5656.442"/> </glyph> </glyph> <glyph class="macromolecule" id="s2512_sa1386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6909.059" y="5671.442"/> <glyph class="state variable" id="_2943d63a-529d-41c8-805f-66fbbe45b1d2"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6921.559" y="5666.442"/> </glyph> </glyph> <glyph class="macromolecule" id="s2512_sa1387"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6919.059" y="5681.442"/> <glyph class="state variable" id="_a13de24f-0449-4b51-9996-6eb2677f1846"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6931.559" y="5676.442"/> </glyph> </glyph> <glyph class="macromolecule" id="s2512_sa1388"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6929.059" y="5691.442"/> <glyph class="state variable" id="_3a6445b4-9342-4afa-b2cf-b0f96c880ad5"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6941.559" y="5686.442"/> </glyph> </glyph> <glyph class="macromolecule" id="s2513_sa1389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6813.636" y="5641.442"/> </glyph> <glyph class="macromolecule" id="s2513_sa1390"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6822.636" y="5655.442"/> </glyph> <glyph class="macromolecule" id="s2513_sa1391"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6839.636" y="5684.442"/> </glyph> <glyph class="macromolecule" id="s2513_sa1392"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6839.636" y="5684.442"/> </glyph> <glyph class="macromolecule" id="s2513_sa1394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6839.636" y="5684.442"/> </glyph> <glyph class="macromolecule" id="s2513_sa1395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6873.636" y="5703.442"/> </glyph> <glyph class="macromolecule" id="s2512_sa1396"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6939.059" y="5703.442"/> <glyph class="state variable" id="_c5fac684-a8e9-47a4-a131-b675ab03483e"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6951.559" y="5698.442"/> </glyph> </glyph> <glyph class="simple chemical" id="s4263_sa3094"> <label text="(d)ATP"/> <bbox w="70.0" h="25.0" x="6945.75" y="5648.25"/> </glyph> </glyph> <glyph class="simple chemical" id="s25_sa115" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15346 KEGGCOMPOUND:C00010 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="coenzyme A"/> <clone/> <bbox w="70.0" h="25.0" x="1441.75" y="5908.5"/> </glyph> <glyph class="simple chemical" id="s25_sa138" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15346 KEGGCOMPOUND:C00010 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. 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text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="1455.3333" y="5420.6846"/> </glyph> <glyph class="simple chemical" id="s30_sa342" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="1912.9982" y="5485.0"/> </glyph> <glyph class="simple chemical" id="s30_sa2020" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="825.0" y="6057.5"/> </glyph> <glyph class="simple chemical" id="s30_sa2777" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="1695.5131" y="6063.25"/> </glyph> <glyph class="simple chemical" id="s31_sa134" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="1004.75" y="5769.5"/> </glyph> <glyph class="simple chemical" id="s31_sa142" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="720.25" y="5825.5"/> </glyph> <glyph class="simple chemical" id="s31_sa205" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="1570.2227" y="5728.056"/> </glyph> <glyph class="simple chemical" id="s31_sa1996" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="1179.25" y="5672.5"/> </glyph> <glyph class="macromolecule" id="s32_sa1745" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pim-1 oncogene HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 pim-2 oncogene HUGO:PIM2 HGNC:8987 ENTREZ:11040 UNIPROT:Q9P1W9 pim-3 oncogene HUGO:PIM3 HGNC:19310 ENTREZ:415116 UNIPROT:Q86V86 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PIM*"/> <bbox w="80.0" h="40.0" x="2877.25" y="2735.6084"/> </glyph> <glyph class="simple chemical" id="s34_sa3000" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:27186 Identifiers_end References_begin: synonym:mitochondrial ubiquinones CHEBI definition: Naturally occurring lipid-soluble benzoquinones that are involved in electron transport in mitochondria. The polyprenyl chain consists of 6 to 12 isoprenoid units. References_end </body> </html> </notes> <label text="ubiquinone"/> <bbox w="70.0" h="25.0" x="495.74347" y="4480.375"/> </glyph> <glyph class="complex" id="s37_csa208" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BBC3:BCL2-XL* Identifiers_end </body> </html> </notes> <label text="BBC3:BCL2L1"/> <bbox w="99.75" h="118.0" x="4600.25" y="4312.0"/> <glyph class="macromolecule" id="s8065_sa1660"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="4610.0" y="4320.0"/> </glyph> <glyph class="macromolecule" id="s2996_sa1661"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="4610.0" y="4370.0"/> </glyph> </glyph> <glyph class="complex" id="s40_csa205" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BBC3:BCL2L2 Identifiers_end </body> </html> </notes> <label text="BBC3:BCL2L2"/> <bbox w="97.75" h="120.0" x="4602.25" y="4450.0"/> <glyph class="macromolecule" id="s2969_sa1654"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="4610.0" y="4510.0"/> </glyph> <glyph class="macromolecule" id="s2941_sa1655"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="4610.0" y="4460.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s41_sa145" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30031 KEGGCOMPOUND:C00042 CAS:56-14-4 Identifiers_end References_begin: charge:2- References_end </body> </html> </notes> <label text="succinate"/> <bbox w="70.0" h="25.0" x="641.75" y="5568.5"/> </glyph> <glyph class="simple chemical" id="s43_sa129" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15595 KEGGCOMPOUND:C00711 CAS:149-61-1 Identifiers_end References_begin: charge:2- References_end </body> </html> </notes> <label text="malate"/> <bbox w="70.0" h="25.0" x="1112.75" y="5557.5"/> </glyph> <glyph class="simple chemical" id="s46_sa121" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16452 KEGGCOMPOUND:C00036 CAS:149-63-3 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="oxaloacetate"/> <bbox w="70.0" h="25.0" x="1332.75" y="5554.5"/> </glyph> <glyph class="macromolecule" id="s51_sa3118" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DAB2 interacting protein HUGO:DAB2IP HGNC:17294 ENTREZ:153090 UNIPROT:Q5VWQ8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:AIP1 PMID:15310755 AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation References_end </body> </html> </notes> <label text="DAB2IP"/> <bbox w="80.0" h="40.0" x="4993.0" y="715.25"/> <glyph class="state variable" id="_adc59aa7-f681-4be0-8e03-7746c328874b"> <state value="P" variable="S604"/> <bbox w="35.0" h="10.0" x="5032.449" y="710.25"/> </glyph> </glyph> <glyph class="simple chemical" id="s52_sa140" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16810 KEGGCOMPOUND:C00026 CAS:64-15-3 Identifiers_end </body> </html> </notes> <label text="2-oxoglutarate"/> <bbox w="70.0" h="25.0" x="917.75" y="5774.5"/> </glyph> <glyph class="complex" id="s55_csa199" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2L2 Identifiers_end </body> </html> </notes> <label text="BAD:BCL2L2"/> <bbox w="100.0" h="120.0" x="5580.0" y="4460.0"/> <glyph class="macromolecule" id="s57_sa1642"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="5588.25" y="4518.3335"/> </glyph> <glyph class="macromolecule" id="s56_sa1643"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="5590.0" y="4471.3335"/> <glyph class="state variable" id="_ca5bc4bf-e675-4776-84f2-d202591af0e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5608.595" y="4466.3335"/> </glyph> <glyph class="state variable" id="_e415bc5f-1049-4837-97be-49f04c213af3"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="5631.949" y="4466.3335"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s59_csa201" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2A1:PMAIP1 Identifiers_end </body> </html> </notes> <label text="BCL2A1:PMAIP1"/> <bbox w="101.75" h="124.0" x="4218.25" y="5246.0"/> <glyph class="macromolecule" id="s61_sa1646"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-related protein A1 HUGO:BCL2A1 HGNC:991 ENTREZ:597 UNIPROT:Q16548 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2A1"/> <bbox w="80.0" h="40.0" x="4225.5" y="5256.0"/> </glyph> <glyph class="macromolecule" id="s2994_sa1647"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:NOXA References_end </body> </html> </notes> <label text="PMAIP1"/> <bbox w="80.0" h="40.0" x="4226.25" y="5301.0"/> </glyph> </glyph> <glyph class="complex" id="s62_csa4" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAK1:IGFBP1 Identifiers_end </body> </html> </notes> <label text="BAK1:IGFBP1"/> <bbox w="100.0" h="120.0" x="5280.0" y="5830.0"/> <glyph class="macromolecule" id="s2851_sa44"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: insulin-like growth factor binding protein 1 HUGO:IGFBP1 HGNC:5469 ENTREZ:3484 UNIPROT:P08833 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="IGFBP1"/> <bbox w="80.0" h="40.0" x="5290.5483" y="5880.3486"/> </glyph> <glyph class="macromolecule" id="s2852_sa45"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="5291.5483" y="5837.3486"/> </glyph> </glyph> <glyph class="macromolecule" id="s65_sa1756" compartmentRef="c1_ca1"> <notes> <html 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MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4354.6216" y="5728.121"/> <glyph class="state variable" 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containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="80.0" h="40.0" x="7690.0" y="3690.0"/> <glyph class="state variable" id="_fb349e9a-4acb-48f2-a857-25277030cf30"> <state value="" variable="T34"/> <bbox w="25.0" h="10.0" x="7734.449" y="3685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s74_sa50" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="6030.0" y="2780.0"/> <glyph class="state variable" id="_c554746a-f62c-4b2b-bf51-f5f7272bd132"> <state value="P" variable="T167"/> <bbox w="35.0" h="10.0" x="6028.577" y="2775.0"/> </glyph> <glyph class="state variable" id="_f4c21f4e-7bc1-407a-9986-3d5108b3021b"> <state value="P" variable="S163"/> <bbox w="35.0" h="10.0" x="6073.5845" y="2775.0"/> </glyph> <glyph class="state variable" id="_c488681d-c0c0-4193-88cc-384f4a79c5da"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="6076.3213" y="2815.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s75_sa51" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <clone/> <bbox w="80.0" h="40.0" x="6160.0" y="4950.0"/> </glyph> <glyph class="macromolecule" id="s75_sa5431" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <clone/> <bbox w="80.0" h="40.0" x="11710.0" y="850.0"/> </glyph> <glyph class="macromolecule" id="s75_sa5436" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <clone/> <bbox w="80.0" h="40.0" x="11540.0" y="360.0"/> </glyph> <glyph class="macromolecule" id="s75_sa5445" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <clone/> <bbox w="80.0" h="40.0" x="11260.0" y="370.0"/> </glyph> <glyph class="macromolecule" id="s75_sa5449" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <clone/> <bbox w="80.0" h="40.0" x="10750.0" y="310.0"/> </glyph> <glyph class="macromolecule" id="s75_sa5453" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <clone/> <bbox w="80.0" h="40.0" x="10970.0" y="350.0"/> </glyph> <glyph class="macromolecule" id="s83_sa48" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="5670.0" y="2780.0"/> <glyph class="state variable" id="_76ef6519-fe68-476d-b189-7a93349cb571"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="5671.077" y="2775.0"/> </glyph> <glyph class="state variable" id="_368e2734-72d7-4e88-b7e6-83e3bbf43020"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="5716.0845" y="2775.0"/> </glyph> <glyph class="state variable" id="_ab0ffb68-e49f-4bc5-b6df-6cb4efc117e9"> <state value="P" variable="S184"/> <bbox w="35.0" h="10.0" x="5713.8213" y="2815.0"/> </glyph> </glyph> <glyph class="source and sink" id="s84_sa49" 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synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <clone/> <bbox w="80.0" h="40.0" x="5865.5" y="6925.0"/> </glyph> <glyph class="macromolecule" id="s86_sa3730" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <clone/> <bbox w="80.0" h="40.0" x="2800.0" y="1550.0"/> </glyph> <glyph class="macromolecule" id="s86_sa4465" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <clone/> <bbox w="80.0" h="40.0" x="9620.0" y="1910.0"/> </glyph> <glyph class="macromolecule" id="s86_sa4485" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <clone/> <bbox w="80.0" h="40.0" x="11501.0" y="2104.5"/> </glyph> <glyph class="simple chemical" id="s96_sa336" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="1414.3333" y="4341.6846"/> </glyph> <glyph class="simple chemical" id="s96_sa387" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="1766.75" y="4321.33"/> </glyph> <glyph class="simple chemical" id="s96_sa409" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="1710.25" y="4319.75"/> </glyph> <glyph class="simple chemical" id="s96_sa2230" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="1561.75" y="4044.5"/> </glyph> <glyph class="simple chemical" id="s96_sa2520" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="3201.25" y="4351.5"/> </glyph> <glyph class="simple chemical" id="s96_sa2524" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="3432.25" y="4339.5"/> </glyph> <glyph class="simple chemical" id="s96_sa2527" compartmentRef="c3_ca3"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="3531.25" y="4341.5"/> </glyph> <glyph class="complex" id="s99_csa6" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:Ku70* Identifiers_end </body> </html> </notes> <label text="BAX:XRCC6"/> <bbox w="102.5" h="120.0" x="6008.75" y="2850.0"/> <glyph class="macromolecule" id="s100_sa68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6 HGNC:4055 ENTREZ:2547 UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:Ku70 References_end </body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="6021.25" y="2910.0"/> <glyph class="state variable" id="_d3af3eab-b419-4e4d-95d0-d125f20a1230"> <state value="" variable="K542"/> <bbox w="30.0" h="10.0" x="6086.25" y="2905.2148"/> </glyph> <glyph class="state variable" id="_cac8ff47-f4b1-4510-bf50-07ad48684540"> <state value="" variable="K539"/> <bbox w="30.0" h="10.0" x="6006.7427" y="2905.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7608_sa69"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="6018.1484" y="2858.51"/> <glyph class="state variable" id="_3f129f13-a6fe-41b7-a053-064572b06988"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="6019.2256" y="2853.51"/> </glyph> <glyph class="state variable" id="_775e4150-5f7d-404e-90dd-4ba963ab8cc2"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="6064.233" y="2853.51"/> </glyph> <glyph class="state variable" id="_fb8179b5-9fa8-4349-8a1e-9efe4e1b7134"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="6064.4697" y="2893.51"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s102_sa1366" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6 HGNC:4055 ENTREZ:2547 UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:Ku70 References_end </body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="812.5" y="7375.0"/> <glyph class="state variable" id="_4fda68dc-525c-4673-a220-f87588b2c4ff"> <state value="Ac" variable="K542"/> <bbox w="40.0" h="10.0" x="872.5" y="7370.215"/> </glyph> <glyph class="state variable" id="_8a11f63a-508a-41ff-baf5-c15906ad3b6c"> <state value="Ac" variable="K539"/> <bbox w="40.0" h="10.0" x="792.9925" y="7370.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s104_sa57" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6 HGNC:4055 ENTREZ:2547 UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:Ku70 References_end </body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="5860.0" y="2980.0"/> <glyph class="state variable" id="_0971db49-2998-49df-a19f-def567d72d95"> <state value="" variable="K542"/> <bbox w="30.0" h="10.0" x="5925.0" y="2975.2148"/> </glyph> <glyph class="state variable" id="_b21c5261-9530-40bc-9ef4-827d16afe897"> <state value="" variable="K539"/> <bbox w="30.0" h="10.0" x="5845.4927" y="2975.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s108_sa59" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded 16S RNA HUGO:MT-RNR2 HGNC:7471 ENTREZ:4550 UNIPROT:Q8IVG9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="humanin*"/> <bbox w="80.0" h="40.0" x="5860.0" y="2590.0"/> </glyph> <glyph class="complex" id="s109_csa8" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:humanin* Identifiers_end </body> </html> </notes> <label text="BAX:humanin"/> <bbox w="100.0" h="120.0" x="5990.0" y="2610.0"/> <glyph class="macromolecule" id="s111_sa72"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded 16S RNA HUGO:MT-RNR2 HGNC:7471 ENTREZ:4550 UNIPROT:Q8IVG9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="humanin*"/> <bbox w="80.0" h="40.0" x="6000.3984" y="2665.3792"/> </glyph> <glyph class="macromolecule" id="s7587_sa73"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="6000.3984" y="2619.3792"/> <glyph class="state variable" id="_da6d06e3-05f0-4e3c-b7f2-6aee56a89887"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="6001.4756" y="2614.3792"/> </glyph> <glyph class="state variable" id="_0a315a3d-c847-4795-9c12-249d7a3855e4"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="6046.483" y="2614.3792"/> </glyph> <glyph class="state variable" id="_f2b81946-cd85-4343-adf6-42365c3f563f"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="6046.7197" y="2654.3792"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s118_csa7" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAX Identifiers_end </body> </html> </notes> <label text="14-3-3:BAX"/> <bbox w="100.0" h="120.0" x="6010.0" y="3000.0"/> <glyph class="macromolecule" id="s116_sa70"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6020.0" y="3010.0"/> <glyph class="state variable" id="_7af1c4cd-8328-40bb-8481-6e576d5eece2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6071.5977" y="3005.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s115_sa71"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="6020.0" y="3050.0"/> <glyph class="state variable" id="_f6bfb918-af4d-45c2-8ad5-b58cb5b4d271"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="6021.077" y="3045.0"/> </glyph> <glyph class="state variable" id="_39e3fa4b-7932-4345-8d3f-13d014384f17"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="6066.0845" y="3045.0"/> </glyph> <glyph class="state variable" id="_6df34a81-edb4-44bb-a15a-851c4c89cf8c"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="6066.3213" y="3085.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s124_sa53" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="7520.0" y="4780.0"/> <glyph class="state variable" id="_d04de35a-312b-4e81-b0d0-9bf025d529a4"> <state value="P" variable=""/> <bbox 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compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4780.0" y="5560.0"/> <glyph class="state variable" id="_5a23f031-8dbb-4b65-aa2e-b409c3d7aedf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4834.9946" y="5555.0"/> </glyph> <glyph 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Maps_Modules_end References_begin: synonym:MULE References_end </body> </html> </notes> <label text="HECTH9*"/> <bbox w="80.0" h="40.0" x="4570.0" y="3580.0"/> </glyph> <glyph class="source and sink" id="s131_sa103" compartmentRef="c4_ca4"> <label text="s131"/> <bbox w="30.0" h="30.0" x="4525.5" y="5566.5"/> </glyph> <glyph class="macromolecule" id="s132_sa1003" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GSK3α*"/> <bbox w="80.0" h="40.0" x="7984.0" y="1922.0"/> <glyph class="state variable" id="_1ad92804-c13f-4863-998b-e75137bbea31"> <state value="" variable="S21"/> <bbox w="25.0" h="10.0" x="7991.5825" y="1917.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s133_sa1002" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GSK3α*"/> <bbox w="80.0" h="40.0" x="7805.5" y="1919.0"/> <glyph class="state variable" id="_9d366041-e580-4dea-81a2-2c108beba1e2"> <state value="P" variable="S21"/> <bbox w="30.0" h="10.0" x="7810.5825" y="1914.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s136_sa482" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) HUGO:GZMB HGNC:4709 ENTREZ:3002 UNIPROT:P10144 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GZMB"/> <bbox w="80.0" h="40.0" x="6710.0" y="2350.0"/> </glyph> <glyph class="nucleic acid feature" id="s139_sa508" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES 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id="_00e9f415-d8b0-46ec-887d-d278419f8d9b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3578.1753" y="7078.492"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s141_sa104" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 Identifiers_end </body> </html> </notes> <label text="MIR29B1"/> <bbox w="90.0" h="25.0" x="1769.6754" y="6641.992"/> <glyph class="unit of information" id="_6a147af2-69c0-4c5c-8051-18274afea139"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1799.6754" y="6636.992"/> </glyph> </glyph> <glyph class="macromolecule" id="s145_sa1635" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5350.0" y="4190.0"/> <glyph class="state variable" id="_a3d6f45f-c060-46b3-8f85-bc237f7268f3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5368.4316" y="4185.0"/> </glyph> <glyph 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MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2"/> <clone/> <bbox w="90.0" h="25.0" x="3694.0" y="7081.5"/> <glyph class="unit of information" id="_f790bc1b-eb95-4544-9dde-7fbc958b27f0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3729.0" y="7076.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s146_sa4740" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2"/> <clone/> <bbox w="90.0" h="25.0" x="9050.703" y="7063.75"/> <glyph class="unit of information" id="_d1e54942-d647-4ef5-9081-18e7f3498546"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9085.703" y="7058.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s148_sa504" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 15a HUGO:MIR15A HGNC:31543 ENTREZ:406948 Identifiers_end References_begin: PMID:23070007 References_end </body> </html> </notes> <label text="MIR15A"/> <bbox w="90.0" h="25.0" x="2211.3494" y="6644.2344"/> <glyph class="unit of information" id="_dc1f4de7-bf22-40b5-b46f-d48f0d0a123e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2241.3494" y="6639.2344"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s149_sa503" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 16-1 HUGO:MIR16-1 HGNC:31545 ENTREZ:406950 Identifiers_end References_begin: PMID:23070007 References_end </body> </html> </notes> <label text="MIR16-1"/> <bbox w="90.0" h="25.0" x="2521.3494" y="6633.2344"/> <glyph class="unit of information" id="_df2dc60b-f597-404b-b4a6-3e78707a3826"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2551.3494" y="6628.2344"/> </glyph> </glyph> <glyph class="macromolecule" id="s157_sa58" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase C, zeta HUGO:PRKCZ HGNC:9412 ENTREZ:5590 UNIPROT:Q05513 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PRKCZ"/> <bbox w="80.0" h="40.0" x="5760.0" y="2890.0"/> </glyph> <glyph class="macromolecule" id="s172_sa110" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4779.25" y="5660.0"/> <glyph class="state variable" id="_bda61e40-e04c-4159-8571-a1c6c90d0ff7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4834.2446" y="5655.0"/> </glyph> <glyph class="state variable" id="_960cbb17-f078-4bfe-bae0-c7e7e6c2aa86"> <state value="" 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<html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM 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Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pleckstrin homology-like domain, family A, member 3 HUGO:PHLDA3 HGNC:8934 ENTREZ:23612 UNIPROT:Q9Y5J5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PHLDA3"/> <bbox w="80.0" h="40.0" x="8765.001" y="1891.6742"/> </glyph> <glyph class="nucleic acid feature" id="s248_sa555" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="70.0" h="25.0" x="3837.3816" y="7298.367"/> </glyph> <glyph class="complex" id="s251_csa65" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO* Identifiers_end </body> </html> </notes> <label text="14-3-3:FOXO"/> <bbox w="97.25" h="120.0" x="8430.375" y="1633.0"/> <glyph class="macromolecule" id="s252_sa1009"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="8440.125" y="1643.5"/> <glyph class="state variable" id="_4ced6873-c7e6-4b23-8e63-099d69976d75"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8489.223" y="1638.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2420_sa1012"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 References_end </body> </html> </notes> <label text="FOXO*"/> <bbox w="80.0" h="40.0" x="8440.731" y="1695.3634"/> <glyph class="state variable" id="_c99c8ef3-4323-490d-9e0f-6249b34bcf23"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8489.92" y="1690.3634"/> </glyph> <glyph class="state variable" id="_80ea5c2f-d877-4bc0-be1a-1e70afca63ce"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8456.663" y="1690.3634"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s255_sa1286" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="4675.0" y="2795.0"/> <glyph class="state variable" id="_1b35b90d-01cf-448a-9119-2fbf94dcfbd0"> <state value="" variable="S98"/> <bbox w="25.0" h="10.0" x="4741.882" y="2830.0"/> </glyph> <glyph class="state variable" id="_7266b023-e215-4c40-8ca8-9d61ffd4ad79"> <state value="" variable="S69"/> <bbox w="25.0" h="10.0" x="4742.5" y="2790.0"/> </glyph> <glyph class="state variable" id="_baafbcf2-6335-4996-818e-110d6ac36d98"> 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Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="4877.3335" y="2793.6667"/> <glyph class="state variable" id="_014ca284-1288-4c5d-956d-66c8a46e25e0"> <state value="" variable="S98"/> <bbox w="25.0" h="10.0" x="4944.2153" y="2828.6667"/> </glyph> <glyph class="state variable" id="_1589816f-ebae-462d-89b3-38c29fefa164"> <state value="P" variable="S69"/> <bbox w="30.0" h="10.0" x="4942.3335" y="2788.6667"/> </glyph> <glyph class="state variable" id="_f6c8ab75-8fea-4076-8b12-432da5a0abbe"> <state value="" variable="S93"/> <bbox w="25.0" h="10.0" x="4864.8335" 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MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="5024.3335" y="2791.0"/> <glyph class="state variable" id="_a737f4a3-d9ae-49bf-aac9-31f124c9f8e3"> <state value="P" variable="S98"/> <bbox w="30.0" h="10.0" x="5088.7153" y="2826.0"/> </glyph> <glyph class="state variable" id="_64bbba6f-4452-4e9a-87bb-f5cff7da9fad"> <state value="P" variable="S69"/> <bbox w="30.0" h="10.0" x="5089.3335" y="2786.0"/> </glyph> <glyph class="state variable" 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text="BCL2L11:dynein motor complex"/> <bbox w="100.0" h="120.0" x="5155.5" y="3193.75"/> <glyph class="macromolecule" id="s1495_sa1298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dynein, light chain, LC8-type 1 HUGO:DYNLL1 HGNC:15476 ENTREZ:8655 UNIPROT:P63167 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: part of cytoskeletal structures with heavy and intermediary chains References_end </body> </html> </notes> <label text="DYNLL1"/> <bbox w="80.0" h="40.0" x="5164.5" y="3251.75"/> </glyph> <glyph class="macromolecule" id="s7609_sa1299"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="5164.5" y="3207.75"/> <glyph class="state variable" id="_bc5fde5c-366c-4313-a41c-5b311586c7fa"> <state value="P" variable="T56"/> <bbox w="30.0" h="10.0" x="5189.5317" y="3202.75"/> </glyph> <glyph class="state variable" id="_b1b78a5c-d9a9-4666-b451-44320625111f"> <state value="P" variable="S58"/> <bbox w="30.0" h="10.0" x="5229.5" y="3202.9648"/> </glyph> <glyph class="state variable" id="_e8e4a376-52c1-41d4-a31b-5f49df4130ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5216.2993" y="3242.75"/> </glyph> <glyph class="state variable" id="_85964493-639a-4399-9157-a82f26cf3f6c"> 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MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TNF"/> <bbox w="80.0" h="40.0" x="4620.0" y="130.0"/> </glyph> <glyph class="macromolecule" id="s289_sa1448" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end 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MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BID"/> <clone/> <bbox w="80.0" h="40.0" x="3347.5" y="2433.0"/> <glyph class="state variable" id="_d9d47bb4-63ff-4c65-a793-40cf0742e703"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3401.186" y="2428.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s289_sa4943" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BID"/> <clone/> <bbox w="80.0" h="40.0" x="9480.0" y="5810.0"/> <glyph class="state variable" id="_1750060f-9160-4bf6-b8c7-6d2ea96368a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9533.687" y="5805.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s290_sa1449" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <clone/> <bbox w="80.0" h="40.0" x="6860.0" y="2470.0"/> <glyph class="state variable" id="_291d8d70-fcce-4757-9e1e-66b4d9d0fbb0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6879.216" y="2505.0"/> </glyph> <glyph class="unit of information" id="_cd4404a7-3c11-44f2-a02d-8ed85ed00182"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6875.0" y="2465.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s290_sa3800" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <clone/> <bbox w="80.0" h="40.0" x="3197.5" y="2435.0"/> <glyph class="state variable" id="_dcc9fe2a-b712-4e50-909f-4fb2be008903"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3216.716" y="2470.0"/> </glyph> <glyph class="unit of information" id="_40504008-5c24-468e-a66c-ff8ebe63f592"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3212.5" y="2430.0"/> </glyph> </glyph> <glyph class="complex" id="s293_csa144" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BID:HSP90B1 Identifiers_end </body> </html> </notes> <label text="BID:HSP90B1"/> <bbox w="100.0" h="120.0" x="6469.928" y="2662.0566"/> <glyph class="macromolecule" id="s2543_sa1471"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BID"/> <bbox w="80.0" h="40.0" x="6480.428" y="2672.0566"/> <glyph class="state variable" id="_7e23ccb6-98cd-4c81-804f-dcccd81c8c13"> <state value="?" 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<head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1, alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="6469.0" y="2503.0"/> </glyph> <glyph class="macromolecule" id="s301_sa1459" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1, epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="6470.0" y="2550.0"/> </glyph> <glyph class="complex" id="s303_csa143" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK_beta_* Identifiers_end References_begin: casein kinase 2 References_end </body> </html> </notes> <label text="CSNK2"/> <bbox w="176.0" h="110.0" x="6404.0" y="2345.5"/> <glyph class="macromolecule" id="s4508_sa1460"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: casein kinase 2, alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="6413.0" y="2352.5"/> </glyph> <glyph class="macromolecule" id="s4509_sa1461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: casein kinase 2, alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="6495.0" y="2353.5"/> </glyph> <glyph class="macromolecule" id="s304_sa1462"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chemokine (C-C motif) ligand 19 HUGO:CCL19 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CKβ*"/> <bbox w="80.0" h="40.0" x="6413.0" y="2394.5"/> </glyph> <glyph class="macromolecule" id="s304_sa1463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chemokine (C-C motif) ligand 19 HUGO:CCL19 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CKβ*"/> <bbox w="80.0" h="40.0" x="6494.5" y="2395.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s307_sa1466" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:7857 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: N-myristoyltransferase 1 HUGO:NMT1 HGNC:7857 ENTREZ:4836 UNIPROT:P30419 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="NMT1"/> <bbox w="80.0" h="40.0" x="6970.0" y="2400.0"/> </glyph> <glyph class="macromolecule" id="s308_sa1467" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="7080.0" y="2470.0"/> <glyph class="state variable" id="_da34f0be-eca0-4f46-a363-9d450e990512"> <state value="My" variable=""/> <bbox w="20.0" h="10.0" x="7094.216" y="2505.0"/> </glyph> <glyph class="unit of information" id="_b307319e-0fec-4424-b011-6ec9b5875fed"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7095.0" y="2465.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s312_sa14" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 2, apoptosis-related cysteine peptidase HUGO:CASP2 HGNC:1503 ENTREZ:835 UNIPROT:P42575 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase2*"/> <clone/> <bbox w="80.0" h="40.0" x="6593.049" y="3405.8252"/> <glyph class="state variable" id="_2ada2575-8644-4a42-b5a3-cd76d5350bb7"> <state value="" variable="S122"/> <bbox w="30.0" h="10.0" x="6634.998" y="3400.8252"/> </glyph> </glyph> <glyph class="macromolecule" id="s312_sa4257" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 2, apoptosis-related cysteine peptidase HUGO:CASP2 HGNC:1503 ENTREZ:835 UNIPROT:P42575 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase2*"/> <clone/> <bbox w="80.0" h="40.0" x="3625.0" y="870.0"/> <glyph class="state variable" id="_dd62ce62-6a6e-4a1d-8d87-fd96e7001c77"> <state value="" variable="S122"/> <bbox w="30.0" h="10.0" x="3666.9492" y="865.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s313_sa16" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="7151.9487" y="4300.569"/> </glyph> <glyph class="macromolecule" id="s313_sa4116" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="1660.0" y="390.0"/> </glyph> <glyph class="macromolecule" id="s313_sa4255" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="3636.9485" y="800.5689"/> </glyph> <glyph class="macromolecule" id="s313_sa5064" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="8300.0" y="3840.0"/> </glyph> <glyph class="macromolecule" id="s314_sa15" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="6790.0" y="5400.0"/> <glyph class="state variable" id="_a6219671-8cfa-487d-8910-3bc22cf060e6"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="6798.595" y="5395.0"/> </glyph> <glyph class="state variable" id="_67b9cbed-e107-4884-bde4-389fc379f19b"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="6831.949" y="5395.0"/> </glyph> <glyph class="state variable" id="_edfc3fea-22a7-4c86-9f34-6b616647d0fb"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="6831.3306" y="5435.0"/> </glyph> <glyph class="state variable" id="_d5d48b46-c066-4863-9937-4a492b4323b7"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="6797.9756" y="5435.0"/> </glyph> <glyph class="state variable" id="_1869f119-23cb-4a54-a27b-14f61d02e8e4"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="6857.5" y="5415.0"/> </glyph> <glyph class="state variable" id="_a3e383f6-b9cd-4586-b4b3-8d17a5017f80"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6785.0" y="5415.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s314_sa4132" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="1448.0514" y="349.4311"/> <glyph class="state variable" id="_b3d9cd6f-90b6-45de-8444-358a498e7431"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="1456.6464" y="344.4311"/> </glyph> <glyph class="state variable" id="_08c7d820-5ee9-44be-9ce0-13d90caa4b9f"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="1490.0007" y="344.4311"/> </glyph> <glyph class="state variable" id="_e355df14-298a-4371-b810-c57793fafe80"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="1489.382" y="384.4311"/> </glyph> <glyph class="state variable" id="_e92a6f89-c505-4cb1-ac6e-c6f00ab57288"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="1456.0269" y="384.4311"/> </glyph> <glyph class="state variable" id="_b4235c57-bf2f-4fb5-a621-1d3a1442697f"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="1515.5514" y="364.4311"/> </glyph> <glyph class="state variable" id="_142fc8bf-fa81-4560-ae29-3dc1d504f80b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1443.0514" y="364.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s314_sa4176" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="3000.0" y="510.0"/> <glyph class="state variable" id="_6370fdbb-07bb-416f-afb2-75a3d25bce1e"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="3008.595" y="505.0"/> </glyph> <glyph class="state variable" id="_3f582ec8-76f4-4bdf-bf51-82e6f45be6b0"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="3041.9492" y="505.0"/> </glyph> <glyph class="state variable" id="_4bf22760-f2ee-4ca9-bf1e-e0e83ea19656"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="3041.3306" y="545.0"/> </glyph> <glyph class="state variable" id="_b96bc3e8-99d6-4f12-83e7-a9aa51d5c80e"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="3007.9756" y="545.0"/> </glyph> <glyph class="state variable" id="_f78ba0bb-1c53-4993-863d-b4edce9fb88e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="3067.5" y="525.0"/> </glyph> <glyph class="state variable" id="_15ecd480-afd8-4e85-b9cf-9bac2e6d2b8b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2995.0" y="525.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s314_sa4666" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="4978.0" y="6928.0"/> <glyph class="state variable" id="_b2cf5fcc-586d-4bd9-b393-cbfbacf045e2"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="4986.595" y="6923.0"/> </glyph> <glyph class="state variable" id="_050de461-cdc7-4d97-9375-35c41e6c43d3"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="5019.949" y="6923.0"/> </glyph> <glyph class="state variable" id="_98d61688-be6c-4802-8803-dc18829ef95c"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="5019.3306" y="6963.0"/> </glyph> <glyph class="state variable" id="_e6d72019-839f-4db3-a961-334f6099189c"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="4985.9756" y="6963.0"/> </glyph> <glyph class="state variable" id="_9493416f-2069-4128-b1dc-9c638324319b"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="5045.5" y="6943.0"/> </glyph> <glyph class="state variable" id="_9aada92d-dc8d-4e03-bf73-2039770455d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4973.0" y="6943.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s314_sa5066" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="8300.0" y="3900.0"/> <glyph class="state variable" id="_a8bbf998-35ac-4a46-b525-71dcdeb48b18"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="8308.595" y="3895.0"/> </glyph> <glyph class="state variable" id="_447a4561-55cd-40e1-a8c3-78c3294917bc"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="8341.949" y="3895.0"/> </glyph> <glyph class="state variable" id="_c41a7c1a-9946-436a-a469-b636df2ed7d4"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="8341.331" y="3935.0"/> </glyph> <glyph class="state variable" id="_bc5458ce-dffa-4463-9394-4ca292eaa88c"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="8307.976" y="3935.0"/> </glyph> <glyph class="state variable" id="_639876e8-1737-429f-92f4-9212a85f2cc4"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="8367.5" y="3915.0"/> </glyph> <glyph class="state variable" id="_db9cb7c2-0bab-43fe-82c4-e085a91691f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8295.0" y="3915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s318_sa798" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, liver HUGO:PFKL HGNC:8876 ENTREZ:5211 UNIPROT:P17858 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKL"/> <bbox w="80.0" h="40.0" x="1668.0" y="1090.1896"/> <glyph class="state variable" id="_9075ea7a-45eb-400a-86d1-f51c8a83462d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1723.381" y="1085.1896"/> </glyph> </glyph> <glyph class="macromolecule" id="s319_sa797" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, liver HUGO:PFKL HGNC:8876 ENTREZ:5211 UNIPROT:P17858 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKL"/> <bbox w="80.0" h="40.0" x="1534.0" y="1089.1896"/> <glyph class="state variable" id="_1cb78bb1-ffc3-430d-9513-52774080d20b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1586.881" y="1084.1896"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s330_sa1135" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 125b-1 HUGO:MIR125B1 HGNC:31506 ENTREZ:406911 Identifiers_end </body> </html> </notes> <label text="MIR125B1"/> <bbox w="90.0" h="25.0" x="6382.5" y="6640.0"/> <glyph class="unit of information" id="_a377f81e-c1e4-46cc-9fb2-8193a7380e38"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6412.5" y="6635.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s334_sa1787" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RAF1"/> <bbox w="80.0" h="40.0" x="4770.0" y="2470.0"/> </glyph> <glyph class="macromolecule" id="s338_sa976" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: runt-related transcription factor 3 HUGO:RUNX3 HGNC:10473 ENTREZ:864 UNIPROT:Q13761 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RUNX3"/> <bbox w="80.0" h="40.0" x="5082.5" y="7815.0"/> </glyph> <glyph class="complex" id="s340_csa233" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:PPP3CB:PPP3R1 Identifiers_end References_begin: PMID:7593193 over-expression plasmid DeltaCnA/CnB References_end </body> </html> </notes> <label text="calcineurin"/> <bbox w="100.0" h="120.0" x="2840.0" y="2960.0"/> <glyph class="macromolecule" id="s1457_sa1759"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="2850.0" y="2971.0"/> </glyph> <glyph class="macromolecule" id="s1458_sa1760"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PPP3R1"/> <bbox w="80.0" h="40.0" x="2850.0" y="3016.0"/> </glyph> <glyph class="simple chemical" id="s341_sa1761"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="2911.3538" y="3000.852"/> </glyph> </glyph> <glyph class="phenotype" id="s349_sa1" compartmentRef="c4_ca4"> <label text="Mitochondria outer~membrane integrity"/> <bbox w="141.94856" h="42.431103" x="4689.25" y="6162.569"/> </glyph> <glyph class="nucleic acid feature" id="s350_sa558" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BAD"/> <bbox w="70.0" h="25.0" x="3838.1555" y="7335.072"/> </glyph> <glyph class="nucleic acid feature" id="s351_sa560" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BAX"/> <bbox w="70.0" h="25.0" x="3917.3816" y="7298.367"/> </glyph> <glyph class="nucleic acid feature" id="s352_sa553" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BID"/> <bbox w="70.0" h="25.0" x="3756.1555" y="7329.558"/> </glyph> <glyph class="nucleic acid feature" id="s354_sa562" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:p21 synonym:CIP1 synonym:WAF1 References_end </body> </html> </notes> <label text="p21CIP1*"/> <bbox w="70.0" h="25.0" x="3911.7827" y="7337.7417"/> </glyph> <glyph class="nucleic acid feature" id="s357_sa984" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 182 HUGO:MIR182 HGNC:31553 ENTREZ:406958 Identifiers_end </body> </html> </notes> <label text="MIR182"/> <bbox w="90.0" h="25.0" x="5935.0" y="6663.5"/> <glyph class="unit of information" id="_f7e63129-a979-498a-94f1-2ae3e470dcdc"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5965.0" y="6658.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s384_sa660" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS 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CAS:604-98-8 Identifiers_end </body> </html> </notes> <label text="succinyl-CoA"/> <bbox w="70.0" h="25.0" x="642.75" y="5762.5"/> </glyph> <glyph class="simple chemical" id="s389_sa114" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15351 KEGGCOMPOUND:C00024 CAS:72-89-9 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis PMID:28645028 References_end </body> </html> </notes> <label text="acetyl-CoA"/> <bbox w="70.0" h="25.0" x="1518.9869" y="5788.5566"/> </glyph> <glyph class="macromolecule" id="s397_sa123" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lon peptidase 1, mitochondrial HUGO:LONP1 HGNC:9479 ENTREZ:9361 UNIPROT:P36776 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="LONP1"/> <bbox w="80.0" h="40.0" x="1520.0" y="6150.0"/> </glyph> <glyph class="source and sink" id="s398_sa119" compartmentRef="c5_ca5"> <label text="s398"/> <bbox w="30.0" h="30.0" x="1472.0" y="6107.0"/> </glyph> <glyph class="simple chemical" id="s405_sa131" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18009 KEGGCOMPOUND:C00006 CAS:53-59-8 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NADP+"/> <clone/> <bbox w="70.0" h="25.0" x="1115.75" y="5850.5"/> </glyph> <glyph class="simple chemical" id="s405_sa361" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18009 KEGGCOMPOUND:C00006 CAS:53-59-8 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NADP+"/> <clone/> <bbox w="70.0" h="25.0" x="2509.75" y="5563.0"/> </glyph> <glyph class="simple chemical" id="s405_sa1997" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18009 KEGGCOMPOUND:C00006 CAS:53-59-8 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NADP+"/> <clone/> <bbox w="70.0" h="25.0" x="1189.25" y="5582.5"/> </glyph> <glyph class="simple chemical" id="s406_sa136" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16474 KEGGCOMPOUND:C00005 CAS:53-57-6 Identifiers_end References_begin: ccharge:0 References_end </body> </html> </notes> <label text="NADPH"/> <clone/> <bbox w="70.0" h="25.0" x="981.75" y="5848.5"/> </glyph> <glyph class="simple chemical" id="s406_sa362" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16474 KEGGCOMPOUND:C00005 CAS:53-57-6 Identifiers_end References_begin: ccharge:0 References_end </body> </html> </notes> <label text="NADPH"/> <clone/> <bbox w="70.0" h="25.0" x="2511.75" y="5497.0"/> </glyph> <glyph class="simple chemical" id="s406_sa1995" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16474 KEGGCOMPOUND:C00005 CAS:53-57-6 Identifiers_end References_begin: ccharge:0 References_end </body> </html> </notes> <label text="NADPH"/> <clone/> <bbox w="70.0" h="25.0" x="1197.25" y="5640.5"/> </glyph> <glyph class="simple chemical" id="s409_sa146" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17552 KEGGCOMPOUND:C00035 Identifiers_end References_begin: 146-91-8 References_end </body> </html> </notes> <label text="GDP"/> <bbox w="70.0" h="25.0" x="572.75" y="5730.5"/> </glyph> <glyph class="simple chemical" id="s410_sa147" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end </body> </html> </notes> <label text="GTP"/> <bbox w="70.0" h="25.0" x="557.75" y="5611.5"/> </glyph> <glyph class="simple chemical" id="s411_sa211" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:32816 KEGGCOMPOUND:C00022 CAS:127-17-3 Identifiers_end </body> </html> </notes> <label text="pyruvate"/> <clone/> <bbox w="70.0" h="25.0" x="1856.7227" y="5789.056"/> </glyph> <glyph class="simple chemical" id="s411_sa2957" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:32816 KEGGCOMPOUND:C00022 CAS:127-17-3 Identifiers_end </body> </html> </notes> <label text="pyruvate"/> <clone/> <bbox w="70.0" h="25.0" x="965.0" y="6027.5"/> </glyph> <glyph class="simple chemical" id="s411_sa4286" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:32816 KEGGCOMPOUND:C00022 CAS:127-17-3 Identifiers_end </body> </html> </notes> <label text="pyruvate"/> <clone/> <bbox w="70.0" h="25.0" x="1109.25" y="5662.5"/> </glyph> <glyph class="simple chemical" id="s413_sa124" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27646922 ROS play a central role in cell signalling as well as in regulation of the main pathways ofapoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum (ER). 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References_end </body> </html> </notes> <label text="ROS"/> <clone/> <bbox w="70.0" h="25.0" x="1999.25" y="5742.5"/> </glyph> <glyph class="macromolecule" id="s427_sa1427" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) HUGO:NDUFS1 HGNC:7707 ENTREZ:4719 UNIPROT:P28331 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS1"/> <bbox w="80.0" h="40.0" x="845.0951" y="4535.387"/> <glyph class="state variable" id="_532a49d4-471c-4137-a632-e7430ae56cdc"> <state value="[2Fe-2S],[4Fe-4S],[4Fe-4S]" variable=""/> <bbox w="80.0" h="10.0" x="845.0951" y="4530.387"/> </glyph> </glyph> <glyph class="macromolecule" id="s432_sa283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa HUGO:NDUFV1 HGNC:7716 ENTREZ:4723 UNIPROT:P49821 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFV1"/> <bbox w="80.0" h="40.0" x="764.0951" y="4871.387"/> <glyph class="state variable" id="_07e3a1ca-3d81-43e2-bcae-a1e2ede544c2"> <state value="[4Fe-4S]" variable=""/> <bbox w="50.0" h="10.0" x="779.0951" y="4866.387"/> </glyph> </glyph> <glyph class="simple chemical" id="s2461_sa284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:17621 KEGGCOMPOUND:C00061 CAS:146-17-8 </body> </html> </notes> <label text="FMN"/> <bbox w="70.0" h="25.0" x="771.0951" y="4897.887"/> </glyph> <glyph class="macromolecule" id="s7590_sa285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) HUGO:NDUFS2 HGNC:7708 ENTREZ:4720 UNIPROT:O75306 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS2"/> <bbox w="80.0" h="40.0" x="764.0951" y="4788.387"/> </glyph> <glyph class="macromolecule" id="s7591_sa286"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa HUGO:NDUFV2 HGNC:7717 ENTREZ:4729 UNIPROT:P19404 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFV2"/> <bbox w="80.0" h="40.0" x="929.0951" y="4535.387"/> <glyph class="state variable" id="_527f1c6f-b550-4b8e-8c24-236b71311b98"> <state value="[2Fe-2S]" variable=""/> <bbox w="50.0" h="10.0" x="944.0951" y="4530.387"/> </glyph> </glyph> <glyph class="macromolecule" id="s440_sa287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) HUGO:NDUFS7 HGNC:7714 ENTREZ:374291 UNIPROT:O75251 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS7"/> <bbox w="80.0" h="40.0" x="845.0951" y="4664.387"/> <glyph class="state variable" id="_63e101bb-4e95-4ae0-9823-48634bee3135"> <state value="[4Fe-4S]" variable=""/> <bbox w="50.0" h="10.0" x="860.0951" y="4659.387"/> </glyph> </glyph> <glyph class="macromolecule" id="s7592_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) HUGO:NDUFS8 HGNC:7715 ENTREZ:4728 UNIPROT:O00217 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS8"/> <bbox w="80.0" h="40.0" x="931.0951" y="4748.387"/> <glyph class="state variable" id="_f4da4f36-3f5c-47e5-9f68-f9df02c607b8"> <state value="[4Fe-4S],[4Fe-4S]" variable=""/> <bbox w="80.0" h="10.0" x="931.0951" y="4743.387"/> </glyph> </glyph> <glyph class="macromolecule" id="s444_sa289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) HUGO:NDUFS3 HGNC:7710 ENTREZ:4722 UNIPROT:O75489 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS3"/> <bbox w="80.0" h="40.0" x="758.0951" y="4535.387"/> </glyph> <glyph class="macromolecule" id="s355_sa290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded NADH dehydrogenase 3 HUGO:MT-ND3 HGNC:7458 ENTREZ:4537 UNIPROT:P03897 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND3"/> <bbox w="80.0" h="40.0" x="933.0951" y="4830.387"/> </glyph> <glyph class="macromolecule" id="s446_sa291"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded NADH dehydrogenase 1 HUGO:MT-ND1 HGNC:7455 ENTREZ:4535 UNIPROT:P03886 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND1"/> <bbox w="80.0" h="40.0" x="764.0951" y="4828.387"/> </glyph> <glyph class="macromolecule" id="s448_sa292"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded NADH dehydrogenase 2 HUGO:MT-ND2 HGNC:7456 ENTREZ:4536 UNIPROT:P03891 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND2"/> <bbox w="80.0" h="40.0" x="1014.0951" y="4661.387"/> </glyph> <glyph class="macromolecule" id="s450_sa293"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded NADH dehydrogenase 4 HUGO:MT-ND4 HGNC:7459 ENTREZ:4538 UNIPROT:P03905 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND4"/> <bbox w="80.0" h="40.0" x="930.0951" y="4662.387"/> </glyph> <glyph class="macromolecule" id="s452_sa294"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded NADH dehydrogenase 5 HUGO:MT-ND5 HGNC:7461 ENTREZ:4540 UNIPROT:P03915 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND5"/> <bbox w="80.0" h="40.0" x="1097.0951" y="4662.387"/> </glyph> <glyph class="macromolecule" id="s360_sa295"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> HGNC:11998 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 6 HUGO:MT-ND6 HGNC:7462 ENTREZ:4541 UNIPROT:P03923 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND6"/> <bbox w="80.0" h="40.0" x="1097.0951" y="4746.387"/> </glyph> <glyph class="macromolecule" id="s361_sa296"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 HUGO:NDUFA13 HGNC:17194 ENTREZ:51079 UNIPROT:Q9P0J0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:GRIM19 References_end </body> </html> </notes> <label text="NDUFA13"/> <bbox w="80.0" h="40.0" x="846.0951" y="4622.387"/> </glyph> <glyph class="macromolecule" id="s367_sa297"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa HUGO:NDUFA11 HGNC:20371 ENTREZ:126328 UNIPROT:Q86Y39 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA11"/> <bbox w="80.0" h="40.0" x="759.0951" y="4663.387"/> </glyph> <glyph class="macromolecule" id="s368_sa298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa HUGO:NDUFA10 HGNC:7684 ENTREZ:4705 UNIPROT:O95299 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA10"/> <bbox w="80.0" h="40.0" x="1014.0951" y="4705.387"/> </glyph> <glyph class="macromolecule" id="s369_sa299"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa HUGO:NDUFA9 HGNC:7693 ENTREZ:4704 UNIPROT:Q16795 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA9"/> <bbox w="80.0" h="40.0" x="1097.0951" y="4535.387"/> </glyph> <glyph class="macromolecule" id="s7593_sa300"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) HUGO:NDUFS4 HGNC:7711 ENTREZ:4724 UNIPROT:O43181 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS4"/> <bbox w="80.0" h="40.0" x="759.0951" y="4578.387"/> </glyph> <glyph class="macromolecule" id="s454_sa301"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) HUGO:NDUFS5 HGNC:7712 ENTREZ:4725 UNIPROT:O43920 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS5"/> <bbox w="80.0" h="40.0" x="759.0951" y="4621.387"/> </glyph> <glyph class="macromolecule" id="s372_sa302"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) HUGO:NDUFS6 HGNC:7713 ENTREZ:4726 UNIPROT:O75380 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS6"/> <bbox w="80.0" h="40.0" x="929.0951" y="4577.387"/> </glyph> <glyph class="macromolecule" id="s7594_sa303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa HUGO:NDUFV3 HGNC:7719 ENTREZ:4731 UNIPROT:P56181 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFV3"/> <bbox w="80.0" h="40.0" x="1012.0951" y="4577.387"/> </glyph> <glyph class="macromolecule" id="s7595_sa304"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa HUGO:NDUFB2 HGNC:7697 ENTREZ:4708 UNIPROT:O95178 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB2"/> <bbox w="80.0" h="40.0" x="1097.0951" y="4619.387"/> </glyph> <glyph class="macromolecule" id="s375_sa305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HUGO:NDUFB8 HGNC:7703 ENTREZ:4714 UNIPROT:O95169 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB8"/> <bbox w="80.0" h="40.0" x="849.0951" y="4789.387"/> </glyph> <glyph class="macromolecule" id="s376_sa306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa HUGO:NDUFB11 HGNC:20372 ENTREZ:54539 UNIPROT:Q9NX14 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB11"/> <bbox w="80.0" h="40.0" x="1098.0951" y="4786.387"/> </glyph> <glyph class="macromolecule" id="s7596_sa307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa HUGO:NDUFC1 HGNC:7705 ENTREZ:4717 UNIPROT:O43677 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFC1"/> <bbox w="80.0" h="40.0" x="761.0951" y="4749.387"/> </glyph> <glyph class="macromolecule" id="s7597_sa308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa HUGO:NDUFA4 HGNC:7687 ENTREZ:4697 UNIPROT:O00483 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA4"/> <bbox w="80.0" h="40.0" x="1098.0951" y="4829.387"/> </glyph> <glyph class="macromolecule" id="s7598_sa309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa HUGO:NDUFB1 HGNC:7695 ENTREZ:4707 UNIPROT:O75438 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB1"/> <bbox w="80.0" h="40.0" x="848.0951" y="4871.387"/> </glyph> <glyph class="macromolecule" id="s7599_sa310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa HUGO:NDUFA1 HGNC:7683 ENTREZ:4694 UNIPROT:O15239 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA1"/> <bbox w="80.0" h="40.0" x="933.0951" y="4872.387"/> </glyph> <glyph class="macromolecule" id="s458_sa311"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa HUGO:NDUFB10 HGNC:7696 ENTREZ:4716 UNIPROT:O96000 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB10"/> <bbox w="80.0" h="40.0" x="1015.0951" y="4829.387"/> </glyph> <glyph class="macromolecule" id="s7600_sa312"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa HUGO:NDUFA8 HGNC:7692 ENTREZ:4702 UNIPROT:P51970 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA8"/> <bbox w="80.0" h="40.0" x="1098.0951" y="4872.387"/> </glyph> <glyph class="macromolecule" id="s462_sa313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa HUGO:NDUFAB1 HGNC:7694 ENTREZ:4706 UNIPROT:O14561 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFAB1"/> <bbox w="80.0" h="40.0" x="843.0951" y="4748.387"/> </glyph> <glyph class="macromolecule" id="s7601_sa314"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa HUGO:NDUFB5 HGNC:7700 ENTREZ:4711 UNIPROT:O43674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB5"/> <bbox w="80.0" h="40.0" x="1015.0951" y="4788.387"/> </glyph> <glyph class="macromolecule" id="s466_sa315"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa HUGO:NDUFB7 HGNC:7702 ENTREZ:4713 UNIPROT:P17568 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB7"/> <bbox w="80.0" h="40.0" x="931.0951" y="4705.387"/> </glyph> <glyph class="macromolecule" id="s468_sa316"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 HUGO:NDUFA12 HGNC:23987 ENTREZ:55967 UNIPROT:Q9UI09 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA12"/> <bbox w="80.0" h="40.0" x="1012.0951" y="4619.387"/> </glyph> <glyph class="macromolecule" id="s7602_sa317"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa HUGO:NDUFB6 HGNC:7701 ENTREZ:4712 UNIPROT:O95139 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB6"/> <bbox w="80.0" h="40.0" x="1015.0951" y="4748.387"/> </glyph> <glyph class="macromolecule" id="s7603_sa318"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa HUGO:NDUFB4 HGNC:7699 ENTREZ:4710 UNIPROT:O95168 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB4"/> <bbox w="80.0" h="40.0" x="760.0951" y="4706.387"/> </glyph> <glyph class="macromolecule" id="s7604_sa319"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> from Uniprot:"homodimer, by similarity" ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa HUGO:NDUFA7 HGNC:7691 ENTREZ:4701 UNIPROT:O95182 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA7"/> <bbox w="80.0" h="40.0" x="845.0951" y="4706.387"/> </glyph> <glyph class="macromolecule" id="s429_sa320"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa HUGO:NDUFC2 HGNC:7706 ENTREZ:4718 UNIPROT:O95298 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFC2"/> <bbox w="80.0" h="40.0" x="932.0951" y="4788.387"/> </glyph> <glyph class="macromolecule" id="s430_sa321"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa HUGO:NDUFA6 HGNC:7690 ENTREZ:4700 UNIPROT:P56556 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA6"/> <bbox w="80.0" h="40.0" x="1013.0951" y="4535.387"/> </glyph> <glyph class="macromolecule" id="s470_sa322"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa HUGO:NDUFA5 HGNC:7688 ENTREZ:4698 UNIPROT:Q16718 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA5"/> <bbox w="80.0" h="40.0" x="1096.0951" y="4577.387"/> </glyph> <glyph class="macromolecule" id="s472_sa323"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa HUGO:NDUFB3 HGNC:7698 ENTREZ:4709 UNIPROT:O43676 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB3"/> <bbox w="80.0" h="40.0" x="1097.0951" y="4704.387"/> </glyph> <glyph class="macromolecule" id="s474_sa324"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa HUGO:NDUFA3 HGNC:7686 ENTREZ:4696 UNIPROT:O95167 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA3"/> <bbox w="80.0" h="40.0" x="930.0951" y="4620.387"/> </glyph> <glyph class="macromolecule" id="s476_sa325"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa HUGO:NDUFA2 HGNC:7685 ENTREZ:4695 UNIPROT:O43678 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFA2"/> <bbox w="80.0" h="40.0" x="847.0951" y="4829.387"/> </glyph> <glyph class="macromolecule" id="s7605_sa326"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded NADH dehydrogenase 4L HUGO:MT-ND4L HGNC:7460 ENTREZ:4539 UNIPROT:P03901 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND4L"/> <bbox w="80.0" h="40.0" x="846.0951" y="4577.387"/> </glyph> <glyph class="macromolecule" id="s7606_sa327"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa HUGO:NDUFB9 HGNC:7704 ENTREZ:4715 UNIPROT:Q9Y6M9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFB9"/> <bbox w="80.0" h="40.0" x="1015.5951" y="4872.887"/> </glyph> </glyph> <glyph class="macromolecule" id="s491_sa278" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) HUGO:GZMA HGNC:4708 ENTREZ:3001 UNIPROT:P12544 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GZMA"/> <bbox w="80.0" h="40.0" x="207.5" y="4346.0"/> </glyph> <glyph class="simple chemical" id="s493_sa2533" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28494 KEGGCOMPOUND:C05980 Identifiers_end </body> </html> </notes> <label text="cardiolipin"/> <bbox w="70.0" h="25.0" x="3378.75" y="4513.5"/> </glyph> <glyph class="macromolecule" id="s494_sa2538" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: holocytochrome c synthase HUGO:HCCS HGNC:4837 ENTREZ:3052 UNIPROT:P53701 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="HCCS"/> <bbox w="80.0" h="40.0" x="3206.75" y="4480.0"/> </glyph> <glyph class="simple chemical" id="s524_sa348" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="1779.25" y="5552.5"/> </glyph> <glyph class="simple chemical" id="s524_sa2174" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="2309.25" y="5392.5"/> </glyph> <glyph class="source and sink" id="s541_sa261" compartmentRef="c4_ca4"> <label text="s541"/> <bbox w="30.0" h="30.0" x="627.465" y="5048.6724"/> </glyph> <glyph class="complex" id="s557_csa30" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytochrome_C*:cardiolipin Identifiers_end </body> </html> </notes> <label text="ferriCYCS"/> <bbox w="100.0" h="120.0" x="1628.75" y="5054.33"/> <glyph class="simple chemical" id="s1924_sa404"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:28494 KEGGCOMPOUND:C05980 </body> </html> </notes> <label text="cardiolipin"/> <bbox w="70.0" h="25.0" x="1643.75" y="5115.33"/> </glyph> <glyph class="macromolecule" id="s3474_sa2248"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="1638.75" y="5068.0"/> <glyph class="state variable" id="_242e6788-4b58-4584-993f-ef7a87e871bf"> <state value="ferriheme" variable=""/> <bbox w="55.0" h="10.0" x="1651.25" y="5063.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s567_csa237" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:GCK:PPP1C*:PRKAC*:WASF1 Identifiers_end </body> </html> </notes> <label text="BAD:WASF1:GCK:PRKAC:PPP1C"/> <bbox w="180.0" h="168.0" x="4060.0" y="3856.0"/> <glyph class="macromolecule" id="s45_sa1782"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: WAS protein family, member 1 HUGO:WASF1 HGNC:12732 ENTREZ:8936 UNIPROT:Q92558 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="WASF1"/> <bbox w="80.0" h="40.0" x="4068.0" y="3956.0"/> </glyph> <glyph class="macromolecule" id="s3170_sa1783"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glucokinase (hexokinase 4) HUGO:GCK HGNC:4195 ENTREZ:2645 UNIPROT:P35557 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GCK"/> <bbox w="80.0" h="40.0" x="4066.0" y="3864.0"/> </glyph> <glyph class="macromolecule" id="s3172_sa1784"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="4068.0" y="3912.0"/> <glyph class="state variable" id="_243f6eb6-7b07-4ca8-9274-9edf64b0eaac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4086.595" y="3907.0"/> </glyph> <glyph class="state variable" id="_7632d955-8cc4-4392-aeaa-947061c5213f"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="4109.949" y="3907.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s48_sa1785"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 1, catalytic subunit, alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 protein phosphatase 1, catalytic subunit, beta isozyme HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 protein phosphatase 1, catalytic subunit, gamma isozyme HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: catalytic subunit of phosphatase PP1A, PP1c 3 genes encode 3 isoforms References_end </body> </html> </notes> <label text="PPP1C*"/> <bbox w="80.0" h="40.0" x="4152.0" y="3912.0"/> </glyph> <glyph class="macromolecule" id="s3162_sa1786"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: There are 3 different genes that code for PKA catalytic subunits References_end </body> </html> </notes> <label text="PRKAC*"/> <bbox w="80.0" h="40.0" x="4152.0" y="3864.0"/> </glyph> </glyph> <glyph class="complex" id="s577_csa13" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DLD:DLST:FAD:OGDH Identifiers_end References_begin: stoichiometry:FALSE References_end </body> </html> </notes> <label text="2-oxoglutarate dehydrogenase"/> <bbox w="272.0" h="94.0" x="540.75" y="5894.0"/> <glyph class="macromolecule" id="s578_sa179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="703.0" y="5898.75"/> </glyph> <glyph class="simple chemical" id="s579_sa180"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="709.0" y="5923.25"/> </glyph> <glyph class="macromolecule" id="s578_sa181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="713.0" y="5908.75"/> </glyph> <glyph class="simple chemical" id="s579_sa182"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="719.0" y="5933.25"/> </glyph> <glyph class="macromolecule" id="s578_sa183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="723.0" y="5918.75"/> </glyph> <glyph class="simple chemical" id="s579_sa184"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="729.0" y="5943.25"/> </glyph> <glyph class="macromolecule" id="s580_sa185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) HUGO:OGDH HGNC:8124 ENTREZ:4967 UNIPROT:Q02218 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="OGDH"/> <bbox w="80.0" h="40.0" x="623.75" y="5897.0"/> </glyph> <glyph class="macromolecule" id="s580_sa186"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) HUGO:OGDH HGNC:8124 ENTREZ:4967 UNIPROT:Q02218 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="OGDH"/> <bbox w="80.0" h="40.0" x="633.75" y="5907.0"/> </glyph> <glyph class="macromolecule" id="s580_sa187"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) HUGO:OGDH HGNC:8124 ENTREZ:4967 UNIPROT:Q02218 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="OGDH"/> <bbox w="80.0" h="40.0" x="643.75" y="5917.0"/> </glyph> <glyph class="macromolecule" id="s581_sa188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) HUGO:DLST HGNC:2911 ENTREZ:1743 UNIPROT:P36957 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="DLST"/> <bbox w="80.0" h="40.0" x="545.75" y="5897.0"/> </glyph> <glyph class="macromolecule" id="s581_sa189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) HUGO:DLST HGNC:2911 ENTREZ:1743 UNIPROT:P36957 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="DLST"/> <bbox w="80.0" h="40.0" x="555.75" y="5907.0"/> </glyph> <glyph class="macromolecule" id="s581_sa190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) HUGO:DLST HGNC:2911 ENTREZ:1743 UNIPROT:P36957 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="DLST"/> <bbox w="80.0" h="40.0" x="565.75" y="5917.0"/> </glyph> </glyph> <glyph class="complex" id="s584_csa14" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SUCLG1:SUCLG2 Identifiers_end </body> </html> </notes> <label text="succinyl coA synthetase"/> <bbox w="100.0" h="120.0" x="432.75" y="5623.0"/> <glyph class="macromolecule" id="s582_sa191"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate-CoA ligase, alpha subunit HUGO:SUCLG1 HGNC:11449 ENTREZ:8802 UNIPROT:P53597 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SUCLG1"/> <bbox w="80.0" h="40.0" x="442.75" y="5635.0"/> </glyph> <glyph class="macromolecule" id="s583_sa192"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate-CoA ligase, GDP-forming, beta subunit HUGO:SUCLG2 HGNC:11450 ENTREZ:8801 UNIPROT:Q96I99 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SUCLG2"/> <bbox w="80.0" h="40.0" x="442.75" y="5679.0"/> </glyph> </glyph> <glyph class="complex" id="s646_csa20" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAD:SDHA:SDHB:SDHC:SDHD:cardiolipin:heme b:phosphatidylethanolamine Identifiers_end References_begin: synonym:complex II synonym:1.3.5.1 synonym:fumarate reductase References_end </body> </html> </notes> <label text="succinate dehydrogenase"/> <bbox w="230.0" h="214.0" x="929.25" y="4958.0"/> <glyph class="macromolecule" id="s402_sa264"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate dehydrogenase complex, subunit B, iron sulfur (Ip) HUGO:SDHB HGNC:10681 ENTREZ:6390 UNIPROT:P21912 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: iron-sulfur protein References_end </body> </html> </notes> <label text="SDHB"/> <bbox w="80.0" h="40.0" x="955.25" y="5068.0"/> <glyph class="state variable" id="_3cca361f-e5ea-4555-a4f8-c37e200c7404"> <state value="[2Fe-2S],[4Fe-4S],[3Fe-4S]" variable=""/> <bbox w="80.0" h="10.0" x="955.25" y="5063.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7607_sa265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa HUGO:SDHC HGNC:10682 ENTREZ:6391 UNIPROT:Q99643 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: mono-heme cytochrome b References_end </body> </html> </notes> <label text="SDHC"/> <bbox w="80.0" h="40.0" x="1065.25" y="4985.0"/> </glyph> <glyph class="macromolecule" id="s535_sa266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate dehydrogenase complex, subunit D, integral membrane protein HUGO:SDHD HGNC:10683 ENTREZ:6392 UNIPROT:O14521 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: cytochrome b560 References_end </body> </html> </notes> <label text="SDHD"/> <bbox w="80.0" h="40.0" x="1065.25" y="5054.0"/> </glyph> <glyph class="simple chemical" id="s2462_sa267"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:26355 KEGGCOMPOUND:C00032 CAS:14875-96-8 </body> </html> </notes> <label text="heme b"/> <bbox w="70.0" h="25.0" x="1072.25" y="5018.5"/> </glyph> <glyph class="simple chemical" id="s537_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:28494 KEGGCCOMPOUND:C05980 </body> </html> </notes> <label text="cardiolipin"/> <bbox w="70.0" h="25.0" x="1052.25" y="5091.5"/> </glyph> <glyph class="simple chemical" id="s540_sa269"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16038 KEGGCOMPOUND:C00350 </body> </html> </notes> <label text="phosphatidylethanolamine"/> <bbox w="198.0" h="30.5" x="955.25" y="5119.75"/> </glyph> <glyph class="macromolecule" id="s93_sa270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate dehydrogenase complex, subunit A, flavoprotein (Fp) HUGO:SDHA HGNC:10680 ENTREZ:6389 UNIPROT:P31040 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: FAD cofactor binding References_end </body> </html> </notes> <label text="SDHA"/> <bbox w="80.0" h="40.0" x="959.25" y="4983.0"/> </glyph> <glyph class="simple chemical" id="s92_sa271"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="962.25" y="5016.5"/> </glyph> </glyph> <glyph class="complex" id="s661_csa29" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CYC1:MT-CYB:UCRC*:UQCRB:UQCRC1:UQCRC11:UQCRC2:UQCRFS1:UQCRH:UQCRQ:cleaved~UQCRFS1* Identifiers_end References_begin: composition of complex III from uniprot References_end </body> </html> </notes> <label text="ubiquinol-cytochrome c reductase"/> <bbox w="342.0" h="154.0" x="1261.75" y="4934.33"/> <glyph class="macromolecule" id="s648_sa393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome b HUGO:MT-CYB HGNC:7427 ENTREZ:4519 UNIPROT:P00156 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CYB"/> <bbox w="80.0" h="40.0" x="1267.75" y="5022.33"/> </glyph> <glyph class="macromolecule" id="s649_sa394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c-1 HUGO:CYC1 HGNC:2579 ENTREZ:1537 UNIPROT:P08574 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="CYC1"/> <bbox w="80.0" h="40.0" x="1347.75" y="4938.33"/> </glyph> <glyph class="macromolecule" id="s662_sa395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 HUGO:UQCRFS1 HGNC:12587 ENTREZ:7386 UNIPROT:P47985 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRFS1"/> <bbox w="80.0" h="40.0" x="1347.75" y="4980.33"/> <glyph class="state variable" id="_12a5a12d-b2de-4aa2-bd0b-79977caf10b8"> <state value="2Fe-2S" variable=""/> <bbox w="40.0" h="10.0" x="1367.75" y="4975.33"/> </glyph> </glyph> <glyph class="macromolecule" id="s651_sa396"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase core protein I HUGO:UQCRC1 HGNC:12585 ENTREZ:7384 UNIPROT:P31930 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRC1"/> <bbox w="80.0" h="40.0" x="1265.75" y="4938.33"/> </glyph> <glyph class="macromolecule" id="s652_sa397"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase core protein II HUGO:UQCRC2 HGNC:12586 ENTREZ:7385 UNIPROT:P22695 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRC2"/> <bbox w="80.0" h="40.0" x="1265.75" y="4980.33"/> </glyph> <glyph class="macromolecule" id="s653_sa398"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase hinge protein HUGO:UQCRH HGNC:12590 ENTREZ:7388 UNIPROT:P07919 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRH"/> <bbox w="80.0" h="40.0" x="1349.75" y="5022.33"/> </glyph> <glyph class="macromolecule" id="s654_sa399"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase binding protein HUGO:UQCRB HGNC:12582 ENTREZ:7381 UNIPROT:P14927 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRB"/> <bbox w="80.0" h="40.0" x="1429.75" y="4938.33"/> </glyph> <glyph class="macromolecule" id="s655_sa400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa HUGO:UQCRQ HGNC:29594 ENTREZ:27089 UNIPROT:O14949 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRQ"/> <bbox w="80.0" h="40.0" x="1429.75" y="4980.33"/> </glyph> <glyph class="macromolecule" id="s656_sa401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase, complex III subunit XI HUGO:UQCR11 HGNC:30862 ENTREZ:10975 UNIPROT:O14957 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRC11"/> <bbox w="80.0" h="40.0" x="1513.75" y="4938.33"/> </glyph> <glyph class="macromolecule" id="s660_sa403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase, complex III subunit X HUGO:UQCR10 HGNC:30863 ENTREZ:29796 UNIPROT:Q9UDW1 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UCRC*"/> <bbox w="80.0" h="40.0" x="1429.75" y="5022.33"/> </glyph> <glyph class="macromolecule" id="s3467_sa480"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 HUGO:UQCRFS1 HGNC:12587 ENTREZ:7386 UNIPROT:P47985 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="cleaved~UQCRFS1*"/> <bbox w="80.0" h="40.0" x="1512.75" y="4981.0"/> <glyph class="unit of information" id="_905af272-c183-4dbf-8e72-f3d4b79dde25"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1527.75" y="4976.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s705_csa298" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G*:ATP5H:ATP5I:ATP5J:ATP5J2:ATP5L:ATP5O:ATP5S:MT-ATP6:MT-ATP8 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: stoichiometry:FALSE PMID:12110673 purification of human mitochondrial ATP synthase PMID:11744738 ATP5SL References_end </body> </html> </notes> <label text="ATP synthase"/> <bbox w="331.0" h="197.0" x="2793.75" y="4693.5"/> <glyph class="macromolecule" id="s708_sa2544"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded ATP synthase 6 HUGO:MT-ATP6 HGNC:7414 ENTREZ:4508 UNIPROT:P00846 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ATP6"/> <bbox w="80.0" h="40.0" x="2875.75" y="4781.5"/> </glyph> <glyph class="macromolecule" id="s709_sa2545"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded ATP synthase 8 HUGO:MT-ATP8 HGNC:7415 ENTREZ:4509 UNIPROT:P03928 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ATP8"/> <bbox w="80.0" h="40.0" x="2876.75" y="4823.5"/> </glyph> <glyph class="macromolecule" id="s710_sa2546"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle HUGO:ATP5A1 HGNC:823 ENTREZ:498 UNIPROT:P25705 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5A1"/> <bbox w="80.0" h="40.0" x="2793.75" y="4697.5"/> </glyph> <glyph class="macromolecule" id="s711_sa2547"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide HUGO:ATP5B HGNC:830 ENTREZ:506 UNIPROT:P06576 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5B"/> <bbox w="80.0" h="40.0" x="2795.75" y="4739.5"/> </glyph> <glyph class="macromolecule" id="s712_sa2548"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 HUGO:ATP5C1 HGNC:833 ENTREZ:509 UNIPROT:P36542 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5C1"/> <bbox w="80.0" h="40.0" x="2795.75" y="4781.5"/> </glyph> <glyph class="macromolecule" id="s713_sa2549"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit HUGO:ATP5D HGNC:837 ENTREZ:513 UNIPROT:P30049 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5D"/> <bbox w="80.0" h="40.0" x="2794.75" y="4823.5"/> </glyph> <glyph class="macromolecule" id="s714_sa2550"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit HUGO:ATP5E HGNC:838 ENTREZ:514 UNIPROT:P56381 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5E"/> <bbox w="80.0" h="40.0" x="2877.75" y="4697.5"/> </glyph> <glyph class="macromolecule" id="s715_sa2551"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit HUGO:ATP5O HGNC:850 ENTREZ:539 UNIPROT:P48047 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5O"/> <bbox w="80.0" h="40.0" x="2875.75" y="4739.5"/> </glyph> <glyph class="macromolecule" id="s716_sa2552"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 HUGO:ATP5F1 HGNC:840 ENTREZ:515 UNIPROT:P24539 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5F1"/> <bbox w="80.0" h="40.0" x="2957.75" y="4697.5"/> </glyph> <glyph class="macromolecule" id="s717_sa2553"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) HUGO:ATP5G1 HGNC:841 ENTREZ:516 UNIPROT:P05496 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) HUGO:ATP5G2 HGNC:842 ENTREZ:517 UNIPROT:Q06055 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) HUGO:ATP5G3 HGNC:843 ENTREZ:518 UNIPROT:P48201 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5G*"/> <bbox w="80.0" h="40.0" x="2957.75" y="4739.5"/> </glyph> <glyph class="macromolecule" id="s718_sa2554"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d HUGO:ATP5H HGNC:845 ENTREZ:10476 UNIPROT:O75947 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5H"/> <bbox w="80.0" h="40.0" x="2957.75" y="4781.5"/> </glyph> <glyph class="macromolecule" id="s719_sa2555"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E HUGO:ATP5I HGNC:846 ENTREZ:521 UNIPROT:P56385 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5I"/> <bbox w="80.0" h="40.0" x="2958.75" y="4823.5"/> </glyph> <glyph class="macromolecule" id="s720_sa2556"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 HUGO:ATP5J HGNC:847 ENTREZ:522 UNIPROT:P18859 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5J"/> <bbox w="80.0" h="40.0" x="3039.75" y="4697.5"/> </glyph> <glyph class="macromolecule" id="s721_sa2557"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 HUGO:ATP5J2 HGNC:848 ENTREZ:9551 UNIPROT:P56134 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5J2"/> <bbox w="80.0" h="40.0" x="3040.75" y="4737.5"/> </glyph> <glyph class="macromolecule" id="s722_sa2558"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G HUGO:ATP5L HGNC:14247 ENTREZ:10632 UNIPROT:O75964 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5L"/> <bbox w="80.0" h="40.0" x="3040.75" y="4779.5"/> </glyph> <glyph class="macromolecule" id="s7615_sa2559"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) HUGO:ATP5S HGNC:18799 ENTREZ:27109 UNIPROT:Q99766 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5S"/> <bbox w="80.0" h="40.0" x="3040.75" y="4821.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s724_sa2516" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase mitochondrial F1 complex assembly factor 1 HUGO:ATPAF1 HGNC:18803 ENTREZ:64756 UNIPROT:Q5TC12 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATPAF1"/> <bbox w="80.0" h="40.0" x="2726.75" y="4925.0"/> </glyph> <glyph class="macromolecule" id="s725_sa2513" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase mitochondrial F1 complex assembly factor 2 HUGO:ATPAF2 HGNC:18802 ENTREZ:91647 UNIPROT:Q8N5M1 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATPAF2"/> <bbox w="80.0" h="40.0" x="2640.75" y="4913.0"/> </glyph> <glyph class="source and sink" id="s726_sa2515" compartmentRef="c4_ca4"> <label text="s726"/> <bbox w="30.0" h="30.0" x="2574.75" y="4827.0"/> </glyph> <glyph class="macromolecule" id="s727_sa2514" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transmembrane protein 70 HUGO:TMEM70 HGNC:26050 ENTREZ:54968 UNIPROT:Q9BUB7 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="TMEM70"/> <bbox w="80.0" h="40.0" x="2587.75" y="4859.0"/> </glyph> <glyph class="macromolecule" id="s730_sa2526" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: uncoupling protein 1 (mitochondrial, proton carrier) HUGO:UCP1 HGNC:12517 ENTREZ:7350 UNIPROT:P25874 uncoupling protein 2 (mitochondrial, proton carrier) HUGO:UCP2 HGNC:12518 ENTREZ:7351 UNIPROT:P55851 uncoupling protein 3 (mitochondrial, proton carrier) HUGO:UCP3 HGNC:12519 ENTREZ:7352 UNIPROT:P55916 solute carrier family 25, member 27 HUGO:SLC25A27 HGNC:21065 ENTREZ:9481 UNIPROT:O95847 solute carrier family 25 (mitochondrial carrier, brain), member 14 HUGO:SLC25A14 HGNC:10984 ENTREZ:9016 UNIPROT:O95258 solute carrier family 25, member 47 HUGO:SLC25A47 HGNC:20115 ENTREZ:283600 UNIPROT:Q6Q0C1 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym: UCP4 synonym: UCP5 synonym: HDMCP References_end </body> </html> </notes> <label text="UCP*"/> <bbox w="80.0" h="40.0" x="3573.75" y="4792.0"/> </glyph> <glyph class="macromolecule" id="s765_sa2521" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase inhibitory factor 1 HUGO:ATPIF1 HGNC:871 ENTREZ:93974 UNIPROT:Q9UII2 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATPIF1"/> <bbox w="80.0" h="40.0" x="3550.0" y="4910.0"/> </glyph> <glyph class="macromolecule" id="s804_sa472" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: surfeit 1 HUGO:SURF1 HGNC:11474 ENTREZ:6834 UNIPROT:Q15526 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: PMID:10556303 in simian COS7 cells,transiently expressed Flag-tagged human SURF1 resides at the inner membrane of mitochondria References_end </body> </html> </notes> <label text="SURF1"/> <bbox w="80.0" h="40.0" x="2256.75" y="4865.0"/> </glyph> <glyph class="source and sink" id="s821_sa475" compartmentRef="c4_ca4"> <label text="s821"/> <bbox w="30.0" h="30.0" x="2151.75" y="4970.0"/> </glyph> <glyph class="complex" id="s840_csa19" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAD:SDHA Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHA"/> <bbox w="94.0" h="84.0" x="781.25" y="5183.375"/> <glyph class="macromolecule" id="s531_sa262"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: succinate dehydrogenase complex, subunit A, flavoprotein (Fp) HUGO:SDHA HGNC:10680 ENTREZ:6389 UNIPROT:P31040 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: FAD cofactor binding References_end </body> </html> </notes> <label text="SDHA"/> <bbox w="80.0" h="40.0" x="787.25" y="5187.375"/> </glyph> <glyph class="simple chemical" id="s533_sa263"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="790.25" y="5220.875"/> </glyph> </glyph> <glyph class="simple chemical" id="s843_sa258" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 Identifiers_end </body> </html> </notes> <label text="FAD"/> <clone/> <bbox w="70.0" h="25.0" x="959.25" y="5242.5"/> </glyph> <glyph class="simple chemical" id="s843_sa1953" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 Identifiers_end </body> </html> </notes> <label text="FAD"/> <clone/> <bbox w="70.0" h="25.0" x="1292.75" y="4508.0"/> </glyph> <glyph class="macromolecule" id="s844_sa259" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit A, flavoprotein (Fp) HUGO:SDHA HGNC:10680 ENTREZ:6389 UNIPROT:P31040 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: FAD cofactor binding References_end </body> </html> </notes> <label text="SDHA"/> <bbox w="80.0" h="40.0" x="956.25" y="5193.625"/> </glyph> <glyph class="macromolecule" id="s845_sa257" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex assembly factor 2 HUGO:SDHAF2 HGNC:26034 ENTREZ:54949 UNIPROT:Q9NX18 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:SDH5 References_end </body> </html> </notes> <label text="SDHAF2"/> <bbox w="80.0" h="40.0" x="844.25" y="5405.0"/> </glyph> <glyph class="simple chemical" id="s862_sa1145" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15741 Identifiers_end </body> </html> </notes> <label text="succinate"/> <bbox w="70.0" h="25.0" x="435.0" y="4287.5"/> </glyph> <glyph class="macromolecule" id="s863_sa1143" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 HUGO:SLC25A10 HGNC:10980 ENTREZ:1468 UNIPROT:Q9UBX3 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC25A10"/> <bbox w="80.0" h="40.0" x="584.0997" y="4940.0"/> </glyph> <glyph class="macromolecule" id="s864_sa1142" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 HUGO:SLC25A11 HGNC:10981 ENTREZ:8402 UNIPROT:Q02978 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC25A11"/> <clone/> <bbox w="80.0" h="40.0" x="584.0997" y="4984.0"/> </glyph> <glyph class="macromolecule" id="s864_sa1972" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 HUGO:SLC25A11 HGNC:10981 ENTREZ:8402 UNIPROT:Q02978 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC25A11"/> <clone/> <bbox w="80.0" h="40.0" x="454.25" y="5225.0"/> </glyph> <glyph class="macromolecule" id="s889_sa474" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SCO1 cytochrome c oxidase assembly protein HUGO:SCO1 HGNC:10603 ENTREZ:6341 UNIPROT:O75880 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SCO1"/> <bbox w="80.0" h="40.0" x="2273.75" y="4952.5234"/> </glyph> <glyph class="macromolecule" id="s890_sa471" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase assembly homolog 17 (yeast) HUGO:COX17 HGNC:2264 ENTREZ:10063 UNIPROT:Q14061 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX17"/> <bbox w="80.0" h="40.0" x="2480.75" y="4950.5234"/> </glyph> <glyph class="macromolecule" id="s892_sa2532" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase assembly homolog 15 (yeast) HUGO:COX15 HGNC:2263 ENTREZ:1355 UNIPROT:Q7KZN9 Identifiers_end Maps_Modules_begin: MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="COX15"/> <bbox w="80.0" h="40.0" x="4096.25" y="5416.0"/> </glyph> <glyph class="simple chemical" id="s893_sa2536" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:24479 KEGGCOMPOUND:C15670 CAS:18535-39-2 Identifiers_end </body> </html> </notes> <label text="heme a"/> <bbox w="70.0" h="25.0" x="1294.3218" y="3922.8557"/> </glyph> <glyph class="simple chemical" id="s894_sa2537" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:24480 KEGGCOMPOUND:C15672 CAS:137397-56-9 Identifiers_end </body> </html> </notes> <label text="heme o"/> <bbox w="70.0" h="25.0" x="1416.3218" y="3921.3557"/> </glyph> <glyph class="simple chemical" id="s896_sa2541" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:50277 KEGGCOMPOUND:C00448 CAS:13058-04-3 Identifiers_end </body> </html> </notes> <label text="farnesyl diphosphate"/> <bbox w="152.5" h="28.5" x="1454.25" y="3858.5"/> </glyph> <glyph class="macromolecule" id="s897_sa2539" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase assembly homolog 10 (yeast) HUGO:COX10 HGNC:2260 ENTREZ:1352 UNIPROT:Q12887 Identifiers_end Maps_Modules_begin: MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="COX10"/> <bbox w="80.0" h="40.0" x="4096.25" y="5336.0"/> </glyph> <glyph class="macromolecule" id="s898_sa476" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome c oxidase I HUGO:MT-CO1 HGNC:7419 ENTREZ:4512 UNIPROT:P00395 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO1"/> <bbox w="80.0" h="40.0" x="2356.75" y="4805.0"/> </glyph> <glyph class="nucleic acid feature" id="s899_sa2728" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome c oxidase I HUGO:MT-CO1 HGNC:7419 ENTREZ:4512 UNIPROT:P00395 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO1"/> <bbox w="90.0" h="25.0" x="2921.0" y="6117.5"/> <glyph class="unit of information" id="_789aac10-b836-4250-9bd8-e1367cc9362e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2956.0" y="6112.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s900_sa477" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: translational activator of mitochondrially encoded cytochrome c oxidase I HUGO:TACO1 HGNC:24316 ENTREZ:51204 UNIPROT:Q9BSH4 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TACO1"/> <bbox w="80.0" h="40.0" x="2594.25" y="5865.0"/> </glyph> <glyph class="macromolecule" id="s933_sa1889" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA fragmentation factor, 45kDa, alpha polypeptide HUGO:DFFA HGNC:2772 ENTREZ:1676 UNIPROT:O00273 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:ICAD References_end </body> </html> </notes> <label text="DFFA"/> <bbox w="80.0" h="40.0" x="1052.0" y="6624.0"/> </glyph> <glyph class="complex" id="s934_csa35" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase9* Identifiers_end </body> </html> </notes> <label text="redox_CASP9:CASP9"/> <bbox w="100.0" h="140.0" x="3650.0" y="4170.0"/> <glyph class="macromolecule" id="s935_sa497"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="3658.0" y="4184.0"/> <glyph class="state variable" id="_63855e36-7cad-4eb3-a297-de036ddeeb84"> <state value="-S-S-" variable=""/> <bbox w="35.0" h="10.0" x="3680.5" y="4179.0"/> </glyph> <glyph class="state variable" id="_700573e1-2f34-4618-ac2d-15cfd845bcca"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="3666.595" y="4179.0"/> </glyph> <glyph class="state variable" id="_8c21f420-58ce-47b9-95aa-97dbc442379f"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="3699.9492" y="4179.0"/> </glyph> <glyph class="state variable" id="_456fa1e8-4a4f-4b31-8024-26f7fcf67e8b"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="3699.3306" y="4219.0"/> </glyph> <glyph class="state variable" id="_18af4f0d-ace6-47f4-87d4-1eba0b243879"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="3665.9756" y="4219.0"/> </glyph> <glyph class="state variable" id="_ec94361c-e54b-45aa-8243-a70a2fc9a8ef"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="3725.5" y="4199.0"/> </glyph> <glyph class="state variable" id="_d4b374e9-5957-4e2a-97c6-97f6a07c522b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3653.0" y="4199.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s935_sa498"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="3660.0" y="4240.0"/> <glyph class="state variable" id="_2d984d54-a991-46ec-8075-c16a151d734a"> <state value="-S-S-" variable=""/> <bbox w="35.0" h="10.0" x="3682.5" y="4235.0"/> </glyph> <glyph class="state variable" id="_6ff51105-e599-4820-b202-1b9a481352f1"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="3668.595" y="4235.0"/> </glyph> <glyph class="state variable" id="_99ac07ef-1934-4309-b985-a94fe1efbf9e"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="3701.9492" y="4235.0"/> </glyph> <glyph class="state variable" id="_5c0a7d2d-f8ab-4e72-a710-7a1a1eacca47"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="3701.3306" y="4275.0"/> </glyph> <glyph class="state variable" id="_0c745054-71f5-4fae-8c29-8eb383d0beac"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="3667.9756" y="4275.0"/> </glyph> <glyph class="state variable" id="_e39cdff3-68c2-40d6-a0ef-f7869fb0f980"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="3727.5" y="4255.0"/> </glyph> <glyph class="state variable" id="_75ebe69a-688d-4b20-84fa-26d3c1ac0c36"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3655.0" y="4255.0"/> </glyph> </glyph> </glyph> <glyph class="simple chemical" id="s936_sa408" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="1628.25" y="4334.75"/> </glyph> <glyph class="simple chemical" id="s936_sa501" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="3665.0" y="4107.5"/> </glyph> <glyph class="simple chemical" id="s936_sa2220" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="1207.75" y="4125.25"/> </glyph> <glyph class="simple chemical" id="s936_sa2531" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="3575.0" y="4357.5"/> </glyph> <glyph class="macromolecule" id="s946_sa606" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="3695.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s972_sa577" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: miR-17-92 cluster host gene (non-protein coding) HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6 Identifiers_end </body> </html> </notes> <label text="MIR17-92*"/> <bbox w="90.0" h="25.0" x="4220.0" y="7042.5"/> <glyph class="unit of information" id="_95a08e54-c936-42a2-8e76-f3ac11d702e7"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4250.0" y="7037.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s973_sa579" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 Identifiers_end References_begin: synonym:MIR-17-92 References_end </body> </html> </notes> <label text="MIR17"/> <bbox w="90.0" h="25.0" x="3575.966" y="6671.348"/> <glyph class="unit of information" id="_aecf3e15-5a3e-4349-a380-ef14cbf86e2d"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3605.966" y="6666.348"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s974_sa580" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 18a HUGO:MIR18A HGNC:31548 ENTREZ:406953 Identifiers_end </body> </html> </notes> <label text="MIR18A"/> <bbox w="90.0" h="25.0" x="3302.966" y="6670.348"/> <glyph class="unit of information" id="_8196d997-9246-4ddb-b293-07835fa1b00d"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3332.966" y="6665.348"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s975_sa581" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 19a HUGO:MIR19A HGNC:31574 ENTREZ:406979 Identifiers_end </body> </html> </notes> <label text="MIR19A"/> <bbox w="90.0" h="25.0" x="3216.966" y="6668.348"/> <glyph class="unit of information" id="_23034220-1513-47c7-8efd-1d420bb8fcca"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3246.966" y="6663.348"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s976_sa582" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 20a HUGO:MIR20A HGNC:31577 ENTREZ:406982 Identifiers_end </body> </html> </notes> <label text="MIR20A"/> <bbox w="90.0" h="25.0" x="3060.966" y="6677.348"/> <glyph class="unit of information" id="_e185bd74-8d26-4707-a9e2-c463a60ec8a4"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3090.966" y="6672.348"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s977_sa583" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 19b-1 HUGO:MIR19B1 HGNC:31575 ENTREZ:406980 Identifiers_end </body> </html> </notes> <label text="MIR19B1"/> <bbox w="90.0" h="25.0" x="3380.966" y="6669.348"/> <glyph class="unit of information" id="_c0a4edea-06de-4709-92f6-68037045cd5e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3410.966" y="6664.348"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s978_sa584" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 92a-1 HUGO:MIR92A1 HGNC:31643 ENTREZ:407048 Identifiers_end </body> </html> </notes> <label text="MIR92A1"/> <bbox w="90.0" h="25.0" x="3480.966" y="6670.348"/> <glyph class="unit of information" id="_c0646efa-2796-4dc4-a8b9-c2733ad6a852"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3510.966" y="6665.348"/> </glyph> </glyph> <glyph class="simple chemical" id="s993_sa811" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16905 KEGGCOMPOUND:C00354 CAS:488-69-7 Identifiers_end </body> </html> </notes> <label text="fructose-1,6P2"/> <bbox w="110.0" h="31.25" x="1085.0" y="1134.375"/> </glyph> <glyph class="nucleic acid feature" id="s997_sa589" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: minichromosome maintenance complex component 7 HUGO:MCM7 HGNC:6950 ENTREZ:4176 UNIPROT:P33993 Identifiers_end </body> </html> </notes> <label text="MCM7"/> <bbox w="90.0" h="25.0" x="4215.0" y="6937.5"/> <glyph class="unit of information" id="_ebd2f9b4-6c34-4a43-acbf-e8bdade750c7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4250.0" y="6932.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s999_sa590" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 25 HUGO:MIR25 HGNC:31609 ENTREZ:407014 Identifiers_end </body> </html> </notes> <label text="MIR25"/> <bbox w="90.0" h="25.0" x="3935.2593" y="6679.098"/> <glyph class="unit of information" id="_bd7c77af-fee2-40c3-8520-3c684e847453"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3965.2593" y="6674.098"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1000_sa591" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 106b HUGO:MIR106B HGNC:31495 ENTREZ:406900 Identifiers_end </body> </html> </notes> <label text="MIR106B"/> <bbox w="90.0" h="25.0" x="4027.2593" y="6683.098"/> <glyph class="unit of information" id="_dd097525-b630-4455-b649-50b22630e956"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4057.2593" y="6678.098"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1001_sa592" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 93 HUGO:MIR93 HGNC:31645 ENTREZ:407050 Identifiers_end </body> </html> </notes> <label text="MIR93"/> <bbox w="90.0" h="25.0" x="4135.2593" y="6683.098"/> <glyph class="unit of information" id="_81cfc4a5-bb33-42b8-8630-7b1f35329a41"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4165.2593" y="6678.098"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1002_sa587" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: minichromosome maintenance complex component 7 HUGO:MCM7 HGNC:6950 ENTREZ:4176 UNIPROT:P33993 Identifiers_end </body> </html> </notes> <label text="MCM7"/> <bbox w="70.0" h="25.0" x="4481.7593" y="7355.598"/> </glyph> <glyph class="nucleic acid feature" id="s1004_sa576" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: miR-17-92 cluster host gene (non-protein coding) HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6 Identifiers_end </body> </html> </notes> <label text="MIR17-92*"/> <bbox w="70.0" h="25.0" x="4242.5" y="7309.0"/> </glyph> <glyph class="nucleic acid feature" id="s1005_sa585" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="E2F1"/> <bbox w="90.0" h="25.0" x="4406.7593" y="7046.598"/> <glyph class="unit of information" id="_abd93aeb-315a-40ae-8c1a-28dd23af7f65"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4441.7593" y="7041.598"/> </glyph> </glyph> <glyph class="simple chemical" id="s1007_sa859" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16001 KEGGCOMPOUND:C00236 CAS:38168-82-0 Identifiers_end </body> </html> </notes> <label text="glycerate-1,3P2"/> <bbox w="70.0" h="25.0" x="1105.0" y="1617.5"/> </glyph> <glyph class="simple chemical" id="s1010_sa818" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16108 KEGGCOMPOUND:C00111 CAS:57-04-5 Identifiers_end References_begin: synonym:glycerone phosphate Dihydroxyacetone phosphate lies in the glycolysis metabolic pathway, and is one of the two products of breakdown of fructose 1,6-bisphosphate, along with glyceraldehyde 3-phosphate. References_end </body> </html> </notes> <label text="dihydroxyacetone-P"/> <bbox w="145.0" h="32.5" x="1217.5" y="1223.75"/> </glyph> <glyph class="simple chemical" id="s1011_sa819" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29052 KEGGCOMPOUND:C00118 CAS:591-57-1 Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="glyceraldehyde-3P"/> <bbox w="125.0" h="32.5" x="1077.5" y="1323.75"/> </glyph> <glyph class="nucleic acid feature" id="s1029_sa605" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="90.0" h="25.0" x="3644.0" y="7051.5"/> <glyph class="unit of information" id="_9465537c-da54-4e63-955b-cff83442fd14"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3679.0" y="7046.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1030_sa604" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 122 HUGO:MIR122 HGNC:31501 ENTREZ:406906 Identifiers_end </body> </html> </notes> <label text="MIR122"/> <bbox w="90.0" h="25.0" x="1960.7534" y="6635.108"/> <glyph class="unit of information" id="_bb1c8549-53cf-44d6-908d-83e179e267d7"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1990.7534" y="6630.108"/> </glyph> </glyph> <glyph class="macromolecule" id="s1053_sa494" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HCLS1 associated protein X-1 HUGO:HAX1 HGNC:16915 ENTREZ:10456 UNIPROT:O00165 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HAX1"/> <bbox w="80.0" h="40.0" x="3681.25" y="3982.877"/> </glyph> <glyph class="complex" id="s1057_csa36" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase9*:HAX1 Identifiers_end </body> </html> </notes> <label text="CASP9:HAX1"/> <bbox w="100.0" h="120.0" x="3530.0" y="3990.0"/> <glyph class="macromolecule" id="s1056_sa499"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HCLS1 associated protein X-1 HUGO:HAX1 HGNC:16915 ENTREZ:10456 UNIPROT:O00165 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HAX1"/> <bbox w="80.0" h="40.0" x="3539.0" y="4047.0"/> </glyph> <glyph class="macromolecule" id="s1058_sa500"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="3539.0" y="4005.0"/> <glyph class="state variable" id="_246e6498-1d10-49d6-96f5-d41fe4a56690"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="3547.595" y="4000.0"/> </glyph> <glyph class="state variable" id="_176a7e84-7405-4825-803f-ad67046d6609"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="3580.9492" y="4000.0"/> </glyph> <glyph class="state variable" id="_4b423388-4c07-419a-b391-f3123523c47c"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="3580.3306" y="4040.0"/> </glyph> <glyph class="state variable" id="_af589c25-8d68-4992-bb12-1c1292af38b9"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="3546.9756" y="4040.0"/> </glyph> <glyph class="state variable" id="_a17413af-c1e4-4f38-867d-05656a819063"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="3606.5" y="4020.0"/> </glyph> <glyph class="state variable" id="_3ff2af59-297f-47b7-af52-13836b2153fc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3534.0" y="4020.0"/> </glyph> </glyph> </glyph> <glyph class="simple chemical" id="s1059_sa771" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17634 KEGGCOMPOUND:C00031 CAS:50-99-7 Identifiers_end References_begin: PMID:12546687 References_end </body> </html> </notes> <label text="glucose"/> <clone/> <bbox w="70.0" h="25.0" x="675.0" y="657.5"/> </glyph> <glyph class="simple chemical" id="s1059_sa1016" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17634 KEGGCOMPOUND:C00031 CAS:50-99-7 Identifiers_end References_begin: PMID:12546687 References_end </body> </html> </notes> <label text="glucose"/> <clone/> <bbox w="70.0" h="25.0" x="8265.985" y="2636.6797"/> </glyph> <glyph class="simple chemical" id="s1060_sa770" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:4170 KEGGCOMPOUND:C00092 CAS:56-73-5 Identifiers_end </body> </html> </notes> <label text="glucose-6P"/> <bbox w="80.0" h="20.0" x="670.0" y="820.0"/> </glyph> <glyph class="simple chemical" id="s1061_sa791" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15946 KEGGCOMPOUND:C00085 CAS:643-13-0 Identifiers_end </body> </html> </notes> <label text="fructose-6P"/> <clone/> <bbox w="95.0" h="32.5" x="1072.5" y="883.75"/> </glyph> <glyph class="simple chemical" id="s1061_sa909" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15946 KEGGCOMPOUND:C00085 CAS:643-13-0 Identifiers_end </body> </html> </notes> <label text="fructose-6P"/> <clone/> <bbox w="95.0" h="22.5" x="539.24347" y="2645.625"/> </glyph> <glyph class="macromolecule" id="s1062_sa780" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 1 HUGO:HK1 hgnc_id:HGNC:4922 HGNC:4922 ENTREZ:3098 UNIPROT:P19367 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK1"/> <clone/> <bbox w="80.0" h="40.0" x="822.5" y="663.0"/> </glyph> <glyph class="macromolecule" id="s1062_sa5367" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 1 HUGO:HK1 hgnc_id:HGNC:4922 HGNC:4922 ENTREZ:3098 UNIPROT:P19367 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK1"/> <clone/> <bbox w="80.0" h="40.0" x="6300.0" y="3910.0"/> </glyph> <glyph class="macromolecule" id="s1063_sa779" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 2 HUGO:HK2 hgnc_id:HGNC:4923 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK2"/> <clone/> <bbox w="80.0" h="40.0" x="822.5" y="707.0"/> </glyph> <glyph class="macromolecule" id="s1063_sa5368" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 2 HUGO:HK2 hgnc_id:HGNC:4923 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK2"/> <clone/> <bbox w="80.0" h="40.0" x="6300.0" y="3970.0"/> </glyph> <glyph class="macromolecule" id="s1064_sa778" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 3 (white cell) HUGO:HK3 HGNC:4925 ENTREZ:3101 UNIPROT:P52790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="HK3"/> <bbox w="80.0" h="40.0" x="822.5" y="751.0"/> </glyph> <glyph class="macromolecule" id="s1065_sa777" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucokinase (hexokinase 4) HUGO:GCK HGNC:4195 ENTREZ:2645 UNIPROT:P35557 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GCK"/> <bbox w="80.0" h="40.0" x="822.5" y="795.0"/> </glyph> <glyph class="simple chemical" id="s1066_sa774" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:33184 KEGGCOMPOUND:C02843 Identifiers_end </body> </html> </notes> <label text="long-chain acyl-CoAs"/> <bbox w="150.5" h="28.0" x="704.75" y="616.0"/> </glyph> <glyph class="nucleic acid feature" id="s1076_sa111" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 133b HUGO:MIR133B HGNC:31759 ENTREZ:442890 Identifiers_end </body> </html> </notes> <label text="MIR133B"/> <bbox w="90.0" h="25.0" x="2045.6754" y="6644.992"/> <glyph class="unit of information" id="_9dd6f15f-ae7c-4839-a70b-98bb7e4a9cf9"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2075.6753" y="6639.992"/> </glyph> </glyph> <glyph class="macromolecule" id="s1084_sa764" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, muscle HUGO:PFKM HGNC:8877 ENTREZ:5213 UNIPROT:P08237 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PFKM"/> <clone/> <bbox w="80.0" h="40.0" x="7190.0" y="6910.0"/> </glyph> <glyph class="macromolecule" id="s1084_sa805" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, muscle HUGO:PFKM HGNC:8877 ENTREZ:5213 UNIPROT:P08237 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PFKM"/> <clone/> <bbox w="80.0" h="40.0" x="1532.0" y="1143.1896"/> </glyph> <glyph class="macromolecule" id="s1085_sa792" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, platelet HUGO:PFKP HGNC:8878 ENTREZ:5214 UNIPROT:Q01813 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKP"/> <bbox w="80.0" h="40.0" x="1534.0" y="1033.1896"/> </glyph> <glyph class="complex" id="s1097_csa47" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FBP*:Mg2+ Identifiers_end References_begin: stoechiometry: tetramer of FBP, FBP1 known to bind 3 Mg_super_2+_endsuper_ per subunit References_end </body> </html> </notes> <label text="FBP"/> <bbox w="118.0" h="96.0" x="1483.5" y="911.1896"/> <glyph class="simple chemical" id="s1102_sa845"> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1569.5" y="914.1896"/> </glyph> <glyph class="macromolecule multimer" id="s4436_sa3395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: fructose-1,6-bisphosphatase 1 HUGO:FBP1 HGNC:3606 ENTREZ:2203 UNIPROT:P09467 fructose-1,6-bisphosphatase 2 HUGO:FBP2 HGNC:3607 ENTREZ:8789 UNIPROT:O00757 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="FBP*"/> <bbox w="86.0" h="46.0" x="1490.0" y="939.0"/> <glyph class="unit of information" id="_620ecce5-b757-41e1-a0dc-8f318a1f0b3f"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="1523.0" y="934.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s1099_sa804" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: fructose-1,6-bisphosphatase 1 HUGO:FBP1 HGNC:3606 ENTREZ:2203 UNIPROT:P09467 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="FBP1"/> <bbox w="80.0" h="40.0" x="1784.5" y="961.1896"/> </glyph> <glyph class="macromolecule" id="s1100_sa799" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: fructose-1,6-bisphosphatase 2 HUGO:FBP2 HGNC:3607 ENTREZ:8789 UNIPROT:O00757 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="FBP2"/> <bbox w="80.0" h="40.0" x="1784.5" y="917.1896"/> </glyph> <glyph class="simple chemical" id="s1103_sa810" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="AMP"/> <clone/> <bbox w="70.0" h="25.0" x="1237.5" y="1052.5"/> </glyph> <glyph class="simple chemical" id="s1103_sa1013" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="AMP"/> <clone/> <bbox w="70.0" h="25.0" x="7926.0" y="2367.0"/> </glyph> <glyph class="simple chemical" id="s1103_sa2011" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="AMP"/> <clone/> <bbox w="70.0" h="25.0" x="364.24347" y="2755.625"/> </glyph> <glyph class="simple chemical" id="s1103_sa2786" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="AMP"/> <clone/> <bbox w="70.0" h="25.0" x="949.0" y="2899.5"/> </glyph> <glyph class="simple chemical" id="s1103_sa5323" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="AMP"/> <clone/> <bbox w="70.0" h="25.0" x="9142.5" y="1228.75"/> </glyph> <glyph class="simple chemical" id="s1104_sa790" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28602 KEGGCOMPOUND:C00665 Identifiers_end </body> </html> </notes> <label text="fructose-2,6P2"/> <bbox w="105.0" h="32.5" x="1337.5" y="885.0"/> </glyph> <glyph class="macromolecule" id="s1105_sa629" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase A, fructose-bisphosphate HUGO:ALDOA HGNC:414 ENTREZ:226 UNIPROT:P04075 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ALDOA"/> <clone/> <bbox w="80.0" h="40.0" x="5255.5" y="6922.0"/> </glyph> <glyph class="macromolecule" id="s1105_sa813" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase A, fructose-bisphosphate HUGO:ALDOA HGNC:414 ENTREZ:226 UNIPROT:P04075 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ALDOA"/> <clone/> <bbox w="80.0" h="40.0" x="900.0" y="1470.0"/> </glyph> <glyph class="macromolecule" id="s1106_sa816" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase B, fructose-bisphosphate HUGO:ALDOB HGNC:417 ENTREZ:229 UNIPROT:P05062 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALDOB"/> <bbox w="80.0" h="40.0" x="1000.0" y="1470.0"/> </glyph> <glyph class="macromolecule" id="s1107_sa817" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase C, fructose-bisphosphate HUGO:ALDOC HGNC:418 ENTREZ:230 UNIPROT:P09972 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALDOC"/> <bbox w="80.0" h="40.0" x="950.0" y="1520.0"/> </glyph> <glyph class="simple chemical" id="s1116_sa822" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="1157.5" y="1392.5"/> </glyph> <glyph class="simple chemical" id="s1116_sa893" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="1173.7163" y="2292.399"/> </glyph> <glyph class="simple chemical" id="s1116_sa2321" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="10171.0" y="1685.5"/> </glyph> <glyph class="simple chemical" id="s1116_sa5351" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="8347.5" y="1276.25"/> </glyph> <glyph class="simple chemical" id="s1116_sa5510" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15846 KEGGCOMPOUND:C00003 CAS:53-84-9 Identifiers_end References_begin: charge:+1 References_end </body> </html> </notes> <label text="NAD+"/> <clone/> <bbox w="70.0" h="25.0" x="11535.0" y="707.5"/> </glyph> <glyph class="simple chemical" id="s1122_sa1206" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end References_begin: PMID:10792026 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. References_end </body> </html> </notes> <label text="NO"/> <clone/> <bbox w="70.0" h="25.0" x="10959.0" y="1627.5"/> </glyph> <glyph class="simple chemical" id="s1122_sa2653" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end References_begin: PMID:10792026 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. References_end </body> </html> </notes> <label text="NO"/> <clone/> <bbox w="70.0" h="25.0" x="7115.0" y="4267.5"/> </glyph> <glyph class="simple chemical" id="s1122_sa2655" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end References_begin: PMID:10792026 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. References_end </body> </html> </notes> <label text="NO"/> <clone/> <bbox w="70.0" h="25.0" x="5458.0" y="1164.5"/> </glyph> <glyph class="simple chemical" id="s1122_sa2657" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end References_begin: PMID:10792026 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. References_end </body> </html> </notes> <label text="NO"/> <clone/> <bbox w="70.0" h="25.0" x="6655.0" y="5187.5"/> </glyph> <glyph class="simple chemical" id="s1122_sa3715" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end References_begin: PMID:10792026 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. References_end </body> </html> </notes> <label text="NO"/> <clone/> <bbox w="70.0" h="25.0" x="2405.0" y="1557.5"/> </glyph> <glyph class="macromolecule" id="s1125_sa761" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glyceraldehyde-3-phosphate dehydrogenase HUGO:GAPDH HGNC:4141 ENTREZ:2597 UNIPROT:P04406 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="GAPDH"/> <clone/> <bbox w="80.0" h="40.0" x="6670.0" y="6920.0"/> <glyph class="state variable" id="_29085c83-376b-43fa-b2a1-bed8531bedbb"> <state 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<bbox w="70.0" h="25.0" x="1105.0" y="1767.5"/> </glyph> <glyph class="simple chemical" id="s1136_sa5346" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17794 KEGGCOMPOUND:C00197 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="glycerate-3P"/> <clone/> <bbox w="85.0" h="22.5" x="8415.0" y="1267.5"/> </glyph> <glyph class="macromolecule" id="s1138_sa649" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged 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<notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglycerate mutase 1 (brain) HUGO:PGAM1 HGNC:8888 ENTREZ:5223 UNIPROT:P18669 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PGAM1"/> <bbox w="80.0" h="40.0" x="1314.7163" y="1798.8988"/> </glyph> <glyph class="simple chemical" id="s1141_sa874" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17835 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ENO*:Mg2+ Identifiers_end </body> </html> </notes> <label text="ENO"/> <bbox w="107.0" h="80.0" x="1216.7163" y="1977.8988"/> <glyph class="simple chemical" id="s1164_sa932"> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1290.23" y="1979.933"/> </glyph> <glyph class="macromolecule multimer" id="s4437_sa3396"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: enolase 1, (alpha) HUGO:ENO1 HGNC:3350 ENTREZ:2023 UNIPROT:P06733 enolase 2 (gamma, neuronal) HUGO:ENO2 HGNC:3353 ENTREZ:2026 UNIPROT:P09104 enolase 3 (beta, muscle) HUGO:ENO3 HGNC:3354 ENTREZ:2027 UNIPROT:P13929 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ENO*"/> <bbox w="86.0" h="46.0" x="1226.23" y="1994.933"/> <glyph class="unit of information" id="_884afc54-4978-4575-acb5-de0148d77e03"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1259.23" y="1989.933"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1170_csa55" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:K_super_+_endsuper_:Mg2+:PK* Identifiers_end </body> </html> </notes> <label text="active PK"/> <bbox w="118.0" h="98.0" x="1226.7163" y="2138.899"/> <glyph class="simple chemical" id="s1183_sa937"> <label text="K+"/> <bbox w="25.0" h="25.0" x="1232.9663" y="2190.899"/> </glyph> <glyph class="simple chemical" id="s1631_sa938"> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1310.9663" y="2142.899"/> </glyph> <glyph class="macromolecule multimer" id="s4439_sa3398"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate kinase, liver and RBC HUGO:PKLR HGNC:9020 ENTREZ:5313 UNIPROT:P30613 pyruvate kinase, muscle HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PK*"/> <bbox w="86.0" h="46.0" x="1242.7163" y="2158.899"/> <glyph class="unit of information" id="_e395439b-5acb-4d07-8961-2cbb8ea1ea53"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="1275.7163" y="2153.899"/> </glyph> </glyph> </glyph> <glyph class="simple chemical" id="s1176_sa889" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16995 Identifiers_end </body> </html> </notes> <label text="oxalate"/> <bbox w="70.0" h="25.0" x="1333.7163" y="2268.399"/> </glyph> <glyph class="macromolecule" id="s1177_sa260" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex assembly factor 1 HUGO:SDHAF1 HGNC:33867 ENTREZ:644096 UNIPROT:A6NFY7 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHAF1"/> <bbox w="80.0" h="40.0" x="744.25" y="4985.0"/> </glyph> <glyph class="macromolecule" id="s1178_sa881" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate kinase, liver and RBC HUGO:PKLR HGNC:9020 ENTREZ:5313 UNIPROT:P30613 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKLR"/> <bbox w="80.0" h="40.0" x="1426.7163" y="2123.899"/> </glyph> <glyph class="macromolecule" id="s1184_sa894" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lactate dehydrogenase A HUGO:LDHA HGNC:6535 ENTREZ:3939 UNIPROT:P00338 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="LDHA"/> <bbox w="80.0" h="40.0" x="1432.7163" y="2330.899"/> </glyph> <glyph class="macromolecule" id="s1185_sa904" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lactate dehydrogenase B HUGO:LDHB HGNC:6541 ENTREZ:3945 UNIPROT:P07195 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="LDHB"/> <bbox w="80.0" h="40.0" x="1432.7163" y="2374.899"/> </glyph> <glyph class="macromolecule" id="s1186_sa903" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lactate dehydrogenase C HUGO:LDHC HGNC:6544 ENTREZ:3948 UNIPROT:P07864 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: testis-specific References_end </body> </html> </notes> <label text="LDHC"/> <bbox w="80.0" h="40.0" x="1432.7163" y="2418.899"/> </glyph> <glyph class="simple chemical" id="s1190_sa902" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16651 KEGGCOMPOUND:C00186 CAS:79-33-4 Identifiers_end </body> </html> </notes> <label text="lactate"/> <bbox w="70.0" h="25.0" x="1115.0" y="2487.5"/> </glyph> <glyph class="macromolecule" id="s1193_sa1254" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: far upstream element (FUSE) binding protein 1 HUGO:FUBP1 HGNC:4004 ENTREZ:8880 UNIPROT:Q96AE4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="cleaved_FUBP1*"/> <bbox w="80.0" h="40.0" x="5082.5" y="7975.0"/> <glyph class="unit of information" id="_0e1fb544-c102-4c91-9246-4f69786aea21"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5097.5" y="7970.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1194_sa854" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 1 HUGO:SLC2A1 HGNC:11005 ENTREZ:6513 UNIPROT:P11166 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT1 References_end </body> </html> </notes> <label text="SLC2A1"/> <bbox w="80.0" h="40.0" x="800.0" y="200.0"/> </glyph> <glyph class="macromolecule" id="s1195_sa855" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 2 HUGO:SLC2A2 HGNC:11006 ENTREZ:6514 UNIPROT:P11168 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT2 References_end </body> </html> </notes> <label text="SLC2A2"/> <bbox w="80.0" h="40.0" x="602.5" y="195.0"/> </glyph> <glyph class="macromolecule" id="s1196_sa856" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 3 HUGO:SLC2A3 HGNC:11007 ENTREZ:6515 UNIPROT:P11169 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT3 References_end </body> </html> </notes> <label text="SLC2A3"/> <bbox w="80.0" h="40.0" x="702.5" y="195.0"/> </glyph> <glyph class="macromolecule" id="s1197_sa857" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 4 HUGO:SLC2A4 HGNC:11009 ENTREZ:6517 UNIPROT:P14672 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT4 References_end </body> </html> </notes> <label text="SLC2A4"/> <bbox w="80.0" h="40.0" x="500.0" y="200.0"/> </glyph> <glyph class="macromolecule" id="s1207_sa213" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 1 HUGO:PDK1 HGNC:8809 ENTREZ:5163 UNIPROT:Q15118 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDK1"/> <bbox w="80.0" h="40.0" x="2143.25" y="5949.0"/> </glyph> <glyph class="macromolecule" id="s1208_sa215" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 2 HUGO:PDK2 HGNC:8810 ENTREZ:5164 UNIPROT:Q15119 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDK2"/> <bbox w="80.0" h="40.0" x="2143.25" y="5991.0"/> </glyph> <glyph class="macromolecule" id="s1209_sa216" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 3 HUGO:PDK3 HGNC:8811 ENTREZ:5165 UNIPROT:Q15120 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDK3"/> <bbox w="80.0" h="40.0" x="2143.25" y="6033.0"/> </glyph> <glyph class="macromolecule" id="s1210_sa217" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 4 HUGO:PDK4 HGNC:8812 ENTREZ:5166 UNIPROT:Q16654 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDK4"/> <bbox w="80.0" h="40.0" x="2144.25" y="6075.0"/> </glyph> <glyph class="simple chemical" id="s1212_sa895" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15595 KEGGCOMPOUND:C00711 CAS:149-61-1 Identifiers_end References_begin: charge:2- References_end </body> </html> </notes> <label text="malate"/> <bbox w="70.0" h="25.0" x="835.71625" y="2272.5654"/> </glyph> <glyph class="simple chemical" id="s1217_sa807" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="805.0" y="1397.5"/> </glyph> <glyph class="simple chemical" id="s1217_sa891" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> 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<head> <title/> </head> <body>Identifiers_begin: CHEBI:16810 KEGGCOMPOUND:C00026 CAS:64-15-3 Identifiers_end </body> </html> </notes> <label text="2-oxoglutarate"/> <clone/> <bbox w="108.53373" h="24.780027" x="1134.9766" y="2645.735"/> </glyph> <glyph class="simple chemical" id="s1219_sa1973" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16810 KEGGCOMPOUND:C00026 CAS:64-15-3 Identifiers_end </body> </html> </notes> <label text="2-oxoglutarate"/> <clone/> <bbox w="70.0" h="25.0" x="235.0" y="4237.5"/> </glyph> <glyph class="simple chemical" id="s1219_sa5358" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16810 KEGGCOMPOUND:C00026 CAS:64-15-3 Identifiers_end </body> </html> </notes> <label text="2-oxoglutarate"/> <clone/> <bbox w="94.041664" h="24.666666" x="8292.5" y="1054.0834"/> </glyph> <glyph class="simple chemical" id="s1220_sa905" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16087 KEGGCOMPOUND:C00311 Identifiers_end References_begin: charge:3- References_end </body> </html> </notes> <label text="isocitrate"/> <bbox w="70.0" h="25.0" x="929.9766" y="2645.735"/> </glyph> <glyph class="nucleic acid feature" id="s1221_sa971" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: G0/G1switch 2 HUGO:G0S2 HGNC:30229 ENTREZ:50486 UNIPROT:P27469 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="G0S2"/> <bbox w="70.0" h="25.0" x="6703.326" y="7346.82"/> </glyph> <glyph class="complex" id="s1222_csa59" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IDH1:Mg2+ Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="IDH1"/> <bbox w="100.0" h="76.0" x="1023.9598" y="2714.024"/> <glyph class="macromolecule multimer" id="s4447_sa3411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: isocitrate dehydrogenase 1 (NADP+), soluble HUGO:IDH1 HGNC:5382 ENTREZ:3417 UNIPROT:O75874 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="IDH1"/> <bbox w="86.0" h="46.0" x="1028.9597" y="2727.024"/> <glyph class="unit of information" id="_d03b0f95-8584-4fca-b3fd-d463dbbca517"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1061.9597" y="2722.024"/> </glyph> </glyph> <glyph class="simple chemical" id="s4448_sa3412"> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1088.818" y="2716.4553"/> </glyph> </glyph> <glyph class="simple chemical" id="s1225_sa911" compartmentRef="c1_ca1"> <notes> <html 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id="s1257_sa568" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: chromosome 12 open reading frame 5 HUGO:C12orf5 HGNC:1185 ENTREZ:57103 UNIPROT:Q9NQ88 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TIGAR*"/> <bbox w="70.0" h="25.0" x="4072.0198" y="7329.3657"/> </glyph> <glyph class="macromolecule" id="s1280_sa3212" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cylindromatosis (turban tumor syndrome) HUGO:CYLD HGNC:2584 ENTREZ:1540 UNIPROT:Q9NQC7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: CYLD is required for necroptosis induction by deu- biquitinating RIP1 References_end </body> </html> </notes> <label text="CYLD"/> <bbox w="80.0" h="40.0" x="5134.5" y="1102.0"/> </glyph> <glyph class="nucleic acid feature" id="s1298_sa107" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 153-1 HUGO:MIR153-1 HGNC:31539 ENTREZ:406944 microRNA 153-2 HUGO:MIR153-2 HGNC:31540 ENTREZ:406945 Identifiers_end </body> </html> </notes> <label text="MIR153*"/> <bbox w="90.0" h="25.0" x="2125.6753" y="6649.992"/> <glyph class="unit of information" id="_6cad3e02-d4ad-4eae-8624-0192a56d5252"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2155.6753" y="6644.992"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1299_sa531" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 221 HUGO:MIR221 HGNC:31601 ENTREZ:407006 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23138871 References_end </body> </html> </notes> <label text="MIR221"/> <bbox w="90.0" h="25.0" x="2798.5" y="6685.0"/> <glyph class="unit of information" id="_d961ec17-9ecd-4140-93d7-028a8b110b9e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2828.5" y="6680.0"/> 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x="4697.13" y="7656.387"/> </glyph> <glyph class="state variable" id="_43e32b3f-1678-4e2f-bf95-7d960d3d263a"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="4730.6475" y="7656.387"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1321_sa570" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 Identifiers_end </body> </html> </notes> <label text="MIR34A"/> <bbox w="70.0" h="25.0" x="4162.5" y="7299.0"/> </glyph> <glyph class="nucleic acid feature" id="s1359_sa760" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glyceraldehyde-3-phosphate dehydrogenase HUGO:GAPDH HGNC:4141 ENTREZ:2597 UNIPROT:P04406 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="GAPDH"/> <bbox w="70.0" h="25.0" x="6862.8516" y="7311.4087"/> </glyph> <glyph class="nucleic acid feature" id="s1361_sa763" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, muscle HUGO:PFKM HGNC:8877 ENTREZ:5213 UNIPROT:P08237 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PFKM"/> <bbox w="70.0" h="25.0" x="6932.8516" y="7341.4087"/> </glyph> <glyph class="source and sink" id="s1409_sa1322" compartmentRef="c13_ca13"> <label text="s1409"/> <bbox w="30.0" h="30.0" x="3917.5" y="7660.0"/> </glyph> <glyph class="macromolecule" id="s1410_sa1321" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="3772.5" y="7655.0"/> <glyph class="state variable" id="_afef751c-9988-46ea-8f2d-24abf8e76fe3"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="3814.4492" y="7650.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1411_sa1325" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: homeodomain interacting protein kinase 2 HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="4012.5" y="7655.0"/> </glyph> <glyph class="macromolecule" id="s1412_sa1327" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="3772.5" y="7795.0"/> <glyph class="state variable" id="_42d05a51-a015-40f7-b884-311b6f809e05"> <state value="P" variable="S422"/> <bbox w="35.0" h="10.0" x="3811.9492" y="7790.0"/> </glyph> </glyph> <glyph class="complex" id="s1413_csa58" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ME1:Mg2+ Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: PMID:1088824 tetrameric enzyme References_end </body> </html> </notes> <label text="ME1"/> <bbox w="132.28374" h="82.434525" x="947.71625" y="2327.5654"/> <glyph class="simple chemical" id="s3413_sa949"> <label text="Mg2+"/> <bbox w="45.283733" h="36.43453" x="1034.7163" y="2333.5654"/> </glyph> <glyph class="macromolecule multimer" id="s4440_sa3399"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: malic enzyme 1, NADP(+)-dependent, cytosolic HUGO:ME1 HGNC:6983 ENTREZ:4199 UNIPROT:P48163 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ME1"/> <bbox w="86.0" h="46.0" x="954.71625" y="2339.5654"/> <glyph class="unit of information" id="_ac004528-926b-4f2f-a1e5-d4b7a313c1ad"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="987.71625" y="2334.5654"/> </glyph> </glyph> </glyph> <glyph class="simple chemical" id="s1416_sa802" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16863 KEGGCOMPOUND:C00345 CAS:921-62-0 Identifiers_end </body> </html> </notes> <label text="gluconate-6P"/> <bbox w="105.0" h="22.5" x="647.5" y="1318.75"/> </glyph> <glyph class="macromolecule" id="s1417_sa796" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphogluconolactonase HUGO:PGLS HGNC:8903 ENTREZ:25796 UNIPROT:O95336 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PGLS"/> <bbox w="80.0" h="40.0" x="592.5" y="1175.0"/> </glyph> <glyph class="macromolecule" id="s1418_sa801" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) HUGO:H6PD HGNC:4795 ENTREZ:9563 UNIPROT:O95479 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="H6PD"/> <bbox w="80.0" h="40.0" x="592.5" y="1125.0"/> </glyph> <glyph class="simple chemical" id="s1419_sa812" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17363 KEGGCOMPOUND:C00199 CAS:4151-19-3 Identifiers_end </body> </html> </notes> <label text="ribulose-5P"/> <bbox w="85.0" h="22.5" x="830.0" y="1323.75"/> </glyph> <glyph class="nucleic acid feature" id="s1420_sa512" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PTEN"/> <bbox w="70.0" h="25.0" x="3098.75" y="7344.0"/> </glyph> <glyph class="macromolecule" id="s1421_sa529" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:15721744 PMID:22465479 References_end </body> </html> </notes> <label text="PTEN"/> <clone/> <bbox w="80.0" h="40.0" x="2890.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s1421_sa4213" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:15721744 PMID:22465479 References_end </body> </html> </notes> <label text="PTEN"/> <clone/> <bbox w="80.0" h="40.0" x="3190.0" y="440.0"/> </glyph> <glyph class="macromolecule" id="s1423_sa896" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aconitase 1, soluble HUGO:ACO1 HGNC:117 ENTREZ:48 UNIPROT:P21399 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACO1"/> <bbox w="80.0" h="40.0" x="838.2266" y="2582.4138"/> <glyph class="state variable" id="_4a08930f-0f74-43f0-a9dd-bd8373893604"> <state value="4Fe-4S" variable=""/> <bbox w="40.0" h="10.0" x="858.2266" y="2577.4138"/> </glyph> </glyph> <glyph class="macromolecule" id="s1424_sa1424" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6900.0" y="4890.0"/> <glyph class="state variable" id="_aa5c4f44-9f93-47f7-ac11-7217a9085d23"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="6906.095" y="4885.0"/> </glyph> <glyph class="state variable" id="_7c71e16f-82ea-4a2f-be52-5a266411350d"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="6939.449" y="4885.0"/> </glyph> <glyph class="state variable" id="_3072b664-2082-4539-b520-443f1d6a8738"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="6938.8306" y="4925.0"/> </glyph> <glyph class="state variable" id="_79d711e2-efcf-4aae-bea5-fd588df57a11"> <state value="P" variable="S144"/> <bbox w="35.0" h="10.0" x="6905.4756" y="4925.0"/> </glyph> <glyph class="state variable" id="_14dace03-9f5c-4009-a2b8-decd6836bb6d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="6967.5" y="4905.0"/> </glyph> <glyph class="state variable" id="_e40be6ee-3f53-4f1e-863e-467e8972b7ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6895.0" y="4905.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s1425_sa1426" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:44658 KEGGCOMPOUND:C01945 CAS:78111-17-8 Identifiers_end </body> </html> </notes> <label text="Okadaic acid*"/> <bbox w="102.75" h="30.25" x="6758.625" y="4774.875"/> <glyph class="unit of information" id="_59650a65-f075-4a5e-94a9-c1b8d1b469ce"> <label text="drug"/> <bbox w="25.0" h="10.0" x="6797.5" y="4769.875"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1429_sa1332" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-interacting killer (apoptosis-inducing) HUGO:BIK HGNC:1051 ENTREZ:638 UNIPROT:Q13323 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BIK"/> <bbox w="90.0" h="25.0" x="2868.0" y="7049.75"/> <glyph class="unit of information" id="_5c9f1fff-ee0b-4638-a2de-476853c30256"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2903.0" y="7044.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s1430_sa1434" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 1, catalytic subunit, alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="PPP1CA"/> <bbox w="80.0" h="40.0" x="6820.0" y="3910.0"/> </glyph> <glyph class="macromolecule" id="s1431_sa1917" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: c-abl oncogene 1, non-receptor tyrosine kinase HUGO:ABL1 HGNC:76 ENTREZ:25 UNIPROT:P00519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="ABL1"/> <bbox w="80.0" h="40.0" x="7040.0" y="4960.0"/> </glyph> <glyph class="complex" id="s1433_csa125" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HECTH9*:p14ARF* Identifiers_end </body> </html> </notes> <label text="ARF:HUWE1"/> <bbox w="100.0" h="120.0" x="3672.5" y="7855.0"/> <glyph class="macromolecule" id="s1435_sa1335"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase HUGO:HUWE1 HGNC:30892 ENTREZ:10075 UNIPROT:Q7Z6Z7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:MULE References_end </body> </html> </notes> <label text="HECTH9*"/> <bbox w="80.0" h="40.0" x="3683.5" y="7910.0"/> </glyph> <glyph class="macromolecule" id="s2493_sa1336"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: uniprot:Q8N726 References_end </body> </html> </notes> <label text="p14ARF*"/> <bbox w="80.0" h="40.0" x="3681.5" y="7867.0"/> <glyph class="state variable" id="_60e33f9b-3d25-4fa1-9f96-0fcc9e7cca3c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3733.0686" y="7862.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s1434_sa335" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 3 (acute-phase response factor) HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:28186502 References_end </body> </html> </notes> <label text="STAT3"/> <bbox w="80.0" h="40.0" x="1218.0833" y="4650.6846"/> <glyph class="state variable" id="_7d4ee759-e123-444e-bcfb-f7a6639df1cd"> <state value="P" variable="S727"/> <bbox w="35.0" h="10.0" x="1257.5326" y="4645.6846"/> </glyph> </glyph> <glyph class="complex" id="s1438_csa303" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2:G0S2 Identifiers_end </body> </html> </notes> <label text="BCL2:G0S2"/> <bbox w="110.0" h="120.0" x="5065.0" y="4950.0"/> <glyph class="macromolecule" id="s1436_sa2587"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> HGNC:30229 PMID: 19706769 pro-apoptotic in H1299 Ad virus driven expression of G0S2 (but not of a R57A,D58A BCL2 interaction mutant) induces externalization of phosphatidylserines in primary fibroblasts, shRNA mediated knock-down abrogates the ability of TNF-a to increase the level of camptothecin-induced apoptosis ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: G0/G1switch 2 HUGO:G0S2 HGNC:30229 ENTREZ:50486 UNIPROT:P27469 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="G0S2"/> <bbox w="80.0" h="40.0" x="5083.0" y="5005.0"/> </glyph> <glyph class="macromolecule" id="s1437_sa2588"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5083.0" y="4961.0"/> <glyph class="state variable" id="_68eb7aea-e63c-4d76-97c5-036fa7311955"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5101.4316" y="4956.0"/> </glyph> <glyph class="state variable" id="_74a3e711-b587-495f-a58d-0f7f5324f092"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5134.5684" y="4956.0"/> </glyph> <glyph class="state variable" id="_53dd9e73-5a67-4f1d-9412-bc2973753ef3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5078.0" y="4976.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s1451_sa1288" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="4673.0" y="2639.0"/> <glyph class="state variable" id="_01e4fa91-91ad-4ebf-8499-3fdc86336a0d"> <state value="" variable="S98"/> <bbox w="25.0" h="10.0" x="4739.882" y="2674.0"/> </glyph> <glyph class="state variable" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BimEL* Identifiers_end </body> </html> </notes> <label text="14-3-3:BimEL"/> <bbox w="97.0" h="128.0" x="4520.5" y="2555.0"/> <glyph class="macromolecule" id="s1453_sa1302"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="4527.5" y="2615.0"/> <glyph class="state variable" id="_02dadfea-9daa-4cdd-9011-320989ddbf5f"> <state value="" variable="S98"/> <bbox w="25.0" h="10.0" x="4594.382" y="2650.0"/> </glyph> <glyph class="state variable" id="_350f76e7-f754-4d04-ac0c-24d24b2d61e5"> <state value="" variable="S69"/> <bbox w="25.0" h="10.0" x="4595.0" y="2610.0"/> </glyph> <glyph class="state variable" id="_09c75d3a-311f-4d7c-96a7-1b2ca8561cbc"> <state value="" variable="S93"/> <bbox w="25.0" h="10.0" x="4515.0" y="2649.7224"/> </glyph> <glyph class="state variable" id="_678a014e-9346-43ef-ae11-50b39764c708"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="4554.9043" y="2650.0"/> </glyph> <glyph class="state variable" id="_87db7816-4c9d-42bf-82d6-55eab03334a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4562.5" y="2610.0"/> </glyph> <glyph class="state variable" id="_237a54ec-6438-4ea5-ac6e-65dce126aed8"> <state value="P" variable="S87"/> <bbox w="30.0" h="10.0" x="4512.9927" y="2610.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1454_sa1303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4527.5" y="2565.0"/> <glyph class="state variable" id="_2949f93b-0068-45e8-a064-fd83a1a3a506"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4576.5977" y="2560.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1459_csa61" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO3:RUNX3 Identifiers_end </body> </html> </notes> <label text="FOXO3:RUNX3"/> <bbox w="100.0" h="110.0" x="5162.5" y="7680.0"/> <glyph class="macromolecule" id="s1460_sa977"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5172.5" y="7690.0"/> </glyph> <glyph class="macromolecule" id="s1461_sa978"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: runt-related transcription factor 3 HUGO:RUNX3 HGNC:10473 ENTREZ:864 UNIPROT:Q13761 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RUNX3"/> <bbox w="80.0" h="40.0" x="5172.5" y="7730.0"/> </glyph> </glyph> <glyph class="complex" id="s1475_csa120" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:DYNLL1 Identifiers_end </body> </html> </notes> <label text="BimL:dynein motor complex"/> <bbox w="100.0" h="120.0" x="4919.4526" y="3194.2307"/> <glyph class="macromolecule" id="s7610_sa1300"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dynein, light chain, LC8-type 1 HUGO:DYNLL1 HGNC:15476 ENTREZ:8655 UNIPROT:P63167 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: part of cytoskeletal structures with heavy and intermediary chains References_end </body> </html> </notes> <label text="DYNLL1"/> <bbox w="80.0" h="40.0" x="4928.4526" y="3250.2307"/> </glyph> <glyph class="macromolecule" id="s7611_sa1301"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4928.4526" y="3208.2307"/> <glyph class="state variable" id="_9c4dafaa-d2ab-4f76-a2dd-1f237cab7223"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4955.9844" y="3203.2307"/> </glyph> <glyph class="state variable" id="_d3a22d7d-8e3f-45ff-b6aa-15c8cbeda2b8"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4995.9526" y="3203.4456"/> </glyph> <glyph class="state variable" id="_fba25345-2870-49fc-9d5d-417e7b0bab2b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4980.252" y="3243.2307"/> </glyph> <glyph class="state variable" id="_bc8652e8-907f-41d9-bcc4-91efe38cbed3"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="4916.4453" y="3203.2307"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1476_csa123" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BimEL*:DYNLL1 Identifiers_end </body> </html> </notes> <label text="BimEL:dynein motor complex"/> <bbox w="100.0" h="120.0" x="4439.0" y="2755.0"/> <glyph class="macromolecule" id="s1478_sa1306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="4451.0" y="2766.0"/> <glyph class="state variable" id="_4b319697-0625-481a-aeb5-5ee88d0a0381"> <state value="" variable="S98"/> <bbox w="25.0" h="10.0" x="4517.882" y="2801.0"/> </glyph> <glyph class="state variable" id="_178ae128-4187-40d6-b5ee-877a730c5944"> <state value="" variable="S69"/> <bbox w="25.0" h="10.0" x="4518.5" y="2761.0"/> </glyph> <glyph class="state variable" id="_cc99af7c-b507-4b83-86f9-26084a00d121"> <state value="" variable="S93"/> <bbox w="25.0" h="10.0" x="4438.5" y="2800.7224"/> </glyph> <glyph class="state variable" id="_765049b2-eb77-4730-961b-d28e20774d32"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="4478.4043" y="2801.0"/> </glyph> <glyph class="state variable" id="_c97d4750-30aa-4978-99c2-3d2a9d165cd3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4486.0" y="2761.0"/> </glyph> <glyph class="state variable" id="_44a402cc-fa72-4b1c-a41e-ecbe602c4e31"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="4438.9927" y="2761.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1477_sa1307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dynein, light chain, LC8-type 1 HUGO:DYNLL1 HGNC:15476 ENTREZ:8655 UNIPROT:P63167 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: part of cytoskeletal structures with heavy and intermediary chains References_end </body> </html> </notes> <label text="DYNLL1"/> <bbox w="80.0" h="40.0" x="4450.0" y="2810.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1479_sa1291" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:RACK1 References_end </body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="4389.0" y="2970.0"/> </glyph> <glyph class="macromolecule" id="s1486_sa1292" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: BCL2L11 splice variant References_end </body> </html> </notes> <label text="BimEL*"/> <bbox w="80.0" h="40.0" x="4617.0474" y="3153.5193"/> <glyph class="state variable" id="_952a3cfe-9ddc-4c16-af82-96ab0eb48b35"> <state value="" variable="S98"/> <bbox w="25.0" h="10.0" x="4683.929" y="3188.5193"/> </glyph> <glyph class="state variable" id="_12a7d0c5-d2e8-4010-9f15-e3a414872059"> <state value="" variable="S69"/> <bbox w="25.0" h="10.0" x="4684.5474" y="3148.5193"/> </glyph> <glyph class="state variable" id="_5d052a93-b317-4110-ae83-58ec182da8da"> <state value="" variable="S93"/> <bbox w="25.0" h="10.0" x="4604.5474" y="3188.2417"/> </glyph> <glyph class="state variable" id="_86cc7b48-25b9-4e39-b2b9-c10b553fce58"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="4644.4517" y="3188.5193"/> </glyph> <glyph class="state variable" id="_77475f50-204e-44b3-9fc6-53c31b39018e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4647.0474" y="3148.5193"/> </glyph> <glyph class="state variable" id="_19e5db4b-c491-47f0-85ce-e450c5fe8b73"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="4605.04" y="3148.5193"/> </glyph> </glyph> <glyph class="source and sink" id="s1487_sa1293" compartmentRef="c1_ca1"> <label text="s1487"/> <bbox w="30.0" h="30.0" x="4457.9756" y="3273.1335"/> </glyph> <glyph class="complex" id="s1504_csa284" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAD:TXNRD1 Identifiers_end </body> </html> </notes> <label text="TXNRD"/> <bbox w="100.0" h="92.0" x="11489.0" y="1737.0"/> <glyph class="macromolecule" id="s1506_sa2280"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: thioredoxin reductase 1 HUGO:TXNRD1 HGNC:12437 ENTREZ:7296 UNIPROT:Q16881 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TXNRD1"/> <bbox w="80.0" h="40.0" x="11494.0" y="1743.25"/> </glyph> <glyph class="simple chemical" id="s1505_sa2281"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="11499.0" y="1772.75"/> </glyph> <glyph class="macromolecule" id="s1506_sa2282"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: thioredoxin reductase 1 HUGO:TXNRD1 HGNC:12437 ENTREZ:7296 UNIPROT:Q16881 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TXNRD1"/> <bbox w="80.0" h="40.0" x="11504.0" y="1753.25"/> </glyph> <glyph class="simple chemical" id="s1505_sa2283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="11509.0" y="1782.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s1507_sa2276" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 1 HUGO:PRDX1 HGNC:9352 ENTREZ:5052 UNIPROT:Q06830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PRDX1"/> <bbox w="80.0" h="40.0" x="11732.0" y="1572.0"/> </glyph> <glyph class="macromolecule" id="s1509_sa2277" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 2 HUGO:PRDX2 HGNC:9353 ENTREZ:7001 UNIPROT:P32119 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PRDX2"/> <bbox w="80.0" h="40.0" x="11731.0" y="1615.0"/> </glyph> <glyph class="simple chemical" id="s1515_sa2264" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="8179.75" y="6627.75"/> </glyph> <glyph class="simple chemical" id="s1515_sa2271" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="11644.0" y="1536.5"/> </glyph> <glyph class="simple chemical" id="s1515_sa2601" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="9237.0" y="639.5"/> </glyph> <glyph class="simple chemical" id="s1515_sa3257" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="6845.0" y="1737.5"/> </glyph> <glyph class="simple chemical" id="s1515_sa3333" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="5301.0" y="2315.5"/> </glyph> <glyph class="simple chemical" id="s1515_sa3373" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="H2O2"/> <clone/> <bbox w="70.0" h="25.0" x="3595.0" y="3607.5"/> </glyph> <glyph class="complex" id="s1516_csa56" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PKM2*:fructose-1,6P2 Identifiers_end </body> </html> </notes> <label text="active_PKM2"/> <bbox w="120.0" h="99.1012" x="1410.0" y="2210.899"/> <glyph class="macromolecule" id="s1179_sa939"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate kinase, muscle HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PKM2*"/> <bbox w="80.0" h="40.0" x="1430.0" y="2220.0"/> </glyph> <glyph class="simple chemical" id="s1517_sa940"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16905 KEGGCOMPOUND:C00354 CAS:488-69-7 </body> </html> </notes> <label text="fructose-1,6P2"/> <bbox w="107.5" h="21.25" x="1416.25" y="2259.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s1518_sa638" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate kinase, muscle HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PKM2*"/> <clone/> <bbox w="80.0" h="40.0" x="5340.0" y="6925.0"/> </glyph> <glyph class="macromolecule" id="s1518_sa886" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate kinase, muscle HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PKM2*"/> <clone/> <bbox w="80.0" h="40.0" x="1612.5" y="2265.0"/> </glyph> <glyph class="simple chemical" id="s1520_sa2529" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:60456 Identifiers_end </body> </html> </notes> <label text="oxidized_cardiolipin"/> <bbox w="70.0" h="25.0" x="3458.75" y="4528.5"/> </glyph> <glyph class="nucleic acid feature" id="s1522_sa611" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 HUGO:PFKFB3 HGNC:8874 ENTREZ:5209 UNIPROT:Q16875 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKFB3"/> <bbox w="70.0" h="25.0" x="5049.0" y="7313.5"/> </glyph> <glyph class="macromolecule" id="s1532_sa814" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribose 5-phosphate isomerase A HUGO:RPIA HGNC:10297 ENTREZ:22934 UNIPROT:P49247 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="RPIA"/> <bbox w="80.0" h="40.0" x="740.0" y="1450.0"/> </glyph> <glyph class="simple chemical" id="s1533_sa815" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17797 KEGGCOMPOUND:C00117 CAS:4300-28-1 Identifiers_end </body> </html> </notes> <label text="ribose-5P"/> <bbox w="70.0" h="25.0" x="836.0" y="1594.6896"/> </glyph> <glyph class="complex" id="s1547_csa24" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AIFM1:FAD Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="100.0" h="120.0" x="1329.1902" y="4620.7773"/> <glyph class="simple chemical" id="s1548_sa328"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="1338.1902" y="4687.7773"/> </glyph> <glyph class="macromolecule" id="s1549_sa329"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="1340.1902" y="4635.7773"/> <glyph class="state variable" id="_cb503b22-5167-4917-950e-05bfc853b300"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1376.6282" y="4630.7773"/> </glyph> </glyph> </glyph> <glyph class="phenotype" id="s1550_sa1893" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:24684389 References_end </body> </html> </notes> <label text="DNA~fragmentation"/> <bbox w="110.0" h="35.0" x="1142.5" y="7340.0"/> </glyph> <glyph class="macromolecule" id="s1552_sa1178" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="5772.5" y="7565.0"/> <glyph class="state variable" id="_fddb9841-3f2a-4b35-8367-3d67de038b74"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="5821.5684" y="7560.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1553_sa965" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="7060.0" y="3060.0"/> <glyph class="state variable" id="_7c15b36e-c43b-4fa8-acdb-42919b325823"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7078.4316" y="3055.0"/> </glyph> <glyph class="state variable" id="_41c1c953-e086-40b7-bda0-c1f83c856ef2"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="7104.449" y="3055.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1553_sa4171" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS 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compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="3580.0" y="610.0"/> <glyph class="state variable" id="_bf941801-efa8-4a26-8f20-78d6a86d00c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3598.4314" y="605.0"/> </glyph> <glyph class="state variable" id="_a7986d8d-f490-4e27-a033-cd42e483d476"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="3624.4492" y="605.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1553_sa4848" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="9753.4375" y="6840.0"/> <glyph class="state variable" id="_64ce258d-e82e-4327-b755-247b054e4281"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9771.869" y="6835.0"/> </glyph> <glyph class="state variable" id="_9cf0443f-df70-49a1-b3f2-d63aa9c36341"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="9797.887" y="6835.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1559_sa407" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SHC (Src homology 2 domain containing) transforming protein 1 HUGO:SHC1 HGNC:10840 ENTREZ:6464 UNIPROT:P29353 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: p66 specific isoform References_end </body> </html> </notes> <label text="SHC1_p66*"/> <bbox w="80.0" h="40.0" x="1730.25" y="4232.75"/> </glyph> <glyph class="simple chemical" id="s1561_sa386" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17976 KEGGCOMPOUND:C00390 Identifiers_end </body> </html> </notes> <label text="ubiquinol"/> <clone/> <bbox w="70.0" h="25.0" x="1691.75" y="5262.5"/> </glyph> <glyph class="simple chemical" id="s1561_sa2999" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17976 KEGGCOMPOUND:C00390 Identifiers_end </body> </html> </notes> <label text="ubiquinol"/> <clone/> <bbox w="70.0" h="25.0" x="649.25" y="4482.5"/> </glyph> <glyph class="simple chemical" id="s1562_sa347" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18421 KEGGCOMPOUND:C00704 CAS:11062-77-4 Identifiers_end </body> </html> </notes> <label text="O2-"/> <bbox w="70.0" h="25.0" x="1902.25" y="5557.0"/> </glyph> <glyph class="simple chemical" id="s1563_sa351" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 KEGGCOMPOUND:C00027 CAS:7722-84-1 Identifiers_end </body> </html> </notes> <label text="H2O2"/> <bbox w="70.0" h="25.0" x="2126.25" y="5558.0"/> </glyph> <glyph class="macromolecule" id="s1564_sa346" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: superoxide dismutase 2, mitochondrial 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<glyph class="macromolecule" id="s1583_sa3043" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 3 HUGO:PRDX3 HGNC:9354 ENTREZ:10935 UNIPROT:P30048 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PRDX3"/> <bbox w="80.0" h="40.0" x="2212.75" y="5625.5"/> <glyph class="state variable" id="_9a778e5b-1740-4a6c-9d77-255fdcd44095"> <state value="-SOH" variable=""/> <bbox w="30.0" h="10.0" x="2237.75" y="5620.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1584_sa357" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 3 HUGO:PRDX3 HGNC:9354 ENTREZ:10935 UNIPROT:P30048 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PRDX3"/> <bbox w="80.0" h="40.0" x="2360.25" y="5627.0"/> <glyph class="state variable" id="_66e70869-ef58-459f-a3db-4bab813a5052"> <state value="-S-S-" variable=""/> <bbox w="35.0" h="10.0" x="2382.75" y="5622.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1585_sa355" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 3 HUGO:PRDX3 HGNC:9354 ENTREZ:10935 UNIPROT:P30048 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PRDX3"/> <bbox w="80.0" h="40.0" x="2214.25" y="5735.0"/> <glyph class="state variable" id="_1313e6c5-3307-4c42-bb85-c81ed021db39"> <state value="-SO2H" variable=""/> <bbox w="35.0" h="10.0" x="2236.75" y="5730.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1586_sa360" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin 2 HUGO:TXN2 HGNC:17772 ENTREZ:25828 UNIPROT:Q99757 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="TXN2"/> <bbox w="80.0" h="40.0" x="2424.25" y="5578.0"/> </glyph> <glyph class="macromolecule" id="s1587_sa359" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin reductase 2 HUGO:TXNRD2 HGNC:18155 ENTREZ:10587 UNIPROT:Q9NNW7 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="TXNRD2"/> <bbox w="80.0" h="40.0" x="2590.25" y="5532.0"/> </glyph> <glyph class="complex" id="s1590_csa135" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:HSP70* Identifiers_end </body> </html> </notes> <label text="APAF1:HSP70"/> <bbox w="100.0" h="120.0" x="6840.0" y="5930.0"/> <glyph class="macromolecule" id="s1592_sa1407"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6852.0" y="5939.0"/> </glyph> <glyph class="macromolecule" id="s1591_sa1408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 heat shock 70kDa protein 1B HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 heat shock 70kDa protein 1-like HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="6852.0" y="5979.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1601_sa1948" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: synonym:cathepsins References_end </body> </html> </notes> <label text="CTSB"/> <bbox w="80.0" h="40.0" x="447.75" y="4026.0"/> <glyph class="state variable" id="_cc3b07f4-561e-45b0-a2c3-656042c8c44f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="442.75" y="4041.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1602_sa1946" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin S HUGO:CTSS HGNC:2545 ENTREZ:1520 UNIPROT:P25774 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CTSS"/> <bbox w="80.0" h="40.0" x="467.75" y="3964.0"/> </glyph> <glyph class="macromolecule" id="s1603_sa1947" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin L1 HUGO:CTSL1 HGNC:2537 ENTREZ:1514 UNIPROT:P07711 cathepsin L2 HUGO:CTSL2 HGNC:2538 ENTREZ:1515 UNIPROT:O60911 cathepsin L family member 3, pseudogene HUGO:CTSL3P HGNC:33132 ENTREZ:392360 UNIPROT:Q5NE16 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CTSL*"/> <bbox w="80.0" h="40.0" x="527.75" y="3914.0"/> </glyph> <glyph class="nucleic acid feature" id="s1604_sa614" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 1 HUGO:PDK1 HGNC:8809 ENTREZ:5163 UNIPROT:Q15118 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDK1"/> <bbox w="70.0" h="25.0" x="5129.0" y="7343.5"/> </glyph> <glyph class="nucleic acid feature" id="s1606_sa607" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 2 HUGO:HK2 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="HK2"/> <bbox w="70.0" h="25.0" x="5048.781" y="7345.822"/> </glyph> <glyph class="nucleic acid feature" id="s1612_sa1140" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="90.0" h="25.0" x="2928.0" y="7079.75"/> <glyph class="unit of information" id="_39b8e23d-fcd5-4238-8705-432602f4630a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2963.0" y="7074.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1613_sa1218" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:p27 synonym:Kip1 References_end </body> </html> </notes> <label text="p27KIP1*"/> <bbox w="90.0" h="25.0" x="4723.0" y="7058.5"/> <glyph class="unit of information" id="_9efea6d4-85da-4c4c-9342-86553aba7b4d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4758.0" y="7053.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1616_sa1217" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:p27 synonym:Kip1 References_end </body> </html> </notes> <label text="p27KIP1*"/> <bbox w="70.0" h="25.0" x="4659.0" y="7323.5"/> </glyph> <glyph class="macromolecule" id="s1618_sa1253" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: far upstream element (FUSE) binding protein 1 HUGO:FUBP1 HGNC:4004 ENTREZ:8880 UNIPROT:Q96AE4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FUBP1"/> <bbox w="80.0" h="40.0" x="5082.5" y="7875.0"/> </glyph> <glyph class="nucleic acid feature" id="s1619_sa601" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <bbox w="70.0" h="25.0" x="4969.0" y="7313.5"/> </glyph> <glyph class="complex" id="s1623_csa116" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:N1ICD*:YY1 Identifiers_end </body> </html> </notes> <label text="N1ICD:YY1"/> <bbox w="100.0" h="120.0" x="5512.5" y="7555.0"/> <glyph class="macromolecule" id="s1628_sa1273"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: YY1 transcription factor HUGO:YY1 HGNC:12856 ENTREZ:7528 UNIPROT:P25490 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="YY1"/> <bbox w="80.0" h="40.0" x="5522.5" y="7605.0"/> </glyph> <glyph class="macromolecule" id="s1624_sa1274"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: notch 1 HUGO:NOTCH1 HGNC:7881 ENTREZ:4851 UNIPROT:P46531 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: proteolytically activated NOTCH1 References_end </body> </html> </notes> <label text="N1ICD*"/> <bbox w="80.0" h="40.0" x="5522.5" y="7565.0"/> <glyph class="unit of information" id="_90080423-573a-4174-8829-53c372b806a0"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5537.5" y="7560.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s1640_sa1277" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: notch 1 HUGO:NOTCH1 HGNC:7881 ENTREZ:4851 UNIPROT:P46531 Identifiers_end </body> </html> </notes> <label text="NOTCH1"/> <bbox w="80.0" h="40.0" x="5230.0" y="8170.0"/> </glyph> <glyph class="complex" id="s1643_csa250" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DFFA:DFFB Identifiers_end </body> </html> </notes> <label text="DFFA:DFFB"/> <bbox w="100.0" h="120.0" x="822.0" y="6654.0"/> <glyph class="macromolecule" id="s940_sa1894"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA fragmentation factor, 45kDa, alpha polypeptide HUGO:DFFA HGNC:2772 ENTREZ:1676 UNIPROT:O00273 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:ICAD References_end </body> </html> </notes> <label text="DFFA"/> <bbox w="80.0" h="40.0" x="831.0" y="6663.0"/> </glyph> <glyph class="macromolecule" id="s1645_sa1895"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) HUGO:DFFB HGNC:2773 ENTREZ:1677 UNIPROT:O76075 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:CAD References_end </body> </html> </notes> <label text="DFFB"/> <bbox w="80.0" h="40.0" x="829.0" y="6705.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1647_sa1890" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) HUGO:DFFB HGNC:2773 ENTREZ:1677 UNIPROT:O76075 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:CAD References_end </body> </html> </notes> <label text="DFFB"/> <bbox w="80.0" h="40.0" x="1058.0" y="6694.0"/> </glyph> <glyph class="complex" id="s1649_csa251" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LMNA Identifiers_end </body> </html> </notes> <label text="LAMIN-A/C"/> <bbox w="117.0" h="81.0" x="5493.5" y="7894.0"/> <glyph class="macromolecule" id="s1650_sa1898"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: lamin A/C HUGO:LMNA HGNC:6636 ENTREZ:4000 UNIPROT:P02545 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:LAMIN-A/C References_end </body> </html> </notes> <label text="LMNA"/> <bbox w="80.0" h="40.0" x="5503.5" y="7898.0"/> </glyph> <glyph class="macromolecule" id="s1650_sa1899"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: lamin A/C HUGO:LMNA HGNC:6636 ENTREZ:4000 UNIPROT:P02545 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:LAMIN-A/C References_end </body> </html> </notes> <label text="LMNA"/> <bbox w="80.0" h="40.0" x="5523.5" y="7908.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1651_sa1897" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: laminin, alpha 1 HUGO:LAMA1 HGNC:6481 ENTREZ:284217 UNIPROT:P25391 laminin, alpha 2 HUGO:LAMA2 HGNC:6482 ENTREZ:3908 UNIPROT:P24043 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="cleaved_LAMA1_2*"/> <bbox w="80.0" h="40.0" x="5722.5" y="7915.0"/> <glyph class="unit of information" id="_936f02ed-db11-46ec-aee8-e7d5a5ea39a9"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5737.5" y="7910.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1652_sa486" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 6, apoptosis-related cysteine peptidase HUGO:CASP6 HGNC:1507 ENTREZ:839 UNIPROT:P55212 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="Caspase6*"/> <bbox w="80.0" h="40.0" x="7330.0" y="4190.0"/> </glyph> <glyph class="nucleic acid feature" id="s1657_sa566" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="70.0" h="25.0" x="4081.7593" y="7295.598"/> </glyph> <glyph class="nucleic acid feature" id="s1658_sa505" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 Identifiers_end </body> </html> </notes> <label text="MIR34A"/> <bbox w="90.0" h="25.0" x="2316.3494" y="6759.7344"/> <glyph class="unit of information" id="_48e3a8f9-c15c-42d1-a25e-6a21861e42ce"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2346.3494" y="6754.7344"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1659_sa967" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sulfiredoxin 1 HUGO:SRXN1 HGNC:16132 ENTREZ:140809 UNIPROT:Q9BYN0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SRXN1"/> <bbox w="70.0" h="25.0" x="6623.326" y="7306.82"/> </glyph> <glyph class="nucleic acid feature" id="s1663_sa757" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lactate dehydrogenase A HUGO:LDHA HGNC:6535 ENTREZ:3939 UNIPROT:P00338 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="LDHA"/> <bbox w="70.0" h="25.0" x="6859.9995" y="7341.842"/> </glyph> <glyph class="nucleic acid feature" id="s1665_sa618" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lon peptidase 1, mitochondrial HUGO:LONP1 HGNC:9479 ENTREZ:9361 UNIPROT:P36776 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="LONP1"/> <bbox w="70.0" h="25.0" x="5133.0" y="7308.5"/> </glyph> <glyph class="macromolecule" id="s1666_sa469" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit IV isoform 2 (lung) HUGO:COX4I2 HGNC:16232 ENTREZ:84701 UNIPROT:Q96KJ9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX4I2"/> <bbox w="80.0" h="40.0" x="1956.75" y="4555.0"/> </glyph> <glyph class="nucleic acid feature" id="s1678_sa622" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit IV isoform 2 (lung) HUGO:COX4I2 HGNC:16232 ENTREZ:84701 UNIPROT:Q96KJ9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX4I2"/> <bbox w="70.0" h="25.0" x="5204.5" y="7347.5"/> </glyph> <glyph class="macromolecule" id="s1714_sa785" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucose-6-phosphate isomerase HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GPI"/> <bbox w="80.0" h="40.0" x="1100.0" y="740.0"/> <glyph class="state variable" id="_8e3505ed-9a32-4c85-9c9b-011af32a8a51"> <state value="" variable="S185"/> <bbox w="30.0" h="10.0" x="1141.9493" y="735.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1715_sa631" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucose-6-phosphate isomerase HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GPI"/> <bbox w="70.0" h="25.0" x="5288.5" y="7312.5"/> </glyph> <glyph class="nucleic acid feature" id="s1717_sa634" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 1 HUGO:SLC2A1 HGNC:11005 ENTREZ:6513 UNIPROT:P11166 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT1 References_end </body> </html> </notes> <label text="SLC2A1"/> <bbox w="70.0" h="25.0" x="5380.5" y="7346.5"/> </glyph> <glyph class="nucleic acid feature" id="s1718_sa625" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 HUGO:PFKFB4 HGNC:8875 ENTREZ:5210 UNIPROT:Q16877 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PFKFB4"/> <bbox w="70.0" h="25.0" x="5208.5" y="7312.5"/> </glyph> <glyph class="nucleic acid feature" id="s1721_sa628" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase A, fructose-bisphosphate HUGO:ALDOA HGNC:414 ENTREZ:226 UNIPROT:P04075 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ALDOA"/> <bbox w="70.0" h="25.0" x="5293.0" y="7348.5"/> </glyph> <glyph class="macromolecule" id="s1722_sa641" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: triosephosphate isomerase 1 HUGO:TPI1 HGNC:12009 ENTREZ:7167 UNIPROT:P60174 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23988223 References_end </body> </html> </notes> <label text="TPI1"/> <clone/> <bbox w="80.0" h="40.0" x="5432.0" y="6923.0"/> </glyph> <glyph class="macromolecule" id="s1722_sa821" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: triosephosphate isomerase 1 HUGO:TPI1 HGNC:12009 ENTREZ:7167 UNIPROT:P60174 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23988223 References_end </body> </html> </notes> <label text="TPI1"/> <clone/> <bbox w="80.0" h="40.0" x="1402.5" y="1385.0"/> </glyph> <glyph class="nucleic acid feature" id="s1723_sa640" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: triosephosphate isomerase 1 HUGO:TPI1 HGNC:12009 ENTREZ:7167 UNIPROT:P60174 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="TPI1"/> <bbox w="70.0" h="25.0" x="5456.3335" y="7348.0"/> </glyph> <glyph class="nucleic acid feature" id="s1724_sa654" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 3 HUGO:PDK3 HGNC:8811 ENTREZ:5165 UNIPROT:Q15120 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDK3"/> <bbox w="70.0" h="25.0" x="5534.3335" y="7310.0"/> </glyph> <glyph class="nucleic acid feature" id="s1725_sa637" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate kinase, muscle HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618 Identifiers_end </body> </html> </notes> <label text="PKM2"/> <bbox w="70.0" h="25.0" x="5368.5" y="7312.5"/> </glyph> <glyph class="nucleic acid feature" id="s1726_sa648" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglycerate kinase 1 HUGO:PGK1 HGNC:8896 ENTREZ:5230 UNIPROT:P00558 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PGK1"/> <bbox w="70.0" h="25.0" x="5608.5" y="7344.5"/> </glyph> <glyph class="nucleic acid feature" id="s1727_sa643" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2/adenovirus E1B 19kDa interacting protein 3 HUGO:BNIP3 HGNC:1084 ENTREZ:664 UNIPROT:Q12983 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="BNIP3"/> <bbox w="70.0" h="25.0" x="5454.3335" y="7310.0"/> </glyph> <glyph class="macromolecule" id="s1728_sa644" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2/adenovirus E1B 19kDa interacting protein 3 HUGO:BNIP3 HGNC:1084 ENTREZ:664 UNIPROT:Q12983 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="BNIP3"/> <bbox w="80.0" h="40.0" x="8885.0" y="3315.0"/> </glyph> <glyph class="nucleic acid feature" id="s1729_sa652" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: carbonic anhydrase IX HUGO:CA9 HGNC:1383 ENTREZ:768 UNIPROT:Q16790 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CA9"/> <bbox w="70.0" h="25.0" x="5534.3335" y="7346.5"/> </glyph> <glyph class="macromolecule" id="s1730_sa651" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: carbonic anhydrase IX HUGO:CA9 HGNC:1383 ENTREZ:768 UNIPROT:Q16790 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CA9"/> <bbox w="80.0" h="40.0" x="5600.0" y="6930.0"/> </glyph> <glyph class="macromolecule" id="s1732_sa913" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP citrate lyase HUGO:ACLY HGNC:115 ENTREZ:47 UNIPROT:P53396 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACLY"/> <bbox w="80.0" h="40.0" x="559.24347" y="2698.125"/> <glyph class="state variable" id="_3a3415c8-d163-467b-af6a-f476e5eab7ac"> <state value="" variable="S454"/> <bbox w="30.0" h="10.0" x="601.19275" y="2693.125"/> </glyph> </glyph> <glyph class="macromolecule" id="s1735_sa912" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP citrate lyase HUGO:ACLY HGNC:115 ENTREZ:47 UNIPROT:P53396 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACLY"/> <bbox w="80.0" h="40.0" x="565.9598" y="2795.024"/> <glyph class="state variable" id="_9198eefe-8b4d-4f12-8a89-ece07b7dea57"> <state value="P" variable="S454"/> <bbox w="35.0" h="10.0" x="605.40906" y="2790.024"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1737_sa1333" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-interacting killer (apoptosis-inducing) HUGO:BIK HGNC:1051 ENTREZ:638 UNIPROT:Q13323 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BIK"/> <bbox w="70.0" h="25.0" x="3004.5" y="7312.0"/> </glyph> <glyph class="macromolecule" id="s1738_sa1318" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: uniprot:Q8N726 References_end </body> </html> </notes> <label text="p14ARF*"/> <bbox w="80.0" h="40.0" x="3392.5" y="7895.0"/> <glyph class="state variable" id="_8c31ad80-1757-47af-b761-f6077d458668"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3444.0686" y="7890.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1739_sa1410" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: APAF1 interacting protein HUGO:APIP HGNC:17581 ENTREZ:51074 UNIPROT:Q96GX9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="APIP"/> <bbox w="80.0" h="40.0" x="6470.0" y="6110.0"/> </glyph> <glyph class="complex" id="s1740_csa136" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:APIP Identifiers_end </body> </html> </notes> <label text="APAF1:APIP"/> <bbox w="100.0" h="120.0" x="6660.0" y="6100.0"/> <glyph class="macromolecule" id="s1742_sa1411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: APAF1 interacting protein HUGO:APIP HGNC:17581 ENTREZ:51074 UNIPROT:Q96GX9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="APIP"/> <bbox w="80.0" h="40.0" x="6670.0" y="6150.0"/> </glyph> <glyph class="macromolecule" id="s1749_sa1412"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6670.0" y="6110.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1743_sa999" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: synonym:PDK1PMID:17604717 References_end </body> </html> </notes> <label text="PDPK1"/> <clone/> <bbox w="80.0" h="40.0" x="8872.0" y="1726.0"/> </glyph> <glyph class="macromolecule" id="s1743_sa4194" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: synonym:PDK1PMID:17604717 References_end </body> </html> </notes> <label text="PDPK1"/> <clone/> <bbox w="80.0" h="40.0" x="3300.0" y="440.0"/> </glyph> <glyph class="macromolecule" id="s1744_sa18" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenylate kinase 2 HUGO:AK2 HGNC:362 ENTREZ:204 UNIPROT:P54819 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="AK2"/> <bbox w="80.0" h="40.0" x="5330.0" y="6390.0"/> </glyph> <glyph class="macromolecule" id="s1746_sa1402" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis, caspase activation inhibitor HUGO:AVEN HGNC:13509 ENTREZ:57099 UNIPROT:Q9NQS1 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="AVEN"/> <bbox w="80.0" h="40.0" x="6790.0" y="6100.0"/> </glyph> <glyph class="complex" id="s1747_csa134" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:AVEN Identifiers_end </body> </html> </notes> <label text="APAF1:AVEN"/> <bbox w="100.0" h="120.0" x="6980.0" y="6090.0"/> <glyph class="macromolecule" id="s4915_sa1403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptosis, caspase activation inhibitor HUGO:AVEN HGNC:13509 ENTREZ:57099 UNIPROT:Q9NQS1 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="AVEN"/> <bbox w="80.0" h="40.0" x="6988.75" y="6146.474"/> </glyph> <glyph class="macromolecule" id="s3110_sa1404"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6988.75" y="6106.474"/> </glyph> </glyph> <glyph class="macromolecule" id="s1750_sa1380" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: prothymosin, alpha HUGO:PTMA HGNC:9623 ENTREZ:5757 UNIPROT:P06454 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="PTMA"/> <bbox w="80.0" h="40.0" x="6298.25" y="6071.0"/> </glyph> <glyph class="macromolecule" id="s1757_sa38" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 2 References_end </body> </html> </notes> <label text="VDAC2"/> <bbox w="80.0" h="40.0" x="5767.71" y="5595.4976"/> </glyph> <glyph class="complex" id="s1760_csa3" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAK1:VDAC2 Identifiers_end </body> </html> </notes> <label text="BAK1:VDAC2"/> <bbox w="100.0" h="120.0" x="5280.0" y="5660.0"/> <glyph class="macromolecule" id="s1758_sa40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 2 References_end </body> </html> </notes> <label text="VDAC2"/> <bbox w="80.0" h="40.0" x="5289.0" y="5712.5"/> </glyph> <glyph class="macromolecule" id="s1759_sa41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="5289.0" y="5668.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1764_sa277" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 HUGO:NDUFAF2 HGNC:28086 ENTREZ:91942 UNIPROT:Q8N183 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFAF2"/> <bbox w="80.0" h="40.0" x="614.25" y="4885.0"/> </glyph> <glyph class="source and sink" id="s1765_sa276" compartmentRef="c4_ca4"> <label text="s1765"/> <bbox w="30.0" h="30.0" x="549.25" y="4810.0"/> </glyph> <glyph class="nucleic acid feature" id="s1766_sa767" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 HUGO:NDUFAF2 HGNC:28086 ENTREZ:91942 UNIPROT:Q8N183 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFAF2"/> <bbox w="70.0" h="25.0" x="6939.977" y="7309.7983"/> </glyph> <glyph class="complex" id="s1769_csa22" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ACAD9:ECSIT:NDUFAF1 Identifiers_end </body> </html> </notes> <label text="ECSIT:NDUFAF1"/> <bbox w="97.0" h="167.0" x="625.75" y="4631.5"/> <glyph class="macromolecule" id="s1767_sa280"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 HUGO:NDUFAF1 HGNC:18828 ENTREZ:51103 UNIPROT:Q9Y375 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFAF1"/> <bbox w="80.0" h="40.0" x="633.75" y="4732.5"/> </glyph> <glyph class="macromolecule" id="s1768_sa281"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ECSIT homolog (Drosophila) HUGO:ECSIT HGNC:29548 ENTREZ:51295 UNIPROT:Q9BQ95 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ECSIT"/> <bbox w="80.0" h="40.0" x="633.75" y="4688.5"/> </glyph> <glyph class="macromolecule" id="s4477_sa3434"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: acyl-CoA dehydrogenase family, member 9 HUGO:ACAD9 HGNC:21497 ENTREZ:28976 UNIPROT:Q9H845 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: PMID:26989860 References_end </body> </html> </notes> <label text="ACAD9"/> <bbox w="80.0" h="40.0" x="634.5599" y="4640.725"/> </glyph> </glyph> <glyph class="simple chemical" id="s1770_sa2231" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end </body> </html> </notes> <label text="NO"/> <bbox w="70.0" h="25.0" x="1409.25" y="4144.5"/> </glyph> <glyph class="macromolecule" id="s1771_sa1489" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 3 (acute-phase response factor) HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:28186502 References_end </body> </html> </notes> <label text="STAT3"/> <bbox w="80.0" h="40.0" x="7277.5" y="6329.0"/> <glyph class="state variable" id="_3ad075b8-85bf-4b71-a746-7d277797590e"> <state value="P" variable="S727"/> <bbox w="35.0" h="10.0" 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feature" id="s1772_sa4849" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="70.0" h="25.0" x="9757.266" y="7183.5"/> </glyph> <glyph class="macromolecule" id="s1781_sa3294" compartmentRef="c1_ca1"> <notes> <html 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<glyph class="macromolecule" id="s1784_sa3301" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peptidylprolyl cis/trans isomerase, NIMA-interacting 1 HUGO:PIN1 HGNC:8988 ENTREZ:5300 UNIPROT:Q13526 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="PIN1"/> <bbox w="80.0" h="40.0" x="5270.0" y="1730.0"/> </glyph> <glyph class="macromolecule" id="s1785_sa3302" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-rel reticuloendotheliosis viral oncogene homolog A (avian) HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RELA"/> <bbox w="80.0" h="40.0" x="5190.0" y="1646.0"/> <glyph class="state variable" id="_d3c2b083-9f91-4393-b74d-a5ca52087e11"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5208.4316" y="1681.0"/> </glyph> <glyph class="state variable" id="_67edd4aa-6ccc-4fa6-99bc-e82d94a6b0cf"> <state value="P" variable="T254"/> <bbox w="35.0" h="10.0" x="5228.423" y="1681.0"/> 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reticuloendotheliosis viral oncogene homolog A (avian) HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RELA"/> <bbox w="80.0" h="40.0" x="5493.75" y="1645.0"/> <glyph class="state variable" id="_1529ff9c-eaec-475b-acd8-fc571e2298db"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5507.1816" y="1680.0"/> </glyph> <glyph class="state variable" id="_b64ae871-6adc-456e-9411-79ff21df8544"> <state value="P" variable="T254"/> <bbox w="35.0" h="10.0" x="5532.173" y="1680.0"/> </glyph> </glyph> <glyph class="source and sink" id="s1791_sa3298" compartmentRef="c1_ca1"> <label text="s1791"/> <bbox w="30.0" h="30.0" x="5617.5" y="1650.0"/> </glyph> <glyph class="nucleic acid feature" id="s1877_sa717" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2"/> <clone/> <bbox w="76.55759" h="22.364868" x="3754.1028" y="7299.6846"/> </glyph> <glyph class="nucleic acid feature" id="s1877_sa4741" compartmentRef="c13_ca13"> <notes> <html 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merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-related protein A1 HUGO:BCL2A1 HGNC:991 ENTREZ:597 UNIPROT:Q16548 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2A1"/> <bbox w="70.0" h="25.0" x="6303.977" y="7303.7983"/> </glyph> <glyph class="nucleic acid feature" id="s1882_sa725" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:FTH1 HGNC:3976 ENTREZ:2495 UNIPROT:P02794 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="FTH1"/> <bbox w="70.0" h="25.0" x="7975.0" y="7367.5"/> </glyph> <glyph class="macromolecule" id="s1883_sa724" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:FTH1 HGNC:3976 ENTREZ:2495 UNIPROT:P02794 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:17603935 Ferritin is an iron storage protein and its concentration is inversely related to the level of Labile Iron Pool. References_end </body> </html> </notes> <label text="FTH1"/> <clone/> <bbox w="80.0" h="40.0" x="7905.8853" y="6448.246"/> </glyph> <glyph class="macromolecule" id="s1883_sa3655" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:FTH1 HGNC:3976 ENTREZ:2495 UNIPROT:P02794 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:17603935 Ferritin is an iron storage protein and its concentration is inversely related to the level of Labile Iron Pool. References_end </body> </html> </notes> <label text="FTH1"/> <clone/> <bbox w="80.0" h="40.0" x="4160.0" y="1787.0"/> </glyph> <glyph class="simple chemical" id="s1887_sa2262" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29191 CAS:3352-57-6 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="hydroxyl"/> <bbox w="70.0" h="25.0" x="8304.75" y="6627.75"/> </glyph> <glyph class="nucleic acid feature" id="s1888_sa733" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:26775703 HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. References_end </body> </html> </notes> <label text="HSP90AA1"/> <bbox w="70.0" h="25.0" x="6383.5586" y="7335.7554"/> </glyph> <glyph class="macromolecule" id="s1889_sa1161" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP90AA1"/> <bbox w="80.0" h="40.0" x="7650.0" y="5310.0"/> </glyph> <glyph class="nucleic acid feature" id="s1890_sa657" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nitric oxide synthase 2, inducible HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NOS2"/> <bbox w="70.0" h="25.0" x="5608.5" y="7312.5"/> </glyph> <glyph class="macromolecule" id="s1891_sa658" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nitric oxide synthase 2, inducible HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NOS2"/> <bbox w="80.0" h="40.0" x="10670.0" y="1420.0"/> </glyph> <glyph class="simple chemical" id="s1892_sa1207" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16467 KEGGCOMPOUND:C00062 CAS:74-79-3 Identifiers_end </body> </html> </notes> <label text="L-arginine"/> <bbox w="70.0" h="25.0" x="10809.0" y="1627.5"/> </glyph> <glyph class="simple chemical" id="s1893_sa1209" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="10800.84" y="1674.3619"/> </glyph> <glyph class="simple chemical" id="s1893_sa2299" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="7850.0" y="6625.5"/> </glyph> <glyph class="simple chemical" id="s1893_sa2310" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="10345.0" y="1397.5"/> </glyph> <glyph class="simple chemical" id="s1893_sa3253" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="6845.5" y="1575.0"/> </glyph> <glyph class="simple chemical" id="s1896_sa1208" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16349 KEGGCOMPOUND:C00327 CAS:372-75-8 Identifiers_end </body> </html> </notes> <label text="L-citrulline"/> <bbox w="70.0" h="25.0" x="10949.0" y="1677.5"/> </glyph> <glyph class="macromolecule" id="s1897_sa876" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: enolase 1, (alpha) HUGO:ENO1 HGNC:3350 ENTREZ:2023 UNIPROT:P06733 enolase 2 (gamma, neuronal) HUGO:ENO2 HGNC:3353 ENTREZ:2026 UNIPROT:P09104 enolase 3 (beta, muscle) HUGO:ENO3 HGNC:3354 ENTREZ:2027 UNIPROT:P13929 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ENO*"/> <bbox w="80.0" h="40.0" x="1349.7163" y="1993.8988"/> </glyph> <glyph class="nucleic acid feature" id="s1900_sa720" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 3 HUGO:E2F3 HGNC:3115 ENTREZ:1871 UNIPROT:O00716 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="E2F3"/> <bbox w="70.0" h="25.0" x="6231.4688" y="7307.683"/> </glyph> <glyph class="nucleic acid feature" id="s1901_sa719" compartmentRef="c13_ca13"> <label 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MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="7629.5" y="6239.25"/> <glyph class="state variable" id="_1d969bbc-df60-4c60-a97b-5a01d289d499"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="7638.095" y="6234.25"/> </glyph> <glyph class="state variable" id="_d01b717b-4356-4801-bc72-f07b8d9c89ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7681.0684" y="6234.25"/> </glyph> <glyph class="state variable" id="_b0f7412e-1181-4404-b059-96b77e8a6ac9"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="7637.001" y="6274.25"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1905_sa571" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: siah E3 ubiquitin protein ligase 1 HUGO:SIAH1 HGNC:10857 ENTREZ:6477 UNIPROT:Q8IUQ4 Identifiers_end </body> </html> </notes> <label text="SIAH1"/> <bbox w="70.0" h="25.0" x="4157.966" y="7332.848"/> </glyph> <glyph class="macromolecule" id="s1910_sa3293" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha HUGO:NFKBIA HGNC:7797 ENTREZ:4792 UNIPROT:P25963 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:I_kappa_B-_alpha_ References_end </body> </html> </notes> <label text="NFKBIA"/> <clone/> <bbox w="80.0" h="40.0" x="5574.5" y="1272.0"/> <glyph class="state variable" id="_a428fe74-d81d-42cd-a50a-8891f82e06e5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5592.9316" y="1267.0"/> </glyph> <glyph class="state variable" id="_49e40027-e998-4fac-b7f6-f28bfbbcf634"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5626.0684" y="1267.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1910_sa4945" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha HUGO:NFKBIA HGNC:7797 ENTREZ:4792 UNIPROT:P25963 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:I_kappa_B-_alpha_ References_end </body> </html> </notes> <label text="NFKBIA"/> <clone/> <bbox w="80.0" h="40.0" x="9970.0" y="5290.0"/> <glyph class="state variable" id="_36b51d1d-c7fb-4aec-831c-92c7bcc1c685"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9988.432" y="5285.0"/> </glyph> <glyph class="state variable" id="_1d424d00-4260-4e52-bec1-90bd9df5f898"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10021.568" y="5285.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1911_sa687" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS 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UNIPROT:P42229 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="STAT5A"/> <bbox w="70.0" h="25.0" x="6003.977" y="7303.7983"/> </glyph> <glyph class="macromolecule" id="s1913_sa694" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 5A HUGO:STAT5A HGNC:11366 ENTREZ:6776 UNIPROT:P42229 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:28186502 References_end </body> </html> </notes> <label text="STAT5A"/> <bbox w="80.0" h="40.0" x="6115.0" y="6920.75"/> </glyph> <glyph class="macromolecule" id="s1914_sa699" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: YY1 transcription factor HUGO:YY1 HGNC:12856 ENTREZ:7528 UNIPROT:P25490 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="YY1"/> <bbox w="80.0" h="40.0" x="6210.0" y="6920.0"/> </glyph> <glyph class="nucleic acid feature" id="s1915_sa698" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: YY1 transcription factor HUGO:YY1 HGNC:12856 ENTREZ:7528 UNIPROT:P25490 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="YY1"/> <bbox w="70.0" h="25.0" x="6079.477" y="7340.7983"/> </glyph> <glyph class="nucleic acid feature" id="s1916_sa703" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="70.0" h="25.0" x="6073.977" y="7313.7983"/> </glyph> <glyph class="nucleic acid feature" id="s1918_sa709" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CTSB"/> <bbox w="70.0" h="25.0" x="6153.0" y="7338.5"/> </glyph> <glyph class="macromolecule" id="s1919_sa710" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: synonym:cathepsins References_end </body> </html> </notes> <label text="CTSB"/> <clone/> <bbox w="80.0" h="40.0" x="8169.5" y="6283.0"/> <glyph class="state variable" id="_6a0e9407-6098-42d2-ac27-bcbb0e310c97"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8164.5" y="6298.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1919_sa3794" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: synonym:cathepsins References_end </body> </html> </notes> <label text="CTSB"/> <clone/> <bbox w="80.0" h="40.0" x="2993.0" y="2349.0"/> <glyph class="state variable" id="_bc0a5439-a2fc-4f80-b142-e01ffec40a9a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2988.0" y="2364.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s1926_sa406" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="2254.75" y="4360.25"/> </glyph> <glyph class="simple chemical" id="s1926_sa2217" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="1115.75" y="4156.25"/> </glyph> <glyph class="simple chemical" id="s1926_sa2218" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <clone/> <bbox w="70.0" h="25.0" x="1117.75" y="4055.25"/> </glyph> <glyph class="macromolecule" id="s1945_sa481" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin specific peptidase 9, X-linked HUGO:USP9X HGNC:12632 ENTREZ:8239 UNIPROT:Q93008 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="USP9X"/> <bbox w="80.0" h="40.0" x="4480.0" y="3580.0"/> </glyph> <glyph class="nucleic acid feature" id="s1946_sa490" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: insulin-like growth factor binding protein 1 HUGO:IGFBP1 HGNC:5469 ENTREZ:3484 UNIPROT:P08833 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="IGFBP1"/> <bbox w="90.0" h="25.0" x="3564.0" y="7051.5"/> <glyph class="unit of information" id="_054d7f80-fb10-47f5-bfeb-6bebd53ad25b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3599.0" y="7046.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1948_sa1164" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: egl nine homolog 1 (C. elegans) HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end References_begin: synonym:PHD2 References_end </body> </html> </notes> <label text="EGLN1"/> <bbox w="80.0" h="40.0" x="7220.0" y="5950.0"/> </glyph> <glyph class="macromolecule" id="s1952_sa509" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase7*"/> <bbox w="80.0" h="40.0" x="6940.0" y="4681.0"/> </glyph> <glyph class="nucleic acid feature" id="s1954_sa517" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="90.0" h="25.0" x="3090.0" y="7051.75"/> <glyph class="unit of information" id="_d79ca112-fc95-4aff-81ad-611cea6e96ee"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3125.0" y="7046.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1957_sa527" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: insulin-like growth factor binding protein 3 HUGO:IGFBP3 HGNC:5472 ENTREZ:3486 UNIPROT:P17936 Identifiers_end </body> </html> </notes> <label text="IGFBP3"/> <bbox w="90.0" h="25.0" x="3172.0" y="7044.75"/> <glyph class="unit of information" id="_e5a64c0c-9265-49f3-aa7d-b5a2ffe89919"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3207.0" y="7039.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1958_sa536" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sestrin 1 HUGO:SESN1 HGNC:21595 ENTREZ:27244 UNIPROT:Q9Y6P5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="SESN1"/> <bbox w="90.0" h="25.0" x="3332.0" y="7044.75"/> <glyph class="unit of information" id="_36f41b81-710c-45f3-879c-ce6cc8de95ae"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3367.0" y="7039.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1959_sa537" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sestrin 2 HUGO:SESN2 HGNC:20746 ENTREZ:83667 UNIPROT:P58004 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="SESN2"/> <bbox w="90.0" h="25.0" x="3316.0" y="7083.75"/> <glyph class="unit of information" id="_588e8d47-7843-41b4-9b64-88cddd8f9594"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3351.0" y="7078.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1960_sa546" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pleckstrin homology-like domain, family A, member 3 HUGO:PHLDA3 HGNC:8934 ENTREZ:23612 UNIPROT:Q9Y5J5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PHLDA3"/> <bbox w="90.0" h="25.0" x="3414.0" y="7051.5"/> <glyph class="unit of information" id="_1d4d3293-5398-4a97-a70e-45802ebb729b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3449.0" y="7046.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1961_sa548" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:NOXA References_end </body> </html> </notes> <label text="PMAIP1"/> <bbox w="90.0" h="25.0" x="3402.0" y="7085.5"/> <glyph class="unit of information" id="_ddfbf5ed-2417-47d2-9e73-11d25a2db679"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3437.0" y="7080.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1962_sa550" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="90.0" h="25.0" x="3494.0" y="7051.5"/> <glyph class="unit of information" id="_1a5f1a37-3504-4256-b746-0fa439bc5abf"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3529.0" y="7046.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1963_sa552" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="90.0" h="25.0" x="3474.0" y="7084.5"/> <glyph class="unit of information" id="_285e0fa6-dcbc-4eb3-a092-2d2b3fe011c3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3509.0" y="7079.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1964_sa554" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BID"/> <bbox w="90.0" h="25.0" x="3784.0" y="7051.5"/> <glyph class="unit of information" id="_5a7938b2-6e72-49b1-ad46-7ba9222e2f9f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3819.0" y="7046.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1965_sa556" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="90.0" h="25.0" x="3761.0" y="7083.5"/> <glyph class="unit of information" id="_dc6c4c8b-477e-40ec-80e9-c854ff827b52"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3796.0" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1966_sa559" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BAD"/> <bbox w="90.0" h="25.0" x="3854.0" y="7051.5"/> <glyph class="unit of information" id="_d446c807-8e9c-4b23-9796-4a6723df0c04"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3889.0" y="7046.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1967_sa561" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BAX"/> <bbox w="90.0" h="25.0" x="3834.0" y="7081.5"/> <glyph class="unit of information" id="_c1d24787-4081-4bba-bbe1-5daedea866df"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3869.0" y="7076.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1968_sa563" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:p21 synonym:CIP1 synonym:WAF1 References_end </body> </html> </notes> <label text="p21CIP1*"/> <bbox w="90.0" h="25.0" x="3927.0" y="7051.5"/> <glyph class="unit of information" id="_0763208d-bb1e-4742-a5db-e069413d9336"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3962.0" y="7046.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1970_sa567" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="90.0" h="25.0" x="3991.0" y="7079.5"/> <glyph class="unit of information" id="_e10c80d7-5011-4f61-b2a7-6493d991915a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4026.0" y="7074.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1971_sa569" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: chromosome 12 open reading frame 5 HUGO:C12orf5 HGNC:1185 ENTREZ:57103 UNIPROT:Q9NQ88 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TIGAR*"/> <bbox w="90.0" h="25.0" x="4077.0" y="7081.5"/> <glyph class="unit of information" id="_3d1cdc3a-5634-4874-9f70-920618b2e248"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4112.0" y="7076.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1972_sa507" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <clone/> <bbox w="80.0" h="40.0" x="4930.0" y="6410.0"/> <glyph class="state variable" id="_f5958da2-7eed-4762-b57f-5786d1ed8573"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4948.4316" y="6405.0"/> </glyph> <glyph class="state variable" id="_0d947a91-251e-4f5d-b80c-de2feac2a113"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4981.5684" y="6405.0"/> </glyph> <glyph class="state variable" id="_a8ce195b-20dd-4285-80e6-63917921e7dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4925.0" y="6425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1972_sa1223" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <clone/> <bbox w="80.0" h="40.0" x="9702.5" y="2262.5"/> <glyph class="state variable" id="_6ea8c37e-1c48-4243-b062-765185c3ba4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9720.932" y="2257.5"/> </glyph> <glyph class="state variable" id="_402d48f2-1dec-4b78-b41a-6584662bbe67"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9754.068" y="2257.5"/> </glyph> <glyph class="state variable" id="_839ac49a-9974-4fb3-84b2-8730cffca47a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9697.5" y="2277.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1972_sa4735" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <clone/> <bbox w="80.0" h="40.0" x="9060.0" y="6812.5"/> <glyph class="state variable" id="_f512de7d-f426-4793-8404-89be5291218d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9078.432" y="6807.5"/> </glyph> <glyph class="state variable" id="_8181b5e9-5f1a-4c9f-be2a-f9129dcbb05f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9111.568" y="6807.5"/> </glyph> <glyph class="state variable" id="_55d6fe72-7334-4920-8952-ea31a8e4a7ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9055.0" y="6827.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1973_sa573" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: siah E3 ubiquitin protein ligase 1 HUGO:SIAH1 HGNC:10857 ENTREZ:6477 UNIPROT:Q8IUQ4 Identifiers_end </body> </html> </notes> <label text="SIAH1"/> <bbox w="90.0" h="25.0" x="4151.7593" y="7080.598"/> <glyph class="unit of information" id="_9287941e-ad7c-422a-a30c-e4216ed9760b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4186.7593" y="7075.598"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1974_sa595" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <clone/> <bbox w="90.0" h="25.0" x="4710.0" y="7087.5"/> <glyph class="unit of information" id="_05ccd18f-a3c4-4c09-a7cd-029d40e3f7ee"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4745.0" y="7082.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1974_sa4737" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <clone/> <bbox w="90.0" h="25.0" x="8767.266" y="7072.5"/> <glyph class="unit of information" id="_21543ff4-c390-46bb-89e8-97fe7d3cfbda"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8802.266" y="7067.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1975_sa600" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA let-7a-1 HUGO:MIRLET7A1 HGNC:31476 ENTREZ:406881 microRNA let-7a-2 HUGO:MIRLET7A2 HGNC:31477 ENTREZ:406882 microRNA let-7a-3 HUGO:MIRLET7A3 HGNC:31478 ENTREZ:406883 Identifiers_end </body> </html> </notes> <label text="MIRLET7A*"/> <bbox w="86.0" h="25.0" x="5370.5" y="6671.0"/> <glyph class="unit of information" id="_074e1303-658b-410d-9bae-a5fb4d441088"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5398.5" y="6666.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1976_sa603" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <bbox w="90.0" h="25.0" x="5086.0" y="7056.5"/> <glyph class="unit of information" id="_6854b6f8-ecdd-4aa8-9391-f0d5d1274131"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5121.0" y="7051.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1977_sa609" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hexokinase 2 HUGO:HK2 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="HK2"/> <bbox w="90.0" h="25.0" x="5139.0" y="7086.5"/> <glyph class="unit of information" id="_106d2544-f9e3-4c63-a70c-a86532681a37"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5174.0" y="7081.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1979_sa612" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 HUGO:PFKFB3 HGNC:8874 ENTREZ:5209 UNIPROT:Q16875 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKFB3"/> <bbox w="90.0" h="25.0" x="5163.0" y="7058.5"/> <glyph class="unit of information" id="_569ccb88-b61c-46cc-9c37-dffafb104807"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5198.0" y="7053.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1980_sa783" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 HUGO:PFKFB3 HGNC:8874 ENTREZ:5209 UNIPROT:Q16875 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKFB3"/> <bbox w="80.0" h="40.0" x="1650.0" y="760.0"/> <glyph class="state variable" id="_06729dd8-f622-4d01-b762-a112eed0ff44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1668.4314" y="755.0"/> </glyph> <glyph class="state variable" id="_d7126ce6-caf0-489d-982c-4fe3ad99c41d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1701.5686" y="755.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1996_sa671" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: vascular endothelial growth factor A HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692 Identifiers_end </body> </html> </notes> <label text="VEGFA"/> <bbox w="70.0" h="25.0" x="5764.3335" y="7310.0"/> </glyph> <glyph class="simple chemical" id="s2002_sa1151" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27646922 ROS play a central role in cell signalling as well as in regulation of the main pathways ofapoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum (ER) PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. References_end </body> </html> </notes> <label text="ROS"/> <clone/> <bbox w="70.0" h="25.0" x="7655.0" y="5927.5"/> </glyph> <glyph class="simple chemical" id="s2002_sa1233" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27646922 ROS play a central role in cell signalling as well as in regulation of the main pathways ofapoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum (ER) PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. References_end </body> </html> </notes> <label text="ROS"/> <clone/> <bbox w="70.0" h="25.0" x="8785.0" y="1567.5"/> </glyph> <glyph class="simple chemical" id="s2002_sa2263" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27646922 ROS play a central role in cell signalling as well as in regulation of the main pathways ofapoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum (ER) PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. References_end </body> </html> </notes> <label text="ROS"/> <clone/> <bbox w="70.0" h="25.0" x="8178.75" y="6711.75"/> </glyph> <glyph class="simple chemical" id="s2002_sa2323" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27646922 ROS play a central role in cell signalling as well as in regulation of the main pathways ofapoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum (ER) PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. References_end </body> </html> </notes> <label text="ROS"/> <clone/> <bbox w="70.0" h="25.0" x="10017.0" y="1677.5"/> </glyph> <glyph class="simple chemical" id="s2002_sa5295" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27646922 ROS play a central role in cell signalling as well as in regulation of the main pathways ofapoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum (ER) PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. References_end </body> </html> </notes> <label text="ROS"/> <clone/> <bbox w="70.0" h="25.0" x="9025.0" y="307.5"/> </glyph> <glyph class="simple chemical" id="s2006_sa1149" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:38290 KEGGCOMPOUND:C00072 CAS:299-36-5 Identifiers_end </body> </html> </notes> <label text="L-ascorbate"/> <bbox w="70.0" h="25.0" x="7436.0" y="5883.5"/> </glyph> <glyph class="complex" id="s2010_csa100" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Fe2+:HIF1AN Identifiers_end </body> </html> </notes> <label text="FIH"/> <bbox w="100.0" h="104.0" x="6242.5" y="7723.0"/> <glyph class="macromolecule" id="s2446_sa1190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia inducible factor 1, alpha subunit inhibitor HUGO:HIF1AN HGNC:17113 ENTREZ:55662 UNIPROT:Q9NWT6 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FIH1 References_end </body> </html> </notes> <label text="HIF1AN"/> <bbox w="80.0" h="40.0" x="6252.5" y="7736.0"/> </glyph> <glyph class="simple chemical" id="s2009_sa1191"> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="6281.5" y="7781.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2014_sa1237" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="MAFK"/> <bbox w="80.0" h="40.0" x="7220.5" y="7977.0"/> </glyph> <glyph class="macromolecule" id="s2016_sa1239" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="MAFG"/> <bbox w="80.0" h="40.0" x="7322.5" y="7975.0"/> </glyph> <glyph class="macromolecule" id="s2033_sa520" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, AMP-activated, beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 protein kinase, AMP-activated, beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKA_R*"/> <bbox w="80.0" h="40.0" x="7933.48" y="2104.1501"/> </glyph> <glyph class="complex" id="s2035_csa133" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytochrome_C*:HSPB1 Identifiers_end </body> </html> </notes> <label text="CYCS:HSPB1"/> <bbox w="103.75" h="140.0" x="6503.25" y="5446.0"/> <glyph class="macromolecule" id="s2036_sa1400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock 27kDa protein 1 HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:HSP27PMID:11003656 References_end </body> </html> </notes> <label text="HSPB1"/> <bbox w="80.0" h="40.0" x="6513.75" y="5512.0"/> </glyph> <glyph class="macromolecule" id="s3470_sa2178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6511.75" y="5465.0"/> <glyph class="state variable" id="_c8ce3547-5790-4cf1-86ea-8a8ab825bc80"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6524.25" y="5460.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2039_csa66" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAB39:STK11:STRADA Identifiers_end </body> </html> </notes> <label text="CAB39:STK11:STRADA"/> <bbox w="104.0" h="156.0" x="8105.986" y="2150.1797"/> <glyph class="macromolecule" id="s2763_sa1022"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calcium binding protein 39 HUGO:CAB39 HGNC:20292 ENTREZ:51719 UNIPROT:Q9Y376 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CAB39"/> <bbox w="80.0" h="40.0" x="8117.986" y="2154.1797"/> </glyph> <glyph class="macromolecule" id="s2038_sa1023"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: STE20-related kinase adaptor alpha HUGO:STRADA HGNC:30172 ENTREZ:92335 UNIPROT:Q7RTN6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="STRADA"/> <bbox w="80.0" h="40.0" x="8117.986" y="2242.1797"/> </glyph> <glyph class="macromolecule" id="s3706_sa2702"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="8119.23" y="2196.4001"/> <glyph class="state variable" id="_541ccb74-bb1a-4d84-bcce-bfc2c57c3248"> <state value="active" variable=""/> <bbox w="40.0" h="10.0" x="8139.23" y="2191.4001"/> </glyph> <glyph class="state variable" 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MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="STRADA"/> <bbox w="80.0" h="40.0" x="1392.5" y="7025.0"/> </glyph> <glyph class="macromolecule" id="s2042_sa1361" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calcium binding protein 39 HUGO:CAB39 HGNC:20292 ENTREZ:51719 UNIPROT:Q9Y376 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CAB39"/> <bbox w="80.0" h="40.0" x="3090.0" y="6390.0"/> </glyph> <glyph class="macromolecule" id="s2044_sa1360" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="352.5" y="7115.0"/> <glyph class="state variable" id="_e2b99869-463a-4753-9f47-09413fa1b482"> <state value="?" variable="T366"/> <bbox w="35.0" h="10.0" x="358.59503" y="7110.0"/> </glyph> <glyph class="state variable" id="_13de45a8-b22e-4eef-9015-ba5bda6ec081"> <state value="Ac" variable="K48"/> <bbox w="35.0" h="10.0" x="391.56854" y="7110.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2045_sa2790" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sirtuin 1 HUGO:SIRT1 HGNC:14929 ENTREZ:23411 UNIPROT:Q96EB6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="SIRT1"/> <clone/> <bbox w="80.0" h="40.0" x="1050.0" y="3020.0"/> </glyph> <glyph class="macromolecule" id="s2045_sa4649" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sirtuin 1 HUGO:SIRT1 HGNC:14929 ENTREZ:23411 UNIPROT:Q96EB6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="SIRT1"/> <clone/> <bbox w="80.0" h="40.0" x="1845.0" y="6896.87"/> </glyph> <glyph class="complex" id="s2052_csa89" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:RHEB Identifiers_end References_begin: PMID:12906785 farnesylation References_end </body> </html> </notes> <label text="RHEB:GTP"/> <bbox w="100.0" h="94.0" x="8965.0" y="2988.0"/> <glyph class="macromolecule" id="s3615_sa1103"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Ras homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="8975.0" y="2993.0"/> <glyph class="state variable" id="_5cf59ba5-2438-4fa4-b22f-fc76f813e872"> <state value="Pr" variable=""/> <bbox w="20.0" h="10.0" x="8988.432" y="2988.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3614_sa1104"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="8980.0" y="3036.5"/> </glyph> </glyph> <glyph class="complex" id="s2054_csa92" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:RHEB Identifiers_end </body> </html> </notes> <label text="RHEB:GDP"/> <bbox w="97.0" h="94.0" x="8789.0" y="2988.0"/> <glyph class="macromolecule" id="s2049_sa1112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Ras homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="8798.667" y="2994.0"/> <glyph class="state variable" id="_bc927b78-80e7-4cdd-bc0e-c4f92f401f30"> <state value="Pr" variable=""/> <bbox w="20.0" h="10.0" x="8812.099" y="2989.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s2051_sa1113"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="8804.0" y="3036.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2075_sa1068" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8415.0" y="2945.0"/> <glyph class="state variable" id="_afd45250-0ad9-4ba9-87bd-7ff54d5bf43c"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="8454.449" y="2940.0"/> </glyph> <glyph class="state variable" id="_5ac839f8-29e8-48e1-ba70-eb83ec63ac6f"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="8423.595" y="2940.0"/> </glyph> <glyph class="state variable" id="_da55efe9-5b79-468f-aff8-96b98849ad14"> <state value="P" variable="S664"/> <bbox w="35.0" h="10.0" x="8397.5" y="2940.4395"/> </glyph> <glyph class="state variable" id="_440869ac-2778-4fdc-b66a-1c57a33d0a47"> <state value="" variable="S1345"/> <bbox w="35.0" h="10.0" x="8453.831" y="2980.0"/> </glyph> <glyph class="state variable" id="_a9906908-0bfd-4ea7-960f-a136e13b11f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8410.0" y="2960.0"/> </glyph> <glyph class="state variable" id="_b1226399-648e-407d-bfb7-9befa6352ed0"> <state value="" variable="S1798"/> <bbox w="35.0" h="10.0" x="8477.5" y="2940.5808"/> </glyph> <glyph class="state variable" id="_d9f32e75-fb68-4ff0-af07-f34b7b89c88e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8490.0" y="2980.0"/> </glyph> <glyph class="state variable" id="_36b20c95-942f-482a-b506-0258d8d7f224"> <state value="" variable="S1341"/> <bbox w="35.0" h="10.0" x="8435.176" y="2980.0"/> </glyph> <glyph class="state variable" id="_01c15668-d36d-4afc-9d19-dcc04dae3c38"> <state value="" variable="S1337"/> <bbox w="35.0" h="10.0" x="8418.219" y="2980.0"/> </glyph> <glyph class="state variable" id="_655c6524-71cc-49f1-a339-b29d5b0d6913"> <state value="?" variable="M1"/> <bbox w="25.0" h="10.0" x="8402.5" y="2979.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="s2080_sa1064" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="8095.0" y="2845.0"/> <glyph class="state variable" id="_f0cde91f-8413-4abc-b9f3-d6c237d838ce"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="8136.949" y="2840.0"/> </glyph> <glyph class="state variable" id="_a7eddc94-e344-4038-aea3-eeb0ea5d0d9d"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="8103.595" y="2840.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2086_sa1094" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PRAS References_end </body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="9063.166" y="2483.6592"/> <glyph class="state variable" id="_3afa1f7a-0c66-4f80-83d3-bb04daeeaa94"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9114.734" y="2478.6592"/> </glyph> </glyph> <glyph class="macromolecule" id="s2093_sa55" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="7662.5874" y="4838.5884"/> <glyph class="state variable" id="_49308d81-9540-4664-8fc3-27cf35bbdda1"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="7711.685" y="4833.5884"/> </glyph> </glyph> <glyph class="macromolecule" id="s2093_sa1287" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="4670.0" y="2556.0"/> <glyph class="state variable" id="_a94d7940-4ef5-4747-8a5b-990cc7c7a42d"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4719.0977" y="2551.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2093_sa1755" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="3320.0" y="2930.0"/> <glyph class="state variable" id="_8afbd76c-330b-4c6d-a86c-27306f6a440a"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3369.098" y="2925.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2093_sa3162" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="4630.0" y="1620.0"/> <glyph class="state variable" id="_760c5b20-a6a7-4186-86b0-8164fb420b3a"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4679.0977" y="1615.0"/> </glyph> </glyph> <glyph class="complex" id="s2094_csa88" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:PRAS40* Identifiers_end </body> </html> </notes> <label text="14-3-3:AKT1S1"/> <bbox w="100.0" h="120.0" x="8921.499" y="2320.326"/> <glyph class="macromolecule" id="s2092_sa1101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PRAS References_end </body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="8931.166" y="2375.6592"/> <glyph class="state variable" id="_1646ac56-eedb-4891-8f57-8c7678e9dee1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8980.234" y="2370.6592"/> </glyph> </glyph> <glyph class="macromolecule" id="s2095_sa1102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="8931.166" y="2331.6592"/> <glyph class="state variable" id="_626339ce-9495-4fa0-b376-a2317f6b42bf"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8980.264" y="2326.6592"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s2099_sa748" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end </body> </html> </notes> <label text="IKKβ*"/> <bbox w="80.0" h="40.0" x="5317.0" y="1207.0"/> <glyph class="state variable" id="_b241987c-9809-43ae-ab1d-eba35de78a10"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5335.4316" y="1202.0"/> </glyph> <glyph class="state variable" id="_4b233737-735a-471c-a307-0437ac816ec7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5368.5684" y="1202.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2101_sa1129" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase, 70kDa, polypeptide 1 HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 ribosomal protein S6 kinase, 70kDa, polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:S6K1 synonym:S6K2 References_end </body> </html> </notes> <label text="S6K*"/> <bbox w="80.0" h="40.0" x="9379.0" y="3127.0"/> <glyph class="state variable" id="_21816f37-6e6c-44e6-8518-9f3d92040b41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9430.568" y="3122.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2105_sa1090" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="8766.5" y="2279.5"/> <glyph class="state variable" id="_e50ac846-8ff4-4d05-8497-a7ff7039740e"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="8805.949" y="2274.5"/> </glyph> <glyph class="state variable" id="_d8df9fd1-1055-4598-b936-ce3b00aacbf8"> <state value="P" variable="S722"/> <bbox w="35.0" h="10.0" x="8772.595" y="2274.5"/> </glyph> <glyph class="state variable" id="_9c0fbb8a-f09c-4755-acb7-907aa002848c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8784.932" y="2314.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2106_sa1125" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4E binding protein 1 HUGO:EIF4EBP1 HGNC:3288 ENTREZ:1978 UNIPROT:Q13541 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:25682865 Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells References_end </body> </html> </notes> <label text="4E-BP*"/> <bbox w="80.0" h="40.0" x="9815.0" y="3135.0"/> <glyph class="state variable" id="_9840284c-6895-4953-a530-85aa960c07fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9866.568" y="3130.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2107_sa1124" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4E binding protein 1 HUGO:EIF4EBP1 HGNC:3288 ENTREZ:1978 UNIPROT:Q13541 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:25682865 Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells References_end </body> </html> </notes> <label text="4E-BP*"/> <bbox w="80.0" h="40.0" x="9986.0" y="3136.0"/> <glyph class="state variable" id="_52e94bcc-32ff-4e11-a8fb-9f0c9237d1c9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10035.068" y="3131.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2108_sa1092" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9286.499" y="1629.3258"/> </glyph> <glyph class="macromolecule" id="s2109_sa1093" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:27754749 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="9286.499" y="1679.3258"/> </glyph> <glyph class="macromolecule" id="s2110_sa1091" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="8765.0" y="2395.0"/> <glyph class="state variable" id="_43adadf7-362e-4d41-b2db-f1520bd057d4"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="8806.949" y="2390.0"/> </glyph> <glyph class="state variable" id="_ac08c87d-de97-49a9-bada-46c7be03bc43"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="8773.595" y="2390.0"/> </glyph> <glyph class="state variable" id="_714b8201-ce80-4715-ad56-05f0a8cebf5b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8783.432" y="2430.0"/> </glyph> </glyph> <glyph class="complex" id="s2111_csa86" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:RPTOR Identifiers_end </body> </html> </notes> <label text="14-3-3:RPTOR"/> <bbox w="100.0" h="120.0" x="8598.999" y="1926.3258"/> <glyph class="macromolecule" id="s2113_sa1096"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="8608.499" y="1981.3258"/> <glyph class="state variable" id="_c4965d35-02dc-47f8-bc12-dac5e32b9cae"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="8647.948" y="1976.3258"/> </glyph> <glyph class="state variable" id="_7c11b174-6117-4026-8961-35843c854c68"> <state value="P" variable="S722"/> <bbox w="35.0" h="10.0" x="8614.594" y="1976.3258"/> </glyph> <glyph class="state variable" id="_ec2e3bd3-dc30-404e-ad88-6190d5154858"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8626.931" y="2016.3258"/> </glyph> </glyph> <glyph class="macromolecule" id="s2112_sa1097"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="8607.999" y="1937.3258"/> <glyph class="state variable" id="_7ca5e7e2-29ce-4c81-9182-7cf7015f255f"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8657.097" y="1932.3258"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s2114_sa1126" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4E HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="EIF4E"/> <bbox w="80.0" h="40.0" x="9689.0" y="3135.0"/> </glyph> <glyph class="complex" id="s2115_csa95" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:4E-BP*:EIF4E Identifiers_end </body> </html> </notes> <label text="EIF4E:EIF4EBP1"/> <bbox w="100.0" h="120.0" x="9735.0" y="2985.0"/> <glyph class="macromolecule" id="s2117_sa1132"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 4E binding protein 1 HUGO:EIF4EBP1 HGNC:3288 ENTREZ:1978 UNIPROT:Q13541 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:25682865 Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells References_end </body> </html> </notes> <label text="4E-BP*"/> <bbox w="80.0" h="40.0" x="9746.0" y="3040.0"/> <glyph class="state variable" id="_ac3c7205-0319-4f4b-afe7-8a4b70c5b214"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9797.568" y="3035.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2116_sa1133"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 4E HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="EIF4E"/> <bbox w="80.0" h="40.0" x="9746.0" y="2996.0"/> </glyph> </glyph> <glyph class="phenotype" id="s2118_sa1130" compartmentRef="c1_ca1"> <label text="Capped RNA translation"/> <bbox w="176.0" h="32.0" x="9647.0" y="3329.0"/> </glyph> <glyph class="nucleic acid feature" id="s2122_sa663" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO3"/> <bbox w="70.0" h="25.0" x="5684.3335" y="7310.0"/> </glyph> <glyph class="macromolecule" id="s2123_sa664" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5950.0" y="6920.0"/> </glyph> <glyph class="macromolecule" id="s2125_sa1197" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 HUGO:CITED2 HGNC:1987 ENTREZ:10370 UNIPROT:Q99967 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CITED2"/> <bbox w="80.0" h="40.0" x="6102.5" y="7725.0"/> </glyph> <glyph class="nucleic acid feature" id="s2126_sa1203" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 HUGO:CITED2 HGNC:1987 ENTREZ:10370 UNIPROT:Q99967 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CITED2"/> <bbox w="70.0" h="25.0" x="4573.0" y="7318.5"/> </glyph> <glyph class="macromolecule" id="s2135_sa1131" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4B HUGO:EIF4B HGNC:3285 ENTREZ:1975 UNIPROT:P23588 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="EIF4B"/> <bbox w="80.0" h="40.0" x="9336.0" y="3264.0"/> <glyph class="state variable" id="_843ab22c-1540-4357-9607-6070aa801db4"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="9382.376" y="3259.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2136_sa1128" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4B HUGO:EIF4B HGNC:3285 ENTREZ:1975 UNIPROT:P23588 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="EIF4B"/> <bbox w="80.0" h="40.0" x="9489.0" y="3263.0"/> <glyph class="state variable" id="_3c8d5e31-9846-4c5d-ab8e-357916c0aa49"> <state value="P" variable="S422"/> <bbox w="35.0" h="10.0" x="9532.876" y="3258.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2137_sa1127" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase, 70kDa, polypeptide 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<title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA-damage-inducible transcript 4 HUGO:DDIT4 HGNC:24944 ENTREZ:54541 UNIPROT:Q9NX09 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:REDD1 synonym:RTP801 References_end </body> </html> </notes> <label text="DDIT4"/> <bbox w="70.0" h="25.0" x="5768.5" y="7342.5"/> </glyph> <glyph class="macromolecule" id="s2147_sa669" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA-damage-inducible transcript 4 HUGO:DDIT4 HGNC:24944 ENTREZ:54541 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x="8561.98" y="2925.4001"/> <glyph class="macromolecule" id="s2150_sa1084"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8575.0" y="2995.0"/> <glyph class="state variable" id="_cabf9b05-3616-433c-9acd-e3bbce5f0515"> <state value="*" variable="T1462"/> <bbox w="40.0" h="10.0" x="8611.949" y="2990.0"/> </glyph> <glyph class="state variable" id="_886a3364-61b6-4dc1-82cd-5823d2cc1d67"> <state value="*" variable="S939"/> <bbox w="35.0" h="10.0" x="8581.095" y="2990.0"/> </glyph> <glyph class="state variable" id="_85561dd1-9edd-4741-b74f-e6a6100d9fc0"> <state value="" 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Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23377657 PMID:17446862 PMID:27754749 References_end </body> </html> </notes> <label text="BECN1"/> <bbox w="80.0" h="40.0" x="9922.5" y="2372.5"/> <glyph class="state variable" id="_19d2faed-1bf1-4d4d-b668-6c903d1a702c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9917.5" y="2367.5"/> </glyph> <glyph class="state variable" id="_95e8880f-118f-41bf-a705-c595c99f92b2"> <state value="" variable="T119"/> <bbox w="30.0" h="10.0" x="9964.449" y="2367.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2160_sa745" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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<body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8099.48" y="2761.4001"/> <glyph class="state variable" id="_fe1ef09e-db94-46d2-90cc-65b9a61ada7a"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="8138.929" y="2756.4001"/> </glyph> <glyph class="state variable" id="_33e58cc4-6d13-4b25-8f7d-00d554b60c6b"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="8108.075" y="2756.4001"/> </glyph> <glyph class="state variable" id="_52e5447c-4015-479c-8eab-47af4278fa00"> <state value="" variable="S664"/> <bbox w="30.0" h="10.0" x="8084.48" y="2756.8396"/> </glyph> <glyph class="state variable" 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<title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: vesicle-associated membrane protein 2 (synaptobrevin 2) HUGO:VAMP2 HGNC:12643 ENTREZ:6844 UNIPROT:P63027 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="VAMP2"/> <bbox w="80.0" h="40.0" x="410.0" y="400.0"/> </glyph> <glyph class="complex" id="s2210_csa128" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SNAP23:STX4:STXBP4 Identifiers_end </body> </html> </notes> <label text="SNAP23:STX4:STXBP4"/> <bbox w="110.0" h="171.0" x="292.5" y="145.0"/> <glyph class="macromolecule" id="s2200_sa1351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: syntaxin binding protein 4 HUGO:STXBP4 HGNC:19694 ENTREZ:252983 UNIPROT:Q6ZWJ1 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="STXBP4"/> <bbox w="80.0" h="40.0" x="310.0" y="250.0"/> <glyph class="state variable" id="_1c0c9512-cde8-4d9c-aa3a-1bc3fdea185d"> <state value="" variable="S99"/> <bbox w="25.0" h="10.0" x="354.44928" y="245.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2202_sa1352"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: syntaxin 4 HUGO:STX4 HGNC:11439 ENTREZ:6810 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 1 HUGO:SLC2A1 HGNC:11005 ENTREZ:6513 UNIPROT:P11166 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT1 References_end </body> </html> </notes> <label text="SLC2A1"/> <bbox w="80.0" h="40.0" x="800.0" y="340.0"/> </glyph> <glyph class="simple chemical" id="s2218_sa1017" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end 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id="s2329_sa627" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 HUGO:PFKFB4 HGNC:8875 ENTREZ:5210 UNIPROT:Q16877 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PFKFB4"/> <bbox w="90.0" h="25.0" x="5303.0" y="7058.5"/> <glyph class="unit of information" id="_67968138-023a-4512-aa5d-738ce3980bda"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5338.0" y="7053.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2330_sa630" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase A, fructose-bisphosphate HUGO:ALDOA HGNC:414 ENTREZ:226 UNIPROT:P04075 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ALDOA"/> <bbox w="90.0" h="25.0" x="5359.0" y="7094.5"/> <glyph class="unit of information" id="_8f48163a-b7e8-4c5e-9aeb-dbc4ea865ac3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5394.0" y="7089.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2331_sa633" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucose-6-phosphate isomerase HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GPI"/> <bbox w="90.0" h="25.0" x="5382.0" y="7061.5"/> <glyph class="unit of information" id="_ac5e8dd7-7528-49b4-8aef-20416ca22afd"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5417.0" y="7056.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2332_sa636" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 1 HUGO:SLC2A1 HGNC:11005 ENTREZ:6513 UNIPROT:P11166 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT1 References_end </body> </html> </notes> <label text="SLC2A1"/> <bbox w="90.0" h="25.0" x="5433.0" y="7088.5"/> <glyph class="unit of information" id="_5f1a808f-2c7a-4fcf-ba9b-2948e7dd1867"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5468.0" y="7083.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2333_sa639" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:9021 Identifiers_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate kinase, muscle HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618 Identifiers_end </body> </html> </notes> <label text="PKM2"/> <bbox w="90.0" h="25.0" x="5452.0" y="7061.5"/> <glyph class="unit of information" id="_a6b637ca-9786-43d7-8b4e-2970555bd658"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5487.0" y="7056.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2334_sa642" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:12009 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: triosephosphate isomerase 1 HUGO:TPI1 HGNC:12009 ENTREZ:7167 UNIPROT:P60174 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="TPI1"/> <bbox w="90.0" h="25.0" x="5507.0" y="7090.5"/> <glyph class="unit of information" id="_642b0297-ee45-4e4f-ac6e-90021535897d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5542.0" y="7085.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2335_sa647" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:1084 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2/adenovirus E1B 19kDa interacting protein 3 HUGO:BNIP3 HGNC:1084 ENTREZ:664 UNIPROT:Q12983 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="BNIP3"/> <bbox w="90.0" h="25.0" x="5522.0" y="7061.5"/> <glyph class="unit of information" id="_1462a808-0f32-476f-9c8c-befab88a1029"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5557.0" y="7056.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2336_sa650" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:8896 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglycerate kinase 1 HUGO:PGK1 HGNC:8896 ENTREZ:5230 UNIPROT:P00558 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PGK1"/> <bbox w="90.0" h="25.0" x="5665.0" y="7089.5"/> <glyph class="unit of information" id="_b285f331-2299-4fd7-ac63-f8901244a4b0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5700.0" y="7084.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2337_sa653" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:1383 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: carbonic anhydrase IX HUGO:CA9 HGNC:1383 ENTREZ:768 UNIPROT:Q16790 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CA9"/> <bbox w="90.0" h="25.0" x="5592.0" y="7091.5"/> <glyph class="unit of information" id="_73c8b2c4-4002-46a6-a277-0905e11c3475"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5627.0" y="7086.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2338_sa655" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 3 HUGO:PDK3 HGNC:8811 ENTREZ:5165 UNIPROT:Q15120 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDK3"/> <bbox w="80.0" h="40.0" x="5690.0" y="6930.0"/> </glyph> <glyph class="nucleic acid feature" id="s2339_sa656" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:8811 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 3 HUGO:PDK3 HGNC:8811 ENTREZ:5165 UNIPROT:Q15120 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDK3"/> <bbox w="90.0" h="25.0" x="5595.0" y="7059.5"/> <glyph class="unit of information" id="_38993d21-187e-4280-a492-0b85570fd58f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5630.0" y="7054.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2340_sa659" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:7873 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nitric oxide synthase 2, inducible HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NOS2"/> <bbox w="90.0" h="25.0" x="5677.0" y="7057.5"/> <glyph class="unit of information" id="_b24983de-1264-45be-a700-ac319d6a1958"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5712.0" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2341_sa662" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:992 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="90.0" h="25.0" x="5738.0" y="7086.5"/> <glyph class="unit of information" id="_7507f87b-891c-40b8-8742-9195ea2724ae"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5773.0" y="7081.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2343_sa666" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:3821 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO3"/> <bbox w="90.0" h="25.0" x="5747.0" y="7057.5"/> <glyph class="unit of information" id="_10123ec9-09db-482f-9184-8ce3520c6f5c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5782.0" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2345_sa670" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:24944 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:REDD1 synonym:RTP801 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA-damage-inducible transcript 4 HUGO:DDIT4 HGNC:24944 ENTREZ:54541 UNIPROT:Q9NX09 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="DDIT4"/> <bbox w="90.0" h="25.0" x="5810.0" y="7085.5"/> <glyph class="unit of information" id="_ae0f89d7-e790-4f1b-88d6-755ca1c83a82"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5845.0" y="7080.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2347_sa675" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: vascular endothelial growth factor A HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692 Identifiers_end </body> </html> </notes> <label text="VEGFA"/> <bbox w="80.0" h="40.0" x="5750.0" y="8170.0"/> </glyph> <glyph class="nucleic acid feature" id="s2348_sa676" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:12680 Identifiers_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: vascular endothelial growth factor A HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692 Identifiers_end </body> </html> </notes> <label text="VEGFA"/> <bbox w="90.0" h="25.0" x="5817.0" y="7057.5"/> <glyph class="unit of information" id="_2d0d47f2-c724-4512-8703-81aea670b857"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5852.0" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2351_sa682" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:1232 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end References_begin: synonym:PHD2 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: egl nine homolog 1 (C. elegans) HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="EGLN1"/> <bbox w="90.0" h="25.0" x="5893.5" y="7087.5"/> <glyph class="unit of information" id="_eeb74e67-88f8-4608-a956-6c1e3c43ad5f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5928.5" y="7082.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2352_sa683" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: egl nine homolog 2 (C. elegans) HUGO:EGLN2 HGNC:14660 ENTREZ:112398 UNIPROT:Q96KS0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="EGLN2"/> <bbox w="90.0" h="25.0" x="5973.5" y="7091.5"/> <glyph class="unit of information" id="_6a154e9f-03f5-46ef-a66e-20764fcbbff3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6008.5" y="7086.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2356_sa691" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha HUGO:NFKBIA HGNC:7797 ENTREZ:4792 UNIPROT:P25963 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:IkappaBalpha References_end </body> </html> </notes> <label text="NFKBIA"/> <bbox w="90.0" h="25.0" x="6043.5" y="7090.5"/> <glyph class="unit of information" id="_00395554-5cb8-4880-a4c4-bd3e44b92f24"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6078.5" y="7085.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2357_sa697" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 5A HUGO:STAT5A HGNC:11366 ENTREZ:6776 UNIPROT:P42229 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="STAT5A"/> <bbox w="90.0" h="25.0" x="6063.5" y="7057.5"/> <glyph class="unit of information" id="_aa8b39ed-d97b-44a3-ae26-f7e999ae97ef"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6098.5" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2359_sa706" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="90.0" h="25.0" x="6133.5" y="7057.5"/> <glyph class="unit of information" id="_84d5d0c4-2cb5-462b-b228-b47a6670170b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6168.5" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2361_sa712" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CTSB"/> <bbox w="90.0" h="25.0" x="6188.5" y="7089.5"/> <glyph class="unit of information" id="_5bf176f9-7125-4962-8ced-39ff281713f9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6223.5" y="7084.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2362_sa716" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 3 HUGO:BIRC3 HGNC:591 ENTREZ:330 UNIPROT:Q13489 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="BIRC3"/> <bbox w="90.0" h="25.0" x="6203.5" y="7057.5"/> <glyph class="unit of information" id="_40a9d94f-e622-441f-bcb5-fc52e6536358"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6238.5" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2363_sa721" compartmentRef="c13_ca13"> <label text="E2F3B*"/> <bbox w="90.0" h="25.0" x="6273.5" y="7057.5"/> <glyph class="unit of information" id="_3d9baa2a-6282-4da3-98c0-a91753096158"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6308.5" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2365_sa727" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:FTH1 HGNC:3976 ENTREZ:2495 UNIPROT:P02794 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="FTH1"/> <bbox w="90.0" h="25.0" x="7965.0" y="7257.5"/> <glyph class="unit of information" id="_4d66a7e2-b050-4114-8a4e-cec9f77c27d3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8000.0" y="7252.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2366_sa731" compartmentRef="c13_ca13"> <notes> <html 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:26775703 HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. References_end </body> </html> </notes> <label text="HSP90AA1"/> <bbox w="90.0" h="25.0" x="6462.5" y="7087.5"/> <glyph class="unit of information" id="_b8fae740-1a58-4a85-b8ce-854eef44189b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6497.5" y="7082.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2369_sa736" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="70.0" h="25.0" x="6383.977" y="7303.7983"/> </glyph> <glyph class="nucleic acid feature" id="s2370_sa738" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:26775703 HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. References_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="90.0" h="25.0" x="6483.5" y="7057.5"/> <glyph class="unit of information" id="_d86f2e92-5e25-4600-8ea7-4ac7c763b1b7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6518.5" y="7052.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2371_sa739" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor, alpha-induced protein 3 HUGO:TNFAIP3 HGNC:11896 ENTREZ:7128 UNIPROT:P21580 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:A20 References_end </body> </html> </notes> <label text="TNFAIP3"/> <bbox w="70.0" h="25.0" x="6463.977" y="7333.7983"/> </glyph> <glyph class="macromolecule" id="s2372_sa3216" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor, alpha-induced protein 3 HUGO:TNFAIP3 HGNC:11896 ENTREZ:7128 UNIPROT:P21580 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: synonym:A20 PMID:20599425 References_end </body> </html> </notes> <label text="TNFAIP3"/> <clone/> <bbox w="80.0" h="40.0" x="4400.0" y="890.0"/> </glyph> <glyph class="macromolecule" id="s2372_sa3955" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor, alpha-induced protein 3 HUGO:TNFAIP3 HGNC:11896 ENTREZ:7128 UNIPROT:P21580 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: synonym:A20 PMID:20599425 References_end </body> </html> </notes> <label text="TNFAIP3"/> <clone/> <bbox w="80.0" h="40.0" x="7300.0" y="400.0"/> </glyph> <glyph class="nucleic acid feature" id="s2373_sa741" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor, alpha-induced protein 3 HUGO:TNFAIP3 HGNC:11896 ENTREZ:7128 UNIPROT:P21580 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:A20 References_end </body> </html> </notes> <label text="TNFAIP3"/> <bbox w="90.0" h="25.0" x="6533.5" y="7087.5"/> <glyph class="unit of information" id="_5e483cc8-6a3e-4065-8613-c64aaec25d9e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6568.5" y="7082.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2374_sa744" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BECN1"/> <bbox w="90.0" h="25.0" x="6555.5" y="7060.5"/> <glyph class="unit of information" id="_e8e9bcd5-53ce-42a1-98b9-a25f530d996e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6590.5" y="7055.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2375_sa747" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: superoxide dismutase 2, mitochondrial HUGO:SOD2 HGNC:11180 ENTREZ:6648 UNIPROT:P04179 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SOD2"/> <bbox w="90.0" h="25.0" x="6601.5" y="7096.5"/> <glyph class="unit of information" id="_fa624a38-3949-49a8-932a-faa62620b281"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6636.5" y="7091.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2376_sa749" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: superoxide dismutase 1, soluble HUGO:SOD1 HGNC:11179 ENTREZ:6647 UNIPROT:P00441 Identifiers_end Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SOD1"/> <bbox w="70.0" h="25.0" x="6543.326" y="7306.82"/> </glyph> <glyph class="nucleic acid feature" id="s2377_sa750" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: superoxide dismutase 1, soluble HUGO:SOD1 HGNC:11179 ENTREZ:6647 UNIPROT:P00441 Identifiers_end Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SOD1"/> <bbox w="90.0" h="25.0" x="6623.5" y="7067.5"/> <glyph class="unit of information" id="_bf1feb41-e01d-427c-82be-ee878227e3a0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6658.5" y="7062.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2378_sa752" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: superoxide dismutase 1, soluble HUGO:SOD1 HGNC:11179 ENTREZ:6647 UNIPROT:P00441 Identifiers_end 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:p21 synonym:CIP1 synonym:WAF1 References_end </body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="3810.0" y="6495.0"/> </glyph> <glyph class="nucleic acid feature" id="s2381_sa755" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 133a-1 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Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="1183.75" y="3375.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa2272" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. 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Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="6115.0" y="5917.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa3091" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="6435.0" y="5787.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa3247" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="6005.0" y="337.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa3250" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="6205.0" y="457.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa3702" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="2627.5" y="1982.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa4884" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="9485.0" y="6187.5"/> </glyph> <glyph class="simple chemical" id="s2398_sa5322" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. 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<head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: G0/G1switch 2 HUGO:G0S2 HGNC:30229 ENTREZ:50486 UNIPROT:P27469 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="G0S2"/> <bbox w="80.0" h="40.0" x="4390.0" y="3570.0"/> </glyph> <glyph class="nucleic acid feature" id="s2414_sa980" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end </body> </html> </notes> <label text="FASL*"/> <bbox w="70.0" h="25.0" x="4566.845" y="7356.726"/> </glyph> <glyph class="nucleic acid feature" id="s2415_sa981" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end </body> </html> </notes> <label text="FASL*"/> <bbox w="90.0" h="25.0" x="4570.0" y="7092.5"/> <glyph class="unit of information" id="_77005dfa-e640-4814-bc0a-1ddfc6d3fae3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4605.0" y="7087.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2417_sa1005" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="7990.0" y="1850.0"/> <glyph class="state variable" id="_3b85234b-6a5f-4172-b92a-7adc1be42f1f"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="8001.335" y="1845.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2418_sa1010" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 References_end </body> </html> </notes> <label text="FOXO*"/> <bbox w="80.0" h="40.0" x="8339.0" y="1783.0"/> <glyph class="state variable" id="_2c656516-ff50-483b-8001-46c52155cc42"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8388.188" y="1778.0"/> </glyph> <glyph class="state variable" id="_79011e8a-8fd7-4a78-838d-0847f360e3c0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8354.932" y="1778.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2419_sa1011" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 References_end </body> </html> </notes> <label text="FOXO*"/> <bbox w="80.0" h="40.0" x="8496.606" y="1783.8634"/> <glyph class="state variable" id="_d35cb056-c9f3-4b41-b1b9-a0945e268ae0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8548.295" y="1778.8634"/> </glyph> <glyph class="state variable" id="_de4fd61a-f318-46b2-b64a-5dfd6a36f3d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8515.038" y="1778.8634"/> </glyph> </glyph> <glyph class="complex" id="s2421_csa67" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMP:PKA_R*:PRKAA*:PRKAG* Identifiers_end References_begin: PMID:12208500 PMID:23030059 PMID:12546687 PMID:19037093 References_end </body> </html> </notes> <label text="AMPK"/> <bbox w="176.0" h="112.0" x="8380.0" y="2405.5"/> <glyph class="simple chemical" id="s2020_sa1024"> <label text="AMP"/> <bbox w="70.0" h="25.0" x="8475.0" y="2465.0"/> </glyph> <glyph class="macromolecule" id="s2030_sa1025"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, alpha 1 catalytic subunit HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 protein kinase, AMP-activated, alpha 2 catalytic subunit HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAA*"/> <bbox w="80.0" h="40.0" x="8386.0" y="2411.5"/> <glyph class="state variable" id="_bb397b41-0e0f-4cbe-ac20-72ce5172613b"> <state value="P" variable="T172"/> <bbox w="35.0" h="10.0" x="8425.449" y="2406.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2168_sa1026"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 protein kinase, AMP-activated, beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKA_R*"/> <bbox w="80.0" h="40.0" x="8386.0" y="2455.5"/> </glyph> <glyph class="macromolecule" id="s2034_sa1027"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 protein kinase, AMP-activated, gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 protein kinase, AMP-activated, gamma 3 non-catalytic subunit HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAG*"/> <bbox w="80.0" h="40.0" x="8470.0" y="2411.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2422_sa1136" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SIVA1, apoptosis-inducing factor HUGO:SIVA1 HGNC:17712 ENTREZ:10572 UNIPROT:O15304 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="SIVA1"/> <bbox w="70.0" h="25.0" x="4242.5" y="7339.0"/> </glyph> <glyph class="nucleic acid feature" id="s2423_sa1138" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SIVA1, apoptosis-inducing factor HUGO:SIVA1 HGNC:17712 ENTREZ:10572 UNIPROT:O15304 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="SIVA1"/> <bbox w="90.0" h="25.0" x="4223.0" y="7082.5"/> <glyph class="unit of information" id="_98924aa8-3df2-42cf-b42f-6d09b23dbf7e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4258.0" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2424_sa1139" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 5A HUGO:STAT5A HGNC:11366 ENTREZ:6776 UNIPROT:P42229 signal transducer and activator of transcription 5B HUGO:STAT5B HGNC:11367 ENTREZ:6777 UNIPROT:P51692 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:28186502 References_end </body> </html> </notes> <label text="STAT5*"/> <bbox w="80.0" h="40.0" x="5715.0" y="7425.0"/> </glyph> <glyph class="source and sink" id="s2427_sa1153" compartmentRef="c1_ca1"> <label text="s1956"/> <bbox w="30.0" h="30.0" x="7162.5" y="6244.0"/> </glyph> <glyph class="macromolecule" id="s2428_sa1155" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="7267.5" y="6239.25"/> <glyph class="state variable" id="_a322eb76-72c1-44fb-9358-1de08c0f8478"> <state value="OH" variable="P564"/> <bbox w="40.0" h="10.0" x="7271.095" y="6234.25"/> </glyph> <glyph class="state variable" id="_6a3f27a4-86e5-4a4f-8d53-d818e111f276"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7314.0684" y="6234.25"/> </glyph> <glyph class="state variable" id="_66c7d636-ed19-490a-9f02-ed24cb5319cd"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="7275.001" y="6274.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s2429_sa1156" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="7424.708" y="6240.3804"/> <glyph class="state variable" id="_4b45e1ba-15f5-4f6b-ab52-0df93a94f784"> <state value="OH" variable="P564"/> <bbox w="40.0" h="10.0" x="7428.303" y="6235.3804"/> </glyph> <glyph class="state variable" id="_2cd1ab41-f1cb-4e9f-9d3f-2501f0ebe053"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7476.2764" y="6235.3804"/> </glyph> <glyph class="state variable" id="_128a6fa7-0172-4dfe-bc88-26746dbe441d"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="7432.209" y="6275.3804"/> </glyph> </glyph> <glyph class="simple chemical" id="s2430_sa1163" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37154 Identifiers_end </body> </html> </notes> <label text="fumarate"/> <bbox w="70.0" h="25.0" x="7542.5" y="6366.75"/> </glyph> <glyph class="macromolecule" id="s2431_sa1165" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: egl nine homolog 2 (C. elegans) HUGO:EGLN2 HGNC:14660 ENTREZ:112398 UNIPROT:Q96KS0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end References_begin: synonym:PHD1 References_end </body> </html> </notes> <label text="EGLN2"/> <bbox w="80.0" h="40.0" x="7210.0" y="6010.0"/> </glyph> <glyph class="complex" id="s2432_csa96" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL Identifiers_end </body> </html> </notes> <label text="HIF1A_E3 ligase"/> <bbox w="260.0" h="124.0" x="7240.0" y="6458.0"/> <glyph class="simple chemical" id="s7427_sa1159"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end </body> </html> </notes> <label text="O2"/> <bbox w="70.0" h="25.0" x="7327.0" y="6482.25"/> </glyph> <glyph class="simple chemical" id="s7428_sa1162"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:16810 KEGGCOMPOUND:C00026 CAS:64-15-3 Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end </body> </html> </notes> <label text="2-oxoglutarate"/> <bbox w="70.0" h="25.0" x="7295.0" y="6522.25"/> </glyph> <glyph class="macromolecule" id="s1939_sa1167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase HUGO:VHL HGNC:12687 ENTREZ:7428 UNIPROT:P40337 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="VHL"/> <bbox w="80.0" h="40.0" x="7246.0" y="6466.0"/> </glyph> <glyph class="macromolecule" id="s1942_sa1168"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="7413.0" y="6467.0"/> </glyph> <glyph class="macromolecule" id="s2483_sa1169"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 2 HUGO:CUL2 HGNC:2552 ENTREZ:8453 UNIPROT:Q13617 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CUL2"/> <bbox w="80.0" h="40.0" x="7247.0" y="6511.0"/> </glyph> <glyph class="macromolecule" id="s1943_sa1170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) HUGO:TCEB1 HGNC:11617 ENTREZ:6921 UNIPROT:Q15369 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: subunit C References_end </body> </html> </notes> <label text="TCEB1"/> <bbox w="80.0" h="40.0" x="7330.0" y="6467.0"/> </glyph> <glyph class="macromolecule" id="s1944_sa1171"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) HUGO:TCEB2 HGNC:11619 ENTREZ:6923 UNIPROT:Q15370 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: subunit B References_end </body> </html> </notes> <label text="TCEB2"/> <bbox w="80.0" h="40.0" x="7332.0" y="6511.0"/> </glyph> <glyph class="macromolecule" id="s2237_sa1172"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:RACK1 References_end </body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7415.0" y="6511.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2442_sa1182" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aryl hydrocarbon receptor nuclear translocator HUGO:ARNT HGNC:700 ENTREZ:405 UNIPROT:P27540 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:HIF1beta References_end </body> </html> </notes> <label text="HIF1B*"/> <bbox w="80.0" h="40.0" x="6042.5" y="7655.0"/> </glyph> <glyph class="complex" id="s2451_csa102" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HIF1A:HIF1B*:p300* Identifiers_end </body> </html> </notes> <label text="ARNT:HIF1:EP300"/> <bbox w="100.0" h="176.0" x="5642.5" y="7567.0"/> <glyph class="macromolecule" id="s2454_sa1194"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="5650.0" y="7675.0"/> <glyph class="state variable" id="_c6b800ab-f1c1-4eb3-bed8-9616ce830d56"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="5699.0684" y="7670.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2453_sa1195"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aryl hydrocarbon receptor nuclear translocator HUGO:ARNT HGNC:700 ENTREZ:405 UNIPROT:P27540 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:HIF1beta References_end </body> </html> </notes> <label text="HIF1B*"/> <bbox w="80.0" h="40.0" x="5650.0" y="7575.0"/> </glyph> <glyph class="macromolecule" id="s2452_sa1196"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="5649.7666" y="7624.368"/> <glyph class="state variable" id="_9c880122-4922-4856-aea3-c40cf48fc362"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="5658.362" y="7619.368"/> </glyph> <glyph class="state variable" id="_ece66d47-40a9-495c-a84d-88c523c907e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5701.335" y="7619.368"/> </glyph> <glyph class="state variable" id="_97bd13a1-b83b-4777-b9a8-cc3e26d34f51"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="5657.2676" y="7659.368"/> </glyph> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2455_sa1205" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 HUGO:CITED2 HGNC:1987 ENTREZ:10370 UNIPROT:Q99967 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CITED2"/> <bbox w="90.0" h="25.0" x="4653.0" y="7058.5"/> <glyph class="unit of information" id="_7cf59c8d-ea7e-4b4d-bdb3-9ce874a9f636"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4688.0" y="7053.5"/> </glyph> </glyph> <glyph class="complex" id="s2456_csa105" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ENOS*:FAD:FMN:heme b:tetrahydrobiopterin Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NOS2"/> <bbox w="199.0" h="117.0" x="10824.0" y="1483.0"/> <glyph class="simple chemical" id="s536_sa1212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:26355 KEGGCOMPOUND:C00032 CAS:14875-96-8 </body> </html> </notes> <label text="heme b"/> <bbox w="70.0" h="25.0" x="10829.0" y="1557.5"/> </glyph> <glyph class="macromolecule" id="s2458_sa1213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nitric oxide synthase 1 (neuronal) HUGO:NOS1 HGNC:7872 ENTREZ:4842 UNIPROT:P29475 nitric oxide synthase 2, inducible HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 nitric oxide synthase 3 (endothelial cell) HUGO:NOS3 HGNC:7876 ENTREZ:4846 UNIPROT:P29474 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="ENOS*"/> <bbox w="80.0" h="40.0" x="10834.0" y="1490.0"/> </glyph> <glyph class="macromolecule" id="s2458_sa1214"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nitric oxide synthase 1 (neuronal) HUGO:NOS1 HGNC:7872 ENTREZ:4842 UNIPROT:P29475 nitric oxide synthase 2, inducible HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 nitric oxide synthase 3 (endothelial cell) HUGO:NOS3 HGNC:7876 ENTREZ:4846 UNIPROT:P29474 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="ENOS*"/> <bbox w="80.0" h="40.0" x="10844.0" y="1500.0"/> </glyph> <glyph class="simple chemical" id="s2460_sa1215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="10949.0" y="1490.0"/> </glyph> <glyph class="simple chemical" id="s434_sa1216"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:17621 KEGGCOMPOUND:C00061 CAS:146-17-8 </body> </html> </notes> <label text="FMN"/> <bbox w="70.0" h="25.0" x="10949.0" y="1520.0"/> </glyph> <glyph class="simple chemical" id="s3664_sa2666"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:15372 KEGGCOMPOUND: C00272 CAS: 17528-72-2 </body> </html> </notes> <label text="tetrahydrobiopterin"/> <bbox w="114.66052" h="25.361967" x="10904.0" y="1554.6381"/> </glyph> </glyph> <glyph class="complex" id="s2464_csa106" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2:BECN1:UVRAG Identifiers_end References_begin: PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2:BECN1"/> <bbox w="190.0" h="119.0" x="9777.5" y="2033.0"/> <glyph class="macromolecule" id="s4393_sa1221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="9875.5" y="2046.0"/> <glyph class="state variable" id="_2f49d22b-bf1e-4f91-8610-a462a32743e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9893.932" y="2041.0"/> </glyph> <glyph class="state variable" id="_d9035ac5-85a7-4bcf-8dfa-b09434b62479"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9927.068" y="2041.0"/> </glyph> <glyph class="state variable" id="_1cf59de9-91f9-4b57-ad2c-c523eb38c795"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9870.5" y="2061.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2465_sa1222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23377657 PMID:17446862 PMID:27754749 References_end </body> </html> </notes> <label text="BECN1"/> <bbox w="80.0" h="40.0" x="9876.947" y="2092.9004"/> <glyph class="state variable" id="_9b3eb1d0-c8a9-4fbc-9b91-68f034ee8c8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9871.947" y="2087.9004"/> </glyph> <glyph class="state variable" id="_e0c1f6bf-ed0f-447e-924a-5b64c73f5411"> <state value="" variable="T119"/> <bbox w="30.0" h="10.0" x="9918.896" y="2087.9004"/> </glyph> </glyph> <glyph class="macromolecule" id="s6257_sa4420"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="80.0" h="40.0" x="9787.5" y="2044.0"/> </glyph> </glyph> <glyph class="source and sink" id="s2467_sa1227" compartmentRef="c1_ca1"> <label text="s2428"/> <bbox w="30.0" h="30.0" x="5102.0" y="1212.0"/> </glyph> <glyph class="complex" id="s2468_csa107" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:KEAP1:RBX1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="KEAP1_E3_ligase_complex"/> <bbox w="189.0" h="123.0" x="8725.5" y="1308.5"/> <glyph class="macromolecule" id="s2470_sa1228"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <bbox w="80.0" h="40.0" x="8740.0" y="1328.0"/> </glyph> <glyph class="macromolecule" id="s2470_sa1229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <bbox w="80.0" h="40.0" x="8750.0" y="1340.0"/> </glyph> <glyph class="macromolecule" id="s2472_sa1230"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="8830.0" y="1320.0"/> </glyph> <glyph class="macromolecule" id="s2474_sa1231"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="8830.0" y="1360.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2475_sa1226" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end </body> </html> </notes> <label text="IKKβ*"/> <bbox w="80.0" h="40.0" x="5187.0" y="1207.0"/> <glyph class="state variable" id="_b3ffea59-ab3c-41f1-a0ff-39be267902de"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5205.4316" y="1202.0"/> </glyph> <glyph class="state variable" id="_ca88c895-99fb-4c7c-95aa-bd43c3a298ac"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5233.5684" y="1202.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2476_sa1234" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <bbox w="80.0" h="40.0" x="8880.0" y="1470.0"/> <glyph class="state variable" id="_0e1c1300-5af1-41e1-a453-830887964f2a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8931.568" y="1465.0"/> </glyph> <glyph class="state variable" id="_7d9081f9-716a-44ca-8763-1998ca01364b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="8893.432" y="1465.0"/> </glyph> </glyph> <glyph class="source and sink" id="s2477_sa1235" compartmentRef="c1_ca1"> <label text="s2373"/> <bbox w="30.0" h="30.0" x="9045.0" y="1475.0"/> </glyph> <glyph class="complex" id="s2485_csa124" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CISH:CUL2:RBX1:TCEB1:TCEB2:TCEB3 Identifiers_end </body> </html> </notes> <label text="CISH:Elongin:CUL2~E3_ligase_complex"/> <bbox w="182.0" h="170.0" x="4169.0" y="3045.0"/> <glyph class="macromolecule" id="s285_sa1308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) HUGO:TCEB1 HGNC:11617 ENTREZ:6921 UNIPROT:Q15369 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: subunit C References_end </body> </html> </notes> <label text="TCEB1"/> <bbox w="80.0" h="40.0" x="4259.0" y="3051.0"/> </glyph> <glyph class="macromolecule" id="s1490_sa1309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) HUGO:TCEB3 HGNC:11620 ENTREZ:6924 UNIPROT:Q14241 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: subunit A1 References_end </body> </html> </notes> <label text="TCEB3"/> <bbox w="80.0" h="40.0" x="4261.0" y="3135.0"/> </glyph> <glyph class="macromolecule" id="s273_sa1310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) HUGO:TCEB2 HGNC:11619 ENTREZ:6923 UNIPROT:Q15370 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: subunit B References_end </body> </html> </notes> <label text="TCEB2"/> <bbox w="80.0" h="40.0" x="4261.0" y="3095.0"/> </glyph> <glyph class="macromolecule" id="s1492_sa1311"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 2 HUGO:CUL2 HGNC:2552 ENTREZ:8453 UNIPROT:Q13617 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CUL2"/> <bbox w="80.0" h="40.0" x="4177.0" y="3095.0"/> </glyph> <glyph class="macromolecule" id="s1494_sa1312"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="4178.0" y="3136.0"/> </glyph> <glyph class="macromolecule" id="s269_sa1313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytokine inducible SH2-containing protein HUGO:CISH HGNC:1984 ENTREZ:1154 UNIPROT:Q9NSE2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CISH"/> <bbox w="80.0" h="40.0" x="4175.0" y="3051.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2487_sa1316" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: N-myc downstream regulated 1 HUGO:NDRG1 HGNC:7679 ENTREZ:10397 UNIPROT:Q92597 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="NDRG1"/> <bbox w="80.0" h="40.0" x="4496.619" y="3150.6548"/> </glyph> <glyph class="macromolecule" id="s2488_sa3181" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:JNK1 synonym:JNK2 synonym:JNK3 References_end </body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="4300.0" y="2290.0"/> <glyph class="state variable" id="_04fd1d6a-812a-4175-bd86-ae81a1e6f5f3"> <state value="P" variable="T183"/> <bbox w="35.0" h="10.0" x="4306.095" y="2285.0"/> </glyph> <glyph class="state variable" id="_24ccc77b-a0f9-4981-944e-5c3d6a5a83f8"> <state value="P" variable="Y185"/> <bbox w="35.0" h="10.0" x="4339.449" y="2285.0"/> </glyph> </glyph> <glyph class="source and sink" id="s2491_sa1334" compartmentRef="c13_ca13"> <label text="s1413"/> <bbox w="30.0" h="30.0" x="3927.5" y="7800.0"/> </glyph> <glyph class="complex" id="s2495_csa126" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP2:KLF8 Identifiers_end </body> </html> </notes> <label text="CTBP2:KLF3"/> <bbox w="100.0" h="120.0" x="3112.5" y="7635.0"/> <glyph class="macromolecule" id="s2498_sa1337"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="3122.5" y="7685.0"/> </glyph> <glyph class="macromolecule" id="s2494_sa1339"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CTBP2"/> <bbox w="80.0" h="40.0" x="3122.5" y="7645.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2496_sa1340" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CTBP2"/> <bbox w="80.0" h="40.0" x="3302.5" y="7655.0"/> </glyph> <glyph class="macromolecule" id="s2497_sa1324" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="3302.5" y="7705.0"/> </glyph> <glyph class="macromolecule" id="s2499_sa1341" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-interacting killer (apoptosis-inducing) HUGO:BIK HGNC:1051 ENTREZ:638 UNIPROT:Q13323 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BIK"/> <bbox w="80.0" h="40.0" x="2720.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s2500_sa1343" compartmentRef="c8_ca8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 4 HUGO:SLC2A4 HGNC:11009 ENTREZ:6517 UNIPROT:P14672 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT4 References_end </body> </html> </notes> <label text="SLC2A4"/> <bbox w="80.0" h="40.0" x="500.0" y="340.0"/> </glyph> <glyph class="macromolecule" id="s2506_sa1369" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="3577.1763" y="2867.6548"/> <glyph class="state variable" id="_7d740d38-ef13-4b40-80e3-373d805b2229"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3626.2449" y="2862.6548"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2507_sa1498" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <bbox w="70.0" h="25.0" x="4482.0" y="7325.5"/> </glyph> <glyph class="macromolecule" id="s2508_sa1375" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 heat shock protein 90kDa alpha (cytosolic), class A member 2 HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HSP90*"/> <bbox w="80.0" h="40.0" x="7490.0" y="5360.0"/> </glyph> <glyph class="macromolecule" id="s2511_sa1378" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class B member 1 HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HSP90AB1"/> <bbox w="80.0" h="40.0" x="7647.75" y="5398.75"/> </glyph> <glyph class="macromolecule" id="s2514_sa3989" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 27kDa protein 1 HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:HSP27PMID:11003656 References_end </body> </html> </notes> <label text="HSPB1"/> <bbox w="80.0" h="40.0" x="7662.5" y="7985.0"/> </glyph> <glyph class="complex" id="s2517_csa137" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:HSP90* Identifiers_end </body> </html> </notes> <label text="APAF1:HSP90A*"/> <bbox w="100.0" h="120.0" x="7000.0" y="5820.0"/> <glyph class="macromolecule" id="s2519_sa1415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 heat shock protein 90kDa alpha (cytosolic), class A member 2 HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HSP90*"/> <bbox w="80.0" h="40.0" x="7010.0" y="5870.0"/> </glyph> <glyph class="macromolecule" id="s4916_sa1416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="7010.0" y="5830.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2520_sa2357" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="90.0" h="25.0" x="2768.0" y="7079.75"/> <glyph class="unit of information" id="_13f898d5-c343-4370-8990-284a209f5abc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2803.0" y="7074.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2522_sa702" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: YY1 transcription factor HUGO:YY1 HGNC:12856 ENTREZ:7528 UNIPROT:P25490 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="YY1"/> <bbox w="90.0" h="25.0" x="6117.5" y="7088.5"/> <glyph class="unit of information" id="_3fd22e9e-81dc-4924-a982-fd80d19e47cf"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6152.5" y="7083.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2523_sa1417" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="7230.0" y="3060.0"/> <glyph class="state variable" id="_04b1f36a-3257-47df-ba47-a0557b5f9fe4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7248.4316" y="3055.0"/> </glyph> <glyph class="state variable" id="_60f94077-32df-42c1-bd1e-160e58819f10"> <state value="P" variable="S87"/> <bbox w="30.0" h="10.0" x="7271.949" y="3055.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2525_sa1422" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="7190.0" y="5260.0"/> <glyph class="state variable" id="_47a3a7c4-0faf-4a18-9318-94b2fef08d43"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="7196.095" y="5255.0"/> </glyph> <glyph class="state variable" id="_75f1aa51-a9b8-4477-9e30-a42ee3405455"> <state value="P" variable="S196"/> <bbox w="35.0" h="10.0" x="7229.449" y="5255.0"/> </glyph> <glyph class="state variable" id="_ecbd6b03-055d-4cc3-b2e5-9d1c4ba17440"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="7228.8306" y="5295.0"/> </glyph> <glyph class="state variable" id="_33824b4b-e63f-4b7e-8120-163cdb1807ce"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="7195.4756" y="5295.0"/> </glyph> <glyph class="state variable" id="_06ee9375-f2bf-42ef-b420-57a54e398736"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="7257.5" y="5275.0"/> </glyph> <glyph class="state variable" id="_4cc0f467-e1f4-4598-9c2d-bc60edbe1c66"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7185.0" y="5275.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2526_sa1423" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6953.75" y="5262.5"/> <glyph class="state variable" id="_e3455ac8-dd54-425d-8d05-520e009edb5f"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="6959.845" y="5257.5"/> </glyph> <glyph class="state variable" id="_61ab1eba-11a8-4baa-8c9f-e527432edd66"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="6995.699" y="5257.5"/> </glyph> <glyph class="state variable" id="_f28ac3a7-cb6f-41b3-bdd4-e2c9acfabb5a"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="6992.5806" y="5297.5"/> </glyph> <glyph class="state variable" id="_b3e39e5b-7355-4ac1-8b3a-61b55748d67d"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="6959.2256" y="5297.5"/> </glyph> <glyph class="state variable" id="_b853a56d-a91b-4784-ae16-3a3ff77e417c"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="7021.25" y="5277.5"/> </glyph> <glyph class="state variable" id="_c471ec8e-d118-4f27-bbf9-475b0cc04455"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6948.75" y="5277.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2527_sa1425" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6751.3335" y="4894.0"/> <glyph class="state variable" id="_9a0bae75-95fc-4670-8e79-6a4597214d24"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="6757.4287" y="4889.0"/> </glyph> <glyph class="state variable" id="_71dfd411-86f6-4207-aca6-d45cb151ff22"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="6790.7827" y="4889.0"/> </glyph> <glyph class="state variable" id="_a1f078f5-5fa1-4fac-8f8f-2b0294cc6655"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="6790.164" y="4929.0"/> </glyph> <glyph class="state variable" id="_723969da-438c-4540-aafb-65ec01cb3b15"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="6759.309" y="4929.0"/> </glyph> <glyph class="state variable" id="_7b93da84-d66f-4818-a9a0-3fec37aa3282"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="6818.8335" y="4909.0"/> </glyph> <glyph class="state variable" id="_b95b8501-c816-47a8-bd80-d8e90cb945d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6746.3335" y="4909.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2528_sa1428" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6726.291" y="3806.7236"/> <glyph class="state variable" id="_1ce0f663-7937-49b5-9a80-64aa63a091e3"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="6734.886" y="3801.7236"/> </glyph> <glyph class="state variable" id="_e9c49343-2bdb-4f0b-a6b3-086a1b829bfb"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="6765.74" y="3801.7236"/> </glyph> <glyph class="state variable" id="_46f342bf-8f87-45c9-aa8e-89826b413da2"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="6765.1216" y="3841.7236"/> </glyph> <glyph class="state variable" id="_6171ce73-7d45-4386-8b65-644351ab0752"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="6731.7666" y="3841.7236"/> </glyph> <glyph class="state variable" id="_f81a8adc-6447-49ba-ada4-2a7d80d4d915"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="6793.791" y="3821.7236"/> </glyph> <glyph class="state variable" id="_5e427455-8b45-4c67-9070-0749d9d870ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6721.291" y="3821.7236"/> </glyph> </glyph> <glyph class="macromolecule" id="s2529_sa3186" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:p38_beta_ synonym:p38_gamma_ synonym:p38_delta_ synonym:p38 References_end </body> </html> </notes> <label text="p38*"/> <bbox w="80.0" h="40.0" x="5180.0" y="2110.0"/> <glyph class="state variable" id="_ee015a7b-c3ca-4fda-83a3-cd61e5cc0834"> <state value="P" variable="Y182"/> <bbox w="35.0" h="10.0" x="5219.449" y="2105.0"/> </glyph> <glyph class="state variable" id="_583b2539-e143-4bce-900d-5b9c43712b35"> <state value="P" variable="T180"/> <bbox w="35.0" h="10.0" x="5186.095" y="2105.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2530_sa1433" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="DYRK1A"/> <bbox w="80.0" h="40.0" x="6823.666" y="3681.7236"/> </glyph> <glyph class="macromolecule" id="s2531_sa1436" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. 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References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="7150.0" y="5128.0"/> <glyph class="state variable" id="_32503c64-02e0-4323-9b92-e67dd70ea039"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="7156.095" y="5123.0"/> </glyph> <glyph class="state variable" id="_79ddefc7-c98d-45af-8bc6-1a4235f1616f"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="7189.449" y="5123.0"/> </glyph> <glyph class="state variable" id="_d432bb15-578e-4317-a25b-42da1afae769"> <state value="P" variable="Y153"/> <bbox w="35.0" h="10.0" x="7188.8306" y="5163.0"/> </glyph> <glyph class="state variable" id="_1895f3fd-5c6a-41ad-b235-986790af8c4d"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="7155.4756" y="5163.0"/> </glyph> <glyph class="state variable" id="_88343d1d-b693-4034-be85-eab5af350d91"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="7217.5" y="5143.0"/> </glyph> <glyph class="state variable" id="_18822d68-4152-4e1e-b6fd-3181ba4035e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7145.0" y="5143.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2532_sa1437" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6940.0" y="5130.0"/> <glyph class="state variable" id="_7423b04a-8b85-4d1a-953e-346172ddf5c8"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="6946.095" y="5125.0"/> </glyph> <glyph class="state variable" id="_3e242969-86b8-4619-834a-320598e72832"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="6979.449" y="5125.0"/> </glyph> <glyph class="state variable" id="_cf912aea-2669-49ad-9efe-ba2b309f85c5"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="6981.3306" y="5165.0"/> </glyph> <glyph class="state variable" id="_50c1735c-70d9-485f-a6ed-0dbfd8dfd819"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="6945.4756" y="5165.0"/> </glyph> <glyph class="state variable" id="_ee723851-ca63-4763-91e1-31c98e121e27"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="7007.5" y="5145.0"/> </glyph> <glyph class="state variable" id="_f6cb81e8-522e-4222-a5df-190eff98d9bf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6935.0" y="5145.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2533_sa1825" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6580.0" y="5120.0"/> <glyph class="state variable" id="_ecf2381b-b309-4476-a8ad-802e6fa841f8"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="6586.095" y="5115.0"/> </glyph> <glyph class="state variable" id="_df87c92c-13cc-4746-84bf-d97f54b5a570"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="6619.449" y="5115.0"/> </glyph> <glyph class="state variable" id="_d052fff1-3c1b-4e27-96e5-11fe997e59a1"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="6618.8306" y="5155.0"/> </glyph> <glyph class="state variable" id="_de3ff9b9-e6b3-451c-971d-2557695f6975"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="6585.4756" y="5155.0"/> </glyph> <glyph class="state variable" id="_5711c614-5408-46bd-9b04-8c9302e4478d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="6647.5" y="5135.0"/> </glyph> <glyph class="state variable" id="_c607214d-7a9a-4b26-8f2e-c8b7470df7df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6575.0" y="5135.0"/> </glyph> </glyph> <glyph class="complex" id="s2534_csa139" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase9*:XIAP Identifiers_end </body> </html> </notes> <label text="CASP9:XIAP"/> <bbox w="100.0" h="120.0" x="6750.0" y="5080.0"/> <glyph class="macromolecule" id="s2535_sa1443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. 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<body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="4463.25" y="4103.0"/> <glyph class="state variable" id="_6ce3a8dd-a394-4d84-be15-b63b1fc11d3d"> <state value="My" variable=""/> <bbox w="20.0" h="10.0" x="4477.466" y="4138.0"/> </glyph> <glyph class="unit of information" id="_4afc18a1-4e24-4ea1-9a3f-6439b5a5c8d0"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4478.25" y="4098.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2547_sa2404" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor B2, mitochondrial HUGO:TFB2M HGNC:18559 ENTREZ:64216 UNIPROT:Q9H5Q4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFB2M"/> <bbox w="70.0" h="25.0" x="2424.5" y="7322.0"/> </glyph> <glyph class="macromolecule" id="s2548_sa2399" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor B1, mitochondrial HUGO:TFB1M HGNC:17037 ENTREZ:51106 UNIPROT:Q8WVM0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFB1M"/> <bbox w="80.0" h="40.0" x="3484.25" y="5475.0"/> </glyph> <glyph class="macromolecule" id="s2549_sa2405" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor B2, mitochondrial HUGO:TFB2M HGNC:18559 ENTREZ:64216 UNIPROT:Q9H5Q4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFB2M"/> <bbox w="80.0" h="40.0" x="3374.25" y="5475.0"/> </glyph> <glyph class="nucleic acid feature" id="s2554_sa2354" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 3 HUGO:PRDX3 HGNC:9354 ENTREZ:10935 UNIPROT:P30048 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PRDX3"/> <bbox w="70.0" h="25.0" x="7237.977" y="7341.7983"/> </glyph> <glyph class="nucleic acid feature" id="s2556_sa2355" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 3 HUGO:PRDX3 HGNC:9354 ENTREZ:10935 UNIPROT:P30048 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PRDX3"/> <bbox w="90.0" h="25.0" x="7382.5" y="7106.5"/> <glyph class="unit of information" id="_5edfca1b-984d-46be-8a7c-0efdadaa207f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7417.5" y="7101.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2558_sa2391" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CyclinD1*"/> <bbox w="80.0" h="40.0" x="2202.5" y="7715.0"/> </glyph> <glyph class="macromolecule" id="s2559_sa2390" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear respiratory factor 1 HUGO:NRF1 HGNC:7996 ENTREZ:4899 UNIPROT:Q16656 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="NRF1"/> <bbox w="80.0" h="40.0" x="1932.5" y="7765.0"/> <glyph class="state variable" id="_afc9db05-a48d-410f-8370-c7de7db74974"> <state value="P" variable="S47"/> <bbox w="30.0" h="10.0" x="1974.0686" y="7760.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2561_sa2408" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) HUGO:NDUFS8 HGNC:7715 ENTREZ:4728 UNIPROT:O00217 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS8"/> <bbox w="70.0" h="25.0" x="2425.0" y="7364.5"/> </glyph> <glyph class="macromolecule" id="s2562_sa2409" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) HUGO:NDUFS8 HGNC:7715 ENTREZ:4728 UNIPROT:O00217 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS8"/> <bbox w="80.0" h="40.0" x="439.25" y="4824.25"/> </glyph> <glyph class="macromolecule" id="s2563_sa2448" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit B, iron sulfur (Ip) HUGO:SDHB HGNC:10681 ENTREZ:6390 UNIPROT:P21912 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: iron-sulfur protein References_end </body> </html> </notes> <label text="SDHB"/> <bbox w="80.0" h="40.0" x="644.25" y="5075.0"/> </glyph> <glyph class="macromolecule" id="s2564_sa2449" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa HUGO:SDHC HGNC:10682 ENTREZ:6391 UNIPROT:Q99643 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: mono-heme cytochrome b References_end </body> </html> </notes> <label text="SDHC"/> <bbox w="80.0" h="40.0" x="644.25" y="5115.0"/> </glyph> <glyph class="macromolecule" id="s2565_sa2450" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit D, integral membrane protein HUGO:SDHD HGNC:10683 ENTREZ:6392 UNIPROT:O14521 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: cytochrome b560 References_end </body> </html> </notes> <label text="SDHD"/> <bbox w="80.0" h="40.0" x="644.25" y="5155.0"/> </glyph> <glyph class="macromolecule" id="s2569_sa2438" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIa polypeptide 1 HUGO:COX6A1 HGNC:2277 ENTREZ:1337 UNIPROT:P12074 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6A1"/> <bbox w="80.0" h="40.0" x="2056.75" y="4895.0"/> </glyph> <glyph class="macromolecule" id="s2570_sa2439" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIa polypeptide 1 HUGO:COX6A1 HGNC:2277 ENTREZ:1337 UNIPROT:P12074 cytochrome c oxidase subunit VIa polypeptide 2 HUGO:COX6A2 HGNC:2279 ENTREZ:1339 UNIPROT:Q02221 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6A*"/> <bbox w="80.0" h="40.0" x="2086.75" y="4805.0"/> </glyph> <glyph class="macromolecule" id="s2571_sa2432" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIIa polypeptide 2 (liver) HUGO:COX7A2 HGNC:2288 ENTREZ:1347 UNIPROT:P14406 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7A2"/> <bbox w="80.0" h="40.0" x="1886.75" y="4895.0"/> </glyph> <glyph class="macromolecule" id="s2572_sa2433" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) HUGO:COX7A1 HGNC:2287 ENTREZ:1346 UNIPROT:P24310 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) HUGO:COX7A2 HGNC:2288 ENTREZ:1347 UNIPROT:P14406 cytochrome c oxidase subunit VIIa polypeptide 2 like HUGO:COX7A2L HGNC:2289 ENTREZ:9167 UNIPROT:O14548 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7A*"/> <bbox w="80.0" h="40.0" x="1906.75" y="4805.0"/> </glyph> <glyph class="macromolecule" id="s2575_sa2426" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide HUGO:ATP5B HGNC:830 ENTREZ:506 UNIPROT:P06576 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5B"/> <bbox w="80.0" h="40.0" x="2574.615" y="4605.7173"/> </glyph> <glyph class="nucleic acid feature" id="s2576_sa2425" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide HUGO:ATP5B HGNC:830 ENTREZ:506 UNIPROT:P06576 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5B"/> <bbox w="70.0" h="25.0" x="2262.0" y="7365.5"/> </glyph> <glyph class="nucleic acid feature" id="s2577_sa2431" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIIa polypeptide 2 (liver) HUGO:COX7A2 HGNC:2288 ENTREZ:1347 UNIPROT:P14406 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7A2"/> <bbox w="70.0" h="25.0" x="2192.0" y="7325.5"/> </glyph> <glyph class="nucleic acid feature" id="s2580_sa2422" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: surfeit 1 HUGO:SURF1 HGNC:11474 ENTREZ:6834 UNIPROT:Q15526 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SURF1"/> <bbox w="70.0" h="25.0" x="2264.5" y="7322.0"/> </glyph> <glyph class="macromolecule" id="s2581_sa2419" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 1 References_end </body> </html> </notes> <label text="VDAC1"/> <bbox w="80.0" h="40.0" x="5778.5" y="5528.25"/> </glyph> <glyph class="macromolecule" id="s2582_sa2457" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 3 References_end </body> </html> </notes> <label text="VDAC3"/> <bbox w="80.0" h="40.0" x="5780.0" y="5460.0"/> </glyph> <glyph class="nucleic acid feature" id="s2583_sa2420" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="VDAC1"/> <bbox w="70.0" h="25.0" x="2346.0" y="7360.5"/> </glyph> <glyph class="macromolecule" id="s2584_sa2460" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrial ribosomal protein S12 HUGO:MRPS12 HGNC:10380 ENTREZ:6183 UNIPROT:O15235 Identifiers_end </body> </html> </notes> <label text="MRPS12"/> <bbox w="80.0" h="40.0" x="1880.0" y="6140.0"/> </glyph> <glyph class="simple chemical" id="s2585_sa2179" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15380 KEGGCOMPOUND:C00091 CAS:604-98-8 Identifiers_end </body> </html> </notes> <label text="succinyl-CoA"/> <bbox w="70.0" h="25.0" x="1026.7261" y="3859.1462"/> </glyph> <glyph class="simple chemical" id="s2586_sa2181" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15428 CAS:56-40-6 Identifiers_end References_begin: COMPOUND:C00037 References_end </body> </html> </notes> <label text="glycine"/> <bbox w="70.0" h="25.0" x="1104.7739" y="3876.25"/> </glyph> <glyph class="simple chemical" id="s2589_sa2183" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15346 KEGGCOMPOUND:C00010 Identifiers_end References_begin: charge:0 85-61-0 References_end </body> </html> </notes> <label text="coenzyme A"/> <bbox w="70.0" h="25.0" x="1108.7261" y="3943.1462"/> </glyph> <glyph class="complex" id="s2591_csa274" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ALAS*:pyridoxal 5 Identifiers_end </body> </html> </notes> <label text="ALAS"/> <bbox w="98.0" h="94.0" x="879.774" y="3879.75"/> <glyph class="macromolecule" id="s2592_sa2184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 aminolevulinate, delta-, synthase 2 HUGO:ALAS2 HGNC:397 ENTREZ:212 UNIPROT:P22557 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS*"/> <bbox w="80.0" h="40.0" x="882.726" y="3886.1462"/> </glyph> <glyph class="macromolecule" id="s2592_sa2185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 aminolevulinate, delta-, synthase 2 HUGO:ALAS2 HGNC:397 ENTREZ:212 UNIPROT:P22557 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS*"/> <bbox w="80.0" h="40.0" x="892.726" y="3896.1462"/> </glyph> <glyph class="simple chemical" id="s2605_sa2186"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:18405 KEGGCOMPOUND: C00018 CAS: 54-47-7 </body> </html> </notes> <label text="pyridoxal 5'-phosphate"/> <bbox w="70.0" h="25.0" x="890.774" y="3925.25"/> </glyph> </glyph> <glyph class="simple chemical" id="s2593_sa2191" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:2034 KEGGCOMPOUND:C00430 Identifiers_end References_begin: 106-60-5 References_end </body> </html> </notes> <label text="5 aminolevulinic acid"/> <bbox w="134.95204" h="27.603666" x="172.52397" y="3766.1982"/> </glyph> <glyph class="simple chemical" id="s2594_sa2190" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:8335 KEGGCOMPOUND:C00931 CAS:487-90-1 Identifiers_end </body> </html> </notes> <label text="porphobilinogen"/> <bbox w="105.0" h="26.5" x="187.5" y="3896.75"/> </glyph> <glyph class="simple chemical" id="s2595_sa2182" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:2034 KEGGCOMPOUND:C00430 Identifiers_end References_begin: 106-60-5 References_end </body> </html> </notes> <label text="5 aminolevulinic acid"/> <bbox w="70.0" h="25.0" x="1030.7739" y="3966.25"/> </glyph> <glyph class="complex" id="s2602_csa275" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ALAD:Zn2+ Identifiers_end </body> </html> </notes> <label text="ALAD octamer"/> <bbox w="204.0" h="102.0" x="148.0" y="3639.0"/> <glyph class="macromolecule multimer" id="s4449_sa3413"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aminolevulinate dehydratase HUGO:ALAD HGNC:395 ENTREZ:210 UNIPROT:P13716 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAD"/> <bbox w="86.0" h="46.0" x="153.47603" y="3644.4482"/> <glyph class="unit of information" id="_53129748-abc6-40dc-b13d-52ee92a986e0"> <label text="N:8"/> <bbox w="20.0" h="10.0" x="186.47603" y="3639.4482"/> </glyph> </glyph> <glyph class="simple chemical multimer" id="s4450_sa3414"> <label text="Zn2+"/> <bbox w="31.0" h="31.0" x="296.024" y="3691.5518"/> <glyph class="unit of information" id="_5a238e85-478c-4c4c-b9ec-c2a5f6bddaa5"> <label text="N:8"/> <bbox w="20.0" h="10.0" x="301.524" y="3686.5518"/> </glyph> </glyph> </glyph> <glyph class="simple chemical" id="s2606_sa2192" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:5809 KEGGCOMPOUND:C01024 CAS:73023-76-4 Identifiers_end References_begin: synonym:preuroporphyrinogen References_end </body> </html> </notes> <label text="hydroxymethylbilane"/> <bbox w="136.0" h="27.5" x="172.0" y="3996.25"/> </glyph> <glyph class="macromolecule" id="s2607_sa2189" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hydroxymethylbilane synthase HUGO:HMBS HGNC:4982 ENTREZ:3145 UNIPROT:P08397 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="HMBS"/> <bbox w="80.0" h="40.0" x="280.0" y="3930.0"/> </glyph> <glyph class="simple chemical" id="s2609_sa2196" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:9905 KEGGCOMPOUND:C01051 CAS:1976-85-8 Identifiers_end </body> </html> </notes> <label text="uroporphyrinogen III"/> <bbox w="140.0" h="25.5" x="170.0" y="4084.5"/> </glyph> <glyph class="macromolecule" id="s2610_sa2193" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: uroporphyrinogen III synthase HUGO:UROS HGNC:12592 ENTREZ:7390 UNIPROT:P10746 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="UROS"/> <bbox w="80.0" h="40.0" x="282.0" y="4036.0"/> </glyph> <glyph class="simple chemical" id="s2611_sa2198" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:3880 KEGGCOMPOUND:C03263 CAS:2624-63-7 Identifiers_end </body> </html> </notes> <label text="coproporphyrinogen III"/> <bbox w="152.0" h="27.5" x="164.0" y="4186.25"/> </glyph> <glyph class="simple chemical" id="s2617_sa2215" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:3880 KEGGCOMPOUND:C03263 CAS:2624-63-7 Identifiers_end </body> </html> </notes> <label text="coproporphyrinogen III"/> <bbox w="70.0" h="25.0" x="1027.702" y="4032.0815"/> </glyph> <glyph class="simple chemical" id="s2620_sa2216" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:8593 KEGGCOMPOUND:C01079 CAS:7412-77-3 Identifiers_end </body> </html> </notes> <label text="protoporphyrinogen"/> <bbox w="70.0" h="25.0" x="1027.75" y="4136.25"/> </glyph> <glyph class="complex" id="s2622_csa277" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CPOX Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CPOX"/> <bbox w="100.0" h="76.0" x="874.75" y="4066.75"/> <glyph class="macromolecule" id="s2623_sa2222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: coproporphyrinogen oxidase HUGO:CPOX HGNC:2321 ENTREZ:1371 UNIPROT:P36551 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CPOX"/> <bbox w="80.0" h="40.0" x="881.702" y="4073.0815"/> </glyph> <glyph class="macromolecule" id="s2623_sa2223"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: coproporphyrinogen oxidase HUGO:CPOX HGNC:2321 ENTREZ:1371 UNIPROT:P36551 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CPOX"/> <bbox w="80.0" h="40.0" x="891.702" y="4083.0815"/> </glyph> </glyph> <glyph class="simple chemical" id="s2624_sa2221" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:8592 KEGGCOMPOUND:C02191 CAS:553-12-8 Identifiers_end </body> </html> </notes> <label text="protoporphyrin IX"/> <clone/> <bbox w="70.0" h="25.0" x="1027.75" y="4235.25"/> </glyph> <glyph class="simple chemical" id="s2624_sa2228" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:8592 KEGGCOMPOUND:C02191 CAS:553-12-8 Identifiers_end </body> </html> </notes> <label text="protoporphyrin IX"/> <clone/> <bbox w="115.1504" h="22.706215" x="1366.6748" y="4075.647"/> </glyph> <glyph class="complex" id="s2628_csa278" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAD:PPOX Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PPOX"/> <bbox w="102.0" h="90.0" x="879.75" y="4159.75"/> <glyph class="macromolecule" id="s2728_sa2224"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protoporphyrinogen oxidase HUGO:PPOX HGNC:9280 ENTREZ:5498 UNIPROT:P50336 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PPOX"/> <bbox w="80.0" h="40.0" x="885.75" y="4164.25"/> </glyph> <glyph class="simple chemical" id="s2729_sa2225"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="886.75" y="4193.25"/> </glyph> <glyph class="macromolecule" id="s2728_sa2226"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protoporphyrinogen oxidase HUGO:PPOX HGNC:9280 ENTREZ:5498 UNIPROT:P50336 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PPOX"/> <bbox w="80.0" h="40.0" x="895.75" y="4174.25"/> </glyph> <glyph class="simple chemical" id="s2729_sa2227"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5 </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="896.75" y="4203.25"/> </glyph> </glyph> <glyph class="simple chemical" id="s2631_sa2229" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29033 KEGGCOMPOUND:C14818 CAS:15438-31-0 Identifiers_end </body> </html> </notes> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="1481.75" y="4034.5"/> </glyph> <glyph class="macromolecule" id="s2637_sa2309" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heme oxygenase (decycling) 1 HUGO:HMOX1 HGNC:5013 ENTREZ:3162 UNIPROT:P09601 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="HMOX1"/> <bbox w="80.0" h="40.0" x="10170.0" y="1450.0"/> </glyph> <glyph class="simple chemical" id="s2638_sa2308" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17627 KEGGCOMPOUND:C00032 CAS:14875-96-8 Identifiers_end </body> </html> </notes> <label text="ferroheme b"/> <bbox w="85.0" h="22.5" x="10255.0" y="1377.5"/> </glyph> <glyph class="simple chemical" id="s2639_sa2313" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17033 KEGGCOMPOUND:C00500 CAS:114-25-0 Identifiers_end </body> </html> </notes> <label text="biliverdin"/> <bbox w="70.0" h="25.0" x="10260.054" y="1533.269"/> </glyph> <glyph class="simple chemical" id="s2640_sa2311" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17245 KEGGCOMPOUND:C00237 CAS:630-08-0 Identifiers_end </body> </html> </notes> <label text="CO"/> <bbox w="70.0" h="25.0" x="10334.054" y="1474.269"/> </glyph> <glyph class="complex" id="s2647_csa288" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BACH1:small~MAF* Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="206.0" h="99.0" x="7059.5" y="7725.5"/> <glyph class="macromolecule" id="s2648_sa2333"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="7133.125" y="7731.116"/> </glyph> <glyph class="macromolecule" id="s2648_sa2334"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="7149.125" y="7741.116"/> </glyph> <glyph class="macromolecule" id="s2648_sa2335"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="7160.125" y="7751.116"/> </glyph> <glyph class="macromolecule" id="s2648_sa2336"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="7178.125" y="7761.116"/> </glyph> <glyph class="macromolecule" id="s2651_sa2337"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: genetic entity References_end </body> </html> </notes> <label text="small~MAF*"/> <bbox w="80.0" h="40.0" x="7071.125" y="7731.116"/> </glyph> <glyph class="macromolecule" id="s2651_sa2338"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: genetic entity References_end </body> </html> </notes> <label text="small~MAF*"/> <bbox w="80.0" h="40.0" x="7091.125" y="7741.116"/> </glyph> <glyph class="macromolecule" id="s2651_sa2339"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: genetic entity References_end </body> </html> </notes> <label text="small~MAF*"/> <bbox w="80.0" h="40.0" x="7111.125" y="7751.116"/> </glyph> <glyph class="macromolecule" id="s2651_sa2340"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: genetic entity References_end </body> </html> </notes> <label text="small~MAF*"/> <bbox w="80.0" h="40.0" x="7131.125" y="7761.116"/> </glyph> </glyph> <glyph class="macromolecule" id="s2694_sa2246" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS1"/> <bbox w="80.0" h="40.0" x="744.25" y="3815.0"/> </glyph> <glyph class="macromolecule" id="s2695_sa2236" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate, delta-, synthase 2 HUGO:ALAS2 HGNC:397 ENTREZ:212 UNIPROT:P22557 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS2"/> <bbox w="80.0" h="40.0" x="739.25" y="3760.0"/> </glyph> <glyph class="simple chemical" id="s2697_sa2241" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30413 Identifiers_end </body> </html> </notes> <label text="heme"/> <clone/> <bbox w="70.0" h="25.0" x="625.0" y="3547.5"/> </glyph> <glyph class="simple chemical" id="s2697_sa2344" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30413 Identifiers_end </body> </html> </notes> <label text="heme"/> <clone/> <bbox w="70.0" h="25.0" x="11775.0" y="7527.5"/> </glyph> <glyph class="simple chemical" id="s2697_sa3268" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30413 Identifiers_end </body> </html> </notes> <label text="heme"/> <clone/> <bbox w="70.0" h="25.0" x="6137.0" y="1715.0"/> </glyph> <glyph class="complex" id="s2699_csa280" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ALAS1:heme Identifiers_end </body> </html> </notes> <label text="ALAS1:heme"/> <bbox w="100.0" h="120.0" x="450.0" y="3520.0"/> <glyph class="simple chemical" id="s2701_sa2242"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:30413 </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="466.0" y="3588.75"/> </glyph> <glyph class="macromolecule" id="s2700_sa2243"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS1"/> <bbox w="80.0" h="40.0" x="459.0" y="3537.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s2702_sa2237" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 aminolevulinate, delta-, synthase 2 HUGO:ALAS2 HGNC:397 ENTREZ:212 UNIPROT:P22557 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS*"/> <bbox w="80.0" h="40.0" x="884.25" y="3785.0"/> </glyph> <glyph class="complex" id="s2705_csa295" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ESRRA:PPARGC1A Identifiers_end </body> </html> </notes> <label text="ERRα:PGC1α"/> <bbox w="100.0" h="120.0" x="2472.5" y="7495.0"/> <glyph class="macromolecule" id="s3851_sa2412"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: estrogen-related receptor alpha HUGO:ESRRA HGNC:3471 ENTREZ:2101 UNIPROT:P11474 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ESRRA"/> <bbox w="80.0" h="40.0" x="2488.5" y="7505.0"/> </glyph> <glyph class="macromolecule" id="s2706_sa2413"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="2485.5" y="7553.0"/> <glyph class="state variable" id="_f5e27a4d-e978-458c-918c-705c9ef6403f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2537.0686" y="7548.0"/> </glyph> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2707_sa2415" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 4 HUGO:PDK4 HGNC:8812 ENTREZ:5166 UNIPROT:Q16654 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDK4"/> <bbox w="70.0" h="25.0" x="2344.5" y="7322.0"/> </glyph> <glyph class="nucleic acid feature" id="s2708_sa2416" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase kinase, isozyme 4 HUGO:PDK4 HGNC:8812 ENTREZ:5166 UNIPROT:Q16654 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDK4"/> <bbox w="90.0" h="25.0" x="2300.0" y="7082.5"/> <glyph class="unit of information" id="_a3a92a29-f0df-4f22-a0d4-edadceeed5a4"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2335.0" y="7077.5"/> </glyph> </glyph> <glyph class="complex" id="s2712_csa281" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:PPARGC1A Identifiers_end </body> </html> </notes> <label text="FOXO1:PGC1α"/> <bbox w="100.0" h="120.0" x="5292.5" y="7675.0"/> <glyph class="macromolecule" id="s3562_sa2244"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="5304.5" y="7683.0"/> </glyph> <glyph class="macromolecule" id="s2711_sa2245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="5299.5" y="7733.0"/> <glyph class="state variable" id="_c2294f8f-5ae5-4dd7-9de5-4d6d1e14c471"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5351.0684" y="7728.0"/> </glyph> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2713_sa2240" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS1"/> <bbox w="70.0" h="25.0" x="4732.0" y="7319.5"/> </glyph> <glyph class="nucleic acid feature" id="s2714_sa2238" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS1"/> <bbox w="90.0" h="25.0" x="4803.0" y="7058.5"/> <glyph class="unit of information" id="_41dfd136-0b3f-4493-9bc1-ff8ab1bc04eb"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4838.0" y="7053.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2715_sa2379" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="1182.5" y="7095.0"/> <glyph class="state variable" id="_39246905-7977-48ed-b64c-c170c8d3da14"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="1229.0686" y="7090.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2716_sa2389" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="2466.0" y="6901.37"/> <glyph class="state variable" id="_d61d8696-5aa3-494d-91dd-30bfcb5c02a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2517.5686" y="6896.37"/> </glyph> </glyph> <glyph class="macromolecule" id="s2718_sa2378" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: K(lysine) acetyltransferase 2B HUGO:KAT2B HGNC:8638 ENTREZ:8850 UNIPROT:Q92831 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PCAF*"/> <bbox w="80.0" h="40.0" x="1252.5" y="7035.0"/> </glyph> <glyph class="nucleic acid feature" id="s2719_sa2353" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle HUGO:ATP5A1 HGNC:823 ENTREZ:498 UNIPROT:P25705 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5A1"/> <bbox w="70.0" h="25.0" x="3003.5" y="7347.25"/> </glyph> <glyph class="nucleic acid feature" id="s2721_sa2352" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle HUGO:ATP5A1 HGNC:823 ENTREZ:498 UNIPROT:P25705 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5A1"/> <bbox w="90.0" h="25.0" x="2853.0" y="7078.0"/> <glyph class="unit of information" id="_619412e1-f019-4051-a431-6e8fbb75a073"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2888.0" y="7073.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s2725_sa2194" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:471593 CAS:51568-18-4 Identifiers_end </body> </html> </notes> <label text="succinylacetone"/> <bbox w="125.0" h="22.5" x="247.5" y="3818.75"/> </glyph> <glyph class="nucleic acid feature" id="s2731_sa2324" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferrochelatase HUGO:FECH HGNC:3647 ENTREZ:2235 UNIPROT:P22830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="FECH"/> <bbox w="70.0" h="25.0" x="4969.0" y="7346.5"/> </glyph> <glyph class="nucleic acid feature" id="s2732_sa2325" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferrochelatase HUGO:FECH HGNC:3647 ENTREZ:2235 UNIPROT:P22830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="FECH"/> <bbox w="90.0" h="25.0" x="5064.0" y="7087.5"/> <glyph class="unit of information" id="_e4479076-1c21-4063-9ca3-8ee4b3b6c226"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5099.0" y="7082.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2733_sa2233" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferrochelatase HUGO:FECH HGNC:3647 ENTREZ:2235 UNIPROT:P22830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="FECH"/> <bbox w="80.0" h="40.0" x="1320.25" y="4173.842"/> </glyph> <glyph class="macromolecule" id="s2741_sa2879" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin interacting protein HUGO:TXNIP HGNC:16952 ENTREZ:10628 UNIPROT:Q9H3M7 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TXNIP"/> <bbox w="80.0" h="40.0" x="11310.0" y="1750.0"/> <glyph class="state variable" id="_4f32c1a6-47b4-4a08-88d7-6b33cff77c41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11361.568" y="1745.0"/> </glyph> </glyph> <glyph class="complex" id="s2742_csa320" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TXN:TXNIP Identifiers_end </body> </html> </notes> <label text="TXN:TXNIP"/> <bbox w="100.0" h="120.0" x="11170.5" y="1663.0"/> <glyph class="macromolecule" id="s2744_sa2881"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: thioredoxin interacting protein HUGO:TXNIP HGNC:16952 ENTREZ:10628 UNIPROT:Q9H3M7 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TXNIP"/> <bbox w="80.0" h="40.0" x="11180.5" y="1719.0"/> <glyph class="state variable" id="_2564af20-517f-40dc-b29d-a865372f4a5d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11232.068" y="1714.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2743_sa2882"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <bbox w="80.0" h="40.0" x="11179.5" y="1676.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2753_sa1478" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: beta-transducin repeat containing E3 ubiquitin protein ligase HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 F-box and WD repeat domain containing 11 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:beta-TrCP1 synonym:beta-TrCP2 References_end </body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="9712.027" y="3407.7634"/> </glyph> <glyph class="source and sink" id="s2755_sa1477" compartmentRef="c1_ca1"> <label text="s2755"/> <bbox w="30.0" h="30.0" x="9934.027" y="3465.7634"/> </glyph> <glyph class="complex" id="s2757_csa145" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BNIP3:RHEB Identifiers_end </body> </html> </notes> <label text="BNIP3:RHEB"/> <bbox w="100.0" h="120.0" x="9005.0" y="3215.0"/> <glyph class="macromolecule" id="s2756_sa1479"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Ras homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="9016.0" y="3270.0"/> <glyph class="state variable" id="_d3a48883-bdaf-4c15-bb36-4a2f69ee6fea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9034.432" y="3265.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2758_sa1480"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2/adenovirus E1B 19kDa interacting protein 3 HUGO:BNIP3 HGNC:1084 ENTREZ:664 UNIPROT:Q12983 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="BNIP3"/> <bbox w="80.0" h="40.0" x="9016.0" y="3224.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2759_sa2348" compartmentRef="c10_ca10"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: promyelocytic leukemia HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="2683.0" y="7769.5"/> </glyph> <glyph class="macromolecule" id="s2760_sa1484" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="222.5" y="7115.0"/> <glyph class="state variable" id="_6cf6f102-e761-4bda-a9f6-78fb08c84465"> <state value="?" variable="T366"/> <bbox w="35.0" h="10.0" x="228.59503" y="7110.0"/> </glyph> <glyph class="state variable" id="_36ee44f0-9a6e-40a4-afb0-9f0e124b1aa8"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="266.56854" y="7110.0"/> </glyph> </glyph> <glyph class="complex" id="s2761_csa146" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Mg2+:PDP1:PDPR Identifiers_end </body> </html> </notes> <label text="PDP"/> <bbox w="100.0" h="120.0" x="1944.25" y="5955.0"/> <glyph class="macromolecule" id="s3676_sa1485"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehyrogenase phosphatase catalytic subunit 1 HUGO:PDP1 HGNC:9279 ENTREZ:54704 UNIPROT:Q9P0J1 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDP1"/> <bbox w="80.0" h="40.0" x="1956.25" y="5971.0"/> </glyph> <glyph class="macromolecule" id="s2762_sa1486"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cancer susceptibility candidate 5 HUGO:CASC5 HGNC:24054 ENTREZ:57082 UNIPROT:Q8NG31 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: GeneID:55066 References_end </body> </html> </notes> <label text="PDPR"/> <bbox w="80.0" h="40.0" x="1956.25" y="6015.0"/> </glyph> <glyph class="simple chemical" id="s2515_sa1487"> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1949.75" y="5960.5"/> </glyph> <glyph class="simple chemical" id="s2515_sa1488"> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="2017.25" y="5964.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2765_sa56" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="cleaved~14-3-3*"/> <bbox w="80.0" h="40.0" x="7666.5874" y="4912.5884"/> <glyph class="unit of information" id="_450d66be-db4f-46b2-b68f-b33f90a2a624"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7681.5874" y="4907.5884"/> </glyph> </glyph> <glyph class="macromolecule" id="s2766_sa487" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 6, apoptosis-related cysteine peptidase HUGO:CASP6 HGNC:1507 ENTREZ:839 UNIPROT:P55212 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="cleaved~Caspase6*"/> <bbox w="80.0" h="40.0" x="7550.0" y="4190.0"/> <glyph class="unit of information" id="_3aae2948-ad00-4895-b35f-5c3a33589a3f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7565.0" y="4185.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2767_sa483" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="7330.0" y="4300.0"/> <glyph class="unit of information" id="_fb2d93be-f039-4d51-9150-108a10ee909f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7345.0" y="4295.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2767_sa4117" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="1838.0514" y="389.4311"/> <glyph class="unit of information" id="_ba1d81ec-333d-4c8d-b517-a41a2a366461"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1853.0514" y="384.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s2767_sa4256" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="3795.0" y="800.0"/> <glyph class="unit of information" id="_c4a7a5e0-5e2e-438c-878b-5c6c8ec676ee"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3810.0" y="795.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2767_sa5065" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="8130.0" y="3840.0"/> <glyph class="unit of information" id="_3473965f-2626-43b0-8d69-98aa594c6ec8"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8145.0" y="3835.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2768_sa510" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="cleaved~Caspase7*"/> <bbox w="80.0" h="40.0" x="7120.0" y="4680.0"/> <glyph class="unit of information" id="_216be8f6-fd90-4ac7-8221-5fcaca3ac534"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7135.0" y="4675.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2769_sa495" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase9*"/> <bbox w="80.0" h="40.0" x="3825.5" y="4225.877"/> <glyph class="unit of information" id="_34a36890-a7f7-4d23-ac42-2655efebd0be"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3840.5" y="4220.877"/> </glyph> </glyph> <glyph class="macromolecule" id="s2770_sa496" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="6980.0" y="5400.0"/> <glyph class="unit of information" id="_671e96c9-e77d-416e-9be2-8bb98a0e9160"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6995.0" y="5395.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2770_sa5067" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase9*"/> <clone/> <bbox w="80.0" h="40.0" x="8120.0" y="3900.0"/> <glyph class="unit of information" id="_144b2c06-5342-4e62-be7c-ee01d1f050f2"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8135.0" y="3895.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2772_sa1491" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="3333.8918" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s2774_sa1493" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:12003 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p73 HUGO:TP73 HGNC:12003 ENTREZ:7161 UNIPROT:O15350 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p73*"/> <bbox w="80.0" h="40.0" x="3452.5" y="7575.0"/> <glyph class="state variable" id="_8259088c-e9f9-467a-b6cf-29a1c6a494cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3504.0686" y="7570.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2777_sa1497" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <bbox w="90.0" h="25.0" x="4490.0" y="7052.5"/> <glyph class="unit of information" id="_83943228-d12b-41f2-bb9e-a3a74c7c385a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4525.0" y="7047.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2780_sa1500" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="Caspase8*"/> <bbox w="70.0" h="25.0" x="4812.0" y="7351.5"/> </glyph> <glyph class="complex" id="s2783_csa222" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BMF:MCL1 Identifiers_end </body> </html> </notes> <label text="BMF:MCL1"/> <bbox w="104.75" h="132.0" x="4877.625" y="4624.0"/> <glyph class="macromolecule" id="s2785_sa1688"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4890.0" y="4690.0"/> <glyph class="state variable" id="_7983ae2d-6bc0-43ef-aab8-cd224503ae56"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4944.9946" y="4685.0"/> </glyph> <glyph class="state variable" id="_4f281c95-3944-4440-97e6-1575ebfc2cf0"> <state value="?" variable="S159"/> <bbox w="35.0" h="10.0" x="4891.1646" y="4685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2784_sa1689"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="4889.625" y="4635.0"/> <glyph class="state variable" id="_fe2a0035-f6cf-4eb0-afca-f12d1f8c24a8"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4938.6934" y="4630.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2787_csa223" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:HRK Identifiers_end </body> </html> </notes> <label text="BCL2L1:HRK"/> <bbox w="100.0" h="125.0" x="4610.875" y="5107.0"/> <glyph class="macromolecule" id="s2791_sa1690"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="4620.875" y="5114.0"/> </glyph> <glyph class="macromolecule" id="s2790_sa1691"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <bbox w="80.0" h="40.0" x="4620.875" y="5164.0"/> </glyph> </glyph> <glyph class="complex" id="s2792_csa224" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2:HRK Identifiers_end </body> </html> </notes> <label text="BCL2:HRK"/> <bbox w="101.75" h="124.0" x="4609.125" y="4938.0"/> <glyph class="macromolecule" id="s2794_sa1692"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4621.125" y="4951.0"/> <glyph class="state variable" id="_bd14826f-a1f4-4471-8407-6d709a9f0c56"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4639.5566" y="4946.0"/> </glyph> <glyph class="state variable" id="_6db04117-7c04-42f5-8440-d676c8b0ee3e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4672.6934" y="4946.0"/> </glyph> <glyph class="state variable" id="_87ba6c56-32fc-42c4-a82f-51ff90f9d0f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4616.125" y="4966.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2793_sa1693"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <bbox w="80.0" h="40.0" x="4621.125" y="4995.0"/> </glyph> </glyph> <glyph class="complex" id="s2937_csa200" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BBC3:BCL2A1 Identifiers_end </body> </html> </notes> <label text="BBC3:BCL2A1"/> <bbox w="97.75" h="126.0" x="4602.25" y="4584.0"/> <glyph class="macromolecule" id="s3175_sa1644"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-related protein A1 HUGO:BCL2A1 HGNC:991 ENTREZ:597 UNIPROT:Q16548 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2A1"/> <bbox w="80.0" h="40.0" x="4610.0" y="4640.0"/> </glyph> <glyph class="macromolecule" id="s2993_sa1645"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="4614.25" y="4595.0"/> </glyph> </glyph> <glyph class="complex" id="s2938_csa202" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:BCL2L11 Identifiers_end </body> </html> </notes> <label text="BCL2L1:BCL2L11"/> <bbox w="100.75" h="125.0" x="4109.25" y="4345.0"/> <glyph class="macromolecule" id="s2964_sa1648"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="4119.25" y="4352.0"/> </glyph> <glyph class="macromolecule" id="s3136_sa1679"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4118.25" y="4398.0"/> <glyph class="state variable" id="_d0cbea02-c359-49f7-8fae-16deb91a7354"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4145.7817" y="4393.0"/> </glyph> <glyph class="state variable" id="_b5857abd-47b5-4f3d-9eeb-c42f3a0fa31c"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4185.75" y="4393.215"/> </glyph> <glyph class="state 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Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4114.125" y="4235.0"/> <glyph class="state variable" id="_13077527-d365-4f77-9f4e-c052f31926db"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4141.6567" y="4230.0"/> </glyph> <glyph class="state variable" id="_b3e9ab04-a27b-40a7-97a1-1ba1e2bae20a"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4181.625" y="4230.215"/> </glyph> <glyph class="state variable" id="_2282a506-025d-40d4-8c18-411f7abb885f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4165.9243" y="4270.0"/> </glyph> <glyph class="state variable" id="_8dd5ffcd-36f6-4286-aeef-29bbb18af160"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="4102.1177" y="4230.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2966_sa1650"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4117.125" y="4184.0"/> <glyph class="state variable" id="_a75d7258-a1eb-4642-b2b9-9bce579564be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4135.5566" y="4179.0"/> </glyph> 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<body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4605.25" y="4219.0"/> <glyph class="state variable" id="_a9b8ba22-ec8b-4232-9b26-d4e688c30d77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4623.6816" y="4214.0"/> </glyph> <glyph class="state variable" id="_87c4de73-7475-46fb-a341-5c64ecb14551"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4656.8184" y="4214.0"/> </glyph> <glyph class="state variable" id="_4b2c1097-8a68-4936-92cd-71a893d6ff5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4600.25" y="4234.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s35_sa1653"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="4604.25" y="4169.0"/> </glyph> </glyph> <glyph class="complex" id="s2942_csa206" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2A1:cleaved_BID* Identifiers_end </body> </html> </notes> <label text="BCL2A1:tBID"/> <bbox w="103.75" h="120.0" x="4336.25" y="4610.0"/> <glyph class="macromolecule" id="s2943_sa1656"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-related protein A1 HUGO:BCL2A1 HGNC:991 ENTREZ:597 UNIPROT:Q16548 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2A1"/> <bbox w="80.0" h="40.0" x="4346.25" y="4619.0"/> </glyph> <glyph class="macromolecule" id="s8061_sa1663"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="4350.0" y="4670.0"/> <glyph class="state variable" id="_d65afdce-1f08-445a-a061-903d328266c4"> <state value="My" variable=""/> <bbox w="20.0" h="10.0" x="4364.216" y="4705.0"/> </glyph> <glyph class="unit of information" id="_ea4e968e-e0d7-48f9-9422-969df6a78240"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4365.0" y="4665.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2945_csa207" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2:cleaved_BID* Identifiers_end </body> </html> </notes> <label text="BCL2:tBID"/> <bbox w="97.75" h="125.0" x="4332.25" y="4185.0"/> <glyph class="macromolecule" id="s21_sa1658"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4342.25" y="4197.0"/> <glyph class="state variable" id="_6009154f-6909-499a-8b0d-4c1e0cb76c75"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4360.6816" y="4192.0"/> </glyph> <glyph class="state variable" id="_48a9484e-db00-4b38-8091-cd0ffbb3e3ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4393.8184" y="4192.0"/> </glyph> <glyph class="state variable" id="_f6b7b1da-2c2f-459a-af4b-f374dbcfeaa0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4337.25" y="4212.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s20_sa1659"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="4340.0" y="4240.0"/> <glyph class="state variable" id="_46deacdc-b6c2-44e1-bfe5-39e99f94970d"> <state value="My" variable=""/> <bbox w="20.0" h="10.0" x="4354.216" y="4275.0"/> </glyph> <glyph class="unit of information" id="_97df7a03-97a2-42b9-b5f1-2f822f1878bd"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4355.0" y="4235.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2946_csa209" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:cleaved_BID* Identifiers_end </body> </html> </notes> <label text="BCL2L1:tBID"/> <bbox w="105.75" h="120.0" x="4334.25" y="4340.0"/> <glyph class="macromolecule" id="s2972_sa1662"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="4344.25" y="4353.0"/> </glyph> <glyph class="macromolecule" id="s3133_sa1677"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="4350.0" y="4390.0"/> <glyph class="state variable" id="_c60953bb-4dab-4d3c-be65-6667e8b150cc"> <state value="My" variable=""/> <bbox w="20.0" h="10.0" x="4364.216" y="4425.0"/> </glyph> <glyph class="unit of information" id="_fc5c85db-60f9-4318-810f-cf646e90b737"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4365.0" y="4385.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2947_csa210" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BBC3:MCL1 Identifiers_end </body> </html> </notes> <label text="BBC3:MCL1"/> <bbox w="100.0" h="120.0" x="4610.0" y="4730.0"/> <glyph class="macromolecule" id="s3174_sa1664"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4620.0" y="4790.0"/> <glyph class="state variable" id="_8f55d195-1367-4781-8e72-5eefe83cc713"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4674.9946" y="4785.0"/> </glyph> <glyph class="state variable" id="_b234d42e-5ed3-41e2-8a7a-d72056d6f477"> <state value="?" variable="S159"/> <bbox w="35.0" h="10.0" x="4621.1646" y="4785.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2997_sa1665"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="4622.0" y="4739.0"/> </glyph> </glyph> <glyph class="complex" id="s2948_csa211" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:BCL2L2 Identifiers_end </body> </html> </notes> <label text="BCL2L11:BCL2L2"/> <bbox w="95.75" h="122.0" x="4114.25" y="4478.0"/> <glyph class="macromolecule" id="s8062_sa1666"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="4120.0" y="4530.0"/> </glyph> <glyph class="macromolecule" id="s2998_sa1667"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4123.25" y="4489.0"/> <glyph class="state variable" id="_a21ec29d-a760-4c46-b1f9-4f928e7f0abe"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4150.7817" y="4484.0"/> </glyph> <glyph class="state variable" id="_d50c3482-ac01-44ac-bfef-ab20e52f5cec"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4190.75" y="4484.215"/> </glyph> <glyph class="state variable" id="_35d0e6ba-2a1f-41a9-99e5-5001c4ada00f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4175.0493" y="4524.0"/> </glyph> <glyph class="state variable" id="_89ae19b6-666b-4833-bdae-9193b3be509f"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="4111.2427" y="4484.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2949_csa212" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:MCL1 Identifiers_end </body> </html> </notes> <label text="BCL2L11:MCL1"/> <bbox w="97.75" h="122.0" x="4112.25" y="4748.0"/> <glyph class="macromolecule" id="s2978_sa1668"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4120.0" y="4810.0"/> <glyph class="state variable" id="_09e88123-2da1-4870-8078-01bef516fadf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4174.9946" y="4805.0"/> </glyph> <glyph class="state variable" id="_34eaf706-7bc4-485c-ae0d-57b04da61d68"> <state value="" variable="S159"/> <bbox w="30.0" h="10.0" x="4123.6646" y="4805.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2999_sa1669"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4121.0" y="4764.0"/> <glyph class="state variable" id="_527cf29f-97f6-4cf1-811c-bb6a30720455"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4148.5317" y="4759.0"/> </glyph> <glyph class="state variable" id="_288d2586-be3c-4d77-b329-249ac00494ac"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4188.5" y="4759.215"/> </glyph> <glyph class="state variable" id="_149fa82c-e023-4b66-8f1e-70b53fc6de8e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4172.7993" y="4799.0"/> </glyph> <glyph class="state variable" id="_966cf5f6-6e46-4f4d-a532-0d81a62224e0"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="4108.9927" y="4759.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2950_csa213" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MCL1:PMAIP1 Identifiers_end </body> </html> </notes> <label text="MCL1:PMAIP1"/> <bbox w="99.75" h="124.0" x="4220.25" y="5376.0"/> <glyph class="macromolecule" id="s2981_sa1670"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4231.5" y="5390.0"/> <glyph class="state variable" id="_7da2d25e-8425-4e85-b94a-f50403fbc3bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4286.4946" y="5385.0"/> </glyph> <glyph class="state variable" id="_f378e302-8224-4a0e-8146-a96fa236f5d3"> <state value="?" variable="S159"/> <bbox w="35.0" h="10.0" x="4232.6646" y="5385.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3137_sa1671"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:NOXA References_end </body> </html> </notes> <label text="PMAIP1"/> <bbox w="80.0" h="40.0" x="4230.25" y="5433.0"/> </glyph> </glyph> <glyph class="complex" id="s2951_csa214" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2 Identifiers_end </body> </html> </notes> <label text="BAD:BCL2"/> <bbox w="98.0" h="122.0" x="5581.0" y="4189.0"/> <glyph class="macromolecule" id="s2983_sa1672"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5589.25" y="4249.3335"/> <glyph class="state variable" id="_0cf6fc9c-311a-41eb-ae7f-3a7e3f25671f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5607.6816" y="4244.3335"/> </glyph> <glyph class="state variable" id="_0c8b9d23-0b23-4367-8912-95ca6401f46c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5640.8184" y="4244.3335"/> </glyph> <glyph class="state variable" id="_2cbf5917-7521-4f56-9092-520c6153d7fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5584.25" y="4264.3335"/> </glyph> </glyph> <glyph class="macromolecule" id="s3000_sa1673"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="5591.0" y="4198.3335"/> <glyph class="state variable" id="_6fe973f7-67f7-41ec-a71f-d2d11b599997"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5609.595" y="4193.3335"/> </glyph> <glyph class="state variable" id="_f3d39b13-95bf-4184-b6f4-7912673f29d8"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="5632.949" y="4193.3335"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2952_csa215" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2-XL* Identifiers_end </body> </html> </notes> <label text="BAD:BCL2L1"/> <bbox w="102.0" h="118.0" x="5581.0" y="4333.0"/> <glyph class="macromolecule" id="s8064_sa1674"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="5590.0" y="4390.0"/> </glyph> <glyph class="macromolecule" id="s3001_sa1675"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="4350.0" y="4480.0"/> <glyph class="state variable" id="_5dd3e053-0f62-4c0c-844c-049ac2a06cc4"> <state value="My" variable=""/> <bbox w="20.0" h="10.0" x="4364.216" y="4515.0"/> </glyph> <glyph class="unit of information" id="_1507f564-58d3-44b1-bde3-cf139c6792eb"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4365.0" y="4475.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2954_sa1676"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="4350.0" y="4530.0"/> </glyph> </glyph> <glyph class="complex" id="s2955_csa217" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2A1:BCL2L11 Identifiers_end </body> </html> </notes> <label text="BCL2A1:BCL2L11"/> <bbox w="103.75" h="120.0" x="4116.25" y="4610.0"/> <glyph class="macromolecule" id="s4210_sa1678"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-related protein A1 HUGO:BCL2A1 HGNC:991 ENTREZ:597 UNIPROT:Q16548 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2A1"/> <bbox w="80.0" h="40.0" x="4126.25" y="4623.0"/> </glyph> <glyph class="macromolecule" id="s8060_sa1696"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4130.0" y="4670.0"/> <glyph class="state variable" id="_53f66ed5-e75c-4d66-a115-f936163d0f2d"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4157.5317" y="4665.0"/> </glyph> <glyph class="state variable" id="_2a12f11d-337c-43c6-9146-1bee2cd6d32b"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4197.5" y="4665.215"/> </glyph> <glyph class="state variable" id="_811f97b6-223a-407b-8593-60916db99144"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4181.7993" y="4705.0"/> </glyph> <glyph class="state variable" id="_6d3621f7-f0fe-4c76-aee6-0d61da5c0fbb"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="4117.9927" y="4665.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2957_csa218" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MCL1:cleaved_BID* Identifiers_end </body> </html> </notes> <label text="MCL1:tBID"/> <bbox w="100.0" h="120.0" x="4330.0" y="4770.0"/> <glyph class="macromolecule" id="s7613_sa1680"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4342.0" y="4782.0"/> <glyph class="state variable" id="_cc538b05-cc39-41cf-870a-07e73f89dc5d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4396.9946" y="4777.0"/> </glyph> <glyph class="state variable" id="_fd22cfc1-1a33-49a6-be2a-a325ac2c0319"> <state value="?" variable="S159"/> <bbox w="35.0" h="10.0" x="4343.1646" y="4777.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2944_sa1681"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved_BID*"/> <bbox w="80.0" h="40.0" x="4342.0" y="4825.0"/> <glyph class="state variable" 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B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4877.5" y="4189.0"/> <glyph class="state variable" id="_e55232b7-1b43-45db-827c-b003cb3213dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4895.9316" y="4184.0"/> </glyph> <glyph class="state variable" id="_3769d6b1-e1d2-46d0-ac52-43e6770a7dbb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4929.0684" y="4184.0"/> </glyph> <glyph class="state variable" id="_2b14148e-492c-4816-8e76-f2e63e42d98d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4872.5" y="4204.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3002_sa1683"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="4880.25" y="4237.0"/> <glyph class="state variable" id="_648de531-bd87-4696-a158-8351520555aa"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4929.3184" y="4232.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2959_csa220" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:BMF Identifiers_end </body> </html> </notes> <label text="BCL2L1:BMF"/> <bbox w="103.75" h="128.0" x="4866.25" y="4332.0"/> <glyph class="macromolecule" id="s2990_sa1684"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="4875.5" y="4346.0"/> </glyph> <glyph class="macromolecule" id="s3003_sa1687"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="4876.25" y="4391.0"/> <glyph class="state variable" id="_799b64b0-2cca-43d8-8fb3-31160735126e"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4925.3184" y="4386.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2960_csa221" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L2:BMF Identifiers_end </body> </html> </notes> <label text="BCL2L2:BMF"/> <bbox w="101.75" h="118.0" x="4868.25" y="4472.0"/> <glyph class="macromolecule" id="s8063_sa1685"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="4880.0" y="4530.0"/> <glyph class="state variable" id="_8e85ce25-cfcf-4cea-ad8d-4ad2585aa8e8"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4929.0684" y="4525.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2782_sa1686"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="4877.5" y="4478.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3006_sa1630" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="4221.25" y="4109.0"/> <glyph class="state variable" id="_bbe33f61-d731-45c4-a4e6-a600acb86ad7"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="4248.7817" y="4104.0"/> </glyph> <glyph class="state variable" id="_0a5d7a43-e9fd-4d25-bf43-cb649061b083"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="4288.75" y="4104.215"/> </glyph> <glyph class="state variable" id="_f6b013d6-7ab2-436d-b104-bfe55a9b81b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4273.0493" y="4144.0"/> </glyph> <glyph class="state variable" id="_ee8ff9d8-ce8d-4c5f-b108-ca64e3c662d4"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="4209.2427" y="4104.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3007_sa1632" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="4740.0" y="4090.0"/> </glyph> <glyph class="macromolecule" id="s3008_sa1634" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:NOXA References_end </body> </html> </notes> <label text="PMAIP1"/> <bbox w="80.0" h="40.0" x="4350.0" y="5540.0"/> </glyph> <glyph class="macromolecule" id="s3009_sa1636" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="5360.0" y="4360.0"/> </glyph> <glyph class="macromolecule" id="s3010_sa1637" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 2 HUGO:BCL2L2 HGNC:995 ENTREZ:599 UNIPROT:Q92843 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL-W References_end </body> </html> </notes> <label text="BCL2L2"/> <bbox w="80.0" h="40.0" x="5360.0" y="4480.0"/> </glyph> <glyph class="macromolecule" id="s3011_sa1638" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-related protein A1 HUGO:BCL2A1 HGNC:991 ENTREZ:597 UNIPROT:Q16548 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BCL2A1"/> <bbox w="80.0" h="40.0" x="5370.0" y="4620.0"/> </glyph> <glyph class="macromolecule" id="s3012_sa1640" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="5030.0" y="4090.0"/> <glyph class="state variable" id="_3ff180c6-c77a-47ab-8961-5246be7f6c13"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="5079.0684" y="4085.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3013_sa1641" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <bbox w="80.0" h="40.0" x="4770.0" y="4900.0"/> </glyph> <glyph class="complex" id="s3084_csa108" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFE2L2:small~MAF* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NFE2L2:small_Maf"/> <bbox w="100.0" h="120.0" x="7272.5" y="7565.0"/> <glyph class="macromolecule" id="s3085_sa1240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <bbox w="80.0" h="40.0" x="7277.5" y="7578.0"/> <glyph class="state variable" id="_6b1db765-e055-41f7-8dfd-81281bc35ba8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7329.0684" y="7573.0"/> </glyph> <glyph class="state variable" id="_1d72bf9c-88af-4987-bf03-5379e6e2822d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7295.9316" y="7573.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3086_sa1241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: genetic entity References_end </body> </html> </notes> <label text="small~MAF*"/> <bbox w="80.0" h="40.0" x="7279.5" y="7627.0"/> </glyph> </glyph> <glyph class="complex" id="s3089_csa227" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BCL2 Identifiers_end </body> </html> </notes> <label text="BAX:BCL2"/> <bbox w="100.0" h="120.0" x="4290.0" y="5830.0"/> <glyph class="macromolecule" id="s6279_sa1701"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4299.943" y="5839.5034"/> <glyph class="state variable" id="_7f2a86db-d753-4982-a493-3c4bbf63ee49"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4298.52" y="5834.5034"/> </glyph> <glyph class="state variable" id="_a3bf2f87-4de3-4661-b7f2-71dbbaef9e91"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4343.5273" y="5834.5034"/> </glyph> <glyph class="state variable" id="_5594d74b-9cf5-4775-82fd-71a22163f92e"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4346.264" y="5874.5034"/> </glyph> </glyph> <glyph class="macromolecule" id="s6280_sa1702"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4297.943" y="5887.421"/> <glyph class="state variable" id="_e8a422b9-d98d-4f48-a1bc-3654565e7ed8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4316.3745" y="5882.421"/> </glyph> <glyph class="state variable" id="_72452883-925b-4282-ba7e-568dace578c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4349.511" y="5882.421"/> </glyph> <glyph class="state variable" id="_bb40b430-7aa8-483b-bbfb-9b2f38796417"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4292.943" y="5902.421"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3092_sa1703" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: early growth response 2 HUGO:EGR2 HGNC:3239 ENTREZ:1959 UNIPROT:P11161 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="EGR2"/> <bbox w="80.0" h="40.0" x="7562.5" y="7385.0"/> </glyph> <glyph class="macromolecule" id="s3094_sa1705" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="5400.0" y="5520.0"/> </glyph> <glyph class="nucleic acid feature" id="s3095_sa1706" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BAK1"/> <bbox w="70.0" h="25.0" x="7483.977" y="7303.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3096_sa1707" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BAK1"/> <bbox w="90.0" h="25.0" x="7642.5" y="7080.5"/> <glyph class="unit of information" id="_aa5e0cd6-6ec1-480c-a20c-5bd2ed7ecd29"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7677.5" y="7075.5"/> </glyph> </glyph> <glyph class="complex" id="s3097_csa228" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HRK:MCL1 Identifiers_end </body> </html> </notes> <label text="HRK:MCL1"/> <bbox w="103.75" h="120.0" x="4619.0" y="5272.0"/> <glyph class="macromolecule" id="s3099_sa1708"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <bbox w="80.0" h="40.0" x="4632.262" y="5287.5386"/> </glyph> <glyph class="macromolecule" id="s3098_sa1709"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="4631.262" y="5331.5386"/> <glyph class="state variable" id="_1118ace7-a79e-456d-bf20-3a59d38f31e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4686.257" y="5326.5386"/> </glyph> <glyph class="state variable" id="_dcb2a2fe-ad36-44a2-b8d9-fdc6b1ce552e"> <state value="?" variable="S159"/> <bbox w="35.0" h="10.0" x="4632.427" y="5326.5386"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3100_sa1710" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: complement component 1, q subcomponent binding protein HUGO:C1QBP HGNC:1243 ENTREZ:708 UNIPROT:Q07021 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="C1QBP"/> <bbox w="80.0" h="40.0" x="4900.0" y="3850.0"/> </glyph> <glyph class="macromolecule" id="s3101_sa1712" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kv channel interacting protein 3, calsenilin HUGO:KCNIP3 HGNC:15523 ENTREZ:30818 UNIPROT:Q9Y2W7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:DREAM References_end </body> </html> </notes> <label text="KCNIP3"/> <bbox w="80.0" h="40.0" x="4974.0" y="7778.0"/> <glyph class="state variable" id="_c1f3ae21-3e28-49f7-9262-645e524499ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5025.5684" y="7773.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3104_sa1715" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kv channel interacting protein 3, calsenilin HUGO:KCNIP3 HGNC:15523 ENTREZ:30818 UNIPROT:Q9Y2W7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="cleaved~KCNIP3*"/> <bbox w="80.0" h="40.0" x="4974.0" y="7898.0"/> <glyph class="unit of information" id="_695389a0-737c-494d-b5d1-64b348fdeb6f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4989.0" y="7893.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3130_sa1744" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pim-2 oncogene HUGO:PIM2 HGNC:8987 ENTREZ:11040 UNIPROT:Q9P1W9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PIM2"/> <bbox w="80.0" h="40.0" x="2751.25" y="2735.6084"/> </glyph> <glyph class="macromolecule" id="s3141_sa3052" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenylate kinase 1 HUGO:AK1 HGNC:361 ENTREZ:203 UNIPROT:P00568 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS Maps_Modules_end </body> </html> </notes> <label text="AK1"/> <bbox w="80.0" h="40.0" x="6050.0" y="5760.0"/> </glyph> <glyph class="macromolecule" id="s3142_sa1743" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pim-1 oncogene HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PIM1"/> <bbox w="80.0" h="40.0" x="2751.25" y="2687.6084"/> </glyph> <glyph class="macromolecule" id="s3143_sa1746" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pim-3 oncogene HUGO:PIM3 HGNC:19310 ENTREZ:415116 UNIPROT:Q86V86 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="PIM3"/> <bbox w="80.0" h="40.0" x="2753.25" y="2783.6084"/> </glyph> <glyph class="macromolecule" id="s3146_sa1749" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="3150.0" y="2930.0"/> <glyph class="state variable" id="_a0a0f922-645c-4914-866b-d3a52310ae2d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3166.095" y="2925.0"/> </glyph> <glyph class="state variable" id="_2a679680-45df-43ae-8905-694408303c0d"> <state value="" variable="S91"/> <bbox w="25.0" h="10.0" x="3194.4492" y="2925.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3147_sa1754" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="3068.75" y="3052.3916"/> <glyph class="state variable" id="_bb6c52d5-8285-4a24-9d18-328cb264aee4"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3084.845" y="3047.3916"/> </glyph> <glyph class="state variable" id="_920995e7-73b6-48f2-bf3a-3bc43da5ce00"> <state value="" variable="S91"/> <bbox w="25.0" h="10.0" x="3113.1992" y="3047.3916"/> </glyph> </glyph> <glyph class="macromolecule" id="s3148_sa4466" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <clone/> <bbox w="80.0" h="40.0" x="9942.5" y="1852.5"/> <glyph class="state variable" id="_16af3eca-c775-4f1d-ba13-29198208ec50"> <state value="active" variable=""/> <bbox w="40.0" h="10.0" x="9962.5" y="1847.5"/> </glyph> <glyph class="state variable" id="_c1f5df04-c9ff-4b48-93cf-e0d774b0ddfd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9961.095" y="1847.5"/> </glyph> <glyph class="state variable" id="_94e457f4-4d5e-417e-8d89-1d53eb5473c3"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="9984.449" y="1847.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3148_sa5385" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <clone/> <bbox w="80.0" h="40.0" x="3090.0" y="3250.0"/> <glyph class="state variable" id="_b35a3500-4f12-4178-9925-9f17cdbc5e8c"> <state value="active" variable=""/> <bbox w="40.0" h="10.0" x="3110.0" y="3245.0"/> </glyph> <glyph class="state variable" id="_dc43829d-2446-439b-b5a0-0b045258d069"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3108.595" y="3245.0"/> </glyph> <glyph class="state variable" id="_ff83c4c0-1a11-4cb5-9e68-9654e91736ba"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="3131.9492" y="3245.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3149_sa1758" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="3034.5" y="3160.1416"/> <glyph class="state variable" id="_0e91f308-2569-4dfa-9539-22d37c0c4222"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3050.595" y="3155.1416"/> </glyph> <glyph class="state variable" id="_4c785074-8f8d-4c19-9f82-1e1e2f5728d5"> <state value="P" variable="S91"/> <bbox w="30.0" h="10.0" x="3076.4492" y="3155.1416"/> </glyph> </glyph> <glyph class="complex" id="s3150_csa234" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD Identifiers_end </body> </html> </notes> <label text="14-3-3:BAD_P"/> <bbox w="100.0" h="120.0" x="3250.0" y="3060.0"/> <glyph class="macromolecule" id="s3151_sa1762"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="3262.18" y="3068.3499"/> <glyph class="state variable" id="_bb7d8cb7-e536-4eb5-9386-3594c4448324"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3311.2778" y="3063.3499"/> </glyph> </glyph> <glyph class="macromolecule" id="s3155_sa1767"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="3259.75" y="3116.8584"/> <glyph class="state variable" id="_97b53b64-42fd-47a2-855d-7f0ee4f9e6a1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3275.845" y="3111.8584"/> </glyph> <glyph class="state variable" id="_ae61a10a-e59c-401b-a198-a4e80299bbbe"> <state value="" variable="S91"/> <bbox w="25.0" h="10.0" x="3304.1992" y="3111.8584"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3156_sa1768" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 1, catalytic subunit, alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 protein phosphatase 1, catalytic subunit, beta isozyme HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 protein phosphatase 1, catalytic subunit, gamma isozyme HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: catalytic subunit of phosphatase PP1A, PP1c 3 genes encode 3 isoforms References_end </body> </html> </notes> <label text="PPP1C*"/> <bbox w="80.0" h="40.0" x="2690.0" y="2550.0"/> </glyph> <glyph class="macromolecule" id="s3157_sa1769" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: There are 3 different genes that code for PKA catalytic subunits References_end </body> </html> </notes> <label text="PRKAC*"/> <bbox w="80.0" h="40.0" x="2606.0" y="2550.0"/> </glyph> <glyph class="macromolecule" id="s3158_sa1770" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WAS protein family, member 1 HUGO:WASF1 HGNC:12732 ENTREZ:8936 UNIPROT:Q92558 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="WASF1"/> <bbox w="80.0" h="40.0" x="2522.0" y="2550.0"/> </glyph> <glyph class="complex" id="s3179_csa236" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:GCK:PPP1C*:PRKAC*:WASF1 Identifiers_end </body> </html> </notes> <label text="BAD_P:WASF1:GCK:PRKAC:PPP1C"/> <bbox w="180.0" h="168.0" x="4310.0" y="3856.0"/> <glyph class="macromolecule" id="s3164_sa1777"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: WAS protein family, member 1 HUGO:WASF1 HGNC:12732 ENTREZ:8936 UNIPROT:Q92558 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="WASF1"/> <bbox w="80.0" h="40.0" x="4318.0" y="3956.0"/> </glyph> <glyph class="macromolecule" id="s3166_sa1778"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glucokinase (hexokinase 4) HUGO:GCK HGNC:4195 ENTREZ:2645 UNIPROT:P35557 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GCK"/> <bbox w="80.0" h="40.0" x="4316.0" y="3864.0"/> </glyph> <glyph class="macromolecule" id="s3168_sa1779"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="4318.0" y="3912.0"/> <glyph class="state variable" id="_f3015d5e-9070-4ba7-83cb-fc673bc261e9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4334.095" y="3907.0"/> </glyph> <glyph class="state variable" id="_2eaddfdb-cd90-4b4b-a7c5-79d6b2692c52"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="4359.949" y="3907.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s53_sa1780"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 1, catalytic subunit, alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 protein phosphatase 1, catalytic subunit, beta isozyme HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 protein phosphatase 1, catalytic subunit, gamma isozyme HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: catalytic subunit of phosphatase PP1A, PP1c 3 genes encode 3 isoforms References_end </body> </html> </notes> <label text="PPP1C*"/> <bbox w="80.0" h="40.0" x="4402.0" y="3912.0"/> </glyph> <glyph class="macromolecule" id="s54_sa1781"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: There are 3 different genes that code for PKA catalytic subunits References_end </body> </html> </notes> <label text="PRKAC*"/> <bbox w="80.0" h="40.0" x="4402.0" y="3864.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3181_sa1451" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22427918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:23301705 PMID:28574505 References_end </body> </html> </notes> <label text="cleaved~Caspase8*"/> <clone/> <bbox w="80.0" h="40.0" x="7440.0" y="4090.0"/> <glyph class="unit of information" id="_2844bde6-b455-43f2-82d5-fbcdd12640e6"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7455.0" y="4085.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3181_sa3919" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22427918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:23301705 PMID:28574505 References_end </body> </html> </notes> <label text="cleaved~Caspase8*"/> <clone/> <bbox w="80.0" h="40.0" x="6920.0" y="1000.0"/> <glyph class="unit of information" id="_b913b368-5002-46d9-9aa6-4c88c8a98b7d"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6935.0" y="995.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3182_sa1790" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="6920.0" y="3060.0"/> <glyph class="state variable" id="_43afa730-9971-40e0-a310-4ee5c793dcf0"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6933.4316" y="3055.0"/> </glyph> <glyph class="state variable" id="_fca2f7d9-c69d-4f8e-bc49-ad2490be643d"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="6964.449" y="3055.0"/> </glyph> </glyph> <glyph class="source and sink" id="s3183_sa1791" compartmentRef="c1_ca1"> <label text="s3183"/> <bbox w="30.0" h="30.0" x="6775.0" y="3065.0"/> </glyph> <glyph class="simple chemical" id="s3184_sa1792" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29806 KEGGCOMPOUND:C00122 CAS:142-42-7 Identifiers_end </body> </html> </notes> <label text="fumarate"/> <bbox w="70.0" h="25.0" x="889.26306" y="5560.75"/> </glyph> <glyph class="macromolecule" id="s3185_sa1793" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: fumarate hydratase HUGO:FH HGNC:3700 ENTREZ:2271 UNIPROT:P07954 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:fumarate hydratase synonym:fumarase References_end </body> </html> </notes> <label text="FH"/> <bbox w="80.0" h="40.0" x="997.26306" y="5482.75"/> </glyph> <glyph class="simple chemical" id="s3188_sa1796" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16087 KEGGCOMPOUND:C00311 Identifiers_end </body> </html> </notes> <label text="isocitrate"/> <bbox w="70.0" h="25.0" x="1161.2631" y="5769.75"/> </glyph> <glyph class="simple chemical" id="s3189_sa1797" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16947 KEGGCOMPOUND:C00158 CAS:126-44-3 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="citrate"/> <bbox w="70.0" h="25.0" x="1335.0" y="5767.5"/> </glyph> <glyph class="macromolecule" id="s3190_sa1798" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ELK1, member of ETS oncogene family HUGO:ELK1 HGNC:3321 ENTREZ:2002 UNIPROT:P19419 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ELK1"/> <bbox w="80.0" h="40.0" x="3282.5" y="7475.0"/> </glyph> <glyph class="macromolecule" id="s3192_sa1800" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="cleaved~IKBKB*"/> <bbox w="80.0" h="40.0" x="5317.0" y="1317.0"/> <glyph class="unit of information" id="_23c75f1b-e488-4fe0-b98d-dd20cbe763dd"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5332.0" y="1312.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3196_sa1805" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol 3-kinase, catalytic subunit type 3 HUGO:PIK3C3 HGNC:8974 ENTREZ:5289 UNIPROT:Q8NEB9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="PIK3C3"/> <bbox w="80.0" h="40.0" x="10214.5" y="2621.5"/> </glyph> <glyph class="macromolecule" id="s3198_sa1806" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol 3-kinase, catalytic subunit type 3 HUGO:PIK3C3 HGNC:8974 ENTREZ:5289 UNIPROT:Q8NEB9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="cleaved~PIK3C3*"/> <bbox w="80.0" h="40.0" x="10421.0" y="2678.5"/> <glyph class="unit of information" id="_22414c61-08b9-474e-913f-afb7a4060947"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10436.0" y="2673.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3199_sa1807" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="cleaved~BECN1*"/> <bbox w="80.0" h="40.0" x="10272.5" y="2462.5"/> <glyph class="unit of information" id="_f7d65633-36e2-4d66-86e1-7b4211eaf1a1"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10287.5" y="2457.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3200_sa1808" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="cleaved~BECN1*"/> <bbox w="80.0" h="40.0" x="5120.0" y="6005.0"/> <glyph class="unit of information" id="_d46d0a8a-131b-4172-85aa-a4867f310904"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5135.0" y="6000.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3201_sa1809" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HCLS1 associated protein X-1 HUGO:HAX1 HGNC:16915 ENTREZ:10456 UNIPROT:O00165 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="cleaved~HAX1*"/> <bbox w="80.0" h="40.0" x="3680.0" y="3890.0"/> <glyph class="unit of information" id="_e2415d61-da08-4cf5-a417-80135d0f1c14"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3695.0" y="3885.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3204_sa1813" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 2, apoptosis-related cysteine peptidase HUGO:CASP2 HGNC:1503 ENTREZ:835 UNIPROT:P42575 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase2*"/> <bbox w="80.0" h="40.0" x="3821.0" y="4045.0"/> <glyph class="state variable" id="_025e21ea-640b-4c7d-adf8-885c6c69d022"> <state value="" variable="S122"/> <bbox w="30.0" h="10.0" x="3862.9492" y="4040.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3205_sa1816" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: diablo, IAP-binding mitochondrial protein HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DIABLO"/> <bbox w="80.0" h="40.0" x="7390.0" y="3760.0"/> <glyph class="state variable" id="_e15c7a1f-27fb-4fdc-a8d8-d03c5ea906bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7441.5684" y="3755.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3206_sa1817" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: diablo, IAP-binding mitochondrial protein HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DIABLO"/> <bbox w="80.0" h="40.0" x="3815.0" y="3876.0"/> <glyph class="state variable" id="_47398a7a-971a-42a7-bfff-ca6ecd951806"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3866.5686" y="3871.0"/> </glyph> </glyph> <glyph class="complex" id="s3207_csa240" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase3*:HSPB1 Identifiers_end </body> </html> </notes> <label text="CASP3:HSPB1"/> <bbox w="103.083824" h="120.526344" x="6748.458" y="4249.737"/> <glyph class="macromolecule" id="s3208_sa1818"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock 27kDa protein 1 HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:HSP27PMID:11003656 References_end </body> </html> </notes> <label text="HSPB1"/> <bbox w="80.0" h="40.0" x="6761.542" y="4303.263"/> </glyph> <glyph class="macromolecule" id="s3209_sa1819"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <bbox w="80.0" h="40.0" x="6759.542" y="4259.263"/> </glyph> </glyph> <glyph class="macromolecule" id="s3210_sa1820" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 6 HUGO:BIRC6 HGNC:13516 ENTREZ:57448 UNIPROT:Q9NR09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="BIRC6"/> <bbox w="80.0" h="40.0" x="6471.0" y="5043.0"/> <glyph class="state variable" id="_816bc0e3-1cf7-4cb3-beb3-7675ae228964"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6522.5684" y="5038.0"/> </glyph> </glyph> <glyph class="source and sink" id="s3211_sa1821" compartmentRef="c1_ca1"> <label text="s3211"/> <bbox w="30.0" h="30.0" x="7735.0" y="3765.0"/> </glyph> <glyph class="macromolecule" id="s3212_sa1822" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: diablo, IAP-binding mitochondrial protein HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DIABLO"/> <bbox w="80.0" h="40.0" x="7570.0" y="3760.0"/> <glyph class="state variable" id="_f7e029f2-6f3d-4908-98bd-e6f174321959"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7616.5684" y="3755.0"/> </glyph> </glyph> <glyph class="source and sink" id="s3213_sa1826" compartmentRef="c1_ca1"> <label text="s3213"/> <bbox w="30.0" h="30.0" x="6287.625" y="5134.875"/> </glyph> <glyph class="macromolecule" id="s3214_sa1824" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6357.625" y="5128.875"/> <glyph class="state variable" id="_f3200593-2116-4abd-8890-c474f5a0da5e"> <state value="?" variable="T125"/> <bbox w="35.0" h="10.0" x="6363.72" y="5123.875"/> </glyph> <glyph class="state variable" id="_195e9034-60c1-4e24-b07e-c4321d1fe804"> <state value="?" variable="S196"/> <bbox w="35.0" h="10.0" x="6397.074" y="5123.875"/> </glyph> <glyph class="state variable" id="_3db8e65f-73bb-4b2d-a6bb-8dbcc6c91381"> <state value="?" variable="Y153"/> <bbox w="35.0" h="10.0" x="6396.4556" y="5163.875"/> </glyph> <glyph class="state variable" id="_42a8bb81-8982-4ab8-bb3f-a7fded7dd51a"> <state value="?" variable="S144"/> <bbox w="35.0" h="10.0" x="6363.1006" y="5163.875"/> </glyph> <glyph class="state variable" id="_36458b6e-f82e-47fb-8949-865949d17b3a"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="6425.125" y="5143.875"/> </glyph> <glyph class="state variable" id="_fdd4e473-6a39-4b55-a057-50b42eb003cc"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6347.625" y="5143.875"/> </glyph> </glyph> <glyph class="macromolecule" id="s3215_sa1827" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 6 HUGO:BIRC6 HGNC:13516 ENTREZ:57448 UNIPROT:Q9NR09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="cleaved~BIRC6"/> <bbox w="80.0" h="40.0" x="6325.0" y="5045.0"/> <glyph class="unit of information" id="_67c08d16-4208-494a-bfbd-bed700721230"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6340.0" y="5040.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3216_sa1828" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 41 HUGO:RNF41 HGNC:18401 ENTREZ:10193 UNIPROT:Q9H4P4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="RNF41"/> <bbox w="80.0" h="40.0" x="6570.0" y="4950.0"/> </glyph> <glyph class="macromolecule" id="s3217_sa1829" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 6 HUGO:BIRC6 HGNC:13516 ENTREZ:57448 UNIPROT:Q9NR09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="BIRC6"/> <bbox w="80.0" h="40.0" x="6470.0" y="4870.0"/> <glyph class="state variable" id="_67c47369-7358-47fb-8d00-e42a609428ef"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6516.5684" y="4865.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3224_sa1834" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: XIAP associated factor 1 HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="XAF1"/> <bbox w="80.0" h="40.0" x="4822.5" y="7615.0"/> </glyph> <glyph class="complex" id="s3225_csa242" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:XAF1:XIAP Identifiers_end </body> </html> </notes> <label text="XAF1:XIAP"/> <bbox w="100.0" h="120.0" x="4972.5" y="7605.0"/> <glyph class="macromolecule" id="s3227_sa1835"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: XIAP associated factor 1 HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="XAF1"/> <bbox w="80.0" h="40.0" x="4982.198" y="7660.387"/> </glyph> <glyph class="macromolecule" id="s3226_sa1836"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="4982.198" y="7620.387"/> <glyph class="state variable" id="_a49085d9-c761-4e6e-9eeb-70428ab6e947"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5000.63" y="7615.387"/> </glyph> <glyph class="state variable" id="_f999dad4-64a4-47a2-aa9f-0004ff622760"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="5024.1475" y="7615.387"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3228_sa1837" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: F-box protein 45 HUGO:FBXO45 HGNC:29148 ENTREZ:200933 UNIPROT:P0C2W1 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FBXO45"/> <bbox w="80.0" h="40.0" x="3582.5" y="7625.0"/> </glyph> <glyph class="source and sink" id="s3229_sa1838" compartmentRef="c13_ca13"> <label text="s3229"/> <bbox w="30.0" h="30.0" x="3646.5" y="7681.0"/> </glyph> <glyph class="macromolecule" id="s3230_sa1839" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p73 HUGO:TP73 HGNC:12003 ENTREZ:7161 UNIPROT:O15350 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p73*"/> <bbox w="80.0" h="40.0" x="3452.5" y="7675.0"/> <glyph class="state variable" id="_f2fa956c-e730-4fb8-a47c-efc5a3f1ad43"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="3499.0686" y="7670.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3231_sa1841" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 HUGO:LAMTOR5 HGNC:17955 ENTREZ:10542 UNIPROT:O43504 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HBXIP"/> <bbox w="80.0" h="40.0" x="7610.0" y="3620.0"/> </glyph> <glyph class="complex" id="s3232_csa243" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BIRC5:HBXIP Identifiers_end </body> </html> </notes> <label text="BIRC5:HBXIP"/> <bbox w="100.0" h="120.0" x="7520.0" y="3450.0"/> <glyph class="macromolecule" id="s3234_sa1842"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 HUGO:LAMTOR5 HGNC:17955 ENTREZ:10542 UNIPROT:O43504 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HBXIP"/> <bbox w="80.0" h="40.0" x="7530.0" y="3505.0"/> </glyph> <glyph class="macromolecule" id="s3233_sa1843"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: baculoviral IAP repeat containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="80.0" h="40.0" x="7530.0" y="3461.0"/> <glyph class="state variable" id="_ca61ccc9-81b7-4d5d-9ae4-81306ae4f978"> <state value="P" variable="T34"/> <bbox w="30.0" h="10.0" x="7571.949" y="3456.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3235_sa1844" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="80.0" h="40.0" x="7530.0" y="3690.0"/> <glyph class="state variable" id="_8112130a-b83a-4a30-8863-1b7171753138"> <state value="P" variable="T34"/> <bbox w="30.0" h="10.0" x="7571.949" y="3685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3236_sa1845" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: septin 4 HUGO:SEPT4 HGNC:9165 ENTREZ:5414 UNIPROT:O43236 Identifiers_end References_begin: exclusively isoform ARTS seems to be involved in apoptosis References_end </body> </html> </notes> <label text="SEPT4"/> <bbox w="80.0" h="40.0" x="3825.0" y="4331.0"/> </glyph> <glyph class="macromolecule" id="s3237_sa1846" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: septin 4 HUGO:SEPT4 HGNC:9165 ENTREZ:5414 UNIPROT:O43236 Identifiers_end References_begin: exclusively isoform ARTS seems to be involved in apoptosis References_end </body> </html> </notes> <label text="SEPT4"/> <bbox w="80.0" h="40.0" x="7040.0" y="3280.0"/> </glyph> <glyph class="complex" id="s3238_csa244" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MYC:p14ARF* Identifiers_end </body> </html> </notes> <label text="ARF:MYC"/> <bbox w="100.0" h="120.0" x="7035.0" y="7945.0"/> <glyph class="macromolecule" id="s3240_sa1850"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: uniprot:Q8N726 References_end </body> </html> </notes> <label text="p14ARF*"/> <bbox w="80.0" h="40.0" x="7048.0" y="7955.0"/> <glyph class="state variable" id="_9d47666c-f5a9-4d43-a5a8-b706e0ec225a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7099.5684" y="7950.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3239_sa1851"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="7046.0" y="8004.0"/> </glyph> </glyph> <glyph class="complex" id="s3241_csa245" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SEPT4:XIAP Identifiers_end </body> </html> </notes> <label text="SEPT4:XIAP"/> <bbox w="100.0" h="120.0" x="7130.0" y="3350.0"/> <glyph class="macromolecule" id="s3243_sa1852"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: septin 4 HUGO:SEPT4 HGNC:9165 ENTREZ:5414 UNIPROT:O43236 Identifiers_end References_begin: exclusively isoform ARTS seems to be involved in apoptosis References_end </body> </html> </notes> <label text="SEPT4"/> <bbox w="80.0" h="40.0" x="7140.0" y="3359.0"/> </glyph> <glyph class="macromolecule" id="s3242_sa1853"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="7138.75" y="3405.0"/> <glyph class="state variable" id="_e8437e33-7fe0-41be-9610-b4a69344bce6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7157.1816" y="3400.0"/> </glyph> <glyph class="state variable" id="_9e75c86a-aacd-487f-b6cb-94179864dc26"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7180.699" y="3400.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3244_sa1854" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: G1 to S phase transition 1 HUGO:GSPT1 HGNC:4621 ENTREZ:2935 UNIPROT:P15170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="GSPT1"/> <bbox w="80.0" h="40.0" x="7500.0" y="3200.0"/> </glyph> <glyph class="complex" id="s3246_csa246" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:XIAP:cleaved~GSPT1* Identifiers_end </body> </html> </notes> <label text="GSPT1:XIAP"/> <bbox w="100.0" h="130.0" x="7370.0" y="3000.0"/> <glyph class="macromolecule" id="s3248_sa1856"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: G1 to S phase transition 1 HUGO:GSPT1 HGNC:4621 ENTREZ:2935 UNIPROT:P15170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="cleaved~GSPT1*"/> <bbox w="80.0" h="40.0" x="7380.0" y="3007.0"/> <glyph class="unit of information" id="_21701f85-8f26-4423-8d77-f7c88e345293"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7395.0" y="3002.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3247_sa1857"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="7380.0" y="3060.0"/> <glyph class="state variable" id="_80462baa-ffd4-44da-8f44-fa131e86da59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7398.4316" y="3055.0"/> </glyph> <glyph class="state variable" id="_fd40a14f-d939-40c8-9df4-33ff2a1c17a9"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7421.949" y="3055.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3249_sa1858" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, apoptosis inhibitory protein HUGO:NAIP HGNC:7634 ENTREZ:4671 UNIPROT:Q13075 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:23940371 humans express different isoforms from a single NAIP gene that detect flagellin and T3SS components, respectively References_end </body> </html> </notes> <label text="NAIP"/> <clone/> <bbox w="80.0" h="40.0" x="7290.0" y="4610.0"/> </glyph> <glyph class="macromolecule" id="s3249_sa5481" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, apoptosis inhibitory protein HUGO:NAIP HGNC:7634 ENTREZ:4671 UNIPROT:Q13075 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:23940371 humans express different isoforms from a single NAIP gene that detect flagellin and T3SS components, respectively References_end </body> </html> </notes> <label text="NAIP"/> <clone/> <bbox w="80.0" h="40.0" x="10400.0" y="280.0"/> </glyph> <glyph class="macromolecule" id="s3250_sa1864" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: Generic entity NOTE: includes cleaved and non-cleaved form References_end </body> </html> </notes> <label text="Caspase3_cl_uncl*"/> <bbox w="80.0" h="40.0" x="7220.0" y="4440.0"/> </glyph> <glyph class="macromolecule" id="s3251_sa1865" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: Generic entity NOTE: include cleaved and non-cleaved form References_end </body> </html> </notes> <label text="Caspase7_cl_uncl*"/> <bbox w="80.0" h="40.0" x="7030.0" y="4780.0"/> </glyph> <glyph class="complex" id="s3252_csa247" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase3_cl_uncl*:NAIP Identifiers_end </body> </html> </notes> <label text="CASP3:NAIP"/> <bbox w="100.0" h="120.0" x="7400.0" y="4480.0"/> <glyph class="macromolecule" id="s3254_sa1860"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NLR family, apoptosis inhibitory protein HUGO:NAIP HGNC:7634 ENTREZ:4671 UNIPROT:Q13075 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:23940371 humans express different isoforms from a single NAIP gene that detect flagellin and T3SS components, respectively References_end </body> </html> </notes> <label text="NAIP"/> <bbox w="80.0" h="40.0" x="7410.0" y="4533.0"/> </glyph> <glyph class="macromolecule" id="s4605_sa1866"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: Generic entity NOTE: includes cleaved and non-cleaved form References_end </body> </html> </notes> <label text="Caspase3_cl_uncl*"/> <bbox w="80.0" h="40.0" x="7412.0" y="4489.0"/> </glyph> </glyph> <glyph class="complex" id="s3255_csa248" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase7_cl_uncl*:NAIP Identifiers_end </body> </html> </notes> <label text="CASP7:NAIP"/> <bbox w="98.666176" h="117.723656" x="7680.0" y="4540.0"/> <glyph class="macromolecule" id="s3257_sa1859"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NLR family, apoptosis inhibitory protein HUGO:NAIP HGNC:7634 ENTREZ:4671 UNIPROT:Q13075 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:23940371 humans express different isoforms from a single NAIP gene that detect flagellin and T3SS components, respectively References_end </body> </html> </notes> <label text="NAIP"/> <bbox w="80.0" h="40.0" x="7690.0" y="4593.0"/> </glyph> <glyph class="macromolecule" id="s3256_sa1867"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: Generic entity NOTE: include cleaved and non-cleaved form References_end </body> </html> </notes> <label text="Caspase7_cl_uncl*"/> <bbox w="80.0" h="40.0" x="7690.0" y="4549.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3258_sa1868" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acetylcholinesterase HUGO:ACHE HGNC:108 ENTREZ:43 UNIPROT:P22303 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: PMID:22514517 References_end </body> </html> </notes> <label text="ACHE"/> <bbox w="80.0" h="40.0" x="6299.75" y="5956.25"/> </glyph> <glyph class="macromolecule" id="s3259_sa1869" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: alpha-fetoprotein HUGO:AFP HGNC:317 ENTREZ:174 UNIPROT:P02771 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="AFP"/> <bbox w="80.0" h="40.0" x="6295.75" y="6012.25"/> </glyph> <glyph class="macromolecule" id="s3267_sa1879" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acidic (leucine-rich) nuclear phosphoprotein 32 family, member A HUGO:ANP32A HGNC:13233 ENTREZ:8125 UNIPROT:P39687 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:PHAPI References_end </body> </html> </notes> <label text="ANP32A"/> <bbox w="80.0" h="40.0" x="6423.5" y="5994.0"/> </glyph> <glyph class="macromolecule" id="s3268_sa1881" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CSE1 chromosome segregation 1-like (yeast) HUGO:CSE1L HGNC:2431 ENTREZ:1434 UNIPROT:P55060 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:CAS References_end </body> </html> </notes> <label text="CSE1L"/> <bbox w="80.0" h="40.0" x="6521.0" y="5999.0"/> </glyph> <glyph class="macromolecule" id="s3269_sa1882" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase3*"/> <bbox w="80.0" h="40.0" x="3821.25" y="4102.75"/> <glyph class="unit of information" id="_afdc11ca-dba5-43f6-abeb-c75dacdd5de0"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3836.25" y="4097.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3270_sa1883" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: Generic entity NOTE: includes cleaved and non-cleaved form References_end </body> </html> </notes> <label text="Caspase3_cl_uncl*"/> <bbox w="80.0" h="40.0" x="5790.0" y="5700.0"/> </glyph> <glyph class="macromolecule" id="s3271_sa1884" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) HUGO:NDUFS1 HGNC:7707 ENTREZ:4719 UNIPROT:P28331 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="cleaved~NDUFS1*"/> <bbox w="80.0" h="40.0" x="934.25" y="4335.0"/> <glyph class="unit of information" id="_a439b63c-0156-436b-8470-d6a61d50338b"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="949.25" y="4330.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3272_sa1885" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: retinoblastoma 1 HUGO:RB1 HGNC:9884 ENTREZ:5925 UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="4706.5" y="7988.0"/> </glyph> <glyph class="macromolecule" id="s3273_sa1886" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: retinoblastoma 1 HUGO:RB1 HGNC:9884 ENTREZ:5925 UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="cleaved_RB1*"/> <bbox w="80.0" h="40.0" x="4938.5" y="7988.0"/> <glyph class="unit of information" id="_43e06287-85bc-4a32-b633-842ff449892e"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4953.5" y="7983.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3274_sa1891" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA fragmentation factor, 45kDa, alpha polypeptide HUGO:DFFA HGNC:2772 ENTREZ:1676 UNIPROT:O00273 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="cleaved~DFFA*"/> <bbox w="80.0" h="40.0" x="990.0" y="6770.0"/> <glyph class="unit of information" id="_233bad7a-9921-44c8-8121-188effffb9d6"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1005.0" y="6765.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3276_sa1901" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase7*"/> <bbox w="70.0" h="25.0" x="4812.0" y="7319.5"/> </glyph> <glyph class="nucleic acid feature" id="s3277_sa1902" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase7*"/> <bbox w="90.0" h="25.0" x="4943.0" y="7058.5"/> <glyph class="unit of information" id="_ac4ddea1-114d-416c-a370-4dcd63de2162"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4978.0" y="7053.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3278_sa1903" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28462525 References_end </body> </html> </notes> <label text="Caspase8*"/> <bbox w="90.0" h="25.0" x="4927.0" y="7086.5"/> <glyph class="unit of information" id="_ac816343-fe99-49e7-9674-e9d959a8e17e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4962.0" y="7081.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3279_sa1904" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase3*"/> <bbox w="70.0" h="25.0" x="4892.0" y="7349.5"/> </glyph> <glyph class="nucleic acid feature" id="s3280_sa1905" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase3*"/> <bbox w="90.0" h="25.0" x="4995.0" y="7083.5"/> <glyph class="unit of information" id="_da061f85-d2a3-44db-8219-46c39e564302"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5030.0" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3281_sa1906" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="70.0" h="25.0" x="4893.0" y="7318.5"/> </glyph> <glyph class="nucleic acid feature" id="s3282_sa1907" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="90.0" h="25.0" x="5016.0" y="7056.5"/> <glyph class="unit of information" id="_d8ed7e85-560e-4431-bbfa-268d37e40cc3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5051.0" y="7051.5"/> </glyph> </glyph> <glyph class="complex" id="s3286_csa252" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HIP1:IFT57 Identifiers_end </body> </html> </notes> <label text="HIP1:IFT57"/> <bbox w="100.0" h="120.0" x="7337.0" y="3893.0"/> <glyph class="macromolecule" id="s3288_sa1910"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: intraflagellar transport 57 homolog (Chlamydomonas) HUGO:IFT57 HGNC:17367 ENTREZ:55081 UNIPROT:Q9NWB7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="IFT57"/> <bbox w="80.0" h="40.0" x="7347.0" y="3945.0"/> </glyph> <glyph class="macromolecule" id="s3287_sa1911"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: huntingtin interacting protein 1 HUGO:HIP1 HGNC:4913 ENTREZ:3092 UNIPROT:O00291 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HIP1"/> <bbox w="80.0" h="40.0" x="7348.0" y="3901.0"/> </glyph> </glyph> <glyph class="complex" id="s3289_csa253" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HIP1:HTT Identifiers_end </body> </html> </notes> <label text="HIP1:HTT"/> <bbox w="97.0" h="115.0" x="7732.834" y="3934.7764"/> <glyph class="macromolecule" id="s3285_sa1912"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: huntingtin HUGO:HTT HGNC:4851 ENTREZ:3064 UNIPROT:P42858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HTT"/> <bbox w="80.0" h="40.0" x="7739.834" y="3984.7764"/> </glyph> <glyph class="macromolecule" id="s3290_sa1915"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: huntingtin interacting protein 1 HUGO:HIP1 HGNC:4913 ENTREZ:3092 UNIPROT:O00291 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HIP1"/> <bbox w="80.0" h="40.0" x="7739.834" y="3944.7764"/> </glyph> </glyph> <glyph class="macromolecule" id="s3292_sa1919" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: c-abl oncogene 1, non-receptor tyrosine kinase HUGO:ABL1 HGNC:76 ENTREZ:25 UNIPROT:P00519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="cleaved~ABL1*"/> <bbox w="80.0" h="40.0" x="7040.0" y="5060.0"/> <glyph class="unit of information" id="_e2b6956c-5fba-4f02-84ca-f4b4db0dbfdd"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7055.0" y="5055.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3295_sa1925" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nucleotide-binding oligomerization domain containing 1 HUGO:NOD1 HGNC:16390 ENTREZ:10392 UNIPROT:Q9Y239 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="NOD1"/> <bbox w="80.0" h="40.0" x="6960.0" y="5500.0"/> </glyph> <glyph class="macromolecule" id="s3296_sa1926" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MYC associated factor X HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MAX"/> <bbox w="80.0" h="40.0" x="6762.5" y="7755.0"/> </glyph> <glyph class="complex" id="s3297_csa254" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAX:MYC Identifiers_end </body> </html> </notes> <label text="MAX:MYC"/> <bbox w="100.0" h="120.0" x="6892.5" y="7605.0"/> <glyph class="macromolecule" id="s3299_sa1927"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MYC associated factor X HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MAX"/> <bbox w="80.0" h="40.0" x="6902.5" y="7615.0"/> </glyph> <glyph class="macromolecule" id="s3298_sa1928"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="6902.5" y="7655.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3300_sa1929" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MAX dimerization protein 1 HUGO:MXD1 HGNC:6761 ENTREZ:4084 UNIPROT:Q05195 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MXD1"/> <bbox w="80.0" h="40.0" x="6681.0" y="7623.0"/> <glyph class="state variable" id="_70fd32a8-6b1e-4b57-a8bd-1493933cf67f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6732.5684" y="7618.0"/> </glyph> </glyph> <glyph class="complex" id="s3301_csa255" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAX:MXD1 Identifiers_end </body> </html> </notes> <label text="MAX:MXD1"/> <bbox w="100.0" h="120.0" x="6671.0" y="7473.0"/> <glyph class="macromolecule" id="s3303_sa1930"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MYC associated factor X HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MAX"/> <bbox w="80.0" h="40.0" x="6676.0" y="7481.0"/> </glyph> <glyph class="macromolecule" id="s3302_sa1931"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MAX dimerization protein 1 HUGO:MXD1 HGNC:6761 ENTREZ:4084 UNIPROT:Q05195 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MXD1"/> <bbox w="80.0" h="40.0" x="6683.0" y="7528.0"/> <glyph class="state variable" id="_a6f25100-d675-44cb-bad5-3c90263bf5ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6734.5684" y="7523.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3304_sa1933" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 2 HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490 Identifiers_end Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:cIAP1 References_end </body> </html> </notes> <label text="BIRC2"/> <bbox w="80.0" h="40.0" x="5385.2534" y="327.7478"/> </glyph> <glyph class="macromolecule" id="s3305_sa1934" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: active BCR-related HUGO:ABR HGNC:81 ENTREZ:29 UNIPROT:Q12979 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27558815 used to describe the effect of pan-caspase inhibitors such as z-VAD-fmk Generic entity NOTE:all caspases CASP3 CASP6 CASP7 CASP8 CASP9 References_end </body> </html> </notes> <label text="active~Caspases*"/> <bbox w="80.0" h="40.0" x="7530.0" y="4680.0"/> </glyph> <glyph class="macromolecule" id="s3306_sa1935" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MAX dimerization protein 1 HUGO:MXD1 HGNC:6761 ENTREZ:4084 UNIPROT:Q05195 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MXD1"/> <bbox w="80.0" h="40.0" x="6682.5" y="7705.0"/> <glyph class="state variable" id="_be2519a7-4097-46a0-87a7-93098ce58789"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6729.0684" y="7700.0"/> </glyph> </glyph> <glyph class="source and sink" id="s3307_sa1936" compartmentRef="c13_ca13"> <label text="s3307"/> <bbox w="30.0" h="30.0" x="6707.5" y="7790.0"/> </glyph> <glyph class="source and sink" id="s3309_sa1939" compartmentRef="c1_ca1"> <label text="s3309"/> <bbox w="30.0" h="30.0" x="7845.0" y="3695.0"/> </glyph> <glyph class="macromolecule" id="s3314_sa1944" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17604717 PMID:23030059 References_end </body> </html> </notes> <label text="AKT*"/> <clone/> <bbox w="80.0" h="40.0" x="8835.001" y="1983.6742"/> <glyph class="state variable" id="_12e8aa75-a07d-4fe6-8ffa-4fbfae12f59d"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="8840.442" y="1978.6742"/> </glyph> <glyph class="state variable" id="_556c404a-da56-40ca-b643-687527a97593"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="8879.56" y="1978.6742"/> </glyph> </glyph> <glyph class="macromolecule" id="s3314_sa4192" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17604717 PMID:23030059 References_end </body> </html> </notes> <label text="AKT*"/> <clone/> <bbox w="80.0" h="40.0" x="3560.0" y="480.0"/> <glyph class="state variable" id="_21247489-6605-43fe-bc5c-0fd1b876233e"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="3565.4414" y="475.0"/> </glyph> <glyph class="state variable" id="_324d6c7a-b510-4843-ab51-1acf7a15f64d"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="3604.5586" y="475.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3317_sa6" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <bbox w="80.0" h="40.0" x="3822.9485" y="3986.5688"/> <glyph class="state variable" id="_83669458-7a30-40d0-8d36-d07e986c947f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3874.517" y="3981.5688"/> </glyph> <glyph class="unit of information" id="_360d405c-cb47-487f-af84-d41bad757f2f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3837.9485" y="3981.5688"/> </glyph> </glyph> <glyph class="complex" id="s3318_csa256" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN1:Ca2+ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CAPN1"/> <bbox w="102.0" h="86.0" x="674.25" y="3945.0"/> <glyph class="macromolecule" id="s306_sa1949"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <bbox w="80.0" h="40.0" x="684.25" y="3974.0"/> </glyph> <glyph class="simple chemical" id="s7614_sa1950"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="734.75" y="3948.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3322_sa1952" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="1378.75" y="4502.0"/> <glyph class="state variable" id="_297dc468-48ee-4d24-afc4-0ae27fb22cfa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1415.188" y="4497.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3327_sa1956" compartmentRef="c4_ca4"> <label text="ROS"/> <bbox w="70.0" h="25.0" x="1463.75" y="4550.5"/> </glyph> <glyph class="complex" id="s3328_csa257" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HSP70*:cleaved~AIFM1* Identifiers_end </body> </html> </notes> <label text="AIFM1:HSP70"/> <bbox w="110.0" h="120.0" x="6525.0" y="3210.0"/> <glyph class="macromolecule" id="s3330_sa1957"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 heat shock 70kDa protein 1B HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 heat shock 70kDa protein 1-like HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="6543.0" y="3265.0"/> </glyph> <glyph class="macromolecule" id="s3329_sa1958"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <bbox w="80.0" h="40.0" x="6543.0" y="3219.0"/> <glyph class="state variable" id="_8ad26148-c8e4-440f-8715-04e81be933ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6594.5684" y="3214.0"/> </glyph> <glyph class="unit of information" id="_f3e055a6-98f3-4c79-9524-9c850f4c1e31"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6558.0" y="3214.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3331_sa1959" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <bbox w="80.0" h="40.0" x="6380.0" y="3120.0"/> <glyph class="state variable" id="_2e65ab5f-790e-4d23-9578-0be69419f6ad"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6426.5684" y="3115.0"/> </glyph> <glyph class="unit of information" id="_ecec9e98-0b87-4717-ab91-3c9b7f668c93"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6395.0" y="3115.0"/> </glyph> </glyph> <glyph class="source and sink" id="s3332_sa1960" compartmentRef="c1_ca1"> <label text="s3332"/> <bbox w="30.0" h="30.0" x="6405.0" y="3035.0"/> </glyph> <glyph class="complex" id="s3333_csa258" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DIABLO:XIAP Identifiers_end </body> </html> </notes> <label text="DIABLO:XIAP"/> <bbox w="100.0" h="130.0" x="7350.0" y="3275.0"/> <glyph class="macromolecule" id="s3335_sa1961"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: diablo, IAP-binding mitochondrial protein HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DIABLO"/> <bbox w="80.0" h="40.0" x="7358.0" y="3288.0"/> <glyph class="state variable" id="_64ac2925-1409-4bb5-bc33-057243a6b22a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7409.5684" y="3283.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3334_sa1962"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="7360.75" y="3336.0"/> <glyph class="state variable" id="_307b1e7d-6524-4f4a-b481-4441a29c3ed9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7379.1816" y="3331.0"/> </glyph> <glyph class="state variable" id="_0b78fd19-5c8c-4960-b7da-760bc622816d"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7402.699" y="3331.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3336_csa259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BIRC5:DIABLO Identifiers_end </body> </html> </notes> <label text="BIRC5:DIABLO"/> <bbox w="100.0" h="120.0" x="7380.0" y="3530.0"/> <glyph class="macromolecule" id="s3_sa1963"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: diablo, IAP-binding mitochondrial protein HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DIABLO"/> <bbox w="80.0" h="40.0" x="7390.0" y="3586.0"/> <glyph class="state variable" id="_2f105871-be81-4af2-b15f-7d1793f91a21"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7441.5684" y="3581.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4613_sa3597"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps/Modules_begin: Maps/Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="80.0" h="40.0" x="7393.237" y="3542.0703"/> <glyph class="state variable" id="_7c353545-4057-471a-97d9-23e8a93ba7a7"> <state value="P" variable="T34"/> <bbox w="30.0" h="10.0" x="7435.186" y="3537.0703"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3339_sa1965" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 7 HUGO:BIRC7 HGNC:13702 ENTREZ:79444 UNIPROT:Q96CA5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:ML-IAP References_end </body> </html> </notes> <label text="BIRC7"/> <bbox w="80.0" h="40.0" x="7170.0" y="3690.0"/> </glyph> <glyph class="complex" id="s3340_csa260" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BIRC7:DIABLO Identifiers_end </body> </html> </notes> <label text="BIRC7:DIABLO"/> <bbox w="100.0" h="120.0" x="7240.0" y="3530.0"/> <glyph class="macromolecule" id="s3342_sa1966"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: baculoviral IAP repeat containing 7 HUGO:BIRC7 HGNC:13702 ENTREZ:79444 UNIPROT:Q96CA5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:ML-IAP References_end </body> </html> </notes> <label text="BIRC7"/> <bbox w="80.0" h="40.0" x="7252.058" y="3541.7244"/> </glyph> <glyph class="macromolecule" id="s3341_sa1967"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: diablo, IAP-binding mitochondrial protein HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DIABLO"/> <bbox w="80.0" h="40.0" x="7252.0" y="3586.0"/> <glyph class="state variable" id="_70a1df22-a3f8-403e-83a5-52bdae2a24f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7303.5684" y="3581.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3343_csa261" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BIRC7:cleaved~Caspase9* Identifiers_end </body> </html> </notes> <label text="BIRC7:CASP9"/> <bbox w="105.125" h="120.0" x="7127.4375" y="5460.0"/> <glyph class="macromolecule" id="s3345_sa1968"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: baculoviral IAP repeat containing 7 HUGO:BIRC7 HGNC:13702 ENTREZ:79444 UNIPROT:Q96CA5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:ML-IAP References_end </body> </html> </notes> <label text="BIRC7"/> <bbox w="80.0" h="40.0" x="7137.4375" y="5472.125"/> </glyph> <glyph class="macromolecule" id="s3344_sa1969"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase9*"/> <bbox w="80.0" h="40.0" x="7137.4375" y="5520.125"/> <glyph class="unit of information" id="_588a7e3f-a759-4131-ad39-fffda3c5a004"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7152.4375" y="5515.125"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3346_csa262" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:XIAP:cleaved~Caspase9* Identifiers_end </body> </html> </notes> <label text="cleaved_CAPSP9:XIAP"/> <bbox w="104.25" h="127.75" x="7247.875" y="5356.125"/> <glyph class="macromolecule" id="s3348_sa1970"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="7262.125" y="5413.875"/> <glyph class="state variable" id="_afb0e419-5fb7-4f8e-bd8e-a6b239c35d2d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7280.5566" y="5408.875"/> </glyph> <glyph class="state variable" id="_46b9053c-a27a-4599-b263-745c43973e8a"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7304.074" y="5408.875"/> </glyph> </glyph> <glyph class="macromolecule" id="s3347_sa1971"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase9*"/> <bbox w="80.0" h="40.0" x="7257.875" y="5366.125"/> <glyph class="unit of information" id="_998b838c-6926-4241-8f0b-6c9bcfe3df3d"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7272.875" y="5361.125"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3349_sa1975" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 HUGO:SLC25A1 HGNC:10979 ENTREZ:6576 UNIPROT:P53007 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC25A1"/> <bbox w="80.0" h="40.0" x="544.25" y="5225.0"/> </glyph> <glyph class="macromolecule" id="s3351_sa1976" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 1 (neutral amino acid transporter), member 5 HUGO:SLC1A5 HGNC:10943 ENTREZ:6510 UNIPROT:Q15758 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SLC1A5"/> <bbox w="80.0" h="40.0" x="90.0" y="3280.0"/> </glyph> <glyph class="simple chemical" id="s3353_sa1979" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18050 KEGGCOMPOUND:C00064 CAS:56-85-9 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="L-glutamine"/> <bbox w="94.5" h="29.0" x="916.25" y="3333.5"/> </glyph> <glyph class="macromolecule" id="s3355_sa1980" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 38, member 5 HUGO:SLC38A5 HGNC:18070 ENTREZ:92745 UNIPROT:Q8WUX1 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC38A5"/> <bbox w="80.0" h="40.0" x="90.0" y="3220.0"/> </glyph> <glyph class="nucleic acid feature" id="s3358_sa1983" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 38, member 5 HUGO:SLC38A5 HGNC:18070 ENTREZ:92745 UNIPROT:Q8WUX1 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC38A5"/> <bbox w="90.0" h="25.0" x="7172.5" y="7074.5"/> <glyph class="unit of information" id="_3a471010-d535-4679-ac7b-35d4a6f9c90a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7207.5" y="7069.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3359_sa1984" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 1 (neutral amino acid transporter), member 5 HUGO:SLC1A5 HGNC:10943 ENTREZ:6510 UNIPROT:Q15758 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC1A5"/> <bbox w="90.0" h="25.0" x="7232.5" y="7104.5"/> <glyph class="unit of information" id="_c3065d86-5066-4504-a06d-f30d865f9f02"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7267.5" y="7099.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3360_sa1985" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 38, member 5 HUGO:SLC38A5 HGNC:18070 ENTREZ:92745 UNIPROT:Q8WUX1 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC38A5"/> <bbox w="70.0" h="25.0" x="7080.977" y="7338.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3361_sa1986" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 1 (neutral amino acid transporter), member 5 HUGO:SLC1A5 HGNC:10943 ENTREZ:6510 UNIPROT:Q15758 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SLC1A5"/> <bbox w="70.0" h="25.0" x="7160.977" y="7338.7983"/> </glyph> <glyph class="macromolecule" id="s3363_sa1988" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 16, member 1 (monocarboxylic acid transporter 1) HUGO:SLC16A1 HGNC:10922 ENTREZ:6566 UNIPROT:P53985 solute carrier family 16, member 3 (monocarboxylic acid transporter 4) HUGO:SLC16A3 HGNC:10924 ENTREZ:9123 UNIPROT:O15427 solute carrier family 16, member 4 (monocarboxylic acid transporter 5) HUGO:SLC16A4 HGNC:10925 ENTREZ:9122 UNIPROT:O15374 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: monocarboxylate transporters References_end </body> </html> </notes> <label text="MCT*"/> <bbox w="80.0" h="40.0" x="100.0" y="2400.0"/> </glyph> <glyph class="simple chemical" id="s3364_sa1989" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16977 KEGGCOMPOUND:C00041 CAS:56-41-7 Identifiers_end </body> </html> </notes> <label text="L-alanine"/> <bbox w="70.0" h="25.0" x="951.75" y="5898.5"/> </glyph> <glyph class="simple chemical" id="s3365_sa1991" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="L-glutamate"/> <bbox w="70.0" h="25.0" x="901.0" y="6171.5"/> </glyph> <glyph class="simple chemical" id="s3366_sa1993" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18050 KEGGCOMPOUND:C00064 CAS:56-85-9 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamine"/> <bbox w="70.0" h="25.0" x="461.0" y="6161.5"/> </glyph> <glyph class="macromolecule" id="s3367_sa1994" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: malic enzyme 3, NADP(+)-dependent, mitochondrial HUGO:ME3 HGNC:6985 ENTREZ:10873 UNIPROT:Q16798 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ME3"/> <bbox w="80.0" h="40.0" x="984.25" y="5605.0"/> </glyph> <glyph class="simple chemical" id="s3368_sa1998" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16134 KEGGCOMPOUND:C00014 CAS:7664-41-7 Identifiers_end </body> </html> </notes> <label text="NH3"/> <clone/> <bbox w="70.0" h="25.0" x="795.0" y="6137.5"/> </glyph> <glyph class="simple chemical" id="s3368_sa2018" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16134 KEGGCOMPOUND:C00014 CAS:7664-41-7 Identifiers_end </body> </html> </notes> <label text="NH3"/> <clone/> <bbox w="70.0" h="25.0" x="831.75" y="5878.5"/> </glyph> <glyph class="macromolecule" id="s3369_sa1999" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaminase HUGO:GLS HGNC:4331 ENTREZ:2744 UNIPROT:O94925 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLS"/> <bbox w="80.0" h="40.0" x="566.0" y="6094.0"/> </glyph> <glyph class="nucleic acid feature" id="s3370_sa2000" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 23a HUGO:MIR23A HGNC:31605 ENTREZ:407010 Identifiers_end </body> </html> </notes> <label text="MIR23A"/> <bbox w="70.0" h="25.0" x="7009.977" y="7339.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3372_sa2002" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 23b HUGO:MIR23B HGNC:31606 ENTREZ:407011 Identifiers_end </body> </html> </notes> <label text="MIR23B"/> <bbox w="90.0" h="25.0" x="7561.5" y="6667.5"/> <glyph class="unit of information" id="_f6f1511e-b418-41a1-a90d-80735bda4072"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7591.5" y="6662.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3373_sa2003" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 23a HUGO:MIR23A HGNC:31605 ENTREZ:407010 Identifiers_end </body> </html> </notes> <label text="MIR23A"/> <bbox w="90.0" h="25.0" x="7489.5" y="6667.5"/> <glyph class="unit of information" id="_5ad5be06-46cb-4f04-a0a0-11015756f4af"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7519.5" y="6662.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3374_sa2004" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaminase HUGO:GLS HGNC:4331 ENTREZ:2744 UNIPROT:O94925 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLS"/> <bbox w="90.0" h="25.0" x="7309.5" y="7105.5"/> <glyph class="unit of information" id="_dc21454f-fa2f-479a-b75f-b389ef31b27f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7344.5" y="7100.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3375_sa2005" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chromosome 9 open reading frame 3 HUGO:C9orf3 HGNC:1361 ENTREZ:84909 UNIPROT:Q8N6M6 Identifiers_end References_begin: synonym:aminopeptidase_O References_end </body> </html> </notes> <label text="APO*"/> <bbox w="70.0" h="25.0" x="7020.977" y="7308.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3380_sa588" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: minichromosome maintenance complex component 7 HUGO:MCM7 HGNC:6950 ENTREZ:4176 UNIPROT:P33993 Identifiers_end </body> </html> </notes> <label text="pre-mRNA~MCM7*"/> <bbox w="90.0" h="25.0" x="4466.7593" y="7086.598"/> <glyph class="unit of information" id="_5a00d582-6871-4565-99a7-6cee1b64865e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4501.7593" y="7081.598"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3381_sa2006" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chromosome 9 open reading frame 3 HUGO:C9orf3 HGNC:1361 ENTREZ:84909 UNIPROT:Q8N6M6 Identifiers_end References_begin: synonym:aminopeptidase_O References_end </body> </html> </notes> <label text="pre-mRNA~APO*"/> <bbox w="90.0" h="25.0" x="7149.5" y="7109.5"/> <glyph class="unit of information" id="_bbf4867e-a0e4-4e9d-b64e-f3aa0a94053b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7184.5" y="7104.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3382_sa2007" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chromosome 9 open reading frame 3 HUGO:C9orf3 HGNC:1361 ENTREZ:84909 UNIPROT:Q8N6M6 Identifiers_end </body> </html> </notes> <label text="APO*"/> <bbox w="90.0" h="25.0" x="7145.0" y="6757.5"/> <glyph class="unit of information" id="_91a205d3-e107-4ec7-9a5c-2bf47d45c5cb"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7180.0" y="6752.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3383_sa2008" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaminase 2 (liver, mitochondrial) HUGO:GLS2 HGNC:29570 ENTREZ:27165 UNIPROT:Q9UI32 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLS2"/> <bbox w="80.0" h="40.0" x="686.0" y="6094.0"/> </glyph> <glyph class="simple chemical" id="s3384_sa2009" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17111 KEGGCOMPOUND:C00119 CAS:7540-64-9 Identifiers_end </body> </html> </notes> <label text="PRPP"/> <bbox w="70.0" h="25.0" x="991.25" y="3280.0"/> </glyph> <glyph class="macromolecule" id="s3385_sa2012" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoribosyl pyrophosphate synthetase 1 HUGO:PRPS1 HGNC:9462 ENTREZ:5631 UNIPROT:P60891 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRPS1"/> <bbox w="80.0" h="40.0" x="502.0" y="2292.0"/> </glyph> <glyph class="macromolecule" id="s3386_sa2013" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoribosyl pyrophosphate synthetase 1-like 1 HUGO:PRPS1L1 HGNC:9463 ENTREZ:221823 UNIPROT:P21108 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRPS1L1"/> <bbox w="80.0" h="40.0" x="500.0" y="2336.0"/> </glyph> <glyph class="macromolecule" id="s3387_sa2014" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoribosyl pyrophosphate synthetase 2 HUGO:PRPS2 HGNC:9465 ENTREZ:5634 UNIPROT:P11908 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRPS2"/> <bbox w="80.0" h="40.0" x="500.0" y="2380.0"/> </glyph> <glyph class="simple chemical" id="s3388_sa2015" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37737 KEGGCOMPOUND:C03090 Identifiers_end </body> </html> </notes> <label text="ribosylamine-5P"/> <bbox w="135.0" h="22.5" x="1362.5" y="2588.75"/> </glyph> <glyph class="macromolecule" id="s3389_sa2016" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamic-pyruvate transaminase (alanine aminotransferase) HUGO:GPT HGNC:4552 ENTREZ:2875 UNIPROT:P24298 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GPT"/> <bbox w="80.0" h="40.0" x="1090.0" y="6140.0"/> </glyph> <glyph class="macromolecule" id="s3390_sa2017" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamic pyruvate transaminase (alanine aminotransferase) 2 HUGO:GPT2 HGNC:18062 ENTREZ:84706 UNIPROT:Q8TD30 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GPT2"/> <bbox w="80.0" h="40.0" x="1000.0" y="6140.0"/> </glyph> <glyph class="macromolecule" id="s3391_sa2062" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate dehydrogenase 1 HUGO:GLUD1 HGNC:4335 ENTREZ:2746 UNIPROT:P00367 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUD1"/> <bbox w="80.0" h="40.0" x="440.26303" y="5923.75"/> <glyph class="state variable" id="_72c1436c-64e7-4d48-9c7f-e92bcf74c10d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="491.83157" y="5918.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3392_sa2022" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate dehydrogenase 2 HUGO:GLUD2 HGNC:4336 ENTREZ:2747 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MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUD*"/> <bbox w="80.0" h="40.0" x="546.0" y="6024.0"/> </glyph> <glyph class="macromolecule" id="s3397_sa2036" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamic-pyruvate transaminase (alanine aminotransferase) HUGO:GPT HGNC:4552 ENTREZ:2875 UNIPROT:P24298 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GPT*"/> <bbox w="80.0" h="40.0" x="1100.0" y="6070.0"/> </glyph> <glyph class="macromolecule" id="s3401_sa2060" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-ammonia ligase HUGO:GLUL HGNC:4341 ENTREZ:2752 UNIPROT:P15104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUL"/> <clone/> <bbox w="80.0" h="40.0" x="1387.0" y="3290.0"/> <glyph class="state variable" id="_1881c0e5-b46a-4ae1-b633-98e60227e62e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1438.5686" y="3285.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3401_sa3636" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-ammonia ligase HUGO:GLUL HGNC:4341 ENTREZ:2752 UNIPROT:P15104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUL"/> <clone/> <bbox w="80.0" h="40.0" x="2318.0" y="677.0"/> <glyph class="state variable" id="_6df07a19-ec9a-41be-adba-8381e6ed8331"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2369.5686" y="672.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3404_sa2048" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamate"/> <clone/> <bbox w="92.5" h="25.0" x="1213.75" y="3337.5"/> </glyph> <glyph class="simple chemical" id="s3404_sa2609" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamate"/> <clone/> <bbox w="70.0" h="25.0" x="8701.0" y="728.0"/> </glyph> <glyph class="simple chemical" id="s3404_sa5236" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamate"/> <clone/> <bbox w="70.0" h="25.0" x="8685.0" y="312.5"/> </glyph> <glyph class="simple chemical" id="s3404_sa5357" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamate"/> <clone/> <bbox w="70.0" h="25.0" x="8327.5" y="1126.25"/> </glyph> <glyph class="simple chemical" id="s3405_sa2049" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20424262 References_end </body> </html> </notes> <label text="NH3"/> <clone/> <bbox w="70.0" h="25.0" x="1147.75" y="3409.5"/> </glyph> <glyph class="simple chemical" id="s3405_sa2195" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20424262 References_end </body> </html> </notes> <label text="NH3"/> <clone/> <bbox w="60.0" h="19.5" x="150.0" y="3970.25"/> </glyph> <glyph class="macromolecule" id="s3407_sa3226" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <clone/> <bbox w="80.0" h="40.0" x="4770.0" y="1080.0"/> <glyph class="state variable" id="_fbc02deb-db42-49d9-9dbc-40ecd90a7f33"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="4755.4927" y="1075.0"/> </glyph> <glyph class="state variable" id="_adf7a708-1d34-45d5-8c6a-3191f47d6f71"> <state value="" variable="S199"/> <bbox w="30.0" h="10.0" x="4811.949" y="1075.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3407_sa3939" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <clone/> <bbox w="80.0" h="40.0" x="7469.625" y="437.17188"/> <glyph class="state variable" id="_73784a9e-4015-4b31-8057-4ca86fdd1784"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="7455.1177" y="432.17188"/> </glyph> <glyph class="state variable" id="_4588ef07-b762-47c6-b4c2-68e54b171ceb"> <state value="" variable="S199"/> <bbox w="30.0" h="10.0" x="7511.574" y="432.17188"/> </glyph> </glyph> <glyph class="complex" id="s3410_csa266" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Mg2+:PPAT Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PPAT"/> <bbox w="120.0" h="104.0" x="1046.25" 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<head> <title/> </head> <body>Identifiers_begin: CHEBI:17552 KEGGCOMPOUND:C00035 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: 146-91-8 References_end </body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="70.0" h="25.0" x="1755.0" y="2837.5"/> </glyph> <glyph class="simple chemical" id="s3415_sa4772" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17552 KEGGCOMPOUND:C00035 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: 146-91-8 References_end </body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="70.0" h="25.0" x="10265.0" y="6407.5"/> </glyph> <glyph class="simple chemical" id="s3415_sa4774" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17552 KEGGCOMPOUND:C00035 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: 146-91-8 References_end </body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="70.0" h="25.0" x="10275.0" y="6697.5"/> </glyph> <glyph class="simple chemical" id="s3417_sa2802" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end </body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="70.0" h="25.0" x="1676.625" y="2785.0"/> </glyph> <glyph class="simple chemical" id="s3417_sa3721" compartmentRef="c1_ca1"> <notes> <html 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end </body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="70.0" h="25.0" x="10175.0" y="6697.5"/> </glyph> <glyph class="simple chemical" id="s3417_sa4773" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end </body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="70.0" h="25.0" x="10175.0" y="6407.5"/> </glyph> <glyph class="simple chemical" id="s3421_sa2813" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28862 Identifiers_end </body> </html> </notes> <label text="dGDP"/> <bbox w="70.0" h="25.0" x="2075.0" y="2538.5"/> </glyph> <glyph class="simple chemical" id="s3422_sa2816" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28862 Identifiers_end </body> </html> </notes> <label text="dGTP"/> <bbox w="70.0" h="25.0" x="2175.0" y="2787.5"/> </glyph> <glyph class="macromolecule" id="s3425_sa2086" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM 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text="RRM1"/> <bbox w="80.0" h="40.0" x="1283.75" y="2676.25"/> </glyph> <glyph class="macromolecule" id="s3428_sa2089" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribonucleotide reductase M2 HUGO:RRM2 HGNC:10452 ENTREZ:6241 UNIPROT:P31350 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="RRM2"/> <bbox w="80.0" h="40.0" x="1163.75" y="2706.25"/> </glyph> <glyph class="complex" id="s3429_csa314" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Fe2+:RRM1:RRM2* Identifiers_end </body> </html> </notes> <label text="RNR"/> <bbox w="100.0" h="120.0" x="1453.75" y="2676.25"/> <glyph class="simple chemical" id="s3432_sa2093"> <label text="Fe2+"/> <bbox w="52.5" h="32.5" x="1457.5" y="2730.0"/> </glyph> <glyph class="macromolecule" id="s3431_sa2827"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ribonucleotide reductase M1 HUGO:RRM1 HGNC:10451 ENTREZ:6240 UNIPROT:P23921 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="RRM1"/> <bbox w="80.0" h="40.0" x="1463.25" y="2688.25"/> </glyph> <glyph class="macromolecule" id="s3430_sa2828"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ribonucleotide reductase M2 B (TP53 inducible) HUGO:RRM2B HGNC:17296 ENTREZ:50484 UNIPROT:Q7LG56 ribonucleotide reductase M2 HUGO:RRM2 HGNC:10452 ENTREZ:6241 UNIPROT:P31350 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="RRM2*"/> <bbox w="80.0" h="40.0" x="1463.25" y="2730.25"/> </glyph> <glyph class="simple chemical" id="s3432_sa2829"> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="1525.25" y="2713.75"/> </glyph> </glyph> <glyph class="simple chemical" id="s3433_sa2261" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe2+"/> <clone/> <bbox w="25.0" h="25.0" x="7817.25" y="6526.75"/> </glyph> <glyph class="simple chemical" id="s3433_sa2312" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe2+"/> <clone/> <bbox w="25.0" h="25.0" x="10332.446" y="1509.731"/> </glyph> <glyph class="simple chemical" id="s3433_sa3656" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: 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x="9247.5" y="257.5"/> </glyph> <glyph class="nucleic acid feature" id="s3436_sa2095" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribonucleotide reductase M2 B (TP53 inducible) HUGO:RRM2B HGNC:17296 ENTREZ:50484 UNIPROT:Q7LG56 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="RRM2B"/> <bbox w="70.0" h="25.0" x="3676.1555" y="7299.558"/> </glyph> <glyph class="nucleic acid feature" id="s3437_sa2096" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribonucleotide reductase M2 B (TP53 inducible) HUGO:RRM2B HGNC:17296 ENTREZ:50484 UNIPROT:Q7LG56 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="RRM2B"/> <bbox w="90.0" h="25.0" x="3624.0" y="7081.5"/> <glyph class="unit of information" id="_71c6f249-41e1-4593-baaf-03fd0e9b8fb5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3659.0" y="7076.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3439_sa2097" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RNA, 5.8S ribosomal 1 HUGO:RNA5-8S1 HGNC:44282 Identifiers_end </body> </html> </notes> <label text="RNA"/> <bbox w="90.0" h="25.0" x="1265.0" y="2997.5"/> <glyph class="unit of information" id="_64e0787a-e735-4e38-8945-57110d3ffc1f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1300.0" y="2992.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3440_sa2098" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA replication helicase 2 homolog (yeast) HUGO:DNA2 HGNC:2939 ENTREZ:1763 UNIPROT:P51530 Identifiers_end </body> </html> </notes> <label text="DNA2"/> <bbox w="70.0" h="25.0" x="917.5" y="7022.5"/> </glyph> <glyph class="simple chemical" id="s3441_sa2099" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15904 KEGGCOMPOUND:C00638 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="long-chain fatty acid"/> <bbox w="145.0" h="22.5" x="746.74347" y="3066.875"/> </glyph> <glyph class="macromolecule" id="s3446_sa2268" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 1 HUGO:PRDX1 HGNC:9352 ENTREZ:5052 UNIPROT:Q06830 peroxiredoxin 2 HUGO:PRDX2 HGNC:9353 ENTREZ:7001 UNIPROT:P32119 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PRDX*"/> <bbox w="80.0" h="40.0" x="11586.0" y="1594.0"/> </glyph> <glyph class="macromolecule" id="s3447_sa2265" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 1 HUGO:PRDX1 HGNC:9352 ENTREZ:5052 UNIPROT:Q06830 peroxiredoxin 2 HUGO:PRDX2 HGNC:9353 ENTREZ:7001 UNIPROT:P32119 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PRDX*"/> <bbox w="80.0" h="40.0" x="11486.0" y="1480.0"/> <glyph class="state variable" id="_86b7ca30-c756-47d8-9bfc-a9f8346933b0"> <state value="-SOH" variable=""/> <bbox w="30.0" h="10.0" x="11511.0" y="1475.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3448_sa2266" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 1 HUGO:PRDX1 HGNC:9352 ENTREZ:5052 UNIPROT:Q06830 peroxiredoxin 2 HUGO:PRDX2 HGNC:9353 ENTREZ:7001 UNIPROT:P32119 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PRDX*"/> <bbox w="80.0" h="40.0" x="11410.0" y="1584.0"/> <glyph class="state variable" id="_63df1d37-d6ef-499d-a608-8e74632eb06f"> <state value="-S-S-" 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class="simple chemical" id="s3451_sa2818" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16174 Identifiers_end </body> </html> </notes> <label text="dADP"/> <bbox w="70.0" h="25.0" x="2175.0" y="2537.5"/> </glyph> <glyph class="simple chemical" id="s3453_sa2809" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17677 Identifiers_end </body> </html> </notes> <label text="CTP"/> <bbox w="55.0" h="22.5" x="1792.5" y="3048.75"/> </glyph> <glyph class="simple chemical" id="s3455_sa2824" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16311 KEGGCOMPOUND:C00458 CAS:2056-98-6 Identifiers_end </body> </html> </notes> <label text="dCTP"/> <bbox w="70.0" h="25.0" x="2235.0" y="3037.5"/> </glyph> <glyph class="simple chemical" id="s3456_sa2800" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 17659 References_end </body> </html> </notes> <label text="UDP"/> <clone/> <bbox w="70.0" h="25.0" x="1475.0" y="2897.5"/> </glyph> <glyph class="simple chemical" id="s3456_sa3705" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 17659 References_end </body> </html> </notes> <label text="UDP"/> <clone/> <bbox w="70.0" h="25.0" x="2517.5" y="1742.5"/> </glyph> <glyph class="simple chemical" id="s3456_sa3707" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 17659 References_end </body> </html> </notes> <label text="UDP"/> <clone/> <bbox w="70.0" h="25.0" x="2265.0" y="1837.5"/> </glyph> <glyph class="simple chemical" id="s3456_sa4282" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 17659 References_end </body> </html> </notes> <label text="UDP"/> <clone/> <bbox w="70.0" h="25.0" x="1685.0" y="2837.5"/> </glyph> <glyph class="simple chemical" id="s3458_sa2810" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15713 Identifiers_end </body> </html> </notes> <label text="UTP"/> <bbox w="70.0" h="25.0" x="1685.0" y="3047.5"/> </glyph> <glyph class="simple chemical" id="s3460_sa2815" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37036 Identifiers_end </body> </html> </notes> <label text="purine 2'-deoxyribonucleoside 5'-diphosphate"/> <bbox w="288.75" h="26.75" x="2015.625" y="2586.625"/> </glyph> <glyph class="simple chemical" id="s3461_sa2799" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37038 Identifiers_end </body> </html> </notes> <label text="purine ribonucleoside 5'-diphosphate"/> <bbox w="232.75" h="28.75" x="1633.625" y="2585.625"/> </glyph> <glyph class="simple chemical" id="s3462_sa2820" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37042 Identifiers_end </body> </html> </notes> <label text="purine 2'-deoxyribonucleoside 5'-triphosphate"/> <bbox w="292.75" h="32.75" x="2013.625" y="2713.625"/> </glyph> <glyph class="simple chemical" id="s3463_sa2798" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37045 Identifiers_end </body> </html> </notes> <label text="purine ribonucleoside 5'-triphosphate"/> <bbox w="246.75" h="32.75" x="1626.625" y="2713.625"/> </glyph> <glyph class="macromolecule" id="s3464_sa2171" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: fatty acid synthase HUGO:FASN HGNC:3594 ENTREZ:2194 UNIPROT:P49327 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="FASN"/> <bbox w="80.0" h="40.0" x="579.24347" y="2868.125"/> </glyph> <glyph class="simple chemical" id="s3466_sa411" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <bbox w="70.0" h="25.0" x="2311.75" y="5262.5"/> </glyph> <glyph class="macromolecule" id="s3468_sa2175" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6512.5" y="5715.0"/> <glyph class="state variable" id="_a50c7342-850f-4d95-83af-bb3a08ade8a7"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="6525.0" y="5710.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3469_sa2540" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="3290.0" y="4290.0"/> </glyph> <glyph class="macromolecule" id="s3472_sa2239" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate, delta-, synthase 1 HUGO:ALAS1 HGNC:396 ENTREZ:211 UNIPROT:P13196 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAS1"/> <bbox w="80.0" h="40.0" x="620.0" y="3590.0"/> </glyph> <glyph class="simple chemical" id="s3478_sa2232" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17627 KEGGCOMPOUND:C00032 CAS:14875-96-8 Identifiers_end </body> </html> </notes> <label text="ferroheme b"/> <clone/> <bbox w="82.8496" h="29.706215" x="1592.8252" y="4082.147"/> </glyph> <glyph class="simple chemical" id="s3478_sa2564" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17627 KEGGCOMPOUND:C00032 CAS:14875-96-8 Identifiers_end </body> </html> </notes> <label text="ferroheme b"/> <clone/> <bbox w="70.0" h="25.0" x="3255.0" y="4247.5"/> </glyph> <glyph class="phenotype" id="s3479_sa2260" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: GO:0006880 References_end </body> </html> </notes> <label text="Intracellular sequestering~of iron ion"/> <clone/> <bbox w="80.0" h="30.0" x="7955.75" y="6524.25"/> </glyph> <glyph class="phenotype" id="s3479_sa3657" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: GO:0006880 References_end </body> </html> </notes> <label text="Intracellular sequestering~of iron ion"/> <clone/> <bbox w="190.13513" h="33.995956" x="2754.9324" y="1193.0021"/> </glyph> <glyph class="simple chemical" id="s3480_sa2284" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18421 KEGGCOMPOUND:C00704 CAS:11062-77-4 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="O2-"/> <clone/> <bbox w="70.0" h="25.0" x="8010.25" y="6627.5"/> </glyph> <glyph class="simple chemical" id="s3480_sa3255" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18421 KEGGCOMPOUND:C00704 CAS:11062-77-4 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="O2-"/> <clone/> <bbox w="70.0" h="25.0" x="6845.5" y="1665.0"/> </glyph> <glyph class="complex" id="s3481_csa285" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cu2+:SOD1:Zn2+ Identifiers_end Maps_Modules_begin: MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SOD1"/> <bbox w="108.0" h="84.0" x="8060.0" y="6447.0"/> <glyph class="macromolecule" id="s2538_sa2287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: superoxide dismutase 1, soluble HUGO:SOD1 HGNC:11179 ENTREZ:6647 UNIPROT:P00441 Identifiers_end Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SOD1"/> <bbox w="80.0" h="40.0" x="8069.0" y="6453.165"/> </glyph> <glyph class="simple chemical" id="s3483_sa2288"> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="8063.25" y="6466.835"/> </glyph> <glyph class="simple chemical" id="s3485_sa2289"> <label text="Zn2+"/> <bbox w="25.0" h="25.0" x="8127.25" y="6468.835"/> </glyph> <glyph class="macromolecule" id="s2538_sa2290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: superoxide dismutase 1, soluble HUGO:SOD1 HGNC:11179 ENTREZ:6647 UNIPROT:P00441 Identifiers_end Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SOD1"/> <bbox w="80.0" h="40.0" x="8079.0" y="6463.165"/> </glyph> <glyph class="simple chemical" id="s3483_sa2291"> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="8073.25" y="6476.835"/> </glyph> <glyph class="simple chemical" id="s3485_sa2292"> <label text="Zn2+"/> <bbox w="25.0" h="25.0" x="8137.25" y="6478.835"/> </glyph> </glyph> <glyph class="simple chemical" id="s3490_sa2300" compartmentRef="c1_ca1"> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="8239.5" y="6423.5"/> </glyph> <glyph class="simple chemical" id="s3491_sa2210" compartmentRef="c1_ca1"> <label text="Zn2+"/> <clone/> <bbox w="25.0" h="25.0" x="297.5" y="3547.5"/> </glyph> <glyph class="simple chemical" id="s3491_sa2301" compartmentRef="c1_ca1"> <label text="Zn2+"/> <clone/> <bbox w="25.0" h="25.0" x="8255.5" y="6457.5"/> </glyph> <glyph class="simple chemical" id="s3491_sa2322" compartmentRef="c1_ca1"> <label text="Zn2+"/> <clone/> <bbox w="25.0" h="25.0" x="10377.5" y="1637.5"/> </glyph> <glyph class="macromolecule" id="s3492_sa2302" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: copper chaperone for superoxide dismutase HUGO:CCS HGNC:1613 ENTREZ:9973 UNIPROT:O14618 Identifiers_end Maps_Modules_begin: MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="CCS"/> <bbox w="80.0" h="40.0" x="8183.0" y="6545.0"/> </glyph> <glyph class="simple chemical" id="s3494_sa2304" compartmentRef="c5_ca5"> <label text="Mn2+"/> <bbox w="25.0" h="25.0" x="1999.25" y="5480.0"/> </glyph> <glyph class="macromolecule" id="s3495_sa2305" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, light polypeptide HUGO:FTL HGNC:3999 ENTREZ:2512 UNIPROT:P02792 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="FTL"/> <clone/> <bbox w="80.0" h="40.0" x="7790.0" y="6447.0"/> </glyph> <glyph class="macromolecule" id="s3495_sa3654" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, light polypeptide HUGO:FTL HGNC:3999 ENTREZ:2512 UNIPROT:P02792 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="FTL"/> <clone/> <bbox w="80.0" h="40.0" x="4040.0" y="1787.0"/> </glyph> <glyph class="nucleic acid feature" id="s3496_sa2306" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 1 HUGO:PRDX1 HGNC:9352 ENTREZ:5052 UNIPROT:Q06830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PRDX1"/> <bbox w="70.0" h="25.0" x="7241.977" y="7307.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3497_sa2307" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heme oxygenase (decycling) 1 HUGO:HMOX1 HGNC:5013 ENTREZ:3162 UNIPROT:P09601 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="HMOX1"/> <bbox w="70.0" h="25.0" x="7975.0" y="7187.5"/> </glyph> <glyph class="nucleic acid feature" id="s3498_sa2314" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heme oxygenase (decycling) 1 HUGO:HMOX1 HGNC:5013 ENTREZ:3162 UNIPROT:P09601 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="HMOX1"/> <bbox w="90.0" h="25.0" x="7965.0" y="7067.5"/> <glyph class="unit of information" id="_75edb5f8-bc4d-4f48-8e5e-e9b583cc88c0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8000.0" y="7062.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3499_sa2315" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 1 HUGO:PRDX1 HGNC:9352 ENTREZ:5052 UNIPROT:Q06830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PRDX1"/> <bbox w="90.0" h="25.0" x="7402.5" y="7080.5"/> <glyph class="unit of information" id="_6ddbd174-dec7-48c6-81ac-9f8553d80f12"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7437.5" y="7075.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3500_sa2316" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: biliverdin reductase A HUGO:BLVRA HGNC:1062 ENTREZ:644 UNIPROT:P53004 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="BLVRA"/> <bbox w="80.0" h="40.0" x="10440.0" y="1570.0"/> </glyph> <glyph class="simple chemical" id="s3501_sa2317" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16990 KEGGCOMPOUND:C00486 CAS:635-65-4 Identifiers_end </body> </html> </notes> <label text="bilirubin"/> <bbox w="70.0" h="25.0" x="10261.0" y="1709.5"/> </glyph> <glyph class="macromolecule" id="s3503_sa1475" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: programmed cell death 4 (neoplastic transformation inhibitor) HUGO:PDCD4 HGNC:8763 ENTREZ:27250 UNIPROT:Q53EL6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDCD4"/> <bbox w="80.0" h="40.0" x="9616.027" y="3461.7634"/> <glyph class="state variable" id="_86998e96-e34e-4517-89e9-f949d6ea3198"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9634.459" y="3456.7634"/> </glyph> <glyph class="state variable" id="_15a7e263-1f2d-4fcf-b3ef-9a5922619b63"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9665.096" y="3456.7634"/> </glyph> </glyph> <glyph class="macromolecule" id="s3504_sa1476" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: programmed cell death 4 (neoplastic transformation inhibitor) HUGO:PDCD4 HGNC:8763 ENTREZ:27250 UNIPROT:Q53EL6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PDCD4"/> <bbox w="80.0" h="40.0" x="9816.027" y="3463.7634"/> <glyph class="state variable" id="_36ebdf07-e6cc-4157-867a-25c14d1a3303"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9829.459" y="3458.7634"/> </glyph> <glyph class="state variable" id="_87ebb965-5ed1-4a30-bd80-6944fe9740ca"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9865.096" y="3458.7634"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3509_sa2356" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="70.0" h="25.0" x="2916.5" y="7315.0"/> </glyph> <glyph class="nucleic acid feature" id="s3510_sa2358" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="70.0" h="25.0" x="2834.5" y="7312.0"/> </glyph> <glyph class="nucleic acid feature" id="s3511_sa2359" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="90.0" h="25.0" x="2708.0" y="7039.75"/> <glyph class="unit of information" id="_5d3bbe95-171a-4aeb-bb07-a2bb90a02c79"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2743.0" y="7034.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3514_sa2362" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear respiratory factor 1 HUGO:NRF1 HGNC:7996 ENTREZ:4899 UNIPROT:Q16656 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="NRF1"/> <bbox w="90.0" h="25.0" x="2638.0" y="7039.75"/> <glyph class="unit of information" id="_f5997703-974d-495f-a20b-0f76c036568f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2673.0" y="7034.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3515_sa2363" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear respiratory factor 1 HUGO:NRF1 HGNC:7996 ENTREZ:4899 UNIPROT:Q16656 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="NRF1"/> <bbox w="70.0" h="25.0" x="2746.5" y="7352.0"/> </glyph> <glyph class="nucleic acid feature" id="s3516_sa2364" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 beta HUGO:PPARGC1B HGNC:30022 ENTREZ:133522 UNIPROT:Q86YN6 Identifiers_end </body> </html> </notes> <label text="PPARGC1B"/> <bbox w="70.0" h="25.0" x="2754.5" y="7312.0"/> </glyph> <glyph class="nucleic acid feature" id="s3517_sa2365" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 beta HUGO:PPARGC1B HGNC:30022 ENTREZ:133522 UNIPROT:Q86YN6 Identifiers_end </body> </html> </notes> <label text="PPARGC1B"/> <bbox w="90.0" h="25.0" x="2612.0" y="7074.75"/> <glyph class="unit of information" id="_0aaf437d-7c19-4cab-8990-1e1584e62489"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2647.0" y="7069.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3518_sa2366" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) HUGO:ATP5G1 HGNC:841 ENTREZ:516 UNIPROT:P05496 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5G1"/> <bbox w="70.0" h="25.0" x="2664.5" y="7357.25"/> </glyph> <glyph class="nucleic acid feature" id="s3519_sa2367" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) HUGO:ATP5G1 HGNC:841 ENTREZ:516 UNIPROT:P05496 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5G1"/> <bbox w="90.0" h="25.0" x="2562.0" y="7044.75"/> <glyph class="unit of information" id="_7010661e-4f64-4dbf-8716-330036a4eb2d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2597.0" y="7039.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3520_sa2368" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) HUGO:ATP5G1 HGNC:841 ENTREZ:516 UNIPROT:P05496 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5G1"/> <bbox w="80.0" h="40.0" x="2566.115" y="4534.9673"/> </glyph> <glyph class="macromolecule" id="s3521_sa2369" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) HUGO:ATP5G1 HGNC:841 ENTREZ:516 UNIPROT:P05496 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) HUGO:ATP5G2 HGNC:842 ENTREZ:517 UNIPROT:Q06055 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) HUGO:ATP5G3 HGNC:843 ENTREZ:518 UNIPROT:P48201 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5G*"/> <bbox w="80.0" h="40.0" x="2697.115" y="4535.9673"/> </glyph> <glyph class="nucleic acid feature" id="s3522_sa2370" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Va HUGO:COX5A HGNC:2267 ENTREZ:9377 UNIPROT:P20674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5A"/> <bbox w="70.0" h="25.0" x="2584.5" y="7322.0"/> </glyph> <glyph class="nucleic acid feature" id="s3523_sa2371" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Va HUGO:COX5A HGNC:2267 ENTREZ:9377 UNIPROT:P20674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5A"/> <bbox w="90.0" h="25.0" x="2524.0" y="7077.75"/> <glyph class="unit of information" id="_9c12a709-08d9-40f7-85a3-3d88968c8f13"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2559.0" y="7072.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3524_sa2372" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Va HUGO:COX5A HGNC:2267 ENTREZ:9377 UNIPROT:P20674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5A"/> <bbox w="80.0" h="40.0" x="2175.75" y="4805.0"/> </glyph> <glyph class="nucleic acid feature" id="s3525_sa2373" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) alpha HUGO:IDH3A HGNC:5384 ENTREZ:3419 UNIPROT:P50213 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3A"/> <bbox w="70.0" h="25.0" x="2581.5" y="7358.0"/> </glyph> <glyph class="nucleic acid feature" id="s3526_sa2374" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) alpha HUGO:IDH3A HGNC:5384 ENTREZ:3419 UNIPROT:P50213 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3A"/> <bbox w="90.0" h="25.0" x="2474.0" y="7047.75"/> <glyph class="unit of information" id="_4d06c5f3-774d-4438-9625-3b29a67b3e02"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2509.0" y="7042.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3527_sa2375" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) alpha HUGO:IDH3A HGNC:5384 ENTREZ:3419 UNIPROT:P50213 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3A"/> <bbox w="80.0" h="40.0" x="1300.0" y="6140.0"/> </glyph> <glyph class="macromolecule" id="s3528_sa2376" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) beta HUGO:IDH3B HGNC:5385 ENTREZ:3420 UNIPROT:O43837 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3B"/> <bbox w="80.0" h="40.0" x="1200.0" y="6140.0"/> </glyph> <glyph class="macromolecule" id="s3529_sa2377" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) gamma HUGO:IDH3G HGNC:5386 ENTREZ:3421 UNIPROT:P51553 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3C"/> <bbox w="80.0" h="40.0" x="1290.0" y="6070.0"/> </glyph> <glyph class="complex" id="s3530_csa292" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PPARGC1A:RPTOR:YY1 Identifiers_end </body> </html> </notes> <label text="mTORC1:PGC1A:YY1"/> <bbox w="200.0" h="168.5" x="2622.5" y="7456.5"/> <glyph class="macromolecule" id="s3533_sa2382"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="2682.5" y="7465.0"/> <glyph class="state variable" id="_9b873216-b779-4eb8-9292-9053d811f3d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2734.0686" y="7460.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3534_sa2383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="2722.5" y="7555.0"/> </glyph> <glyph class="macromolecule" id="s3531_sa2384"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="2722.5" y="7512.0"/> <glyph class="state variable" id="_c0349970-9826-447e-9554-7d73337664db"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="2764.4492" y="7507.0"/> </glyph> <glyph class="state variable" id="_011fdaf7-dea0-46d7-a41c-d7c97b655ed0"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="2731.095" y="7507.0"/> </glyph> <glyph class="state variable" id="_504c80e5-27d8-404d-a607-1024c8083f1d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2738.4314" y="7547.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3535_sa2385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="2638.5" y="7555.0"/> </glyph> <glyph class="macromolecule" id="s3532_sa2386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: YY1 transcription factor HUGO:YY1 HGNC:12856 ENTREZ:7528 UNIPROT:P25490 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="YY1"/> <bbox w="80.0" h="40.0" x="2639.5" y="7510.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3538_sa2392" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear respiratory factor 1 HUGO:NRF1 HGNC:7996 ENTREZ:4899 UNIPROT:Q16656 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="NRF1"/> <bbox w="80.0" h="40.0" x="1932.5" y="7665.0"/> <glyph class="state variable" id="_f873811d-baf5-4426-a7aa-2773c33a1b1b"> <state value="" variable="S47"/> <bbox w="25.0" h="10.0" x="1976.5686" y="7660.0"/> </glyph> </glyph> <glyph class="complex" id="s3539_csa293" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NRF1:PPARGC1A Identifiers_end </body> </html> </notes> <label text="NRF1:PGC1α"/> <bbox w="101.0" h="131.0" x="2112.0" y="7569.5"/> <glyph class="macromolecule" id="s3541_sa2393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear respiratory factor 1 HUGO:NRF1 HGNC:7996 ENTREZ:4899 UNIPROT:Q16656 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="NRF1"/> <bbox w="80.0" h="40.0" x="2122.0" y="7589.5"/> <glyph class="state variable" id="_8c28bc3c-998a-45ab-bb9e-ee2e195794d9"> <state value="" variable="S47"/> <bbox w="25.0" h="10.0" x="2166.0686" y="7584.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3543_sa2394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="2123.0" y="7637.5"/> <glyph class="state variable" id="_40715d2e-da8b-476f-a40a-5260a0d9abb7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2174.5686" y="7632.5"/> </glyph> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3544_sa2395" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor A, mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFAM"/> <bbox w="90.0" h="25.0" x="2450.0" y="7082.5"/> <glyph class="unit of information" id="_a327d76e-7f1b-424c-846a-8b5c4a6255af"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2485.0" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3546_sa2398" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor B1, mitochondrial HUGO:TFB1M HGNC:17037 ENTREZ:51106 UNIPROT:Q8WVM0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFB1M"/> <bbox w="70.0" h="25.0" x="2497.0" y="7364.5"/> </glyph> <glyph class="nucleic acid feature" id="s3547_sa2400" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor B1, mitochondrial HUGO:TFB1M HGNC:17037 ENTREZ:51106 UNIPROT:Q8WVM0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFB1M"/> <bbox w="90.0" h="25.0" x="2390.0" y="7052.5"/> <glyph class="unit of information" id="_56639768-bebf-469f-937a-1630139ddc60"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2425.0" y="7047.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3548_sa2397" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NFKB repressing factor HUGO:NKRF HGNC:19374 ENTREZ:55922 UNIPROT:O15226 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: genetic node References_end </body> </html> </notes> <label text="active~NRF*"/> <bbox w="80.0" h="40.0" x="2125.0" y="7475.0"/> </glyph> <glyph class="macromolecule" id="s3550_sa2401" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: GA binding protein transcription factor, alpha subunit 60kDa HUGO:GABPA HGNC:4071 ENTREZ:2551 UNIPROT:Q06546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:NRF2 References_end </body> </html> </notes> <label text="GABPA"/> <bbox w="80.0" h="40.0" x="1822.5" y="7565.0"/> </glyph> <glyph class="complex" id="s3551_csa294" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GABPA:PPARGC1A Identifiers_end </body> </html> </notes> <label text="GABPA:PGC1A"/> <bbox w="100.0" h="120.0" x="1912.5" y="7435.0"/> <glyph class="macromolecule" id="s3553_sa2402"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha HUGO:PPARGC1A HGNC:9237 ENTREZ:10891 UNIPROT:Q9UBK2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:PGC1alpha References_end </body> </html> </notes> <label text="PPARGC1A"/> <bbox w="80.0" h="40.0" x="1922.5" y="7489.0"/> <glyph class="state variable" id="_51529c0a-3713-496d-bc4a-0d29c9759948"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1974.0686" y="7484.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3552_sa2403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: GA binding protein transcription factor, alpha subunit 60kDa HUGO:GABPA HGNC:4071 ENTREZ:2551 UNIPROT:Q06546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:NRF2 References_end </body> </html> </notes> <label text="GABPA"/> <bbox w="80.0" h="40.0" x="1921.5" y="7441.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3554_sa2406" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor B2, mitochondrial HUGO:TFB2M HGNC:18559 ENTREZ:64216 UNIPROT:Q9H5Q4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TFB2M"/> <bbox w="90.0" h="25.0" x="2370.0" y="7089.5"/> <glyph class="unit of information" id="_9ec7558b-7ad1-41d2-8741-de201cd5f027"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2405.0" y="7084.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3555_sa2410" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) HUGO:NDUFS8 HGNC:7715 ENTREZ:4728 UNIPROT:O00217 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="NDUFS8"/> <bbox w="90.0" h="25.0" x="2312.0" y="7047.5"/> <glyph class="unit of information" id="_783369c0-d87b-4753-a72a-041df777952e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2347.0" y="7042.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3558_sa2421" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="VDAC1"/> <bbox w="90.0" h="25.0" x="2230.0" y="7052.5"/> <glyph class="unit of information" id="_3e9f3d84-bec6-4599-a827-0fb5e3d8e0ae"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2265.0" y="7047.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3559_sa2424" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: surfeit 1 HUGO:SURF1 HGNC:11474 ENTREZ:6834 UNIPROT:Q15526 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SURF1"/> <bbox w="90.0" h="25.0" x="2220.0" y="7080.5"/> <glyph class="unit of information" id="_61d45397-2ff3-452d-b919-378a5360560b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2255.0" y="7075.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3560_sa2427" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide HUGO:ATP5B HGNC:830 ENTREZ:506 UNIPROT:P06576 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5B"/> <bbox w="90.0" h="25.0" x="2160.0" y="7052.5"/> <glyph class="unit of information" id="_967785a1-52cf-418e-96eb-18cfc006d0c1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2195.0" y="7047.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3563_sa2429" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="8625.0" y="1785.0"/> </glyph> <glyph class="nucleic acid feature" id="s3564_sa2434" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIIa polypeptide 2 (liver) HUGO:COX7A2 HGNC:2288 ENTREZ:1347 UNIPROT:P14406 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7A2"/> <bbox w="90.0" h="25.0" x="2141.0" y="7084.5"/> <glyph class="unit of information" id="_c05d0720-ddc0-40e9-8506-d20e5dd60102"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2176.0" y="7079.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3565_sa2435" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Vb HUGO:COX5B HGNC:2269 ENTREZ:1329 UNIPROT:P10606 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5B"/> <bbox w="80.0" h="40.0" x="1996.75" y="4805.0"/> </glyph> <glyph class="nucleic acid feature" id="s3566_sa2436" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Vb HUGO:COX5B HGNC:2269 ENTREZ:1329 UNIPROT:P10606 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5B"/> <bbox w="70.0" h="25.0" x="2178.0" y="7358.5"/> </glyph> <glyph class="nucleic acid feature" id="s3567_sa2437" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Vb HUGO:COX5B HGNC:2269 ENTREZ:1329 UNIPROT:P10606 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5B"/> <bbox w="90.0" h="25.0" x="2090.0" y="7052.5"/> <glyph class="unit of information" id="_34d730df-21ab-4310-875a-9a2302f00f71"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2125.0" y="7047.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3568_sa2440" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIa polypeptide 1 HUGO:COX6A1 HGNC:2277 ENTREZ:1337 UNIPROT:P12074 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6A1"/> <bbox w="90.0" h="25.0" x="2064.0" y="7086.5"/> <glyph class="unit of information" id="_a21f620e-2ef1-4f99-941a-51053a034a5a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2099.0" y="7081.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3569_sa2441" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit VIa polypeptide 1 HUGO:COX6A1 HGNC:2277 ENTREZ:1337 UNIPROT:P12074 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6A1"/> <bbox w="70.0" h="25.0" x="2103.0" y="7320.5"/> </glyph> <glyph class="macromolecule" id="s3570_sa2442" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 HUGO:ATP5C1 HGNC:833 ENTREZ:509 UNIPROT:P36542 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5C1"/> <bbox w="80.0" h="40.0" x="2698.115" y="4612.4673"/> </glyph> <glyph class="nucleic acid feature" id="s3571_sa2443" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 HUGO:ATP5C1 HGNC:833 ENTREZ:509 UNIPROT:P36542 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5C1"/> <bbox w="90.0" h="25.0" x="1999.5" y="7048.5"/> <glyph class="unit of information" id="_e488f736-e065-4815-b72e-aff8bc582a49"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2034.5" y="7043.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3572_sa2444" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 HUGO:ATP5C1 HGNC:833 ENTREZ:509 UNIPROT:P36542 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5C1"/> <bbox w="70.0" h="25.0" x="2093.0" y="7361.5"/> </glyph> <glyph class="nucleic acid feature" id="s3573_sa2446" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquinol-cytochrome c reductase binding protein HUGO:UQCRB HGNC:12582 ENTREZ:7381 UNIPROT:P14927 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRB"/> <bbox w="90.0" h="25.0" x="1997.5" y="7082.5"/> <glyph class="unit of information" id="_dae7d323-c91e-42a2-a79e-da8235147009"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2032.5" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3574_sa2447" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquinol-cytochrome c reductase binding protein HUGO:UQCRB HGNC:12582 ENTREZ:7381 UNIPROT:P14927 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRB"/> <bbox w="70.0" h="25.0" x="2023.0" y="7321.5"/> </glyph> <glyph class="nucleic acid feature" id="s3575_sa2451" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit D, integral membrane protein HUGO:SDHD HGNC:10683 ENTREZ:6392 UNIPROT:O14521 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHD"/> <bbox w="90.0" h="25.0" x="1919.5" y="7038.5"/> <glyph class="unit of information" id="_57159c95-ef19-4dff-9f6b-631c20c9dde5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1954.5" y="7033.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3576_sa2452" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit D, integral membrane protein HUGO:SDHD HGNC:10683 ENTREZ:6392 UNIPROT:O14521 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHD"/> <bbox w="70.0" h="25.0" x="2015.0" y="7368.5"/> </glyph> <glyph class="nucleic acid feature" id="s3577_sa2453" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa HUGO:SDHC HGNC:10682 ENTREZ:6391 UNIPROT:Q99643 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHC"/> <bbox w="90.0" h="25.0" x="1911.5" y="7081.5"/> <glyph class="unit of information" id="_74b6a7f5-af18-4599-bc21-a0e3c415d5ca"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1946.5" y="7076.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3578_sa2454" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa HUGO:SDHC HGNC:10682 ENTREZ:6391 UNIPROT:Q99643 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHC"/> <bbox w="70.0" h="25.0" x="1943.0" y="7320.5"/> </glyph> <glyph class="nucleic acid feature" id="s3579_sa2455" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit B, iron sulfur (Ip) HUGO:SDHB HGNC:10681 ENTREZ:6390 UNIPROT:P21912 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHB"/> <bbox w="90.0" h="25.0" x="1841.5" y="7041.5"/> <glyph class="unit of information" id="_572cb07d-e49a-4d29-aa75-209027a1cb46"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1876.5" y="7036.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3580_sa2456" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: succinate dehydrogenase complex, subunit B, iron sulfur (Ip) HUGO:SDHB HGNC:10681 ENTREZ:6390 UNIPROT:P21912 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SDHB"/> <bbox w="70.0" h="25.0" x="1940.0" y="7360.5"/> </glyph> <glyph class="nucleic acid feature" id="s3581_sa2458" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="VDAC3"/> <bbox w="90.0" h="25.0" x="1829.5" y="7082.5"/> <glyph class="unit of information" id="_2505a7be-b06b-4361-8ffb-15b8e4dee315"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1864.5" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3582_sa2459" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="VDAC3"/> <bbox w="70.0" h="25.0" x="1860.0" y="7320.5"/> </glyph> <glyph class="nucleic acid feature" id="s3583_sa2461" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrial ribosomal protein S12 HUGO:MRPS12 HGNC:10380 ENTREZ:6183 UNIPROT:O15235 Identifiers_end </body> </html> </notes> <label text="MRPS12"/> <bbox w="90.0" h="25.0" x="1769.5" y="7038.5"/> <glyph class="unit of information" id="_67e93676-1632-4255-970b-b060a33cc02d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1804.5" y="7033.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3584_sa2462" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrial ribosomal protein S12 HUGO:MRPS12 HGNC:10380 ENTREZ:6183 UNIPROT:O15235 Identifiers_end </body> </html> </notes> <label text="MRPS12"/> <bbox w="70.0" h="25.0" x="1860.0" y="7362.5"/> </glyph> <glyph class="source and sink" id="s3585_sa2463" compartmentRef="c4_ca4"> <label text="s3585"/> <bbox w="30.0" h="30.0" x="1416.75" y="4785.0"/> </glyph> <glyph class="macromolecule" id="s3586_sa279" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) HUGO:NDUFS3 HGNC:7710 ENTREZ:4722 UNIPROT:O75489 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="cleaved~NDUFS3*"/> <bbox w="80.0" h="40.0" x="844.25" y="4335.0"/> <glyph class="unit of information" id="_87383966-092e-4e3e-ad3c-cf299e804cd2"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="859.25" y="4330.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3593_sa2562" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle HUGO:ATP5A1 HGNC:823 ENTREZ:498 UNIPROT:P25705 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ATP5A1"/> <bbox w="80.0" h="40.0" x="2571.9307" y="4657.975"/> </glyph> <glyph class="simple chemical" id="s3594_sa2563" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26355 KEGGCOMPOUND:C00032 CAS:14875-96-8 Identifiers_end </body> </html> </notes> <label text="heme b"/> <bbox w="70.0" h="25.0" x="1599.25" y="3924.5"/> </glyph> <glyph class="macromolecule" id="s3596_sa2565" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: polymerase (RNA) mitochondrial (DNA directed) HUGO:POLRMT HGNC:9200 ENTREZ:5442 UNIPROT:O00411 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="POLRMT"/> <bbox w="80.0" h="40.0" x="3284.25" y="5475.0"/> </glyph> <glyph class="nucleic acid feature" id="s3598_sa2567" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CyclinD1*"/> <bbox w="70.0" h="25.0" x="5923.977" y="7303.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3599_sa2568" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CyclinD1*"/> <bbox w="90.0" h="25.0" x="5983.5" y="7057.5"/> <glyph class="unit of information" id="_574f2cc6-b1ea-4b9b-9c89-eb0346b5c3ff"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6018.5" y="7052.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3601_sa2571" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FK506 binding protein 8, 38kDa HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="FKBP8"/> <bbox w="80.0" h="40.0" x="9002.5" y="2895.0"/> </glyph> <glyph class="complex" id="s3612_csa301" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FKBP8:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1:FKBP8"/> <bbox w="179.0" h="119.0" x="9165.5" y="2695.5"/> <glyph class="macromolecule" id="s3608_sa2576"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="9172.5" y="2743.5"/> </glyph> <glyph class="macromolecule" id="s3609_sa2577"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9172.5" y="2701.5"/> </glyph> <glyph class="macromolecule" id="s3610_sa2578"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="9258.5" y="2745.5"/> <glyph class="state variable" id="_0a9f4a0e-e02f-435c-a6fd-b90def3e3925"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9300.449" y="2740.5"/> </glyph> <glyph class="state variable" id="_8ca1b03b-4c11-4a14-86b4-a49917f99789"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="9267.095" y="2740.5"/> </glyph> <glyph class="state variable" id="_d0ae4670-94b0-44cc-b7fc-c55fd67e40e0"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9274.432" y="2780.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3611_sa2579"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: FK506 binding protein 8, 38kDa HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="FKBP8"/> <bbox w="80.0" h="40.0" x="9258.25" y="2701.0"/> </glyph> </glyph> <glyph class="complex" id="s3617_csa302" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FKBP8:GTP:RHEB Identifiers_end </body> </html> </notes> <label text="FKBP8:RHEB:GTP"/> <bbox w="100.0" h="145.0" x="9153.501" y="2969.174"/> <glyph class="macromolecule" id="s3616_sa2580"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: FK506 binding protein 8, 38kDa HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="FKBP8"/> <bbox w="80.0" h="40.0" x="9163.501" y="2973.5076"/> </glyph> <glyph class="simple chemical" id="s2050_sa2581"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="9168.501" y="3068.674"/> </glyph> <glyph class="macromolecule" id="s2053_sa2582"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Ras homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="9163.501" y="3025.174"/> <glyph class="state variable" id="_d7e48ccd-0a6c-454e-b424-14b1c2936e00"> <state value="Pr" variable=""/> <bbox w="20.0" h="10.0" x="9176.933" y="3020.174"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3618_sa2583" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved~BCL2*"/> <bbox w="80.0" h="40.0" x="5510.0" y="4885.0"/> <glyph class="unit of information" id="_8df52186-cf3f-428f-a4ce-9c3e9496561b"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5525.0" y="4880.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3619_sa2584" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FK506 binding protein 8, 38kDa HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="FKBP8"/> <bbox w="80.0" h="40.0" x="5380.0" y="4780.0"/> </glyph> <glyph class="macromolecule" id="s3622_sa2597" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaredoxin (thioltransferase) HUGO:GLRX HGNC:4330 ENTREZ:2745 UNIPROT:P35754 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="GLRX"/> <bbox w="80.0" h="40.0" x="10177.5" y="3477.5"/> </glyph> <glyph class="macromolecule" id="s3623_sa2598" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaredoxin (thioltransferase) HUGO:GLRX HGNC:4330 ENTREZ:2745 UNIPROT:P35754 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="cleaved~GLRX*"/> <bbox w="80.0" h="40.0" x="10353.5" y="3475.5"/> <glyph class="unit of information" id="_34301f3b-b345-4a8d-a9a6-68945e0327d2"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10368.5" y="3470.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3626_sa2602" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutathione peroxidase 1 HUGO:GPX1 HGNC:4553 ENTREZ:2876 UNIPROT:P07203 glutathione peroxidase 2 (gastrointestinal) HUGO:GPX2 HGNC:4554 ENTREZ:2877 UNIPROT:P18283 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="GPX*"/> <bbox w="80.0" h="40.0" x="9340.0" y="555.0"/> </glyph> <glyph class="nucleic acid feature" id="s3627_sa2603" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin reductase 1 HUGO:TXNRD1 HGNC:12437 ENTREZ:7296 UNIPROT:Q16881 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TXNRD1"/> <bbox w="70.0" h="25.0" x="7323.977" y="7303.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3628_sa2604" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin reductase 1 HUGO:TXNRD1 HGNC:12437 ENTREZ:7296 UNIPROT:Q16881 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TXNRD1"/> <bbox w="90.0" h="25.0" x="7482.5" y="7074.5"/> <glyph class="unit of information" id="_082fa7cc-a2be-49ea-bb3c-f55974e0f467"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7517.5" y="7069.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3629_sa2605" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin reductase 1 HUGO:TXNRD1 HGNC:12437 ENTREZ:7296 UNIPROT:Q16881 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TXNRD1"/> <bbox w="80.0" h="40.0" x="11500.0" y="1880.0"/> </glyph> <glyph class="nucleic acid feature" id="s3630_sa2606" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <bbox w="70.0" h="25.0" x="7405.977" y="7338.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3631_sa2607" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <bbox w="90.0" h="25.0" x="7548.5" y="7105.5"/> <glyph class="unit of information" id="_529ef9ea-5e56-4a70-adf1-a7ddfb8a7a47"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7583.5" y="7100.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s3633_sa2610" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17515 KEGGCOMPOUND:C00669 CAS:636-58-8 Identifiers_end </body> </html> </notes> <label text="L-γ-glutamyl-L-cysteine"/> <bbox w="159.0" h="21.5" x="8880.5" y="704.25"/> </glyph> <glyph class="complex" id="s3636_csa306" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GCLC:GCLM Identifiers_end </body> </html> </notes> <label text="GCL*"/> <bbox w="104.0" h="117.0" x="8748.0" y="516.5"/> <glyph class="macromolecule" id="s3634_sa2611"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutamate-cysteine ligase, catalytic subunit HUGO:GCLC HGNC:4311 ENTREZ:2729 UNIPROT:P48506 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="GCLC"/> <bbox w="80.0" h="40.0" x="8758.0" y="527.5"/> </glyph> <glyph class="macromolecule" id="s3635_sa2614"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutamate-cysteine ligase, modifier subunit HUGO:GCLM HGNC:4312 ENTREZ:2730 UNIPROT:P48507 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="GCLM"/> <bbox w="80.0" h="40.0" x="8758.0" y="571.5"/> </glyph> </glyph> <glyph class="complex" id="s3638_csa307" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GSS Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end References_begin: PMID:10369661 cristal structure of the human enzyme References_end </body> </html> </notes> <label text="GSS"/> <bbox w="102.0" h="92.0" x="9079.0" y="579.0"/> <glyph class="macromolecule" id="s3639_sa2616"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione synthetase HUGO:GSS HGNC:4624 ENTREZ:2937 UNIPROT:P48637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="GSS"/> <bbox w="80.0" h="40.0" x="9084.0" y="599.0"/> </glyph> <glyph class="macromolecule" id="s3639_sa2617"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione synthetase HUGO:GSS HGNC:4624 ENTREZ:2937 UNIPROT:P48637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="GSS"/> <bbox w="80.0" h="40.0" x="9094.0" y="609.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3642_sa2623" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15428 CAS:56-40-6 Identifiers_end References_begin: COMPOUND:C00037 References_end </body> </html> </notes> <label text="glycine"/> <bbox w="70.0" h="25.0" x="8953.0" y="650.0"/> </glyph> <glyph class="nucleic acid feature" id="s3643_sa2626" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-cysteine ligase, catalytic subunit HUGO:GCLC HGNC:4311 ENTREZ:2729 UNIPROT:P48506 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GCLC"/> <bbox w="70.0" h="25.0" x="7403.977" y="7303.7983"/> </glyph> <glyph class="nucleic acid feature" id="s3644_sa2627" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-cysteine ligase, catalytic subunit HUGO:GCLC HGNC:4311 ENTREZ:2729 UNIPROT:P48506 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GCLC"/> <bbox w="90.0" h="25.0" x="7562.5" y="7074.5"/> <glyph class="unit of information" id="_43bba7f7-5a49-458b-836b-eb0ec45dc96f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7597.5" y="7069.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3645_sa2628" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-cysteine ligase, catalytic subunit HUGO:GCLC HGNC:4311 ENTREZ:2729 UNIPROT:P48506 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="GCLC"/> <bbox w="80.0" h="40.0" x="8590.0" y="531.0"/> </glyph> <glyph class="macromolecule" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione reductase HUGO:GSR HGNC:4623 ENTREZ:2936 UNIPROT:P00390 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GSR"/> <bbox w="80.0" h="40.0" x="9302.5" y="883.0"/> </glyph> <glyph class="simple chemical" id="s3653_sa2646"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="9307.5" y="915.0"/> </glyph> <glyph class="macromolecule" id="s3654_sa2647"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione reductase HUGO:GSR HGNC:4623 ENTREZ:2936 UNIPROT:P00390 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GSR"/> <bbox w="80.0" h="40.0" x="9312.5" y="893.0"/> </glyph> <glyph class="simple chemical" id="s3653_sa2648"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="9317.5" y="925.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3655_sa2649" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutathione peroxidase 1 HUGO:GPX1 HGNC:4553 ENTREZ:2876 UNIPROT:P07203 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="GPX1"/> <bbox w="80.0" h="40.0" x="9380.0" y="470.0"/> </glyph> <glyph class="macromolecule" id="s3656_sa2650" compartmentRef="c1_ca1"> <notes> <html 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<body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. 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w="20.0" h="10.0" x="8278.432" y="3328.0"/> </glyph> <glyph class="state variable" id="_a8e89cfa-7d32-451c-adae-48c817003f26"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8314.068" y="3328.0"/> </glyph> </glyph> <glyph class="complex" id="s3671_csa309" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL4A:DDB1:RBX1:_beta_TRCP* Identifiers_end </body> </html> </notes> <label text="s2513"/> <bbox w="176.0" h="116.0" x="8297.678" y="3414.814"/> <glyph class="macromolecule" id="s2509_sa2673"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 4A HUGO:CUL4A HGNC:2554 ENTREZ:8451 UNIPROT:Q13619 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="CUL4A"/> <bbox w="80.0" h="40.0" x="8387.678" y="3418.814"/> </glyph> <glyph class="macromolecule" id="s3674_sa2674"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="8301.678" y="3420.814"/> </glyph> <glyph class="macromolecule" id="s2516_sa2675"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: beta-transducin repeat containing E3 ubiquitin protein ligase HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 F-box and WD repeat domain containing 11 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:beta-TrCP1 synonym:beta-TrCP2 References_end </body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="8302.678" y="3467.814"/> </glyph> <glyph class="macromolecule" id="s3672_sa2676"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: damage-specific DNA binding protein 1, 127kDa HUGO:DDB1 HGNC:2717 ENTREZ:1642 UNIPROT:Q16531 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="DDB1"/> <bbox w="80.0" h="40.0" x="8387.678" y="3464.814"/> </glyph> </glyph> <glyph class="macromolecule" id="s3673_sa3476" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: H2A histone family, member X HUGO:H2AFX HGNC:4739 ENTREZ:3014 UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:H2AX References_end </body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="672.5" y="7525.0"/> <glyph class="state variable" id="_7bbf5198-2e09-4cec-9c72-ce835af55a37"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="681.09503" y="7520.0"/> </glyph> <glyph class="state variable" id="_842d850c-66a9-4b19-aa52-bdf9725b1502"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="711.9493" y="7520.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3677_sa42" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: insulin-like growth factor binding protein 1 HUGO:IGFBP1 HGNC:5469 ENTREZ:3484 UNIPROT:P08833 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="IGFBP1"/> <bbox w="80.0" h="40.0" x="3605.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s3679_sa2677" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BID"/> <bbox w="80.0" h="40.0" x="6626.5" y="2595.0"/> <glyph class="state variable" id="_03e4eecf-5126-4d20-a5b4-a6acf2fd8b0a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6677.686" y="2590.0"/> </glyph> </glyph> <glyph class="complex" id="s3684_csa64" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAPKAP1:MLST8:MTOR:RICTOR Identifiers_end </body> </html> </notes> <label text="mTORC2"/> <bbox w="174.0" h="112.0" x="9022.0" y="1690.0"/> <glyph class="macromolecule" id="s4491_sa2679"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="9110.0" y="1695.0"/> </glyph> <glyph class="macromolecule" id="s4492_sa2680"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9028.0" y="1737.0"/> </glyph> <glyph class="macromolecule" id="s3680_sa2681"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RPTOR independent companion of MTOR, complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="9111.0" y="1737.0"/> </glyph> <glyph class="macromolecule" id="s4493_sa2682"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:SIN1 References_end </body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="9027.0" y="1695.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3685_sa2683" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:SIN1 References_end </body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="9285.0" y="1727.0"/> </glyph> <glyph class="macromolecule" id="s3686_sa2684" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RPTOR independent companion of MTOR, complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="9285.0" y="1775.0"/> </glyph> <glyph class="macromolecule" id="s3687_sa3507" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 8, E3 ubiquitin protein ligase HUGO:RNF8 HGNC:10071 ENTREZ:9025 UNIPROT:O76064 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RNF8"/> <bbox w="80.0" h="40.0" x="1317.0" y="7900.0"/> </glyph> <glyph class="macromolecule" id="s3688_sa3487" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase, Mg2+/Mn2+ dependent, 1D HUGO:PPM1D HGNC:9277 ENTREZ:8493 UNIPROT:O15297 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:Wip1 References_end </body> </html> </notes> <label text="PPM1D"/> <bbox w="80.0" h="40.0" x="552.5" y="7415.0"/> </glyph> <glyph class="nucleic acid feature" id="s3698_sa2693" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, AMP-activated, beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 protein kinase, AMP-activated, beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKA_R*"/> <bbox w="90.0" h="25.0" x="3085.0" y="7085.75"/> <glyph class="unit of information" id="_be3beb97-998b-4082-bedd-1fe8571e80d2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3120.0" y="7080.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3699_sa2692" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, AMP-activated, beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 protein kinase, AMP-activated, beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKA_R*"/> <bbox w="70.0" h="25.0" x="3178.3816" y="7332.367"/> </glyph> <glyph class="macromolecule" id="s3700_sa2694" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, AMP-activated, alpha 1 catalytic subunit HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 protein kinase, AMP-activated, alpha 2 catalytic subunit HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAA*"/> <bbox w="80.0" h="40.0" x="7849.23" y="2074.4001"/> <glyph class="state variable" id="_dd0e0fd4-7221-4d91-8a9b-c3f6fc66d398"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="7891.179" y="2069.4001"/> </glyph> </glyph> <glyph class="macromolecule" id="s3701_sa2695" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, AMP-activated, gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 protein kinase, AMP-activated, gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 protein kinase, AMP-activated, gamma 3 non-catalytic subunit HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAG*"/> <bbox w="80.0" h="40.0" x="7975.98" y="2154.4001"/> </glyph> <glyph class="phenotype" id="s3702_sa2696" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="DNA~integrity"/> <bbox w="80.0" h="30.0" x="1322.5" y="7340.0"/> </glyph> <glyph class="macromolecule" id="s3703_sa2699" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="352.5" y="7025.0"/> <glyph class="state variable" id="_20274163-7d50-45da-8a1f-8f39e104adff"> <state value="P" variable="T366"/> <bbox w="35.0" h="10.0" x="358.59503" y="7020.0"/> </glyph> <glyph class="state variable" id="_9b2e2ccb-2b35-4e14-9c08-16d069548037"> <state value="?" variable="K48"/> <bbox w="30.0" h="10.0" x="394.06854" y="7020.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3704_sa2700" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="502.5" y="7025.0"/> <glyph class="state variable" id="_73ef5294-e2b2-4560-8d18-301e3a2db5b9"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="511.09503" y="7020.0"/> </glyph> <glyph class="state variable" id="_e209959c-a9bf-4c2d-8a41-42661c953dfc"> <state value="?" variable="K48"/> <bbox w="30.0" h="10.0" x="544.06854" y="7020.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3705_sa2701" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="222.2621" y="7027.072"/> <glyph class="state variable" id="_979583b1-b976-4a40-8470-079a6fbb0f49"> <state value="active" variable=""/> <bbox w="40.0" h="10.0" x="242.2621" y="7022.072"/> </glyph> <glyph class="state variable" id="_53154f5a-031c-475d-b0a4-74baf52c1e90"> <state value="?" variable="T366"/> <bbox w="35.0" h="10.0" x="228.35713" y="7022.072"/> </glyph> <glyph class="state variable" id="_7c4781a2-33fa-4d3b-ab11-e6801dee6610"> <state value="?" variable="K48"/> <bbox w="30.0" h="10.0" x="263.83063" y="7022.072"/> </glyph> </glyph> <glyph class="complex" id="s3707_csa368" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAZ1B:SMARCA5 Identifiers_end </body> </html> </notes> <label text="WICH complex"/> <bbox w="100.0" h="120.0" x="310.5" y="7436.0"/> <glyph class="macromolecule" id="s4531_sa3488"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: bromodomain adjacent to zinc finger domain, 1B HUGO:BAZ1B HGNC:961 ENTREZ:9031 UNIPROT:Q9UIG0 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:WSTF References_end </body> </html> </notes> <label text="BAZ1B"/> <bbox w="80.0" h="40.0" x="318.6406" y="7447.142"/> </glyph> <glyph class="macromolecule" id="s4533_sa3489"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 HUGO:SMARCA5 HGNC:11101 ENTREZ:8467 UNIPROT:O60264 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:SNF2H References_end </body> </html> </notes> <label text="SMARCA5"/> <bbox w="80.0" h="40.0" x="317.6406" y="7494.142"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3709_sa2707" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: twinkle mtDNA helicase HUGO:TWNK hgnc_id:HGNC:1160 HGNC:1160 ENTREZ:56652 UNIPROT:Q96RR1 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:PYROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="MT-DNA*"/> <bbox w="70.0" h="25.0" x="3429.25" y="5732.5"/> </glyph> <glyph class="nucleic acid feature" id="s3710_sa2708" compartmentRef="c5_ca5"> <label text="heavy strand transcript*"/> <bbox w="217.5" h="36.5" x="3105.5" y="5726.75"/> <glyph class="unit of information" id="_af473323-33bd-4ebc-9899-9ddbebd2bcb9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3204.25" y="5721.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3711_sa3484" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eyes absent homolog 1 (Drosophila) HUGO:EYA1 HGNC:3519 ENTREZ:2138 UNIPROT:Q99502 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="EYA1"/> <bbox w="80.0" h="40.0" x="602.5" y="7305.0"/> </glyph> <glyph class="nucleic acid feature" id="s3712_sa2709" compartmentRef="c5_ca5"> <label text="light strand transcript*"/> <bbox w="90.0" h="25.0" x="3653.25" y="5738.5"/> <glyph class="unit of information" id="_f407413f-83d9-4d39-a359-0c91b5ff1fd0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3688.25" y="5733.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3713_sa2445" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquinol-cytochrome c reductase binding protein HUGO:UQCRB HGNC:12582 ENTREZ:7381 UNIPROT:P14927 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="UQCRB"/> <bbox w="80.0" h="40.0" x="1306.75" y="4765.0"/> </glyph> <glyph class="macromolecule" id="s3714_sa2710" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome b HUGO:MT-CYB HGNC:7427 ENTREZ:4519 UNIPROT:P00156 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CYB"/> <bbox w="80.0" h="40.0" x="1306.75" y="4815.0"/> </glyph> <glyph class="nucleic acid feature" id="s3715_sa2711" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome b HUGO:MT-CYB HGNC:7427 ENTREZ:4519 UNIPROT:P00156 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CYB"/> <bbox w="90.0" h="25.0" x="3477.0" y="6003.5"/> <glyph class="unit of information" id="_982915ec-7ecf-4a76-a8f7-141f1cf40aca"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3512.0" y="5998.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3716_sa2712" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 5 HUGO:MT-ND5 HGNC:7461 ENTREZ:4540 UNIPROT:P03915 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND5"/> <bbox w="80.0" h="40.0" x="442.75" y="4870.0"/> </glyph> <glyph class="nucleic acid feature" id="s3717_sa2713" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 5 HUGO:MT-ND5 HGNC:7461 ENTREZ:4540 UNIPROT:P03915 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND5"/> <bbox w="90.0" h="25.0" x="3467.0" y="6043.5"/> <glyph class="unit of information" id="_8e21c562-2440-4b28-957e-c2f4062ffb2b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3502.0" y="6038.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3721_sa2717" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 4 HUGO:MT-ND4 HGNC:7459 ENTREZ:4538 UNIPROT:P03905 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND4"/> <bbox w="90.0" h="25.0" x="3451.0" y="6077.5"/> <glyph class="unit of information" id="_dc385e84-aadd-496e-9d6a-993d4a649245"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3486.0" y="6072.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3722_sa2718" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 4L HUGO:MT-ND4L HGNC:7460 ENTREZ:4539 UNIPROT:P03901 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND4L"/> <bbox w="90.0" h="25.0" x="3425.0" y="6117.5"/> <glyph class="unit of information" id="_b9f1d140-fbce-404a-b800-b5b1492ccc9c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3460.0" y="6112.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3724_sa2720" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 3 HUGO:MT-ND3 HGNC:7458 ENTREZ:4537 UNIPROT:P03897 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND3"/> <bbox w="90.0" h="25.0" x="3327.0" y="6117.5"/> <glyph class="unit of information" id="_b02e9379-52bb-49f6-8eb5-fd0957154ae3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3362.0" y="6112.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3726_sa2722" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome c oxidase III HUGO:MT-CO3 HGNC:7422 ENTREZ:4514 UNIPROT:P00414 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO3"/> <bbox w="90.0" h="25.0" x="3219.0" y="6117.5"/> <glyph class="unit of information" id="_f47e3cb9-69d7-4e53-9666-9cf8dddd57ba"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3254.0" y="6112.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3727_sa2723" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded ATP synthase 6 HUGO:MT-ATP6 HGNC:7414 ENTREZ:4508 UNIPROT:P00846 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ATP6"/> <bbox w="90.0" h="25.0" x="3367.0" y="6003.5"/> <glyph class="unit of information" id="_eda5cb02-b2d1-4c71-8af6-469eacdef5be"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3402.0" y="5998.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3728_sa2724" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded ATP synthase 8 HUGO:MT-ATP8 HGNC:7415 ENTREZ:4509 UNIPROT:P03928 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ATP8"/> <bbox w="90.0" h="25.0" x="3113.0" y="6117.5"/> <glyph class="unit of information" id="_c901bd45-2b50-4984-a813-18f62029f7df"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3148.0" y="6112.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3733_sa2730" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 2 HUGO:MT-ND2 HGNC:7456 ENTREZ:4536 UNIPROT:P03891 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND2"/> <bbox w="90.0" h="25.0" x="2821.0" y="6117.5"/> <glyph class="unit of information" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BRCA1/BRCA2-containing complex, subunit 3 HUGO:BRCC3 HGNC:24185 ENTREZ:79184 UNIPROT:P46736 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:BRCC36 References_end </body> </html> </notes> <label text="BRCC3"/> <clone/> <bbox w="80.0" h="40.0" x="1312.5" y="7515.0"/> </glyph> <glyph class="macromolecule" id="s3740_sa3516" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BRCA1/BRCA2-containing complex, subunit 3 HUGO:BRCC3 HGNC:24185 ENTREZ:79184 UNIPROT:P46736 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:BRCC36 References_end </body> </html> </notes> <label text="BRCC3"/> <clone/> <bbox w="80.0" h="40.0" x="932.5" y="7542.0"/> </glyph> <glyph class="nucleic acid feature" id="s3741_sa2737" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded 12S RNA HUGO:MT-RNR1 HGNC:7470 ENTREZ:4549 Identifiers_end </body> </html> </notes> <label text="MT-RNR1"/> <bbox w="90.0" h="25.0" x="2870.0" y="6033.5"/> <glyph class="unit of information" id="_0976d4ea-f749-4d02-9e92-7acb95233fda"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2905.0" y="6028.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3742_sa3499" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: histone cluster 2, H2ac HUGO:HIST2H2AC HGNC:4738 ENTREZ:8338 UNIPROT:Q16777 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="H2A*"/> <bbox w="80.0" h="40.0" x="1280.0" y="7710.0"/> <glyph class="state variable" id="_61557362-fb90-4fb5-b841-58417e4744f4"> <state value="K63ubi" variable=""/> <bbox w="40.0" h="10.0" x="1300.0" y="7705.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3744_sa3508" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 168, E3 ubiquitin protein ligase HUGO:RNF168 HGNC:26661 ENTREZ:165918 UNIPROT:Q8IYW5 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RNF168"/> <bbox w="80.0" h="40.0" x="1550.0" y="7770.0"/> </glyph> <glyph class="macromolecule" id="s3745_sa3497" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin specific peptidase 3 HUGO:USP3 HGNC:12626 ENTREZ:9960 UNIPROT:Q9Y6I4 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="USP3"/> <bbox w="80.0" h="40.0" x="1542.5" y="7475.0"/> </glyph> <glyph class="nucleic acid feature" id="s3749_sa2745" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 6 HUGO:MT-ND6 HGNC:7462 ENTREZ:4541 UNIPROT:P03923 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND6"/> <bbox w="90.0" h="25.0" x="3813.25" y="5638.5"/> <glyph class="unit of information" id="_bb457dc2-8271-436d-867f-755136fee136"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3848.25" y="5633.5"/> </glyph> </glyph> <glyph class="complex" id="s3751_csa369" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BARD1:BRCA1:BRCC3:FAM175A:UIMC1 Identifiers_end </body> </html> </notes> <label text="BRCA1-A"/> <bbox w="101.0" h="243.0" x="1106.5" y="7403.0"/> <glyph class="macromolecule" id="s4549_sa3518"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: family with sequence similarity 175, member A HUGO:FAM175A HGNC:25829 ENTREZ:84142 UNIPROT:Q6UWZ7 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:Abraxas synonym:ABRA1 synonym:CCDC98 References_end </body> </html> </notes> <label text="FAM175A"/> <bbox w="80.0" h="40.0" x="1116.9397" y="7452.943"/> </glyph> <glyph class="macromolecule" id="s4551_sa3519"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="1117.0803" y="7408.839"/> </glyph> <glyph class="macromolecule" id="s4553_sa3520"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquitin interaction motif containing 1 HUGO:UIMC1 HGNC:30298 ENTREZ:51720 UNIPROT:Q96RL1 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:RAP80 References_end </body> </html> </notes> <label text="UIMC1"/> <bbox w="80.0" h="40.0" x="1115.9397" y="7496.943"/> </glyph> <glyph class="macromolecule" id="s4555_sa3521"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BRCA1/BRCA2-containing complex, subunit 3 HUGO:BRCC3 HGNC:24185 ENTREZ:79184 UNIPROT:P46736 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:BRCC36 References_end </body> </html> </notes> <label text="BRCC3"/> <bbox w="80.0" h="40.0" x="1116.9397" y="7539.943"/> </glyph> <glyph class="macromolecule" id="s4557_sa3522"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BRCA1 associated RING domain 1 HUGO:BARD1 HGNC:952 ENTREZ:580 UNIPROT:Q99728 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BARD1"/> <bbox w="80.0" h="40.0" x="1116.9397" y="7582.943"/> </glyph> </glyph> <glyph class="macromolecule" id="s3752_sa2714" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BRCA1 associated RING domain 1 HUGO:BARD1 HGNC:952 ENTREZ:580 UNIPROT:Q99728 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BARD1"/> <bbox w="90.0" h="25.0" x="3357.0" y="6043.5"/> </glyph> <glyph class="macromolecule" id="s3753_sa2715" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="90.0" h="25.0" x="3267.0" y="6003.5"/> </glyph> <glyph class="macromolecule" id="s3754_sa2716" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="90.0" h="25.0" x="3247.0" y="6043.3364"/> <glyph class="state variable" id="_4036c6ec-42e3-447e-ab98-473c213131f1"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="3250.087" y="6038.3364"/> </glyph> <glyph class="state variable" id="_cf37c83b-b947-41d3-a505-276a514ccb26"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="3300.72" y="6038.3364"/> </glyph> <glyph class="state variable" id="_a9eb0ed8-8d32-4dc3-bb5b-bfbbd36e1b55"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="3300.9863" y="6063.3364"/> </glyph> </glyph> <glyph class="macromolecule" id="s3755_sa2719" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BRCA1"/> <bbox w="90.0" h="25.0" x="3351.0" y="6077.5"/> </glyph> <glyph class="macromolecule" id="s3756_sa2721" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 5 HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:survivin References_end </body> </html> </notes> <label text="BIRC5"/> <bbox w="90.0" h="25.0" x="3241.0" y="6081.51"/> <glyph class="state variable" id="_f163ee19-b1c7-4e0b-a970-6017a8bf7f98"> <state value="" variable="T34"/> <bbox w="25.0" h="10.0" x="3292.5679" y="6076.51"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3757_sa2725" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA lysine HUGO:MT-TK HGNC:7489 ENTREZ:4566 Identifiers_end </body> </html> </notes> <label text="MT-TK"/> <bbox w="90.0" h="25.0" x="3041.0" y="6077.5"/> <glyph class="unit of information" id="_18f016f4-5c28-4f37-b5e5-ab3f4bc6d42c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3076.0" y="6072.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3758_sa2727" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA aspartic acid HUGO:MT-TD HGNC:7478 ENTREZ:4555 Identifiers_end </body> </html> </notes> <label text="MT-TD"/> <bbox w="90.0" h="25.0" x="2941.0" y="6077.5"/> <glyph class="unit of information" id="_3aa227fd-6866-4c39-87c8-b9878a858a8f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2976.0" y="6072.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3759_sa2729" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA tryptophan HUGO:MT-TW HGNC:7501 ENTREZ:4578 Identifiers_end </body> </html> </notes> <label text="MT-TW"/> <bbox w="90.0" h="25.0" x="2841.0" y="6077.5"/> <glyph class="unit of information" id="_53d7faad-cafc-4d62-ba52-d91975210910"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2876.0" y="6072.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3760_sa2731" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA methionine HUGO:MT-TM HGNC:7492 ENTREZ:4569 Identifiers_end </body> </html> </notes> <label text="MT-TM"/> <bbox w="90.0" h="25.0" x="3180.0" y="5993.5"/> <glyph class="unit of information" id="_97d9d157-d60a-4dc3-b463-ef1be7998fc5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3215.0" y="5988.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3761_sa2732" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA isoleucine HUGO:MT-TI HGNC:7488 ENTREZ:4565 Identifiers_end </body> </html> </notes> <label text="MT-TI"/> <bbox w="90.0" h="25.0" x="3160.0" y="6033.5"/> <glyph class="unit of information" id="_05dda49f-970b-4b49-9ec9-559761fdc078"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3195.0" y="6028.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3762_sa2734" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA leucine 1 (UUA/G) HUGO:MT-TL1 HGNC:7490 ENTREZ:4567 Identifiers_end </body> </html> </notes> <label text="MT-TL1"/> <bbox w="90.0" h="25.0" x="3070.0" y="6033.5"/> <glyph class="unit of information" id="_c5f4108f-b1ca-49d8-a0c5-7f7ac5df5a7c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3105.0" y="6028.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3763_sa2736" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA valine HUGO:MT-TV HGNC:7500 ENTREZ:4577 Identifiers_end </body> </html> </notes> <label text="MT-TV"/> <bbox w="90.0" h="25.0" x="2970.0" y="6033.5"/> <glyph class="unit of information" id="_51f8be6b-b93f-4eb6-817d-9d46ef218f66"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3005.0" y="6028.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3764_sa2738" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA phenylalanine HUGO:MT-TF HGNC:7481 ENTREZ:4558 Identifiers_end </body> </html> </notes> <label text="MT-TF"/> <bbox w="90.0" h="25.0" x="2860.0" y="5993.5"/> <glyph class="unit of information" id="_8bb4d66c-3aa5-46a1-af69-52f040d828d2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2895.0" y="5988.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3765_sa2739" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA glutamine HUGO:MT-TQ HGNC:7495 ENTREZ:4572 Identifiers_end </body> </html> </notes> <label text="MT-TQ"/> <bbox w="90.0" h="25.0" x="3789.25" y="5738.5"/> <glyph class="unit of information" id="_dddff9bf-5043-4232-985e-fc1348fcedac"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3824.25" y="5733.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3766_sa2740" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA alanine HUGO:MT-TA HGNC:7475 ENTREZ:4553 Identifiers_end </body> </html> </notes> <label text="MT-TA"/> <bbox w="90.0" h="25.0" x="3789.25" y="5770.5"/> <glyph class="unit of information" id="_873b040e-2546-475b-abb7-c0538eb74f97"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3824.25" y="5765.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3767_sa2741" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA asparagine HUGO:MT-TN HGNC:7493 ENTREZ:4570 Identifiers_end </body> </html> </notes> <label text="MT-TN"/> <bbox w="90.0" h="25.0" x="3789.25" y="5806.5"/> <glyph class="unit of information" id="_5178aff9-4666-4a15-a9a6-4b56f570a23a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3824.25" y="5801.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3768_sa2742" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA cysteine HUGO:MT-TC HGNC:7477 ENTREZ:4511 Identifiers_end </body> </html> </notes> <label text="MT-TC"/> <bbox w="90.0" h="25.0" x="3789.25" y="5838.5"/> <glyph class="unit of information" id="_41012714-3fd4-463c-9e13-0a2620f40039"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3824.25" y="5833.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3769_sa2743" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA tyrosine HUGO:MT-TY HGNC:7502 ENTREZ:4579 Identifiers_end </body> </html> </notes> <label text="MT-TY"/> <bbox w="90.0" h="25.0" x="3789.25" y="5870.5"/> <glyph class="unit of information" id="_eca171aa-3836-48cf-be44-800353c30bd8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3824.25" y="5865.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3770_sa2744" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA serine 1 (UCN) HUGO:MT-TS1 HGNC:7497 ENTREZ:4574 Identifiers_end </body> </html> </notes> <label text="MT-TS1"/> <bbox w="90.0" h="25.0" x="3789.25" y="5902.5"/> <glyph class="unit of information" id="_085ab4fe-3262-42e9-bb50-4932c92965c3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3824.25" y="5897.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3771_sa2746" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA glutamic acid HUGO:MT-TE HGNC:7479 ENTREZ:4556 Identifiers_end </body> </html> </notes> <label text="MT-TE"/> <bbox w="90.0" h="25.0" x="3803.25" y="5678.5"/> <glyph class="unit of information" id="_beec4e15-e5cf-471c-9d84-b3fbe0428522"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3838.25" y="5673.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3772_sa2747" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA proline HUGO:MT-TP HGNC:7494 ENTREZ:4571 Identifiers_end </body> </html> </notes> <label text="MT-TP"/> <bbox w="90.0" h="25.0" x="3803.25" y="5708.5"/> <glyph class="unit of information" id="_8d91338e-f2db-47df-8172-2b56c3b8a9a6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3838.25" y="5703.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3773_sa2748" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 4 HUGO:MT-ND4 HGNC:7459 ENTREZ:4538 UNIPROT:P03905 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND4"/> <bbox w="80.0" h="40.0" x="442.75" y="4917.275"/> </glyph> <glyph class="macromolecule" id="s3774_sa2749" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 4L HUGO:MT-ND4L HGNC:7460 ENTREZ:4539 UNIPROT:P03901 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND4L"/> <bbox w="80.0" h="40.0" x="442.75" y="4962.0"/> </glyph> <glyph class="macromolecule" id="s3775_sa2750" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 3 HUGO:MT-ND3 HGNC:7458 ENTREZ:4537 UNIPROT:P03897 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND3"/> <bbox w="80.0" h="40.0" x="442.75" y="5005.275"/> </glyph> <glyph class="macromolecule" id="s3776_sa2751" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome c oxidase III HUGO:MT-CO3 HGNC:7422 ENTREZ:4514 UNIPROT:P00414 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO3"/> <bbox w="80.0" h="40.0" x="2266.75" y="4805.0"/> </glyph> <glyph class="macromolecule" id="s3778_sa2753" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 2 HUGO:MT-ND2 HGNC:7456 ENTREZ:4536 UNIPROT:P03891 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND2"/> <bbox w="80.0" h="40.0" x="442.75" y="5050.275"/> </glyph> <glyph class="macromolecule" id="s3779_sa2754" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded ATP synthase 6 HUGO:MT-ATP6 HGNC:7414 ENTREZ:4508 UNIPROT:P00846 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ATP6"/> <bbox w="80.0" h="40.0" x="2686.615" y="4689.4673"/> </glyph> <glyph class="macromolecule" id="s3780_sa2755" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded ATP synthase 8 HUGO:MT-ATP8 HGNC:7415 ENTREZ:4509 UNIPROT:P03928 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ATP8"/> <bbox w="80.0" h="40.0" x="2569.615" y="4699.4673"/> </glyph> <glyph class="macromolecule" id="s3781_sa2756" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 1 HUGO:MT-ND1 HGNC:7455 ENTREZ:4535 UNIPROT:P03886 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND1"/> <bbox w="80.0" h="40.0" x="442.75" y="5095.275"/> </glyph> <glyph class="macromolecule" id="s3782_sa2757" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:11998 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded NADH dehydrogenase 6 HUGO:MT-ND6 HGNC:7462 ENTREZ:4541 UNIPROT:P03923 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-ND6"/> <bbox w="80.0" h="40.0" x="440.75" y="5139.275"/> </glyph> <glyph class="nucleic acid feature" id="s3783_sa2758" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded tRNA threonine HUGO:MT-TT HGNC:7499 ENTREZ:4576 Identifiers_end </body> </html> </notes> <label text="MT-TT"/> <bbox w="90.0" h="25.0" x="3131.0" y="6077.5"/> <glyph class="unit of information" id="_e3788cb0-810b-4be6-9306-aaf773a96f02"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3166.0" y="6072.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3784_sa2759" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MTERF domain containing 3 HUGO:MTERFD3 HGNC:30779 ENTREZ:80298 UNIPROT:Q49AM1 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="MTERFD3"/> <bbox w="80.0" h="40.0" x="3434.25" y="5645.0"/> </glyph> <glyph class="macromolecule" id="s3785_sa2760" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acetyl-CoA carboxylase alpha HUGO:ACACA HGNC:84 ENTREZ:31 UNIPROT:Q13085 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:25979092 References_end </body> </html> </notes> <label text="ACACA"/> <bbox w="80.0" h="40.0" x="419.24347" y="3020.125"/> <glyph class="state variable" id="_f414ad8e-50c3-4e90-a1fe-a12e85a84179"> <state value="" variable="S1263"/> <bbox w="35.0" h="10.0" x="425.3385" y="3015.125"/> </glyph> <glyph class="state variable" id="_1daa623e-74e3-432c-a321-84f86e261f6c"> <state value="" variable="S79"/> <bbox w="25.0" h="10.0" x="463.69275" y="3015.125"/> </glyph> </glyph> <glyph class="macromolecule" id="s3786_sa2761" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acetyl-CoA carboxylase beta HUGO:ACACB HGNC:85 ENTREZ:32 UNIPROT:O00763 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:25979092 References_end </body> </html> </notes> <label text="ACACB"/> <bbox w="80.0" h="40.0" x="419.24347" y="2958.125"/> </glyph> <glyph class="complex" id="s3789_csa312" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ACAC*:Mg2+:biotin Identifiers_end </body> </html> </notes> <label text="ACC"/> <bbox w="100.0" h="120.0" x="569.74347" y="2952.125"/> <glyph class="macromolecule" id="s3787_sa2762"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: acetyl-CoA carboxylase alpha HUGO:ACACA HGNC:84 ENTREZ:31 UNIPROT:Q13085 acetyl-CoA carboxylase beta HUGO:ACACB HGNC:85 ENTREZ:32 UNIPROT:O00763 Identifiers_end Maps_Modules_begin: MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end References_begin: PMID:25979092 References_end </body> </html> </notes> <label text="ACAC*"/> <bbox w="80.0" h="40.0" x="579.74347" y="2958.125"/> </glyph> <glyph class="simple chemical" id="s3788_sa2763"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:15956 KEGGCOMPOUND: C00120 CAS: 58-85-5 </body> </html> </notes> <label text="biotin"/> <bbox w="70.0" h="25.0" x="584.74347" y="3003.625"/> </glyph> <glyph class="simple chemical" id="s3790_sa2764"> <label text="Mg2+"/> <bbox w="51.0" h="38.5" x="623.74347" y="3018.875"/> </glyph> </glyph> <glyph class="simple chemical" id="s3791_sa2767" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17544 KEGGCOMPOUND:C00288 CAS:71-52-3 Identifiers_end </body> </html> </notes> <label text="HCO3-"/> <bbox w="70.0" h="25.0" x="860.74347" y="2869.625"/> </glyph> <glyph class="macromolecule" id="s3792_sa2768" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acetyl-CoA carboxylase alpha HUGO:ACACA HGNC:84 ENTREZ:31 UNIPROT:Q13085 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:25979092 References_end </body> </html> </notes> <label text="ACACA"/> <bbox w="80.0" h="40.0" x="419.24347" y="3118.125"/> <glyph class="state variable" id="_bcf414e4-fe70-4f65-9607-b72a567c9d57"> <state value="" variable="S1263"/> <bbox w="35.0" h="10.0" x="425.3385" y="3113.125"/> </glyph> <glyph class="state variable" id="_ac6c844e-7603-458e-945d-6416fd9faa86"> <state value="P" variable="S79"/> <bbox w="30.0" h="10.0" x="461.19275" y="3113.125"/> </glyph> </glyph> <glyph class="macromolecule" id="s3793_sa2769" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="179.24348" y="2898.125"/> </glyph> <glyph class="complex" id="s3794_csa313" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ACACA:BRCA1 Identifiers_end </body> </html> </notes> <label text="ACACA:BRCA1"/> <bbox w="100.0" h="120.0" x="303.24347" y="2884.125"/> <glyph class="macromolecule" id="s3796_sa2770"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="314.24347" y="2940.125"/> </glyph> <glyph class="macromolecule" id="s3795_sa2771"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: acetyl-CoA carboxylase alpha HUGO:ACACA HGNC:84 ENTREZ:31 UNIPROT:Q13085 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:25979092 References_end </body> </html> </notes> <label text="ACACA"/> <bbox w="80.0" h="40.0" x="314.24347" y="2896.125"/> <glyph class="state variable" id="_19697184-7860-4523-b616-22f88103aa24"> <state value="" variable="S1263"/> <bbox w="35.0" h="10.0" x="320.3385" y="2891.125"/> </glyph> <glyph class="state variable" id="_02a385f4-d2bc-44d0-8eae-d488ca401e56"> <state value="P" variable="S79"/> <bbox w="30.0" h="10.0" x="356.19275" y="2891.125"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3797_sa2772" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acetyl-CoA carboxylase alpha HUGO:ACACA HGNC:84 ENTREZ:31 UNIPROT:Q13085 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:25979092 References_end </body> </html> </notes> <label text="ACACA"/> <bbox w="80.0" h="40.0" x="189.24348" y="3018.125"/> <glyph class="state variable" id="_26ad4c42-810d-4574-84c3-b7717b087fe7"> <state value="P" variable="S1263"/> <bbox w="40.0" h="10.0" x="192.83852" y="3013.125"/> </glyph> <glyph class="state variable" id="_f03e3a03-27bb-49d6-ae0b-51b42a5f39ef"> <state value="" variable="S79"/> <bbox w="25.0" h="10.0" x="233.69278" y="3013.125"/> </glyph> </glyph> <glyph class="simple chemical" id="s3798_sa2773" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30089 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="acetate"/> <bbox w="70.0" h="25.0" x="1535.0" y="5947.5"/> </glyph> <glyph class="macromolecule" id="s3799_sa2774" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acyl-CoA synthetase short-chain family member 1 HUGO:ACSS1 HGNC:16091 ENTREZ:84532 UNIPROT:Q9NUB1 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACSS1"/> <bbox w="80.0" h="40.0" x="1538.5131" y="6001.75"/> <glyph class="state variable" id="_01c87f48-ba9a-41f4-aea7-8fcc234616f9"> <state value="" variable="K642"/> <bbox w="30.0" h="10.0" x="1580.4624" y="5996.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3800_sa2775" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acyl-CoA synthetase short-chain family member 1 HUGO:ACSS1 HGNC:16091 ENTREZ:84532 UNIPROT:Q9NUB1 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACSS1"/> <bbox w="80.0" h="40.0" x="1683.5131" y="6001.75"/> <glyph class="state variable" id="_98c5216b-11ec-4f08-a6f2-a5b1bab654ff"> <state value="Ac" variable="K642"/> <bbox w="40.0" h="10.0" x="1720.4624" y="5996.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s3801_sa2779" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sirtuin 3 HUGO:SIRT3 HGNC:14931 ENTREZ:23410 UNIPROT:Q9NTG7 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SIRT3"/> <bbox w="80.0" h="40.0" x="1610.5131" y="6093.75"/> </glyph> <glyph class="simple chemical" id="s3803_sa2781" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="AMP"/> <bbox w="70.0" h="25.0" x="1464.75" y="5853.5"/> </glyph> <glyph class="simple chemical" id="s3804_sa2783" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30089 Identifiers_end </body> </html> </notes> <label text="acetate"/> <bbox w="70.0" h="25.0" x="1185.0" y="2847.5"/> </glyph> <glyph class="macromolecule" id="s3805_sa2788" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acyl-CoA synthetase short-chain family member 2 HUGO:ACSS2 HGNC:15814 ENTREZ:55902 UNIPROT:Q9NR19 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="ACSS2"/> <bbox w="80.0" h="40.0" x="982.0" y="2952.0"/> <glyph class="state variable" id="_2078e04c-0fce-4e25-ba47-e322321760db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1033.5686" y="2947.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3806_sa2789" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: acyl-CoA synthetase short-chain family member 2 HUGO:ACSS2 HGNC:15814 ENTREZ:55902 UNIPROT:Q9NR19 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="ACSS2"/> <bbox w="80.0" h="40.0" x="1117.0" y="2952.0"/> <glyph class="state variable" id="_50e8d662-aec9-4110-8f7b-929fd134f01b"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="1163.5686" y="2947.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3807_sa2807" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37044 Identifiers_end </body> </html> </notes> <label text="pyrimidine ribonucleoside 5'-triphosphate"/> <bbox w="268.75" h="32.75" x="1625.625" y="2973.625"/> </glyph> <glyph class="simple chemical" id="s3808_sa2819" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37043 Identifiers_end </body> </html> </notes> <label text="pyrimidine 2'-deoxyribonucleoside 5'-triphosphate"/> <bbox w="310.0" h="34.75" x="2065.0" y="2972.625"/> </glyph> <glyph class="simple chemical" id="s3809_sa2817" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18077 KEGGCOMPOUND:C00459 CAS:365-08-2 Identifiers_end </body> </html> </notes> <label text="dTTP"/> <bbox w="70.0" h="25.0" x="2135.0" y="3037.5"/> </glyph> <glyph class="simple chemical" id="s3810_sa2803" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37039 Identifiers_end </body> </html> </notes> <label text="pyrimidine ribonucleoside 5'-diphosphate"/> <bbox w="263.0" h="32.5" x="1628.5" y="2893.75"/> </glyph> <glyph class="phenotype" id="s3813_sa2834" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: GO:0002418 References_end </body> </html> </notes> <label text="Immune response~to tumor cell"/> <bbox w="170.0" h="45.0" x="2165.0" y="3577.5"/> </glyph> <glyph class="simple chemical" id="s3816_sa3093" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16284 Identifiers_end </body> </html> </notes> <label text="(d)ATP"/> <bbox w="70.0" h="25.0" x="6536.0625" y="5815.875"/> </glyph> <glyph class="macromolecule" id="s3825_sa2847" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class A member 2 HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HSP90AA2"/> <bbox w="80.0" h="40.0" x="7649.75" y="5354.75"/> </glyph> <glyph class="complex" id="s3827_csa317" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cu2+:MT-CO2 Identifiers_end </body> </html> </notes> <label text="holo MT-CO2"/> <bbox w="94.0" h="98.0" x="2265.75" y="5069.0"/> <glyph class="simple chemical" id="s3826_sa2848"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29036 CAS:15158-11-9 </body> </html> </notes> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="2299.75" y="5120.0"/> </glyph> <glyph class="macromolecule" id="s4032_sa2849"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase II HUGO:MT-CO2 HGNC:7421 ENTREZ:4513 UNIPROT:P00403 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO2"/> <bbox w="80.0" h="40.0" x="2275.75" y="5074.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3829_sa2850" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29036 CAS:15158-11-9 Identifiers_end </body> </html> </notes> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="2503.75" y="5056.0"/> </glyph> <glyph class="nucleic acid feature" id="s3830_sa2851" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin G2 HUGO:CCNG2 HGNC:1593 ENTREZ:901 UNIPROT:Q16589 Identifiers_end </body> </html> </notes> <label text="CyclinG2*"/> <bbox w="70.0" h="25.0" x="4408.0" y="7350.5"/> </glyph> <glyph class="nucleic acid feature" id="s3831_sa2852" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin G2 HUGO:CCNG2 HGNC:1593 ENTREZ:901 UNIPROT:Q16589 Identifiers_end </body> </html> </notes> <label text="CyclinG2*"/> <bbox w="90.0" h="25.0" x="4390.7593" y="7082.598"/> <glyph class="unit of information" id="_5ada97ff-b05f-47f3-89ee-c16e01033a99"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4425.7593" y="7077.598"/> </glyph> </glyph> <glyph class="phenotype" id="s3832_sa2853" compartmentRef="c13_ca13"> <label text="Cell cycle"/> <bbox w="80.0" h="30.0" x="4602.5" y="7450.0"/> </glyph> <glyph class="phenotype" id="s3833_sa2854" compartmentRef="c13_ca13"> <label text="Cell cycle~arrest"/> <bbox w="80.0" h="30.0" x="4602.5" y="7550.0"/> </glyph> <glyph class="macromolecule" id="s3834_sa2855" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin G2 HUGO:CCNG2 HGNC:1593 ENTREZ:901 UNIPROT:Q16589 Identifiers_end </body> </html> </notes> <label text="CyclinG2*"/> <bbox w="80.0" h="40.0" x="4472.5" y="7535.0"/> </glyph> <glyph class="macromolecule" id="s3835_sa2856" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c oxidase subunit Va HUGO:COX5A HGNC:2267 ENTREZ:9377 UNIPROT:P20674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5A"/> <bbox w="80.0" h="40.0" x="2860.0" y="3580.0"/> </glyph> <glyph class="nucleic acid feature" id="s3836_sa2857" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 449a HUGO:MIR449A HGNC:27645 ENTREZ:554213 microRNA 449b HUGO:MIR449B HGNC:32794 ENTREZ:693123 Identifiers_end </body> </html> </notes> <label text="MIR449*"/> <bbox w="90.0" h="25.0" x="3848.5" y="6678.0"/> <glyph class="unit of information" id="_0c602c8b-f8a4-4347-bf1b-92412fc4fbae"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3878.5" y="6673.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3837_sa2858" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 449a HUGO:MIR449A HGNC:27645 ENTREZ:554213 Identifiers_end </body> </html> </notes> <label text="MIR449A"/> <bbox w="90.0" h="25.0" x="3950.5" y="6630.0"/> <glyph class="unit of information" id="_9d99d907-1bdb-4cdf-9b58-8987e6c9d6b8"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3980.5" y="6625.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3838_sa2859" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 449b HUGO:MIR449B HGNC:32794 ENTREZ:693123 Identifiers_end </body> </html> </notes> <label text="MIR449B"/> <bbox w="90.0" h="25.0" x="3874.5" y="6631.0"/> <glyph class="unit of information" id="_ceaab440-d4aa-48bf-b4b1-00fc9522b0bb"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3904.5" y="6626.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3839_sa2860" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 20B HUGO:CDC20B HGNC:24222 ENTREZ:166979 UNIPROT:Q86Y33 Identifiers_end </body> </html> </notes> <label text="pre-mRNA~CDC20B*"/> <bbox w="90.0" h="25.0" x="4314.0" y="7081.5"/> <glyph class="unit of information" id="_c5eae3e5-97e7-4265-b0e1-47231832665b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4349.0" y="7076.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3840_sa2861" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 20B HUGO:CDC20B HGNC:24222 ENTREZ:166979 UNIPROT:Q86Y33 Identifiers_end </body> </html> </notes> <label text="CDC20B"/> <bbox w="70.0" h="25.0" x="4330.0" y="7345.5"/> </glyph> <glyph class="nucleic acid feature" id="s3841_sa2862" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 20B HUGO:CDC20B HGNC:24222 ENTREZ:166979 UNIPROT:Q86Y33 Identifiers_end </body> </html> </notes> <label text="CDC20B"/> <bbox w="90.0" h="25.0" x="4305.0" y="6937.5"/> <glyph class="unit of information" id="_57fea049-a9a5-4539-ba07-d505a70241dc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4340.0" y="6932.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3842_sa2863" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sirtuin 1 HUGO:SIRT1 HGNC:14929 ENTREZ:23411 UNIPROT:Q96EB6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="SIRT1"/> <bbox w="90.0" h="25.0" x="1750.5" y="7083.5"/> <glyph class="unit of information" id="_1277154b-4a62-4090-998a-55dcaab1270c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1785.5" y="7078.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3843_sa3351" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="5220.0" y="3590.0"/> <glyph class="state variable" id="_9ecdbe1c-86c2-4f95-91ad-2ff43d205d50"> <state value="?" variable="S15"/> <bbox w="30.0" h="10.0" x="5261.949" y="3585.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3846_sa2868" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDK6"/> <bbox w="90.0" h="25.0" x="4581.0" y="7039.5"/> <glyph class="unit of information" id="_74b65669-6d92-48e3-810e-d5aa1b5689e9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4616.0" y="7034.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3847_sa2869" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDK6"/> <bbox w="80.0" h="40.0" x="4342.5" y="7535.0"/> </glyph> <glyph class="macromolecule" id="s3849_sa2871" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene, E3 ubiquitin protein ligase HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="3632.5" y="7565.0"/> </glyph> <glyph class="macromolecule" id="s3850_sa2388" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: estrogen-related receptor alpha HUGO:ESRRA HGNC:3471 ENTREZ:2101 UNIPROT:P11474 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ESRRA"/> <bbox w="80.0" h="40.0" x="2560.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s3852_sa2361" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: estrogen-related receptor alpha HUGO:ESRRA HGNC:3471 ENTREZ:2101 UNIPROT:P11474 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ESRRA"/> <bbox w="90.0" h="25.0" x="2690.0" y="7076.75"/> <glyph class="unit of information" id="_d5b4e9f3-0ef2-4a8f-aad4-2f4841416657"> <label text="RNA"/> <bbox 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<body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="4690.0" y="7760.0"/> <glyph class="state variable" id="_c63b3ad7-cace-4142-b514-578e50d9cebd"> <state value="P" variable="T157"/> <bbox w="35.0" h="10.0" x="4695.9316" y="7755.0"/> </glyph> <glyph class="state variable" id="_7a864fa0-cc8f-46cc-8e0b-9858bebc79ec"> <state value="P" variable="T198"/> <bbox w="35.0" h="10.0" x="4729.449" y="7755.0"/> </glyph> </glyph> <glyph class="complex" id="s3857_csa319" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:p27KIP1* Identifiers_end </body> </html> </notes> <label text="14-3-3:CDKN1B"/> <bbox w="100.0" h="120.0" x="4320.0" y="6730.0"/> <glyph class="macromolecule" id="s3859_sa2877"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="4330.8276" y="6789.0"/> <glyph class="state variable" id="_d9bb90d9-a01f-4b5a-a7c1-42ffabe5262d"> <state value="P" variable="T157"/> <bbox w="35.0" h="10.0" x="4336.7593" y="6784.0"/> </glyph> <glyph class="state variable" id="_e93bd380-9258-4b7d-bb19-c87a17a24a43"> <state value="P" variable="T198"/> <bbox w="35.0" h="10.0" x="4370.277" y="6784.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3858_sa2878"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4330.0" y="6738.0"/> <glyph class="state variable" id="_2d3d459d-6663-466a-8802-c75214474f0b"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4379.0977" y="6733.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3860_sa2883" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin interacting protein HUGO:TXNIP HGNC:16952 ENTREZ:10628 UNIPROT:Q9H3M7 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TXNIP"/> <bbox w="80.0" h="40.0" x="11310.0" y="1870.0"/> <glyph class="state variable" id="_b24d0cd0-ea16-4ff2-a723-1aa730661eb8"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11356.568" y="1865.0"/> </glyph> </glyph> <glyph class="source and sink" id="s3862_sa2885" compartmentRef="c1_ca1"> <label text="s3862"/> <bbox w="30.0" h="30.0" x="11335.0" y="1955.0"/> </glyph> <glyph class="macromolecule" id="s3865_sa2890" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: itchy E3 ubiquitin protein ligase HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16469705 References_end </body> </html> </notes> <label text="ITCH"/> <clone/> <bbox w="80.0" h="40.0" x="4270.0" y="920.0"/> <glyph class="state variable" id="_50fbda05-c94a-4c22-ada1-a38cc4dd7c3d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4321.5684" y="915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3865_sa3638" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: itchy E3 ubiquitin protein ligase HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16469705 References_end </body> </html> </notes> <label text="ITCH"/> <clone/> <bbox w="80.0" h="40.0" x="11098.0" y="1811.0"/> <glyph class="state variable" id="_939e1ba8-de85-424b-b385-97133993f2c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11149.568" y="1806.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3865_sa3660" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: itchy E3 ubiquitin protein ligase HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16469705 References_end </body> </html> </notes> <label text="ITCH"/> <clone/> <bbox w="80.0" h="40.0" x="4340.0" y="1927.0"/> <glyph class="state variable" id="_571e6299-c478-445d-b78f-c02feeeb7cf8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4391.5684" y="1922.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3866_sa2891" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: itchy E3 ubiquitin protein ligase HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16469705 References_end </body> </html> </notes> <label text="ITCH"/> <clone/> <bbox w="80.0" h="40.0" x="4270.0" y="1010.0"/> <glyph class="state variable" id="_f66e690a-3f11-44f3-a3f5-4569cc39439e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4319.0684" y="1005.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3866_sa3663" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <clone/> <bbox w="80.0" h="40.0" x="9580.0" y="5310.0"/> </glyph> <glyph class="macromolecule" id="s3881_sa4788" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <clone/> <bbox w="80.0" h="40.0" x="9580.0" y="5220.0"/> </glyph> <glyph class="macromolecule" id="s3881_sa4841" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <clone/> <bbox w="80.0" h="40.0" x="9340.0" y="5080.0"/> </glyph> <glyph class="complex" id="s3884_csa323" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CFLAR:FADD:RIPK1:TRADD Identifiers_end </body> </html> </notes> <label text="CFLAR@complex II"/> <bbox w="198.0" h="129.0" x="4221.0" y="1275.5"/> <glyph class="macromolecule" id="s4911_sa2907"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CASP8 and FADD-like apoptosis regulator HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:15760909 PMID:19838173 PMID:26972597 FADD regulates NF-?B activation and 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References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. 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Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="4233.0" y="1335.5"/> <glyph class="state variable" id="_9d254e65-a14a-4d6f-ac3a-45596664924f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4228.0" y="1341.6711"/> </glyph> <glyph class="state variable" id="_3f69a887-38a0-411b-8202-a1e17b00b746"> <state value="" variable="K377"/> <bbox w="30.0" 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Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKFB3"/> <bbox w="80.0" h="40.0" x="1800.0" y="840.0"/> <glyph class="state variable" id="_d339af1d-45a8-404e-80ab-4cae4d48e9ae"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="1813.4314" y="835.0"/> </glyph> <glyph class="state variable" id="_5412c9da-e829-4850-8d96-581275ba7af8"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="1849.0686" y="835.0"/> </glyph> </glyph> <glyph class="complex" id="s3931_csa325" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC13*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8* Identifiers_end References_begin: anaphase promoting complex / cyclosome corresponds to species protein APC in the Rb/E2F map composition informations were retrieved from uniprot and PMID:9469815 References_end </body> </html> </notes> <label text="APC/C"/> <bbox w="340.0" h="160.0" x="3812.5" y="7865.0"/> <glyph class="macromolecule" id="s3911_sa2922"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11 HGNC:14452 ENTREZ:51529 UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="3822.5" y="7875.0"/> </glyph> <glyph class="macromolecule" id="s3912_sa2923"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10 HGNC:24077 ENTREZ:10393 UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="3822.5" y="7955.0"/> </glyph> <glyph class="macromolecule" id="s3898_sa2924"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 16 HUGO:CDC16 HGNC:1720 ENTREZ:8881 UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="4062.5" y="7915.0"/> </glyph> <glyph class="macromolecule" id="s3899_sa2925"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="4062.5" y="7955.0"/> </glyph> <glyph class="macromolecule" id="s3915_sa2926"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 1 HUGO:ANAPC1 HGNC:19988 ENTREZ:64682 UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="3902.5" y="7875.0"/> </glyph> <glyph class="macromolecule" id="s3916_sa2927"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4 HGNC:19990 ENTREZ:29945 UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="3902.5" y="7955.0"/> </glyph> <glyph class="macromolecule" id="s3917_sa2928"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5 HGNC:15713 ENTREZ:51433 UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="3822.5" y="7915.0"/> </glyph> <glyph class="macromolecule" id="s3903_sa2929"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 23 HUGO:CDC23 HGNC:1724 ENTREZ:8697 UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="3982.5" y="7915.0"/> </glyph> <glyph class="macromolecule" id="s3904_sa2930"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 27 HUGO:CDC27 HGNC:1728 ENTREZ:996 UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="3982.5" y="7875.0"/> </glyph> <glyph class="macromolecule" id="s3905_sa2931"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7 HGNC:17380 ENTREZ:51434 UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="3982.5" y="7955.0"/> </glyph> <glyph class="macromolecule" id="s3906_sa2932"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 13 HUGO:ANAPC13 HGNC:24540 ENTREZ:25847 UNIPROT:Q9BS18 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC13*"/> <bbox w="80.0" h="40.0" x="4062.5" y="7875.0"/> </glyph> <glyph class="macromolecule" id="s3922_sa2933"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 26 HUGO:CDC26 HGNC:17839 ENTREZ:246184 UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="3902.5" y="7915.0"/> </glyph> </glyph> <glyph class="complex" id="s3932_csa326" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC13*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:FZR1 Identifiers_end </body> </html> </notes> <label text="APC/C:CDH1"/> <bbox w="339.5" h="210.0" x="4242.75" y="7830.0"/> <glyph class="macromolecule" id="s4286_sa2934"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11 HGNC:14452 ENTREZ:51529 UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="4252.25" y="7850.0"/> </glyph> <glyph class="macromolecule" id="s4290_sa2935"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10 HGNC:24077 ENTREZ:10393 UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="4252.25" y="7930.0"/> </glyph> <glyph class="macromolecule" id="s3913_sa2936"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 16 HUGO:CDC16 HGNC:1720 ENTREZ:8881 UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="4252.25" y="7890.0"/> </glyph> <glyph class="macromolecule" id="s3914_sa2937"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="4252.25" y="7970.0"/> </glyph> <glyph class="macromolecule" id="s4285_sa2938"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 1 HUGO:ANAPC1 HGNC:19988 ENTREZ:64682 UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="4332.25" y="7850.0"/> </glyph> <glyph class="macromolecule" id="s4289_sa2939"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4 HGNC:19990 ENTREZ:29945 UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="4332.25" y="7930.0"/> </glyph> <glyph class="macromolecule" id="s4287_sa2940"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5 HGNC:15713 ENTREZ:51433 UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="4332.25" y="7890.0"/> </glyph> <glyph class="macromolecule" id="s3918_sa2941"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 23 HUGO:CDC23 HGNC:1724 ENTREZ:8697 UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="4332.25" y="7970.0"/> </glyph> <glyph class="macromolecule" id="s3919_sa2942"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 27 HUGO:CDC27 HGNC:1728 ENTREZ:996 UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="4412.25" y="7850.0"/> </glyph> <glyph class="macromolecule" id="s3920_sa2943"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7 HGNC:17380 ENTREZ:51434 UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="4412.25" y="7930.0"/> </glyph> <glyph class="macromolecule" id="s3921_sa2944"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: anaphase promoting complex subunit 13 HUGO:ANAPC13 HGNC:24540 ENTREZ:25847 UNIPROT:Q9BS18 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC13*"/> <bbox w="80.0" h="40.0" x="4412.25" y="7890.0"/> </glyph> <glyph class="macromolecule" id="s4288_sa2945"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cell division cycle 26 HUGO:CDC26 HGNC:17839 ENTREZ:246184 UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="4412.25" y="7970.0"/> </glyph> <glyph class="macromolecule" id="s4280_sa2948"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: fizzy/cell division cycle 20 related 1 (Drosophila) HUGO:FZR1 HGNC:24824 ENTREZ:51343 UNIPROT:Q9UM11 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM Maps_Modules_end References_begin: synonym:CDH1 References_end </body> </html> </notes> <label text="FZR1"/> <bbox w="80.0" h="40.0" x="4492.25" y="7850.0"/> <glyph class="state variable" id="_16518c59-2269-4e5d-beb7-d3212dc15be9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4543.8184" y="7845.0"/> </glyph> </glyph> </glyph> <glyph class="source and sink" id="s3935_sa2955" compartmentRef="c13_ca13"> <label text="s3935"/> <bbox w="30.0" h="30.0" x="3527.5" y="7760.0"/> </glyph> <glyph class="macromolecule" id="s3936_sa2954" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: uniprot:Q8N726 References_end </body> </html> </notes> <label text="p14ARF*"/> <bbox w="80.0" h="40.0" x="3392.5" y="7755.0"/> <glyph class="state variable" id="_e9c36820-33e0-48a7-ad79-9ac11cc71e69"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="3439.0686" y="7750.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3937_sa2956" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thyroid hormone receptor interactor 12 HUGO:TRIP12 HGNC:12306 ENTREZ:9320 UNIPROT:Q14669 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="TRIP12"/> <bbox w="80.0" h="40.0" x="3262.5" y="7795.0"/> </glyph> <glyph class="macromolecule" id="s3939_sa2958" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MAX interactor 1, dimerization protein HUGO:MXI1 HGNC:7534 ENTREZ:4601 UNIPROT:P50539 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MXI1"/> <bbox w="80.0" h="40.0" x="6532.5" y="7805.0"/> </glyph> <glyph class="complex" id="s3941_csa327" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAX:MXI1 Identifiers_end </body> </html> </notes> <label text="MAX:MXI1"/> <bbox w="100.0" h="120.0" x="6522.5" y="7615.0"/> <glyph class="macromolecule" id="s3943_sa2959"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MAX interactor 1, dimerization protein HUGO:MXI1 HGNC:7534 ENTREZ:4601 UNIPROT:P50539 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MXI1"/> <bbox w="80.0" h="40.0" x="6532.5" y="7665.0"/> </glyph> <glyph class="macromolecule" id="s3942_sa2960"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MYC associated factor X HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MAX"/> <bbox w="80.0" h="40.0" x="6532.5" y="7625.0"/> </glyph> </glyph> <glyph class="complex" id="s3947_csa328" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLX:MLXIP Identifiers_end </body> </html> </notes> <label text="MLX:MLXIP"/> <bbox w="97.5" h="120.0" x="6523.75" y="7475.0"/> <glyph class="macromolecule" id="s3949_sa2961"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MLX interacting protein HUGO:MLXIP HGNC:17055 ENTREZ:22877 UNIPROT:Q9HAP2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:MondoA References_end </body> </html> </notes> <label text="MLXIP"/> <bbox w="80.0" h="40.0" x="6532.5" y="7525.0"/> </glyph> <glyph class="macromolecule" id="s3950_sa2962"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MLX, MAX dimerization protein HUGO:MLX HGNC:11645 ENTREZ:6945 UNIPROT:Q9UH92 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLX"/> <bbox w="80.0" h="40.0" x="6532.5" y="7485.0"/> </glyph> </glyph> <glyph class="complex" id="s3948_csa329" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLX:MLXIP Identifiers_end </body> </html> </notes> <label text="MLX:MLXIP"/> <bbox w="100.0" h="120.0" x="5800.0" y="6020.0"/> <glyph class="macromolecule" id="s3944_sa2963"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MLX interacting protein HUGO:MLXIP HGNC:17055 ENTREZ:22877 UNIPROT:Q9HAP2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:MondoA References_end </body> </html> </notes> <label text="MLXIP"/> <bbox w="80.0" h="40.0" x="5810.0" y="6074.0"/> </glyph> <glyph class="macromolecule" id="s3946_sa2964"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MLX, MAX dimerization protein HUGO:MLX HGNC:11645 ENTREZ:6945 UNIPROT:Q9UH92 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLX"/> <bbox w="80.0" h="40.0" x="5808.0" y="6028.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3951_sa2965" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15721 KEGGCOMPOUND:C05382 CAS:2646-35-7 Identifiers_end </body> </html> </notes> <label text="sedoheptulose-7P"/> <clone/> <bbox w="125.0" h="22.5" x="960.0" y="1193.75"/> </glyph> <glyph class="simple chemical" id="s3951_sa3782" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15721 KEGGCOMPOUND:C05382 CAS:2646-35-7 Identifiers_end </body> </html> </notes> <label text="sedoheptulose-7P"/> <clone/> <bbox w="125.0" h="22.5" x="960.0" y="1243.75"/> </glyph> <glyph class="simple chemical" id="s3952_sa2966" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16332 KEGGCOMPOUND:C00231 CAS:60802-29-1 Identifiers_end </body> </html> </notes> <label text="xylulose-5P"/> <bbox w="87.5" h="27.5" x="826.25" y="886.25"/> </glyph> <glyph class="simple chemical" id="s3953_sa2967" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:48153 KEGGCOMPOUND:C00279 CAS:585-18-2 Identifiers_end </body> </html> </notes> <label text="erythrose-4P"/> <bbox w="95.0" h="32.5" x="912.5" y="1033.75"/> </glyph> <glyph class="macromolecule" id="s3954_sa2968" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glyceraldehyde-3-phosphate dehydrogenase HUGO:GAPDH HGNC:4141 ENTREZ:2597 UNIPROT:P04406 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic HUGO:GAPDHS HGNC:24864 ENTREZ:26330 UNIPROT:O14556 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="GAPDH*"/> <bbox w="80.0" h="40.0" x="1392.5" y="1465.0"/> </glyph> <glyph class="macromolecule" id="s3955_sa923" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic HUGO:GAPDHS HGNC:24864 ENTREZ:26330 UNIPROT:O14556 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: testis specific expression References_end </body> </html> </notes> <label text="GAPDHS"/> <bbox w="80.0" h="40.0" x="1542.5" y="1485.0"/> </glyph> <glyph class="macromolecule" id="s3958_sa2973" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: fructose-1,6-bisphosphatase 1 HUGO:FBP1 HGNC:3606 ENTREZ:2203 UNIPROT:P09467 fructose-1,6-bisphosphatase 2 HUGO:FBP2 HGNC:3607 ENTREZ:8789 UNIPROT:O00757 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="FBP*"/> <bbox w="80.0" h="40.0" x="1660.0" y="940.0"/> </glyph> <glyph class="macromolecule" id="s3959_sa2974" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transketolase HUGO:TKT HGNC:11834 ENTREZ:7086 UNIPROT:P29401 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKT"/> <bbox w="80.0" h="40.0" x="480.0" y="1420.0"/> </glyph> <glyph class="nucleic acid feature" id="s3960_sa2975" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transketolase HUGO:TKT HGNC:11834 ENTREZ:7086 UNIPROT:P29401 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKT"/> <bbox w="70.0" h="25.0" x="6782.8516" y="7311.4087"/> </glyph> <glyph class="nucleic acid feature" id="s3961_sa2976" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transketolase HUGO:TKT HGNC:11834 ENTREZ:7086 UNIPROT:P29401 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKT"/> <bbox w="90.0" h="25.0" x="6852.5" y="7064.5"/> <glyph class="unit of information" id="_9afd0ef6-909c-4566-af3e-216544aff493"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6887.5" y="7059.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3962_sa2977" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transketolase-like 1 HUGO:TKTL1 HGNC:11835 ENTREZ:8277 UNIPROT:P51854 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKTL1"/> <bbox w="80.0" h="40.0" x="960.0" y="810.0"/> </glyph> <glyph class="macromolecule" id="s3963_sa2978" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transketolase-like 2 HUGO:TKTL2 HGNC:25313 ENTREZ:84076 UNIPROT:Q9H0I9 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKTL2"/> <bbox w="80.0" h="40.0" x="380.0" y="1420.0"/> </glyph> <glyph class="macromolecule" id="s3964_sa2979" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transketolase HUGO:TKT HGNC:11834 ENTREZ:7086 UNIPROT:P29401 transketolase-like 2 HUGO:TKTL2 HGNC:25313 ENTREZ:84076 UNIPROT:Q9H0I9 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKT*"/> <bbox w="80.0" h="40.0" x="422.5" y="1347.0"/> </glyph> <glyph class="complex" id="s3965_csa330" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:TKT*:thiamine diphosphate Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKT"/> <bbox w="160.0" h="105.0" x="380.0" y="1077.5"/> <glyph class="simple chemical" id="s3967_sa2982"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:9532 KEGGCOMPOUND: C00068 CAS:154-87-0 </body> </html> </notes> <label text="thiamine diphosphate"/> <bbox w="145.5" h="23.5" x="387.25" y="1080.75"/> </glyph> <glyph class="simple chemical" id="s5922_sa2986"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end Maps_Modules_begin: MODULE:AKT_MTOR MODULE:MITOCH_METABOLISM MODULE:DEATH-RECEPTORS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Ca2+"/> <bbox w="75.0" h="40.5" x="372.5" y="1102.25"/> </glyph> <glyph class="macromolecule multimer" id="s4435_sa3394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transketolase HUGO:TKT HGNC:11834 ENTREZ:7086 UNIPROT:P29401 transketolase-like 2 HUGO:TKTL2 HGNC:25313 ENTREZ:84076 UNIPROT:Q9H0I9 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TKT*"/> <bbox w="86.0" h="46.0" x="437.0" y="1109.5"/> <glyph class="unit of information" id="_fb5b4ecb-97b1-47e5-9c97-8ca9a77bf774"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="470.0" y="1104.5"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s3971_sa2987" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transaldolase 1 HUGO:TALDO1 HGNC:11559 ENTREZ:6888 UNIPROT:P37837 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TALDO1"/> <bbox w="80.0" h="40.0" x="1232.5" y="1095.0"/> </glyph> <glyph class="macromolecule" id="s3972_sa2988" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribulose-5-phosphate-3-epimerase HUGO:RPE HGNC:10293 ENTREZ:6120 UNIPROT:Q96AT9 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="RPE"/> <bbox w="80.0" h="40.0" x="592.5" y="1075.0"/> </glyph> <glyph class="nucleic acid feature" id="s3973_sa2989" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin interacting protein HUGO:TXNIP HGNC:16952 ENTREZ:10628 UNIPROT:Q9H3M7 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TXNIP"/> <bbox w="70.0" h="25.0" x="6778.8516" y="7343.4087"/> </glyph> <glyph class="nucleic acid feature" id="s3974_sa2990" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin interacting protein HUGO:TXNIP HGNC:16952 ENTREZ:10628 UNIPROT:Q9H3M7 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="TXNIP"/> <bbox w="90.0" h="25.0" x="6838.5" y="7088.5"/> <glyph class="unit of information" id="_4d79b1f2-9e29-4b2a-8c13-a9c855057fcb"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6873.5" y="7083.5"/> </glyph> </glyph> <glyph class="complex" id="s3977_csa331" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DHODH:FMN Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="DHODH"/> <bbox w="92.0" h="98.0" x="558.25" y="4526.0"/> <glyph class="macromolecule" id="s3975_sa2991"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dihydroorotate dehydrogenase (quinone) HUGO:DHODH HGNC:2867 ENTREZ:1723 UNIPROT:Q02127 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="DHODH"/> <bbox w="80.0" h="40.0" x="566.25" y="4536.0"/> </glyph> <glyph class="simple chemical" id="s3976_sa2992"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:17621 KEGGCOMPOUND:C00061 CAS:146-17-8 </body> </html> </notes> <label text="FMN"/> <bbox w="70.0" h="25.0" x="571.25" y="4573.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s3978_sa2993" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17025 KEGGCOMPOUND:C00337 CAS:5988-19-2 Identifiers_end </body> </html> </notes> <label text="dihydroorotate"/> <bbox w="105.0" h="22.5" x="1131.25" y="3280.0"/> </glyph> <glyph class="simple chemical" id="s3979_sa2994" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16742 KEGGCOMPOUND:C00295 CAS:65-86-1 Identifiers_end </body> </html> </notes> <label text="orotate"/> <bbox w="70.0" h="25.0" x="1476.0" y="2811.0"/> </glyph> <glyph class="simple chemical" id="s3980_sa2995" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17025 KEGGCOMPOUND:C00337 CAS:5988-19-2 Identifiers_end </body> </html> </notes> <label text="dihydroorotate"/> <bbox w="70.0" h="25.0" x="539.25" y="4372.5"/> </glyph> <glyph class="simple chemical" id="s3981_sa2996" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16742 KEGGCOMPOUND:C00295 CAS:65-86-1 Identifiers_end </body> </html> </notes> <label text="orotate"/> <bbox w="70.0" h="25.0" x="669.25" y="4372.5"/> </glyph> <glyph class="simple chemical" id="s3983_sa412" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9 Identifiers_end </body> </html> </notes> <label text="NO"/> <bbox w="70.0" h="25.0" x="1802.25" y="5069.75"/> </glyph> <glyph class="nucleic acid feature" id="s3984_sa3002" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 107 HUGO:MIR107 HGNC:31496 ENTREZ:406901 Identifiers_end </body> </html> </notes> <label text="MIR107"/> <bbox w="90.0" h="25.0" x="2876.0" y="6681.5"/> <glyph class="unit of information" id="_4176ad6b-936a-4d4c-a878-690220989958"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2906.0" y="6676.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3985_sa3003" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pantothenate kinase 1 HUGO:PANK1 HGNC:8598 ENTREZ:53354 UNIPROT:Q8TE04 Identifiers_end </body> </html> </notes> <label text="PANK1"/> <bbox w="70.0" h="25.0" x="3257.3816" y="7328.367"/> </glyph> <glyph class="nucleic acid feature" id="s3986_sa3004" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pantothenate kinase 1 HUGO:PANK1 HGNC:8598 ENTREZ:53354 UNIPROT:Q8TE04 Identifiers_end </body> </html> </notes> <label text="pre-mRNA~PANK1*"/> <bbox w="90.0" h="25.0" x="3160.0" y="7081.75"/> <glyph class="unit of information" id="_f8f7ab32-3aca-46e5-b31c-3c653a342337"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3195.0" y="7076.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3987_sa3005" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pantothenate kinase 1 HUGO:PANK1 HGNC:8598 ENTREZ:53354 UNIPROT:Q8TE04 Identifiers_end </body> </html> </notes> <label text="PANK1"/> <bbox w="90.0" h="25.0" x="3025.0" y="6732.5"/> <glyph class="unit of information" id="_e705c69f-a794-4e30-a208-53256ba98c5a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3060.0" y="6727.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3988_sa3006" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aryl hydrocarbon receptor nuclear translocator HUGO:ARNT HGNC:700 ENTREZ:405 UNIPROT:P27540 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:HIF1beta References_end </body> </html> </notes> <label text="HIF1B*"/> <bbox w="90.0" h="25.0" x="3241.0" y="7080.75"/> <glyph class="unit of information" id="_38744552-6695-45fe-9059-6c30ea83daef"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3276.0" y="7075.75"/> </glyph> </glyph> <glyph class="complex" id="s3999_csa333" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNF:TNFRSF1A Identifiers_end References_begin: 21920725 References_end </body> </html> </notes> <label text="engaged~TNFRSF1A"/> <bbox w="112.0" h="154.0" x="4604.0" y="563.0"/> <glyph class="macromolecule multimer" id="s5984_sa3403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor HUGO:TNF HGNC:11892 ENTREZ:7124 UNIPROT:P01375 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TNF"/> <bbox w="86.0" h="46.0" x="4611.0" y="571.0"/> <glyph class="unit of information" id="_75a775fe-922d-4023-9b82-2f2194c42666"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="4644.0" y="566.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s5985_sa3405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor receptor superfamily, member 1A HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28765050 References_end </body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="86.0" h="56.0" x="4615.0" y="619.0"/> <glyph class="unit of information" id="_f8d6d938-61e9-44d6-ad11-7a737d831771"> <label text="N:3"/> <bbox w="20.0" h="10.0" x="4648.0" y="614.0"/> </glyph> <glyph class="unit of information" id="_23a05556-8d48-4253-b4ce-6804c70704bc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="4635.5" y="614.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4015_sa3011" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: K63-linked ubiquitin chain References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="5403.0" y="905.25"/> <glyph class="state variable" id="_7404eec0-3cff-458f-a4b1-4d98269be111"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5398.0" y="911.42114"/> </glyph> <glyph class="state variable" id="_313ac32f-9f9e-4f46-b201-efcdeece8ae8"> <state value="Ub" variable="K377"/> <bbox w="40.0" h="10.0" x="5463.0" y="911.5"/> </glyph> <glyph class="state variable" id="_f6f73864-ec7f-444a-9e7d-00f0c543a163"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5440.8364" y="900.25"/> </glyph> <glyph class="state variable" id="_84dc561b-99d3-4c53-aeed-66b2395887a6"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="5444.3306" y="940.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4016_sa3029" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:TAK1 PMID:23070005 References_end </body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="5825.0" y="454.5"/> <glyph class="state variable" id="_b08b2fc6-1688-4a30-97d3-d9096060c206"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5866.5684" y="449.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4017_sa3030" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="5609.1543" y="328.7367"/> </glyph> <glyph class="macromolecule" id="s4018_sa3031" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 3 HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TAB3"/> <bbox w="80.0" h="40.0" x="5709.1543" y="328.7367"/> </glyph> <glyph class="macromolecule" id="s4019_sa3032" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 TGF-beta activated kinase 1/MAP3K7 binding protein 3 HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TAB*"/> <bbox w="80.0" h="40.0" x="5659.1543" y="450.0"/> </glyph> <glyph class="macromolecule" id="s4021_sa3034" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <clone/> <bbox w="80.0" h="40.0" x="6000.0" y="450.0"/> </glyph> <glyph class="macromolecule" id="s4021_sa3933" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <clone/> <bbox w="80.0" h="40.0" x="6720.0" y="530.0"/> </glyph> <glyph class="macromolecule" id="s4024_sa3041" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: conserved helix-loop-helix ubiquitous kinase HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 IKBK-alpha synonym:IKBKA synonym:IKK_alpha_ Maps_Modules_end References_end </body> </html> </notes> <label text="CHUK"/> <bbox w="80.0" h="40.0" x="5905.0" y="335.0"/> </glyph> <glyph class="macromolecule" id="s4025_sa3229" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="5333.0" y="795.25"/> <glyph class="state variable" id="_1551fa7f-3afa-4070-a59f-3de474542f9a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5328.0" y="801.42114"/> </glyph> <glyph class="state variable" id="_ffba59a7-61b0-4761-8375-062980233b42"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="5398.0" y="801.5"/> </glyph> <glyph class="state variable" id="_38edd9f4-1b8f-4807-99bf-df53a963790c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5370.8364" y="790.25"/> </glyph> <glyph class="state variable" id="_df389b40-8b99-4921-9dff-61bab5c01e15"> <state value="P" variable="S161"/> <bbox w="35.0" h="10.0" x="5371.8306" y="830.25"/> </glyph> </glyph> <glyph class="complex" id="s4026_csa346" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FADD:RIPK1:TRADD Identifiers_end References_begin: 23010170 TRADD recruits FADD and caspase-8, forming complex IIA, where caspase-8 is activated and apoptosis is initiated References_end </body> </html> </notes> <label text="TNF complex II"/> <clone/> <bbox w="96.0" h="158.0" x="4493.0" y="1150.25"/> <glyph class="macromolecule" id="s4892_sa3220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TRADD"/> <clone/> <bbox w="80.0" h="40.0" x="4500.0" y="1200.25"/> </glyph> <glyph class="macromolecule" id="s4893_sa3221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="4498.0" y="1156.25"/> </glyph> <glyph class="macromolecule" id="s4913_sa3594"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <clone/> <bbox w="80.0" h="40.0" x="4499.8745" y="1241.588"/> <glyph class="state variable" id="_ff9d41cc-b6ae-4dc3-b0d3-4a58c8336d64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4494.8745" y="1247.7592"/> </glyph> <glyph class="state variable" id="_84d475f9-e04b-4eed-8309-8b9e45b65e8d"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="4564.8745" y="1247.838"/> </glyph> <glyph class="state variable" id="_8c61bfc4-4229-4012-98ce-3f0f183fec6d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4537.711" y="1236.588"/> </glyph> <glyph class="state variable" id="_53e0476a-dbdb-467f-8be0-a1148e795c68"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="4541.205" y="1276.588"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s4026_csa379" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FADD:RIPK1:TRADD Identifiers_end References_begin: 23010170 TRADD recruits FADD and caspase-8, forming complex IIA, where caspase-8 is activated and apoptosis is initiated References_end </body> </html> </notes> <label text="TNF complex II"/> <clone/> <bbox w="96.5" h="148.0" x="6382.25" y="1103.5"/> <glyph class="macromolecule" id="s4892_sa3668"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TRADD"/> <clone/> <bbox w="80.0" h="40.0" x="6389.25" y="1153.5"/> </glyph> <glyph class="macromolecule" id="s4893_sa3669"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="6387.25" y="1109.5"/> </glyph> <glyph class="macromolecule" id="s4913_sa3670"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <clone/> <bbox w="80.0" h="40.0" x="6389.1245" y="1194.838"/> <glyph class="state variable" id="_d33ee7f6-93fc-4a2f-96ef-94d3d26a5788"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6384.1245" y="1201.0092"/> </glyph> <glyph class="state variable" id="_761a8ea3-a611-454f-ab96-ae992df47598"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="6454.1245" y="1201.088"/> </glyph> <glyph class="state variable" id="_616270cf-cf3c-40e6-8a04-7b6408429dd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6426.961" y="1189.838"/> </glyph> <glyph class="state variable" id="_6cd1726a-6185-41ff-a7b5-b46d1d76daf1"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="6430.455" y="1229.838"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4027_sa118" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aconitase 2, mitochondrial HUGO:ACO2 HGNC:118 ENTREZ:50 UNIPROT:Q99798 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACO2"/> <bbox w="80.0" h="40.0" x="1446.5" y="6003.5"/> <glyph class="state variable" id="_602eb534-5dc3-4816-8dfc-0f030b650de2"> <state value="oxidized" variable=""/> <bbox w="50.0" h="10.0" x="1461.5" y="5998.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4028_sa126" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aconitase 2, mitochondrial HUGO:ACO2 HGNC:118 ENTREZ:50 UNIPROT:Q99798 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACO2"/> <bbox w="80.0" h="40.0" x="1285.0" y="6003.0"/> </glyph> <glyph class="macromolecule" id="s4031_sa2752" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially encoded cytochrome c oxidase II HUGO:MT-CO2 HGNC:7421 ENTREZ:4513 UNIPROT:P00403 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO2"/> <bbox w="80.0" h="40.0" x="2486.75" y="5105.0"/> </glyph> <glyph class="nucleic acid feature" id="s4033_sa2726" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitochondrially 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Celldesigner to SBGN-ML translation ------ Identifiers_begin: SCO2 cytochrome c oxidase assembly protein HUGO:SCO2 HGNC:10604 ENTREZ:9997 UNIPROT:O43819 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SCO2"/> <bbox w="80.0" h="40.0" x="2373.75" y="4953.5234"/> </glyph> <glyph class="nucleic acid feature" id="s4035_sa564" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SCO2 cytochrome c oxidase assembly protein HUGO:SCO2 HGNC:10604 ENTREZ:9997 UNIPROT:O43819 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SCO2"/> <bbox w="70.0" h="25.0" x="4002.0198" y="7299.3657"/> </glyph> <glyph class="nucleic acid feature" id="s4036_sa565" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SCO2 cytochrome c oxidase assembly protein HUGO:SCO2 HGNC:10604 ENTREZ:9997 UNIPROT:O43819 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="SCO2"/> <bbox w="90.0" h="25.0" x="3914.0" y="7081.5"/> <glyph class="unit of information" id="_4515e877-4f07-43ec-8b2f-36e2374383f1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3949.0" y="7076.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4037_sa877" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: enolase 2 (gamma, neuronal) HUGO:ENO2 HGNC:3353 ENTREZ:2026 UNIPROT:P09104 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ENO2"/> <bbox w="80.0" h="40.0" x="1496.7163" y="1994.8988"/> </glyph> <glyph class="nucleic acid feature" id="s4038_sa3044" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaminase 2 (liver, mitochondrial) HUGO:GLS2 HGNC:29570 ENTREZ:27165 UNIPROT:Q9UI32 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLS2"/> <bbox w="70.0" h="25.0" x="3664.1555" y="7336.558"/> </glyph> <glyph class="nucleic acid feature" id="s4039_sa3045" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutaminase 2 (liver, mitochondrial) HUGO:GLS2 HGNC:29570 ENTREZ:27165 UNIPROT:Q9UI32 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLS2"/> <bbox w="90.0" h="25.0" x="3714.0" y="7051.5"/> <glyph class="unit of information" id="_b54be663-5fb9-464a-b458-613560d155e9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3749.0" y="7046.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4040_sa3046" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peptidylprolyl isomerase A (cyclophilin A) HUGO:PPIA HGNC:9253 ENTREZ:5478 UNIPROT:P62937 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: synonym:cyclophilin A References_end </body> </html> </notes> <label text="PPIA"/> <bbox w="80.0" h="40.0" x="922.5" y="7225.0"/> </glyph> <glyph class="complex" id="s4041_csa334" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPIA:cleaved~AIFM1* Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="AIF:CypA"/> <bbox w="100.0" h="120.0" x="1113.0" y="7155.0"/> <glyph class="macromolecule" id="s4043_sa3047"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peptidylprolyl isomerase A (cyclophilin A) HUGO:PPIA HGNC:9253 ENTREZ:5478 UNIPROT:P62937 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: synonym:cyclophilin A References_end </body> </html> </notes> <label text="PPIA"/> <bbox w="80.0" h="40.0" x="1125.5" y="7213.0"/> </glyph> <glyph class="macromolecule" id="s4414_sa3048"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <bbox w="80.0" h="40.0" x="1122.5" y="7164.0"/> <glyph class="state variable" id="_7703a358-5e65-4b64-9c67-98f2e45304c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1174.0686" y="7159.0"/> </glyph> <glyph class="unit of information" id="_9552551f-5cb0-4b5d-96e3-c8c3891118b2"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1137.5" y="7159.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4045_sa3050" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: endonuclease G HUGO:ENDOG HGNC:3346 ENTREZ:2021 UNIPROT:Q14249 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="ENDOG"/> <bbox w="80.0" h="40.0" x="5230.0" y="6390.0"/> </glyph> <glyph class="nucleic acid feature" id="s4049_sa3059" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 4 HUGO:SLC2A4 HGNC:11009 ENTREZ:6517 UNIPROT:P14672 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT4 References_end </body> </html> </notes> <label text="SLC2A4"/> <bbox w="70.0" h="25.0" x="4727.0" y="7346.5"/> </glyph> <glyph class="nucleic acid feature" id="s4050_sa3060" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 2 (facilitated glucose transporter), member 4 HUGO:SLC2A4 HGNC:11009 ENTREZ:6517 UNIPROT:P14672 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:GLUT4 References_end </body> </html> </notes> <label text="SLC2A4"/> <bbox w="90.0" h="25.0" x="4780.0" y="7090.5"/> <glyph class="unit of information" id="_d1e60610-7843-4d22-acd8-dc9c890982f9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4815.0" y="7085.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4052_sa3259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase 4 HUGO:NOX4 HGNC:7891 ENTREZ:50507 UNIPROT:Q9NPH5 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX4"/> <bbox w="80.0" h="40.0" x="6680.0" y="1890.0"/> </glyph> <glyph class="macromolecule" id="s4053_sa3264" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase, EF-hand calcium binding domain 5 HUGO:NOX5 HGNC:14874 ENTREZ:79400 UNIPROT:Q96PH1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX5"/> <bbox w="80.0" h="40.0" x="6390.0" y="1980.0"/> </glyph> <glyph class="nucleic acid feature" id="s4054_sa3065" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA-damage regulated autophagy modulator 1 HUGO:DRAM1 HGNC:25645 ENTREZ:55332 UNIPROT:Q8N682 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="DRAM1"/> <bbox w="70.0" h="25.0" x="3997.0198" y="7334.3657"/> </glyph> <glyph class="nucleic acid feature" id="s4055_sa3066" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA-damage regulated autophagy modulator 1 HUGO:DRAM1 HGNC:25645 ENTREZ:55332 UNIPROT:Q8N682 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23030059 References_end </body> </html> </notes> <label text="DRAM1"/> <bbox w="90.0" h="25.0" x="4000.0" y="7052.5"/> <glyph class="unit of information" id="_bc519ab6-0c6d-4405-ba15-07b25294b502"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4035.0" y="7047.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4058_sa3271" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutrophil cytosolic factor 1 HUGO:NCF1 HGNC:7660 ENTREZ:653361 UNIPROT:P14598 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:p47phox synonym:NOXO2 References_end </body> </html> </notes> <label text="NCF1"/> <bbox w="90.0" h="40.0" x="6174.5" y="1832.5"/> </glyph> <glyph class="macromolecule" id="s4059_sa3070" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="cleaved~AKT1*"/> <bbox w="80.0" h="40.0" x="9150.0" y="1960.0"/> <glyph class="unit of information" id="_e2bb54eb-9c87-4d32-9b14-0ca8a1616d6f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9165.0" y="1955.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4060_sa3272" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutrophil cytosolic factor 1 HUGO:NCF1 HGNC:7660 ENTREZ:653361 UNIPROT:P14598 NADPH oxidase organizer 1 HUGO:NOXO1 HGNC:19404 ENTREZ:124056 UNIPROT:Q8NFA2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXO*"/> <bbox w="80.0" h="40.0" x="6212.0" y="1747.5"/> </glyph> <glyph class="macromolecule" id="s4061_sa3072" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM HGNC:795 ENTREZ:472 UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="cleaved~ATM*"/> <bbox w="80.0" h="40.0" x="872.5" y="7785.0"/> <glyph class="unit of information" id="_3da4ad25-56b2-4167-9bb1-18663e6dcc7d"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="887.5" y="7780.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4062_sa3073" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved~BAD*"/> <bbox w="80.0" h="40.0" x="3130.0" y="3160.0"/> <glyph class="unit of information" id="_e2700c02-6fa6-4a70-81a4-822201a19659"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3145.0" y="3155.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4063_sa1750" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="2986.75" y="2929.8584"/> <glyph class="state variable" id="_96667524-24f0-4447-9506-97b7f8262574"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3005.345" y="2924.8584"/> </glyph> <glyph class="state variable" id="_0fa56eee-32de-473e-922d-23cbe8321639"> <state value="" variable="S91"/> <bbox w="25.0" h="10.0" x="3031.1992" y="2924.8584"/> </glyph> </glyph> <glyph class="macromolecule" id="s4065_sa3075" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: baculoviral IAP repeat containing 2 HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490 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Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end References_begin: synonym:14-3-3 zeta References_end </body> </html> </notes> <label text="YWHAZ"/> <bbox w="80.0" h="40.0" x="7420.0" y="5044.0"/> </glyph> <glyph class="macromolecule" id="s4088_sa3103" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: synonym:14-3-3 epsilon PMID:11278287 References_end </body> </html> </notes> <label text="YWHAE"/> <clone/> <bbox w="80.0" h="40.0" x="7420.0" y="5090.0"/> </glyph> <glyph class="macromolecule" id="s4088_sa4259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: synonym:14-3-3 epsilon PMID:11278287 References_end </body> </html> </notes> <label text="YWHAE"/> <clone/> <bbox w="80.0" h="40.0" x="3820.0" y="520.0"/> </glyph> <glyph class="macromolecule" id="s4090_sa3105" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="YWHAB"/> <bbox w="80.0" h="40.0" x="7520.0" y="5150.0"/> </glyph> <glyph class="macromolecule" id="s4091_sa3106" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="SFN"/> <bbox w="80.0" h="40.0" x="7608.0" y="5006.0"/> </glyph> <glyph class="macromolecule" id="s4092_sa3107" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="YWHAG"/> <bbox w="80.0" h="40.0" x="7610.0" y="5050.0"/> </glyph> <glyph class="macromolecule" id="s4093_sa3108" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="YWHAH"/> <bbox w="80.0" h="40.0" x="7610.0" y="5094.0"/> </glyph> <glyph class="macromolecule" id="s4094_sa3109" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17604717 PMID:23030059 References_end </body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="8201.58" y="1716.955"/> <glyph class="state variable" id="_b380f348-8555-44cc-93df-314bae53bb79"> <state value="?" variable="T308"/> <bbox w="35.0" h="10.0" x="8204.521" y="1711.955"/> </glyph> <glyph class="state variable" id="_15b53786-d3bb-4f4b-935d-502709490600"> <state value="?" variable="S473"/> <bbox w="35.0" h="10.0" x="8243.639" y="1711.955"/> </glyph> </glyph> <glyph class="macromolecule" id="s4096_sa3110" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17604717 PMID:23030059 References_end </body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="8207.5" y="1880.0"/> <glyph class="state variable" id="_b7d6e35e-753c-4561-b5ae-fb9d970b1cd5"> <state value="unfolded" variable=""/> <bbox w="50.0" h="10.0" x="8222.5" y="1875.0"/> </glyph> <glyph class="state variable" id="_0230fd1e-1ec5-4903-b88b-7a86cdd0e1e6"> <state value="?" variable="T308"/> <bbox w="35.0" h="10.0" x="8210.441" y="1875.0"/> </glyph> <glyph class="state variable" id="_37bfea44-6163-4432-aa80-05b72fc63f5e"> <state value="?" variable="S473"/> <bbox w="35.0" h="10.0" x="8249.559" y="1875.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4097_sa1751" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:19942859 References_end </body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="80.0" h="40.0" x="3181.2678" y="2734.2468"/> </glyph> <glyph class="macromolecule" id="s4097_sa4493" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:19942859 References_end </body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="80.0" h="40.0" x="2124.0" y="971.0"/> </glyph> <glyph class="macromolecule" id="s4097_sa4494" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:19942859 References_end </body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="80.0" h="40.0" x="9761.027" y="3573.7634"/> </glyph> <glyph class="macromolecule" id="s4097_sa4498" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cAMP-dependent, catalytic, alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 protein kinase, cAMP-dependent, catalytic, beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 protein kinase, cAMP-dependent, catalytic, gamma HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:19942859 References_end </body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="80.0" h="40.0" x="9599.977" y="3576.9023"/> </glyph> <glyph class="macromolecule" id="s4098_sa3178" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 14 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_alpha_ References_end </body> </html> </notes> <label text="MAPK14"/> <clone/> <bbox w="80.0" h="40.0" x="5440.0" y="2040.0"/> </glyph> <glyph class="macromolecule" id="s4098_sa4835" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 14 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_alpha_ References_end </body> </html> </notes> <label text="MAPK14"/> <clone/> <bbox w="80.0" h="40.0" x="9240.0" y="5470.0"/> </glyph> <glyph class="complex" id="s4100_csa78" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:TSC1:TSC2 Identifiers_end </body> </html> </notes> <label text="14-3-3:TSC1:TSC2"/> <bbox w="173.0" h="149.0" x="8077.0" y="3071.0"/> <glyph class="macromolecule" id="s2079_sa1074"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="8164.6665" y="3082.3333"/> <glyph class="state variable" id="_3b7a69ed-61df-49a1-8330-0518547a1e26"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8213.765" y="3077.3333"/> </glyph> </glyph> <glyph class="macromolecule" id="s2078_sa1075"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8100.0" y="3140.0"/> <glyph class="state variable" id="_896a7288-05b3-4baf-bd3a-da25cb1b02c1"> <state value="P" variable="T1462"/> <bbox w="40.0" h="10.0" x="8136.949" y="3135.0"/> </glyph> <glyph class="state variable" id="_c70cd4c1-d804-40ea-8a34-86b8c15d5fb4"> <state value="P" variable="S939"/> <bbox w="35.0" h="10.0" x="8106.095" y="3135.0"/> </glyph> <glyph class="state variable" id="_c0fbf863-7616-43aa-884f-28bfacdc1d61"> <state value="" variable="S664"/> <bbox w="30.0" h="10.0" x="8085.0" y="3135.4395"/> </glyph> <glyph class="state variable" id="_6bfa70f6-8294-4272-90ea-8d34edadeed4"> <state value="" variable="S1345"/> <bbox w="35.0" h="10.0" x="8138.8306" y="3175.0"/> </glyph> <glyph class="state variable" id="_07ece6c1-0879-4a02-a0c3-61ee36b04874"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8095.0" y="3155.0"/> </glyph> <glyph class="state variable" id="_1b1b231e-53d6-401b-8d89-48ec8df5e07e"> <state value="" variable="S1798"/> <bbox w="35.0" h="10.0" x="8162.5" y="3135.5808"/> </glyph> <glyph class="state variable" id="_d5ff48cd-85cc-4120-ab10-ba85b3c4a396"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8175.0" y="3175.0"/> </glyph> <glyph class="state variable" id="_76e0d236-36cc-4788-b175-2f4ea54d5cf5"> <state value="" variable="S1341"/> <bbox w="35.0" h="10.0" x="8120.176" y="3175.0"/> </glyph> <glyph class="state variable" id="_dfac58e1-7bae-4104-be2d-6d3dda311210"> <state value="" variable="S1337"/> <bbox w="35.0" h="10.0" x="8103.2188" y="3175.0"/> </glyph> <glyph class="state variable" id="_0753cc53-02d2-4161-bede-46202ce3da99"> <state value="?" variable="M1"/> <bbox w="25.0" h="10.0" x="8087.5" y="3174.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="s4099_sa3111"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="8083.23" y="3081.9001"/> <glyph class="state variable" id="_8492cae0-2ea1-4451-b3e0-0656c4a665bf"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="8125.179" y="3076.9001"/> </glyph> <glyph class="state variable" id="_54ed3314-8f0a-4a76-83e2-d3f2e40c5832"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="8091.825" y="3076.9001"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4108_sa3183" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:JNK3 References_end </body> </html> </notes> <label text="JNK3*"/> <bbox w="80.0" h="40.0" x="4390.0" y="1997.0"/> </glyph> <glyph class="macromolecule" id="s4109_sa3174" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: JNK1, SAPK1 PMID:23850759 PMID:18191217 PMID:26587781 synonym:JNK1 PMID:17603935 PMID:19037093 References_end </body> </html> </notes> <label text="JNK1*"/> <clone/> <bbox w="80.0" h="40.0" x="4210.0" y="1997.0"/> <glyph class="state variable" id="_1038ef63-a79c-49c8-851c-9cb8754c3b34"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4228.4316" y="1992.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4109_sa4726" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: JNK1, SAPK1 PMID:23850759 PMID:18191217 PMID:26587781 synonym:JNK1 PMID:17603935 PMID:19037093 References_end </body> </html> </notes> <label text="JNK1*"/> <clone/> <bbox w="80.0" h="40.0" x="9670.0" y="5380.0"/> <glyph class="state variable" id="_93fd293f-d603-43a2-b3fa-d41be6244a50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9688.432" y="5375.0"/> </glyph> </glyph> <glyph class="complex" id="s4113_csa335" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAG4:TNFRSF1A Identifiers_end </body> </html> </notes> <label text="BAG4:TNFRSF1A"/> <bbox w="100.0" h="130.0" x="4410.0" y="205.0"/> <glyph class="macromolecule" id="s4150_sa3114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated athanogene 4 HUGO:BAG4 HGNC:940 ENTREZ:9530 UNIPROT:O95429 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:SODD References_end </body> </html> </notes> <label text="BAG4"/> <bbox w="80.0" h="40.0" x="4420.0" y="265.0"/> </glyph> <glyph class="macromolecule" id="s4117_sa3115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor receptor superfamily, member 1A HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28765050 References_end </body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="80.0" h="50.0" x="4421.0" y="213.5"/> <glyph class="unit of information" id="_b00b3a8f-e31c-4db6-a5ca-2c8074c6da2e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="4438.5" y="208.5"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4116_sa3163" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <clone/> <bbox w="80.0" h="40.0" x="4820.0" y="1450.0"/> <glyph class="state variable" id="_1f75066a-2e9a-4dad-b804-7dc5bce5ade6"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="4828.595" y="1445.0"/> </glyph> <glyph class="state variable" id="_e234bbe8-3ba2-4cb3-b848-d8aa1391d1f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4871.5684" y="1445.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4116_sa4725" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <clone/> <bbox w="80.0" h="40.0" x="9420.0" y="5260.0"/> <glyph class="state variable" id="_e269990f-8082-46ac-a9b6-1c1c1d77e753"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="9428.595" y="5255.0"/> </glyph> <glyph class="state variable" id="_ff97a7a6-d7cc-48bd-9c53-f36e03b798b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9471.568" y="5255.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4118_sa3112" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor receptor superfamily, member 1A HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28765050 References_end </body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="80.0" h="50.0" x="4540.0" y="205.0"/> <glyph class="unit of information" id="_00046b02-e03e-4a04-95b6-cbf3332cfaa1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="4557.5" y="200.0"/> </glyph> </glyph> <glyph class="source and sink" id="s4121_sa3291" compartmentRef="c1_ca1"> <label text="s4121"/> <bbox w="30.0" h="30.0" x="5889.5" y="1367.0"/> </glyph> <glyph class="macromolecule" id="s4122_sa3290" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha HUGO:NFKBIA HGNC:7797 ENTREZ:4792 UNIPROT:P25963 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:I_kappa_B-_alpha_ References_end </body> </html> </notes> <label text="NFKBIA"/> <bbox w="80.0" h="40.0" x="5864.5" y="1272.0"/> <glyph class="state variable" id="_8178f428-8e87-4eb4-8ac7-5852e44a3d91"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5877.9316" y="1267.0"/> </glyph> <glyph class="state variable" id="_73f8628b-d250-4ae4-9e2a-480006bf3380"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5913.5684" y="1267.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4151_sa3160" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="4630.0" y="1450.0"/> <glyph class="state variable" id="_574a295e-46af-4104-b622-88f6894bc1ab"> <state value="P" variable="S967"/> <bbox w="35.0" h="10.0" x="4636.095" y="1445.0"/> </glyph> <glyph class="state variable" id="_be0f12bf-c68e-4a28-912b-4f7f3890ec90"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4679.0684" y="1445.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4153_sa3164" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 5, catalytic subunit HUGO:PPP5C HGNC:9322 ENTREZ:5536 UNIPROT:P53041 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="PPP5C"/> <bbox w="80.0" h="40.0" x="4930.0" y="1550.0"/> </glyph> <glyph class="macromolecule" id="s4154_sa3167" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 3 HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKK3 synonym:MEK3 References_end </body> </html> </notes> <label text="MAP2K3"/> <bbox w="80.0" h="40.0" x="4908.0" y="1971.0"/> <glyph class="state variable" id="_fb6a005a-b46a-4219-a817-b14e60520c6a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4959.5684" y="1966.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4155_sa3168" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 6 HUGO:MAP2K6 HGNC:6846 ENTREZ:5608 UNIPROT:P52564 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKK6 References_end </body> </html> </notes> <label text="MAP2K6"/> <bbox w="80.0" h="40.0" x="4910.0" y="2023.0"/> <glyph class="state variable" id="_9e9ca970-3508-4df6-9dee-c64523efcb39"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4961.5684" y="2018.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4156_sa3169" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 4 HUGO:MAP2K4 HGNC:6844 ENTREZ:6416 UNIPROT:P45985 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:MKK4 synonym:MEK4 References_end </body> </html> </notes> <label text="MAP2K4"/> <bbox w="80.0" h="40.0" x="5098.5" y="1916.0"/> <glyph class="state variable" id="_2a9bb16e-0374-473e-84dc-afb9b124fdaa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5147.5684" y="1911.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4157_sa3170" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 6 HUGO:MAP2K6 HGNC:6846 ENTREZ:5608 UNIPROT:P52564 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKK6 References_end </body> </html> </notes> <label text="MAP2K6"/> <bbox w="80.0" h="40.0" x="5099.5" y="2022.0"/> <glyph class="state variable" id="_594d8643-6b8c-43b4-9e99-39728a9f4d15"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5148.5684" y="2017.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4158_sa3171" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 3 HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKK3 synonym:MEK3 References_end </body> </html> </notes> <label text="MAP2K3"/> <bbox w="80.0" h="40.0" x="5098.5" y="1969.0"/> <glyph class="state variable" id="_ba674edc-c63b-4241-b3c2-b69bfcfd33d5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5147.5684" y="1964.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4159_sa4275" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 7 HUGO:MAP2K7 HGNC:6847 ENTREZ:5609 UNIPROT:O14733 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:MKK7 PMID:17496911 References_end </body> </html> </notes> <label text="MAP2K7"/> <bbox w="80.0" h="40.0" x="4907.5" y="1858.0"/> <glyph class="state variable" id="_638646db-9381-4c0c-8234-3bd67a6ffdce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4959.0684" y="1853.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4160_sa3173" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF receptor-associated factor 6, E3 ubiquitin protein ligase HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16252010 References_end </body> </html> </notes> <label text="TRAF6"/> <clone/> <bbox w="80.0" h="40.0" x="5057.0" y="1297.0"/> </glyph> <glyph class="macromolecule" id="s4160_sa4297" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF receptor-associated factor 6, E3 ubiquitin protein ligase HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16252010 References_end </body> </html> </notes> <label text="TRAF6"/> <clone/> <bbox w="80.0" h="40.0" x="3900.0" y="660.0"/> </glyph> <glyph class="macromolecule" id="s4161_sa3175" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:JNK1 synonym:JNK2 synonym:JNK3 References_end </body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="4300.0" y="2187.0"/> <glyph class="state variable" id="_03ec4586-a405-40d9-8bc6-147d1ca87e3b"> <state value="" variable="T183"/> <bbox w="30.0" h="10.0" x="4308.595" y="2182.0"/> </glyph> <glyph class="state variable" id="_7b010256-5ed6-4d0a-bfc1-8ac059bdcafe"> <state value="P" variable="Y185"/> <bbox w="35.0" h="10.0" x="4339.449" y="2182.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4162_sa3176" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual specificity phosphatase 1 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 dual specificity phosphatase 16 HUGO:DUSP16 HGNC:17909 ENTREZ:80824 UNIPROT:Q9BY84 dual specificity phosphatase 6 HUGO:DUSP6 HGNC:3072 ENTREZ:1848 UNIPROT:Q16828 dual specificity phosphatase 10 HUGO:DUSP10 HGNC:3065 ENTREZ:11221 UNIPROT:Q9Y6W6 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:MKP1 6 synonym:MKP7 synonym:MKP3 0 synonym:MKP5 References_end </body> </html> </notes> <label text="DUSP*"/> <bbox w="80.0" h="40.0" x="5250.0" y="2250.0"/> </glyph> <glyph class="macromolecule" id="s4163_sa3177" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_beta_ References_end </body> </html> </notes> <label text="MAPK11"/> <clone/> <bbox w="80.0" h="40.0" x="5439.0" y="2085.0"/> </glyph> <glyph class="macromolecule" id="s4163_sa4832" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_beta_ References_end </body> </html> </notes> <label text="MAPK11"/> <clone/> <bbox w="80.0" h="40.0" x="9250.0" y="5350.0"/> </glyph> <glyph class="macromolecule" id="s4164_sa3179" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:JNK2 References_end </body> </html> </notes> <label text="JNK2*"/> <bbox w="80.0" h="40.0" x="4300.0" y="1997.0"/> </glyph> <glyph class="macromolecule" id="s4165_sa3182" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_delta_ References_end </body> </html> </notes> <label text="MAPK13"/> <clone/> <bbox w="80.0" h="40.0" x="5439.0" y="2130.0"/> </glyph> <glyph class="macromolecule" id="s4165_sa4834" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_delta_ References_end </body> </html> </notes> <label text="MAPK13"/> <clone/> <bbox w="80.0" h="40.0" x="9240.0" y="5530.0"/> </glyph> <glyph class="macromolecule" id="s4166_sa3184" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 12 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_gamma_ References_end </body> </html> </notes> <label text="MAPK12"/> <clone/> <bbox w="80.0" h="40.0" x="5440.0" y="2174.0"/> </glyph> <glyph class="macromolecule" id="s4166_sa4833" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 12 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:p38_gamma_ References_end </body> </html> </notes> <label text="MAPK12"/> <clone/> <bbox w="80.0" h="40.0" x="9290.0" y="5300.0"/> </glyph> <glyph class="macromolecule" id="s4167_sa3185" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:p38_beta_ synonym:p38_gamma_ synonym:p38_delta_ synonym:p38 References_end </body> </html> </notes> <label text="p38*"/> <bbox w="80.0" h="40.0" x="5320.0" y="2110.0"/> <glyph class="state variable" id="_3c1279d5-b7cf-41ca-8b81-0fce0950991c"> <state value="" variable="Y182"/> <bbox w="30.0" h="10.0" x="5361.949" y="2105.0"/> </glyph> <glyph class="state variable" id="_b9044b97-4528-4c37-96f2-2568c946db5c"> <state value="" variable="T180"/> <bbox w="30.0" h="10.0" x="5328.595" y="2105.0"/> </glyph> </glyph> <glyph class="complex" id="s4168_csa341" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:ASK1* Identifiers_end </body> </html> </notes> <label text="14-3-3:MAP3K5"/> <bbox w="96.0" h="134.0" x="4462.0" y="1513.0"/> <glyph class="macromolecule" id="s39_sa3187"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4468.0" y="1527.0"/> <glyph class="state variable" id="_78a542c6-333f-48be-a243-14cb5e82ed7e"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4517.0977" y="1522.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s38_sa3188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="4468.0" y="1577.0"/> <glyph class="state variable" id="_1e14e857-b260-4c7e-ba60-865014294aa2"> <state value="P" variable="S967"/> <bbox w="35.0" h="10.0" x="4474.095" y="1572.0"/> </glyph> <glyph class="state variable" id="_53c89307-feb6-4637-954c-4e5fc06fc15e"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4517.0684" y="1572.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s4169_csa342" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ASK1*:TXN Identifiers_end </body> </html> </notes> <label text="MAP3K5:TXN"/> <bbox w="100.0" h="120.0" x="4810.0" y="1580.0"/> <glyph class="macromolecule" id="s4115_sa3189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:15967 KEGGCOMPOUND: C00342 CAS:52500-60-4 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <bbox w="80.0" h="40.0" x="4819.5" y="1632.75"/> </glyph> <glyph class="macromolecule" id="s4178_sa3190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="4819.0" y="1590.25"/> <glyph class="state variable" id="_47f36c6c-beb4-4007-8712-baea158d265b"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="4827.595" y="1585.25"/> </glyph> <glyph class="state variable" id="_8f7229ba-1ebb-4d20-9d22-bf6e38057c42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4870.5684" y="1585.25"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s4171_csa345" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAB2IP:TRADD:TRAF2 Identifiers_end References_begin: 22743059 Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling. 18292600 AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation. References_end </body> </html> </notes> <label text="DAB2IP:TRADD:TRAF2"/> <bbox w="100.0" h="163.0" x="4844.5" y="1150.5"/> <glyph class="macromolecule" id="s4089_sa3197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TRADD"/> <bbox w="80.0" h="40.0" x="4853.5" y="1161.5"/> </glyph> <glyph class="macromolecule" id="s4176_sa3198"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <bbox w="80.0" h="40.0" x="4854.5" y="1207.5"/> </glyph> <glyph class="macromolecule" id="s4179_sa3199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DAB2 interacting protein HUGO:DAB2IP HGNC:17294 ENTREZ:153090 UNIPROT:Q5VWQ8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:AIP1 PMID:15310755 AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation References_end </body> </html> </notes> <label text="DAB2IP"/> <bbox w="80.0" h="40.0" x="4854.0" y="1253.5"/> <glyph class="state variable" id="_737d85f8-fea6-4efc-ab73-5f54b930d402"> <state value="P" variable="S604"/> <bbox w="35.0" h="10.0" x="4893.449" y="1248.5"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4180_sa3200" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="cleaved~RIPK1*"/> <bbox w="80.0" h="40.0" x="5103.0" y="945.25"/> <glyph class="unit of information" id="_7c812a4c-f011-4aed-b43e-b9a9a93f3d36"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5118.0" y="940.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4186_sa3213" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 11 HUGO:RNF11 HGNC:10056 ENTREZ:26994 UNIPROT:Q9Y3C5 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RNF11"/> <bbox w="80.0" h="40.0" x="4400.0" y="740.0"/> </glyph> <glyph class="macromolecule" id="s4188_sa3215" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Tax1 (human T-cell leukemia virus type I) binding protein 1 HUGO:TAX1BP1 HGNC:11575 ENTREZ:8887 UNIPROT:Q86VP1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TAX1BP1"/> <bbox w="80.0" h="40.0" x="4400.0" y="820.0"/> </glyph> <glyph class="source and sink" id="s4190_sa3217" compartmentRef="c12_ca14"> <label text="s9"/> <bbox w="30.0" h="30.0" x="4838.0" y="800.25"/> </glyph> <glyph class="macromolecule" id="s4191_sa3219" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="4510.0" y="1410.0"/> </glyph> <glyph class="macromolecule" id="s4191_sa3714" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="2840.0" y="1360.0"/> </glyph> <glyph class="macromolecule" id="s4191_sa3834" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="6580.0" y="330.0"/> </glyph> <glyph class="macromolecule" id="s4191_sa4097" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="8247.5" y="525.0"/> </glyph> <glyph class="macromolecule" id="s4191_sa4458" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="11450.929" y="2254.2144"/> </glyph> <glyph class="macromolecule" id="s4191_sa4862" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <clone/> <bbox w="80.0" h="40.0" x="10848.214" y="5799.2856"/> </glyph> <glyph class="macromolecule" id="s4202_sa3231" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="cleaved~RIPK3*"/> <bbox w="80.0" h="40.0" x="4629.0" y="937.25"/> <glyph class="unit of information" id="_bcb70a36-be70-4f1e-8843-67958237536a"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4644.0" y="932.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4204_sa2061" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="1510.0" y="3380.0"/> <glyph class="state variable" id="_12627067-3080-4190-b168-224c89594daa"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="1495.4926" y="3375.0"/> </glyph> <glyph class="state variable" id="_b0100e05-cbce-4c42-8d66-48bda7142c45"> <state value="P" variable="S199"/> <bbox w="35.0" h="10.0" x="1549.4493" y="3375.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4205_sa3233" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:TAK1 PMID:23070005 References_end </body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="5875.5" y="700.25"/> <glyph class="state variable" id="_7ab87176-0621-4090-906a-4c00a7c25f69"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="5914.5684" y="695.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4206_sa3234" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 6, catalytic subunit HUGO:PPP6C HGNC:9323 ENTREZ:5537 UNIPROT:O00743 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PPP6C"/> <bbox w="80.0" h="40.0" x="6400.0" y="660.0"/> </glyph> <glyph class="macromolecule" id="s4217_sa3245" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: riboflavin kinase HUGO:RFK HGNC:30324 ENTREZ:55312 UNIPROT:Q969G6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RFK"/> <bbox w="80.0" h="40.0" x="6100.0" y="450.0"/> </glyph> <glyph class="simple chemical" id="s4219_sa3248" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17015 KEGGCOMPOUND:C00255 CAS:83-88-5 Identifiers_end </body> </html> </notes> <label text="riboflavin"/> <bbox w="70.0" h="25.0" x="6075.0" y="317.5"/> </glyph> <glyph class="simple chemical" id="s4220_sa3249" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17621 Identifiers_end </body> </html> </notes> <label text="FMN"/> <bbox w="70.0" h="25.0" x="6088.0" y="742.75"/> </glyph> <glyph class="macromolecule" id="s4221_sa3251" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: flavin adenine dinucleotide synthetase 1 HUGO:FLAD1 HGNC:24671 ENTREZ:80308 UNIPROT:Q8NFF5 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="FLAD1"/> <bbox w="80.0" h="40.0" x="6280.0" y="450.0"/> </glyph> <glyph class="simple chemical" id="s4222_sa3252" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16238 Identifiers_end </body> </html> </notes> <label text="FAD"/> <bbox w="70.0" h="25.0" x="6258.0" y="742.75"/> </glyph> <glyph class="macromolecule" id="s4226_sa3260" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase 3 HUGO:NOX3 HGNC:7890 ENTREZ:50508 UNIPROT:Q9HBY0 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX3"/> <bbox w="80.0" h="40.0" x="6452.0" y="1847.5"/> </glyph> <glyph class="macromolecule" id="s4227_sa3261" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome b-245, beta polypeptide HUGO:CYBB HGNC:2578 ENTREZ:1536 UNIPROT:P04839 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:NOX2 synonym:gp91phox References_end </body> </html> </notes> <label text="CYBB"/> <bbox w="80.0" h="40.0" x="6452.0" y="1747.5"/> </glyph> <glyph class="macromolecule" id="s4228_sa3262" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase 1 HUGO:NOX1 HGNC:7889 ENTREZ:27035 UNIPROT:Q9Y5S8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX1"/> <bbox w="80.0" h="40.0" x="6452.0" y="1797.5"/> </glyph> <glyph class="macromolecule" id="s4230_sa3266" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC2 HGNC:9802 ENTREZ:5880 UNIPROT:P15153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RAC2"/> <bbox w="80.0" h="40.0" x="6040.0" y="1790.0"/> </glyph> <glyph class="macromolecule" id="s4231_sa3267" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11756498 PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1"/> <clone/> <bbox w="80.0" h="40.0" x="5950.0" y="1790.0"/> </glyph> <glyph class="macromolecule" id="s4231_sa4264" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11756498 PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1"/> <clone/> <bbox w="80.0" h="40.0" x="2852.0" y="591.0"/> </glyph> <glyph class="macromolecule" id="s4232_sa3269" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome b-245, alpha polypeptide HUGO:CYBA HGNC:2577 ENTREZ:1535 UNIPROT:P13498 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:p22phox References_end </body> </html> </notes> <label text="CYBA"/> <bbox w="80.0" h="40.0" x="6572.0" y="1727.5"/> </glyph> <glyph class="macromolecule" id="s4233_sa3270" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase 1 HUGO:NOX1 HGNC:7889 ENTREZ:27035 UNIPROT:Q9Y5S8 cytochrome b-245, beta polypeptide HUGO:CYBB HGNC:2578 ENTREZ:1536 UNIPROT:P04839 NADPH oxidase 3 HUGO:NOX3 HGNC:7890 ENTREZ:50508 UNIPROT:Q9HBY0 NADPH oxidase 4 HUGO:NOX4 HGNC:7891 ENTREZ:50507 UNIPROT:Q9NPH5 NADPH oxidase, EF-hand calcium binding domain 5 HUGO:NOX5 HGNC:14874 ENTREZ:79400 UNIPROT:Q96PH1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX*"/> <bbox w="80.0" h="40.0" x="6566.0" y="1798.5"/> </glyph> <glyph class="macromolecule" id="s4234_sa3273" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase organizer 1 HUGO:NOXO1 HGNC:19404 ENTREZ:124056 UNIPROT:Q8NFA2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXO1"/> <bbox w="80.0" h="40.0" x="6269.5" y="1832.5"/> </glyph> <glyph class="macromolecule" id="s4235_sa3274" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutrophil cytosolic factor 2 HUGO:NCF2 HGNC:7661 ENTREZ:4688 UNIPROT:P19878 NADPH oxidase activator 1 HUGO:NOXA1 HGNC:10668 ENTREZ:10811 UNIPROT:Q86UR1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXA*"/> <clone/> <bbox w="80.0" h="40.0" x="6042.0" y="1877.5"/> </glyph> <glyph class="macromolecule" id="s4235_sa4893" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutrophil cytosolic factor 2 HUGO:NCF2 HGNC:7661 ENTREZ:4688 UNIPROT:P19878 NADPH oxidase activator 1 HUGO:NOXA1 HGNC:10668 ENTREZ:10811 UNIPROT:Q86UR1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXA*"/> <clone/> <bbox w="80.0" h="40.0" x="10510.0" y="6850.0"/> </glyph> <glyph class="macromolecule" id="s4236_sa3275" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutrophil cytosolic factor 2 HUGO:NCF2 HGNC:7661 ENTREZ:4688 UNIPROT:P19878 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:p67phox synonym:NOXA2 References_end </body> </html> </notes> <label text="NCF2"/> <bbox w="80.0" h="40.0" x="5999.5" y="1952.5"/> </glyph> <glyph class="macromolecule" id="s4237_sa3276" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADPH oxidase activator 1 HUGO:NOXA1 HGNC:10668 ENTREZ:10811 UNIPROT:Q86UR1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXA1"/> <bbox w="80.0" h="40.0" x="6110.0" y="1950.0"/> </glyph> <glyph class="complex" id="s4238_csa350" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:RAC1_2* Identifiers_end </body> </html> </notes> <label text="RAC:GDP"/> <bbox w="98.0" h="104.0" x="5980.5" y="1580.5"/> <glyph class="simple chemical" id="s4244_sa3277"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="5995.5" y="1636.0"/> </glyph> <glyph class="macromolecule" id="s4068_sa3278"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC2 HGNC:9802 ENTREZ:5880 UNIPROT:P15153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1_2*"/> <bbox w="80.0" h="40.0" x="5989.5" y="1587.5"/> </glyph> </glyph> <glyph class="complex" id="s4239_csa351" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:RAC1_2* Identifiers_end </body> </html> </notes> <label text="RAC:GTP"/> <bbox w="98.0" h="104.0" x="6160.5" y="1580.5"/> <glyph class="simple chemical" id="s4246_sa3279"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="6175.5" y="1636.0"/> </glyph> <glyph class="macromolecule" id="s4261_sa3280"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC2 HGNC:9802 ENTREZ:5880 UNIPROT:P15153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1_2*"/> <bbox w="80.0" h="40.0" x="6169.5" y="1587.5"/> </glyph> </glyph> <glyph class="complex" id="s4240_csa352" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:NOX5 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX5"/> <bbox w="116.0" h="85.0" x="6544.0" y="1935.0"/> <glyph class="macromolecule" id="s4249_sa3281"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADPH oxidase, EF-hand calcium binding domain 5 HUGO:NOX5 HGNC:14874 ENTREZ:79400 UNIPROT:Q96PH1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX5"/> <bbox w="80.0" h="40.0" x="6560.0" y="1960.0"/> </glyph> <glyph class="simple chemical" id="s4262_sa3282"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="6553.0" y="1938.0"/> </glyph> </glyph> <glyph class="complex" id="s4241_csa353" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CYBA:FAD:NOX*:NOXA*:NOXO*:RAC1_2*:heme Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NADPH oxidase"/> <bbox w="345.0" h="105.0" x="6347.0" y="1580.0"/> <glyph class="macromolecule" id="s4900_sa3283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADPH oxidase 1 HUGO:NOX1 HGNC:7889 ENTREZ:27035 UNIPROT:Q9Y5S8 cytochrome b-245, beta polypeptide HUGO:CYBB HGNC:2578 ENTREZ:1536 UNIPROT:P04839 NADPH oxidase 3 HUGO:NOX3 HGNC:7890 ENTREZ:50508 UNIPROT:Q9HBY0 NADPH oxidase 4 HUGO:NOX4 HGNC:7891 ENTREZ:50507 UNIPROT:Q9NPH5 NADPH oxidase, EF-hand calcium binding domain 5 HUGO:NOX5 HGNC:14874 ENTREZ:79400 UNIPROT:Q96PH1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX*"/> <bbox w="80.0" h="40.0" x="6597.0" y="1585.0"/> </glyph> <glyph class="macromolecule" id="s4901_sa3284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome b-245, alpha polypeptide HUGO:CYBA HGNC:2577 ENTREZ:1535 UNIPROT:P13498 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:p22phox References_end </body> </html> </notes> <label text="CYBA"/> <bbox w="80.0" h="40.0" x="6597.0" y="1635.0"/> </glyph> <glyph class="simple chemical" id="s4902_sa3285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:30413 </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="6522.0" y="1592.5"/> </glyph> <glyph class="macromolecule" id="s4906_sa3286"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC2 HGNC:9802 ENTREZ:5880 UNIPROT:P15153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1_2*"/> <bbox w="80.0" h="40.0" x="6479.5" y="1622.5"/> </glyph> <glyph class="macromolecule" id="s4903_sa3287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: neutrophil cytosolic factor 1 HUGO:NCF1 HGNC:7660 ENTREZ:653361 UNIPROT:P14598 NADPH oxidase organizer 1 HUGO:NOXO1 HGNC:19404 ENTREZ:124056 UNIPROT:Q8NFA2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXO*"/> <bbox w="80.0" h="40.0" x="6357.0" y="1585.0"/> </glyph> <glyph class="macromolecule" id="s4904_sa3288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: neutrophil cytosolic factor 2 HUGO:NCF2 HGNC:7661 ENTREZ:4688 UNIPROT:P19878 NADPH oxidase activator 1 HUGO:NOXA1 HGNC:10668 ENTREZ:10811 UNIPROT:Q86UR1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXA*"/> <bbox w="80.0" h="40.0" x="6357.0" y="1635.0"/> </glyph> <glyph class="simple chemical" id="s4905_sa3289"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="6442.0" y="1592.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4264_sa3299" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NFKB1"/> <bbox w="80.0" h="40.0" x="5185.75" y="1335.7797"/> </glyph> <glyph class="macromolecule" id="s4272_sa3315" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="3462.5" y="2951.25"/> <glyph class="state variable" id="_8f452a07-e580-43a3-a6ff-d5af1c0d2545"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3511.5686" y="2946.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4273_sa3316" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DNA-damage regulated autophagy modulator 1 HUGO:DRAM1 HGNC:25645 ENTREZ:55332 UNIPROT:Q8N682 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="DRAM1"/> <bbox w="80.0" h="40.0" x="10924.0" y="3392.5"/> </glyph> <glyph class="macromolecule" id="s4274_sa3317" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AKT1"/> <clone/> <bbox w="80.0" h="40.0" x="9012.5" y="1956.0"/> </glyph> <glyph class="macromolecule" id="s4274_sa4602" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AKT1"/> <clone/> <bbox w="80.0" h="40.0" x="5520.0" y="6930.0"/> </glyph> <glyph class="macromolecule" id="s4275_sa3318" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="AKT2"/> <bbox w="80.0" h="40.0" x="9012.5" y="2000.0"/> </glyph> <glyph class="macromolecule" id="s4281_sa3319" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC HGNC:9413 ENTREZ:5591 UNIPROT:P78527 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="cleaved~DNA-PK*"/> <bbox w="80.0" h="40.0" x="772.5" y="7035.0"/> <glyph class="unit of information" id="_6351ca83-a313-4fdb-8b65-a61ce2dbeb10"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="787.5" y="7030.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s4282_sa3320" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 125b-2 HUGO:MIR125B2 HGNC:31507 ENTREZ:406912 Identifiers_end </body> </html> </notes> <label text="MIR125B2"/> <bbox w="90.0" h="25.0" x="6296.5" y="6639.5"/> <glyph class="unit of information" id="_ee4b8d8c-b20a-48dc-934e-5f9da6469a2a"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6326.5" y="6634.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s4283_sa3321" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 125b-1 HUGO:MIR125B1 HGNC:31506 ENTREZ:406911 microRNA 125b-2 HUGO:MIR125B2 HGNC:31507 ENTREZ:406912 Identifiers_end </body> </html> </notes> <label text="MIR125B*"/> <bbox w="90.0" h="25.0" x="6360.5" y="6683.5"/> <glyph class="unit of information" id="_366f50cb-a000-44da-bdf0-fa716f7ce179"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6390.5" y="6678.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s4284_sa3322" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: insulin-like growth factor binding protein 1 HUGO:IGFBP1 HGNC:5469 ENTREZ:3484 UNIPROT:P08833 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="IGFBP1"/> <bbox w="70.0" h="25.0" x="3584.1555" y="7306.558"/> </glyph> <glyph class="complex" id="s4291_csa287" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BACH1:heme Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1:heme"/> <bbox w="97.5" h="105.0" x="7432.5" y="7565.0"/> <glyph class="macromolecule" id="s4292_sa2331"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="7436.4365" y="7575.03"/> </glyph> <glyph class="simple chemical" id="s4293_sa2332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:30413 </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="7451.4365" y="7621.03"/> </glyph> </glyph> <glyph class="complex" id="s4294_csa290" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1"/> <bbox w="100.0" h="180.0" x="2840.0" y="7750.0"/> <glyph class="macromolecule" id="s4295_sa2345"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="2850.0" y="7800.0"/> </glyph> <glyph class="macromolecule" id="s4296_sa2346"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="2850.0" y="7850.0"/> <glyph class="state variable" id="_508b3f14-417c-4af4-9d49-0b55bcb87052"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="2891.9492" y="7845.0"/> </glyph> <glyph class="state variable" id="_aaf66491-b849-4f78-8ca8-14e7b9228d20"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="2858.595" y="7845.0"/> </glyph> <glyph class="state variable" id="_5a50898c-8082-475d-a791-a09519104c24"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="2865.9314" y="7885.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4297_sa2347"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="2850.0" y="7760.0"/> </glyph> </glyph> <glyph class="complex" id="s4298_csa357" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFKB1_p50*:RELA Identifiers_end </body> </html> </notes> <label text="RELA:p50"/> <bbox w="107.5" h="130.0" x="6338.75" y="7540.0"/> <glyph class="macromolecule" id="s4299_sa3312"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-rel reticuloendotheliosis viral oncogene homolog A (avian) HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RELA"/> <bbox w="80.0" h="40.0" x="6352.5" y="7595.0"/> <glyph class="state variable" id="_1757b3eb-5afe-4f29-b3e1-57f87a8cabf7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6370.9316" y="7630.0"/> </glyph> <glyph class="state variable" id="_cc229fd8-fdb2-4c25-82ce-b9e6e9816a99"> <state value="" variable="T254"/> <bbox 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compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5172.5" y="7935.0"/> </glyph> <glyph class="macromolecule" id="s4302_sa979" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 3 (acute-phase response factor) HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:28186502 References_end </body> </html> </notes> <label text="STAT3"/> <bbox w="80.0" h="40.0" x="3372.5" y="7475.0"/> <glyph class="state variable" id="_7d822e84-a3d0-4a0b-97bd-4dcc01d083e2"> <state value="?" variable="S727"/> <bbox w="35.0" h="10.0" x="3411.9492" y="7470.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s4305_sa1185" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16526 KEGGCOMPOUND:C00011 CAS:124-38-9 Identifiers_end References_begin: synonym:carbon dioxide charge:0 References_end </body> </html> </notes> <label text="CO2"/> <bbox w="70.0" h="25.0" x="5967.5" y="7832.5"/> </glyph> <glyph class="simple chemical" id="s4306_sa1186" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16810 KEGGCOMPOUND:C00026 CAS:64-15-3 Identifiers_end </body> </html> </notes> <label text="2-oxoglutarate"/> <bbox w="70.0" h="25.0" x="5967.5" y="7712.5"/> </glyph> <glyph class="simple chemical" id="s4307_sa1187" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15741 Identifiers_end </body> </html> </notes> <label text="succinate"/> <bbox w="70.0" h="25.0" x="5967.5" y="7802.5"/> </glyph> <glyph class="macromolecule" id="s4308_sa1236" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <clone/> <bbox w="80.0" h="40.0" x="7372.5" y="7845.0"/> <glyph class="state variable" id="_8cb1aa0c-4952-46e3-832f-4ec91e1e8695"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7424.0684" y="7840.0"/> </glyph> <glyph class="state variable" id="_1a2a340b-294c-4d5b-8ccd-ae9cc3ed51f7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7390.9316" y="7840.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4308_sa3573" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <clone/> <bbox w="80.0" h="40.0" x="7282.5" y="7475.0"/> <glyph class="state variable" id="_dbc86cbd-2ee1-4672-b01c-04c1ac4dc360"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7334.0684" y="7470.0"/> </glyph> <glyph class="state variable" id="_76c9cfb0-467b-4ae1-a731-e92040c6e592"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7300.9316" y="7470.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4310_sa1267" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: notch 1 HUGO:NOTCH1 HGNC:7881 ENTREZ:4851 UNIPROT:P46531 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: proteolytically activated NOTCH1 References_end </body> </html> </notes> <label text="N1ICD*"/> <bbox w="80.0" h="40.0" x="5402.5" y="7795.0"/> <glyph class="unit of information" id="_1883c525-44ad-489b-93e1-ea5605cd728a"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5417.5" y="7790.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4311_sa1269" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: YY1 transcription factor HUGO:YY1 HGNC:12856 ENTREZ:7528 UNIPROT:P25490 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="YY1"/> <bbox w="80.0" h="40.0" x="5342.5" y="7595.0"/> </glyph> <glyph class="macromolecule" id="s4312_sa1319" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase HUGO:HUWE1 HGNC:30892 ENTREZ:10075 UNIPROT:Q7Z6Z7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:MULE References_end </body> </html> </notes> <label text="HECTH9*"/> <bbox w="80.0" h="40.0" x="3532.5" y="7795.0"/> </glyph> <glyph class="macromolecule" id="s4313_sa1320" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:JNK1 synonym:JNK2 synonym:JNK3 References_end </body> </html> </notes> <label text="JNK*"/> <clone/> <bbox w="80.0" h="40.0" x="3990.0" y="7745.0"/> <glyph class="state variable" id="_5e4e4c30-dd1e-45ac-8616-505570e9b869"> <state value="P" variable="T183"/> <bbox w="35.0" h="10.0" x="3996.095" y="7740.0"/> </glyph> <glyph class="state variable" id="_b4dc96c5-797a-4e07-85d2-e58e80197d59"> <state value="P" variable="Y185"/> <bbox w="35.0" h="10.0" x="4029.4492" y="7740.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4313_sa3479" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:JNK1 synonym:JNK2 synonym:JNK3 References_end </body> </html> </notes> <label text="JNK*"/> <clone/> <bbox w="80.0" h="40.0" x="292.5" y="7325.0"/> <glyph class="state variable" id="_b3d9c5ce-7c46-4fb3-ac03-504e5f6f01ee"> <state value="P" variable="T183"/> <bbox w="35.0" h="10.0" x="298.59503" y="7320.0"/> </glyph> <glyph class="state variable" id="_dd167ab2-05ed-4aa3-8f82-a396b6dac7db"> <state value="P" variable="Y185"/> <bbox w="35.0" h="10.0" x="331.94928" y="7320.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4313_sa4272" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS 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MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="SIRT1"/> <bbox w="80.0" h="40.0" x="980.0" y="7320.0"/> </glyph> <glyph class="macromolecule" id="s4315_sa1365" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6 HGNC:4055 ENTREZ:2547 UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES 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merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <bbox w="80.0" h="40.0" x="922.5" y="7165.0"/> <glyph class="state variable" id="_7aad440f-7de1-45a2-bbcf-a0a4c6d0f87c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="974.06854" y="7160.0"/> </glyph> <glyph class="unit of information" id="_2e3803a4-6429-49c3-994e-9a8e3bea4a26"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="937.5" y="7160.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4326_sa2381" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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<head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC HGNC:9413 ENTREZ:5591 UNIPROT:P78527 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:DNAPK References_end </body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="772.5" y="7105.0"/> <glyph class="state variable" id="_4a40ad44-9098-4740-b49e-8143f6b52ca3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="824.06854" y="7100.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4332_sa3051" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> 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</head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <clone/> <bbox w="80.0" h="40.0" x="5070.0" 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MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <clone/> <bbox w="80.0" h="40.0" x="7469.0" y="488.0"/> <glyph class="state variable" id="_8212379d-9f72-4429-a0ec-e5b81850aad5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7464.0" y="494.17117"/> </glyph> <glyph class="state variable" id="_a0ef5ee2-4b2e-470a-9c6e-29a84bff5b55"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="7534.0" y="494.25"/> </glyph> <glyph class="state variable" id="_f4498e33-1414-42f3-9be7-37c2764cfd34"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7506.8364" y="483.0"/> </glyph> <glyph class="state variable" id="_4024b9c7-feca-4d92-9db3-f0ab8fe95503"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="7510.3306" y="523.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4343_sa4098" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <clone/> <bbox w="80.0" h="40.0" x="8257.5" y="465.0"/> <glyph class="state variable" id="_9ceb70ef-e798-47cf-b48e-8b2f5e1c9d4b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8252.5" y="471.17117"/> </glyph> <glyph class="state variable" id="_eff3f2a9-f89b-4a4f-8ab4-54bee342e0b0"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="8322.5" y="471.25"/> </glyph> <glyph class="state variable" id="_8d7cb509-ae01-42ab-b2bc-175cbc9d1a2f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8295.337" y="460.0"/> </glyph> <glyph class="state variable" id="_7bd109b7-ca8a-4fd6-b93d-318e2a38f1e9"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="8298.831" y="500.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4344_sa1018" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:TAK1 PMID:23070005 References_end </body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="5875.5" y="580.25"/> <glyph class="state variable" id="_280fae0b-b536-4922-a659-61d6a69d0bde"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5917.0684" y="575.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4345_sa3009" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytokine induced apoptosis inhibitor 1 HUGO:CIAPIN1 HGNC:28050 ENTREZ:57019 UNIPROT:Q6FI81 baculoviral IAP repeat containing 2 HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490 baculoviral IAP repeat containing 3 HUGO:BIRC3 HGNC:591 ENTREZ:330 UNIPROT:Q13489 Identifiers_end Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="cIAP*"/> <bbox w="80.0" h="40.0" x="5443.0" y="615.25"/> <glyph class="state variable" id="_57afe8bb-9c5e-4bdd-ab1f-888a48cada63"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5494.5684" y="610.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4346_sa3014" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TRADD"/> <bbox w="80.0" h="40.0" x="4760.0" y="590.0"/> </glyph> <glyph class="macromolecule" id="s4347_sa3025" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <bbox w="80.0" h="40.0" x="4860.0" y="590.0"/> </glyph> <glyph class="macromolecule" id="s4348_sa3028" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="5103.0" y="795.25"/> <glyph class="state variable" id="_fb0b6630-7629-4fe8-8c6c-ce44638e9ae9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5098.0" y="801.42114"/> </glyph> <glyph class="state variable" id="_4450270b-d4cd-47b9-b14d-2bf38e29dc61"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="5168.0" y="801.5"/> </glyph> <glyph class="state variable" id="_6f91c9b1-68f0-4b97-a773-2017c53f26ff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5140.8364" y="790.25"/> </glyph> <glyph class="state variable" id="_25f50261-8f8e-432e-8c96-a1c456496e24"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="5144.3306" y="830.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4349_sa3033" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 TGF-beta activated kinase 1/MAP3K7 binding protein 3 HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TAB*"/> <bbox w="80.0" h="40.0" x="5663.0" y="575.75"/> </glyph> <glyph class="macromolecule" id="s4350_sa3035" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <bbox w="80.0" h="40.0" x="6003.0" y="575.25"/> </glyph> <glyph class="macromolecule" id="s4351_sa3117" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DAB2 interacting protein HUGO:DAB2IP HGNC:17294 ENTREZ:153090 UNIPROT:Q5VWQ8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:AIP1 PMID:15310755 AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation References_end </body> </html> </notes> <label text="DAB2IP"/> <bbox w="80.0" h="40.0" x="4960.0" y="590.0"/> <glyph class="state variable" id="_9386cb5a-87a3-4f49-8c8d-48bd1ce9fe5f"> <state value="" variable="S604"/> <bbox w="30.0" h="10.0" x="5001.949" y="585.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4352_sa3227" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="4773.0" y="935.25"/> <glyph class="state variable" id="_c167d31b-f191-4f03-85d4-cc66acf8e367"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="4758.4927" y="930.25"/> </glyph> <glyph class="state variable" id="_c758114e-9b63-44c4-9d6f-c727660a6aa4"> <state value="" variable="S199"/> <bbox w="30.0" h="10.0" x="4814.949" y="930.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4353_sa3228" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="4950.0" y="940.0"/> <glyph class="state variable" id="_072fd739-972d-45ea-b450-0da697065b21"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="4935.4927" y="935.0"/> </glyph> <glyph class="state variable" id="_9fc912a3-4110-4edb-8f66-694578ca68aa"> <state value="P" variable="S199"/> <bbox w="35.0" h="10.0" x="4989.449" y="935.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4355_sa3246" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: riboflavin kinase HUGO:RFK HGNC:30324 ENTREZ:55312 UNIPROT:Q969G6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RFK"/> <bbox w="80.0" h="40.0" x="6103.0" y="575.75"/> </glyph> <glyph class="macromolecule" id="s4356_sa3265" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC2 HGNC:9802 ENTREZ:5880 UNIPROT:P15153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1_2*"/> <bbox w="80.0" h="40.0" x="5992.0" y="1707.5"/> </glyph> <glyph class="macromolecule" id="s4358_sa3326" compartmentRef="c15_ca15"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nucleophosmin (nucleolar phosphoprotein B23, numatrin) HUGO:NPM1 HGNC:7910 ENTREZ:4869 UNIPROT:P06748 nucleophosmin/nucleoplasmin 2 HUGO:NPM2 HGNC:7930 ENTREZ:10361 UNIPROT:Q86SE8 nucleophosmin/nucleoplasmin 3 HUGO:NPM3 HGNC:7931 ENTREZ:10360 UNIPROT:O75607 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="NPM*"/> <bbox w="80.0" h="40.0" x="3258.25" y="7958.5"/> </glyph> <glyph class="macromolecule" id="s4359_sa3327" compartmentRef="c15_ca15"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: uniprot:Q8N726 References_end </body> </html> </notes> <label text="p14ARF*"/> <bbox w="80.0" h="40.0" x="3218.25" y="7898.5"/> <glyph class="state variable" id="_c1906438-161b-4eb5-883f-9b766351ae9a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3269.8186" y="7893.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s4361_sa3329" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN2A"/> <clone/> <bbox w="70.0" h="25.0" x="7157.977" y="7301.7983"/> </glyph> <glyph class="nucleic acid feature" id="s4361_sa4654" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN2A"/> <clone/> <bbox w="70.0" h="25.0" x="4110.5" y="7261.5"/> </glyph> <glyph class="nucleic acid feature" id="s4362_sa3330" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="p14ARF*"/> <bbox w="90.0" h="25.0" x="7249.5" y="7075.5"/> <glyph class="unit of information" id="_33952903-34cd-44b7-a6ea-500b8cc4242d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7284.5" y="7070.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4363_sa3331" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual specificity phosphatase 1 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKP-1 References_end </body> </html> </notes> <label text="DUSP1"/> <bbox w="80.0" h="40.0" x="5106.0" y="2168.0"/> </glyph> <glyph class="macromolecule" id="s4364_sa3332" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual specificity phosphatase 1 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 dual specificity phosphatase 16 HUGO:DUSP16 HGNC:17909 ENTREZ:80824 UNIPROT:Q9BY84 dual specificity phosphatase 6 HUGO:DUSP6 HGNC:3072 ENTREZ:1848 UNIPROT:Q16828 dual specificity phosphatase 10 HUGO:DUSP10 HGNC:3065 ENTREZ:11221 UNIPROT:Q9Y6W6 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:MKP1 6 synonym:MKP7 synonym:MKP3 0 synonym:MKP5 References_end </body> </html> </notes> <label text="DUSP*"/> <bbox w="80.0" h="40.0" x="5396.0" y="2248.0"/> <glyph class="state variable" id="_ef7b6292-8e74-46cf-84ed-c463923a0c38"> <state value="oxidized" variable=""/> <bbox w="50.0" h="10.0" x="5411.0" y="2243.0"/> </glyph> </glyph> <glyph class="source and sink" id="s4365_sa3334" compartmentRef="c1_ca1"> <label text="s4365"/> <bbox w="30.0" h="30.0" x="5525.0" y="2255.0"/> </glyph> <glyph class="macromolecule" id="s4366_sa3335" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual specificity phosphatase 16 HUGO:DUSP16 HGNC:17909 ENTREZ:80824 UNIPROT:Q9BY84 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKP-7 References_end </body> </html> </notes> <label text="DUSP16"/> <bbox w="80.0" h="40.0" x="5106.0" y="2218.0"/> </glyph> <glyph class="macromolecule" id="s4367_sa3336" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual specificity phosphatase 6 HUGO:DUSP6 HGNC:3072 ENTREZ:1848 UNIPROT:Q16828 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKP-3 References_end </body> </html> </notes> <label text="DUSP6"/> <bbox w="80.0" h="40.0" x="5106.0" y="2268.0"/> </glyph> <glyph class="macromolecule" id="s4368_sa3337" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual specificity phosphatase 10 HUGO:DUSP10 HGNC:3065 ENTREZ:11221 UNIPROT:Q9Y6W6 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:MKP-5 References_end </body> </html> </notes> <label text="DUSP10"/> <bbox w="80.0" h="40.0" x="5106.0" y="2318.0"/> </glyph> <glyph class="macromolecule" id="s4369_sa3338" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 2, apoptosis-related cysteine peptidase HUGO:CASP2 HGNC:1503 ENTREZ:835 UNIPROT:P42575 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase2*"/> <bbox w="80.0" h="40.0" x="702.5" y="7225.0"/> <glyph class="state variable" id="_af525e12-8536-4c0a-904f-ab9cc94d0267"> <state 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x="522.5" y="7225.0"/> <glyph class="state variable" id="_4676a63b-c732-4e52-aed6-09799339eddc"> <state value="P" variable="S122"/> <bbox w="35.0" h="10.0" x="561.9493" y="7220.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4371_sa3340" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: p53-induced death domain protein HUGO:PIDD HGNC:16491 ENTREZ:55367 UNIPROT:Q9HB75 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PIDD References_end </body> </html> </notes> <label text="LRDD"/> <bbox w="80.0" h="40.0" x="435.0" y="7165.5"/> </glyph> <glyph class="macromolecule" id="s4373_sa3344" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CASP2 and RIPK1 domain containing adaptor with death domain HUGO:CRADD HGNC:2340 ENTREZ:8738 UNIPROT:P78560 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CRADD"/> <bbox w="80.0" h="40.0" x="6740.0" y="3500.0"/> </glyph> <glyph class="macromolecule" id="s4374_sa3341" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 2, apoptosis-related cysteine peptidase HUGO:CASP2 HGNC:1503 ENTREZ:835 UNIPROT:P42575 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="cleaved~Caspase2*"/> <bbox w="80.0" h="40.0" x="522.5" y="7125.0"/> <glyph class="unit of information" id="_7ca8e3fe-2254-47ad-9988-33772f873d99"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="537.5" y="7120.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4375_sa3343" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: p53-induced death domain protein HUGO:PIDD HGNC:16491 ENTREZ:55367 UNIPROT:Q9HB75 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PIDD References_end </body> </html> </notes> <label text="LRDD"/> <bbox w="80.0" h="40.0" x="6645.364" y="3501.0"/> </glyph> <glyph class="nucleic acid feature" id="s4376_sa3345" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: p53-induced death domain protein HUGO:PIDD HGNC:16491 ENTREZ:55367 UNIPROT:Q9HB75 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PIDD References_end </body> </html> </notes> <label text="LRDD"/> <bbox w="70.0" h="25.0" x="3092.5" y="7302.0"/> </glyph> <glyph class="nucleic acid feature" id="s4377_sa3346" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: p53-induced death domain protein HUGO:PIDD HGNC:16491 ENTREZ:55367 UNIPROT:Q9HB75 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PIDD References_end </body> </html> </notes> <label text="LRDD"/> <bbox w="90.0" h="25.0" x="3021.0" y="7050.75"/> <glyph class="unit of information" id="_a711c209-c84d-451b-bfe7-173cd81a3aaf"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3056.0" y="7045.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s4383_sa3348" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1 HGNC:1722 ENTREZ:983 UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:CDC2 References_end </body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="2910.7368" y="3097.9336"/> </glyph> <glyph class="complex" id="s4384_csa138" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK1:CyclinB1* Identifiers_end </body> </html> </notes> <label text="CCNB1:CDC2"/> <bbox w="100.0" h="120.0" x="6916.666" y="3641.7236"/> <glyph class="macromolecule" id="s4385_sa1432"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin B1 HUGO:CCNB1 HGNC:1579 ENTREZ:891 UNIPROT:P14635 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="CyclinB1*"/> <bbox w="80.0" h="40.0" x="6927.666" y="3654.7236"/> </glyph> <glyph class="macromolecule" id="s2521_sa1764"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1 HGNC:1722 ENTREZ:983 UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:CDC2 References_end </body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="6929.166" y="3698.582"/> </glyph> </glyph> <glyph class="complex" id="s4386_csa358" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BCL2-XL* Identifiers_end </body> </html> </notes> <label text="BAX:BCL2L1"/> <bbox w="100.0" h="130.0" x="4160.0" y="5685.0"/> <glyph class="macromolecule" id="s4388_sa3349"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="4170.93" y="5743.152"/> </glyph> <glyph class="macromolecule" id="s4387_sa3350"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4171.228" y="5699.152"/> <glyph class="state variable" id="_b7a3abd7-1ad6-47a3-932e-71c621da9da2"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4169.805" y="5694.152"/> </glyph> <glyph class="state variable" id="_400d3b0d-8d76-4f9d-82f0-a1870347fd81"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4214.8125" y="5694.152"/> </glyph> <glyph class="state variable" id="_7b34b95f-2716-4cbb-9191-583f02c9aae8"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4217.5493" y="5734.152"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s4391_csa359" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2:p53* Identifiers_end </body> </html> </notes> <label text="BCL2:TP53"/> <bbox w="110.0" h="130.0" x="5085.0" y="4585.0"/> <glyph class="macromolecule" id="s4389_sa3352"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="5104.939" y="4640.342"/> <glyph class="state variable" id="_8e618eb3-a7d5-4ab7-aaba-511b4bafe89d"> <state value="" variable="S15"/> <bbox w="25.0" h="10.0" x="5149.388" y="4635.342"/> </glyph> </glyph> <glyph class="macromolecule" id="s4392_sa3353"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5101.682" y="4596.487"/> <glyph class="state variable" id="_5052741c-d598-4c7c-96c1-2670805af533"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5120.114" y="4591.487"/> </glyph> <glyph class="state variable" id="_16723bd1-0390-45fa-b1d3-a1c073a540a5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5153.2505" y="4591.487"/> </glyph> <glyph class="state variable" id="_274f74c2-a3bf-45ad-acb0-8214355833bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5096.682" y="4611.487"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4394_sa3354" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5350.0" y="4020.0"/> <glyph class="state variable" id="_bb60e31e-02f5-4806-b287-526c00e0b7a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5368.4316" y="4015.0"/> </glyph> <glyph class="state variable" id="_d47b071f-0503-42b3-966a-d047e5ca7fea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5401.5684" y="4015.0"/> </glyph> <glyph class="state variable" id="_fc047208-7981-4e15-bd26-57becc1b6afe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5345.0" y="4035.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4395_sa3355" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5230.0" y="4885.0"/> <glyph class="state variable" id="_09299c24-1f36-48e5-902f-b79baa4faf24"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5248.4316" y="4880.0"/> </glyph> <glyph class="state variable" id="_17bc9e3b-0a08-47dd-bb36-c02ca12ac150"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="5279.0684" y="4880.0"/> </glyph> <glyph class="state variable" id="_6a3cf755-4f40-40da-93b4-5b6a64fd3271"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5225.0" y="4900.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4397_sa3358" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase C, alpha HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="PRKCA"/> <bbox w="80.0" h="40.0" x="5150.0" y="3470.0"/> </glyph> <glyph class="macromolecule" id="s4398_sa3359" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear receptor subfamily 4, group A, member 1 HUGO:NR4A1 HGNC:7980 ENTREZ:3164 UNIPROT:P22736 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:NUR77/TR3 References_end </body> </html> </notes> <label text="NR4A1"/> <bbox w="80.0" h="40.0" x="4780.0" y="6420.0"/> </glyph> <glyph class="complex" id="s4400_csa360" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2:NR4A1 Identifiers_end </body> </html> </notes> <label text="BCL2:Nur77"/> <bbox w="100.0" h="120.0" x="5065.0" y="5110.0"/> <glyph class="macromolecule" id="s4399_sa3360"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear receptor subfamily 4, group A, member 1 HUGO:NR4A1 HGNC:7980 ENTREZ:3164 UNIPROT:P22736 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:NUR77/TR3 References_end </body> </html> </notes> <label text="NR4A1"/> <bbox w="80.0" h="40.0" x="5073.7583" y="5167.0137"/> </glyph> <glyph class="macromolecule" id="s4401_sa3361"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="5076.7583" y="5123.0137"/> <glyph class="state variable" id="_2c1451f6-51a9-4fde-8e6c-0f488eb24f0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5095.19" y="5118.0137"/> </glyph> <glyph class="state variable" id="_e1ab8993-8291-4bb1-9b4e-5874d55400a9"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="5125.8267" y="5118.0137"/> </glyph> <glyph class="state variable" id="_c02cbeff-7839-477b-bf46-89272fdae7b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5071.7583" y="5138.0137"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s4403_csa361" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:p53* Identifiers_end </body> </html> </notes> <label text="BCL2L1:TP53"/> <bbox w="100.0" h="120.0" x="5100.0" y="4340.0"/> <glyph class="macromolecule" id="s4402_sa3363"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="5109.7583" y="4393.0137"/> <glyph class="state variable" id="_6bff3374-df32-44db-af0d-b63fade5357c"> <state value="" variable="S15"/> <bbox w="25.0" h="10.0" x="5154.2075" y="4388.0137"/> </glyph> </glyph> <glyph class="macromolecule" id="s4404_sa3364"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="5109.7583" y="4349.0137"/> </glyph> </glyph> <glyph class="macromolecule" id="s4405_sa3365" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 HUGO:SLC25A4 HGNC:10990 ENTREZ:291 UNIPROT:P12235 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 HUGO:SLC25A5 HGNC:10991 ENTREZ:292 UNIPROT:P05141 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 HUGO:SLC25A6 HGNC:10992 ENTREZ:293 UNIPROT:P12236 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="ANT*"/> <bbox w="80.0" h="40.0" x="3260.0" y="5050.0"/> </glyph> <glyph class="complex" id="s4406_csa362" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAK1:MCL1 Identifiers_end </body> </html> </notes> <label text="BAK1:MCL1"/> <bbox w="100.0" h="130.0" x="5110.0" y="5625.0"/> <glyph class="macromolecule" id="s4408_sa3368"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="5121.0" y="5682.0"/> <glyph class="state variable" id="_a1d7b146-8ef2-406d-a018-6bf534cbee06"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5175.9946" y="5677.0"/> </glyph> <glyph class="state variable" id="_47bc6034-8dd7-4396-a7ad-f12f86c090b3"> <state value="?" variable="S159"/> <bbox w="35.0" h="10.0" x="5122.1646" y="5677.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4407_sa3369"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="5121.0" y="5636.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s4409_sa3371" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:3942 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MTOR"/> <bbox w="90.0" h="25.0" x="7692.5" y="7120.5"/> <glyph class="unit of information" id="_81037f43-4352-4e25-9b17-05f95c08c3d6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7727.5" y="7115.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4410_sa3372" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-cysteine ligase, catalytic subunit HUGO:GCLC HGNC:4311 ENTREZ:2729 UNIPROT:P48506 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS Maps_Modules_end </body> </html> </notes> <label text="cleaved~GCLC*"/> <bbox w="80.0" h="40.0" x="8590.0" y="425.0"/> <glyph class="unit of information" id="_9524b6a2-f774-4556-8a22-34abd8cc21d1"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8605.0" y="420.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4411_sa2039" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-ammonia ligase HUGO:GLUL HGNC:4341 ENTREZ:2752 UNIPROT:P15104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUL"/> <bbox w="80.0" h="40.0" x="1390.0" y="3470.0"/> <glyph class="state variable" id="_dfd95a65-9312-4651-a249-3377127e378a"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="1439.0686" y="3465.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4412_sa2019" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate dehydrogenase 1 HUGO:GLUD1 HGNC:4335 ENTREZ:2746 UNIPROT:P00367 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUD1"/> <bbox w="80.0" h="40.0" x="442.0" y="5996.0"/> <glyph class="state variable" id="_62a50272-8aad-4670-8dcc-f9a0aedc6a5a"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="491.06854" y="5991.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4413_sa2704" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC HGNC:9413 ENTREZ:5591 UNIPROT:P78527 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:DNAPK References_end </body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="612.5" y="7105.0"/> <glyph class="state variable" id="_9068208f-4ec6-4cf6-adf1-16a8808096fd"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="661.56854" y="7100.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4415_sa3374" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucose-6-phosphate isomerase HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GPI"/> <bbox w="86.0" h="46.0" x="947.0" y="737.0"/> <glyph class="unit of information" id="_2e11215f-ca3f-4e79-a2ec-341f1ec432b7"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="980.0" y="732.0"/> </glyph> <glyph class="state variable" id="_84e75953-52d6-4a7e-98e4-b5dbd6cc3eb8"> <state value="" variable="S185"/> <bbox w="30.0" h="10.0" x="993.22046" y="732.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4416_sa3375" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucose-6-phosphate isomerase HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GPI"/> <bbox w="86.0" h="46.0" x="947.0" y="577.0"/> <glyph class="unit of information" id="_70e67a60-96f3-4cd6-95fd-a09bdc12f46f"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="980.0" y="572.0"/> </glyph> <glyph class="state variable" id="_eeaeb9f9-ee44-4e10-b142-d1b3f2311e28"> <state value="P" variable="S185"/> <bbox w="35.0" h="10.0" x="990.72046" y="572.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4417_sa3376" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphofructokinase, platelet HUGO:PFKP HGNC:8878 ENTREZ:5214 UNIPROT:Q01813 phosphofructokinase, liver HUGO:PFKL HGNC:8876 ENTREZ:5211 UNIPROT:P17858 phosphofructokinase, muscle HUGO:PFKM HGNC:8877 ENTREZ:5213 UNIPROT:P08237 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFK*"/> <bbox w="86.0" h="46.0" x="1396.0" y="1091.1896"/> <glyph class="unit of information" id="_d12a1045-0456-4cf0-9ec8-4b3db1ac523f"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="1429.0" y="1086.1896"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4418_sa3377" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aldolase A, fructose-bisphosphate HUGO:ALDOA HGNC:414 ENTREZ:226 UNIPROT:P04075 aldolase B, fructose-bisphosphate HUGO:ALDOB HGNC:417 ENTREZ:229 UNIPROT:P05062 aldolase C, fructose-bisphosphate HUGO:ALDOC HGNC:418 ENTREZ:230 UNIPROT:P09972 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: ÒR References_end </body> </html> </notes> <label text="ALDO*"/> <bbox w="86.0" h="46.0" x="947.0" y="1377.0"/> <glyph class="unit of information" id="_1db2fb90-c7f3-4fd4-871a-ff5a2c455514"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="980.0" y="1372.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4419_sa3378" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glyceraldehyde-3-phosphate dehydrogenase HUGO:GAPDH HGNC:4141 ENTREZ:2597 UNIPROT:P04406 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic HUGO:GAPDHS HGNC:24864 ENTREZ:26330 UNIPROT:O14556 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="GAPDH*"/> <bbox w="86.0" h="46.0" x="1249.5" y="1472.0"/> <glyph class="unit of information" id="_86e98080-0d7c-48a9-9c3d-eb3f6c1a87ed"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="1282.5" y="1467.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4420_sa3379" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: triosephosphate isomerase 1 HUGO:TPI1 HGNC:12009 ENTREZ:7167 UNIPROT:P60174 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23988223 References_end </body> </html> </notes> <label text="TPI1"/> <bbox w="86.0" h="46.0" x="1269.5" y="1382.0"/> <glyph class="unit of information" id="_d935d2b5-58e6-4268-8484-c103b4e6c5d6"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1302.5" y="1377.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4421_sa3380" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglycerate mutase 1 (brain) HUGO:PGAM1 HGNC:8888 ENTREZ:5223 UNIPROT:P18669 phosphoglycerate mutase 2 (muscle) HUGO:PGAM2 HGNC:8889 ENTREZ:5224 UNIPROT:P15259 phosphoglycerate mutase family member 4 HUGO:PGAM4 HGNC:21731 ENTREZ:441531 UNIPROT:Q8N0Y7 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PGAM*"/> <bbox w="86.0" h="46.0" x="1184.7163" y="1840.8988"/> <glyph class="unit of information" id="_78ea6c2d-a76d-414d-98e6-7647a443cf10"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1217.7163" y="1835.8988"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4422_sa3381" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lactate dehydrogenase A HUGO:LDHA HGNC:6535 ENTREZ:3939 UNIPROT:P00338 lactate dehydrogenase B HUGO:LDHB HGNC:6541 ENTREZ:3945 UNIPROT:P07195 lactate dehydrogenase C HUGO:LDHC HGNC:6544 ENTREZ:3948 UNIPROT:P07864 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="LDH*"/> <bbox w="86.0" h="46.0" x="1255.7163" y="2380.899"/> <glyph class="unit of information" id="_bd498075-cfef-4b58-a9f8-91393c06d75d"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="1288.7163" y="2375.899"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4423_sa3382" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: uroporphyrinogen decarboxylase HUGO:UROD HGNC:12591 ENTREZ:7389 UNIPROT:P06132 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="UROD"/> <bbox w="86.0" h="46.0" x="277.0" y="4127.0"/> <glyph class="unit of information" id="_2388b697-8dcd-4996-87a0-6ed51da8b93e"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="310.0" y="4122.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4424_sa3383" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 HUGO:PFKFB1 HGNC:8872 ENTREZ:5207 UNIPROT:P16118 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 HUGO:PFKFB2 HGNC:8873 ENTREZ:5208 UNIPROT:O60825 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 HUGO:PFKFB3 HGNC:8874 ENTREZ:5209 UNIPROT:Q16875 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 HUGO:PFKFB4 HGNC:8875 ENTREZ:5210 UNIPROT:Q16877 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PFKFB*"/> <bbox w="86.0" h="46.0" x="1207.0" y="727.0"/> <glyph class="unit of information" id="_8075b930-0445-4c15-9668-561edd98e4ac"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1240.0" y="722.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4425_sa3384" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glucose-6-phosphate dehydrogenase HUGO:G6PD HGNC:4057 ENTREZ:2539 UNIPROT:P11413 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="G6PD"/> <bbox w="86.0" h="46.0" x="587.0" y="897.0"/> <glyph class="unit of information" id="_a303fa50-59b3-4a2f-a110-b0ac47c5499b"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="620.0" y="892.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4426_sa3385" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphogluconate dehydrogenase HUGO:PGD HGNC:8891 ENTREZ:5226 UNIPROT:P52209 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PGD"/> <bbox w="86.0" h="46.0" x="759.5" y="1182.0"/> <glyph class="unit of information" id="_e550c91a-a6d1-4b8a-8ea9-681e4e153f22"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="792.5" y="1177.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4427_sa3386" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATP citrate lyase HUGO:ACLY HGNC:115 ENTREZ:47 UNIPROT:P53396 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="ACLY"/> <bbox w="86.0" h="46.0" x="696.24347" y="2795.125"/> <glyph class="unit of information" id="_334eba2b-29a0-41be-85ce-fca0a6c3f639"> <label text="N:4"/> <bbox w="20.0" h="10.0" x="729.24347" y="2790.125"/> </glyph> <glyph class="state variable" id="_c94631ed-d85e-4cbe-a4e3-96318635fc91"> <state value="*" variable="S454"/> <bbox w="35.0" h="10.0" x="739.9639" y="2790.125"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4428_sa3387" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate-ammonia ligase HUGO:GLUL HGNC:4341 ENTREZ:2752 UNIPROT:P15104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUL"/> <bbox w="86.0" h="46.0" x="1087.0" y="3487.0"/> <glyph class="unit of information" id="_a8526231-e27e-4140-9722-2568f35ac6bf"> <label text="N:8"/> <bbox w="20.0" h="10.0" x="1120.0" y="3482.0"/> </glyph> <glyph class="state variable" id="_02e465d0-036c-4b2f-a4c5-4c0277b97520"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="1140.3112" y="3482.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4429_sa3388" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamic-pyruvate transaminase (alanine aminotransferase) HUGO:GPT HGNC:4552 ENTREZ:2875 UNIPROT:P24298 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GPT*"/> <bbox w="86.0" h="46.0" x="967.0" y="6067.0"/> <glyph class="unit of information" id="_4ac5b719-e648-422f-8a4c-35fa85eece31"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1000.0" y="6062.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4430_sa3389" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate dehydrogenase 1 HUGO:GLUD1 HGNC:4335 ENTREZ:2746 UNIPROT:P00367 glutamate dehydrogenase 2 HUGO:GLUD2 HGNC:4336 ENTREZ:2747 UNIPROT:P49448 Identifiers_end Maps_Modules_begin: MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUD*"/> <bbox w="86.0" h="46.0" x="692.0" y="6033.0"/> <glyph class="unit of information" id="_836dc634-398c-4977-9cdf-174832206e31"> <label text="N:6"/> <bbox w="20.0" h="10.0" x="725.0" y="6028.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4431_sa3390" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: malate dehydrogenase 1, NAD (soluble) HUGO:MDH1 HGNC:6970 ENTREZ:4190 UNIPROT:P40925 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MDH1"/> <bbox w="86.0" h="46.0" x="1216.3606" y="5445.0376"/> <glyph class="unit of information" id="_113397e5-e302-4493-928d-7a417b218987"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1249.3606" y="5440.0376"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4432_sa3391" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:FERROPTOSIS Maps_Modules_end References_begin: from Uniprot:"homodimer, by similarity" References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: citrate synthase HUGO:CS HGNC:2422 ENTREZ:1431 UNIPROT:O75390 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:FERROPTOSIS Maps_Modules_end References_begin: synonym:citrate synthase References_end </body> </html> </notes> <label text="CS"/> <bbox w="86.0" h="46.0" x="1461.25" y="5652.0"/> <glyph class="unit of information" id="_de7dde7e-2e0b-4236-8700-919795894407"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1494.25" y="5647.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4433_sa3392" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferrochelatase HUGO:FECH HGNC:3647 ENTREZ:2235 UNIPROT:P22830 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="FECH"/> <bbox w="86.0" h="46.0" x="1491.25" y="4184.0"/> <glyph class="state variable" id="_c909926b-c731-48f4-8528-35cd8db369ee"> <state value="[2FE-2S]" variable=""/> <bbox w="50.0" h="10.0" x="1509.25" y="4179.0"/> </glyph> <glyph class="unit of information" id="_d50c240d-cae0-4854-9ca4-03b5caae485b"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1524.25" y="4225.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4434_sa3393" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: vascular endothelial growth factor A HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692 Identifiers_end </body> </html> </notes> <label text="VEGFA"/> <bbox w="86.0" h="46.0" x="5897.0" y="8167.0"/> <glyph class="unit of information" id="_5279de3d-3d63-49eb-b7e2-a46856a09695"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5930.0" y="8162.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s4446_sa3410" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30413 Identifiers_end </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="1379.25" y="3995.5"/> </glyph> <glyph class="macromolecule" id="s4451_sa2206" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: aminolevulinate dehydratase HUGO:ALAD HGNC:395 ENTREZ:210 UNIPROT:P13716 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="ALAD"/> <bbox w="80.0" h="40.0" x="190.0" y="3540.0"/> </glyph> <glyph class="complex" id="s4457_csa12" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IDH2:Mg2+ Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH2"/> <bbox w="102.0" h="90.0" x="1015.75" y="5936.0"/> <glyph class="macromolecule multimer" id="s4455_sa3418"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: isocitrate dehydrogenase 2 (NADP+), mitochondrial HUGO:IDH2 HGNC:5383 ENTREZ:3418 UNIPROT:P48735 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH2"/> <bbox w="86.0" h="46.0" x="1021.75" y="5959.0"/> <glyph class="unit of information" id="_463ee0a7-0edc-4480-b5be-707a67465bac"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1054.75" y="5954.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s4456_sa3419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:18420 </body> </html> </notes> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1082.2631" y="5940.75"/> </glyph> </glyph> <glyph class="complex" id="s4460_csa11" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IDH3A:IDH3B:IDH3C:Mg2+ Identifiers_end </body> </html> </notes> <label text="IDH3"/> <bbox w="102.0" h="158.0" x="1135.75" y="5892.0"/> <glyph class="macromolecule" id="s549_sa167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) beta HUGO:IDH3B HGNC:5385 ENTREZ:3420 UNIPROT:O43837 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3B"/> <bbox w="80.0" h="40.0" x="1144.75" y="5943.0"/> </glyph> <glyph class="macromolecule" id="s7588_sa168"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) gamma HUGO:IDH3G HGNC:5386 ENTREZ:3421 UNIPROT:P51553 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3C"/> <bbox w="80.0" h="40.0" x="1143.75" y="5986.0"/> </glyph> <glyph class="macromolecule multimer" id="s4458_sa3420"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: isocitrate dehydrogenase 3 (NAD+) alpha HUGO:IDH3A HGNC:5384 ENTREZ:3419 UNIPROT:P50213 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="IDH3A"/> <bbox w="86.0" h="46.0" x="1143.375" y="5896.125"/> <glyph class="unit of information" id="_66e05d9e-de60-4732-b2a3-984ae348ce16"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1176.375" y="5891.125"/> </glyph> </glyph> <glyph class="simple chemical" id="s8326_sa5534"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:18420 </body> </html> </notes> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1207.0" y="5898.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4461_sa3422" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase complex, component X HUGO:PDHX HGNC:21350 ENTREZ:8050 UNIPROT:O00330 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PDHX"/> <bbox w="80.0" h="40.0" x="1810.0" y="6010.0"/> </glyph> <glyph class="macromolecule" id="s4462_sa3423" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PDHA2"/> <bbox w="80.0" h="40.0" x="2560.0" y="5976.0"/> </glyph> <glyph class="macromolecule" id="s4465_sa3424" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:pyruvate dehydrogenase (lipoamide) alpha 1 References_end </body> </html> </notes> <label text="PDHA1"/> <bbox w="80.0" h="40.0" x="2560.0" y="6020.0"/> </glyph> <glyph class="macromolecule" id="s4466_sa3425" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="2430.0" y="6000.0"/> <glyph class="state variable" id="_c6ea2ad9-a788-436d-8ad8-adb7d2a9a902"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2481.5686" y="5995.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4467_sa3426" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pyruvate dehydrogenase (lipoamide) beta HUGO:PDHB HGNC:8808 ENTREZ:5162 UNIPROT:P11177 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PDHB"/> <bbox w="80.0" h="40.0" x="2429.0" y="6045.0"/> </glyph> <glyph class="complex" id="s4470_csa363" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PDHA*:PDHB Identifiers_end </body> </html> </notes> <label text="PDH"/> <bbox w="100.0" h="120.0" x="2295.0" y="5985.0"/> <glyph class="macromolecule multimer" id="s4468_sa3427"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="86.0" h="46.0" x="2302.0" y="5995.0"/> <glyph class="unit of information" id="_7934b3ba-0980-4fa1-983c-b4f68468943b"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="2335.0" y="5990.0"/> </glyph> <glyph class="state variable" id="_192b6042-3069-4cfc-9627-9b735e1468f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2357.8113" y="5990.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4469_sa3428"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) beta HUGO:PDHB HGNC:8808 ENTREZ:5162 UNIPROT:P11177 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PDHB"/> <bbox w="86.0" h="46.0" x="2301.0" y="6040.0"/> <glyph class="unit of information" id="_2438bcbe-297f-405f-bfab-6a083d5a5cd4"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="2334.0" y="6035.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4471_sa3429" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: E2 in this complex References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="1810.0" y="6070.0"/> <glyph class="state variable" id="_ba84cad2-bff6-4147-8ae3-60d883b581e3"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="1820.0" y="6065.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4472_sa3430" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of growth family, member 4 HUGO:ING4 HGNC:19423 ENTREZ:51147 UNIPROT:Q9UNL4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="ING4"/> <bbox w="80.0" h="40.0" x="7367.5" y="5769.25"/> </glyph> <glyph class="complex" id="s4474_csa364" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ING4:PHD* Identifiers_end </body> </html> </notes> <label text="ING4:PHD"/> <bbox w="100.0" h="120.0" x="7217.5" y="5789.25"/> <glyph class="macromolecule" id="s4476_sa3432"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of growth family, member 4 HUGO:ING4 HGNC:19423 ENTREZ:51147 UNIPROT:Q9UNL4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="ING4"/> <bbox w="80.0" h="40.0" x="7228.5" y="5800.5"/> </glyph> <glyph class="macromolecule" id="s4475_sa3433"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: egl nine homolog 1 (C. elegans) HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9 egl nine homolog 2 (C. elegans) HUGO:EGLN2 HGNC:14660 ENTREZ:112398 UNIPROT:Q96KS0 egl nine homolog 3 (C. elegans) HUGO:EGLN3 HGNC:14661 ENTREZ:112399 UNIPROT:Q9H6Z9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PHD*"/> <bbox w="80.0" h="40.0" x="7228.5" y="5844.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s4478_sa3435" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peroxiredoxin 2 HUGO:PRDX2 HGNC:9353 ENTREZ:7001 UNIPROT:P32119 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="PRDX2"/> <bbox w="90.0" h="25.0" x="5903.5" y="7057.5"/> <glyph class="unit of information" id="_beebeb8a-da9c-464f-b6da-2652778ee437"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5938.5" y="7052.5"/> </glyph> </glyph> <glyph class="source and sink" id="s4479_sa3436" compartmentRef="c1_ca1"> <label text="s4479"/> <bbox w="30.0" h="30.0" x="4954.8394" y="6559.2695"/> </glyph> <glyph class="macromolecule" id="s4480_sa3437" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="4929.8394" y="6504.2695"/> <glyph class="state 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Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CTBP1"/> <bbox w="80.0" h="40.0" x="3772.5" y="7575.0"/> </glyph> <glyph class="macromolecule" id="s4494_sa3451" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label 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<head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="602.5" y="7595.0"/> <glyph class="state variable" id="_a0dd0414-d9ad-4861-a08c-b73b2bc8915a"> <state value="*" variable="T699"/> <bbox w="35.0" h="10.0" x="608.59503" y="7590.0"/> </glyph> <glyph class="state variable" id="_4a4e41e9-b7f2-4ecf-8197-530679d71746"> <state value="*" variable="T752"/> <bbox w="35.0" h="10.0" x="641.9493" y="7590.0"/> </glyph> <glyph class="state variable" id="_234cb766-7f09-45c6-b96f-c6fb9e64fdc5"> <state value="P" variable="Nter-SDT-motifs"/> <bbox w="80.0" h="10.0" x="585.00104" y="7630.0"/> </glyph> <glyph class="state variable" 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<glyph class="state variable" id="_27b3055f-77c3-429b-9779-4578607693ca"> <state value="" variable="T752"/> <bbox w="30.0" h="10.0" x="814.4493" y="7650.0"/> </glyph> <glyph class="state variable" id="_8809329b-41ce-4de9-a5d2-5f6ebb3b02de"> <state value="P" variable="Nter-SDT-motifs"/> <bbox w="80.0" h="10.0" x="755.00104" y="7690.0"/> </glyph> <glyph class="state variable" id="_9df54e8e-034e-4881-8381-e23acd79e1a1"> <state value="" variable="T719"/> <bbox w="30.0" h="10.0" x="797.53186" y="7650.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4497_sa3454" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nibrin HUGO:NBN HGNC:7652 ENTREZ:4683 UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:NBS1 References_end </body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="612.5" y="7655.0"/> </glyph> <glyph class="macromolecule" id="s4498_sa3455" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A HGNC:7230 ENTREZ:4361 UNIPROT:P49959 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:MRE11 References_end </body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="610.0" y="7710.0"/> </glyph> <glyph class="macromolecule" id="s4499_sa3456" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50 HGNC:9816 ENTREZ:10111 UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="612.5" y="7765.0"/> </glyph> <glyph class="macromolecule" id="s4500_sa3457" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="770.0" y="7990.0"/> <glyph class="state variable" id="_6850db40-5c1c-4911-8ad4-2b77191093d3"> <state value="" variable="T699"/> <bbox w="30.0" h="10.0" x="778.59503" y="7985.0"/> </glyph> <glyph class="state variable" id="_372b50f3-599c-4e87-a4bc-4c1d7b627b16"> <state value="" variable="T752"/> <bbox w="30.0" h="10.0" x="811.9493" y="7985.0"/> </glyph> <glyph class="state variable" id="_4e4eafa1-b631-4bbf-91df-ae4bf4d45584"> <state value="" variable="Nter-SDT-motifs"/> <bbox w="80.0" h="10.0" x="752.50104" y="8025.0"/> </glyph> <glyph class="state variable" id="_1cd6d876-0ad3-4057-91b4-906475046651"> <state value="" variable="T719"/> <bbox w="30.0" h="10.0" x="795.03186" y="7985.0"/> </glyph> </glyph> <glyph class="complex" id="s4501_csa366" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MRE11*:NBS1*:RAD50 Identifiers_end </body> </html> </notes> <label text="MRN complex"/> <bbox w="100.0" h="156.0" x="445.0" y="7707.0"/> <glyph class="macromolecule" id="s3681_sa3462"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50 HGNC:9816 ENTREZ:10111 UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="456.1406" y="7803.396"/> </glyph> <glyph class="macromolecule" id="s3682_sa3463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A HGNC:7230 ENTREZ:4361 UNIPROT:P49959 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:MRE11 References_end </body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="455.1406" y="7760.396"/> </glyph> <glyph class="macromolecule" id="s3683_sa3464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nibrin HUGO:NBN HGNC:7652 ENTREZ:4683 UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:NBS1 References_end </body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="456.1406" y="7716.396"/> </glyph> </glyph> <glyph class="macromolecule" id="s4504_sa3458" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="769.34076" y="7918.6567"/> <glyph class="state variable" id="_c4cc425c-e7d5-4d73-9ab0-42804f3455a3"> <state value="" variable="T699"/> 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Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50 HGNC:9816 ENTREZ:10111 UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="305.0" y="7802.0"/> </glyph> <glyph class="macromolecule" id="s4506_sa3460" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A HGNC:7230 ENTREZ:4361 UNIPROT:P49959 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:MRE11 References_end </body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="304.0" y="7759.0"/> </glyph> <glyph class="macromolecule" id="s4507_sa3461" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nibrin HUGO:NBN HGNC:7652 ENTREZ:4683 UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:NBS1 References_end </body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="302.5" y="7655.0"/> </glyph> <glyph class="complex" id="s4510_csa367" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK_beta_* Identifiers_end References_begin: casein kinase 2 References_end </body> </html> </notes> <label text="CSNK2"/> <bbox w="176.0" h="110.0" x="542.0" y="7915.0"/> <glyph class="macromolecule" id="s4511_sa3465"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: casein kinase 2, alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="551.0" y="7922.0"/> </glyph> <glyph class="macromolecule" id="s4512_sa3466"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: casein kinase 2, alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="633.0" y="7923.0"/> </glyph> <glyph class="macromolecule" id="s4513_sa3467"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chemokine (C-C motif) ligand 19 HUGO:CCL19 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CKβ*"/> <bbox w="80.0" h="40.0" x="551.0" y="7964.0"/> </glyph> <glyph class="macromolecule" id="s4513_sa3468"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chemokine (C-C motif) ligand 19 HUGO:CCL19 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:GLUCOSE_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CKβ*"/> <bbox w="80.0" h="40.0" x="632.5" y="7965.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s4516_sa3472" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM HGNC:795 ENTREZ:472 UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATM"/> <bbox w="86.0" h="46.0" x="982.0" y="7792.0"/> <glyph class="unit of information" id="_c5d04555-bd73-488f-bb93-d2773c581ae9"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1015.0" y="7787.0"/> </glyph> <glyph class="state variable" id="_c71b1d65-5955-42d3-b130-a961ce89a04e"> <state value="" variable="K3016"/> <bbox w="35.0" h="10.0" x="989.8646" y="7787.0"/> </glyph> <glyph class="state variable" id="_a2997670-4742-400b-adec-a24e5236cce9"> <state value="" variable="S1981"/> <bbox w="35.0" h="10.0" x="1025.3112" y="7787.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4517_sa3473" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM HGNC:795 ENTREZ:472 UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="985.06165" y="7673.097"/> <glyph class="state variable" id="_db2278f3-527c-406c-9dd5-dc3f591ccf75"> <state value="Ac" variable="K3016"/> <bbox w="45.0" h="10.0" x="986.1567" y="7668.097"/> </glyph> <glyph class="state 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References_end </body> </html> </notes> <label text="PP2A*"/> <bbox w="80.0" h="40.0" x="1220.0" y="7900.0"/> </glyph> <glyph class="macromolecule multimer" id="s4520_sa3471" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM HGNC:795 ENTREZ:472 UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATM"/> <bbox w="86.0" h="46.0" x="977.0" y="7917.0"/> <glyph class="unit of information" 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ENTREZ:3014 UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:H2AX References_end </body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="432.5" y="7435.0"/> <glyph class="state variable" id="_9fa2eb84-d978-4590-932d-597b4c586718"> <state value="P" variable="Y142"/> <bbox w="35.0" h="10.0" x="438.59503" y="7430.0"/> </glyph> <glyph class="state variable" id="_6a65e4c1-4fec-4799-90a4-bde9dddb58d8"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="474.44928" y="7430.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4522_sa3478" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: H2A histone family, member X HUGO:H2AFX HGNC:4739 ENTREZ:3014 UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:H2AX References_end </body> </html> </notes> <label text="H2AFX"/> <clone/> <bbox w="80.0" h="40.0" x="10412.266" y="7285.0"/> <glyph class="state variable" id="_531ac160-5b9c-47bb-82d1-50b44728258a"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="10420.86" y="7280.0"/> </glyph> <glyph class="state variable" id="_9703e788-6630-4566-b0ea-57df77437a7d"> <state value="" variable="S139"/> <bbox w="30.0" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: H2A histone family, member X HUGO:H2AFX HGNC:4739 ENTREZ:3014 UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:H2AX References_end </body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="432.5" y="7285.0"/> <glyph class="state variable" id="_87f498c3-a997-4d25-b1b6-4f104f7e7f9b"> <state value="P" variable="Y142"/> <bbox w="35.0" h="10.0" x="438.59503" y="7280.0"/> </glyph> <glyph class="state variable" id="_6b0314ab-126d-4709-ac37-eba75f3d9cf5"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="471.94928" y="7280.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4526_sa3482" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 HUGO:SMARCA5 HGNC:11101 ENTREZ:8467 UNIPROT:O60264 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:SNF2H References_end </body> </html> </notes> <label text="SMARCA5"/> <bbox w="80.0" h="40.0" x="192.5" y="7495.0"/> </glyph> <glyph class="macromolecule" id="s4527_sa3483" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: bromodomain adjacent to zinc finger domain, 1B HUGO:BAZ1B HGNC:961 ENTREZ:9031 UNIPROT:Q9UIG0 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:WSTF References_end </body> </html> </notes> <label text="BAZ1B"/> <bbox w="80.0" h="40.0" x="193.5" y="7448.0"/> </glyph> <glyph class="macromolecule" id="s4528_sa3485" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eyes absent homolog 3 (Drosophila) HUGO:EYA3 HGNC:3521 ENTREZ:2140 UNIPROT:Q99504 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="EYA3"/> <bbox w="80.0" h="40.0" x="602.5" y="7355.0"/> </glyph> <glyph class="macromolecule" id="s4529_sa3486" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eyes absent homolog 1 (Drosophila) HUGO:EYA1 HGNC:3519 ENTREZ:2138 UNIPROT:Q99502 eyes absent homolog 3 (Drosophila) HUGO:EYA3 HGNC:3521 ENTREZ:2140 UNIPROT:Q99504 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="EYA*"/> <bbox w="80.0" h="40.0" x="495.0" y="7355.0"/> </glyph> <glyph class="macromolecule" id="s4536_sa704" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="6300.0" y="6920.0"/> <glyph class="state variable" id="_2c8b22a9-4fc6-4841-9398-a8a865951ea1"> <state value="" variable="S15"/> <bbox w="25.0" h="10.0" x="6344.449" y="6915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4537_sa3492" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="3655.0" y="7505.0"/> <glyph class="state variable" id="_4e8670a0-5164-43b6-a171-113d85de56d4"> <state value="" variable="S15"/> <bbox w="25.0" h="10.0" x="3699.4492" y="7500.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4539_sa3498" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: histone cluster 2, H2ac HUGO:HIST2H2AC HGNC:4738 ENTREZ:8338 UNIPROT:Q16777 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="H2A*"/> <bbox w="80.0" h="40.0" x="1420.0" y="7510.0"/> </glyph> <glyph class="macromolecule" id="s4540_sa3502" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="1122.5" y="7685.0"/> </glyph> <glyph class="macromolecule" id="s4541_sa3505" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="932.6406" y="7410.896"/> </glyph> <glyph class="macromolecule" id="s4542_sa3506" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin interaction motif containing 1 HUGO:UIMC1 HGNC:30298 ENTREZ:51720 UNIPROT:Q96RL1 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:RAP80 References_end </body> </html> </notes> <label text="UIMC1"/> <clone/> <bbox w="80.0" h="40.0" x="1312.5" y="7625.0"/> </glyph> <glyph class="macromolecule" id="s4542_sa3515" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin interaction motif containing 1 HUGO:UIMC1 HGNC:30298 ENTREZ:51720 UNIPROT:Q96RL1 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:RAP80 References_end </body> </html> </notes> <label text="UIMC1"/> <clone/> <bbox w="80.0" h="40.0" x="931.5" y="7499.0"/> </glyph> <glyph class="macromolecule" id="s4543_sa3511" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BRCA1 associated RING domain 1 HUGO:BARD1 HGNC:952 ENTREZ:580 UNIPROT:Q99728 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BARD1"/> <clone/> <bbox w="80.0" h="40.0" x="1312.5" y="7565.0"/> </glyph> <glyph class="macromolecule" id="s4543_sa3517" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BRCA1 associated RING domain 1 HUGO:BARD1 HGNC:952 ENTREZ:580 UNIPROT:Q99728 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="BARD1"/> <clone/> <bbox w="80.0" h="40.0" x="932.5" y="7585.0"/> </glyph> <glyph class="macromolecule" id="s4544_sa3509" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: family with sequence similarity 175, member A HUGO:FAM175A HGNC:25829 ENTREZ:84142 UNIPROT:Q6UWZ7 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:Abraxas synonym:ABRA1 synonym:CCDC98 References_end </body> </html> </notes> <label text="FAM175A"/> <bbox w="80.0" h="40.0" x="1312.5" y="7465.0"/> </glyph> <glyph class="macromolecule" id="s4558_sa3500" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 168, E3 ubiquitin protein ligase HUGO:RNF168 HGNC:26661 ENTREZ:165918 UNIPROT:Q8IYW5 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RNF168"/> <bbox w="80.0" h="40.0" x="1420.0" y="7780.0"/> </glyph> <glyph class="macromolecule" id="s4559_sa3501" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 8, E3 ubiquitin protein ligase HUGO:RNF8 HGNC:10071 ENTREZ:9025 UNIPROT:O76064 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="RNF8"/> <bbox w="80.0" h="40.0" x="1310.0" y="7790.0"/> </glyph> <glyph class="macromolecule" id="s4560_sa3513" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 binding protein 1 HUGO:TP53BP1 HGNC:11999 ENTREZ:7158 UNIPROT:Q12888 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:53BP1 References_end </body> </html> </notes> <label text="TP53BP1"/> <clone/> <bbox w="80.0" h="40.0" x="1417.5" y="7645.0"/> </glyph> <glyph class="macromolecule" id="s4560_sa3514" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 binding protein 1 HUGO:TP53BP1 HGNC:11999 ENTREZ:7158 UNIPROT:Q12888 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:53BP1 References_end </body> </html> </notes> <label text="TP53BP1"/> <clone/> <bbox w="80.0" h="40.0" x="1420.0" y="7720.0"/> </glyph> <glyph class="source and sink" id="s4561_sa3523" compartmentRef="c1_ca1"> <label text="s4561"/> <bbox w="30.0" h="30.0" x="6495.0" y="4785.0"/> </glyph> <glyph class="macromolecule" id="s4563_sa3525" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="cleaved~BCL2_XL*"/> <bbox w="80.0" h="40.0" x="5770.0" y="5080.0"/> <glyph class="unit of information" id="_1695180b-0160-4871-85ec-79ecfb7a20cf"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5785.0" y="5075.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4564_sa3526" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:DEPT References_end </body> </html> </notes> <label text="DEPDC6"/> <bbox w="80.0" h="40.0" x="9365.0" y="2495.0"/> <glyph class="state variable" id="_aba24617-ea7c-4771-8ab3-3a6ae10d414f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9416.568" y="2490.0"/> </glyph> </glyph> <glyph class="complex" id="s4570_csa370" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DEPDC6:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1:DEPTOR"/> <bbox w="179.0" h="111.0" x="9455.5" y="2599.5"/> <glyph class="macromolecule" id="s4566_sa3528"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="9462.5" y="2647.5"/> </glyph> <glyph class="macromolecule" id="s4568_sa3529"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="9545.5" y="2645.5"/> <glyph class="state variable" id="_04e76792-24d8-4891-b202-746f132dfeb6"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9587.449" y="2640.5"/> </glyph> <glyph class="state variable" id="_fa511873-8111-40e0-b055-922d9397c558"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="9554.095" y="2640.5"/> </glyph> <glyph class="state variable" id="_069eec2c-cb0d-460b-be0c-362570fbefd8"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9561.432" y="2680.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s4567_sa3530"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9462.5" y="2605.5"/> </glyph> <glyph class="macromolecule" id="s8327_sa5535"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:AUTOPHAGY Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:DEPT References_end </body> </html> </notes> <label text="DEPDC6"/> <bbox w="80.0" h="40.0" x="9545.0" y="2607.5"/> <glyph class="state variable" id="_25e38d19-5ff9-457e-867a-06ef48707062"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9596.568" y="2602.5"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4571_sa3535" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:DEPT References_end </body> </html> </notes> <label text="DEPDC6"/> <bbox w="80.0" h="40.0" x="9495.0" y="2495.0"/> <glyph class="state variable" id="_5ef88e7a-5a1c-432d-8d9f-808b5b8a211d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9544.068" y="2490.0"/> </glyph> </glyph> <glyph class="source and sink" id="s4572_sa3536" compartmentRef="c1_ca1"> <label text="s4572"/> <bbox w="30.0" h="30.0" x="9620.0" y="2500.0"/> </glyph> <glyph class="complex" id="s4579_csa372" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DEPDC6:MAPKAP1:MLST8:MTOR:RICTOR Identifiers_end </body> </html> </notes> <label text="mTORC2:DEPTOR"/> <bbox w="177.0" h="154.0" x="9456.5" y="2298.0"/> <glyph class="macromolecule" id="s4578_sa3527"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:DEPT References_end </body> </html> </notes> <label text="DEPDC6"/> <bbox w="80.0" h="40.0" x="9545.0" y="2385.0"/> <glyph class="state variable" id="_001896c6-931b-40e1-9b81-0f5088004666"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9596.568" y="2380.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4574_sa3537"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="9544.5" y="2303.0"/> </glyph> <glyph class="macromolecule" id="s4575_sa3538"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9462.5" y="2345.0"/> </glyph> <glyph class="macromolecule" id="s4576_sa3539"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RPTOR independent companion of MTOR, complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="9545.5" y="2345.0"/> </glyph> <glyph class="macromolecule" id="s4577_sa3540"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:SIN1 References_end </body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="9461.5" y="2303.0"/> </glyph> <glyph class="macromolecule" id="s4578_sa3541"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: synonym:DEPT References_end </body> </html> </notes> <label text="DEPDC6"/> <bbox w="80.0" h="40.0" x="9461.5" y="2388.0"/> <glyph class="state variable" id="_d9180323-67ca-440f-8898-4de5daba1b59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9513.068" y="2383.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4584_sa3542" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="332.76212" y="7215.572"/> <glyph class="state variable" id="_9013d435-a3f6-4c63-95c8-d7ef486c1e91"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="341.35715" y="7210.572"/> </glyph> <glyph class="state variable" id="_f7fe74c5-9f60-423d-8e8a-534c798fde0f"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="376.83066" y="7210.572"/> </glyph> </glyph> <glyph class="complex" id="s4588_csa5" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX Identifiers_end </body> </html> </notes> <label text="BAX oligomer"/> <bbox w="170.0" h="120.0" x="4616.75" y="5928.25"/> <glyph class="macromolecule" id="s4589_sa3564"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4667.1284" y="5948.129"/> <glyph class="state variable" id="_582d8b24-023f-434b-bfe8-9482055c119f"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4665.7056" y="5943.129"/> </glyph> <glyph class="state variable" id="_811b12a5-2cb0-46b6-8e4b-a33f7030f8a5"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4710.713" y="5943.129"/> </glyph> <glyph class="state variable" id="_7c7021b4-79ee-45c9-b7f3-d803ff6fa395"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4713.4497" y="5983.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3565"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4677.1284" y="5958.129"/> <glyph class="state variable" id="_c3c33c41-8936-4e5d-957e-05b17fc4cdaa"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4675.7056" y="5953.129"/> </glyph> <glyph class="state variable" id="_4d7c584d-59dd-4087-8cdb-7aae31e017e9"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4720.713" y="5953.129"/> </glyph> <glyph class="state variable" id="_c555a083-2d5f-4ee4-a8d9-b1311de598a5"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4723.4497" y="5993.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3566"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4687.1284" y="5968.129"/> <glyph class="state variable" id="_ea249e38-e894-436d-a673-21a55a828710"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4685.7056" y="5963.129"/> </glyph> <glyph class="state variable" id="_6f832288-9993-4578-a66e-095f92354c17"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4730.713" y="5963.129"/> </glyph> <glyph class="state variable" id="_8806abdf-1da8-45f1-97d3-806ebd6a3458"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4733.4497" y="6003.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3567"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4697.1284" y="5978.129"/> <glyph class="state variable" id="_a3f417bf-b3b4-4698-b6cf-a6f04bae1e7a"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4695.7056" y="5973.129"/> </glyph> <glyph class="state variable" id="_d39f2b5e-7aba-4e34-9641-e8e7505d5948"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4740.713" y="5973.129"/> </glyph> <glyph class="state variable" id="_30ec5af8-f320-4957-a88b-4024b2b3c578"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4743.4497" y="6013.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3568"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4633.1284" y="5948.129"/> <glyph class="state variable" id="_4355574d-c4e8-4f49-9c0b-0367d185a80b"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4631.7056" y="5943.129"/> </glyph> <glyph class="state variable" id="_0310e1c3-1141-4a16-a4f2-b7d979af8ad2"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4676.713" y="5943.129"/> </glyph> <glyph class="state variable" id="_04bd17fb-8bb7-4446-bb20-d510c6d36e78"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4679.4497" y="5983.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3569"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4643.1284" y="5958.129"/> <glyph class="state variable" id="_ec368219-27e4-42ab-8dee-39c7fe73451f"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4641.7056" y="5953.129"/> </glyph> <glyph class="state variable" id="_744bc5a8-db3f-4979-841a-e324306ddf7e"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4686.713" y="5953.129"/> </glyph> <glyph class="state variable" id="_fcb3a773-d38a-4bed-a6b2-435d3b06cc7a"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4689.4497" y="5993.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3570"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4653.1284" y="5968.129"/> <glyph class="state variable" id="_cbe783ba-00a8-45be-bb35-841895e0b058"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4651.7056" y="5963.129"/> </glyph> <glyph class="state variable" id="_4b6805ce-c7e6-4911-82a5-27ebaf43b7a7"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4696.713" y="5963.129"/> </glyph> <glyph class="state variable" id="_3cd17253-6654-485d-b260-693487a12323"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4699.4497" y="6003.129"/> </glyph> </glyph> <glyph class="macromolecule" id="s4589_sa3571"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="4663.1284" y="5978.129"/> <glyph class="state variable" id="_e5836542-601b-4ed1-af4c-48c7d7db686d"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="4661.7056" y="5973.129"/> </glyph> <glyph class="state variable" id="_82f58680-7b6e-49e7-88c7-9abf5019ca0e"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="4706.713" y="5973.129"/> </glyph> <glyph class="state variable" id="_2cc3df04-b1c0-40a4-b1f6-0f7e69c88424"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="4709.4497" y="6013.129"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4591_sa3196" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="5030.0" y="1450.0"/> <glyph class="state variable" id="_5be4cebb-3c7b-42dc-a785-222a602a1a5c"> <state value="oligomer" variable=""/> <bbox w="50.0" h="10.0" x="5045.0" y="1445.0"/> </glyph> <glyph class="state variable" id="_f94a5cdf-23d0-4ea6-ad02-9c6a87a42ca7"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="5038.595" y="1445.0"/> </glyph> <glyph class="state variable" id="_9646d44d-c907-468f-845b-d3a762ee9773"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5081.5684" y="1445.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4592_sa3193" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="5030.0" y="1660.0"/> <glyph class="state variable" id="_91a998db-a513-4353-a35c-11bc8bc09c1a"> <state value="oligomer" variable=""/> <bbox w="50.0" h="10.0" x="5045.0" y="1655.0"/> </glyph> <glyph class="state variable" id="_f69b443f-7a91-498e-b500-ff52e1819208"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="5038.595" y="1655.0"/> </glyph> <glyph class="state variable" id="_25e2717d-0eb4-4d25-9930-f02b2c824fb2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5079.0684" y="1655.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4595_sa3574" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NFKB1"/> <bbox w="80.0" h="40.0" x="6352.5" y="7455.0"/> </glyph> <glyph class="macromolecule" id="s4598_sa3580" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="3475.0" y="7505.0"/> <glyph class="state variable" id="_2c8fc02a-33b6-40be-8e27-8e7fa7807b54"> <state value="P" variable="S15"/> <bbox w="30.0" h="10.0" x="3516.9492" y="7500.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4601_sa3587" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <clone/> <bbox w="80.0" h="40.0" x="1578.875" y="4502.625"/> <glyph class="state variable" id="_9e9700d2-682e-4275-bc6a-2f21deabe9cd"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="1612.813" y="4497.625"/> </glyph> </glyph> <glyph class="macromolecule" id="s4601_sa3798" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <clone/> <bbox w="80.0" h="40.0" x="5803.25" y="4890.0"/> <glyph class="state variable" id="_0ae3f4ac-bcce-462f-87c1-05f8abc5e7c1"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="5837.188" y="4885.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4604_sa3591" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 12 (proline rich) HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="BCL2L12"/> <bbox w="80.0" h="40.0" x="4759.5474" y="3157.2693"/> </glyph> <glyph class="macromolecule" id="s4607_sa3592" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: synonym:cathepsins References_end </body> </html> </notes> <label text="CTSB"/> <bbox w="80.0" h="40.0" x="8029.5" y="6283.0"/> <glyph class="state variable" id="_e0de17ff-289f-4d9c-9e3c-6622f6f000d7"> <state value="Modification in lysosome " variable=""/> <bbox w="80.0" h="10.0" x="8029.5" y="6278.0"/> </glyph> <glyph class="state variable" id="_72fd5fb2-c62c-4751-9942-ca5a88e98f1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8024.5" y="6298.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4608_sa3593" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: synonym:cathepsins References_end </body> </html> </notes> <label text="CTSB"/> <bbox w="80.0" h="40.0" x="7040.0" y="2590.0"/> <glyph class="state variable" id="_e4b5940b-4c49-483e-ba01-d0e88dfdc288"> <state value="Modification in lysosome " variable=""/> <bbox w="80.0" h="10.0" x="7040.0" y="2585.0"/> </glyph> <glyph class="state variable" id="_d4d9e4a5-2605-4ffc-b7ca-b7f2824af0c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7035.0" y="2605.0"/> </glyph> </glyph> <glyph class="complex" id="s4609_csa373" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RHEB Identifiers_end </body> </html> </notes> <label text="RHEB*"/> <bbox w="99.0" h="91.0" x="8867.0" y="3143.0"/> <glyph class="macromolecule" id="s3600_sa2569"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Ras homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="8878.0" y="3160.0"/> <glyph class="state variable" id="_7d312df4-ef85-473d-b3e9-bcc71bc6ffc2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8896.432" y="3155.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4612_sa3596" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="5070.0" y="340.0"/> <glyph class="state variable" id="_fdac85c3-0c17-4dcf-9fa2-d3e91979f401"> <state value="unfolded" variable=""/> <bbox w="50.0" h="10.0" x="5085.0" y="335.0"/> </glyph> <glyph class="state variable" id="_d74f0935-afb5-4421-b3f9-fe0694c335eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5065.0" y="346.17117"/> </glyph> <glyph class="state variable" id="_7d97c9f6-710a-4552-b97a-314a6515d2d8"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="5135.0" y="346.25"/> </glyph> <glyph class="state variable" id="_f2cb23f3-5f98-4d0a-9989-6081172059de"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5107.8364" y="335.0"/> </glyph> <glyph class="state variable" id="_0d0bed59-d88e-447f-a16d-3ea3aeb9b023"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="5111.3306" y="375.0"/> </glyph> </glyph> <glyph class="complex" id="s4617_csa291" compartmentRef="c10_ca10"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1"/> <bbox w="100.0" h="165.0" x="2527.5" y="7755.0"/> <glyph class="macromolecule" id="s4618_sa2349"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="2537.5" y="7800.0"/> </glyph> <glyph class="macromolecule" id="s4619_sa2350"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="2537.5" y="7850.0"/> <glyph class="state variable" id="_a95cd880-2617-41e4-965a-b88daf718087"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="2579.4492" y="7845.0"/> </glyph> <glyph class="state variable" id="_860ddd8f-6421-43bd-b5c8-1001321c290c"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="2546.095" y="7845.0"/> </glyph> <glyph class="state variable" id="_ec8c1d5d-43bb-4278-bff3-9198a65d60bf"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="2553.4314" y="7885.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4620_sa2351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="2537.5" y="7760.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s4630_sa3601" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CID PMID:2828334 Necrostatin-1 (Nec-1; 5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one) PMID:18408713 References_end </body> </html> </notes> <label text="Necrostatin-1"/> <bbox w="90.0" h="35.0" x="4838.0" y="857.75"/> <glyph class="unit of information" id="_e9296e66-5099-48e1-bc9a-d3d666292cb9"> <label text="drug"/> <bbox w="25.0" h="10.0" x="4870.5" y="852.75"/> </glyph> </glyph> <glyph class="simple chemical" id="s4680_sa3085" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end </body> </html> </notes> <label text="ATP"/> <bbox w="70.0" h="25.0" x="3035.0" y="4347.5"/> </glyph> <glyph class="simple chemical" id="s4681_sa3086" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16761 KEGGCOMPOUND:C00008 CAS:58-64-0 Identifiers_end </body> </html> </notes> <label text="ADP"/> <bbox w="70.0" h="25.0" x="2955.0" y="4347.5"/> </glyph> <glyph class="macromolecule" id="s4688_sa2176" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <clone/> <bbox w="80.0" h="40.0" x="3828.0" y="4279.0"/> <glyph class="state variable" id="_7a75a877-b478-4954-bf54-f1f0b00d332e"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="3840.5" y="4274.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4688_sa2534" compartmentRef="c3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <clone/> <bbox w="80.0" h="40.0" x="3119.6653" y="4289.2583"/> <glyph class="state variable" id="_2227cd35-d733-4ed4-9799-1ffc6cb99232"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="3132.1653" y="4284.2583"/> </glyph> </glyph> <glyph class="simple chemical" id="s4689_sa2180" compartmentRef="c3_ca3"> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="1138.7739" y="3908.25"/> </glyph> <glyph class="simple chemical" id="s4689_sa2219" compartmentRef="c3_ca3"> <label text="CO2"/> <clone/> <bbox w="70.0" h="25.0" x="1110.75" y="4120.25"/> </glyph> <glyph class="macromolecule" id="s4770_sa3161" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 2, catalytic subunit, beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 protein phosphatase 2, regulatory subunit A, alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:18292600 AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation. References_end </body> </html> </notes> <label text="PP2A*"/> <clone/> <bbox w="80.0" h="40.0" x="4724.5" y="1312.0"/> </glyph> <glyph class="macromolecule" id="s4770_sa3235" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 2, catalytic subunit, beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 protein phosphatase 2, regulatory subunit A, alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:18292600 AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation. References_end </body> </html> </notes> <label text="PP2A*"/> <clone/> <bbox w="80.0" h="40.0" x="6400.0" y="590.0"/> </glyph> <glyph class="macromolecule" id="s4777_sa1238" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) HUGO:MAFK HGNC:6782 ENTREZ:7975 UNIPROT:O60675 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) HUGO:MAFG HGNC:6781 ENTREZ:4097 UNIPROT:O15525 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: genetic entity References_end </body> </html> </notes> <label text="small~MAF*"/> <bbox w="80.0" h="40.0" x="7282.5" y="7905.0"/> </glyph> <glyph class="simple chemical" id="s4795_sa1183" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15379 KEGGCOMPOUND:C00007 CAS:7782-44-7 Identifiers_end </body> </html> </notes> <label text="O2"/> <bbox w="70.0" h="25.0" x="5967.5" y="7752.5"/> </glyph> <glyph class="macromolecule" id="s4796_sa1184" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <clone/> <bbox w="80.0" h="40.0" x="6042.5" y="7605.0"/> <glyph class="state variable" id="_b372bd15-5eaf-4a30-b037-938e68ed1188"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="6051.095" y="7600.0"/> </glyph> <glyph class="state variable" id="_0367657e-1e88-4f56-add3-57fb796d1392"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6094.0684" y="7600.0"/> </glyph> <glyph class="state variable" id="_66c28721-b31f-41cb-9728-abda41dab72d"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="6050.001" y="7640.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4796_sa3583" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <clone/> <bbox w="80.0" h="40.0" x="5385.0" y="7435.0"/> <glyph class="state variable" id="_7cd678ad-13ca-4170-9d24-4ab1e72cb0c2"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="5393.595" y="7430.0"/> </glyph> <glyph class="state variable" id="_1f934ce5-14ed-4cd9-8b7b-ff278062ca1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5436.5684" y="7430.0"/> </glyph> <glyph class="state variable" id="_79db2488-a49f-4a11-acca-ea6425d4bf47"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="5392.501" y="7470.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4797_sa1848" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <clone/> <bbox w="80.0" h="40.0" x="6902.5" y="7815.0"/> </glyph> <glyph class="macromolecule" id="s4797_sa3582" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <clone/> <bbox w="80.0" h="40.0" x="6902.5" y="7475.0"/> </glyph> <glyph class="macromolecule" id="s4799_sa2327" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <clone/> <bbox w="80.0" h="40.0" x="7440.0" y="7760.0"/> </glyph> <glyph class="macromolecule" id="s4799_sa3581" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <clone/> <bbox w="80.0" h="40.0" x="7122.5" y="7545.0"/> </glyph> <glyph class="macromolecule" id="s4800_sa2430" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 References_end </body> </html> </notes> <label text="FOXO*"/> <clone/> <bbox w="80.0" h="40.0" x="5302.5" y="7935.0"/> <glyph class="state variable" id="_8956dd13-1a89-447d-8714-33bf94106e58"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5354.189" y="7930.0"/> </glyph> <glyph class="state variable" id="_1d199919-263c-4fec-8fa1-f83d1f3ac5ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5320.9316" y="7930.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4800_sa3579" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 References_end </body> </html> </notes> <label text="FOXO*"/> <clone/> <bbox w="80.0" h="40.0" x="4965.0" y="7515.0"/> <glyph class="state variable" id="_f4035bfd-b8d1-4344-9bd9-d45c4313add8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5016.689" y="7510.0"/> </glyph> <glyph class="state variable" id="_c5405d62-c94d-4230-af69-db4e89edd938"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4983.4316" y="7510.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4801_sa2414" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: estrogen-related receptor alpha HUGO:ESRRA HGNC:3471 ENTREZ:2101 UNIPROT:P11474 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ESRRA"/> <bbox w="80.0" h="40.0" x="2352.5" y="7465.0"/> </glyph> <glyph class="macromolecule" id="s4811_sa593" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: E2F1 References_end </body> </html> </notes> <label text="E2F1"/> <clone/> <bbox w="80.0" h="40.0" x="4232.5" y="7485.0"/> </glyph> <glyph class="macromolecule" id="s4811_sa3572" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: E2F1 References_end </body> </html> </notes> <label text="E2F1"/> <clone/> <bbox w="80.0" h="40.0" x="4232.5" y="7585.0"/> </glyph> <glyph class="macromolecule" id="s4836_sa3602" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <clone/> <bbox w="80.0" h="40.0" x="1458.0514" y="99.43111"/> </glyph> <glyph class="macromolecule" id="s4836_sa4103" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <clone/> <bbox w="80.0" h="40.0" x="2048.0515" y="79.43111"/> </glyph> <glyph class="macromolecule" id="s4836_sa4104" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <clone/> <bbox w="80.0" h="40.0" x="2578.0515" y="79.43111"/> </glyph> <glyph class="macromolecule" id="s4838_sa3604" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sonic hedgehog HUGO:SHH HGNC:10848 ENTREZ:6469 UNIPROT:Q15465 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 In the absence of SHH; Patched recruits a dral-tucan complex that lead to apoptosis References_end </body> </html> </notes> <label text="SHH"/> <bbox w="80.0" h="40.0" x="2940.0" y="120.0"/> </glyph> <glyph class="macromolecule" id="s4839_sa3605" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:19465923 PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9 References_end </body> </html> </notes> <label text="PTCH*"/> <bbox w="80.0" h="50.0" x="2950.0" y="185.0"/> <glyph class="unit of information" id="_13fd1391-3d40-41e5-87ef-7dc89cd0e838"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2967.5" y="180.0"/> </glyph> </glyph> <glyph class="complex" id="s4847_csa374" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FADD:RIPK1:RIPK3 Identifiers_end References_begin: 23010170 RIP1 deubiquitination leads to the formation of complex II which is composed of TRADD, FADD, RIP1 and caspase-8 PMID:23073834 PMID:22421439 PMID:12887920 If caspase 8 is inhibited, necroptosis is triggered. References_end </body> </html> </notes> <label text="Complex IIB"/> <bbox w="100.0" h="170.0" x="2480.5" y="532.0"/> <glyph class="macromolecule" id="s4848_sa3598"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="2490.5" y="642.0"/> <glyph class="state variable" id="_b3c0124a-e3e8-4ee9-a081-bacff64d31b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2485.5" y="648.17114"/> </glyph> <glyph class="state variable" id="_e2246930-05eb-48b4-a664-d5b1834b750f"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="2555.5" y="648.25"/> </glyph> <glyph class="state variable" id="_394ed906-ca7a-4afd-bc41-a2dedd8be3c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2528.3367" y="637.0"/> </glyph> <glyph class="state variable" id="_ffe76569-2363-46d7-81a1-ba0f5d322e45"> <state value="P" variable="S161"/> <bbox w="35.0" h="10.0" x="2529.3306" y="677.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4849_sa3599"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="2490.5" y="592.0"/> <glyph class="state variable" id="_51ad9435-ea80-4e52-8638-d14b47bf097c"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="2475.9924" y="587.0"/> </glyph> <glyph class="state variable" id="_2c0a0038-6f27-4936-b336-2426a1f37abb"> <state value="P" variable="S199"/> <bbox w="35.0" h="10.0" x="2529.9492" y="587.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4850_sa3600"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="2490.5" y="542.0"/> </glyph> </glyph> <glyph class="complex" id="s4858_csa378" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FADD:GLUD1:GLUL:MLKL:PGAM5:PYGL:RIPK1:RIPK3 Identifiers_end References_begin: PMID:22421439 PMID:17603935 PMID:16469705 The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. FADD:MLKL:PYGL:RIPK3:RIPK1:PGAM5:GLUL:GLUD1 PMID:23073834 New components of the necroptotic pathway. PMID:19632174 RIP3 directly interacts with glycogen phosphorylase (PYGL), glutamate ammonia ligase (GLUL), and glutamate dehydrogenase 1 (GLUD1) PMID:26807733 Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis. References_end </body> </html> </notes> <label text="Necrosome"/> <bbox w="310.0" h="240.0" x="2380.5" y="872.0"/> <glyph class="macromolecule" id="s4857_sa3609"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="2500.5" y="992.0"/> <glyph class="state variable" id="_c6d7d038-80ff-4c2d-946b-88dba47d7563"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2495.5" y="998.17114"/> </glyph> <glyph class="state variable" id="_a8cfa0eb-fe4a-4348-85a4-bef201f89ad7"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="2565.5" y="998.25"/> </glyph> <glyph class="state variable" id="_13698601-5bc6-4611-a401-15277a86d252"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2538.3367" y="987.0"/> </glyph> <glyph class="state variable" id="_fc6484da-19b4-4e74-a678-f1ec8fbb1f9e"> <state value="P" variable="S161"/> <bbox w="35.0" h="10.0" x="2539.3306" y="1027.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4859_sa3610"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="2500.5" y="942.0"/> <glyph class="state variable" id="_81716747-1baf-466d-b1ce-6a3badff185e"> <state value="P" variable="S227"/> <bbox w="35.0" h="10.0" x="2483.4924" y="937.0"/> </glyph> <glyph class="state variable" id="_0d86b81a-d7a7-4038-89aa-54e2225c941f"> <state value="P" variable="S199"/> <bbox w="35.0" h="10.0" x="2539.9492" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4860_sa3611"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="2500.5" y="882.0"/> </glyph> <glyph class="macromolecule" id="s4851_sa3618"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Phosphorylated by RIP3 MLKL become active (phosphorylation activity) PMID: 23073834 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mixed lineage kinase domain-like HUGO:MLKL HGNC:26617 ENTREZ:197259 UNIPROT:Q8NB16 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 PMID:24366341 PMID:26024392 PMID:26853145 Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. PMID:28498367 References_end </body> </html> </notes> <label text="MLKL"/> <bbox w="80.0" h="40.0" x="2400.5" y="942.0"/> <glyph class="state variable" id="_c03053f3-ccb1-4010-911a-ea0e80558ec8"> <state value="P" variable="T357"/> <bbox w="35.0" h="10.0" x="2383.0" y="948.5066"/> </glyph> <glyph class="state variable" id="_bafb084a-aed4-4fc2-b252-7fde8cf34767"> <state value="P" variable="S358"/> <bbox w="35.0" h="10.0" x="2406.595" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4864_sa3629"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutamate-ammonia ligase HUGO:GLUL HGNC:4341 ENTREZ:2752 UNIPROT:P15104 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUL"/> <bbox w="80.0" h="40.0" x="2590.5" y="942.0"/> <glyph class="state variable" id="_830ca4ff-d1aa-47fd-a860-763959f232ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2642.0686" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4865_sa3630"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutamate dehydrogenase 1 HUGO:GLUD1 HGNC:4335 ENTREZ:2746 UNIPROT:P00367 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUD1"/> <bbox w="80.0" h="40.0" x="2590.5" y="992.0"/> <glyph class="state variable" id="_8963bff7-41da-4eb8-82eb-c123cb7b0d33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2642.0686" y="987.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4868_sa3634"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphorylase, glycogen, liver HUGO:PYGL HGNC:9725 ENTREZ:5836 UNIPROT:P06737 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23010170 PMID:20823910 PYGL catalyses the breakdown of glycogen into glucose-1-phosphate (glycogenolysis), which can be converted into the glycolytic substrate glucose-6-phosphate87, thereby stimulating glycolysis (which eventually contributes to ROS generation). PMID:23627914 Glycogen phosphorylase (GP) is the enzyme responsible for the synthesis of glucose-1-phosphate References_end </body> </html> </notes> <label text="PYGL"/> <bbox w="80.0" h="40.0" x="2400.5" y="992.0"/> </glyph> <glyph class="macromolecule" id="s4875_sa3645"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Phosphorylated by RIPK3 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglycerate mutase family member 5 HUGO:PGAM5 HGNC:28763 ENTREZ:192111 UNIPROT:Q96HS1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23010170 PGAM5 promotes necroptosis through the dephosphorylation of Drp1 PMID:23073834 PMID:22265414 The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. References_end </body> </html> </notes> <label text="PGAM5"/> <bbox w="80.0" h="40.0" x="2500.5" y="1042.0"/> <glyph class="state variable" id="_0d35aea3-821d-4ff5-98bd-06e760167966"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2573.0" y="1057.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s4861_sa3625" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28645028 PMID:24366341 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mixed lineage kinase domain-like HUGO:MLKL HGNC:26617 ENTREZ:197259 UNIPROT:Q8NB16 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 PMID:24366341 PMID:26024392 PMID:26853145 Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. PMID:28498367 References_end </body> </html> </notes> <label text="MLKL"/> <clone/> <bbox w="80.0" h="40.0" x="2318.0" y="727.0"/> <glyph class="state variable" id="_c6a7b1fb-58fe-4815-97b2-ea72513ecb8a"> <state value="" variable="T357"/> <bbox w="30.0" h="10.0" x="2303.0" y="733.5066"/> </glyph> <glyph class="state variable" id="_aa6c1497-caab-4e7e-b231-d0840d61ac40"> <state value="" variable="S358"/> <bbox w="30.0" h="10.0" x="2326.595" y="722.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4861_sa3940" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28645028 PMID:24366341 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mixed lineage kinase domain-like HUGO:MLKL HGNC:26617 ENTREZ:197259 UNIPROT:Q8NB16 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 PMID:24366341 PMID:26024392 PMID:26853145 Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. PMID:28498367 References_end </body> </html> </notes> <label text="MLKL"/> <clone/> <bbox w="80.0" h="40.0" x="7470.0" y="540.0"/> <glyph class="state variable" id="_b38d2641-3854-4e8c-9fd0-6a250f8c567e"> <state value="" variable="T357"/> <bbox w="30.0" h="10.0" x="7455.0" y="546.5066"/> </glyph> <glyph class="state variable" id="_1ca0df07-c644-4c3f-880a-e9f05d28027e"> <state value="" variable="S358"/> <bbox w="30.0" h="10.0" x="7478.595" y="535.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4866_sa3631" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphorylase, glycogen, liver HUGO:PYGL HGNC:9725 ENTREZ:5836 UNIPROT:P06737 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23010170 PMID:20823910 PYGL catalyses the breakdown of glycogen into glucose-1-phosphate (glycogenolysis), which can be converted into the glycolytic substrate glucose-6-phosphate87, thereby stimulating glycolysis (which eventually contributes to ROS generation). PMID:23627914 Glycogen phosphorylase (GP) is the enzyme responsible for the synthesis of glucose-1-phosphate References_end </body> </html> </notes> <label text="PYGL"/> <clone/> <bbox w="80.0" h="40.0" x="2590.0" y="770.0"/> </glyph> <glyph class="macromolecule" id="s4866_sa3781" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphorylase, glycogen, liver HUGO:PYGL HGNC:9725 ENTREZ:5836 UNIPROT:P06737 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUCOSE_METABOLISM MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23010170 PMID:20823910 PYGL catalyses the breakdown of glycogen into glucose-1-phosphate (glycogenolysis), which can be converted into the glycolytic substrate glucose-6-phosphate87, thereby stimulating glycolysis (which eventually contributes to ROS generation). PMID:23627914 Glycogen phosphorylase (GP) is the enzyme responsible for the synthesis of glucose-1-phosphate References_end </body> </html> </notes> <label text="PYGL"/> <clone/> <bbox w="80.0" h="40.0" x="390.0" y="760.0"/> </glyph> <glyph class="macromolecule" id="s4869_sa3635" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glutamate dehydrogenase 1 HUGO:GLUD1 HGNC:4335 ENTREZ:2746 UNIPROT:P00367 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GLUD1"/> <bbox w="80.0" h="40.0" x="2590.0" y="720.0"/> <glyph class="state variable" id="_b6ef0907-d3f3-4284-a931-111e046f894f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2641.5686" y="715.0"/> </glyph> </glyph> <glyph class="phenotype" id="s4870_sa3640" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: vicious cycles of damage favour the opening of the permeability-transition pore complex increasing ROS production as a consequence of energy metabolism PMID:19632174 PMID:20823910 PMID:18309324 PMID:27646922 References_end </body> </html> </notes> <label text="ROS Production"/> <clone/> <bbox w="110.0" h="25.0" x="2484.5" y="1279.5"/> </glyph> <glyph class="phenotype" id="s4870_sa3765" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: vicious cycles of damage favour the opening of the permeability-transition pore complex increasing ROS production as a consequence of energy metabolism PMID:19632174 PMID:20823910 PMID:18309324 PMID:27646922 References_end </body> </html> </notes> <label text="ROS Production"/> <clone/> <bbox w="117.5" h="40.0" x="6291.25" y="4230.0"/> </glyph> <glyph class="phenotype" id="s4870_sa3790" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: vicious cycles of damage favour the opening of the permeability-transition pore complex increasing ROS production as a consequence of energy metabolism PMID:19632174 PMID:20823910 PMID:18309324 PMID:27646922 References_end </body> </html> </notes> <label text="ROS Production"/> <clone/> <bbox w="97.5" h="30.0" x="1731.25" y="1225.0"/> </glyph> <glyph class="phenotype" id="s4871_sa3641" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: GLUL is a cytosolic enzyme that catalyzes the condensation of glutamate and ammonia to form glutamine, whereas GLUD1 is found in the mitochondrial matrix and converts glutamate to α-ketoglutarate References_end </body> </html> </notes> <label text="Glutaminolysis"/> <bbox w="100.0" h="25.0" x="2567.5" y="1199.5"/> </glyph> <glyph class="phenotype" id="s4874_sa3644" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PYGL catalyzes the degradation of glycogen by releasing glucose-1-phosphate and so plays a key role in utilizing glycogen reserves as an energy source References_end </body> </html> </notes> <label text="Glycogen breakdown"/> <bbox w="140.0" h="25.0" x="2407.5" y="1197.0"/> </glyph> <glyph class="macromolecule" id="s4877_sa3647" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:26807733 Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglycerate mutase family member 5 HUGO:PGAM5 HGNC:28763 ENTREZ:192111 UNIPROT:Q96HS1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23010170 PGAM5 promotes necroptosis through the dephosphorylation of Drp1 PMID:23073834 PMID:22265414 The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. References_end </body> </html> </notes> <label text="PGAM5"/> <bbox w="80.0" h="40.0" x="2320.5" y="772.0"/> <glyph class="state variable" id="_7f956204-c0b6-4f2f-9767-621a7184bf61"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2395.5" y="787.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4878_sa3649" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dynamin 1-like HUGO:DNM1L HGNC:2973 ENTREZ:10059 UNIPROT:O00429 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23073834 PMID:23010170 recruted by PGAM5 References_end </body> </html> </notes> <label text="Drp1*"/> <clone/> <bbox w="80.0" h="40.0" x="2230.5" y="1022.0"/> <glyph class="state variable" id="_14b4448b-2381-48de-80f1-46d7640dded1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2248.9314" y="1017.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4878_sa4496" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dynamin 1-like HUGO:DNM1L HGNC:2973 ENTREZ:10059 UNIPROT:O00429 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23073834 PMID:23010170 recruted by PGAM5 References_end </body> </html> </notes> <label text="Drp1*"/> <clone/> <bbox w="80.0" h="40.0" x="10056.561" y="3588.25"/> <glyph class="state variable" id="_1077fd0e-dba4-49ff-90c2-7c96cf95aad0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10074.992" y="3583.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s4879_sa3648" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dynamin 1-like HUGO:DNM1L HGNC:2973 ENTREZ:10059 UNIPROT:O00429 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23073834 PMID:23010170 recruted by PGAM5 References_end </body> </html> </notes> <label text="Drp1*"/> <clone/> <bbox w="80.0" h="40.0" x="2230.5" y="922.0"/> <glyph class="state variable" id="_b636cfb9-1cb5-4868-aac0-a508c8b09861"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2246.4314" y="917.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4879_sa4495" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dynamin 1-like HUGO:DNM1L HGNC:2973 ENTREZ:10059 UNIPROT:O00429 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23073834 PMID:23010170 recruted by PGAM5 References_end </body> </html> </notes> <label text="Drp1*"/> <clone/> <bbox w="80.0" h="40.0" x="10055.0" y="3465.0"/> <glyph class="state variable" id="_4cbdb03b-d8db-4b18-aa00-5e9e33cf23b0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10070.932" y="3460.0"/> </glyph> </glyph> <glyph class="phenotype" id="s4880_sa3650" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23073834 References_end </body> </html> </notes> <label text="Mitochondrial fission"/> <clone/> <bbox w="140.0" h="25.0" x="2200.0" y="1127.5"/> </glyph> <glyph class="phenotype" id="s4880_sa4497" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23073834 References_end </body> </html> </notes> <label text="Mitochondrial fission"/> <clone/> <bbox w="140.0" h="25.0" x="10026.561" y="3675.75"/> </glyph> <glyph class="macromolecule" id="s4887_sa3665" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CASP8 and FADD-like apoptosis regulator HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:15760909 PMID:19838173 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce References_end </body> </html> </notes> <label text="CFLAR"/> <bbox w="80.0" h="40.0" x="4400.0" y="1747.0"/> <glyph class="state variable" id="_22103a88-9016-4e22-8a4e-ce31ff4d24a9"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4446.5684" y="1742.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4888_sa1914" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: intraflagellar transport 57 homolog (Chlamydomonas) HUGO:IFT57 HGNC:17367 ENTREZ:55081 UNIPROT:Q9NWB7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="IFT57"/> <bbox w="80.0" h="40.0" x="7517.0" y="3903.0"/> </glyph> <glyph class="macromolecule" id="s4889_sa1913" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: huntingtin interacting protein 1 HUGO:HIP1 HGNC:4913 ENTREZ:3092 UNIPROT:O00291 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HIP1"/> <bbox w="80.0" h="40.0" x="7520.0" y="3960.0"/> </glyph> <glyph class="phenotype" id="s4890_sa3667" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20823910 PMID:11907276 Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. PMID:15145826 Alkylating DNA damage stimulates a regulated form of necrotic cell death. Cell death is determined by the effect of PARP-mediated beta-nicotinamide adenine dinucleotide (NAD) consumption on cellular metabolism References_end </body> </html> </notes> <label text="PARP activation"/> <bbox w="120.0" h="25.0" x="2267.5" y="1197.0"/> </glyph> <glyph class="complex" id="s4899_csa380" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CYBA:FAD:FADD:NOX*:NOXA*:NOXO*:RAC1_2*:RIPK1:TRADD:heme Identifiers_end References_begin: 17560373 References_end </body> </html> </notes> <label text="NADPH oxidase"/> <bbox w="336.25" h="160.0" x="6521.875" y="1370.0"/> <glyph class="macromolecule" id="s4252_sa3671"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NADPH oxidase 1 HUGO:NOX1 HGNC:7889 ENTREZ:27035 UNIPROT:Q9Y5S8 cytochrome b-245, beta polypeptide HUGO:CYBB HGNC:2578 ENTREZ:1536 UNIPROT:P04839 NADPH oxidase 3 HUGO:NOX3 HGNC:7890 ENTREZ:50508 UNIPROT:Q9HBY0 NADPH oxidase 4 HUGO:NOX4 HGNC:7891 ENTREZ:50507 UNIPROT:Q9NPH5 NADPH oxidase, EF-hand calcium binding domain 5 HUGO:NOX5 HGNC:14874 ENTREZ:79400 UNIPROT:Q96PH1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOX*"/> <bbox w="80.0" h="40.0" x="6768.125" y="1430.0"/> </glyph> <glyph class="macromolecule" id="s4254_sa3672"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome b-245, alpha polypeptide HUGO:CYBA HGNC:2577 ENTREZ:1535 UNIPROT:P13498 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:p22phox References_end </body> </html> </notes> <label text="CYBA"/> <bbox w="80.0" h="40.0" x="6768.125" y="1480.0"/> </glyph> <glyph class="simple chemical" id="s4242_sa3673"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:30413 </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="6693.125" y="1437.5"/> </glyph> <glyph class="macromolecule" id="s4258_sa3674"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: neutrophil cytosolic factor 1 HUGO:NCF1 HGNC:7660 ENTREZ:653361 UNIPROT:P14598 NADPH oxidase organizer 1 HUGO:NOXO1 HGNC:19404 ENTREZ:124056 UNIPROT:Q8NFA2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXO*"/> <bbox w="80.0" h="40.0" x="6528.125" y="1430.0"/> </glyph> <glyph class="macromolecule" id="s4078_sa3675"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: neutrophil cytosolic factor 2 HUGO:NCF2 HGNC:7661 ENTREZ:4688 UNIPROT:P19878 NADPH oxidase activator 1 HUGO:NOXA1 HGNC:10668 ENTREZ:10811 UNIPROT:Q86UR1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="NOXA*"/> <bbox w="80.0" h="40.0" x="6528.125" y="1480.0"/> </glyph> <glyph class="simple chemical" id="s4260_sa3676"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="6613.125" y="1437.5"/> </glyph> <glyph class="macromolecule" id="s4256_sa3677"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC2 HGNC:9802 ENTREZ:5880 UNIPROT:P15153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27331412 Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis. References_end </body> </html> </notes> <label text="RAC1_2*"/> <bbox w="80.0" h="40.0" x="6650.625" y="1467.5"/> </glyph> <glyph class="macromolecule" id="s4909_sa3678"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TRADD"/> <bbox w="80.0" h="40.0" x="6648.125" y="1380.0"/> </glyph> <glyph class="macromolecule" id="s4908_sa3679"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="6770.625" y="1377.5"/> <glyph class="state variable" id="_926c8cca-ee06-40ad-83ff-8b5fd17bcf17"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6765.625" y="1383.6711"/> </glyph> <glyph class="state variable" id="_1aa92e8d-a160-4d0a-aa8e-0a32d284e22d"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="6835.625" y="1383.75"/> </glyph> <glyph class="state variable" id="_a361b900-7764-40be-823e-e7ca319a3c6e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6808.4614" y="1372.5"/> </glyph> <glyph class="state variable" id="_179720b0-680c-44f1-ad1b-02938056d3b8"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="6811.9556" y="1412.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s8335_sa5536"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="6541.5" y="1377.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s4917_sa3680" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:64585 Identifiers_end </body> </html> </notes> <label text="Sphingomyelin"/> <bbox w="97.5" h="27.5" x="2541.25" y="1426.25"/> </glyph> <glyph class="simple chemical" id="s4918_sa3681" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17761 Identifiers_end References_begin: PMID:16716889 References_end </body> </html> </notes> <label text="Ceramide"/> <bbox w="70.0" h="25.0" x="2567.5" y="1702.5"/> </glyph> <glyph class="simple chemical" id="s4919_sa3682" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:57756 Identifiers_end References_begin: PMID:16716889 PMID:9443821 phingosine potentiates the transduction process of stimulus-PLA2 activation, resulting in enhancement of arachidonic acid liberation References_end </body> </html> </notes> <label text="Sphingosine"/> <bbox w="93.5" h="30.833334" x="2563.25" y="1874.5834"/> </glyph> <glyph class="simple chemical" id="s4920_sa3683" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 37550 PMID:23563662 Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway References_end </body> </html> </notes> <label text="Sphingosine-1-P"/> <bbox w="120.0" h="26.25" x="2550.0" y="2103.75"/> </glyph> <glyph class="simple chemical" id="s4921_sa3684" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 18368 References_end </body> </html> </notes> <label text="Glucosylceramide"/> <bbox w="115.0" h="22.5" x="2312.5" y="1708.75"/> </glyph> <glyph class="simple chemical" id="s4922_sa3685" compartmentRef="c1_ca1"> <label text="Lactosylceramide"/> <bbox w="115.5" h="22.5" x="2312.5" y="1882.5"/> </glyph> <glyph class="macromolecule" id="s4923_sa3686" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UDP-glucose ceramide glucosyltransferase HUGO:UGCG HGNC:12524 ENTREZ:7357 UNIPROT:Q16739 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="UGCG"/> <bbox w="80.0" h="40.0" x="2456.25" y="1782.5"/> </glyph> <glyph class="macromolecule" id="s4924_sa3687" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 HUGO:B4GALT6 HGNC:929 ENTREZ:9331 UNIPROT:Q9UBX8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="B4GALT6"/> <bbox w="80.0" h="40.0" x="2180.0" y="1790.0"/> </glyph> <glyph class="macromolecule" id="s4925_sa3688" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: alkaline ceramidase 1 HUGO:ACER1 HGNC:18356 ENTREZ:125981 UNIPROT:Q8TDN7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:16716889 Nitric oxide (NO) is known to activate N-ceramidase degradation through the ubiquitine/proteasome pathway. References_end </body> </html> </notes> <label text="ACER*"/> <bbox w="80.0" h="40.0" x="2800.0" y="1780.0"/> <glyph class="state variable" id="_d7fa8469-16c4-407a-b510-0794de56e301"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2851.5686" y="1775.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4926_sa3689" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingosine kinase 1 HUGO:SPHK1 HGNC:11240 ENTREZ:8877 UNIPROT:Q9NYA1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SPHK*"/> <bbox w="80.0" h="40.0" x="2470.0" y="2020.0"/> </glyph> <glyph class="macromolecule" id="s4927_sa3690" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingomyelin phosphodiesterase 1, acid lysosomal HUGO:SMPD1 HGNC:11120 ENTREZ:6609 UNIPROT:P17405 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16716889 Upon ligation of TNF-α, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase PMID:12531547 PMID:8663014 References_end </body> </html> </notes> <label text="SMPD1"/> <clone/> <bbox w="80.0" h="40.0" x="2402.5" y="1505.0"/> </glyph> <glyph class="macromolecule" id="s4927_sa3709" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingomyelin phosphodiesterase 1, acid lysosomal HUGO:SMPD1 HGNC:11120 ENTREZ:6609 UNIPROT:P17405 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16716889 Upon ligation of TNF-α, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase PMID:12531547 PMID:8663014 References_end </body> </html> </notes> <label text="SMPD1"/> <clone/> <bbox w="80.0" h="40.0" x="4710.0" y="280.0"/> </glyph> <glyph class="macromolecule" id="s4928_sa3691" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) HUGO:SMPD2 HGNC:11121 ENTREZ:6610 UNIPROT:O60906 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SMPD2"/> <bbox w="80.0" h="40.0" x="3004.5" y="1400.0"/> </glyph> <glyph class="macromolecule" id="s4929_sa3692" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) HUGO:SMPD3 HGNC:14240 ENTREZ:55512 UNIPROT:Q9NY59 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SMPD3"/> <bbox w="80.0" h="40.0" x="3004.5" y="1460.0"/> </glyph> <glyph class="macromolecule" id="s4930_sa3693" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) HUGO:SMPD4 HGNC:32949 ENTREZ:55627 UNIPROT:Q9NXE4 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SMPD4"/> <bbox w="80.0" h="40.0" x="3004.5" y="1520.0"/> </glyph> <glyph class="macromolecule" id="s4931_sa3694" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutral sphingomyelinase (N-SMase) activation associated factor HUGO:NSMAF HGNC:8017 ENTREZ:8439 UNIPROT:Q92636 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:16716889 PMID:28765050 References_end </body> </html> </notes> <label text="N-SMase*"/> <bbox w="80.0" h="40.0" x="2840.0" y="1460.0"/> </glyph> <glyph class="simple chemical" id="s4932_sa3697" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:295975 Identifiers_end </body> </html> </notes> <label text="Choline Phosphate"/> <bbox w="125.0" h="22.5" x="2460.0" y="1633.75"/> </glyph> <glyph class="simple chemical" id="s4935_sa3701" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 35757 References_end </body> </html> </notes> <label text="Carboxylate"/> <bbox w="85.0" h="22.5" x="2625.0" y="1847.5"/> </glyph> <glyph class="simple chemical" id="s4936_sa3704" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 18066 References_end </body> </html> </notes> <label text="UDP-Glucose"/> <bbox w="85.0" h="22.5" x="2382.5" y="1742.5"/> </glyph> <glyph class="simple chemical" id="s4937_sa3706" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ChEBI: 18307 References_end </body> </html> </notes> <label text="UDP-alpha-D-galactose"/> <bbox w="155.0" h="32.5" x="2182.5" y="1743.75"/> </glyph> <glyph class="macromolecule" id="s4941_sa3713" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutral sphingomyelinase (N-SMase) activation associated factor HUGO:NSMAF HGNC:8017 ENTREZ:8439 UNIPROT:Q92636 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:12404124 PMID:11435466 PMID:16716889 PMID:28765050 References_end </body> </html> </notes> <label text="NSMAF"/> <clone/> <bbox w="80.0" h="40.0" x="2400.0" y="1430.0"/> <glyph class="state variable" id="_3dbf2abc-5def-4265-8b4c-8c0be6f94d16"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2418.4314" y="1425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4941_sa4299" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutral sphingomyelinase (N-SMase) activation associated factor HUGO:NSMAF HGNC:8017 ENTREZ:8439 UNIPROT:Q92636 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:12404124 PMID:11435466 PMID:16716889 PMID:28765050 References_end </body> </html> </notes> <label text="NSMAF"/> <clone/> <bbox w="80.0" h="40.0" x="4710.0" y="340.0"/> <glyph class="state variable" id="_279a33e9-63ef-42b1-8191-0f150a01d691"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4728.4316" y="335.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4943_sa3717" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanylate cyclase 1, soluble, alpha 2 HUGO:GUCY1A2 HGNC:4684 ENTREZ:2977 UNIPROT:P33402 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GUCY1A2"/> <bbox w="80.0" h="40.0" x="2070.0" y="1580.0"/> </glyph> <glyph class="macromolecule" id="s4944_sa3718" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanylate cyclase 1, soluble, beta 3 HUGO:GUCY1B3 HGNC:4687 ENTREZ:2983 UNIPROT:Q02153 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GUCY1B3"/> <bbox w="80.0" h="40.0" x="2070.0" y="1680.0"/> </glyph> <glyph class="macromolecule" id="s4945_sa3719" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanylate cyclase 1, soluble, alpha 3 HUGO:GUCY1A3 HGNC:4685 ENTREZ:2982 UNIPROT:Q02108 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="GUCY1A3"/> <bbox w="80.0" h="40.0" x="2070.0" y="1630.0"/> </glyph> <glyph class="simple chemical" id="s4946_sa3722" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:60837 Identifiers_end </body> </html> </notes> <label text="cGMP"/> <bbox w="70.0" h="25.0" x="1965.0" y="1347.5"/> </glyph> <glyph class="simple chemical" id="s4947_sa3723" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:71240 Identifiers_end </body> </html> </notes> <label text="Pyrophosphate"/> <bbox w="95.0" h="32.5" x="1852.5" y="1393.75"/> </glyph> <glyph class="macromolecule" id="s4949_sa3726" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neutral sphingomyelinase (N-SMase) activation associated factor HUGO:NSMAF HGNC:8017 ENTREZ:8439 UNIPROT:Q92636 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:12404124 PMID:11435466 PMID:16716889 PMID:28765050 References_end </body> </html> </notes> <label text="NSMAF"/> <bbox w="80.0" h="40.0" x="2397.5" y="1345.0"/> <glyph class="state variable" id="_3de6ca3a-511d-449f-ad21-07d83f1fa749"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2413.4314" y="1340.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s4951_sa3731" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: alkaline ceramidase 1 HUGO:ACER1 HGNC:18356 ENTREZ:125981 UNIPROT:Q8TDN7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:16716889 Nitric oxide (NO) is known to activate N-ceramidase degradation through the ubiquitine/proteasome pathway. References_end </body> </html> </notes> <label text="ACER*"/> <bbox w="80.0" h="40.0" x="2930.0" y="1780.0"/> <glyph class="state variable" id="_d8eff332-c23e-4a49-bf26-9af8dcdab8cb"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="2976.5686" y="1775.0"/> </glyph> </glyph> <glyph class="source and sink" id="s4952_sa3732" compartmentRef="c1_ca1"> <label text="s4952"/> <bbox w="30.0" h="30.0" x="3055.0" y="1785.0"/> </glyph> <glyph class="phenotype" id="s4953_sa3733" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18955971 PMID:23788428 Lysosomal membrane permeabilization in cell death. Lysosomal membrane permeabilization (LMP) causes the release of cathepsins and other hydrolases from the lysosomal lumen to the cytosol References_end </body> </html> </notes> <label text="Lysosome Membrane Permeabilization"/> <bbox w="210.0" h="25.0" x="2875.0" y="1967.5"/> </glyph> <glyph class="phenotype" id="s4954_sa3734" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12531547 The generation of a high receptor density might be required for initiation of receptor-specific signaling and explain the function of the ASM and ceramide in multiple signaling pathways. PMID:11279185 CD95-mediated clustering by ceramide is prerequisite for signaling and death References_end </body> </html> </notes> <label text="TNFR Cluster Formation"/> <bbox w="190.0" h="25.0" x="5505.0" y="207.5"/> </glyph> <glyph class="phenotype" id="s4955_sa3735" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20823910 PMID:18309324 PMID:28747251 References_end </body> </html> </notes> <label text="Ca2+ Wave"/> <clone/> <bbox w="80.0" h="30.0" x="2862.5" y="1880.0"/> </glyph> <glyph class="phenotype" id="s4955_sa3766" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20823910 PMID:18309324 PMID:28747251 References_end </body> </html> </notes> <label text="Ca2+ Wave"/> <clone/> <bbox w="80.0" h="30.0" x="6300.0" y="4335.0"/> </glyph> <glyph class="macromolecule" id="s4956_sa3736" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phospholipase A2, group IVA (cytosolic, calcium-dependent) HUGO:PLA2G4A HGNC:9035 ENTREZ:5321 UNIPROT:P47712 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: phospholipase A2, group IVA (cytosolic, calcium-dependent) References_end </body> </html> </notes> <label text="PLA2G4A"/> <bbox w="80.0" h="40.0" x="3480.0" y="1640.0"/> </glyph> <glyph class="macromolecule" id="s4957_sa3737" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phospholipase A2, group IVC (cytosolic, calcium-independent) HUGO:PLA2G4C HGNC:9037 ENTREZ:8605 UNIPROT:Q9UP65 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: phospholipase A2, group IVC (cytosolic, calcium-independent) References_end </body> </html> </notes> <label text="PLA2G4C"/> <bbox w="80.0" h="40.0" x="3480.0" y="1710.0"/> </glyph> <glyph class="simple chemical" id="s4959_sa3739" compartmentRef="c1_ca1"> <label text="Phospholipids*"/> <bbox w="115.0" h="22.5" x="3202.5" y="1768.75"/> </glyph> <glyph class="simple chemical" id="s4960_sa3740" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15843 Identifiers_end </body> </html> </notes> <label text="Arachidonic acid"/> <bbox w="115.0" h="22.5" x="3202.5" y="1878.75"/> </glyph> <glyph class="macromolecule" id="s4961_sa3741" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:23567086 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lipoxygenase homology domains 1 HUGO:LOXHD1 HGNC:26521 ENTREZ:125336 UNIPROT:Q8IVV2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Lipoxygenase*"/> <bbox w="100.0" h="30.0" x="3317.5" y="1920.0"/> </glyph> <glyph class="phenotype" id="s4962_sa3742" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:23110147 PMID:17116881 PARP1 one is able to trigger necroptosis, autophagy or apoptosis depending of cell type and state PMID:24684389 PMID:27048819 References_end </body> </html> </notes> <label text="PARP1 overactivation"/> <bbox w="167.5" h="30.0" x="1666.25" y="7725.0"/> </glyph> <glyph class="simple chemical" id="s4964_sa3745" compartmentRef="c1_ca1"> <label text="Lipid hydroperoxides"/> <bbox w="145.0" h="22.5" x="3187.5" y="1968.75"/> </glyph> <glyph class="macromolecule" id="s4965_sa3746" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arachidonate lipoxygenase 3 HUGO:ALOXE3 HGNC:13743 ENTREZ:59344 UNIPROT:Q9BYJ1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ALOXE3"/> <bbox w="80.0" h="40.0" x="3491.0" y="1830.0"/> </glyph> <glyph class="macromolecule" id="s4966_sa3747" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arachidonate 5-lipoxygenase HUGO:ALOX5 HGNC:435 ENTREZ:240 UNIPROT:P09917 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:17623009 References_end </body> </html> </notes> <label text="ALOX5"/> <bbox w="80.0" h="40.0" x="3490.0" y="1880.0"/> </glyph> <glyph class="macromolecule" id="s4967_sa3748" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arachidonate 12-lipoxygenase HUGO:ALOX12 HGNC:429 ENTREZ:239 UNIPROT:P18054 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ALOX12"/> <bbox w="80.0" h="40.0" x="3490.0" y="1930.0"/> </glyph> <glyph class="macromolecule" id="s4968_sa3749" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arachidonate 15-lipoxygenase HUGO:ALOX15 HGNC:433 ENTREZ:246 UNIPROT:P16050 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ALOX15"/> <bbox w="80.0" h="40.0" x="3490.0" y="1980.0"/> </glyph> <glyph class="macromolecule" id="s4969_sa3750" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arachidonate 12-lipoxygenase, 12R type HUGO:ALOX12B HGNC:430 ENTREZ:242 UNIPROT:O75342 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ALOX12B"/> <bbox w="80.0" h="40.0" x="3490.0" y="2030.0"/> </glyph> <glyph class="macromolecule" id="s4970_sa3751" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arachidonate 15-lipoxygenase, type B HUGO:ALOX15B HGNC:434 ENTREZ:247 UNIPROT:O15296 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ALOX15B"/> <bbox w="80.0" h="40.0" x="3340.0" y="2020.0"/> </glyph> <glyph class="macromolecule" id="s4974_sa3755" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peptidylprolyl isomerase D HUGO:PPID HGNC:9257 ENTREZ:5481 UNIPROT:Q08752 synonyms:cyclophilin D, cypD Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: peptidylprolyl isomerase D PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="PPID"/> <bbox w="80.0" h="40.0" x="5960.0" y="3850.0"/> </glyph> <glyph class="simple chemical" id="s4996_sa161" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17976 KEGGCOMPOUND:C00390 Identifiers_end </body> </html> </notes> <label text="ubiquinol"/> <bbox w="70.0" h="25.0" x="1426.2369" y="5270.75"/> </glyph> <glyph class="simple chemical" id="s4997_sa162" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:27186 Identifiers_end References_begin: synonym:mitochondrial ubiquinones CHEBI definition: Naturally occurring lipid-soluble benzoquinones that are involved in electron transport in mitochondria. The polyprenyl chain consists of 6 to 12 isoprenoid units. References_end </body> </html> </notes> <label text="ubiquinone"/> <clone/> <bbox w="70.0" h="25.0" x="1255.2369" y="5272.75"/> </glyph> <glyph class="simple chemical" id="s4997_sa385" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:27186 Identifiers_end References_begin: synonym:mitochondrial ubiquinones CHEBI definition: Naturally occurring lipid-soluble benzoquinones that are involved in electron transport in mitochondria. The polyprenyl chain consists of 6 to 12 isoprenoid units. References_end </body> </html> </notes> <label text="ubiquinone"/> <clone/> <bbox w="70.0" h="25.0" x="1981.75" y="5272.5"/> </glyph> <glyph class="simple chemical" id="s5012_sa3774" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:37624 Identifiers_end References_begin: PMID:22248338 References_end </body> </html> </notes> <label text="Glucose-1P"/> <bbox w="77.5" h="27.5" x="480.0" y="820.0"/> </glyph> <glyph class="macromolecule" id="s5013_sa3775" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglucomutase 1 HUGO:PGM1 HGNC:8905 ENTREZ:5236 UNIPROT:P36871 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18651836 PMID:18149991 References_end </body> </html> </notes> <label text="PGM1"/> <bbox w="80.0" h="40.0" x="300.0" y="890.0"/> </glyph> <glyph class="macromolecule" id="s5014_sa3776" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglucomutase 2 HUGO:PGM2 HGNC:8906 ENTREZ:55276 UNIPROT:Q96G03 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18149991 References_end </body> </html> </notes> <label text="PGM2"/> <bbox w="80.0" h="40.0" x="490.0" y="960.0"/> </glyph> <glyph class="macromolecule" id="s5015_sa3777" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglucomutase 3 HUGO:PGM3 HGNC:8907 ENTREZ:5238 UNIPROT:O95394 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18149991 References_end </body> </html> </notes> <label text="PGM3"/> <bbox w="80.0" h="40.0" x="300.0" y="960.0"/> </glyph> <glyph class="macromolecule" id="s5016_sa3778" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglucomutase 5 HUGO:PGM5 HGNC:8908 ENTREZ:5239 UNIPROT:Q15124 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18149991 References_end </body> </html> </notes> <label text="PGM5"/> <bbox w="80.0" h="40.0" x="400.0" y="960.0"/> </glyph> <glyph class="macromolecule" id="s5017_sa3779" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18651836 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoglucomutase 1 HUGO:PGM1 HGNC:8905 ENTREZ:5236 UNIPROT:P36871 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: Phosphoglucomutase PMID:18651836 References_end </body> </html> </notes> <label text="PGM*"/> <bbox w="80.0" h="40.0" x="440.0" y="890.0"/> </glyph> <glyph class="simple chemical" id="s5018_sa3780" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28087 Identifiers_end References_begin: PMID:22248338 References_end </body> </html> </notes> <label text="Glycogen"/> <bbox w="70.0" h="25.0" x="485.0" y="717.5"/> </glyph> <glyph class="simple chemical" id="s5047_sa861" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="1100.0" y="1472.5"/> </glyph> <glyph class="simple chemical" id="s5047_sa901" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="1192.2163" y="2428.399"/> </glyph> <glyph class="simple chemical" id="s5047_sa5352" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS MODULE:GLUCOSE_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="8550.0" y="1236.25"/> </glyph> <glyph class="simple chemical" id="s5049_sa3784" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17158 Identifiers_end References_begin: PMID:20823910 PMID:11792832 Methylglyoxal covalently binds to proteins and forms advanced glycation end products (AGEs), which alter protein function and constitute new centres of sustained ROS generation References_end </body> </html> </notes> <label text="Methylglyoxal"/> <bbox w="95.0" h="42.5" x="1427.5" y="1215.0"/> </glyph> <glyph class="simple chemical" id="s5050_sa3785" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18367 Identifiers_end </body> </html> </notes> <label text="Orthophosphate"/> <bbox w="105.0" h="22.5" x="1407.5" y="1282.5"/> </glyph> <glyph class="macromolecule" id="s5051_sa3787" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: EC 4.2.3.3 PMID:11945504 References_end </body> </html> </notes> <label text="methylglyoxal synthase"/> <bbox w="160.0" h="30.0" x="1350.0" y="1165.0"/> </glyph> <glyph class="phenotype" id="s5052_sa3789" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Advanced Glycation End products PMID:23769884 PMID:20823910 PMID:11792832 Methylglyoxal covalently binds to proteins and forms advanced glycation end products (AGEs), which alter protein function and constitute new centres of sustained ROS generation References_end </body> </html> </notes> <label text="AGEs"/> <bbox w="80.0" h="30.0" x="1592.5" y="1220.0"/> </glyph> <glyph class="simple chemical" id="s5053_sa3791" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="DNA alkylating agents"/> <bbox w="142.5" h="30.0" x="1718.75" y="7635.0"/> <glyph class="unit of information" id="_e212871f-351e-4cbf-b00c-29e60411ed03"> <label text="drug"/> <bbox w="25.0" h="10.0" x="1777.5" y="7630.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5058_sa3796" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin B HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end References_begin: synonym:cathepsins References_end </body> </html> </notes> <label text="CTSB"/> <bbox w="80.0" h="40.0" x="3210.0" y="2350.0"/> <glyph class="state variable" 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="2110.0" y="6280.0"/> <glyph class="state variable" id="_302f0b88-015e-4a9f-adea-6bd0a331efce"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="2143.938" y="6275.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s5067_sa3802" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16240 Identifiers_end References_begin: PMID:18955971 References_end </body> </html> </notes> <label text="H2O2"/> <bbox w="125.0" h="22.5" x="2917.5" y="2188.75"/> </glyph> <glyph class="simple chemical" id="s5068_sa3803" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18955971 References_end </body> </html> </notes> <label text="Hydroxyl radical"/> <bbox w="125.0" h="20.0" x="2917.5" y="2121.25"/> </glyph> <glyph class="macromolecule" id="s5070_sa3805" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="3130.0" y="2140.0"/> <glyph class="state variable" id="_7da56af9-63b3-4d4c-9b2a-56c12314fb47"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="3131.0771" y="2135.0"/> </glyph> <glyph class="state variable" id="_be5aa0d0-5d11-4158-a759-afe711a7693c"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="3176.0845" y="2135.0"/> </glyph> <glyph class="state variable" id="_8af9dbde-928e-4d08-aa4e-04b6ac8be081"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="3176.321" y="2175.0"/> </glyph> </glyph> <glyph class="phenotype" id="s5071_sa3807" compartmentRef="c4_ca4"> <label text="ROS production"/> <bbox w="110.0" h="25.0" x="5165.0" y="6162.5"/> </glyph> <glyph class="simple chemical" id="s5072_sa3808" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PUBCHEM:2973 Identifiers_end References_begin: CID 2973 PMID:23788428 iron chelator PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Deferoxamine"/> <clone/> <bbox w="100.0" h="25.0" x="2880.0" y="1607.5"/> <glyph class="unit of information" id="_cfcdf7fd-9fed-4550-894d-3f565b77ac7b"> <label text="drug"/> <bbox w="25.0" h="10.0" x="2917.5" y="1602.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s5072_sa5273" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PUBCHEM:2973 Identifiers_end References_begin: CID 2973 PMID:23788428 iron chelator PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Deferoxamine"/> <clone/> <bbox w="80.0" h="30.0" x="9830.0" y="315.0"/> <glyph class="unit of information" id="_aae3c871-e29e-4523-aa19-d2f3e1fe4e51"> <label text="drug"/> <bbox w="25.0" h="10.0" x="9857.5" y="310.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5073_sa3809" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="6110.0" y="125.0"/> </glyph> <glyph class="macromolecule" id="s5074_sa3823" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor receptor superfamily, member 10a HUGO:TNFRSF10A HGNC:11904 ENTREZ:8797 UNIPROT:O00220 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 Also known as DR4, TRAILR1 References_end </body> </html> </notes> <label text="TNFRSF10A"/> <bbox w="80.0" h="50.0" x="6340.0" y="235.0"/> <glyph class="unit of information" id="_5a7c6a46-045a-498a-a26b-04d4f7d232db"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6357.5" y="230.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5075_sa3824" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor receptor superfamily, member 10b HUGO:TNFRSF10B HGNC:11905 ENTREZ:8795 UNIPROT:O14763 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:20531300 Also known as DR5, TRAILR2 References_end </body> </html> </notes> <label text="TNFRSF10B"/> <bbox w="80.0" h="50.0" x="6340.0" y="175.0"/> <glyph class="unit of information" id="_51ccac83-704b-408a-b84a-77568bcafae3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6357.5" y="170.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5076_sa3812" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain HUGO:TNFRSF10C HGNC:11906 ENTREZ:8794 UNIPROT:O14798 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242611 DcR1 acted as a decoy receptor that inhibited TRAIL signaling References_end </body> </html> </notes> <label text="TNFRSF10C"/> <bbox w="80.0" h="50.0" x="6050.0" y="200.0"/> <glyph class="unit of information" id="_7f8a3fdd-b57d-4d79-a19a-4d7334d0a12a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6067.5" y="195.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5077_sa3820" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain HUGO:TNFRSF10D HGNC:11907 ENTREZ:8793 UNIPROT:Q9UBN6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9603945 Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL Also known as DcR2 (for Decoy Receptor 2) PMID:9382840 References_end </body> </html> </notes> <label text="TNFRSF10D"/> <bbox w="80.0" h="50.0" x="6140.0" y="200.0"/> <glyph class="unit of information" id="_2d696326-0812-473b-9331-76acaa865f8d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6157.5" y="195.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5078_sa3814" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor receptor superfamily, member 11b HUGO:TNFRSF11B HGNC:11909 ENTREZ:4982 UNIPROT:O00300 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: tumor necrosis factor receptor superfamily, member 11b PMID:20531300 Also known as osteoprotegrin, OPG References_end </body> </html> </notes> <label text="TNFRSF11B"/> <bbox w="80.0" h="40.0" x="5830.0" y="220.0"/> </glyph> <glyph class="complex" id="s5081_csa383" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNFRSF11B:TRAIL* Identifiers_end </body> </html> </notes> <label text="s5081"/> <bbox w="100.0" h="120.0" x="5710.0" y="140.0"/> <glyph class="macromolecule" id="s5082_sa3815"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="5720.0" y="150.0"/> </glyph> <glyph class="macromolecule" id="s5083_sa3816"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor receptor superfamily, member 11b HUGO:TNFRSF11B HGNC:11909 ENTREZ:4982 UNIPROT:O00300 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: tumor necrosis factor receptor superfamily, member 11b PMID:20531300 Also known as osteoprotegrin, OPG References_end </body> </html> </notes> <label text="TNFRSF11B"/> <bbox w="80.0" h="40.0" x="5720.0" y="190.0"/> </glyph> </glyph> <glyph class="complex" id="s5087_csa384" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNFRSF10C:TRAIL* Identifiers_end References_begin: 9242611 DcR1 acted as a decoy receptor that inhibited TRAIL signaling References_end </body> </html> </notes> <label text="TRAIL*:TNFRSF10C"/> <bbox w="100.0" h="120.0" x="5930.0" y="140.0"/> <glyph class="macromolecule" id="s5088_sa3817"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain HUGO:TNFRSF10C HGNC:11906 ENTREZ:8794 UNIPROT:O14798 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242611 DcR1 acted as a decoy receptor that inhibited TRAIL signaling References_end </body> </html> </notes> <label text="TNFRSF10C"/> <bbox w="80.0" h="50.0" x="5940.0" y="195.0"/> <glyph class="unit of information" id="_c08d6881-5958-4345-89c9-33f329d137bb"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="5957.5" y="190.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5086_sa3819"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="5940.0" y="150.0"/> </glyph> </glyph> <glyph class="complex" id="s5093_csa385" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNFRSF10D:TRAIL* Identifiers_end References_begin: 9603945 Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL 9382840 References_end </body> </html> </notes> <label text="TRAIL*:TNFRSF10D"/> <bbox w="100.0" h="130.0" x="6230.0" y="125.0"/> <glyph class="macromolecule" id="s5097_sa3813"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain HUGO:TNFRSF10D HGNC:11907 ENTREZ:8793 UNIPROT:Q9UBN6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9603945 Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL Also known as DcR2 (for Decoy Receptor 2) PMID:9382840 References_end </body> </html> </notes> <label text="TNFRSF10D"/> <bbox w="80.0" h="50.0" x="6240.0" y="180.0"/> <glyph class="unit of information" id="_9d3e4755-08cf-441c-bbbc-d975ce2f6927"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6257.5" y="175.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5096_sa3818"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="6240.0" y="135.0"/> </glyph> </glyph> <glyph class="complex" id="s5103_csa388" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DR4/5*:TRAIL* Identifiers_end References_begin: TRAIL*:DR4/5* References_end </body> </html> </notes> <label text="TRAIL*/DR4/5*"/> <bbox w="100.0" h="132.5" x="6570.0" y="137.5"/> <glyph class="macromolecule" id="s5107_sa3828"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="6580.0" y="147.5"/> </glyph> <glyph class="macromolecule" id="s5108_sa3829"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="6580.0" y="192.5"/> <glyph class="state variable" id="_52069d1e-c5e2-4179-8d5a-6f90bff92ae7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6615.0" y="237.5"/> </glyph> <glyph class="state variable" id="_3a17c86e-01fd-4ea4-9fc5-ad45180866f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6655.0" y="212.5"/> </glyph> <glyph class="unit of information" id="_a1ba82e0-32b6-4955-a9be-d12df30aab8e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6597.5" y="187.5"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s5104_sa3827" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="6470.0" y="195.0"/> <glyph class="state variable" id="_f37a1ac2-4f05-4de3-a51b-016aa70ad01b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6505.0" y="240.0"/> </glyph> <glyph class="state variable" id="_11eed89d-e178-4474-8997-c7c757569be0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6545.0" y="215.0"/> </glyph> <glyph class="unit of information" id="_50374b88-997f-416a-b562-0f3f500cfaef"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6487.5" y="190.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5112_sa3841" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) HUGO:GALNT14 HGNC:22946 ENTREZ:79623 UNIPROT:Q96FL9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 24 peptidyl GalNAc transferase(GALNT) isoforms activation lead to trimerization of DR4/5 receptors References_end </body> </html> </notes> <label text="GALNT14"/> <bbox w="80.0" h="40.0" x="6670.0" y="310.0"/> </glyph> <glyph class="macromolecule" id="s5126_sa3858" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 10, apoptosis-related cysteine peptidase HUGO:CASP10 HGNC:1500 ENTREZ:843 UNIPROT:Q92851 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: caspase 10, apoptosis-related cysteine peptidase (CASP10) PMID:20531300 References_end </body> </html> </notes> <label text="Caspase10*"/> <clone/> <bbox w="80.0" h="40.0" x="6790.0" y="390.0"/> </glyph> <glyph class="macromolecule" id="s5126_sa4455" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 10, apoptosis-related cysteine peptidase HUGO:CASP10 HGNC:1500 ENTREZ:843 UNIPROT:Q92851 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: caspase 10, apoptosis-related cysteine peptidase (CASP10) PMID:20531300 References_end </body> </html> </notes> <label text="Caspase10*"/> <clone/> <bbox w="80.0" h="40.0" x="7045.5" y="1060.0"/> </glyph> <glyph class="macromolecule" id="s5126_sa4645" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 10, apoptosis-related cysteine peptidase HUGO:CASP10 HGNC:1500 ENTREZ:843 UNIPROT:Q92851 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: caspase 10, apoptosis-related cysteine peptidase (CASP10) PMID:20531300 References_end </body> </html> </notes> <label text="Caspase10*"/> <clone/> <bbox w="80.0" h="40.0" x="4498.0" y="6896.87"/> </glyph> <glyph class="complex" id="s5142_csa389" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DR4/5*:FADD:TRAIL* Identifiers_end References_begin: 20531300 19090789 8777713 8663110 TRAIL*:DR4/5*:FADD 17914579 Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling 17767167 References_end </body> </html> </notes> <label text="DR4/5*:FADD:TRAIL*"/> <bbox w="210.0" h="147.5" x="6735.0" y="126.25"/> <glyph class="macromolecule" id="s5143_sa3845"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="6835.0" y="133.75"/> </glyph> <glyph class="macromolecule" id="s5144_sa3846"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="6835.0" y="178.75"/> <glyph class="state variable" id="_5318998e-c722-43f7-b6d6-c92654444112"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="6865.0" y="223.75"/> </glyph> <glyph class="state variable" id="_9c887caf-18b0-40fb-9520-3216fbd9f747"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="6907.5" y="198.75"/> </glyph> <glyph class="unit of information" id="_a5aa2523-75f3-4684-8931-d61131893b0c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6852.5" y="173.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5145_sa3847"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="6755.0" y="178.75"/> </glyph> <glyph class="macromolecule" id="s5143_sa3848"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="6845.0" y="143.75"/> </glyph> <glyph class="macromolecule" id="s5144_sa3849"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="6845.0" y="188.75"/> <glyph class="state variable" id="_dde925e5-7010-4a1b-8301-b0276997545f"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="6875.0" y="233.75"/> </glyph> <glyph class="state variable" id="_561a23c4-b4ea-48b8-a996-84e52d65ce46"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="6917.5" y="208.75"/> </glyph> <glyph class="unit of information" id="_e5a64ee4-be0b-434b-ae45-03fd00d7f072"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6862.5" y="183.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5145_sa3850"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="6765.0" y="188.75"/> </glyph> <glyph class="macromolecule" id="s5143_sa3851"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="6855.0" y="153.75"/> </glyph> <glyph class="macromolecule" id="s5144_sa3852"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="6855.0" y="198.75"/> <glyph class="state variable" id="_e1e9c4d9-198c-43f9-bf97-592fed5b956a"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="6885.0" y="243.75"/> </glyph> <glyph class="state variable" id="_b092d4e1-52bc-487a-8627-d96d65cec039"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="6927.5" y="218.75"/> </glyph> <glyph class="unit of information" id="_11f06524-bfc9-4da1-85be-82175b29dc4c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6872.5" y="193.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5145_sa3853"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="6775.0" y="198.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5146_sa3873" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="6950.0" y="490.0"/> </glyph> <glyph class="macromolecule" id="s5147_sa3874" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="6950.0" y="550.0"/> </glyph> <glyph class="macromolecule" id="s5150_sa3878" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <clone/> <bbox w="80.0" h="40.0" x="7260.0" y="480.0"/> <glyph class="state variable" id="_b13587db-7680-4763-8e12-142c91c111c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7278.4316" y="475.0"/> </glyph> <glyph class="state variable" id="_f562bae7-62b8-47e1-b7f7-cf256a16ebe0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7311.5684" y="475.0"/> </glyph> <glyph class="state variable" id="_0a334fed-277a-4c62-a049-a240c790b602"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7295.0" y="515.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5150_sa4247" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <clone/> <bbox w="80.0" h="40.0" x="3900.0" y="600.0"/> <glyph class="state variable" id="_ffaeea23-926f-407f-8698-94b3e7fe33f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3918.4314" y="595.0"/> </glyph> <glyph class="state variable" id="_86f9e57d-25c4-482c-a61b-f4b4bd372403"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3951.5686" y="595.0"/> </glyph> <glyph class="state variable" id="_92c58a09-5dfa-49f6-91ee-7427e6c93a4b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3935.0" y="635.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5150_sa4445" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <clone/> <bbox w="80.0" h="40.0" x="11622.0" y="2584.5"/> <glyph class="state variable" id="_9f4e07aa-2b13-4da0-b4ed-07d1a7fa20fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11640.432" y="2579.5"/> </glyph> <glyph class="state variable" id="_ccb1e218-a5ad-4241-a531-28d807e976fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11673.568" y="2579.5"/> </glyph> <glyph class="state variable" id="_095fea6f-59a4-4010-a8aa-ce5fe868d8a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11657.0" y="2619.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s5150_sa5279" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <clone/> <bbox w="80.0" h="40.0" x="9420.0" y="1210.0"/> <glyph class="state variable" id="_47244fb6-034b-41ca-accb-fc8c298b808f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9438.432" y="1205.0"/> </glyph> <glyph class="state variable" id="_22123e99-da31-4079-ba24-4543a30eae97"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9471.568" y="1205.0"/> </glyph> <glyph class="state variable" id="_2f1dfceb-8ab9-47cf-b716-145af9bcaeef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9455.0" y="1245.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5185_sa3918" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22427918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 References_end </body> </html> </notes> <label text="cleaved Caspase 10*"/> <clone/> <bbox w="80.0" h="40.0" x="6920.0" y="1050.0"/> <glyph class="unit of information" id="_c6b0fe9d-3757-48e1-9a24-3a4f5f464ede"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6935.0" y="1045.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5185_sa3920" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22427918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 References_end </body> </html> </notes> <label text="cleaved Caspase 10*"/> <clone/> <bbox w="80.0" h="40.0" x="7370.0" y="4400.0"/> <glyph class="unit of information" id="_9e37e82c-a6a1-42ad-9f5b-33c99a93c348"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7385.0" y="4395.0"/> </glyph> </glyph> <glyph class="complex" id="s5186_csa395" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase10*:Caspase8*:FADD:IKBKG:RIPK1:TRADD:TRAF2 Identifiers_end References_begin: TRAF2:TRADD:FADD:Caspase8*:Caspase10*:IKBKG:RIPKA 20531300 The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase 10958661 23845861 21822306 NF-κB exerts a pro-apoptotic role in TRAIL- and CD95-induced apoptosis in glioblastoma cells by facilitating DISC formation References_end </body> </html> </notes> <label text="TRAIL Complex II"/> <bbox w="210.0" h="217.5" x="6575.0" y="711.25"/> <glyph class="macromolecule" id="s5187_sa3921"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="6595.0" y="786.25"/> </glyph> <glyph class="macromolecule" id="s5188_sa3922"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TRADD"/> <bbox w="80.0" h="40.0" x="6595.0" y="746.25"/> </glyph> <glyph class="macromolecule" id="s5189_sa3923"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28462525 References_end </body> </html> </notes> <label text="Caspase8*"/> <bbox w="80.0" h="40.0" x="6595.0" y="826.25"/> <glyph class="state variable" id="_8f03e6ad-084c-403c-866f-2d6ac616de33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6590.0" y="832.9657"/> </glyph> </glyph> <glyph class="macromolecule" id="s5190_sa3924"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 10, apoptosis-related cysteine peptidase HUGO:CASP10 HGNC:1500 ENTREZ:843 UNIPROT:Q92851 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: caspase 10, apoptosis-related cysteine peptidase (CASP10) PMID:20531300 References_end </body> </html> </notes> <label text="Caspase10*"/> <bbox w="80.0" h="40.0" x="6595.0" y="866.25"/> </glyph> <glyph class="macromolecule" id="s5191_sa3925"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="6695.0" y="786.25"/> <glyph class="state variable" id="_1d384afc-7ba1-42e6-b0b9-aac412cdcd00"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6690.0" y="792.42114"/> </glyph> <glyph class="state variable" id="_a6438a04-53fa-4c64-903f-f2f32efcaf70"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="6760.0" y="792.5"/> </glyph> <glyph class="state variable" id="_f561a941-b023-42f8-8750-199d37dfcc7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6732.8364" y="781.25"/> </glyph> <glyph class="state variable" id="_a841fdda-eaf6-438b-a939-9b62bd43d3da"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="6736.3306" y="821.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5192_sa3926"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <bbox w="80.0" h="40.0" x="6675.0" y="726.25"/> </glyph> <glyph class="macromolecule" id="s5193_sa3927"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <bbox w="80.0" h="40.0" x="6675.0" y="836.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5202_sa3942" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: XIAP associated factor 1 HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="XAF1"/> <bbox w="80.0" h="40.0" x="5553.0" y="575.75"/> </glyph> <glyph class="complex" id="s5203_csa396" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:XAF1:cIAP* Identifiers_end </body> </html> </notes> <label text="cIAP*:XAF1"/> <bbox w="100.0" h="120.0" x="5545.5" y="680.25"/> <glyph class="macromolecule" id="s5205_sa3941"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: XIAP associated factor 1 HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="XAF1"/> <bbox w="80.0" h="40.0" x="5555.5" y="690.25"/> </glyph> <glyph class="macromolecule" id="s5204_sa3943"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytokine induced apoptosis inhibitor 1 HUGO:CIAPIN1 HGNC:28050 ENTREZ:57019 UNIPROT:Q6FI81 baculoviral IAP repeat containing 2 HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490 baculoviral IAP repeat containing 3 HUGO:BIRC3 HGNC:591 ENTREZ:330 UNIPROT:Q13489 Identifiers_end Maps_Modules_begin: MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="cIAP*"/> <bbox w="80.0" h="40.0" x="5555.5" y="730.25"/> <glyph class="state variable" id="_b1cbbe86-3ba2-404b-8548-01bc53fba9ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5607.0684" y="725.25"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s5206_sa3944" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: XIAP associated factor 1 HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="XAF1"/> <bbox w="80.0" h="40.0" x="7130.0" y="2970.0"/> </glyph> <glyph class="complex" id="s5207_csa397" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:XAF1:XIAP Identifiers_end References_begin: 23070005 References_end </body> </html> </notes> <label text="XAF1:XIAP"/> <bbox w="100.0" h="120.0" x="6922.5" y="2875.0"/> <glyph class="macromolecule" id="s5209_sa3945"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: XIAP associated factor 1 HUGO:XAF1 HGNC:30932 ENTREZ:54739 UNIPROT:Q6GPH4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:23070005 References_end </body> </html> </notes> <label text="XAF1"/> <bbox w="80.0" h="40.0" x="6932.5" y="2885.0"/> </glyph> <glyph class="macromolecule" id="s5208_sa3946"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="6932.5" y="2925.0"/> <glyph class="state variable" id="_644628bf-ffd9-414b-bd5d-26f653380449"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6950.9316" y="2920.0"/> </glyph> <glyph class="state variable" id="_4d8ab8af-188b-4d86-9deb-3cb0649b614a"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="6976.949" y="2920.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5213_csa399" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase7*:XIAP Identifiers_end </body> </html> </notes> <label text="Caspase7*:XIAP"/> <bbox w="100.0" h="120.0" x="7118.666" y="4527.7236"/> <glyph class="macromolecule" id="s5214_sa3951"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="7128.666" y="4537.7236"/> <glyph class="state variable" id="_e368337e-aac5-4e49-8816-c600cf9fed02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7147.0977" y="4532.7236"/> </glyph> <glyph class="state variable" id="_c82f43ea-5bc4-4dfc-baa3-702efc55cc30"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7170.615" y="4532.7236"/> </glyph> </glyph> <glyph class="macromolecule" id="s5215_sa3953"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 7, apoptosis-related cysteine peptidase HUGO:CASP7 HGNC:1508 ENTREZ:840 UNIPROT:P55210 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Caspase7*"/> <bbox w="80.0" h="40.0" x="7128.666" y="4577.7236"/> </glyph> </glyph> <glyph class="complex" id="s5216_csa400" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase3*:XIAP Identifiers_end </body> </html> </notes> <label text="Caspase3*:XIAP"/> <bbox w="97.5" h="110.0" x="6942.5" y="4120.0"/> <glyph class="macromolecule" id="s5217_sa3947"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="6952.5" y="4130.0"/> <glyph class="state variable" id="_d77d0488-0557-4017-8029-184bd4c96640"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6970.9316" y="4125.0"/> </glyph> <glyph class="state variable" id="_25853c0d-b136-4908-ad12-e5c19db7e238"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="6994.449" y="4125.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5218_sa3954"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <bbox w="80.0" h="40.0" x="6952.5" y="4170.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5223_sa3957" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="5763.0" y="580.25"/> <glyph class="state variable" id="_efad3489-0db4-4ac5-9793-9e6b6792a8d8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5781.4316" y="575.25"/> </glyph> <glyph class="state variable" id="_9af98086-dc0f-4f3d-a7a3-dfe11c52bc5a"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="5807.449" y="575.25"/> </glyph> </glyph> <glyph class="complex" id="s5224_csa401" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB*:TAK1*:XIAP Identifiers_end References_begin: 23070005 References_end </body> </html> </notes> <label text="TAB*:TAK1:XIAP"/> <bbox w="100.0" h="172.5" x="5755.5" y="690.25"/> <glyph class="macromolecule" id="s5225_sa3956"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="5765.5" y="752.75"/> <glyph class="state variable" id="_ad8e3c98-af45-4dd4-af97-497bbf3f3a41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5783.9316" y="747.75"/> </glyph> <glyph class="state variable" id="_8df2448f-7223-41a4-a370-7b2054de45a5"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="5809.949" y="747.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5227_sa3958"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 TGF-beta activated kinase 1/MAP3K7 binding protein 3 HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="TAB*"/> <bbox w="80.0" h="40.0" x="5765.5" y="700.25"/> </glyph> <glyph class="macromolecule" id="s5226_sa3959"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: synonym:TAK1 PMID:23070005 References_end </body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="5765.5" y="802.75"/> <glyph class="state variable" id="_a51e3a49-99d1-447f-af12-a5fb208bf945"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5807.0684" y="797.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5229_csa402" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN1:Ca2+ Identifiers_end </body> </html> </notes> <label text="Calpain activated"/> <bbox w="100.0" h="100.0" x="6222.5" y="4405.0"/> <glyph class="simple chemical" id="s5231_sa3961"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end Maps_Modules_begin: MODULE:AKT_MTOR Maps_Modules_end </body> </html> </notes> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="6277.5" y="4417.5"/> </glyph> <glyph class="macromolecule" id="s5234_sa3965"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <bbox w="80.0" h="40.0" x="6230.0" y="4440.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5232_sa3962" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="80.0" h="40.0" x="6380.0" y="4480.0"/> </glyph> <glyph class="macromolecule" id="s5232_sa5068" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="80.0" h="40.0" x="8790.0" y="3850.0"/> </glyph> <glyph class="macromolecule" id="s5235_sa3964" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <bbox w="80.0" h="40.0" x="5810.0" y="4730.0"/> <glyph class="state variable" id="_fc7eef6e-3cf6-46c6-b17b-1741c0d9432b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5861.5684" y="4725.0"/> </glyph> <glyph class="unit of information" id="_8358ed30-60e8-4d86-926c-c4a71d74e26f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5825.0" y="4725.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5236_sa3968" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:22581845 References_end </body> </html> </notes> <label text="cleaved BAX*"/> <bbox w="80.0" h="40.0" x="5760.0" y="2670.0"/> <glyph class="unit of information" id="_40dd7b0f-17bf-46c3-9ce4-bf0fa773f72d"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5775.0" y="2665.0"/> </glyph> </glyph> <glyph class="source and sink" id="s5240_sa3971" compartmentRef="c1_ca1"> <label text="s5240"/> <bbox w="30.0" h="30.0" x="6245.0" y="3795.0"/> </glyph> <glyph class="source and sink" id="s5242_sa3977" compartmentRef="c1_ca1"> <label text="s5242"/> <bbox w="30.0" h="30.0" x="4885.0" y="3585.0"/> </glyph> <glyph class="macromolecule" id="s5250_sa3987" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12702723 FAF1 is a member of Fas-DISC acting upstream of caspase-8 PMID:19597341 FAF1 downregulation may contribute to multiple aspects of tumorigenesis References_end </body> </html> </notes> <label text="FAF1"/> <clone/> <bbox w="80.0" h="40.0" x="8250.0" y="410.0"/> </glyph> <glyph class="macromolecule" id="s5250_sa4669" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12702723 FAF1 is a member of Fas-DISC acting upstream of caspase-8 PMID:19597341 FAF1 downregulation may contribute to multiple aspects of tumorigenesis References_end </body> </html> </notes> <label text="FAF1"/> <clone/> <bbox w="80.0" h="40.0" x="4679.0" y="6927.0"/> </glyph> <glyph class="macromolecule" id="s5251_sa3990" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11003656 References_end </body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="7662.0" y="7919.0"/> </glyph> <glyph class="complex" id="s5253_csa408" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAXX:HSPB1 Identifiers_end </body> </html> </notes> <label text="DAXX:HSPB1"/> <bbox w="100.0" h="120.0" x="7492.5" y="7915.0"/> <glyph class="macromolecule" id="s5254_sa3991"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11003656 References_end </body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="7502.0" y="7929.0"/> </glyph> <glyph class="macromolecule" id="s5255_sa3992"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock 27kDa protein 1 HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:HSP27PMID:11003656 References_end </body> </html> </notes> <label text="HSPB1"/> <bbox w="80.0" h="40.0" x="7502.5" y="7975.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5257_sa3994" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) HUGO:PTPN13 HGNC:9646 ENTREZ:5783 UNIPROT:Q12923 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:12724420 FAP-1 (also known as PTPN13) association with Fas (Apo-1) inhibits Fas expression on the cell surface References_end </body> </html> </notes> <label text="PTPN13"/> <bbox w="80.0" h="40.0" x="7970.0" y="350.0"/> </glyph> <glyph class="macromolecule" id="s5258_sa4009" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8 associated protein 2 HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival PMID:12702723 PMID:15592525 PMID:1134007 References_end </body> </html> </notes> <label text="FLASH*"/> <bbox w="80.0" h="40.0" x="7660.0" y="750.0"/> </glyph> <glyph class="complex" id="s5261_csa409" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAS:FASLG Identifiers_end References_begin: 22075988 References_end </body> </html> </notes> <label text="FAS:FASLG"/> <bbox w="100.0" h="130.0" x="8130.0" y="145.0"/> <glyph class="macromolecule" id="s5263_sa4000"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="8140.0" y="200.0"/> <glyph class="state variable" id="_7f9666c1-66b4-4eff-8f33-feca881de7e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8215.0" y="209.64465"/> </glyph> <glyph class="unit of information" id="_6f028999-dee7-4817-b782-7f811766bc50"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8157.5" y="195.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5262_sa4050"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="8140.0" y="155.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5264_sa4001" compartmentRef="c32_ca33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7840.0" y="375.0"/> <glyph class="state variable" id="_a08e4a88-9ac0-46ef-9b3e-69256356aafc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7915.0" y="384.64465"/> </glyph> <glyph class="unit of information" id="_88e7bfcc-ae01-4a01-9c99-298dd217b705"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7857.5" y="370.0"/> </glyph> </glyph> <glyph class="complex" id="s5265_csa410" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAS:FASLG Identifiers_end </body> </html> </notes> <label text="FAS:FASLG:FADD:DAXX:ASK1"/> <bbox w="130.0" h="150.0" x="8295.0" y="135.0"/> <glyph class="macromolecule" id="s5351_sa3999"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="8323.0" y="176.0"/> </glyph> <glyph class="macromolecule" id="s6070_sa4049"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="8322.0" y="216.0"/> <glyph class="state variable" id="_57c697e7-1ecb-4056-b19a-dd01bd9fd2a9"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="8392.0" y="225.64465"/> </glyph> <glyph class="unit of information" id="_98ef10fd-336a-4b16-86fe-983a14528f66"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8339.5" y="211.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s6070_sa4051"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="8312.0" y="206.0"/> <glyph class="state variable" id="_29481cfb-147c-4e41-ab9b-5dfb0fa3b2ae"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="8382.0" y="215.64465"/> </glyph> <glyph class="unit of information" id="_8f38c952-3dd6-4658-83c8-d6674969d96d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8329.5" y="201.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5351_sa4052"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="8315.0" y="165.0"/> </glyph> <glyph class="macromolecule" id="s6070_sa4053"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="8302.0" y="196.0"/> <glyph class="state variable" id="_b5783d17-48e2-40c1-92fa-5f0cd936ac6b"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="8372.0" y="205.64465"/> </glyph> <glyph class="unit of information" id="_ca978eac-adaf-4cfe-8cba-cb49b223e132"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8319.5" y="191.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5351_sa4054"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="8305.0" y="155.0"/> </glyph> </glyph> <glyph class="complex" id="s5305_csa413" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase8,10*:FLASH* Identifiers_end References_begin: 22427918 caspase-8 formed triple complex with TRAF2 and FLASH. Taken together, these results suggest that endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH References_end </body> </html> </notes> <label text="Caspase8,10*:FLASH"/> <bbox w="140.0" h="120.0" x="7690.0" y="570.0"/> <glyph class="macromolecule" id="s5307_sa3988"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7702.5" y="625.0"/> <glyph class="state variable" id="_692e3e68-2283-4527-9a44-bc2c6dce7209"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7697.5" y="631.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="s5306_sa3995"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 associated protein 2 HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival PMID:12702723 PMID:15592525 PMID:1134007 References_end </body> </html> </notes> <label text="FLASH*"/> <bbox w="80.0" h="40.0" x="7720.0" y="580.0"/> </glyph> </glyph> <glyph class="complex" id="s5353_csa411" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase8,10*:DAXX:FADD:FAF1:FAS:FASLG:FLASH*:RIPK1 Identifiers_end References_begin: 10*:FLASH*:RIPK1:FAF1:FADD:DAXX:FASLG:FAS Apoptosis complex led by FAS ligation 12702723 9184224 23069999 16498403 the subcellular localization and internalization pathways of CD95 play important roles in controlling activation of distinct signaling cascades to determine divergent cellular fates References_end </body> </html> </notes> <label text="FAS DISC"/> <bbox w="406.25" h="190.0" x="7587.0" y="875.25"/> <glyph class="macromolecule" id="s5299_sa4004"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7793.25" y="945.25"/> </glyph> <glyph class="macromolecule" id="s5300_sa4005"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11003656 References_end </body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="7793.25" y="995.25"/> </glyph> <glyph class="macromolecule" id="s5303_sa4019"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12702723 FAF1 is a member of Fas-DISC acting upstream of caspase-8 PMID:19597341 FAF1 downregulation may contribute to multiple aspects of tumorigenesis References_end </body> </html> </notes> <label text="FAF1"/> <bbox w="80.0" h="40.0" x="7797.0" y="892.75"/> </glyph> <glyph class="macromolecule" id="s5304_sa4020"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 associated protein 2 HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival PMID:12702723 PMID:15592525 PMID:1134007 References_end </body> </html> </notes> <label text="FLASH*"/> <bbox w="80.0" h="40.0" x="7683.25" y="965.25"/> </glyph> <glyph class="macromolecule" id="s6297_sa4021"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7668.25" y="925.25"/> <glyph class="state variable" id="_22fe56b5-bd57-4c88-8649-ec6e698b2008"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7658.25" y="931.9657"/> </glyph> </glyph> <glyph class="macromolecule" id="s5375_sa4073"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7883.25" y="895.25"/> </glyph> <glyph class="macromolecule" id="s5374_sa4074"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7883.25" y="940.25"/> <glyph class="state variable" id="_d2d37a58-f5f5-4333-ab96-70ffc03c1a1b"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7953.25" y="949.89465"/> </glyph> <glyph class="unit of information" id="_174777ea-a269-4cde-8442-46cc76d40fc0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7900.75" y="935.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5375_sa4075"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7893.25" y="905.25"/> </glyph> <glyph class="macromolecule" id="s5374_sa4076"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7893.25" y="950.25"/> <glyph class="state variable" id="_f8107459-8d18-49dd-b801-c248d50d8934"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7963.25" y="959.89465"/> </glyph> <glyph class="unit of information" id="_899e423e-cd5d-4941-83a3-01b0f47d4391"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7910.75" y="945.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5375_sa4077"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7903.25" y="915.25"/> </glyph> <glyph class="macromolecule" id="s5374_sa4078"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7903.25" y="960.25"/> <glyph class="state variable" id="_7e814e4c-5ade-4870-b52a-5baa7662c362"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7973.25" y="969.89465"/> </glyph> <glyph class="unit of information" id="_1f0cba80-d226-4350-ba8c-05c7cc4aec49"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7920.75" y="955.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s6297_sa4093"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7668.25" y="885.25"/> <glyph class="state variable" id="_5697e802-1187-41b9-8ced-a8d0746211e4"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7658.25" y="891.9657"/> </glyph> </glyph> <glyph class="macromolecule" id="s5386_sa4094"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="7673.25" y="1015.25"/> <glyph class="state variable" id="_a7b34647-f490-4615-89bc-dcf77a38ab7d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7668.25" y="1021.42114"/> </glyph> <glyph class="state variable" id="_20ee6601-59fc-4bf0-97a4-94432fb4e09e"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="7738.25" y="1021.5"/> </glyph> <glyph class="state variable" id="_09789eba-86c8-4f4b-acc7-27509335e00d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7711.0864" y="1010.25"/> </glyph> <glyph class="state variable" id="_c4d27d87-66dc-48ab-8387-754df5ad5ff2"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="7714.5806" y="1050.25"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s5400_sa4096" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11003656 References_end </body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="8247.5" y="575.0"/> </glyph> <glyph class="complex" id="s5401_csa415" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase8*:FLASH*:TRAF2 Identifiers_end References_begin: 15592525 caspase-8 formed triple complex with TRAF2 and FLASH endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH. 11340079 FLASH coordinates NF-kappa B activity via TRAF2 References_end </body> </html> </notes> <label text="Caspase8*:FLASH:TRAF2"/> <bbox w="100.0" h="160.0" x="11655.5" y="2660.5"/> <glyph class="macromolecule" id="s5403_sa4099"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28462525 References_end </body> </html> </notes> <label text="Caspase8*"/> <bbox w="80.0" h="40.0" x="11665.5" y="2670.5"/> <glyph class="state variable" id="_b0ce7df5-2e75-47dc-9b91-577722c00e72"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11655.5" y="2677.2158"/> </glyph> </glyph> <glyph class="macromolecule" id="s5402_sa4100"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <bbox w="80.0" h="40.0" x="11665.5" y="2710.5"/> </glyph> <glyph class="macromolecule" id="s5404_sa4101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 associated protein 2 HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival PMID:12702723 PMID:15592525 PMID:1134007 References_end </body> </html> </notes> <label text="FLASH*"/> <bbox w="80.0" h="40.0" x="11665.5" y="2750.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s5414_sa4105" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nerve growth factor receptor HUGO:NGFR HGNC:7809 ENTREZ:4804 UNIPROT:P08138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 PMID:15721744 References_end </body> </html> </notes> <label text="NGFR"/> <bbox w="80.0" h="50.0" x="3670.0" y="195.0"/> <glyph class="unit of information" id="_ef7d8976-e31a-400e-a797-28301725419c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3687.5" y="190.0"/> </glyph> </glyph> <glyph class="complex" id="s5419_csa416" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase3*:DCC:NTN1 Identifiers_end References_begin: DCC:Caspase3*:NTN1 19543238 netrin-1 triggers the multimerization of both DCC and UNC5H2 receptors, and that multimerization of the intracellular domain of DCC and UNC5H2 is the critical step to inhibit the proapoptotic effects of both of these receptors References_end </body> </html> </notes> <label text="multimerize DCC:NTN1"/> <bbox w="110.0" h="200.0" x="1303.0514" y="139.4311"/> <glyph class="macromolecule" id="s5420_sa4106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: deleted in colorectal carcinoma HUGO:DCC HGNC:2701 ENTREZ:1630 UNIPROT:P43146 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:11248093 References_end </body> </html> </notes> <label text="DCC"/> <bbox w="80.0" h="50.0" x="1313.0514" y="194.4311"/> <glyph class="unit of information" id="_4ae07a2c-095c-42f1-949f-cdbdd08748a4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1330.5514" y="189.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5420_sa4107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: deleted in colorectal carcinoma HUGO:DCC HGNC:2701 ENTREZ:1630 UNIPROT:P43146 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:11248093 References_end </body> </html> </notes> <label text="DCC"/> <bbox w="80.0" h="50.0" x="1323.0514" y="204.4311"/> <glyph class="unit of information" id="_9d2f5e3d-c3fb-4877-a61f-3cde8bded60a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1340.5514" y="199.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5421_sa4108"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <bbox w="80.0" h="40.0" x="1313.0514" y="149.4311"/> </glyph> <glyph class="macromolecule" id="s5421_sa4109"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <bbox w="80.0" h="40.0" x="1323.0514" y="159.4311"/> </glyph> <glyph class="macromolecule" id="s5430_sa4118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <bbox w="80.0" h="40.0" x="1313.0514" y="259.4311"/> </glyph> <glyph class="macromolecule" id="s5430_sa4119"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 3, apoptosis-related cysteine peptidase HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="Caspase3*"/> <bbox w="80.0" h="40.0" x="1323.0514" y="269.4311"/> </glyph> </glyph> <glyph class="complex" id="s5427_csa418" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CIP2A*:DAPK1:NTN1:UNC5B Identifiers_end References_begin: 19543238 21172653 UNC5H2/B recruits a protein complex that includes PR65β and DAPk and retains PP2A activity. PP2A activity is required for UNC5H2/B-induced apoptosis, since it activates DAPk by triggering its dephosphorylation. Moreover, netrin-1 binding to UNC5H2/B prevents this effect through interaction of the PP2A inhibitor CIP2A to UNC5H2/B 12598906 p53RDL1 interacted with its ligand, Netrin-1, p53-dependent apoptosis was blocked References_end </body> </html> </notes> <label text="multimerize UNCH2:NTN1"/> <bbox w="111.94857" h="230.5689" x="1888.0514" y="119.43111"/> <glyph class="macromolecule" id="s5428_sa4112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog B (C. elegans) HUGO:UNC5B HGNC:12568 ENTREZ:219699 UNIPROT:Q8IZJ1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:19543238 PMID:12598906 p53RDL1 mediated p53-dependent apoptosis. Conversely, when p53RDL1 interacted with its ligand, Netrin-1, p53-dependent apoptosis was blocked PMID:18582460 References_end </body> </html> </notes> <label text="UNC5B"/> <bbox w="80.0" h="50.0" x="1898.0514" y="174.4311"/> <glyph class="unit of information" id="_cdae2b61-af3b-4ea2-8587-a9ddcf8f79c1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1915.5514" y="169.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5428_sa4113"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog B (C. elegans) HUGO:UNC5B HGNC:12568 ENTREZ:219699 UNIPROT:Q8IZJ1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:19543238 PMID:12598906 p53RDL1 mediated p53-dependent apoptosis. Conversely, when p53RDL1 interacted with its ligand, Netrin-1, p53-dependent apoptosis was blocked PMID:18582460 References_end </body> </html> </notes> <label text="UNC5B"/> <bbox w="80.0" h="50.0" x="1908.0514" y="184.4311"/> <glyph class="unit of information" id="_d54db306-2b26-42b4-9a6d-9d85e429d8a2"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1925.5514" y="179.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5429_sa4114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <bbox w="80.0" h="40.0" x="1898.0514" y="129.4311"/> </glyph> <glyph class="macromolecule" id="s5429_sa4115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <bbox w="80.0" h="40.0" x="1908.0514" y="139.4311"/> </glyph> <glyph class="macromolecule" id="s5592_sa4134"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: death-associated protein kinase 1 HUGO:DAPK1 HGNC:2674 ENTREZ:1612 UNIPROT:P53355 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17703233 DAP kinase regulates JNK signaling by binding and activating protein kinase D References_end </body> </html> </notes> <label text="DAPK1"/> <bbox w="80.0" h="40.0" x="1908.0514" y="239.4311"/> <glyph class="state variable" id="_c1a0835f-b74f-4561-ba4f-5da8b98e40fa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1923.9829" y="234.4311"/> </glyph> <glyph class="state variable" id="_ef015353-7f07-4811-9c1f-60e0315696a3"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="1949.6199" y="234.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5738_sa4143"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: KIAA1524 HUGO:KIAA1524 HGNC:29302 ENTREZ:57650 UNIPROT:Q8TCG1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21172653 CIP2A is an inhibitor of UNC5H2/B-induced DAPk activation References_end </body> </html> </notes> <label text="CIP2A*"/> <bbox w="80.0" h="40.0" x="1908.0514" y="279.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5445_sa4128" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: deleted in colorectal carcinoma HUGO:DCC HGNC:2701 ENTREZ:1630 UNIPROT:P43146 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22920895 in the absence of his ligand, DCC is cleaved and induce apoptosis References_end </body> </html> </notes> <label text="Cleaved DCC*"/> <bbox w="80.0" h="50.0" x="1438.0514" y="194.4311"/> <glyph class="unit of information" id="_c9c9779d-1272-4c27-84a7-f2718f1cdc38"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1455.5514" y="189.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5449_sa4131" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 HUGO:APPL2 HGNC:18242 ENTREZ:55198 UNIPROT:Q8NEU8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12011067 DIP13 alpha is a mediator of the DCC apoptotic pathway PMID:22920895 References_end </body> </html> </notes> <label text="APPL2"/> <bbox w="80.0" h="40.0" x="1448.0514" y="299.4311"/> </glyph> <glyph class="complex" id="s5482_csa18" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DLAT:DLD:FAD:PDHA*:thiamine diphosphate Identifiers_end </body> </html> </notes> <label text="pyruvate dehydrogenase"/> <bbox w="268.0" h="96.0" x="2124.348" y="5835.5835"/> <glyph class="macromolecule" id="s5483_sa245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E2 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="2286.848" y="5845.0835"/> <glyph class="state variable" id="_7c5b43aa-0fe6-428b-90f4-556a4941ed50"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="2296.848" y="5840.0835"/> </glyph> </glyph> <glyph class="macromolecule" id="s5483_sa246"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E2 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="2294.848" y="5855.0835"/> <glyph class="state variable" id="_78090aae-de69-48d8-b3af-c0b39d40c3b1"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="2304.848" y="5850.0835"/> </glyph> </glyph> <glyph class="macromolecule" id="s5483_sa247"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E2 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="2306.848" y="5865.0835"/> <glyph class="state variable" id="_c322cf2d-b3d3-499f-a4bc-151b01193bac"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="2316.848" y="5860.0835"/> </glyph> </glyph> <glyph class="macromolecule" id="s5596_sa248"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="2209.848" y="5845.0835"/> <glyph class="state variable" id="_399f4776-011d-44ab-966c-68aa58d4a1b3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2258.9165" y="5840.0835"/> </glyph> </glyph> <glyph class="macromolecule" id="s5596_sa249"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="2219.848" y="5855.0835"/> <glyph class="state variable" id="_340ca7bc-6604-4ff9-9aa0-4d218d4406e5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2268.9165" y="5850.0835"/> </glyph> </glyph> <glyph class="macromolecule" id="s5596_sa250"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="2229.848" y="5865.0835"/> <glyph class="state variable" id="_6a2b578b-d3a6-401b-aad5-4a415a95679f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2278.9165" y="5860.0835"/> </glyph> </glyph> <glyph class="macromolecule" id="s5485_sa251"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E3 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="2129.598" y="5844.3335"/> </glyph> <glyph class="simple chemical" id="s5486_sa252"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="2135.598" y="5868.8335"/> </glyph> <glyph class="macromolecule" id="s5485_sa253"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E3 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="2139.598" y="5854.3335"/> </glyph> <glyph class="simple chemical" id="s5486_sa254"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="2145.598" y="5878.8335"/> </glyph> <glyph class="macromolecule" id="s5485_sa255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E3 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="2149.598" y="5864.3335"/> </glyph> <glyph class="simple chemical" id="s5486_sa256"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="2155.598" y="5888.8335"/> </glyph> <glyph class="simple chemical" id="s5487_sa3416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:9532 KEGGCOMPOUND: C00068 CAS:154-87-0 </body> </html> </notes> <label text="thiamine diphosphate"/> <bbox w="70.0" h="25.0" x="2231.444" y="5887.7773"/> </glyph> </glyph> <glyph class="complex" id="s5488_csa32" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a Identifiers_end References_begin: stoechiometry:FALSE References_end </body> </html> </notes> <label text="cytochrome c oxidase"/> <bbox w="420.0" h="150.0" x="1956.75" y="4620.0"/> <glyph class="macromolecule" id="s5489_sa415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase I HUGO:MT-CO1 HGNC:7419 ENTREZ:4512 UNIPROT:P00395 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO1"/> <bbox w="80.0" h="40.0" x="1962.75" y="4622.0"/> </glyph> <glyph class="macromolecule" id="s5490_sa416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase II HUGO:MT-CO2 HGNC:7421 ENTREZ:4513 UNIPROT:P00403 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO2"/> <bbox w="80.0" h="40.0" x="1962.75" y="4666.0"/> </glyph> <glyph class="macromolecule" id="s5491_sa417"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase III HUGO:MT-CO3 HGNC:7422 ENTREZ:4514 UNIPROT:P00414 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO3"/> <bbox w="80.0" h="40.0" x="1962.75" y="4706.0"/> </glyph> <glyph class="macromolecule" id="s1933_sa418"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit IV isoform 1 HUGO:COX4I1 HGNC:2265 ENTREZ:1327 UNIPROT:P13073 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX4I1"/> <bbox w="80.0" h="40.0" x="2044.75" y="4620.0"/> </glyph> <glyph class="macromolecule" id="s5492_sa419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit Va HUGO:COX5A HGNC:2267 ENTREZ:9377 UNIPROT:P20674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5A"/> <bbox w="80.0" h="40.0" x="2044.75" y="4662.0"/> </glyph> <glyph class="macromolecule" id="s5493_sa420"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit Vb HUGO:COX5B HGNC:2269 ENTREZ:1329 UNIPROT:P10606 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5B"/> <bbox w="80.0" h="40.0" x="2044.75" y="4704.0"/> </glyph> <glyph class="macromolecule" id="s5494_sa421"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIc HUGO:COX6C HGNC:2285 ENTREZ:1345 UNIPROT:P09669 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6C"/> <bbox w="80.0" h="40.0" x="2126.75" y="4704.0"/> </glyph> <glyph class="macromolecule" id="s5498_sa422"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIc HUGO:COX7C HGNC:2292 ENTREZ:1350 UNIPROT:P15954 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7C"/> <bbox w="80.0" h="40.0" x="2208.75" y="4704.0"/> </glyph> <glyph class="macromolecule" id="s5502_sa423"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIa polypeptide 1 HUGO:COX6A1 HGNC:2277 ENTREZ:1337 UNIPROT:P12074 cytochrome c oxidase subunit VIa polypeptide 2 HUGO:COX6A2 HGNC:2279 ENTREZ:1339 UNIPROT:Q02221 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6A*"/> <bbox w="80.0" h="40.0" x="2126.75" y="4620.0"/> </glyph> <glyph class="macromolecule" id="s5495_sa424"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) HUGO:COX6B1 HGNC:2280 ENTREZ:1340 UNIPROT:P14854 cytochrome c oxidase subunit VIb polypeptide 2 (testis) HUGO:COX6B2 HGNC:24380 ENTREZ:125965 UNIPROT:Q6YFQ2 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6B*"/> <bbox w="80.0" h="40.0" x="2126.75" y="4662.0"/> </glyph> <glyph class="macromolecule" id="s5496_sa425"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) HUGO:COX7A1 HGNC:2287 ENTREZ:1346 UNIPROT:P24310 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) HUGO:COX7A2 HGNC:2288 ENTREZ:1347 UNIPROT:P14406 cytochrome c oxidase subunit VIIa polypeptide 2 like HUGO:COX7A2L HGNC:2289 ENTREZ:9167 UNIPROT:O14548 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7A*"/> <bbox w="80.0" h="40.0" x="2208.75" y="4620.0"/> </glyph> <glyph class="macromolecule" id="s5497_sa426"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIb HUGO:COX7B HGNC:2291 ENTREZ:1349 UNIPROT:P24311 cytochrome c oxidase subunit VIIb2 HUGO:COX7B2 HGNC:24381 ENTREZ:170712 UNIPROT:Q8TF08 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7B*"/> <bbox w="80.0" h="40.0" x="2208.75" y="4662.0"/> </glyph> <glyph class="macromolecule" id="s5499_sa427"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIIA (ubiquitous) HUGO:COX8A HGNC:2294 ENTREZ:1351 UNIPROT:P10176 cytochrome c oxidase subunit VIIIC HUGO:COX8C HGNC:24382 ENTREZ:341947 UNIPROT:Q7Z4L0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX8*"/> <bbox w="80.0" h="40.0" x="2290.75" y="4620.0"/> </glyph> <glyph class="simple chemical" id="s5501_sa428"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29036 CAS:15158-11-9 </body> </html> </notes> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="2339.75" y="4673.0"/> </glyph> <glyph class="simple chemical" id="s5501_sa429"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29036 CAS:15158-11-9 </body> </html> </notes> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="2298.25" y="4673.5"/> </glyph> <glyph class="simple chemical" id="s5500_sa430"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:24479 KEGGCOMPOUND:C15670 CAS:18535-39-2 </body> </html> </notes> <label text="heme a"/> <bbox w="70.0" h="25.0" x="2295.75" y="4701.5"/> </glyph> <glyph class="simple chemical" id="s5500_sa431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:24479 KEGGCOMPOUND:C15670 CAS:18535-39-2 </body> </html> </notes> <label text="heme a"/> <bbox w="70.0" h="25.0" x="2295.75" y="4735.0"/> </glyph> </glyph> <glyph class="complex" id="s5506_csa91" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1:AKT1S1"/> <bbox w="180.0" h="112.0" x="9145.499" y="2519.326"/> <glyph class="macromolecule" id="s2081_sa1108"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PRAS References_end </body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="9235.499" y="2569.326"/> <glyph class="state variable" id="_8f9bd399-c437-4264-a63f-28c8609f5c87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9287.067" y="2564.326"/> </glyph> </glyph> <glyph class="macromolecule" id="s5509_sa1109"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9153.166" y="2526.6592"/> </glyph> <glyph class="macromolecule" id="s5508_sa1110"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="9153.166" y="2568.6592"/> </glyph> <glyph class="macromolecule" id="s5507_sa1111"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="9237.166" y="2526.6592"/> <glyph class="state variable" id="_7ececbd0-0be4-47f9-862f-8c2d119eead3"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9279.115" y="2521.6592"/> </glyph> <glyph class="state variable" id="_16924709-b463-4e29-946b-c3ef0091287f"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="9245.761" y="2521.6592"/> </glyph> <glyph class="state variable" id="_2dc1dffc-2f1d-4d22-b00c-d7bb277276d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9255.598" y="2561.6592"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5510_csa84" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end References_begin: PMID:23030059 References_end </body> </html> </notes> <label text="TSC1/2"/> <bbox w="100.0" h="135.0" x="8558.5" y="2750.8333"/> <glyph class="macromolecule" id="s2048_sa1086"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8569.167" y="2814.5"/> <glyph class="state variable" id="_08283933-df56-462c-beca-7e417c04025e"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="8608.616" y="2809.5"/> </glyph> <glyph class="state variable" id="_d496470b-4294-43c4-acc1-f4bf27697a1e"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="8577.762" y="2809.5"/> </glyph> <glyph class="state variable" id="_2be851e0-8087-4973-a621-8d6232c7e249"> <state value="" variable="S664"/> <bbox w="30.0" h="10.0" x="8554.167" y="2809.9395"/> </glyph> <glyph class="state variable" id="_f5ebc498-d61d-49d5-8cac-77bde5695d0d"> <state value="P" variable="S1345"/> <bbox w="40.0" h="10.0" x="8605.498" y="2849.5"/> </glyph> <glyph class="state variable" id="_e9da5f6a-2f64-485a-a87c-e4235f2d987c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8564.167" y="2829.5"/> </glyph> <glyph class="state variable" id="_7e67ab1f-073f-47f1-a3f6-723c9852c533"> <state value="" variable="S1798"/> <bbox w="35.0" h="10.0" x="8631.667" y="2810.0808"/> </glyph> <glyph class="state 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Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="8566.5" y="2763.5"/> <glyph class="state variable" id="_24b8885a-67cd-4079-9fd5-b25ee0cf4818"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="8608.449" y="2758.5"/> </glyph> <glyph class="state variable" id="_9354c299-8fc0-415b-869a-b54205a68b12"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="8575.095" y="2758.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5530_csa98" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Fe3+:PHD* Identifiers_end </body> </html> </notes> <label text="PHD"/> <bbox w="100.0" h="120.0" x="7521.5" y="5775.75"/> <glyph class="simple chemical" id="s2005_sa1175"> <label text="Fe3+"/> <bbox w="25.0" h="25.0" x="7555.0" y="5796.75"/> </glyph> <glyph class="macromolecule" id="s5531_sa1176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: egl nine homolog 1 (C. elegans) HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9 egl nine homolog 2 (C. elegans) HUGO:EGLN2 HGNC:14660 ENTREZ:112398 UNIPROT:Q96KS0 egl nine homolog 3 (C. elegans) HUGO:EGLN3 HGNC:14661 ENTREZ:112399 UNIPROT:Q9H6Z9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PHD*"/> <bbox w="80.0" h="40.0" x="7533.5" y="5829.75"/> </glyph> </glyph> <glyph class="complex" id="s5532_csa99" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HIF1A:HIF1B* Identifiers_end </body> </html> </notes> <label text="HIF1aHIF1b"/> <bbox w="97.5" h="130.0" x="5863.75" y="7590.0"/> <glyph class="macromolecule" id="s5533_sa1188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="5871.25" y="7650.0"/> <glyph class="state variable" id="_80d35b30-904c-4876-962a-452093cf37d0"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="5879.845" y="7645.0"/> </glyph> <glyph class="state variable" id="_fbf065f3-0c08-4557-a442-03cfd5fc52db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5922.8184" y="7645.0"/> </glyph> <glyph class="state variable" id="_0ba1dc3b-65d6-46a5-9ac6-a63df456d31a"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="5878.751" y="7685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5534_sa1189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aryl hydrocarbon receptor nuclear translocator HUGO:ARNT HGNC:700 ENTREZ:405 UNIPROT:P27540 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:HIF1beta References_end </body> </html> </notes> <label text="HIF1B*"/> <bbox w="80.0" h="40.0" x="5871.25" y="7600.0"/> </glyph> </glyph> <glyph class="complex" id="s5542_csa130" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BMF:DYNLL2 Identifiers_end </body> </html> </notes> <label text="myosin V motor complex:BMF"/> <bbox w="100.0" h="120.0" x="3763.1667" y="3008.25"/> <glyph class="macromolecule" id="s280_sa1370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="3771.1667" y="3024.25"/> <glyph class="state variable" id="_7a441dfa-08da-447d-817b-0d482b860b38"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3822.7354" y="3019.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5543_sa1371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dynein, light chain, LC8-type 2 HUGO:DYNLL2 HGNC:24596 ENTREZ:140735 UNIPROT:Q96FJ2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DYNLL2"/> <bbox w="80.0" h="40.0" x="3771.1667" y="3068.25"/> </glyph> </glyph> <glyph class="complex" id="s5550_csa347" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CHUK:IKBKG:IKK_beta_* Identifiers_end </body> </html> </notes> <label text="IKK complex"/> <bbox w="101.5" h="173.0" x="5642.25" y="828.75"/> <glyph class="macromolecule" id="s5551_sa3236"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <bbox w="80.0" h="40.0" x="5652.25" y="840.75"/> </glyph> <glyph class="macromolecule" id="s4207_sa3237"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end </body> </html> </notes> <label text="IKKβ*"/> <bbox w="80.0" h="40.0" x="5652.25" y="890.75"/> <glyph class="state variable" id="_b100a46b-4df3-4e8c-836b-9bdbfbad1093"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5668.1816" y="885.75"/> </glyph> <glyph class="state variable" id="_c99278ea-e6d6-4909-be3a-01b9d291ec5c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5703.8184" y="885.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5552_sa3238"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: conserved helix-loop-helix ubiquitous kinase HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 IKBK-alpha synonym:IKBKA synonym:IKK_alpha_ Maps_Modules_end References_end </body> </html> </notes> <label text="CHUK"/> <bbox w="80.0" h="40.0" x="5652.25" y="938.75"/> </glyph> </glyph> <glyph class="complex" id="s5553_csa355" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFKB1_p50*:NFKBIA:RELA Identifiers_end </body> </html> </notes> <label text="RELA:p50"/> <bbox w="97.0" h="167.0" x="5641.5" y="1426.5"/> <glyph class="macromolecule" id="s4124_sa3307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha HUGO:NFKBIA HGNC:7797 ENTREZ:4792 UNIPROT:P25963 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:I_kappa_B-_alpha_ References_end </body> </html> </notes> <label text="NFKBIA"/> <bbox w="80.0" h="40.0" x="5650.5" y="1438.5"/> <glyph class="state variable" id="_7b56b161-f3bd-49dd-a272-d5817ec565e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5668.9316" y="1433.5"/> </glyph> <glyph class="state 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y="1561.9805"/> </glyph> <glyph class="state variable" id="_cb612ce4-be1c-437f-91dc-00001b76bade"> <state value="" variable="T254"/> <bbox w="30.0" h="10.0" x="5690.995" y="1561.9805"/> </glyph> </glyph> <glyph class="macromolecule" id="s5555_sa3309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB1_p50*"/> <bbox w="80.0" h="40.0" x="5650.8223" y="1482.9805"/> <glyph class="unit of information" id="_37315258-879d-4daa-a781-f08474d3913b"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5665.8223" y="1477.9805"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5560_csa393" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CFLAR:Caspase8,10*:DR4/5*:FADD:MLKL:RIPK1:RIPK3:TRAIL* Identifiers_end References_begin: Caspase8,10*:FADD:TRAIL*:DR4/5*:RIPK1:RIPK3:CFLAR 20531300 19090789 References_end </body> </html> </notes> <label text="Caspase8,10*:FADD:TRAIL*:DR4/5*"/> <bbox w="300.625" h="221.17188" x="7649.6875" y="89.41406"/> <glyph class="macromolecule" id="s5183_sa3872"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CASP8 and FADD-like apoptosis regulator HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:15760909 PMID:19838173 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce References_end </body> </html> </notes> <label text="CFLAR"/> <bbox w="80.0" h="40.0" x="7660.9375" y="201.75781"/> <glyph class="state variable" id="_3a44a929-8502-4750-8903-4f6ebf570e35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7712.506" y="196.75781"/> </glyph> </glyph> <glyph class="macromolecule" id="s5561_sa3900"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7833.4375" y="94.57031"/> </glyph> <glyph class="macromolecule" id="s5562_sa3901"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7833.4375" y="139.57031"/> <glyph class="state variable" id="_b653d04e-9384-48c2-9a6e-7085f6df3b3d"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7863.4375" y="184.57031"/> </glyph> <glyph class="state variable" id="_6dbf6701-b521-415e-b3ad-c04229a53ca8"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7905.9375" y="159.57031"/> </glyph> <glyph class="unit of information" id="_d8e26c5b-e611-4ab1-939a-488285fffa1c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7850.9375" y="134.57031"/> </glyph> </glyph> <glyph class="macromolecule" id="s5563_sa3902"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7753.4375" y="139.57031"/> </glyph> <glyph class="macromolecule" id="s5561_sa3903"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7843.4375" y="104.57031"/> </glyph> <glyph class="macromolecule" id="s5562_sa3904"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7843.4375" y="149.57031"/> <glyph class="state variable" id="_01e3cedf-5dbf-4fc5-b6b5-be5bc5869ad9"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7873.4375" y="194.57031"/> </glyph> <glyph class="state variable" id="_fcfe10f0-a1ca-4d3f-a8e4-3d06320f5ae9"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7915.9375" y="169.57031"/> </glyph> <glyph class="unit of information" id="_bf3a5e0e-682c-415d-bbfb-4f84bb5382a3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7860.9375" y="144.57031"/> </glyph> </glyph> <glyph class="macromolecule" id="s5563_sa3905"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7763.4375" y="149.57031"/> </glyph> <glyph class="macromolecule" id="s5561_sa3906"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7853.4375" y="114.57031"/> </glyph> <glyph class="macromolecule" id="s5562_sa3907"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7853.4375" y="159.57031"/> <glyph class="state variable" id="_4bf23734-e8ed-4f2d-bfd9-f459af4d6978"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7883.4375" y="204.57031"/> </glyph> <glyph class="state variable" id="_b4569ed5-047a-4357-ad5c-f062cfcb989a"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7925.9375" y="179.57031"/> </glyph> <glyph class="unit of information" id="_4186f95d-25ad-4487-a545-d6df28017e9f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7870.9375" y="154.57031"/> </glyph> </glyph> <glyph class="macromolecule" id="s5563_sa3908"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7773.4375" y="159.57031"/> </glyph> <glyph class="macromolecule" id="s5622_sa3909"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7768.4375" y="224.57031"/> <glyph class="state variable" id="_3f362c2a-639f-4e33-b665-63043c69b06d"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7758.4375" y="231.28604"/> </glyph> </glyph> <glyph class="macromolecule" id="s5622_sa3912"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7758.4375" y="214.57031"/> <glyph class="state variable" id="_13116f6e-1998-4699-8c04-e4d2c0a4d84b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7748.4375" y="221.28604"/> </glyph> </glyph> <glyph class="macromolecule" id="s5622_sa3913"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7748.4375" y="204.57031"/> <glyph class="state variable" id="_1e986cf1-ee69-4b07-b03a-2ab1c7366a51"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7738.4375" y="211.28604"/> </glyph> </glyph> <glyph class="macromolecule" id="s5195_sa3935"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="7659.6875" y="149.41406"/> <glyph class="state variable" id="_28f936f3-9fbc-40e2-8d7b-56686a2fce35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7654.6875" y="155.58522"/> </glyph> <glyph class="state variable" 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MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="7660.3125" y="100.58594"/> <glyph class="state variable" id="_3dc642f4-37d5-4e67-af3b-cb4e381d8379"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="7645.805" y="95.58594"/> </glyph> <glyph class="state variable" id="_48a7585b-4ea4-48a0-bd16-faaae15f4730"> <state value="" variable="S199"/> <bbox w="30.0" h="10.0" x="7702.2617" y="95.58594"/> </glyph> </glyph> <glyph class="macromolecule" id="s5197_sa3937"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mixed lineage kinase domain-like HUGO:MLKL HGNC:26617 ENTREZ:197259 UNIPROT:Q8NB16 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 PMID:24366341 PMID:26024392 PMID:26853145 Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. PMID:28498367 References_end </body> </html> </notes> <label text="MLKL"/> <bbox w="80.0" h="40.0" x="7660.3125" y="250.58594"/> <glyph class="state variable" id="_2869e763-872a-4502-97d4-582abe38078c"> <state value="" variable="T357"/> <bbox w="30.0" h="10.0" x="7645.3125" y="257.0925"/> </glyph> <glyph class="state variable" id="_b6815369-4c80-48dd-a3c4-902e7d3ccc42"> <state value="" variable="S358"/> <bbox w="30.0" h="10.0" x="7668.9077" y="245.58594"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5573_csa414" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ASK1*:CFLAR:Caspase8,10*:DAXX:FADD:FAF1:FAS:FASLG:FLASH*:RIPK1:TRAF2 Identifiers_end References_begin: 10*:RIPK1:CFLAR:FLASH*:ASK1*:FAF1:FADD:DAXX:FASLG:FAS 23069999 References_end </body> </html> </notes> <label text="FAS:FASLG:FADD:DAXX:ASK1"/> <bbox w="419.375" h="197.8125" x="7583.875" y="1387.4375"/> <glyph class="macromolecule" id="s6079_sa4034"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7805.875" y="1435.9375"/> </glyph> <glyph class="macromolecule" id="s6078_sa4035"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CASP8 and FADD-like apoptosis regulator HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:15760909 PMID:19838173 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce References_end </body> </html> </notes> <label text="CFLAR"/> <bbox w="80.0" h="40.0" x="7725.875" y="1395.9375"/> <glyph class="state variable" id="_0ffde69e-4a8e-4d49-a3e3-83695e20cc27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7777.4434" y="1390.9375"/> </glyph> </glyph> <glyph class="macromolecule" id="s6077_sa4036"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 associated protein 2 HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival PMID:12702723 PMID:15592525 PMID:1134007 References_end </body> </html> </notes> <label text="FLASH*"/> <bbox w="80.0" h="40.0" x="7725.875" y="1435.9375"/> </glyph> <glyph class="macromolecule" id="s6080_sa4038"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12702723 FAF1 is a member of Fas-DISC acting upstream of caspase-8 PMID:19597341 FAF1 downregulation may contribute to multiple aspects of tumorigenesis References_end </body> </html> </notes> <label text="FAF1"/> <bbox w="80.0" h="40.0" x="7805.875" y="1395.9375"/> </glyph> <glyph class="macromolecule" id="s6081_sa4039"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:15592525 References_end </body> </html> </notes> <label text="TRAF2"/> <bbox w="80.0" h="40.0" x="7617.25" y="1402.25"/> </glyph> <glyph class="macromolecule" id="s6301_sa4042"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7599.25" y="1451.25"/> <glyph class="state variable" id="_6a556a6c-db61-4e8c-9ec8-eb6e27290758"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7589.25" y="1457.9657"/> </glyph> </glyph> <glyph class="macromolecule" id="s6076_sa4085"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7892.625" y="1393.0625"/> </glyph> <glyph class="macromolecule" id="s5580_sa4086"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7892.625" y="1438.0625"/> <glyph class="state variable" id="_9671332b-244b-4822-afc4-db2884a5e3a0"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7962.625" y="1447.7072"/> </glyph> <glyph class="unit of information" id="_413ddff3-4f37-4ba9-a47f-cabcd9827756"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7910.125" y="1433.0625"/> </glyph> </glyph> <glyph class="macromolecule" id="s6076_sa4087"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7902.625" y="1403.0625"/> </glyph> <glyph class="macromolecule" id="s5580_sa4088"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7902.625" y="1448.0625"/> <glyph class="state variable" id="_f262a510-caec-4245-ba25-9604eef447dc"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7972.625" y="1457.7072"/> </glyph> <glyph class="unit of information" id="_6199f88d-33dd-46e5-88d6-744f4297e160"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7920.125" y="1443.0625"/> </glyph> </glyph> <glyph class="macromolecule" id="s6076_sa4089"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7912.625" y="1413.0625"/> </glyph> <glyph class="macromolecule" id="s5580_sa4090"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7912.625" y="1458.0625"/> <glyph class="state variable" id="_affe68dd-54eb-4720-9cce-7b768dee4103"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7982.625" y="1467.7072"/> </glyph> <glyph class="unit of information" id="_df0f5339-9ec5-4f60-b4bb-6f7f16e54fb0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7930.125" y="1453.0625"/> </glyph> </glyph> <glyph class="macromolecule" id="s5383_sa4091"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:11003656 References_end </body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="7803.25" y="1485.25"/> </glyph> <glyph class="macromolecule" id="s5385_sa4092"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="7713.25" y="1505.25"/> <glyph class="state variable" id="_3e21ef6c-d45e-4336-b43a-1a22964667cd"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="7721.845" y="1500.25"/> </glyph> <glyph class="state variable" id="_fa44693c-0a5f-4311-bcbc-0961b5aed749"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7764.8184" y="1500.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5399_sa4095"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="7613.25" y="1515.25"/> <glyph class="state variable" id="_d7ec4ecc-9ca9-4ee9-b8a7-9b3a2446430e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7608.25" y="1521.4211"/> </glyph> <glyph class="state variable" id="_7d52fbf1-ea5f-45df-9e12-d85ae26a2c6d"> <state value="Ub" variable="K377"/> <bbox w="40.0" h="10.0" x="7673.25" y="1521.5"/> </glyph> <glyph class="state variable" id="_d6828abc-46c6-41b1-a3c5-f85a4eaf9da6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7651.0864" y="1510.25"/> </glyph> <glyph class="state variable" id="_92f806c2-83b3-4372-87f5-894b8e7f5064"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="7654.5806" y="1550.25"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5581_csa420" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APPL2:Cleaved DCC*:cleaved~Caspase9* Identifiers_end References_begin: DCC*:APPL2:cleaved Caspase9* 11248093 22920895 References_end </body> </html> </notes> <label text="DCC:NTN1"/> <bbox w="100.0" h="170.0" x="1738.0514" y="189.4311"/> <glyph class="macromolecule" id="s5444_sa4123"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="cleaved~Caspase9*"/> <bbox w="80.0" h="40.0" x="1748.0514" y="299.4311"/> <glyph class="unit of information" id="_58213337-384d-4ed9-9b0d-d183379bc302"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1763.0514" y="294.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5582_sa4127"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 HUGO:APPL2 HGNC:18242 ENTREZ:55198 UNIPROT:Q8NEU8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12011067 DIP13 alpha is a mediator of the DCC apoptotic pathway PMID:22920895 References_end </body> </html> </notes> <label text="APPL2"/> <bbox w="80.0" h="40.0" x="1748.0514" y="249.4311"/> </glyph> <glyph class="macromolecule" id="s5583_sa4130"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: deleted in colorectal carcinoma HUGO:DCC HGNC:2701 ENTREZ:1630 UNIPROT:P43146 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22920895 in the absence of his ligand, DCC is cleaved and induce apoptosis References_end </body> </html> </notes> <label text="Cleaved DCC*"/> <bbox w="80.0" h="50.0" x="1748.0514" y="194.4311"/> <glyph class="unit of information" id="_ceb2b167-498e-49e3-8ce5-04c3f44ac3c4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1765.5514" y="189.4311"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s5590_sa4150" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-5 homolog B (C. elegans) HUGO:UNC5B HGNC:12568 ENTREZ:219699 UNIPROT:Q8IZJ1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:11387206 PMID:18582460 PMID:21172648 in the absence of ligand, the intracellular domain of monomeric UNC5B undergoes cleavage References_end </body> </html> </notes> <label text="cleaved UNC5B*"/> <bbox w="80.0" h="50.0" x="2238.0515" y="174.4311"/> <glyph class="unit of information" id="_de8201b3-93ac-475a-af91-ec3aec33aafe"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2255.5515" y="169.4311"/> </glyph> </glyph> <glyph class="complex" id="s5625_csa16" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DLAT:DLD:FAD:PDHA*:thiamine diphosphate Identifiers_end </body> </html> </notes> <label text="pyruvate dehydrogenase"/> <bbox w="268.0" h="96.0" x="1663.4166" y="5837.3335"/> <glyph class="macromolecule" id="s5626_sa218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E2 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="1825.9166" y="5846.8335"/> <glyph class="state variable" id="_aa9a86dc-3539-46cf-8f08-a0cd93d9c145"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="1835.9166" y="5841.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="s5626_sa219"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E2 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="1833.9166" y="5856.8335"/> <glyph class="state variable" id="_6bc93fa9-cffb-4b28-91ab-f04f85580358"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="1843.9166" y="5851.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="s5626_sa220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E2 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide S-acetyltransferase HUGO:DLAT HGNC:2896 ENTREZ:1737 UNIPROT:P10515 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide S-acetyltransferase References_end </body> </html> </notes> <label text="DLAT"/> <bbox w="80.0" h="40.0" x="1845.9166" y="5866.8335"/> <glyph class="state variable" id="_e83668d4-fade-4eae-8ca5-24d45ea0ab6b"> <state value="lipoylated" variable=""/> <bbox w="60.0" h="10.0" x="1855.9166" y="5861.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="s5627_sa221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="1748.9166" y="5846.8335"/> <glyph class="state variable" id="_eea511af-d257-43b6-a93c-b09fc126f35d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1800.4851" y="5841.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="s5627_sa222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="1758.9166" y="5856.8335"/> <glyph class="state variable" id="_283465c5-7248-4a19-82b9-c65e4fb72c0e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1810.4851" y="5851.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="s5627_sa223"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: pyruvate dehydrogenase (lipoamide) alpha 1 HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559 pyruvate dehydrogenase (lipoamide) alpha 2 HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PDHA*"/> <bbox w="80.0" h="40.0" x="1768.9166" y="5866.8335"/> <glyph class="state variable" id="_79b2cc8f-2c8c-43c8-9972-52f7247a8bc8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1820.4851" y="5861.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="s5628_sa224"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E3 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="1668.6666" y="5846.0835"/> </glyph> <glyph class="simple chemical" id="s5629_sa225"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="1674.6666" y="5870.5835"/> </glyph> <glyph class="macromolecule" id="s5628_sa226"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E3 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="1678.6666" y="5856.0835"/> </glyph> <glyph class="simple chemical" id="s5629_sa227"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="1684.6666" y="5880.5835"/> </glyph> <glyph class="macromolecule" id="s5628_sa228"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> E3 in this complex ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dihydrolipoamide dehydrogenase HUGO:DLD HGNC:2898 ENTREZ:1738 UNIPROT:P09622 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end References_begin: synonym:dihydrolipoamide dehydrogenase References_end </body> </html> </notes> <label text="DLD"/> <bbox w="80.0" h="40.0" x="1688.6666" y="5866.0835"/> </glyph> <glyph class="simple chemical" id="s5629_sa229"> <label text="FAD"/> <bbox w="70.0" h="25.0" x="1694.6666" y="5890.5835"/> </glyph> <glyph class="simple chemical" id="s5630_sa3415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:9532 KEGGCOMPOUND: C00068 CAS:154-87-0 </body> </html> </notes> <label text="thiamine diphosphate"/> <bbox w="70.0" h="25.0" x="1773.4441" y="5891.7773"/> </glyph> </glyph> <glyph class="complex" id="s5631_csa34" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:COX4I2:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a Identifiers_end References_begin: stoechiometry:FALSE References_end </body> </html> </notes> <label text="cytochrome c oxidase"/> <bbox w="420.0" h="150.0" x="1466.75" y="4620.0"/> <glyph class="macromolecule" id="s5632_sa434"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase I HUGO:MT-CO1 HGNC:7419 ENTREZ:4512 UNIPROT:P00395 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO1"/> <bbox w="80.0" h="40.0" x="1472.75" y="4622.0"/> </glyph> <glyph class="macromolecule" id="s5633_sa435"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase II HUGO:MT-CO2 HGNC:7421 ENTREZ:4513 UNIPROT:P00403 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO2"/> <bbox w="80.0" h="40.0" x="1472.75" y="4666.0"/> </glyph> <glyph class="macromolecule" id="s5634_sa436"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitochondrially encoded cytochrome c oxidase III HUGO:MT-CO3 HGNC:7422 ENTREZ:4514 UNIPROT:P00414 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="MT-CO3"/> <bbox w="80.0" h="40.0" x="1472.75" y="4706.0"/> </glyph> <glyph class="macromolecule" id="s5635_sa437"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit Va HUGO:COX5A HGNC:2267 ENTREZ:9377 UNIPROT:P20674 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5A"/> <bbox w="80.0" h="40.0" x="1554.75" y="4662.0"/> </glyph> <glyph class="macromolecule" id="s5636_sa438"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit Vb HUGO:COX5B HGNC:2269 ENTREZ:1329 UNIPROT:P10606 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX5B"/> <bbox w="80.0" h="40.0" x="1554.75" y="4704.0"/> </glyph> <glyph class="macromolecule" id="s5637_sa439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIc HUGO:COX6C HGNC:2285 ENTREZ:1345 UNIPROT:P09669 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6C"/> <bbox w="80.0" h="40.0" x="1636.75" y="4704.0"/> </glyph> <glyph class="macromolecule" id="s5638_sa440"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) HUGO:COX6B1 HGNC:2280 ENTREZ:1340 UNIPROT:P14854 cytochrome c oxidase subunit VIb polypeptide 2 (testis) HUGO:COX6B2 HGNC:24380 ENTREZ:125965 UNIPROT:Q6YFQ2 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6B*"/> <bbox w="80.0" h="40.0" x="1636.75" y="4662.0"/> </glyph> <glyph class="macromolecule" id="s5639_sa441"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) HUGO:COX7A1 HGNC:2287 ENTREZ:1346 UNIPROT:P24310 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) HUGO:COX7A2 HGNC:2288 ENTREZ:1347 UNIPROT:P14406 cytochrome c oxidase subunit VIIa polypeptide 2 like HUGO:COX7A2L HGNC:2289 ENTREZ:9167 UNIPROT:O14548 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7A*"/> <bbox w="80.0" h="40.0" x="1718.75" y="4620.0"/> </glyph> <glyph class="macromolecule" id="s5640_sa442"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIb HUGO:COX7B HGNC:2291 ENTREZ:1349 UNIPROT:P24311 cytochrome c oxidase subunit VIIb2 HUGO:COX7B2 HGNC:24381 ENTREZ:170712 UNIPROT:Q8TF08 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7B*"/> <bbox w="80.0" h="40.0" x="1718.75" y="4662.0"/> </glyph> <glyph class="macromolecule" id="s5641_sa443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIc HUGO:COX7C HGNC:2292 ENTREZ:1350 UNIPROT:P15954 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX7C"/> <bbox w="80.0" h="40.0" x="1718.75" y="4704.0"/> </glyph> <glyph class="macromolecule" id="s5642_sa444"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIIIA (ubiquitous) HUGO:COX8A HGNC:2294 ENTREZ:1351 UNIPROT:P10176 cytochrome c oxidase subunit VIIIC HUGO:COX8C HGNC:24382 ENTREZ:341947 UNIPROT:Q7Z4L0 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX8*"/> <bbox w="80.0" h="40.0" x="1800.75" y="4620.0"/> </glyph> <glyph class="simple chemical" id="s5643_sa445"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:24479 KEGGCOMPOUND:C15670 CAS:18535-39-2 </body> </html> </notes> <label text="heme a"/> <bbox w="70.0" h="25.0" x="1805.75" y="4701.5"/> </glyph> <glyph class="simple chemical" id="s5643_sa446"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:24479 KEGGCOMPOUND:C15670 CAS:18535-39-2 </body> </html> </notes> <label text="heme a"/> <bbox w="70.0" h="25.0" x="1805.75" y="4735.0"/> </glyph> <glyph class="simple chemical" id="s5644_sa447"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29036 CAS:15158-11-9 </body> </html> </notes> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="1849.75" y="4673.0"/> </glyph> <glyph class="simple chemical" id="s5644_sa448"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29036 CAS:15158-11-9 </body> </html> </notes> <label text="Cu2+"/> <bbox w="25.0" h="25.0" x="1808.25" y="4673.5"/> </glyph> <glyph class="macromolecule" id="s5645_sa449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit VIa polypeptide 1 HUGO:COX6A1 HGNC:2277 ENTREZ:1337 UNIPROT:P12074 cytochrome c oxidase subunit VIa polypeptide 2 HUGO:COX6A2 HGNC:2279 ENTREZ:1339 UNIPROT:Q02221 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX6A*"/> <bbox w="80.0" h="40.0" x="1636.75" y="4620.0"/> </glyph> <glyph class="macromolecule" id="s1710_sa450"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c oxidase subunit IV isoform 2 (lung) HUGO:COX4I2 HGNC:16232 ENTREZ:84701 UNIPROT:Q96KJ9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="COX4I2"/> <bbox w="80.0" h="40.0" x="1554.75" y="4623.0"/> </glyph> </glyph> <glyph class="complex" id="s5646_csa28" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytochrome_C*:cardiolipin Identifiers_end </body> </html> </notes> <label text="ferroCYCS"/> <clone/> <bbox w="100.0" h="120.0" x="2082.75" y="5060.33"/> <glyph class="simple chemical" id="s5647_sa391"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:28494 KEGGCOMPOUND:C05980 </body> </html> </notes> <label text="cardiolipin"/> <clone/> <bbox w="70.0" h="25.0" x="2097.75" y="5121.33"/> </glyph> <glyph class="macromolecule" id="s5648_sa2247"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <clone/> <bbox w="80.0" h="40.0" x="2093.75" y="5076.0"/> <glyph class="state variable" id="_afaddc0c-17bc-4d57-8a7e-0623521861cb"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="2106.25" y="5071.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5646_csa299" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytochrome_C*:cardiolipin Identifiers_end </body> </html> </notes> <label text="ferroCYCS"/> <clone/> <bbox w="100.0" h="120.0" x="3386.75" y="4580.0"/> <glyph class="simple chemical" id="s5647_sa2560"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:28494 KEGGCOMPOUND:C05980 </body> </html> </notes> <label text="cardiolipin"/> <clone/> <bbox w="70.0" h="25.0" x="3401.75" y="4641.0"/> </glyph> <glyph class="macromolecule" id="s5648_sa2561"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <clone/> <bbox w="80.0" h="40.0" x="3397.0278" y="4594.2583"/> <glyph class="state variable" id="_a1b6a8ac-e310-4df6-9995-f62f63687c24"> <state value="ferroheme" variable=""/> <bbox w="55.0" h="10.0" x="3409.5278" y="4589.2583"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5649_csa94" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1:AKT1S1"/> <bbox w="180.0" h="112.0" x="9198.166" y="2326.6592"/> <glyph class="macromolecule" id="s2091_sa1117"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:PRAS References_end </body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="9288.166" y="2376.6592"/> <glyph class="state variable" id="_9778402e-81a6-4082-836f-7e1e65051116"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9337.234" y="2371.6592"/> </glyph> </glyph> <glyph class="macromolecule" id="s5650_sa1118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="9289.833" y="2333.9924"/> <glyph class="state variable" id="_a2b66ec0-c3c0-4b45-88d3-4700160ca9f8"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9331.782" y="2328.9924"/> </glyph> <glyph class="state variable" 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text="MTOR"/> <bbox w="80.0" h="40.0" x="9205.833" y="2375.9924"/> </glyph> <glyph class="macromolecule" id="s5652_sa1120"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="9205.833" y="2333.9924"/> </glyph> </glyph> <glyph class="complex" id="s5653_csa79" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end </body> </html> </notes> <label text="TSC1/2"/> <bbox w="100.0" h="140.0" x="8215.0" y="2895.0"/> <glyph class="macromolecule" id="s2047_sa1076"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8225.0" y="2965.0"/> <glyph class="state variable" id="_32f937c6-e8f3-4519-a115-c09ddbf8cbe5"> <state value="P" variable="T1462"/> <bbox w="40.0" h="10.0" x="8261.949" y="2960.0"/> </glyph> <glyph class="state variable" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="7885.0" y="3005.0"/> <glyph class="state variable" id="_971c7849-744a-439f-ab07-3fe5165ef8f5"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="7924.449" y="3000.0"/> </glyph> <glyph class="state variable" id="_9f8e58da-b640-4681-9dd4-3257b768ae51"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="7893.595" y="3000.0"/> </glyph> <glyph class="state variable" id="_52b88cd6-bc46-4fcb-a4eb-a54691e6f0d6"> <state value="" variable="S664"/> <bbox w="30.0" h="10.0" x="7870.0" y="3000.4395"/> </glyph> <glyph class="state variable" id="_3c800f92-797e-4c9b-ab26-7ec4e919f7fc"> <state value="" variable="S1345"/> <bbox w="35.0" 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compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end </body> </html> </notes> <label text="TSC1/2"/> <bbox w="100.0" h="135.0" x="8705.0" y="2747.5"/> <glyph class="macromolecule" id="s2225_sa1088"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8715.667" y="2811.1667"/> <glyph class="state variable" id="_48a6b308-030a-449a-8dab-7036e707104a"> <state value="" 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Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="8714.0" y="2762.1667"/> <glyph class="state variable" id="_694d9404-dffc-48e1-9a3a-eee26b1606c5"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="8755.949" y="2757.1667"/> </glyph> <glyph class="state variable" id="_3ffdd782-38bd-4ba1-9463-cead903f2a71"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="8722.595" y="2757.1667"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5659_csa80" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end </body> </html> </notes> <label text="TSC1/2"/> <bbox w="102.0" h="141.0" x="8402.5" y="2746.8333"/> <glyph class="macromolecule" id="s5513_sa1078"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="8415.0" y="2815.0"/> <glyph class="state variable" id="_d483ee81-63f2-4651-8e57-f0a03edac3a5"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="8454.449" y="2810.0"/> </glyph> <glyph class="state variable" id="_246d6e7e-8b90-475a-83fa-5adbee5db493"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="8423.595" y="2810.0"/> </glyph> <glyph class="state variable" id="_ef7fd8a5-9541-4b2a-b59f-e20bdf826b93"> <state value="" variable="S664"/> <bbox w="30.0" h="10.0" x="8400.0" y="2810.4395"/> </glyph> <glyph class="state variable" id="_5278965e-d95e-4402-abc7-637ff6078a20"> <state value="" variable="S1345"/> <bbox w="35.0" h="10.0" x="8453.831" y="2850.0"/> </glyph> <glyph class="state variable" id="_5361d5af-d292-4f53-b2a1-2159b3a0a4d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8410.0" y="2830.0"/> </glyph> <glyph class="state variable" id="_b2efa75e-534a-4d34-8ff2-eceaf19d6599"> <state value="" variable="S1798"/> <bbox w="35.0" h="10.0" x="8477.5" y="2810.5808"/> </glyph> <glyph class="state variable" id="_a0dce97f-1284-46a5-a63e-44805072f8c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8490.0" y="2850.0"/> </glyph> <glyph class="state variable" id="_f33f8340-bec6-45fe-aaae-2abc158e5ad3"> <state value="" variable="S1341"/> <bbox w="35.0" h="10.0" x="8435.176" y="2850.0"/> </glyph> <glyph class="state variable" id="_94f768ff-ec34-4569-b143-d189fc779a56"> <state value="" variable="S1337"/> <bbox w="35.0" h="10.0" x="8418.219" y="2850.0"/> </glyph> <glyph class="state variable" id="_e7d3207d-a385-44ab-98e2-87e17b0b1112"> <state value="?" variable="M1"/> <bbox w="25.0" h="10.0" x="8402.5" y="2849.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="s5660_sa1079"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="8415.0" y="2765.0"/> <glyph class="state variable" id="_f5ad5c02-e8e3-430f-8ec2-91a4c1058bb5"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="8456.949" y="2760.0"/> </glyph> <glyph class="state variable" id="_a851f7d5-f79d-48d4-94d3-46e4f0159fa3"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="8423.595" y="2760.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5661_csa82" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end </body> </html> </notes> <label text="TSC1/2"/> <bbox w="114.49006" h="117.45013" x="8400.51" y="3067.5498"/> <glyph class="macromolecule" id="s2141_sa1082"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label 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variable="S1798"/> <bbox w="40.0" h="10.0" x="8475.0" y="3120.5808"/> </glyph> <glyph class="state variable" id="_e19e2554-3fb9-4e7b-8455-b03eb69a01f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8490.0" y="3160.0"/> </glyph> <glyph class="state variable" id="_736db53a-e91a-4ac7-a6de-f6ed16cd7f3a"> <state value="" variable="S1341"/> <bbox w="35.0" h="10.0" x="8435.176" y="3160.0"/> </glyph> <glyph class="state variable" id="_9a8fb0a1-9de4-4a52-9faf-4643415174e5"> <state value="" variable="S1337"/> <bbox w="35.0" h="10.0" x="8418.219" y="3160.0"/> </glyph> <glyph class="state variable" id="_a2366e03-e219-4c9f-9901-3f14057838b8"> <state value="?" variable="M1"/> <bbox w="25.0" h="10.0" x="8402.5" y="3159.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="s5662_sa1083"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="8415.0" y="3075.0"/> <glyph class="state variable" id="_6502fe4e-bb0e-44a3-b629-5ebc4baaeeda"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="8456.949" y="3070.0"/> </glyph> <glyph class="state variable" id="_fffa5827-1da6-4b30-bb75-fdcfc0f0b39c"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="8423.595" y="3070.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5667_csa90" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1"/> <bbox w="93.0" h="151.0" x="8953.5" y="2719.5"/> <glyph class="macromolecule" id="s5668_sa1105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="8960.5" y="2767.5"/> </glyph> <glyph class="macromolecule" id="s3075_sa1106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="8960.5" y="2809.5"/> <glyph class="state variable" id="_19ba80e2-9557-4fac-8d0f-337c4a977c9f"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9002.449" y="2804.5"/> </glyph> <glyph class="state variable" id="_ff164dc3-de3f-4a4f-895f-144aaed6943c"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="8969.095" y="2804.5"/> </glyph> <glyph class="state variable" id="_552a537c-6c2b-4a4e-8bfb-5d57ed8633ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8976.432" y="2844.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s5669_sa1107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="8960.5" y="2725.5"/> </glyph> </glyph> <glyph class="complex" id="s5670_csa87" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1"/> <bbox w="91.5" h="165.5" x="8955.0" y="2485.0"/> <glyph class="macromolecule" id="s5671_sa1098"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="8960.5" y="2547.5"/> </glyph> <glyph class="macromolecule" id="s2064_sa1099"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="8960.5" y="2589.5"/> <glyph class="state variable" id="_2e0a17f0-3551-4f14-9e9e-c495086510b3"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9002.449" y="2584.5"/> </glyph> <glyph class="state variable" id="_b4c2f48d-2b78-46ea-b454-de810cf7c97c"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="8969.095" y="2584.5"/> </glyph> <glyph class="state variable" id="_27af1b28-b70d-4cc5-a306-5142b92f6a82"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8978.932" y="2624.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s5672_sa1100"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="8960.5" y="2505.5"/> </glyph> </glyph> <glyph class="complex" id="s5673_csa97" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Fe2+:PHD* Identifiers_end </body> </html> </notes> <label text="PHD"/> <bbox w="100.0" h="120.0" x="7521.5" y="5955.75"/> <glyph class="macromolecule" id="s5674_sa1157"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: egl nine homolog 1 (C. elegans) HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9 egl nine homolog 2 (C. elegans) HUGO:EGLN2 HGNC:14660 ENTREZ:112398 UNIPROT:Q96KS0 egl nine homolog 3 (C. elegans) HUGO:EGLN3 HGNC:14661 ENTREZ:112399 UNIPROT:Q9H6Z9 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PHD*"/> <bbox w="80.0" h="40.0" x="7527.0" y="5993.5"/> </glyph> <glyph class="simple chemical" id="s2435_sa1173"> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="7545.0" y="5966.75"/> </glyph> </glyph> <glyph class="complex" id="s5675_csa104" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CITED2:HIF1A:HIF1B* Identifiers_end </body> </html> </notes> <label text="HIF1aHIF1b"/> <bbox w="100.0" h="184.0" x="6092.5" y="7853.0"/> <glyph class="macromolecule" id="s5676_sa1200"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="6102.5" y="7917.0"/> <glyph class="state variable" id="_a2c2cbcf-3ec0-4665-b996-56219137fdad"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="6111.095" y="7912.0"/> </glyph> <glyph class="state variable" id="_c2e0c626-3b12-438d-94a0-800973b91b89"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6154.0684" y="7912.0"/> </glyph> <glyph class="state variable" id="_d6575602-0285-46fa-b56a-6b9da1d6435f"> <state value="" variable="N803"/> <bbox w="30.0" h="10.0" x="6110.001" y="7952.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5677_sa1201"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aryl hydrocarbon receptor nuclear translocator HUGO:ARNT HGNC:700 ENTREZ:405 UNIPROT:P27540 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:HIF1beta References_end </body> </html> </notes> <label text="HIF1B*"/> <bbox w="80.0" h="40.0" x="6102.5" y="7867.0"/> </glyph> <glyph class="macromolecule" id="s2133_sa1202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 HUGO:CITED2 HGNC:1987 ENTREZ:10370 UNIPROT:Q99967 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CITED2"/> <bbox w="80.0" h="40.0" x="6102.5" y="7967.0"/> </glyph> </glyph> <glyph class="complex" id="s5678_csa101" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HIF1A:HIF1B* Identifiers_end </body> </html> </notes> <label text="HIF1aHIF1b"/> <bbox w="100.0" h="130.0" x="5862.5" y="7850.0"/> <glyph class="macromolecule" id="s2448_sa1192"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HIF1A"/> <bbox w="80.0" h="40.0" x="5872.5" y="7910.0"/> <glyph class="state variable" id="_4ae18289-bdfb-4016-8ac0-bcd05c0fe79a"> <state value="" variable="P564"/> <bbox w="30.0" h="10.0" x="5881.095" y="7905.0"/> </glyph> <glyph class="state variable" id="_3805815e-8f60-4d75-b3d8-d0fd74be295f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5924.0684" y="7905.0"/> </glyph> <glyph class="state variable" id="_094a14a0-b8c6-4d38-a5c5-da497aea70de"> <state value="OH" variable="N803"/> <bbox w="40.0" h="10.0" x="5875.001" y="7945.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5679_sa1193"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: aryl hydrocarbon receptor nuclear translocator HUGO:ARNT HGNC:700 ENTREZ:405 UNIPROT:P27540 Identifiers_end Maps_Modules_begin: MODULE:GLUCOSE_METABOLISM MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:HIF1beta References_end </body> </html> </notes> <label text="HIF1B*"/> <bbox w="80.0" h="40.0" x="5872.5" y="7860.0"/> </glyph> </glyph> <glyph class="complex" id="s5680_csa131" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BMF:DYNLL2 Identifiers_end </body> </html> </notes> <label text="myosin V motor complex:BMF"/> <bbox w="100.0" h="120.0" x="3761.5" y="2826.25"/> <glyph class="macromolecule" id="s2505_sa1372"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Bcl2 modifying factor HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BMF"/> <bbox w="80.0" h="40.0" x="3769.5" y="2842.25"/> <glyph class="state variable" id="_5c519ae8-9c16-4882-ba71-ef5d3cdeeebf"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3818.5686" y="2837.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5681_sa1373"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dynein, light chain, LC8-type 2 HUGO:DYNLL2 HGNC:24596 ENTREZ:140735 UNIPROT:Q96FJ2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="DYNLL2"/> <bbox w="80.0" h="40.0" x="3769.5" y="2886.25"/> </glyph> </glyph> <glyph class="complex" id="s5688_csa348" compartmentRef="c12_ca14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CHUK:IKBKG:IKK_beta_* Identifiers_end </body> </html> </notes> <label text="IKK complex"/> <bbox w="98.0" h="176.0" x="6055.0" y="825.25"/> <glyph class="macromolecule" id="s5689_sa3239"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <bbox w="80.0" h="40.0" x="6064.0" y="834.25"/> </glyph> <glyph class="macromolecule" id="s4212_sa3240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:28462531 References_end </body> </html> </notes> <label text="IKKβ*"/> <bbox w="80.0" h="40.0" x="6064.0" y="884.25"/> <glyph class="state variable" id="_eeec476d-fcf0-4177-a202-870c149f4f1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6082.4316" y="879.25"/> </glyph> <glyph class="state variable" id="_c43262eb-4ab9-4dd3-be5c-c664d8ed2af6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6115.5684" y="879.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s5690_sa3241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: conserved helix-loop-helix ubiquitous kinase HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 IKBK-alpha synonym:IKBKA synonym:IKK_alpha_ Maps_Modules_end References_end </body> </html> </notes> <label text="CHUK"/> <bbox w="80.0" h="40.0" x="6064.0" y="932.25"/> </glyph> </glyph> <glyph class="complex" id="s5691_csa354" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:SKP1:_beta_TRCP* Identifiers_end </body> </html> </notes> <label text="SCF(bTrCP)_complex"/> <clone/> <bbox w="182.0" h="120.0" x="5743.5" y="1102.0"/> <glyph class="macromolecule" id="s5692_sa3303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: beta-transducin repeat containing E3 ubiquitin protein ligase HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 F-box and WD repeat domain containing 11 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:beta-TrCP1 synonym:beta-TrCP2 References_end </body> </html> </notes> <label text="βTRCP*"/> <clone/> <bbox w="80.0" h="40.0" x="5753.5" y="1112.0"/> </glyph> <glyph class="macromolecule" id="s5693_sa3304"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="CUL1"/> <clone/> <bbox w="80.0" h="40.0" x="5753.5" y="1156.0"/> </glyph> <glyph class="macromolecule" id="s5694_sa3305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <clone/> <bbox w="80.0" h="40.0" x="5835.5" y="1112.0"/> </glyph> <glyph class="macromolecule" id="s5695_sa3306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="SKP1"/> <clone/> <bbox w="80.0" h="40.0" x="5835.5" y="1156.0"/> </glyph> </glyph> <glyph class="complex" id="s5691_csa118" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:SKP1:_beta_TRCP* Identifiers_end </body> </html> </notes> <label text="SCF(bTrCP)_complex"/> <clone/> <bbox w="182.0" h="120.0" x="5058.0" y="2579.0"/> <glyph class="macromolecule" id="s5692_sa1294"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: beta-transducin repeat containing E3 ubiquitin protein ligase HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 F-box and WD repeat domain containing 11 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: synonym:beta-TrCP1 synonym:beta-TrCP2 References_end </body> </html> </notes> <label text="βTRCP*"/> <clone/> <bbox w="80.0" h="40.0" x="5068.0" y="2589.0"/> </glyph> <glyph class="macromolecule" id="s5693_sa1295"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="CUL1"/> <clone/> <bbox w="80.0" h="40.0" x="5068.0" y="2633.0"/> </glyph> <glyph class="macromolecule" id="s5694_sa1296"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <clone/> <bbox w="80.0" h="40.0" x="5150.0" y="2589.0"/> </glyph> <glyph class="macromolecule" id="s5695_sa1297"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="SKP1"/> <clone/> <bbox w="80.0" h="40.0" x="5150.0" y="2633.0"/> </glyph> </glyph> <glyph class="complex" id="s5696_csa356" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFKB1_p50*:RELA Identifiers_end </body> </html> </notes> <label text="RELA:p50"/> <bbox w="100.0" h="120.0" x="5352.5" y="1435.0"/> <glyph class="macromolecule" id="s5697_sa3310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: v-rel reticuloendotheliosis viral oncogene homolog A (avian) HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RELA"/> <bbox w="80.0" h="40.0" x="5364.0723" y="1488.4805"/> <glyph class="state variable" id="_2f80ac82-9650-49db-89df-0cb3cb8f2764"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5382.504" y="1523.4805"/> </glyph> <glyph class="state variable" id="_f9424a55-b7c6-4289-9a61-8cb3e75b47ec"> <state value="" variable="T254"/> <bbox w="30.0" h="10.0" x="5404.995" y="1523.4805"/> </glyph> </glyph> <glyph class="macromolecule" id="s5698_sa3311"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB1_p50*"/> <bbox w="80.0" h="40.0" x="5364.8223" y="1444.4805"/> <glyph class="unit of information" id="_e41dc1c9-b8b1-4097-bd69-caa556e27106"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="5379.8223" y="1439.4805"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5703_csa390" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase8,10*:DR4/5*:FADD:TRAIL* Identifiers_end References_begin: TRAIL*:FADD:DR4/5*:Caspase8,10* 20531300 19090789 References_end </body> </html> </notes> <label text="Caspase8,10*:FADD:TRAIL*:DR4/5*"/> <bbox w="220.0" h="197.5" x="7000.0" y="101.25"/> <glyph class="macromolecule" id="s5704_sa3859"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7100.0" y="108.75"/> </glyph> <glyph class="macromolecule" id="s5705_sa3860"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7100.0" y="153.75"/> <glyph class="state variable" id="_4e2f692d-7b99-439c-9f41-731ca029f6ce"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7130.0" y="198.75"/> </glyph> <glyph class="state variable" id="_e294b9e5-b460-4cd2-924d-9fed43ab285c"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7172.5" y="173.75"/> </glyph> <glyph class="unit of information" id="_cb91ddcb-53b5-4238-9ec9-a71e4cb7605e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7117.5" y="148.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5706_sa3861"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7020.0" y="153.75"/> </glyph> <glyph class="macromolecule" id="s5704_sa3862"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7110.0" y="118.75"/> </glyph> <glyph class="macromolecule" id="s5705_sa3863"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7110.0" y="163.75"/> <glyph class="state variable" id="_3273603b-b6f1-4b08-bbfb-45ee518a906c"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7140.0" y="208.75"/> </glyph> <glyph class="state variable" id="_7a933dbd-acdd-4ede-8577-7203c5ee7df2"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7182.5" y="183.75"/> </glyph> <glyph class="unit of information" id="_16ce4692-19ef-473d-99df-98f53d09d4df"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7127.5" y="158.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5706_sa3864"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7030.0" y="163.75"/> </glyph> <glyph class="macromolecule" id="s5704_sa3865"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7120.0" y="128.75"/> </glyph> <glyph class="macromolecule" id="s5705_sa3866"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7120.0" y="173.75"/> <glyph class="state variable" id="_81ebe343-8018-46b4-acec-11ebeca076ea"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7150.0" y="218.75"/> </glyph> <glyph class="state variable" id="_20458fa3-5dcb-4c41-a81d-26e6bf0a15f8"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7192.5" y="193.75"/> </glyph> <glyph class="unit of information" id="_fa3dc2c9-65cf-4792-8208-e6d9fef0bd32"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7137.5" y="168.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5706_sa3867"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7040.0" y="173.75"/> </glyph> <glyph class="macromolecule" id="s5707_sa3869"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7015.0" y="218.75"/> <glyph class="state variable" id="_d0c7ff6e-2b34-4989-bbb0-b2587cfe96b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7010.0" y="225.46573"/> </glyph> </glyph> <glyph class="macromolecule" id="s5707_sa3870"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7025.0" y="228.75"/> <glyph class="state variable" id="_2cd37f00-19d4-4d27-bbd7-28b3f80843ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7020.0" y="235.46573"/> </glyph> </glyph> <glyph class="macromolecule" id="s5707_sa3871"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7035.0" y="238.75"/> <glyph class="state variable" id="_07fde86f-34a7-4cb1-a666-d77b5619920e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7030.0" y="245.46573"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5708_csa392" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:Caspase8,10*:DR4/5*:FADD:RBX1:TRAIL* Identifiers_end References_begin: Caspase8,10*:FADD:TRAIL*:DR4/5*:RBX1:CUL3 20531300 caspase-8 is polyubiquitylated at the DISC in response to Apo2L/TRAIL 19090789 23845861 References_end </body> </html> </notes> <label text="Caspase8,10*:FADD:TRAIL*:DR4/5*"/> <bbox w="305.0" h="209.375" x="7297.5" y="95.3125"/> <glyph class="macromolecule" id="s5709_sa3882"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7482.5" y="102.8125"/> </glyph> <glyph class="macromolecule" id="s5710_sa3883"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7482.5" y="147.8125"/> <glyph class="state variable" id="_b42f0a20-2427-4d25-8c83-0a1138ce8108"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7512.5" y="192.8125"/> </glyph> <glyph class="state variable" id="_33a2fe12-dca5-412c-95cb-d3551720c40a"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7555.0" y="167.8125"/> </glyph> <glyph class="unit of information" id="_4a37e019-c216-401c-9fc2-c220dfba9cd9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7500.0" y="142.8125"/> </glyph> </glyph> <glyph class="macromolecule" id="s5711_sa3884"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7402.5" y="147.8125"/> </glyph> <glyph class="macromolecule" id="s5709_sa3885"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7492.5" y="112.8125"/> </glyph> <glyph class="macromolecule" id="s5710_sa3886"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7492.5" y="157.8125"/> <glyph class="state variable" id="_c13736e1-0f7f-4fa1-9d2d-434fa0880d69"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7522.5" y="202.8125"/> </glyph> <glyph class="state variable" id="_545809ba-4c55-4f97-9834-6a1b51c8a093"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7565.0" y="177.8125"/> </glyph> <glyph class="unit of information" id="_dffb33f0-4600-4a8b-809c-39be8325a54e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7510.0" y="152.8125"/> </glyph> </glyph> <glyph class="macromolecule" id="s5711_sa3887"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7412.5" y="157.8125"/> </glyph> <glyph class="macromolecule" id="s5709_sa3888"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor (ligand) superfamily, member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:9242610 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. PMID:8777713 Also known as APO2L, TNFSF10 References_end </body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="7502.5" y="122.8125"/> </glyph> <glyph class="macromolecule" id="s5710_sa3889"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: TRAIL receptor 1 and 2 PMID:20531300 PMID:19090789 PMID:9242610 References_end </body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="7502.5" y="167.8125"/> <glyph class="state variable" id="_40ff0e2f-a7a0-4cc3-94d1-0e71900e3236"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7532.5" y="212.8125"/> </glyph> <glyph class="state variable" id="_95a82815-00d7-4356-b620-60db33dca007"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="7575.0" y="187.8125"/> </glyph> <glyph class="unit of information" id="_7871d1b3-9dba-4a05-9087-3a15f44a3802"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7520.0" y="162.8125"/> </glyph> </glyph> <glyph class="macromolecule" id="s5711_sa3890"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7422.5" y="167.8125"/> </glyph> <glyph class="macromolecule" id="s5712_sa3891"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7397.5" y="212.8125"/> <glyph class="state variable" id="_deff3c30-7f8f-4f7c-9012-14a5b9585106"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7387.5" y="219.52823"/> </glyph> </glyph> <glyph class="macromolecule" id="s5712_sa3892"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7407.5" y="222.8125"/> <glyph class="state variable" id="_214d4c1c-18f3-4a84-9117-ee9810e10e07"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7397.5" y="229.52823"/> </glyph> </glyph> <glyph class="macromolecule" id="s5712_sa3893"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7417.5" y="232.8125"/> <glyph class="state variable" id="_6b2becad-14c7-41d4-9643-d9fe522aae7d"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7407.5" y="239.52823"/> </glyph> </glyph> <glyph class="macromolecule" id="s5174_sa3898"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="7307.5" y="184.6875"/> </glyph> <glyph class="macromolecule" id="s5175_sa3899"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="7307.5" y="224.6875"/> </glyph> </glyph> <glyph class="complex" id="s5716_csa412" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CFLAR:Caspase8,10*:FADD:FAF1:FAS:FASLG:FLASH*:MLKL:RIPK1:RIPK3 Identifiers_end References_begin: 10*:RIPK3:CFLAR:FLASH*:RIPK1:FAF1:FADD:MLKL:FASLG:FAS Fas Ligation can lead to Programmed necrosis 23069999 9217161 FLIPs and FLIP(L) interact with the adaptor protein FADD and the protease FLICE, and potently inhibit apoptosis induced by all known human death receptors 22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival 15592525 endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH References_end </body> </html> </notes> <label text="FAS:FASLG:FADD:DAXX:ASK1"/> <bbox w="415.0" h="176.25" x="7585.75" y="1157.125"/> <glyph class="macromolecule" id="s5397_sa4011"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="7703.75" y="1261.625"/> <glyph class="state variable" id="_d840eca6-622b-4b7e-8322-701c9a793dcb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7698.75" y="1267.7961"/> </glyph> <glyph class="state variable" id="_d5784f78-5846-49fd-8611-06108ae2f131"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="7768.75" y="1267.875"/> </glyph> <glyph class="state variable" id="_9e68c8a4-4b66-4a29-abb0-8d5cb5d69d6d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7741.5864" y="1256.625"/> </glyph> <glyph class="state variable" id="_f47382f6-630b-41e9-8a98-28b40ca14901"> <state value="P" variable="S161"/> <bbox w="35.0" h="10.0" x="7742.5806" y="1296.625"/> </glyph> </glyph> <glyph class="macromolecule" id="s5717_sa4014"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="7805.75" y="1209.625"/> </glyph> <glyph class="macromolecule" id="s6073_sa4018"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CASP8 and FADD-like apoptosis regulator HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:15760909 PMID:19838173 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce References_end </body> </html> </notes> <label text="CFLAR"/> <bbox w="80.0" h="40.0" x="7723.75" y="1169.625"/> <glyph class="state variable" id="_8796b800-bab8-446a-86a5-bd593db2be89"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7775.3184" y="1164.625"/> </glyph> </glyph> <glyph class="macromolecule" id="s5719_sa4024"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 associated protein 2 HUGO:CASP8AP2 HGNC:1510 ENTREZ:9994 UNIPROT:Q9UKL3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:22427918 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival PMID:12702723 PMID:15592525 PMID:1134007 References_end </body> </html> </notes> <label text="FLASH*"/> <bbox w="80.0" h="40.0" x="7725.75" y="1209.625"/> </glyph> <glyph class="macromolecule" id="s6298_sa4025"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7610.75" y="1209.625"/> <glyph class="state variable" id="_0ae87a8b-80e3-44a6-b03f-4264bc20a439"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7600.75" y="1216.3407"/> </glyph> </glyph> <glyph class="macromolecule" id="s6074_sa4026"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12702723 FAF1 is a member of Fas-DISC acting upstream of caspase-8 PMID:19597341 FAF1 downregulation may contribute to multiple aspects of tumorigenesis References_end </body> </html> </notes> <label text="FAF1"/> <bbox w="80.0" h="40.0" x="7805.75" y="1167.625"/> </glyph> <glyph class="macromolecule" id="s6300_sa4040"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: receptor-interacting serine-threonine kinase 3 HUGO:RIPK3 HGNC:10021 ENTREZ:11035 UNIPROT:Q9Y572 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:23010170 PMID:27558815 PMID:23073834 PMID:19524512 PMID:19632174 PMID:19498109 PMID:19524513 The kinase activity of RIP3 is essential for necrosis execution. PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. PMID:26900751 CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. References_end </body> </html> </notes> <label text="RIPK3"/> <bbox w="80.0" h="40.0" x="7608.75" y="1265.375"/> <glyph class="state variable" id="_580dec88-95d3-4fe1-aa9d-3df87dea41d7"> <state value="" variable="S227"/> <bbox w="30.0" h="10.0" x="7594.2427" y="1260.375"/> </glyph> <glyph class="state variable" id="_b5dcd799-ffe0-466b-97af-0daf402426f6"> <state value="P" variable="S199"/> <bbox w="35.0" h="10.0" x="7648.199" y="1260.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s5344_sa4041"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mixed lineage kinase domain-like HUGO:MLKL HGNC:26617 ENTREZ:197259 UNIPROT:Q8NB16 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 PMID:24366341 PMID:26024392 PMID:26853145 Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. PMID:28498367 References_end </body> </html> </notes> <label text="MLKL"/> <bbox w="80.0" h="40.0" x="7798.75" y="1265.375"/> <glyph class="state variable" id="_e987fcca-c804-46e1-a301-eda9fea69c8e"> <state value="" variable="T357"/> <bbox w="30.0" h="10.0" x="7783.75" y="1271.8816"/> </glyph> <glyph class="state variable" id="_4ff0310c-d4bd-4047-9f78-ff30a91ce06b"> <state value="" variable="S358"/> <bbox w="30.0" h="10.0" x="7807.345" y="1260.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s5722_sa4079"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7889.5" y="1176.75"/> </glyph> <glyph class="macromolecule" id="s5723_sa4080"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7892.5" y="1221.75"/> <glyph class="state variable" id="_5937c9a8-6e5f-4def-9bcb-b69f27ed8bdc"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7962.5" y="1231.3947"/> </glyph> <glyph 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7902.5" y="1231.75"/> <glyph class="state variable" id="_03c71c4d-a725-432e-9a77-bb7e6bcb3f01"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7972.5" y="1241.3947"/> </glyph> <glyph class="unit of information" id="_3102d04b-fa5c-4756-93b8-047feac81234"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7920.0" y="1226.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s5722_sa4083"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="7909.5" y="1196.75"/> </glyph> <glyph class="macromolecule" id="s5723_sa4084"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7912.5" y="1241.75"/> <glyph class="state variable" id="_6dd9bff8-cd91-446b-9351-0d0251939f8e"> <state value="Pa" variable=""/> <bbox w="20.0" h="10.0" x="7982.5" y="1251.3947"/> </glyph> <glyph class="unit of information" id="_7063fc2d-4a0b-4c06-808a-9bdaae8df4d5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7930.0" y="1236.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5724_csa417" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APPL2:Caspase9*:Cleaved DCC* Identifiers_end References_begin: DCC*:APPL2:Caspase9* 11248093 DCC interacts with caspase-9 and drives the activation of caspase-3 through caspase-9 References_end </body> </html> </notes> <label text="DCC:NTN1"/> <bbox w="100.0" h="170.0" x="1588.0514" y="189.4311"/> <glyph class="macromolecule" id="s5952_sa4120"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 HUGO:APPL2 HGNC:18242 ENTREZ:55198 UNIPROT:Q8NEU8 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12011067 DIP13 alpha is a mediator of the DCC apoptotic pathway PMID:22920895 References_end </body> </html> </notes> <label text="APPL2"/> <bbox w="80.0" h="40.0" x="1598.0514" y="249.4311"/> </glyph> <glyph class="macromolecule" id="s5953_sa4124"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="1598.0514" y="299.4311"/> <glyph class="state variable" id="_3e228904-a2ef-46ca-a750-c470a60604f6"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="1606.6464" y="294.4311"/> </glyph> <glyph class="state variable" id="_5ec0947c-b6a7-4c05-a3ce-300b0f0c05f2"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="1640.0007" y="294.4311"/> </glyph> <glyph class="state variable" id="_d504ef3f-cc2b-4087-835d-04c368e5bd4e"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="1639.382" y="334.4311"/> </glyph> <glyph class="state variable" id="_790ab5b1-764e-4623-be57-ea566f55ae4c"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="1606.0269" y="334.4311"/> </glyph> <glyph class="state variable" id="_6027cb77-fe3b-4716-98c8-74e01ee46279"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="1665.5514" y="314.4311"/> </glyph> <glyph class="state variable" 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</glyph> <glyph class="macromolecule" id="s5737_sa4145" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: KIAA1524 HUGO:KIAA1524 HGNC:29302 ENTREZ:57650 UNIPROT:Q8TCG1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21172653 CIP2A is an inhibitor of UNC5H2/B-induced DAPk activation References_end </body> </html> </notes> <label text="CIP2A*"/> <bbox w="80.0" h="40.0" x="2078.0515" y="449.4311"/> </glyph> <glyph class="complex" id="s5741_csa423" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP2CB:PPPR1B Identifiers_end References_begin: 21172653 References_end </body> </html> </notes> <label text="PP2A"/> <bbox w="100.0" h="120.0" x="1968.0514" y="409.4311"/> <glyph class="macromolecule" id="s5735_sa4141"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21172653 subunit PR65β of the holoenzyme protein phosphatase 2A (PP2A) References_end </body> </html> </notes> <label text="PPPR1B"/> <bbox w="80.0" h="40.0" x="1978.0514" y="429.4311"/> </glyph> <glyph class="macromolecule" id="s5736_sa4142"> <notes> <html 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Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase D1 HUGO:PRKD1 HGNC:9407 ENTREZ:5587 UNIPROT:Q15139 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17496911 PMID:17703233 DAPk activates PKD References_end </body> </html> </notes> <label text="PRKD1"/> <bbox w="80.0" h="40.0" x="2198.0515" y="419.4311"/> <glyph class="state variable" id="_7f217cd0-f92b-4173-9480-9049baef67f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2249.62" y="414.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5753_sa4158" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase D1 HUGO:PRKD1 HGNC:9407 ENTREZ:5587 UNIPROT:Q15139 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17496911 PMID:17703233 DAPk activates PKD References_end </body> </html> </notes> <label text="PRKD1"/> <bbox w="80.0" h="40.0" x="2400.0" y="420.0"/> <glyph class="state variable" id="_eecbce56-b033-4b46-b01c-419991415616"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2449.0686" y="415.0"/> </glyph> </glyph> <glyph class="complex" id="s5762_csa426" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NTN1:UNC5A Identifiers_end References_begin: 19543238 Netrin-1 triggers the multimerization of UNC5H2 receptors, and that multimerization of the intracellular domain of UNC5H2 is the critical step to inhibit proapoptotic effects References_end </body> </html> </notes> <label text="multimerize UNC5H1:NTN1"/> <bbox w="110.0" h="125.0" x="2398.0515" y="129.4311"/> <glyph class="macromolecule" id="s5764_sa4163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <bbox w="80.0" h="40.0" x="2408.0515" y="134.4311"/> </glyph> <glyph class="macromolecule" id="s5763_sa4164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog A (C. elegans) HUGO:UNC5A HGNC:12567 ENTREZ:90249 UNIPROT:Q6ZN44 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:18582460 PMID:20173780 PMID:16829956 UNC5A promotes neuronal apoptosis References_end </body> </html> </notes> <label text="UNC5A"/> <bbox w="80.0" h="50.0" x="2408.0515" y="179.4311"/> <glyph class="unit of information" id="_767eeb78-3c11-472c-911c-5e77ab7ec56a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2425.5515" y="174.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5764_sa4165"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: netrin 1 HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:20173780 PMID:19543238 PMID:22920895 Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H References_end </body> </html> </notes> <label text="NTN1"/> <bbox w="80.0" h="40.0" x="2418.0515" y="144.4311"/> </glyph> <glyph class="macromolecule" id="s5763_sa4166"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog A (C. elegans) HUGO:UNC5A HGNC:12567 ENTREZ:90249 UNIPROT:Q6ZN44 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:18582460 PMID:20173780 PMID:16829956 UNC5A promotes neuronal apoptosis References_end </body> </html> </notes> <label text="UNC5A"/> <bbox w="80.0" h="50.0" x="2418.0515" y="189.4311"/> <glyph class="unit of information" id="_730057d4-a1fd-4075-aad4-13891f6de326"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2435.5515" y="184.4311"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5770_csa428" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NRAGE*:XIAP Identifiers_end References_begin: 11546791 NRAGE may act to sequester and inactivate XIAP protein References_end </body> </html> </notes> <label text="NRAGE:XIAP"/> <clone/> <bbox w="100.0" h="120.0" x="2728.0515" y="279.4311"/> <glyph class="macromolecule" id="s5771_sa4167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="2738.0515" y="289.4311"/> <glyph class="state variable" id="_d736d203-fcc8-47c6-a1c0-9ad8de2f1ff6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2756.483" y="284.4311"/> </glyph> <glyph class="state variable" id="_e2ac1338-58ff-4219-988b-5dac9b7d2f10"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="2782.5007" y="284.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5769_sa4170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <clone/> <bbox w="80.0" h="40.0" x="2738.0515" y="329.4311"/> </glyph> </glyph> <glyph class="complex" id="s5770_csa435" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NRAGE*:XIAP Identifiers_end References_begin: 11546791 NRAGE may act to sequester and inactivate XIAP protein References_end </body> </html> </notes> <label text="NRAGE:XIAP"/> <clone/> <bbox w="100.0" h="120.0" x="3310.0" y="540.0"/> <glyph class="macromolecule" id="s5771_sa4228"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="3320.0" y="550.0"/> <glyph class="state variable" id="_4b33f04a-9415-43dc-a7ff-29da5207d79b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3338.4314" y="545.0"/> </glyph> <glyph class="state variable" id="_2188372a-c906-4289-bc22-f894d030ba8e"> <state value="" variable="S87"/> <bbox w="25.0" h="10.0" x="3364.4492" y="545.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5769_sa4229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <clone/> <bbox w="80.0" h="40.0" x="3320.0" y="590.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5772_sa4172" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-5 homolog A (C. elegans) HUGO:UNC5A HGNC:12567 ENTREZ:90249 UNIPROT:Q6ZN44 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:18582460 PMID:20173780 PMID:16829956 UNC5A promotes neuronal apoptosis References_end </body> </html> </notes> <label text="UNC5A"/> <bbox w="80.0" h="50.0" x="2698.0515" y="184.4311"/> <glyph class="unit of information" id="_c6e8d5e0-6aa2-4d26-8370-6540891f7f48"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2715.5515" y="179.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5774_sa4174" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase recruitment domain family, member 8 HUGO:CARD8 HGNC:17057 ENTREZ:22900 UNIPROT:Q9Y2G2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:19465923 PMID:11408476 TUCAN was proposed to function as an adaptor protein for caspase-9 References_end </body> </html> </notes> <label text="TUCAN*"/> <bbox w="80.0" h="40.0" x="2910.0" y="330.0"/> </glyph> <glyph class="macromolecule" id="s5775_sa4175" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, pyrin domain containing 1 HUGO:NLRP1 HGNC:14374 ENTREZ:22861 UNIPROT:Q9C000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19465923 Ptc–DRAL interaction represents an anchor for a specific TUCAN/NALP1-caspase-9-containing complex References_end </body> </html> </notes> <label text="NLRP1"/> <clone/> <bbox w="80.0" h="40.0" x="2910.0" y="370.0"/> <glyph class="unit of information" id="_08d09d9d-65ef-49b4-a29f-a4b201700b6d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2927.5" y="365.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5775_sa5395" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, pyrin domain containing 1 HUGO:NLRP1 HGNC:14374 ENTREZ:22861 UNIPROT:Q9C000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19465923 Ptc–DRAL interaction represents an anchor for a specific TUCAN/NALP1-caspase-9-containing complex References_end </body> </html> </notes> <label text="NLRP1"/> <clone/> <bbox w="80.0" h="50.0" x="10140.0" y="525.0"/> <glyph class="unit of information" id="_f785a886-2010-4f2a-8521-e2b0c7a82b0e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10157.5" y="520.0"/> </glyph> </glyph> <glyph class="complex" id="s5776_csa429" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DRAL*:NEDD4:NLRP1:PTCH*:TUCAN* Identifiers_end References_begin: 22679284 in the absence of Shh, Ptc recruits a protein complex that includes DRAL, one of the caspase recruitment (CARD)-domain containing proteins TUCAN (family member, 8) or NALP1 (NLR family, pyrin domain containing 1) and apical caspase-9 References_end </body> </html> </notes> <label text="DRAL:TUCAN*:NLRP1:Caspase9*:Patched"/> <bbox w="100.0" h="250.0" x="3070.0" y="180.0"/> <glyph class="macromolecule" id="s5789_sa4184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase HUGO:NEDD4 HGNC:7727 ENTREZ:4734 UNIPROT:P46934 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22679284 Ptc allows the activation of caspase-9 via its ubiquitination, which occurs via the recruitment by Ptc of NEDD4. References_end </body> </html> </notes> <label text="NEDD4"/> <bbox w="80.0" h="40.0" x="3080.0" y="360.0"/> </glyph> <glyph class="macromolecule" id="s5782_sa4181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: four and a half LIM domains 2 HUGO:FHL2 HGNC:3703 ENTREZ:2274 UNIPROT:Q14192 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:19465923 DRAL is required for the pro-apoptotic activity of Ptc References_end </body> </html> </notes> <label text="DRAL*"/> <bbox w="80.0" h="40.0" x="3080.0" y="240.0"/> </glyph> <glyph class="macromolecule" id="s5778_sa4178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase recruitment domain family, member 8 HUGO:CARD8 HGNC:17057 ENTREZ:22900 UNIPROT:Q9Y2G2 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:19465923 PMID:11408476 TUCAN was proposed to function as an adaptor protein for caspase-9 References_end </body> </html> </notes> <label text="TUCAN*"/> <bbox w="80.0" h="40.0" x="3080.0" y="280.0"/> </glyph> <glyph class="macromolecule" id="s5779_sa4177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NLR family, pyrin domain containing 1 HUGO:NLRP1 HGNC:14374 ENTREZ:22861 UNIPROT:Q9C000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19465923 Ptc–DRAL interaction represents an anchor for a specific TUCAN/NALP1-caspase-9-containing complex References_end </body> </html> </notes> <label text="NLRP1"/> <bbox w="80.0" h="40.0" x="3080.0" y="320.0"/> <glyph class="unit of information" id="_2e06607e-be73-4f35-bf4d-77af4067c7da"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3097.5" y="315.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5777_sa4173"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:19465923 PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9 References_end </body> </html> </notes> <label text="PTCH*"/> <bbox w="80.0" h="50.0" x="3080.0" y="185.0"/> <glyph class="unit of information" id="_b92574ca-fa8c-4290-8613-b37d58a47a0c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3097.5" y="180.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s5781_sa4180" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: four and a half LIM domains 2 HUGO:FHL2 HGNC:3703 ENTREZ:2274 UNIPROT:Q14192 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:19465923 DRAL is required for the pro-apoptotic activity of Ptc References_end </body> </html> </notes> <label text="DRAL*"/> <bbox w="80.0" h="40.0" x="2910.0" y="290.0"/> </glyph> <glyph class="complex" id="s5785_csa430" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PTCH*:SHH Identifiers_end References_begin: 20495383 In the absence of SHH; Patched recruits a dral-tucan complex that lead to apoptosis References_end </body> </html> </notes> <label text="Patched:SHH"/> <bbox w="100.0" h="130.0" x="2800.0" y="130.0"/> <glyph class="macromolecule" id="s5786_sa4182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sonic hedgehog HUGO:SHH HGNC:10848 ENTREZ:6469 UNIPROT:Q15465 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 In the absence of SHH; Patched recruits a dral-tucan complex that lead to apoptosis References_end </body> </html> </notes> <label text="SHH"/> <bbox w="80.0" h="40.0" x="2810.0" y="140.0"/> </glyph> <glyph class="macromolecule" id="s5787_sa4183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:19465923 PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9 References_end </body> </html> </notes> <label text="PTCH*"/> <bbox w="80.0" h="50.0" x="2810.0" y="185.0"/> <glyph class="unit of information" id="_2b5fd8ab-d7ea-48b2-9414-946c7116f9fb"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2827.5" y="180.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s5788_sa4185" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase HUGO:NEDD4 HGNC:7727 ENTREZ:4734 UNIPROT:P46934 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22679284 Ptc allows the activation of caspase-9 via its ubiquitination, which occurs via the recruitment by Ptc of NEDD4. References_end </body> </html> </notes> <label text="NEDD4"/> <bbox w="80.0" h="40.0" x="2910.0" y="410.0"/> </glyph> <glyph class="macromolecule" id="s5790_sa4179" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:19465923 The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. References_end </body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="3170.0" y="510.0"/> <glyph class="state variable" id="_c6edf3ed-2060-42a2-9df7-aadb4f003bb0"> <state value="" variable="T125"/> <bbox w="30.0" h="10.0" x="3178.595" y="505.0"/> </glyph> <glyph class="state variable" id="_c71b7413-8123-43d3-b450-037be8ff3edf"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="3211.9492" y="505.0"/> </glyph> <glyph class="state variable" id="_e829ceab-7155-40c3-ad51-4acdd97d1d33"> <state value="" variable="Y153"/> <bbox w="30.0" h="10.0" x="3211.3306" y="545.0"/> </glyph> <glyph class="state variable" id="_0cd38f2d-12a3-4364-814f-d9a2fec9e14b"> <state value="" variable="S144"/> <bbox w="30.0" h="10.0" x="3177.9756" y="545.0"/> </glyph> <glyph class="state variable" id="_eb40d5f2-f142-49e5-9613-57c5ae6555f0"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="3232.5" y="525.0"/> </glyph> <glyph class="state variable" id="_d70edae6-8bdf-40d6-809f-751e13d0a86c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3165.0" y="525.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5791_sa4186" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <clone/> <bbox w="80.0" h="40.0" x="3690.0" y="290.0"/> </glyph> <glyph class="macromolecule" id="s5791_sa4230" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <clone/> <bbox w="80.0" h="40.0" x="3580.0" y="550.0"/> </glyph> <glyph class="macromolecule" id="s5791_sa4237" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <clone/> <bbox w="80.0" h="40.0" x="3040.0" y="880.0"/> </glyph> <glyph class="simple chemical" id="s5796_sa4188" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16618 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 References_end </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="3305.0" y="377.5"/> </glyph> <glyph class="simple chemical" id="s5797_sa4189" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18348 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 References_end </body> </html> </notes> <label text="PIP2*"/> <bbox w="70.0" h="25.0" x="3185.0" y="377.5"/> </glyph> <glyph class="macromolecule" id="s5798_sa4204" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:24036369 I3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), in a reaction that can be reversed by the PIP3 phosphatase PTEN PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="PI3K*"/> <bbox w="80.0" h="40.0" x="3350.0" y="310.0"/> </glyph> <glyph class="macromolecule" id="s5799_sa4193" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: insulin receptor substrate 1 HUGO:IRS1 HGNC:6125 ENTREZ:3667 UNIPROT:P35568 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:24036369 PMID:22465479 Activated receptor tyrosine kinases (RTKs) activate class I phosphatidylinositol 3-kinase (PI3K) through direct binding or through tyrosine phosphorylation of scaffolding adaptors, such as IRS1, which then bind and activate PI3K References_end </body> </html> </notes> <label text="IRS1"/> <bbox w="80.0" h="40.0" x="3350.0" y="260.0"/> <glyph class="state variable" id="_68ee0d8e-d520-4408-9228-333af7a22669"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3401.5686" y="255.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5804_sa4198" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:22465479 The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. 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References_end </body> </html> </notes> <label text="NRIF*"/> <clone/> <bbox w="80.0" h="40.0" x="3690.0" y="340.0"/> <glyph class="state variable" id="_420b73ac-7870-4886-8ff9-fe5a3e6757ef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3741.5686" y="335.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5826_sa4244" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: integrin beta 3 binding protein (beta3-endonexin) HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. References_end </body> </html> </notes> <label text="NRIF*"/> <clone/> <bbox w="80.0" h="40.0" x="4160.0" y="560.0"/> <glyph class="state variable" id="_46934bf2-e787-4a4a-8b52-c670e8cb4d4f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4211.5684" y="555.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5827_sa4220" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nerve growth factor receptor (TNFRSF16) associated protein 1 HUGO:NGFRAP1 HGNC:13388 ENTREZ:27018 UNIPROT:Q00994 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:10764727 NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. References_end </body> </html> </notes> <label text="NADE*"/> <bbox w="80.0" h="40.0" x="3690.0" y="390.0"/> </glyph> <glyph class="macromolecule" id="s5838_sa4233" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis antagonizing transcription factor HUGO:AATF HGNC:19235 ENTREZ:26574 UNIPROT:Q9NY61 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. References_end </body> </html> </notes> <label text="AATF"/> <bbox w="80.0" h="40.0" x="3760.0" y="460.0"/> </glyph> <glyph class="source and sink" id="s5839_sa4234" compartmentRef="c1_ca1"> <label text="s5839"/> <bbox w="30.0" h="30.0" x="3885.0" y="465.0"/> </glyph> <glyph class="macromolecule" id="s5847_sa4238" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Rho guanine nucleotide exchange factor (GEF) 1 HUGO:ARHGEF1 HGNC:681 ENTREZ:9138 UNIPROT:Q92888 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21893191 PMID:10985348 References_end </body> </html> </notes> <label text="GEF*"/> <bbox w="80.0" h="40.0" x="3040.0" y="930.0"/> </glyph> <glyph class="macromolecule" id="s5848_sa3653" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: JNK1, SAPK1 PMID:23850759 PMID:18191217 PMID:26587781 synonym:JNK1 PMID:17603935 PMID:19037093 References_end </body> </html> </notes> <label text="JNK1*"/> <clone/> <bbox w="80.0" h="40.0" x="4210.0" y="1877.0"/> <glyph class="state variable" id="_92a4b67c-2acc-41cf-aacd-70a463cc4bd4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4225.9316" y="1872.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5848_sa4727" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: JNK1, SAPK1 PMID:23850759 PMID:18191217 PMID:26587781 synonym:JNK1 PMID:17603935 PMID:19037093 References_end </body> </html> </notes> <label text="JNK1*"/> <clone/> <bbox w="80.0" h="40.0" x="9670.0" y="5480.0"/> <glyph class="state variable" id="_5974a798-1f09-4b02-8df2-cf06f095ee4d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9685.932" y="5475.0"/> </glyph> </glyph> <glyph class="complex" id="s5853_csa437" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APH1A:APH1B Identifiers_end References_begin: 16630834 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons References_end </body> </html> </notes> <label text="Gamma-secretase complex"/> <bbox w="100.0" h="120.0" x="3950.0" y="350.0"/> <glyph class="macromolecule" id="s5857_sa4241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: APH1A gamma secretase subunit HUGO:APH1A HGNC:29509 ENTREZ:51107 UNIPROT:Q96BI3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16630834 References_end </body> </html> </notes> <label text="APH1A"/> <bbox w="80.0" h="40.0" x="3960.0" y="360.0"/> </glyph> <glyph class="macromolecule" id="s5858_sa4242"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: APH1B gamma secretase subunit HUGO:APH1B HGNC:24080 ENTREZ:83464 UNIPROT:Q8WW43 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16630834 References_end </body> </html> </notes> <label text="APH1B"/> <bbox w="80.0" h="40.0" x="3960.0" y="400.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5860_sa4245" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: integrin beta 3 binding protein (beta3-endonexin) HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. References_end </body> </html> </notes> <label text="NRIF*"/> <bbox w="80.0" h="40.0" x="4000.0" y="560.0"/> <glyph class="state variable" id="_677bd87c-e33c-4177-b5b1-2e3ac79df0e2"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4046.5686" y="555.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5867_sa4258" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="cleaved Caspase2*"/> <bbox w="130.0" h="40.0" x="3785.0" y="870.0"/> <glyph class="unit of information" id="_ca660347-26ca-43c9-92a0-0f4292f976d4"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3825.0" y="865.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5871_sa4262" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cell division cycle 42 HUGO:CDC42 HGNC:1736 ENTREZ:998 UNIPROT:P60953 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDC42"/> <clone/> <bbox w="80.0" h="40.0" x="2852.0" y="641.0"/> </glyph> <glyph class="macromolecule" id="s5871_sa4568" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cell division cycle 42 HUGO:CDC42 HGNC:1736 ENTREZ:998 UNIPROT:P60953 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDC42"/> <clone/> <bbox w="80.0" h="40.0" x="2048.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s5872_sa4263" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="GTP binding protein*"/> <bbox w="127.0" h="36.0" x="2992.0" y="622.5"/> </glyph> <glyph class="macromolecule" id="s5885_sa4273" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas apoptotic inhibitory molecule HUGO:FAIM HGNC:18703 ENTREZ:55179 UNIPROT:Q9NVQ4 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE Maps_Modules_end References_begin: PMID:17942717 The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis FAIM(L) can bind to Fas receptor and prevent the activation of the initiator caspase-8 induced by Fas References_end </body> </html> </notes> <label text="FAIM"/> <bbox w="80.0" h="40.0" x="8080.0" y="540.0"/> </glyph> <glyph class="macromolecule" id="s5886_sa4274" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:17496911 References_end </body> </html> </notes> <label text="MAP3K1"/> <bbox w="80.0" h="40.0" x="4739.5" y="1742.0"/> <glyph class="state variable" id="_1c557235-c508-4c8e-8e31-1977a78c9f7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4791.0684" y="1737.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5887_sa3172" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 7 HUGO:MAP2K7 HGNC:6847 ENTREZ:5609 UNIPROT:O14733 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:MKK7 PMID:17496911 References_end </body> </html> </notes> <label text="MAP2K7"/> <bbox w="80.0" h="40.0" x="5098.5" y="1862.0"/> <glyph class="state variable" id="_7d0ec5c1-8846-4c7a-ac39-ef9b7308eabf"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5147.5684" y="1857.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5888_sa4276" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:17496911 References_end </body> </html> </notes> <label text="MAP3K1"/> <bbox w="80.0" h="40.0" x="4889.5" y="1742.0"/> <glyph class="state variable" id="_85d7d55a-72ce-4b6e-9d37-b5aedffe6365"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4938.5684" y="1737.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s5924_sa809" compartmentRef="c1_ca1"> <label text="Mg2+"/> <clone/> <bbox w="25.0" h="25.0" x="1639.0" y="990.6896"/> </glyph> <glyph class="simple chemical" id="s5924_sa2286" compartmentRef="c1_ca1"> <label text="Mg2+"/> <clone/> <bbox w="25.0" h="25.0" x="11497.5" y="1377.5"/> </glyph> <glyph class="simple chemical" id="s5925_sa4284" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18075 Identifiers_end </body> </html> </notes> <label text="dTDP"/> <bbox w="70.0" h="25.0" x="2125.0" y="2837.5"/> </glyph> <glyph class="simple chemical" id="s5926_sa4285" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28846 Identifiers_end </body> </html> </notes> <label text="dCDP"/> <bbox w="70.0" h="25.0" x="2205.0" y="2837.5"/> </glyph> <glyph class="macromolecule" id="s5928_sa3512" compartmentRef="c16_ca16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: family with sequence similarity 175, member A HUGO:FAM175A HGNC:25829 ENTREZ:84142 UNIPROT:Q6UWZ7 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:Abraxas synonym:ABRA1 synonym:CCDC98 References_end </body> </html> </notes> <label text="FAM175A"/> <bbox w="80.0" h="40.0" x="932.5" y="7455.0"/> </glyph> <glyph class="macromolecule" id="s5930_sa3503" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:Ubc13 References_end </body> </html> </notes> <label text="UBE2N"/> <clone/> <bbox w="80.0" h="40.0" x="1550.0" y="7670.0"/> </glyph> <glyph class="macromolecule" id="s5930_sa3504" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:Ubc13 References_end </body> </html> </notes> <label text="UBE2N"/> <clone/> <bbox w="80.0" h="40.0" x="1550.0" y="7720.0"/> </glyph> <glyph class="complex" id="s5955_csa427" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NRAGE*:UNC5A Identifiers_end References_begin: 16829956 In absence of his lignant, UNC5A is associated with NRAGE also called MAGE-D1 References_end </body> </html> </notes> <label text="NRAGE*:UNC5A"/> <bbox w="100.0" h="120.0" x="2588.0515" y="179.4311"/> <glyph class="macromolecule" id="s5765_sa4102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog A (C. elegans) HUGO:UNC5A HGNC:12567 ENTREZ:90249 UNIPROT:Q6ZN44 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:18582460 PMID:20173780 PMID:16829956 UNC5A promotes neuronal apoptosis References_end </body> </html> </notes> <label text="UNC5A"/> <bbox w="80.0" h="50.0" x="2598.0515" y="184.4311"/> <glyph class="unit of information" id="_47ac5a18-dec0-449b-a2b2-b1298e59d9ca"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2615.5515" y="179.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5755_sa4160"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <bbox w="80.0" h="40.0" x="2598.0515" y="239.4311"/> </glyph> </glyph> <glyph class="complex" id="s5956_csa422" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAPK1:PPP2CB:PPPR1B:UNC5B Identifiers_end References_begin: 21172653 in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation 21172648 References_end </body> </html> </notes> <label text="UNC5B:DAPK1:PPPR1B:PPP2CB"/> <bbox w="100.0" h="220.0" x="2088.0515" y="179.4311"/> <glyph class="macromolecule" id="s5745_sa4135"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: death-associated protein kinase 1 HUGO:DAPK1 HGNC:2674 ENTREZ:1612 UNIPROT:P53355 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17703233 DAP kinase regulates JNK signaling by binding and activating protein kinase D References_end </body> </html> </notes> <label text="DAPK1"/> <bbox w="80.0" h="40.0" x="2098.0515" y="239.4311"/> <glyph class="state variable" id="_99007f8f-f15a-4195-9c97-f9006809e571"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2116.483" y="234.4311"/> </glyph> <glyph class="state variable" id="_a5239299-f22d-454a-ae3d-24c961bb3352"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="2139.62" y="234.4311"/> </glyph> </glyph> <glyph class="macromolecule" id="s5746_sa4144"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21172653 subunit PR65β of the holoenzyme protein phosphatase 2A (PP2A) References_end </body> </html> </notes> <label text="PPPR1B"/> <bbox w="80.0" h="40.0" x="2098.0515" y="289.4311"/> </glyph> <glyph class="macromolecule" id="s5747_sa4146"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 2, catalytic subunit, beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21172653 subunit PR65β of the holoenzyme protein phosphatase 2A (PP2A) References_end </body> </html> </notes> <label text="PPP2CB"/> <bbox w="80.0" h="40.0" x="2098.0515" y="329.4311"/> </glyph> <glyph class="macromolecule" id="s5748_sa4154"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog B (C. elegans) HUGO:UNC5B HGNC:12568 ENTREZ:219699 UNIPROT:Q8IZJ1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:20495383 PMID:19543238 PMID:12598906 p53RDL1 mediated p53-dependent apoptosis. Conversely, when p53RDL1 interacted with its ligand, Netrin-1, p53-dependent apoptosis was blocked PMID:18582460 References_end </body> </html> </notes> <label text="UNC5B"/> <bbox w="80.0" h="50.0" x="2098.0515" y="184.4311"/> <glyph class="unit of information" id="_23778104-67a5-4a4f-af8d-94f10eb7b90e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2115.5515" y="179.4311"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5957_csa425" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAPK1:UNC5B-DD* Identifiers_end </body> </html> </notes> <label text="DAPK1:UNC5B-DD*"/> <bbox w="100.0" h="120.0" x="2290.0" y="280.0"/> <glyph class="macromolecule" id="s5729_sa4151"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: death-associated protein kinase 1 HUGO:DAPK1 HGNC:2674 ENTREZ:1612 UNIPROT:P53355 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17703233 DAP kinase regulates JNK signaling by binding and activating protein kinase D References_end </body> </html> </notes> <label text="DAPK1"/> <bbox w="80.0" h="40.0" x="2300.0" y="290.0"/> <glyph class="state variable" id="_0ca6de6d-cbfe-485a-bb5f-d174f0231bc5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2318.4314" y="285.0"/> </glyph> <glyph class="state variable" id="_fa3b92b4-ffe8-415e-9721-12b9a1c01b3a"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="2341.5686" y="285.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5749_sa4155"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-5 homolog B (C. elegans) HUGO:UNC5B HGNC:12568 ENTREZ:219699 UNIPROT:Q8IZJ1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21172648 conformational changes of UNC5B death-domain enables binding of the PR65b subunit of PP2A References_end </body> </html> </notes> <label text="UNC5B-DD*"/> <bbox w="80.0" h="40.0" x="2300.0" y="340.0"/> </glyph> </glyph> <glyph class="complex" id="s5959_csa439" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NRIF*:SQSTM1:TRAF6 Identifiers_end References_begin: 16252010 NRIF undergoes K63 polyubiquitination, associates with TRAF6 and p62, and translocates to the nucleus References_end </body> </html> </notes> <label text="NRIF*:SQSTM1:TRAF6"/> <bbox w="100.0" h="187.5" x="3990.0" y="732.5"/> <glyph class="macromolecule" id="s5865_sa4246"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> PMID: 16252010 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="4000.0" y="800.0"/> <glyph class="state variable" id="_87fe2325-3a0b-4c4f-9e8d-ff4b9fa8ffc4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4018.4314" y="795.0"/> </glyph> <glyph class="state variable" id="_a07508bb-8f01-42dc-9843-572052489175"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4051.5686" y="795.0"/> </glyph> <glyph class="state variable" id="_094ffeb3-96b1-494c-8267-e462532023c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4035.0" y="835.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5866_sa4248"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: integrin beta 3 binding protein (beta3-endonexin) HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. References_end </body> </html> </notes> <label text="NRIF*"/> <bbox w="80.0" h="40.0" x="4000.0" y="747.5"/> <glyph class="state variable" id="_c9ea8199-ec39-4484-ba01-7c71a12e4b85"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4046.5686" y="742.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s5958_sa4296"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor-associated factor 6, E3 ubiquitin protein ligase HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16252010 References_end </body> </html> </notes> <label text="TRAF6"/> <bbox w="80.0" h="40.0" x="4000.0" y="860.0"/> </glyph> </glyph> <glyph class="complex" id="s5960_csa438" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NGFR-ICD*:NRIF*:TRAF6 Identifiers_end References_begin: 15548667 15721744 16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation References_end </body> </html> </notes> <label text="NGFR-ICD*:NRIF*:TRAF6"/> <bbox w="100.0" h="185.0" x="4070.0" y="265.0"/> <glyph class="macromolecule" id="s5855_sa4239"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: integrin beta 3 binding protein (beta3-endonexin) HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. References_end </body> </html> </notes> <label text="NRIF*"/> <bbox w="80.0" h="40.0" x="4080.0" y="325.0"/> <glyph class="state variable" id="_b75b9180-28ae-43c5-b3a1-e6f23a0d6d7d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4131.5684" y="320.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5856_sa4240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor receptor HUGO:NGFR HGNC:7809 ENTREZ:4804 UNIPROT:P08138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16630834 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons References_end </body> </html> </notes> <label text="NGFR-ICD*"/> <bbox w="80.0" h="40.0" x="4080.0" y="275.0"/> </glyph> <glyph class="macromolecule" id="s5859_sa4243"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor-associated factor 6, E3 ubiquitin protein ligase HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:16252010 References_end </body> </html> </notes> <label text="TRAF6"/> <bbox w="80.0" h="40.0" x="4080.0" y="380.0"/> </glyph> </glyph> <glyph class="complex" id="s5961_csa434" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NADE*:NGF:NGFR:NRAGE*:NRIF* Identifiers_end References_begin: 15548667 15721744 p75NTR interactors NT-receptor interacting factor (NRIF), NT-associated cell death executor (NADE), NT-receptor-interacting MAGE homolog (NRAGE) and TNF receptor-associated factors (TRAFs) have, alone or in combination, been shown to activate JNK and promote p75NTR-dependent apoptosis 14673001 Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. References_end </body> </html> </notes> <label text="NGF:NGFR:NRAGE*:NRIF*:NADE*"/> <bbox w="107.5" h="290.0" x="3822.5" y="120.0"/> <glyph class="macromolecule" id="s5962_sa4215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor receptor HUGO:NGFR HGNC:7809 ENTREZ:4804 UNIPROT:P08138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 PMID:15721744 References_end </body> </html> </notes> <label text="NGFR"/> <bbox w="80.0" h="50.0" x="3832.5" y="175.0"/> <glyph class="unit of information" id="_ba977785-7326-4dff-b202-ff8ec211a1a1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3850.0" y="170.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5962_sa4216"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor receptor HUGO:NGFR HGNC:7809 ENTREZ:4804 UNIPROT:P08138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 PMID:15721744 References_end </body> </html> </notes> <label text="NGFR"/> <bbox w="80.0" h="50.0" x="3842.5" y="185.0"/> <glyph class="unit of information" id="_ff7b5297-2a30-40c9-9f67-2f2f7491e54f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3860.0" y="180.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5963_sa4222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor (beta polypeptide) HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 References_end </body> </html> </notes> <label text="NGF"/> <bbox w="80.0" h="40.0" x="3832.5" y="130.0"/> </glyph> <glyph class="macromolecule" id="s5963_sa4223"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor (beta polypeptide) HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 References_end </body> </html> </notes> <label text="NGF"/> <bbox w="80.0" h="40.0" x="3842.5" y="140.0"/> </glyph> <glyph class="macromolecule" id="s5831_sa4224"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor receptor (TNFRSF16) associated protein 1 HUGO:NGFRAP1 HGNC:13388 ENTREZ:27018 UNIPROT:Q00994 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:10764727 NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. References_end </body> </html> </notes> <label text="NADE*"/> <bbox w="80.0" h="40.0" x="3840.0" y="340.0"/> </glyph> <glyph class="macromolecule" id="s5832_sa4225"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: integrin beta 3 binding protein (beta3-endonexin) HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. References_end </body> </html> </notes> <label text="NRIF*"/> <bbox w="80.0" h="40.0" x="3840.0" y="290.0"/> <glyph class="state variable" id="_c0840c0b-0772-43d4-a734-52789eda5ea3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3891.5686" y="285.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5833_sa4226"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <bbox w="80.0" h="40.0" x="3842.5" y="240.0"/> </glyph> </glyph> <glyph class="complex" id="s5964_csa433" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IRS1:NGF:PI3K*:TrkA* Identifiers_end References_begin: 17604717 The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. References_end </body> </html> </notes> <label text="NGF:TrkA*:IRS1:PI3K*"/> <bbox w="110.0" h="240.0" x="3200.0" y="120.0"/> <glyph class="macromolecule" id="s5816_sa4190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:24036369 I3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), in a reaction that can be reversed by the PIP3 phosphatase PTEN PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="PI3K*"/> <bbox w="80.0" h="40.0" x="3220.0" y="290.0"/> </glyph> <glyph class="macromolecule" id="s5803_sa4197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: insulin receptor substrate 1 HUGO:IRS1 HGNC:6125 ENTREZ:3667 UNIPROT:P35568 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:24036369 PMID:22465479 Activated receptor tyrosine kinases (RTKs) activate class I phosphatidylinositol 3-kinase (PI3K) through direct binding or through tyrosine phosphorylation of scaffolding adaptors, such as IRS1, which then bind and activate PI3K References_end </body> </html> </notes> <label text="IRS1"/> <bbox w="80.0" h="40.0" x="3220.0" y="240.0"/> <glyph class="state variable" id="_1247c0b7-e0e3-427c-a629-0b09867d7e98"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3269.0686" y="235.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5965_sa4205"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor (beta polypeptide) HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 References_end </body> </html> </notes> <label text="NGF"/> <bbox w="80.0" h="40.0" x="3220.0" y="140.0"/> </glyph> <glyph class="macromolecule" id="s5965_sa4206"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor (beta polypeptide) HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 References_end </body> </html> </notes> <label text="NGF"/> <bbox w="80.0" h="40.0" x="3210.0" y="130.0"/> </glyph> <glyph class="macromolecule" id="s5966_sa4207"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:22465479 The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. References_end </body> </html> </notes> <label text="TrkA*"/> <bbox w="80.0" h="50.0" x="3220.0" y="185.0"/> <glyph class="unit of information" id="_1ea57198-0da1-4769-81f9-d21e6532e3f6"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3237.5" y="180.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5966_sa4208"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:22465479 The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. References_end </body> </html> </notes> <label text="TrkA*"/> <bbox w="80.0" h="50.0" x="3210.0" y="175.0"/> <glyph class="unit of information" id="_e5d06be7-e946-425c-875e-3b0fe10560fb"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3227.5" y="170.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5967_csa431" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PDPK1:PIP3* Identifiers_end References_begin: 17604717 AKT and PDK1 bind to PIP3 at the plasma membrane, References_end </body> </html> </notes> <label text="PIP3*:PDPK1"/> <bbox w="100.0" h="110.0" x="3470.0" y="335.0"/> <glyph class="macromolecule" id="s5801_sa4195"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: synonym:PDK1PMID:17604717 References_end </body> </html> </notes> <label text="PDPK1"/> <bbox w="80.0" h="40.0" x="3480.0" y="385.0"/> </glyph> <glyph class="simple chemical" id="s5802_sa4196"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:16618 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 References_end </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="3485.0" y="352.5"/> </glyph> </glyph> <glyph class="complex" id="s5970_csa432" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NGF:TrkA* Identifiers_end References_begin: 22465479 Binding of NGF on TrkA trigger his dimerization References_end </body> </html> </notes> <label text="NGF:TrkA*"/> <bbox w="110.0" h="130.0" x="3385.0" y="115.0"/> <glyph class="macromolecule" id="s5971_sa4199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:22465479 The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. References_end </body> </html> </notes> <label text="TrkA*"/> <bbox w="80.0" h="50.0" x="3395.0" y="170.0"/> <glyph class="unit of information" id="_d9f8f23a-1c75-4677-bfe9-93a6627ab45f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3412.5" y="165.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5971_sa4200"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:17604717 PMID:22465479 The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. References_end </body> </html> </notes> <label text="TrkA*"/> <bbox w="80.0" h="50.0" x="3405.0" y="180.0"/> <glyph class="unit of information" id="_8b2e8607-5d08-49b6-99dd-3db6253012d7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3422.5" y="175.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s5972_sa4202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor (beta polypeptide) HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 References_end </body> </html> </notes> <label text="NGF"/> <bbox w="80.0" h="40.0" x="3395.0" y="125.0"/> </glyph> <glyph class="macromolecule" id="s5972_sa4203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor (beta polypeptide) HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:22465479 References_end </body> </html> </notes> <label text="NGF"/> <bbox w="80.0" h="40.0" x="3405.0" y="135.0"/> </glyph> </glyph> <glyph class="complex" id="s5973_csa444" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:GTP binding protein* Identifiers_end References_begin: binding protein* References_end </body> </html> </notes> <label text="GDP:GTP binding protein*"/> <bbox w="150.0" h="100.0" x="3030.0" y="710.0"/> <glyph class="simple chemical" id="s5875_sa4265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:17552 KEGGCOMPOUND:C00035 Identifiers_end Maps_Modules_begin: MODULE:MITOCH_METABOLISM MODULE:DEATH-RECEPTORS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: 146-91-8 References_end </body> </html> </notes> <label text="GDP"/> <bbox w="70.0" h="25.0" x="3095.0" y="717.5"/> </glyph> <glyph class="macromolecule" id="s5968_sa4270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="GTP binding protein*"/> <bbox w="130.0" h="40.0" x="3040.0" y="750.0"/> </glyph> </glyph> <glyph class="complex" id="s5974_csa445" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:GTP binding protein* Identifiers_end References_begin: binding protein* References_end </body> </html> </notes> <label text="GTP:GTP binding protein*"/> <bbox w="150.0" h="100.0" x="3290.0" y="710.0"/> <glyph class="simple chemical" id="s5878_sa4266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end Maps_Modules_begin: MODULE:MITOCH_METABOLISM MODULE:DEATH-RECEPTORS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="GTP"/> <bbox w="70.0" h="25.0" x="3355.0" y="717.5"/> </glyph> <glyph class="macromolecule" id="s5969_sa4298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="GTP binding protein*"/> <bbox w="130.0" h="40.0" x="3305.0" y="750.0"/> </glyph> </glyph> <glyph class="complex" id="s5975_csa443" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NADE*:YWHAE Identifiers_end References_begin: 11278287 14-3-3ε binds to NADE and forms signaling complexes consisting of p75NTR, NADE, and 14-3-3 References_end </body> </html> </notes> <label text="NADE*:YWHAE"/> <bbox w="100.0" h="125.0" x="3700.0" y="585.0"/> <glyph class="macromolecule" id="s5870_sa4260"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nerve growth factor receptor (TNFRSF16) associated protein 1 HUGO:NGFRAP1 HGNC:13388 ENTREZ:27018 UNIPROT:Q00994 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:10764727 NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. References_end </body> </html> </notes> <label text="NADE*"/> <bbox w="80.0" h="40.0" x="3709.5" y="642.0"/> </glyph> <glyph class="macromolecule" id="s5869_sa4261"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: synonym:14-3-3 epsilon PMID:11278287 References_end </body> </html> </notes> <label text="YWHAE"/> <bbox w="80.0" h="40.0" x="3710.0" y="595.0"/> </glyph> </glyph> <glyph class="complex" id="s5976_csa436" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GEF*:NRAGE* Identifiers_end References_begin: 11756498 References_end </body> </html> </notes> <label text="GEF*:NRAGE*"/> <bbox w="100.0" h="120.0" x="3190.0" y="870.0"/> <glyph class="macromolecule" id="s5844_sa4235"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Rho guanine nucleotide exchange factor (GEF) 1 HUGO:ARHGEF1 HGNC:681 ENTREZ:9138 UNIPROT:Q92888 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:21893191 PMID:10985348 References_end </body> </html> </notes> <label text="GEF*"/> <bbox w="80.0" h="40.0" x="3200.0" y="920.0"/> </glyph> <glyph class="macromolecule" id="s5846_sa4236"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: melanoma antigen family D, 1 HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:12376548 NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway PMID:15721744 PMID:11546791 PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. PMID:23314527 References_end </body> </html> </notes> <label text="NRAGE*"/> <bbox w="80.0" h="40.0" x="3200.0" y="880.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s5987_sa4304" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:64585 Identifiers_end </body> </html> </notes> <label text="Sphingomyelin"/> <bbox w="105.0" h="22.5" x="5027.5" y="208.75"/> </glyph> <glyph class="simple chemical" id="s5989_sa3708" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17761 Identifiers_end References_begin: PMID:16716889 PMID:12531547 References_end </body> </html> </notes> <label text="Ceramide"/> <bbox w="70.0" h="25.0" x="5185.0" y="205.0"/> </glyph> <glyph class="complex" id="s5992_csa448" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NSMAF:SMPD1 Identifiers_end References_begin: 8663014 References_end </body> </html> </notes> <label text="NSMAF:SMPD1"/> <bbox w="100.0" h="140.0" x="4895.0" y="145.0"/> <glyph class="macromolecule" id="s4940_sa3711"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sphingomyelin phosphodiesterase 1, acid lysosomal HUGO:SMPD1 HGNC:11120 ENTREZ:6609 UNIPROT:P17405 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:16716889 Upon ligation of TNF-α, TNF-R1 recruits FAN through its N-SMase activation domain (NSD) and activates N-SMase PMID:12531547 PMID:8663014 References_end </body> </html> </notes> <label text="SMPD1"/> <bbox w="80.0" h="40.0" x="4905.0" y="215.0"/> </glyph> <glyph class="macromolecule" id="s5982_sa4301"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: neutral sphingomyelinase (N-SMase) activation associated factor HUGO:NSMAF HGNC:8017 ENTREZ:8439 UNIPROT:Q92636 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE Maps_Modules_end References_begin: PMID:12404124 PMID:11435466 PMID:16716889 PMID:28765050 References_end </body> </html> </notes> <label text="NSMAF"/> <bbox w="80.0" h="40.0" x="4905.0" y="165.0"/> <glyph class="state variable" id="_eee81035-47c6-4f0c-b6aa-74aa1b16f6d3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4923.4316" y="160.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s5993_csa446" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ceramide Identifiers_end References_begin: 12531547 The release of ceramide in small rafts correlates with the fusion of these small membrane domains to large platforms and the trapping of receptor molecules within ceramide-enriched membrane platforms 11279185 References_end </body> </html> </notes> <label text="Ceramide cluster"/> <bbox w="132.5" h="68.75" x="5322.5" y="186.25"/> <glyph class="simple chemical" id="s5994_sa4305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> N-acylsphingosine PMID: 16716889 </body> </html> </notes> <label text="Ceramide"/> <bbox w="70.0" h="25.0" x="5337.5" y="191.25"/> </glyph> <glyph class="simple chemical" id="s5994_sa4306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> N-acylsphingosine PMID: 16716889 </body> </html> </notes> <label text="Ceramide"/> <bbox w="70.0" h="25.0" x="5347.5" y="201.25"/> </glyph> <glyph class="simple chemical" id="s5994_sa4307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> N-acylsphingosine PMID: 16716889 </body> </html> </notes> <label text="Ceramide"/> <bbox w="70.0" h="25.0" x="5357.5" y="211.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s6003_sa4308" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: alkaline ceramidase 1 HUGO:ACER1 HGNC:18356 ENTREZ:125981 UNIPROT:Q8TDN7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:16716889 Nitric oxide (NO) is known to activate N-ceramidase degradation through the ubiquitine/proteasome pathway. References_end </body> </html> </notes> <label text="ACER1"/> <bbox w="80.0" h="40.0" x="2710.0" y="1680.0"/> </glyph> <glyph class="macromolecule" id="s6004_sa4309" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: alkaline ceramidase 2 HUGO:ACER2 HGNC:23675 ENTREZ:340485 UNIPROT:Q5QJU3 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:16716889 Nitric oxide (NO) is known to activate N-ceramidase degradation through the ubiquitine/proteasome pathway. References_end </body> </html> </notes> <label text="ACER2"/> <bbox w="80.0" h="40.0" x="2800.0" y="1680.0"/> </glyph> <glyph class="macromolecule" id="s6005_sa4310" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: alkaline ceramidase 3 HUGO:ACER3 HGNC:16066 ENTREZ:55331 UNIPROT:Q9NUN7 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:16716889 Nitric oxide (NO) is known to activate N-ceramidase degradation through the ubiquitine/proteasome pathway. References_end </body> </html> </notes> <label text="ACER3"/> <bbox w="80.0" h="40.0" x="2890.0" y="1680.0"/> </glyph> <glyph class="macromolecule" id="s6006_sa4311" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sphingosine kinase 1 HUGO:SPHK1 HGNC:11240 ENTREZ:8877 UNIPROT:Q9NYA1 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="SPHK1"/> <bbox w="80.0" h="40.0" x="2320.0" y="2070.0"/> </glyph> <glyph class="macromolecule" id="s6007_sa4312" compartmentRef="c1_ca1"> <notes> <html 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MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WNT1 inducible signaling pathway protein 1 HUGO:WISP1 HGNC:12769 ENTREZ:8840 UNIPROT:O95388 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: ISP1 prevents apoptotic degeneration in primary neurons during oxidant stress through the activation of protein kinase B (Akt1) References_end </body> </html> </notes> <label text="WISP1"/> <bbox w="80.0" h="40.0" x="8660.0" y="2170.0"/> </glyph> <glyph class="macromolecule" id="s6034_sa4314" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TIMP metallopeptidase inhibitor 3 HUGO:TIMP3 HGNC:11822 ENTREZ:7078 UNIPROT:P35625 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="TIMP3"/> <bbox w="80.0" h="40.0" x="3070.0" y="6900.0"/> </glyph> <glyph class="nucleic acid feature" id="s6035_sa4315" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TIMP metallopeptidase inhibitor 3 HUGO:TIMP3 HGNC:11822 ENTREZ:7078 UNIPROT:P35625 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="TIMP3"/> <bbox w="90.0" h="25.0" x="2946.5" y="7005.5"/> <glyph class="unit of information" id="_78f4fa56-ef66-458a-bfa9-71c4c6c73505"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2981.5" y="7000.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6053_sa3795" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cathepsin D HUGO:CTSD HGNC:2529 ENTREZ:1509 UNIPROT:P07339 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18955971 References_end </body> </html> </notes> <label text="CTSD"/> <bbox w="80.0" h="40.0" x="3053.0" y="2283.0"/> </glyph> <glyph class="simple chemical" id="s6054_sa3801" compartmentRef="c7_ca34"> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="2917.5" y="2147.5"/> </glyph> <glyph class="simple chemical" id="s6055_sa3804" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:57756 Identifiers_end References_begin: PMID:16716889 PMID:9443821 phingosine potentiates the transduction process of stimulus-PLA2 activation, resulting in enhancement of arachidonic acid liberation References_end </body> </html> </notes> <label text="Sphingosine"/> <bbox w="92.5" h="27.5" x="2855.0" y="2227.5"/> </glyph> <glyph class="macromolecule" id="s6106_sa4327" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: 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HGNC:12558 ENTREZ:8408 UNIPROT:O75385 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 References_end </body> </html> </notes> <label text="ULK1"/> <clone/> <bbox w="80.0" h="40.0" x="6761.0" y="6917.5"/> </glyph> <glyph class="macromolecule" id="s6107_sa4330" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-51 like autophagy activating kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 References_end 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HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:22166994 PMID:23030059 References_end </body> </html> </notes> <label text="ULK*"/> <bbox w="80.0" h="40.0" x="10392.833" y="1810.8334"/> <glyph class="state variable" id="_8ea97634-7cd7-4c1e-90e2-8ebc6324c074"> <state value="" variable="Ser 777"/> <bbox w="45.0" h="10.0" x="10446.682" y="1845.8334"/> </glyph> <glyph class="state variable" id="_ce5ed8ab-b6fa-4855-8643-5160d83b19ad"> <state value="" variable="Ser 317"/> <bbox w="45.0" h="10.0" x="10449.967" y="1805.8334"/> </glyph> <glyph class="state variable" id="_b262797b-9da6-40f6-8951-a0af8424f3b8"> <state value="P" variable="Ser 757"/> <bbox w="50.0" h="10.0" x="10371.368" y="1805.8334"/> </glyph> </glyph> <glyph class="macromolecule" id="s6116_sa4341" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:15325588 PMID:23725295 LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine PMID:24070470 References_end </body> </html> </notes> <label text="LC3*"/> <bbox w="80.0" h="40.0" x="10941.75" y="2588.5833"/> <glyph class="state variable" id="_860114ff-7efa-4dec-9fb2-1692ce5d5a12"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11016.75" y="2595.299"/> </glyph> </glyph> <glyph class="macromolecule" id="s6117_sa4342" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:15721744 PMID:22465479 References_end </body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="11020.25" y="2488.0833"/> </glyph> <glyph class="simple chemical" id="s6118_sa4344" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16618 Identifiers_end References_begin: PMID:17604717 PMID:23301705 PMID:22166994 References_end </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="10903.25" y="2503.5833"/> </glyph> <glyph class="macromolecule" id="s6119_sa4333" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="10706.25" y="2177.0833"/> <glyph class="state variable" id="_24c31a94-290c-4953-a1cf-d8a5d951d6a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10701.25" y="2183.799"/> </glyph> </glyph> <glyph class="macromolecule" id="s6120_sa4334" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RB1-inducible coiled-coil 1 HUGO:RB1CC1 HGNC:15574 ENTREZ:9821 UNIPROT:Q8TDY2 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="FIP200*"/> <bbox w="80.0" h="40.0" x="10702.25" y="2232.0833"/> </glyph> <glyph class="macromolecule" id="s6121_sa4332" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="10530.083" y="2176.5833"/> <glyph class="state variable" id="_7317ebeb-801d-45af-98da-29b170a141f8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10522.583" y="2183.299"/> </glyph> </glyph> <glyph class="complex" id="s6122_csa449" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG101*:ATG13:FIP200*:ULK* Identifiers_end References_begin: 23301705 23725295 24070470 22166994 23030059 References_end </body> </html> </notes> <label text="ULK*:FIP200*:ATG13"/> <bbox w="213.0" h="138.0" x="10876.0" y="2013.5"/> <glyph class="macromolecule" id="s6123_sa4372"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: unc-51 like autophagy activating kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:22166994 PMID:23030059 References_end </body> </html> </notes> <label text="ULK*"/> <bbox w="80.0" h="40.0" x="10990.333" y="2033.6666"/> <glyph class="state variable" id="_2239df72-22f9-43d1-afd6-97c707319014"> <state value="P" variable="Ser 777"/> <bbox w="50.0" h="10.0" x="11041.682" y="2068.6665"/> </glyph> <glyph class="state variable" id="_44f47ad8-8073-4234-bb93-ab28bd7d1b08"> <state value="P" variable="Ser 317"/> <bbox w="50.0" h="10.0" x="11044.967" y="2028.6666"/> </glyph> <glyph class="state variable" id="_a10fb39d-ee3e-4b3c-8d47-21f4912c596a"> <state value="" variable="Ser 757"/> <bbox w="45.0" h="10.0" x="10971.368" y="2028.6666"/> </glyph> </glyph> <glyph class="macromolecule" id="s6124_sa4373"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="10890.0" y="2034.3334"/> <glyph class="state variable" id="_0d46b260-48ea-4d31-b9d7-103e0938c667"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10885.0" y="2041.0491"/> </glyph> </glyph> <glyph class="macromolecule" id="s6125_sa4374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RB1-inducible coiled-coil 1 HUGO:RB1CC1 HGNC:15574 ENTREZ:9821 UNIPROT:Q8TDY2 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23301705 PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="FIP200*"/> <bbox w="80.0" h="40.0" x="10890.0" y="2083.3333"/> </glyph> <glyph class="macromolecule" id="s6370_sa4505"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: chromosome 12 open reading frame 44 HUGO:C12orf44 HGNC:25679 ENTREZ:60673 UNIPROT:Q9BSB4 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG101*"/> <bbox w="80.0" h="40.0" x="10980.75" y="2082.9167"/> </glyph> </glyph> <glyph class="phenotype" id="s6126_sa4337" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: In mammalian cells, autophagosomes emanate from the phagophore, which is assembled atthe phagophore assembly site (PAS) and can be derived from different membranes PMID:23725295 PMID:22166994 PMID:23030059 PMID:PMID:23725295 PMID:23774579 References_end </body> </html> </notes> <label text="Autophagosome initiation"/> <bbox w="185.0" h="27.0" x="10867.25" y="2396.0833"/> </glyph> <glyph class="macromolecule" id="s6128_sa4345" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 14 HUGO:ATG14 HGNC:19962 ENTREZ:22863 UNIPROT:Q6ZNE5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="ATG14"/> <bbox w="80.0" h="40.0" x="10343.25" y="2611.0833"/> </glyph> <glyph class="complex" id="s6129_csa451" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG14:BECN1:PIK3C3:PIK3R4:UVRAG Identifiers_end References_begin: 17106237 18612260 23725295 23301705 UVRAG is a plateform of interaction alowing Beclin1 and PIK3C3 interations 24070470 22166994 23030059 22093031 References_end </body> </html> </notes> <label text="BECN1:PIK3C3:ATG14"/> <bbox w="194.0" h="184.0" x="10598.25" y="2412.0833"/> <glyph class="macromolecule" id="s6206_sa4377"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23377657 PMID:17446862 PMID:27754749 References_end </body> </html> </notes> <label text="BECN1"/> <bbox w="80.0" h="40.0" x="10610.75" y="2476.3333"/> <glyph class="state variable" id="_3dd79bac-f1bb-4538-ac96-6545e2ca45e4"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10600.75" y="2471.3333"/> </glyph> <glyph class="state variable" id="_ab856f2c-68b5-423a-89c4-1beee06f96c8"> <state value="" variable="T119"/> <bbox w="30.0" h="10.0" x="10652.699" y="2471.3333"/> </glyph> </glyph> <glyph class="macromolecule" id="s6131_sa4378"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol 3-kinase, catalytic subunit type 3 HUGO:PIK3C3 HGNC:8974 ENTREZ:5289 UNIPROT:Q8NEB9 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="PIK3C3"/> <bbox w="80.0" h="40.0" x="10613.25" y="2520.3333"/> </glyph> <glyph class="macromolecule" id="s6132_sa4379"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 14 HUGO:ATG14 HGNC:19962 ENTREZ:22863 UNIPROT:Q6ZNE5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="ATG14"/> <bbox w="80.0" h="40.0" x="10702.75" y="2477.8333"/> </glyph> <glyph class="macromolecule" id="s6138_sa4380"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 4 HUGO:PIK3R4 HGNC:8982 ENTREZ:30849 UNIPROT:Q99570 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="PIK3R4"/> <bbox w="80.0" h="40.0" x="10703.25" y="2524.0833"/> </glyph> <glyph class="macromolecule" id="s6256_sa4418"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="80.0" h="40.0" x="10610.0" y="2425.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s6130_sa4364" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16038 Identifiers_end References_begin: PMID:23301705 PMID:24070470 References_end </body> </html> </notes> <label text="Phosphatidyl ethanolamine"/> <bbox w="160.0" h="33.0" x="10857.096" y="3261.3142"/> </glyph> <glyph class="macromolecule" id="s6134_sa4355" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WAS/WASL interacting protein family, member 1 HUGO:WIPF1 HGNC:12736 ENTREZ:7456 UNIPROT:O43516 WAS/WASL interacting protein family, member 2 HUGO:WIPF2 HGNC:30923 ENTREZ:147179 UNIPROT:Q8TF74 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:22166994 References_end </body> </html> </notes> <label text="WIP*"/> <bbox w="80.0" h="40.0" x="10581.25" y="2770.0833"/> </glyph> <glyph class="macromolecule" id="s6136_sa4343" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 2A HUGO:ATG2A HGNC:29028 ENTREZ:23130 UNIPROT:Q2TAZ0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:18586673 References_end </body> </html> </notes> <label text="ATG2*"/> <bbox w="80.0" h="40.0" x="10550.25" y="2636.0833"/> </glyph> <glyph class="simple chemical" id="s6139_sa4336" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22166994 References_end </body> </html> </notes> <label text="PIP2"/> <bbox w="70.0" h="25.0" x="10901.25" y="2438.5833"/> </glyph> <glyph class="macromolecule" id="s6142_sa4354" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WAS/WASL interacting protein family, member 1 HUGO:WIPF1 HGNC:12736 ENTREZ:7456 UNIPROT:O43516 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:22166994 References_end </body> </html> </notes> <label text="WIPF1"/> <bbox w="80.0" h="40.0" x="10431.25" y="2740.0833"/> </glyph> <glyph class="macromolecule" id="s6143_sa4353" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WAS/WASL interacting protein family, member 2 HUGO:WIPF2 HGNC:30923 ENTREZ:147179 UNIPROT:Q8TF74 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:22166994 References_end </body> </html> </notes> <label text="WIPF2"/> <bbox w="80.0" h="40.0" x="10430.25" y="2796.0833"/> </glyph> <glyph class="complex" id="s6146_csa453" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG2*:PIP3* Identifiers_end References_begin: PMID:23725295 PMID:18586673 References_end </body> </html> </notes> <label text="PIP3*ATG2*"/> <bbox w="99.0" h="106.0" x="10803.25" y="2602.0833"/> <glyph class="macromolecule" id="s6140_sa4383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 2A HUGO:ATG2A HGNC:29028 ENTREZ:23130 UNIPROT:Q2TAZ0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:18586673 References_end </body> </html> </notes> <label text="ATG2*"/> <bbox w="80.0" h="40.0" x="10811.75" y="2651.0833"/> </glyph> <glyph class="simple chemical" id="s6150_sa4384"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBBI:17283 </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="10815.75" y="2618.5833"/> </glyph> </glyph> <glyph class="complex" id="s6148_csa456" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PIP3*:WIP* Identifiers_end References_begin: 23725295 References_end </body> </html> </notes> <label text="PIP3*:WIP*"/> <bbox w="106.0" h="101.0" x="10792.25" y="2739.0833"/> <glyph class="macromolecule" id="s6137_sa4389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: WAS/WASL interacting protein family, member 1 HUGO:WIPF1 HGNC:12736 ENTREZ:7456 UNIPROT:O43516 WAS/WASL interacting protein family, member 2 HUGO:WIPF2 HGNC:30923 ENTREZ:147179 UNIPROT:Q8TF74 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:22166994 References_end </body> </html> </notes> <label text="WIP*"/> <bbox w="80.0" h="40.0" x="10807.75" y="2776.0833"/> </glyph> <glyph class="simple chemical" id="s6149_sa4390"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBBI:17283 </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="10812.75" y="2745.5833"/> </glyph> </glyph> <glyph class="complex" id="s6151_csa452" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LC3*:PIP3* Identifiers_end References_begin: PMID:18586673 PMID:23301705 PMID:24070470 References_end </body> </html> </notes> <label text="PIP3*:ATG18"/> <bbox w="100.0" h="120.0" x="11114.25" y="2551.0833"/> <glyph class="macromolecule" id="s6144_sa4381"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:15325588 PMID:23725295 LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine PMID:24070470 References_end </body> </html> </notes> <label text="LC3*"/> <bbox w="80.0" h="40.0" x="11123.25" y="2604.0833"/> <glyph class="state variable" id="_01920d18-052c-4106-86db-226305dd351a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11198.25" y="2610.799"/> </glyph> </glyph> <glyph class="simple chemical" id="s6152_sa4382"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBBI:17283 </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="11128.75" y="2570.5833"/> </glyph> </glyph> <glyph class="macromolecule" id="s6153_sa4362" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:15325588 PMID:23725295 LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine PMID:24070470 References_end </body> </html> </notes> <label text="LC3*"/> <bbox w="80.0" h="40.0" x="10415.75" y="2948.5833"/> <glyph class="state variable" id="_97028df5-ec52-4be1-8bda-58f073546b31"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10490.75" y="2955.299"/> </glyph> </glyph> <glyph class="macromolecule" id="s6158_sa4352" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="11316.25" y="2460.0833"/> </glyph> <glyph class="complex" id="s6161_csa455" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG12:ATG5 Identifiers_end References_begin: 23725295 PMID:24070470 PMID:22166994 References_end </body> </html> </notes> <label text="ATG5:ATG12"/> <bbox w="106.0" h="131.0" x="11100.25" y="2758.0833"/> <glyph class="macromolecule" id="s6162_sa4387"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="11110.75" y="2767.5833"/> </glyph> <glyph class="macromolecule" id="s6160_sa4388"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <bbox w="80.0" h="40.0" x="11113.75" y="2816.5833"/> </glyph> </glyph> <glyph class="macromolecule" id="s6165_sa4361" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 7 HUGO:ATG7 HGNC:16935 ENTREZ:10533 UNIPROT:O95352 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end </body> </html> </notes> <label text="ATG7"/> <bbox w="80.0" h="40.0" x="11198.25" y="3037.0833"/> </glyph> <glyph class="macromolecule" id="s6167_sa4340" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <clone/> <bbox w="80.0" h="40.0" x="11361.25" y="2581.0833"/> </glyph> <glyph class="macromolecule" id="s6167_sa4350" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <clone/> <bbox w="80.0" h="40.0" x="11218.75" y="2694.5833"/> </glyph> <glyph class="complex" id="s6170_csa454" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG10:ATG12 Identifiers_end References_begin: 23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12:ATG10"/> <bbox w="110.0" h="124.0" x="11402.25" y="2770.0833"/> <glyph class="macromolecule" id="s6169_sa4385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 10 HUGO:ATG10 HGNC:20315 ENTREZ:83734 UNIPROT:Q9H0Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:24070470 References_end </body> </html> </notes> <label text="ATG10"/> <bbox w="80.0" h="40.0" x="11419.25" y="2829.0833"/> </glyph> <glyph class="macromolecule" id="s6171_sa4386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <bbox w="80.0" h="40.0" x="11418.75" y="2780.5833"/> </glyph> </glyph> <glyph class="macromolecule" id="s6172_sa4360" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 3 HUGO:ATG3 HGNC:20962 ENTREZ:64422 UNIPROT:Q9NT62 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="ATG3"/> <bbox w="80.0" h="40.0" x="10964.75" y="3014.5833"/> </glyph> <glyph class="complex" id="s6173_csa458" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG3:LC3-I* Identifiers_end References_begin: 23301705 PMID:24070470 PMID:24257061 PMID:22166994 PMID:23725295 References_end </body> </html> </notes> <label text="ATG8*:ATG10"/> <bbox w="108.0" h="122.0" x="10847.25" y="3103.0833"/> <glyph class="macromolecule" id="s6168_sa4394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 3 HUGO:ATG3 HGNC:20962 ENTREZ:64422 UNIPROT:Q9NT62 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="ATG3"/> <bbox w="80.0" h="40.0" x="10863.25" y="3163.0833"/> </glyph> <glyph class="macromolecule" id="s6198_sa4395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="LC3-I*"/> <bbox w="80.0" h="40.0" x="10861.096" y="3111.3142"/> <glyph class="unit of information" id="_b478d8e8-c98a-4359-84f4-00af322ed5e8"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10876.096" y="3106.3142"/> </glyph> </glyph> </glyph> <glyph class="phenotype" id="s6180_sa4366" compartmentRef="c1_ca1"> <label text="Endosome fusing"/> <bbox w="134.0" h="28.0" x="11169.25" y="3309.0833"/> </glyph> <glyph class="phenotype" id="s6181_sa4368" compartmentRef="c1_ca1"> <label text="Lysosome fusing"/> <bbox w="134.0" h="32.0" x="11116.25" y="3391.0833"/> </glyph> <glyph class="phenotype" id="s6183_sa4417" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27048813 References_end </body> </html> </notes> <label text="Apoptotic death"/> <bbox w="118.0" h="29.0" x="4721.0" y="2235.5"/> </glyph> <glyph class="phenotype" id="s6184_sa4365" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 References_end </body> </html> </notes> <label text="High ATP level"/> <bbox w="109.0" h="31.0" x="11350.25" y="3297.0833"/> </glyph> <glyph class="phenotype" id="s6185_sa4367" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 References_end </body> </html> </notes> <label text="Phosphatidylserine exposure"/> <bbox w="205.0" h="29.0" x="11355.25" y="3377.0833"/> </glyph> <glyph class="macromolecule" id="s6186_sa4335" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: zinc finger, FYVE domain containing 1 HUGO:ZFYVE1 HGNC:13180 ENTREZ:53349 UNIPROT:Q9HBF4 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="DCFP1*"/> <bbox w="80.0" h="40.0" x="11068.917" y="2401.0833"/> </glyph> <glyph class="complex" id="s6187_csa450" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DCFP1*:PIP3* Identifiers_end </body> </html> </notes> <label text="DFCP1*:PIP3*"/> <bbox w="109.0" h="112.0" x="11164.25" y="2404.0833"/> <glyph class="macromolecule" id="s6188_sa4375"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: zinc finger, FYVE domain containing 1 HUGO:ZFYVE1 HGNC:13180 ENTREZ:53349 UNIPROT:Q9HBF4 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="DCFP1*"/> <bbox w="80.0" h="40.0" x="11181.25" y="2416.0833"/> </glyph> <glyph class="simple chemical" id="s6189_sa4376"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBBI:17283 </body> </html> </notes> <label text="PIP3*"/> <bbox w="70.0" h="25.0" x="11188.917" y="2462.0833"/> </glyph> </glyph> <glyph class="macromolecule" id="s6190_sa4359" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: GABA(A) receptor-associated protein like 1 HUGO:GABARAPL1 HGNC:4068 ENTREZ:23710 UNIPROT:Q9H0R8 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="GABARAPL1"/> <bbox w="80.0" h="40.0" x="10178.25" y="2959.0833"/> </glyph> <glyph class="macromolecule" id="s6192_sa4348" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="ATG8*"/> <bbox w="80.0" h="40.0" x="10179.25" y="2911.0833"/> </glyph> <glyph class="macromolecule" id="s6193_sa4358" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: GABA(A) receptor-associated protein-like 2 HUGO:GABARAPL2 HGNC:13291 ENTREZ:11345 UNIPROT:P60520 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="GATE-16*"/> <bbox w="80.0" h="40.0" x="10175.25" y="3008.0833"/> </glyph> <glyph class="macromolecule" id="s6197_sa4356" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="LC3-I*"/> <clone/> <bbox w="80.0" h="40.0" x="10752.5" y="3031.5"/> <glyph class="unit of information" id="_935d88bb-2f4d-4c76-b794-fa3effc309ed"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10767.5" y="3026.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6197_sa4444" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="LC3-I*"/> <clone/> <bbox w="80.0" h="40.0" x="11545.0" y="2727.5"/> <glyph class="unit of information" id="_b6462e8a-1d0a-499e-aebb-6ba115babbad"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11560.0" y="2722.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6204_sa4371" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy/beclin-1 regulator 1 HUGO:AMBRA1 HGNC:25990 ENTREZ:55626 UNIPROT:Q9C0C7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:21358617 References_end </body> </html> </notes> <label text="AMBRA1"/> <bbox w="80.0" h="40.0" x="9813.25" y="2451.0833"/> </glyph> <glyph class="macromolecule" id="s6205_sa4339" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23377657 PMID:17446862 PMID:27754749 References_end </body> </html> </notes> <label text="BECN1"/> <bbox w="80.0" h="40.0" x="9922.5" y="2502.5"/> <glyph class="state variable" id="_4b344313-6f85-45e0-acfe-5ee526500b0b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9912.5" y="2497.5"/> </glyph> <glyph class="state variable" id="_f7a1f059-6f12-4e1c-a772-d42fccf24c23"> <state value="" variable="T119"/> <bbox w="30.0" h="10.0" x="9964.449" y="2497.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6207_sa4338" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WAS protein family homolog 1 HUGO:WASH1 HGNC:24361 ENTREZ:100287171 UNIPROT:A8K0Z3 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="WASH1"/> <bbox w="80.0" h="40.0" x="10102.5" y="2582.5"/> </glyph> <glyph class="macromolecule" id="s6217_sa4396" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:24257061 PMID:23725295 PMID:24070470 PMID:PMID:24257061 References_end </body> </html> </notes> <label text="ATG16L1"/> <bbox w="80.0" h="40.0" x="11156.5" y="2910.5"/> </glyph> <glyph class="macromolecule" id="s6218_sa4397" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 2 (S. cerevisiae) HUGO:ATG16L2 HGNC:25464 ENTREZ:89849 UNIPROT:Q8NAA4 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG16L2"/> <bbox w="80.0" h="40.0" x="11156.5" y="2957.5"/> </glyph> <glyph class="complex" id="s6220_csa459" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG12:ATG16*:ATG5 Identifiers_end References_begin: PMID:23725295 23301705 PMID:24070470 PMID:24257061 PMID:22166994 PMID:23030059 PMID:22093031 References_end </body> </html> </notes> <label text="ATG5:ATG12"/> <bbox w="118.0" h="169.0" x="10832.0" y="2852.0"/> <glyph class="macromolecule" id="s6221_sa4399"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="10842.5" y="2862.5"/> </glyph> <glyph class="macromolecule" id="s6222_sa4400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <bbox w="80.0" h="40.0" x="10845.5" y="2911.5"/> </glyph> <glyph class="macromolecule" id="s6223_sa4401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 PMID:24257061 References_end </body> </html> </notes> <label text="ATG16*"/> <bbox w="80.0" h="40.0" x="10843.0" y="2959.0"/> </glyph> <glyph class="macromolecule" id="s6221_sa4500"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="10853.5" y="2870.25"/> </glyph> <glyph class="macromolecule" id="s6222_sa4501"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <bbox w="80.0" h="40.0" x="10856.5" y="2919.25"/> </glyph> <glyph class="macromolecule" id="s6223_sa4502"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 PMID:24257061 References_end </body> </html> </notes> <label text="ATG16*"/> <bbox w="80.0" h="40.0" x="10854.0" y="2966.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s6224_sa4402" compartmentRef="c32_ca33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:24257061 PMID:23725295 PMID:24070470 PMID:PMID:24257061 References_end </body> </html> </notes> <label text="ATG16L1"/> <bbox w="80.0" h="40.0" x="11182.0" y="2120.5"/> </glyph> <glyph class="macromolecule" id="s6225_sa4403" compartmentRef="c32_ca33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 9A HUGO:ATG9A HGNC:22408 ENTREZ:79065 UNIPROT:Q7Z3C6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:24257061 References_end </body> </html> </notes> <label text="ATG9A"/> <bbox w="80.0" h="40.0" x="11010.5" y="2204.5"/> </glyph> <glyph class="macromolecule" id="s6226_sa4404" compartmentRef="c32_ca33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 9B HUGO:ATG9B HGNC:21899 ENTREZ:285973 UNIPROT:Q674R7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="ATG9B"/> <bbox w="80.0" h="40.0" x="11013.5" y="2254.5"/> </glyph> <glyph class="macromolecule" id="s6229_sa4407" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: syntaxin 17 HUGO:STX17 HGNC:11432 ENTREZ:55014 UNIPROT:P56962 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23466629 References_end </body> </html> </notes> <label text="STX17"/> <bbox w="80.0" h="40.0" x="11549.5" y="2829.5"/> </glyph> <glyph class="macromolecule" id="s6230_sa4408" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: synaptosomal-associated protein, 29kDa HUGO:SNAP29 HGNC:11133 ENTREZ:9342 UNIPROT:O95721 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23466629 References_end </body> </html> </notes> <label text="SNAP29"/> <bbox w="80.0" h="40.0" x="11527.5" y="2880.5"/> </glyph> <glyph class="macromolecule" id="s6235_sa4406" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: vesicle-associated membrane protein 8 HUGO:VAMP8 HGNC:12647 ENTREZ:8673 UNIPROT:Q9BV40 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23466629 References_end </body> </html> </notes> <label text="VAMP8"/> <bbox w="80.0" h="40.0" x="11638.5" y="2989.5"/> </glyph> <glyph class="complex" id="s6238_csa460" compartmentRef="c7_ca34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SNAP29:STX17:VAMP8 Identifiers_end References_begin: 23578367 PMID:23466629 References_end </body> </html> </notes> <label text="STX17:SNAP29:VAMP8"/> <bbox w="194.0" h="118.0" x="11428.5" y="2974.5"/> <glyph class="macromolecule" id="s6239_sa4409"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: vesicle-associated membrane protein 8 HUGO:VAMP8 HGNC:12647 ENTREZ:8673 UNIPROT:Q9BV40 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23466629 References_end </body> </html> </notes> <label text="VAMP8"/> <bbox w="80.0" h="40.0" x="11526.75" y="2992.0"/> </glyph> <glyph class="macromolecule" id="s6241_sa4410"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: syntaxin 17 HUGO:STX17 HGNC:11432 ENTREZ:55014 UNIPROT:P56962 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23466629 References_end </body> </html> </notes> <label text="STX17"/> <bbox w="80.0" h="40.0" x="11445.75" y="2990.0"/> </glyph> <glyph class="macromolecule" id="s6240_sa4411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: synaptosomal-associated protein, 29kDa HUGO:SNAP29 HGNC:11133 ENTREZ:9342 UNIPROT:O95721 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23466629 References_end </body> </html> </notes> <label text="SNAP29"/> <bbox w="80.0" h="40.0" x="11458.75" y="3034.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6242_sa4412" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: GABA(A) receptor-associated protein like 1 HUGO:GABARAPL1 HGNC:4068 ENTREZ:23710 UNIPROT:Q9H0R8 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="GABARAPL1"/> <bbox w="70.0" h="25.0" x="5964.5" y="7265.5"/> </glyph> <glyph class="nucleic acid feature" id="s6243_sa4413" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG12"/> <clone/> <bbox w="70.0" h="25.0" x="5959.5" y="7234.5"/> </glyph> <glyph class="nucleic acid feature" id="s6243_sa4623" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG12"/> <clone/> <bbox w="70.0" h="25.0" x="7435.5" y="7260.5"/> </glyph> <glyph class="nucleic acid feature" id="s6244_sa4414" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG12"/> <clone/> <bbox w="90.0" h="25.0" x="5965.5" y="7005.5"/> <glyph class="unit of information" id="_a02fd2e0-f379-426b-8cbc-a92b5fa0dd86"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6000.5" y="7000.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6244_sa4628" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG12"/> <clone/> 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<label text="RNA"/> <bbox w="20.0" h="10.0" x="6081.5" y="7000.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6246_sa4416" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <clone/> <bbox w="80.0" h="40.0" x="10302.5" y="2322.5"/> </glyph> <glyph class="macromolecule" id="s6246_sa4630" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <clone/> <bbox w="80.0" h="40.0" x="7447.0" y="6907.0"/> </glyph> <glyph class="phenotype" id="s6259_sa4421" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23725295 PMID:23846383 PMID:27048813 References_end </body> </html> </notes> <label text="Stress"/> <bbox w="80.0" h="30.0" x="9952.5" y="2657.5"/> </glyph> <glyph class="phenotype" id="s6260_sa4422" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:27558815 PMID:27048813 PMID:27959630 Necroptosis is a form of regulated cell death that critically depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and generally manifests with morphological features of necrosis. PMID:26853145 Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. PMID:28498367 References_end </body> </html> </notes> <label text="Necrosis death"/> <bbox w="113.0" h="29.0" x="2504.0" y="2203.0"/> </glyph> <glyph class="macromolecule" id="s6261_sa4426" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SH3-domain GRB2-like endophilin B1 HUGO:SH3GLB1 HGNC:10833 ENTREZ:51100 UNIPROT:Q9Y371 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:16227588 PMID:19265852 PMID:17891140 References_end </body> </html> </notes> <label text="BIF1*"/> <bbox w="80.0" h="40.0" x="10439.125" y="2268.5"/> </glyph> <glyph class="phenotype" id="s6263_sa4425" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="Autophagosome formation"/> <bbox w="207.0" h="34.0" x="10987.5" y="2709.5"/> </glyph> <glyph class="complex" id="s6265_csa461" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BIF1*:UVRAG Identifiers_end References_begin: PMID:16227588 References_end </body> </html> </notes> <label text="UVRAG:BIF1*"/> <bbox w="100.0" h="120.0" x="10592.5" y="2279.5"/> <glyph class="macromolecule" id="s6266_sa4423"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SH3-domain GRB2-like endophilin B1 HUGO:SH3GLB1 HGNC:10833 ENTREZ:51100 UNIPROT:Q9Y371 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:16227588 PMID:19265852 PMID:17891140 References_end </body> </html> </notes> <label text="BIF1*"/> <bbox w="80.0" h="40.0" x="10603.5" y="2289.5"/> </glyph> <glyph class="macromolecule" id="s6267_sa4424"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="80.0" h="40.0" x="10602.125" y="2333.75"/> </glyph> </glyph> <glyph class="phenotype" id="s6272_sa4427" compartmentRef="c1_ca1"> <label text="Endosome formation"/> <bbox w="145.0" h="33.0" x="10996.5" y="3320.5"/> </glyph> <glyph class="phenotype" id="s6274_sa4435" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 PMID:23725295 References_end </body> </html> </notes> <label text="Nutrient starvation"/> <bbox w="135.0" h="29.0" x="10182.5" y="2779.5"/> </glyph> <glyph class="complex" id="s6275_csa462" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BIF1* Identifiers_end References_begin: PMID:16227588 References_end </body> </html> </notes> <label text="BAX*:BIF1*"/> <bbox w="100.0" h="120.0" x="10360.5" y="2115.5"/> <glyph class="macromolecule" id="s6277_sa4437"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SH3-domain GRB2-like endophilin B1 HUGO:SH3GLB1 HGNC:10833 ENTREZ:51100 UNIPROT:Q9Y371 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:16227588 PMID:19265852 PMID:17891140 References_end </body> </html> </notes> <label text="BIF1*"/> <bbox w="80.0" h="40.0" x="10373.0" y="2180.5"/> </glyph> <glyph class="macromolecule" id="s6282_sa4441"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10371.25" y="2127.5"/> <glyph class="state variable" id="_33106d4e-6fa5-4818-a257-6ddac204c122"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="10369.827" y="2122.5"/> </glyph> <glyph class="state variable" id="_07dfaac1-d8dc-4082-be06-f019ca0397b8"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="10414.834" y="2122.5"/> </glyph> <glyph class="state variable" id="_0f4a7c9f-6fd0-4a03-970b-7e64e03e9cc8"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10417.571" y="2162.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s6278_csa463" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BCL2 Identifiers_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="BAX:BCL2"/> <bbox w="100.0" h="120.0" x="10032.5" y="1962.5"/> <glyph class="macromolecule" id="s3091_sa4438"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10042.442" y="1972.0035"/> <glyph class="state variable" id="_c9737a04-8c8a-4645-bd4c-18a59a2e9c8a"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="10041.02" y="1967.0035"/> </glyph> <glyph class="state variable" id="_55c45769-a7af-4a90-8bad-8df63f44751b"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="10086.026" y="1967.0035"/> </glyph> <glyph class="state variable" id="_be6b56fa-1ba0-456b-866a-ac9a5b91339b"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10088.764" y="2007.0035"/> </glyph> </glyph> <glyph class="macromolecule" id="s3090_sa4439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="10040.442" y="2019.921"/> <glyph class="state variable" id="_37623649-fd6f-4e3f-be24-a336ad90dc8f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10058.874" y="2014.921"/> </glyph> <glyph class="state variable" id="_59a18cda-43c7-4663-b195-4fdca828bb29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10092.011" y="2014.921"/> </glyph> <glyph class="state variable" id="_4fe7e141-ac7b-40bd-8e5f-9f89353f7c09"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10035.442" y="2034.921"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s6281_sa4440" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10272.5" y="2252.5"/> <glyph class="state variable" id="_2cca483c-519a-4d08-ad82-9455e29e60d8"> <state value="?" variable="T167"/> <bbox w="35.0" h="10.0" x="10271.077" y="2247.5"/> </glyph> <glyph class="state variable" id="_94c50e25-56fc-4044-a782-6d9d5c64b95d"> <state value="?" variable="S163"/> <bbox w="35.0" h="10.0" x="10316.084" y="2247.5"/> </glyph> <glyph class="state variable" id="_66e0555a-ebe2-41e7-9faf-b8152022249a"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10318.821" y="2287.5"/> </glyph> </glyph> <glyph class="complex" id="s6283_csa464" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:RAB5* Identifiers_end References_begin: 23301705 References_end </body> </html> </notes> <label text="RAB5*:GDP"/> <bbox w="96.0" h="112.0" x="10388.5" y="3289.5"/> <glyph class="macromolecule" id="s6284_sa4428"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAB5A, member RAS oncogene family HUGO:RAB5A HGNC:9783 ENTREZ:5868 UNIPROT:P20339 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RAB5*"/> <bbox w="80.0" h="40.0" x="10394.5" y="3304.5"/> </glyph> <glyph class="simple chemical" id="s6285_sa4430"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:17552 KEGGCOMPOUND:C00035 Identifiers_end Maps_Modules_begin: MODULE:MITOCH_METABOLISM MODULE:DEATH-RECEPTORS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: 146-91-8 References_end </body> </html> </notes> <label text="GDP"/> <bbox w="70.0" h="25.0" x="10404.25" y="3354.5"/> </glyph> </glyph> <glyph class="complex" id="s6286_csa465" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:RAB5* Identifiers_end References_begin: 23301705 References_end </body> </html> </notes> <label text="RAB*:GTP"/> <bbox w="100.0" h="109.0" x="10557.5" y="3290.5"/> <glyph class="macromolecule" id="s6287_sa4429"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAB5A, member RAS oncogene family HUGO:RAB5A HGNC:9783 ENTREZ:5868 UNIPROT:P20339 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RAB5*"/> <bbox w="80.0" h="40.0" x="10569.0" y="3304.5"/> </glyph> <glyph class="simple chemical" id="s6288_sa4431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end Maps_Modules_begin: MODULE:MITOCH_METABOLISM MODULE:DEATH-RECEPTORS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="GTP"/> <bbox w="70.0" h="25.0" x="10575.25" y="3350.5"/> </glyph> </glyph> <glyph class="complex" id="s6289_csa466" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:RAB5*:UVRAG Identifiers_end References_begin: 23301705 References_end </body> </html> </notes> <label text="RAB*:GTP:UVRAG"/> <bbox w="188.0" h="106.0" x="10707.5" y="3295.5"/> <glyph class="simple chemical" id="s6290_sa4432"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1 Identifiers_end Maps_Modules_begin: MODULE:MITOCH_METABOLISM MODULE:DEATH-RECEPTORS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end </body> </html> </notes> <label text="GTP"/> <bbox w="70.0" h="25.0" x="10723.25" y="3349.5"/> </glyph> <glyph class="macromolecule" id="s6273_sa4433"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAB5A, member RAS oncogene family HUGO:RAB5A HGNC:9783 ENTREZ:5868 UNIPROT:P20339 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RAB5*"/> <bbox w="80.0" h="40.0" x="10717.0" y="3303.5"/> </glyph> <glyph class="macromolecule" id="s6291_sa4434"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="80.0" h="40.0" x="10803.0" y="3319.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6292_sa4442" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serine/threonine kinase 11 HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end References_begin: synonym:LKB1PMID:19037093 PMID:20484410 References_end </body> </html> </notes> <label text="STK11"/> <bbox w="80.0" h="40.0" x="8364.48" y="2206.4001"/> <glyph class="state variable" 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MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="7990.0" y="820.0"/> <glyph class="state variable" id="_9827755b-1104-4a4e-bae3-8b999e5be51a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8008.4316" y="815.0"/> </glyph> <glyph class="state variable" id="_3b980920-b60a-4e5e-b6ea-fddd486af573"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8041.5684" y="815.0"/> </glyph> <glyph class="state variable" id="_24334ffa-6193-403d-a001-15979b73fdab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8025.0" y="855.0"/> </glyph> </glyph> <glyph class="complex" id="s6305_csa467" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LC3-I*:SQSTM1 Identifiers_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="SQTM1:LC3-I*"/> <bbox w="137.0" h="108.0" x="11452.5" y="2587.5"/> <glyph class="macromolecule" id="s6306_sa4448"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="LC3-I*"/> <bbox w="80.0" h="40.0" x="11458.75" y="2638.5"/> <glyph class="unit of information" id="_fd726492-a072-494f-8732-5557d233059e"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11473.75" y="2633.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6307_sa4449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="11495.75" y="2596.5"/> <glyph class="state variable" id="_76bbc385-9a82-44fb-8d3e-97daac45e4ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11514.182" y="2591.5"/> </glyph> <glyph class="state variable" id="_65b8b8c2-8036-494f-a71e-7e9733ae3bfe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11547.318" y="2591.5"/> </glyph> <glyph class="state variable" id="_9ece7104-e0d9-471a-a5e6-fea1e7c2cab7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11530.75" y="2631.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s6308_csa468" compartmentRef="c28_ca28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase8,10* Identifiers_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="184.5" h="111.25" x="7235.5" y="878.75"/> <glyph class="macromolecule" id="s6309_sa3894"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7265.0" y="893.75"/> <glyph class="state variable" id="_77fcefc5-524e-4511-ac50-5363f1828bb7"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7255.0" y="900.4657"/> </glyph> </glyph> <glyph class="macromolecule" id="s6309_sa3895"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7275.0" y="903.75"/> <glyph class="state variable" id="_3c68a16a-416e-4e04-8a0b-f58e522f8a58"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7265.0" y="910.4657"/> </glyph> </glyph> <glyph class="macromolecule" id="s6309_sa3896"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7285.0" y="913.75"/> <glyph class="state variable" id="_efb70424-1e30-4339-b7a3-dd6c416eca89"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7275.0" y="920.4657"/> </glyph> </glyph> <glyph class="macromolecule" id="s6309_sa3897"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="7295.0" y="923.75"/> <glyph class="state variable" id="_d60fb7f6-bbbc-40d3-a9eb-e36af588df26"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7285.0" y="930.4657"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s6310_csa469" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase8,10*:LC3-I*:SQSTM1 Identifiers_end References_begin: 23725295 PMID:23377657 References_end </body> </html> </notes> <label text="Caspase8*:SQSTM1:LC3-I*"/> <bbox w="150.0" h="163.0" x="11441.5" y="2396.5"/> <glyph class="macromolecule" id="s6311_sa4451"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="11489.625" y="2455.5"/> <glyph class="state variable" id="_21b9a704-3ca0-46b3-ab54-f966fd744d6d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11508.057" y="2450.5"/> </glyph> <glyph class="state variable" id="_652de2b6-d26c-47d7-8f95-651df053d7f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11541.193" y="2450.5"/> </glyph> <glyph class="state variable" id="_a211420e-44e6-4c72-a92e-f4d678b935ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11524.625" y="2490.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6312_sa4452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="LC3-I*"/> <bbox w="80.0" h="40.0" x="11452.625" y="2497.5"/> <glyph class="unit of information" id="_5b06a2f1-d369-47f9-b1c1-dad2f0936a21"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11467.625" y="2492.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6313_sa4453"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="11466.875" y="2410.5"/> <glyph class="state variable" id="_3c066719-f867-4574-aeed-b5db4418ce2b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11456.875" y="2417.2158"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s6318_csa470" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG5:Caspase8,10*:FADD Identifiers_end References_begin: PMID:23787782 PMID:22362782 References_end </body> </html> </notes> <label text="Caspase8,10*:ATG5:FADD"/> <bbox w="133.0" h="162.0" x="11247.5" y="2233.5"/> <glyph class="macromolecule" id="s6316_sa4457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="11278.929" y="2338.5"/> </glyph> <glyph class="macromolecule" id="s6317_sa4459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="11276.929" y="2292.2144"/> </glyph> <glyph class="macromolecule" id="s6319_sa4461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <bbox w="110.0" h="40.0" x="11259.929" y="2246.2144"/> <glyph class="state variable" id="_b4a88f86-7f17-409a-a25c-6fcba45a7fa4"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11249.929" y="2252.9302"/> </glyph> </glyph> </glyph> <glyph class="phenotype" id="s6320_sa4462" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23774579 Autophagy is induced in cells after many stressful situations such as starvation, hypoxia and infection, among others. Its finely tuned regulation is essential to maintain cell and tissue homeostasis PMID:19037093 PMID:23846383 PMID:20724831 PMID:27754749 PMID:27048813 References_end </body> </html> </notes> <label text="Autophagy survival"/> <bbox w="163.0" h="29.0" x="10676.5" y="3519.5"/> </glyph> <glyph class="phenotype" id="s6321_sa4370" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 PMID:23774579 PMID:27754749 PMID:27048813 References_end </body> </html> </notes> <label text="Autophagy death"/> <bbox w="124.0" h="34.0" x="11139.25" y="3454.0833"/> </glyph> <glyph class="complex" id="s6322_csa471" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2-XL* Identifiers_end References_begin: PMID:17446862 PMID:23377657 References_end </body> </html> </notes> <label text="BAD:BCL2-XL*"/> <bbox w="100.0" h="124.0" x="10032.5" y="1820.5"/> <glyph class="macromolecule" id="s6323_sa4463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="10041.589" y="1836.2142"/> <glyph class="state variable" id="_2808fdbb-8c13-4126-ae18-89f109db8911"> <state value="active" variable=""/> <bbox w="40.0" h="10.0" x="10061.589" y="1831.2142"/> </glyph> <glyph class="state variable" id="_46a5fecb-807e-4a62-8f56-3b83d4f2910f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10060.184" y="1831.2142"/> </glyph> <glyph class="state variable" id="_c4a5992f-8eca-42f4-a282-855dd9db0d71"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="10083.538" y="1831.2142"/> </glyph> </glyph> <glyph class="macromolecule" id="s6324_sa4464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="10038.214" y="1884.2142"/> </glyph> </glyph> <glyph class="macromolecule" id="s6325_sa4467" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="9702.5" y="2402.5"/> <glyph class="state variable" id="_3be8c1f2-dc3f-4822-a0bf-aad3b34f2d0d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9720.932" y="2397.5"/> </glyph> <glyph class="state variable" id="_e8d47992-0241-48eb-bccb-a99e43e922ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9754.068" y="2397.5"/> </glyph> <glyph class="state variable" id="_fbd1facf-5d58-449f-b5b2-09510f1470d3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9695.0" y="2417.5"/> </glyph> </glyph> <glyph class="complex" id="s6326_csa472" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMBRA1:BCL2 Identifiers_end References_begin: 23377657 21358617 References_end </body> </html> </notes> <label text="AMBRA1:BCL2"/> <bbox w="100.0" h="120.0" x="9480.0" y="1890.0"/> <glyph class="macromolecule" id="s6330_sa4468"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy/beclin-1 regulator 1 HUGO:AMBRA1 HGNC:25990 ENTREZ:55626 UNIPROT:Q9C0C7 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:21358617 References_end </body> </html> </notes> <label text="AMBRA1"/> <bbox w="80.0" h="40.0" x="9485.286" y="1903.7142"/> </glyph> <glyph class="macromolecule" id="s6331_sa4469"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="9486.286" y="1955.7142"/> <glyph class="state variable" id="_c969443c-728c-41cb-86f6-908a59caba85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9504.718" y="1950.7142"/> </glyph> <glyph class="state variable" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CASP8 and FADD-like apoptosis regulator HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:15760909 PMID:19838173 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce References_end </body> </html> </notes> <label text="CFLAR"/> <bbox w="80.0" h="40.0" x="11564.214" y="3275.3572"/> <glyph class="state variable" id="_da5f2777-add2-4d11-a81d-db5ebb0c9edc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11615.782" y="3270.3572"/> </glyph> </glyph> <glyph class="macromolecule" id="s6334_sa4474"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 3 HUGO:ATG3 HGNC:20962 ENTREZ:64422 UNIPROT:Q9NT62 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="ATG3"/> <bbox w="80.0" h="40.0" x="11565.214" y="3319.2144"/> </glyph> </glyph> <glyph class="macromolecule" id="s6339_sa4477" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 3 HUGO:ATG3 HGNC:20962 ENTREZ:64422 UNIPROT:Q9NT62 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="cleaved ATG3*"/> <bbox w="80.0" h="40.0" x="10959.5" y="2890.5"/> <glyph class="unit of information" id="_51f0056c-9782-4926-8703-51dc3c9b2a6f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10974.5" y="2885.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6340_sa4478" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 4D, cysteine peptidase HUGO:ATG4D HGNC:20789 ENTREZ:84971 UNIPROT:Q86TL0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="Cleaved ATG4D*"/> <bbox w="80.0" h="40.0" x="10371.5" y="2861.5"/> <glyph class="unit of information" id="_bc94c330-a951-4ea7-84b4-3f495720c0dd"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10386.5" y="2856.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6341_sa4479" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23377657 References_end </body> </html> </notes> <label text="Cleaved AMBRA1"/> <bbox w="80.0" h="40.0" x="9812.5" y="2572.5"/> <glyph class="unit of information" id="_f9218f83-ad76-430c-a326-1b25737774cd"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9827.5" y="2567.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6342_sa4480" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:22427918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:20531300 PMID:23301705 PMID:28574505 References_end </body> </html> </notes> <label text="cleaved~Caspase8*"/> <bbox w="80.0" h="40.0" x="10978.071" y="2792.3572"/> <glyph class="unit of information" id="_71713ec4-2e8b-4e38-a11b-21ab9cd99fae"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10993.071" y="2787.3572"/> </glyph> </glyph> <glyph class="source and sink" id="s6343_sa4481" compartmentRef="c7_ca34"> <label text="s6343"/> <bbox w="30.0" h="30.0" x="11634.5" y="3066.5"/> </glyph> <glyph class="macromolecule" id="s6348_sa4482" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:22581845 References_end </body> </html> </notes> <label text="cleaved BAX*"/> <bbox w="80.0" h="40.0" x="4530.0" y="5730.0"/> <glyph class="unit of information" id="_5a779166-4b31-46ac-ba66-8c23d66efe3f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="4545.0" y="5725.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s6353_sa4483" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <clone/> <bbox w="80.0" h="40.0" x="11600.0" y="2250.0"/> </glyph> <glyph class="macromolecule" id="s6353_sa4691" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <clone/> <bbox w="80.0" h="40.0" x="7016.0" y="6920.0"/> </glyph> <glyph class="macromolecule" id="s6354_sa4484" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Cleaved ATG5*"/> <bbox w="80.0" h="40.0" x="11599.5" y="2152.5"/> <glyph class="unit of information" id="_0fe2cf74-0bb9-49ed-b674-80a61617b0b8"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11614.5" y="2147.5"/> </glyph> </glyph> <glyph class="complex" id="s6355_csa475" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:Cleaved ATG5* Identifiers_end </body> </html> </notes> <label text="BCL2-XL:Cleaved ATG5*"/> <bbox w="100.0" h="120.0" x="11625.5" y="2002.5"/> <glyph class="macromolecule" id="s6356_sa4486"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="11637.5" y="2008.5"/> </glyph> <glyph class="macromolecule" id="s6357_sa4487"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="Cleaved ATG5*"/> <bbox w="80.0" h="40.0" x="11639.0" y="2055.5"/> <glyph class="unit of information" id="_88c596e8-e758-4b77-9629-9cea00cdcbc6"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11654.0" y="2050.5"/> </glyph> </glyph> </glyph> <glyph class="phenotype" id="s6358_sa4488" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23725295 PMID:12546687 References_end </body> </html> </notes> <label text="Low AMP/ATP ratio"/> <bbox w="132.0" h="31.0" x="8100.0" y="2647.0"/> </glyph> <glyph class="phenotype" id="s6359_sa4489" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12546687 PMID:23110147 Any energy inbalance increases the AMP/ATP ratio and activates AMPK through LKB1 activation PMID:23725295 References_end </body> </html> </notes> <label text="High AMP/ATP ratio"/> <bbox w="134.0" h="30.0" x="8348.0" y="2650.0"/> </glyph> <glyph class="phenotype" id="s6360_sa4490" compartmentRef="c1_ca1"> <label text="Protein and lipids degradation"/> <bbox w="207.0" h="26.0" x="10466.5" y="3607.0"/> </glyph> <glyph class="phenotype" id="s6361_sa4491" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 References_end </body> </html> </notes> <label text="Energy production"/> <bbox w="140.0" h="29.0" x="10753.5" y="3597.5"/> </glyph> <glyph class="phenotype" id="s6362_sa4492" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 References_end </body> </html> </notes> <label text="Decreased Amino acid availability"/> <bbox w="253.0" h="30.0" x="10686.0" y="1857.5"/> </glyph> <glyph class="phenotype" id="s6363_sa4499" compartmentRef="c1_ca1"> <label text="Mitochondrial elongation"/> <bbox w="171.0" h="27.0" x="10008.561" y="3404.25"/> </glyph> <glyph class="macromolecule" id="s6368_sa4503" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: KIAA0226 HUGO:KIAA0226 HGNC:28991 ENTREZ:9711 UNIPROT:Q92622 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="KIAA0226"/> <bbox w="80.0" h="40.0" x="10457.5" y="2555.5"/> </glyph> <glyph class="macromolecule" id="s6369_sa4504" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: chromosome 12 open reading frame 44 HUGO:C12orf44 HGNC:25679 ENTREZ:60673 UNIPROT:Q9BSB4 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG101*"/> <bbox w="80.0" h="40.0" x="10700.0" y="1990.0"/> </glyph> <glyph class="macromolecule" id="s6371_sa4506" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:15325588 PMID:23725295 LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine PMID:24070470 References_end </body> </html> </notes> <label text="LC3*"/> <bbox w="80.0" h="40.0" x="10501.0" y="3034.5"/> <glyph class="state variable" id="_e40ef1ba-ef9f-4a82-b9cd-a1114f03b148"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10573.5" y="3041.2158"/> </glyph> </glyph> <glyph class="simple chemical" id="s6372_sa4507" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17489 Identifiers_end </body> </html> </notes> <label text="cAMP"/> <bbox w="70.0" h="25.0" x="9711.088" y="3648.5134"/> </glyph> <glyph class="phenotype" id="s6373_sa4508" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Lipid synthesis"/> <bbox w="80.0" h="30.0" x="780.24347" y="3170.125"/> </glyph> <glyph class="phenotype" id="s6374_sa4509" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19942859 Lipolityc signal induce PKA activation that leads to AMPK activation and so lipid resynthesis References_end </body> </html> </notes> <label text="Lipolytic signal"/> <bbox w="104.0" h="28.0" x="10554.5" y="3447.5"/> </glyph> <glyph class="phenotype" id="s6379_sa4510" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23725295 PMID:17135238 References_end </body> </html> </notes> <label text="Unfolded Protein Response"/> <bbox w="189.0" h="32.0" x="11414.5" y="3524.5"/> </glyph> <glyph class="phenotype" id="s6380_sa4511" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22025673 PMID:12777372 References_end </body> </html> </notes> <label text="Hypoxia"/> <bbox w="80.0" h="30.0" x="9725.0" y="2680.0"/> </glyph> <glyph class="macromolecule" id="s6381_sa4512" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PTEN induced putative kinase 1 HUGO:PINK1 HGNC:14581 ENTREZ:65018 UNIPROT:Q9BXM7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PINK1"/> <bbox w="80.0" h="40.0" x="3610.0" y="6080.0"/> </glyph> <glyph class="macromolecule" id="s6382_sa4513" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PTEN induced putative kinase 1 HUGO:PINK1 HGNC:14581 ENTREZ:65018 UNIPROT:Q9BXM7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PINK1"/> <bbox w="80.0" h="40.0" x="3610.0" y="6190.0"/> </glyph> <glyph class="macromolecule" id="s6383_sa4514" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: parkin RBR E3 ubiquitin protein ligase HUGO:PARK2 HGNC:8607 ENTREZ:5071 UNIPROT:O60260 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PARK2"/> <bbox w="80.0" h="40.0" x="3530.0" y="6340.0"/> </glyph> <glyph class="phenotype" id="s6385_sa4517" compartmentRef="c1_ca1"> <label text="Mitochondrial Membrane ubiquitinylation"/> <bbox w="297.0" h="22.0" x="9167.527" y="3552.7634"/> </glyph> <glyph class="phenotype" id="s6386_sa4518" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21179058 PMID:27754749 PMID:23946931 References_end </body> </html> </notes> <label text="Mitophagy"/> <bbox w="80.0" h="30.0" x="9275.0" y="3620.0"/> </glyph> <glyph class="phenotype" id="s6388_sa4519" compartmentRef="c5_ca5"> <label text="Mitochondrial damage"/> <bbox w="80.0" h="30.0" x="3520.0" y="5925.0"/> </glyph> <glyph class="complex" id="s6389_csa476" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARK2:PINK1 Identifiers_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="PINK1:PARK2"/> <bbox w="102.0" h="120.0" x="3660.25" y="6408.0"/> <glyph class="macromolecule" id="s6390_sa4515"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: parkin RBR E3 ubiquitin protein ligase HUGO:PARK2 HGNC:8607 ENTREZ:5071 UNIPROT:O60260 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PARK2"/> <bbox w="80.0" h="40.0" x="3670.4265" y="6414.8237"/> </glyph> <glyph class="macromolecule" id="s6387_sa4516"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: PTEN induced putative kinase 1 HUGO:PINK1 HGNC:14581 ENTREZ:65018 UNIPROT:Q9BXM7 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="PINK1"/> <bbox w="80.0" h="40.0" x="3669.7793" y="6462.4707"/> </glyph> </glyph> <glyph class="macromolecule" id="s6391_sa4520" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2/adenovirus E1B 19kDa interacting protein 3-like HUGO:BNIP3L HGNC:1085 ENTREZ:665 UNIPROT:O60238 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="BNIP3L"/> <bbox w="80.0" h="40.0" x="3830.25" y="6336.0"/> </glyph> <glyph class="phenotype" id="s6392_sa4521" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23846383 References_end </body> </html> </notes> <label text="Inability to produce ATP"/> <bbox w="80.0" h="30.0" x="3671.25" y="5927.0"/> </glyph> <glyph class="phenotype" id="s6393_sa4523" compartmentRef="c1_ca1"> <label text="Adequation in ATP comsumption/production"/> <bbox w="300.0" h="29.0" x="11037.5" y="3663.0"/> </glyph> <glyph class="phenotype" id="s6394_sa4522" compartmentRef="c1_ca1"> <label text="Inadequation in ATP comsumption/production"/> <bbox w="300.0" h="29.0" x="11036.5" y="3574.5"/> </glyph> <glyph class="simple chemical" id="s6399_sa4524" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: poly(ADP-ribose) polymer PMID:17116881 PMID:24684389 References_end </body> </html> </notes> <label text="PAR"/> <bbox w="70.0" h="25.0" x="1855.0" y="7927.5"/> </glyph> <glyph class="simple chemical" id="s6400_sa4525" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="NAD+"/> <bbox w="70.0" h="25.0" x="1689.5" y="7922.5"/> </glyph> <glyph class="macromolecule" id="s6401_sa4526" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nudix (nucleoside diphosphate linked moiety X)-type motif 5 HUGO:NUDT5 HGNC:8052 ENTREZ:11164 UNIPROT:Q9UKK9 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23110147 References_end </body> </html> </notes> <label text="NUDT5"/> <bbox w="80.0" h="40.0" x="1411.5" y="7926.0"/> </glyph> <glyph class="macromolecule" id="s6402_sa4527" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nudix (nucleoside diphosphate linked moiety X)-type motif 9 HUGO:NUDT9 HGNC:8056 ENTREZ:53343 UNIPROT:Q9BW91 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23110147 References_end </body> </html> </notes> <label text="NUDT9"/> <bbox w="80.0" h="40.0" x="1537.5" y="7842.0"/> </glyph> <glyph class="macromolecule" id="s6403_sa4528" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nudix (nucleoside diphosphate linked moiety X)-type motif 9 HUGO:NUDT9 HGNC:8056 ENTREZ:53343 UNIPROT:Q9BW91 nudix (nucleoside diphosphate linked moiety X)-type motif 5 HUGO:NUDT5 HGNC:8052 ENTREZ:11164 UNIPROT:Q9UKK9 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23110147 References_end </body> </html> </notes> <label text="NUDIX*"/> <bbox w="80.0" h="40.0" x="1538.5" y="7929.0"/> </glyph> <glyph class="simple chemical" id="s6404_sa4529" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: ChEBI:16960 References_end </body> </html> </notes> <label text="ADP-ribose"/> <bbox w="70.0" h="25.0" x="1856.5" y="8000.5"/> </glyph> <glyph class="simple chemical" id="s6405_sa4530" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="AMP"/> <bbox w="70.0" h="25.0" x="1696.5" y="8004.5"/> </glyph> <glyph class="phenotype" id="s6410_sa4531" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:23110147 References_end </body> </html> </notes> <label text="High AMP level"/> <bbox w="108.0" h="29.0" x="1537.5" y="8002.0"/> </glyph> <glyph class="macromolecule" id="s6411_sa4532" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1 HGNC:270 ENTREZ:142 UNIPROT:P09874 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:17116881 PMID:24684389 PARP-1 becomes overactivated and produces toxic levels of PAR, which translocates to the cytosol, from where it signals to AIF to effect its nuclear translocation PMID:24976506 References_end </body> </html> </notes> <label text="PARP1"/> <clone/> <bbox w="80.0" h="40.0" x="1765.5" y="7816.0"/> </glyph> <glyph class="macromolecule" id="s6411_sa4534" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1 HGNC:270 ENTREZ:142 UNIPROT:P09874 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:17116881 PMID:24684389 PARP-1 becomes overactivated and produces toxic levels of PAR, which translocates to the cytosol, from where it signals to AIF to effect its nuclear translocation PMID:24976506 References_end </body> </html> </notes> <label text="PARP1"/> <clone/> <bbox w="80.0" h="40.0" x="1630.0" y="7820.0"/> </glyph> <glyph class="macromolecule" id="s6412_sa4533" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) glycohydrolase HUGO:PARG HGNC:8605 ENTREZ:8505 UNIPROT:Q86W56 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:23110147 PMID:24684389 References_end </body> </html> </notes> <label text="PARG"/> <bbox w="80.0" h="40.0" x="1970.5" y="7956.0"/> </glyph> <glyph class="phenotype" id="s6413_sa4535" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:23110147 References_end </body> </html> </notes> <label text="NAD and ATP depletion"/> <bbox w="155.0" h="31.0" x="1592.5" y="7554.5"/> </glyph> <glyph class="simple chemical" id="s6418_sa4536" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="H20"/> <clone/> <bbox w="70.0" h="25.0" x="1845.0" y="8047.5"/> </glyph> <glyph class="simple chemical" id="s6418_sa4538" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="H20"/> <clone/> <bbox w="70.0" h="25.0" x="1628.0" y="7880.0"/> </glyph> <glyph class="simple chemical" id="s6419_sa4537" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: ChEBI:16300 References_end </body> </html> </notes> <label text="Ribose-1-P"/> <bbox w="94.0" h="24.0" x="1622.5" y="8042.5"/> </glyph> <glyph class="simple chemical" id="s6420_sa4539" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: ChEBI:17154 References_end </body> </html> </notes> <label text="Nicotinamide"/> <bbox w="96.0" h="26.0" x="1862.0" y="7847.0"/> </glyph> <glyph class="simple chemical" id="s6424_sa4540" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: poly(ADP-ribose) polymer PMID:17116881 References_end </body> </html> </notes> <label text="PAR"/> <bbox w="70.0" h="25.0" x="1935.0" y="6904.37"/> </glyph> <glyph class="nucleic acid feature" id="s6429_sa4541" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 1-1 HUGO:MIR1-1 HGNC:31499 ENTREZ:406904 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR1-1"/> <bbox w="90.0" h="25.0" x="2436.0" y="6631.5"/> <glyph class="unit of information" id="_5854a82b-1ede-4c84-b55c-52b7dce42015"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2466.0" y="6626.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6430_sa4542" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 1-2 HUGO:MIR1-2 HGNC:31500 ENTREZ:406905 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR1-2"/> <bbox w="90.0" h="25.0" x="2360.0" y="6633.5"/> <glyph class="unit of information" id="_ae2f4d10-35c2-4270-abb7-7ad0600b5f3d"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2390.0" y="6628.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6431_sa4543" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 1-1 HUGO:MIR1-1 HGNC:31499 ENTREZ:406904 microRNA 1-2 HUGO:MIR1-2 HGNC:31500 ENTREZ:406905 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR1*"/> <bbox w="90.0" h="25.0" x="2405.0" y="6674.5"/> <glyph class="unit of information" id="_cb4b517a-af41-4a23-8154-e56eb88d237c"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2435.0" y="6669.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6432_sa4544" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP70*"/> <bbox w="70.0" h="25.0" x="2911.5" y="7347.5"/> </glyph> <glyph class="nucleic acid feature" id="s6433_sa4545" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP70*"/> <bbox w="90.0" h="25.0" x="2779.5" y="7044.5"/> <glyph class="unit of information" id="_1ceaf2f8-2a8e-4773-8b82-398ad8d4240a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2814.5" y="7039.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6434_sa4546" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 60kDa protein 1 (chaperonin) HUGO:HSPD1 HGNC:5261 ENTREZ:3329 UNIPROT:P10809 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP60*"/> <bbox w="70.0" h="25.0" x="2912.5" y="7379.5"/> </glyph> <glyph class="nucleic acid feature" id="s6435_sa4547" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 60kDa protein 1 (chaperonin) HUGO:HSPD1 HGNC:5261 ENTREZ:3329 UNIPROT:P10809 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP60*"/> <bbox w="90.0" h="25.0" x="2745.5" y="7114.5"/> <glyph class="unit of information" id="_8705dcfe-5c88-4103-bdfd-cb8472ddc9b7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2780.5" y="7109.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6436_sa4548" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 133a-1 HUGO:MIR133A1 HGNC:31517 ENTREZ:406922 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR133A1"/> <bbox w="90.0" h="25.0" x="5729.0" y="6629.5"/> <glyph class="unit of information" id="_a1c32295-79b4-41ad-887f-9d78e778cd9a"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5759.0" y="6624.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6437_sa4549" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 133a-2 HUGO:MIR133A2 HGNC:31518 ENTREZ:406923 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR133A2"/> <bbox w="90.0" h="25.0" x="5816.0" y="6624.5"/> <glyph class="unit of information" id="_07710e6e-3487-494a-83fe-7bf53265a8eb"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5846.0" y="6619.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6438_sa4550" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end </body> </html> </notes> <label text="FASL"/> <bbox w="70.0" h="25.0" x="3002.5" y="7272.5"/> </glyph> <glyph class="nucleic acid feature" id="s6439_sa4551" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end </body> </html> </notes> <label text="FASL"/> <bbox w="90.0" h="25.0" x="2944.5" y="7049.5"/> <glyph class="unit of information" id="_35e184d5-b0af-4c14-978a-13de956edc41"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2979.5" y="7044.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6440_sa4552" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 29a HUGO:MIR29A HGNC:31616 ENTREZ:407021 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR29A"/> <bbox w="90.0" h="25.0" x="1783.0" y="6672.5"/> <glyph class="unit of information" id="_e3b80e45-7cef-47c1-b31d-98e0a0c3cebb"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1813.0" y="6667.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6441_sa4553" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR29B2"/> <bbox w="90.0" h="25.0" x="1790.0" y="6709.5"/> <glyph class="unit of information" id="_2194305a-9156-4433-ba01-7ca20b8d69aa"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1820.0" y="6704.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6442_sa4554" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 29c HUGO:MIR29C HGNC:31621 ENTREZ:407026 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR29C"/> <bbox w="90.0" h="25.0" x="1791.0" y="6737.5"/> <glyph class="unit of information" id="_60f87947-6214-4771-a516-851dfea42d67"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1821.0" y="6732.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6443_sa4555" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 29a HUGO:MIR29A HGNC:31616 ENTREZ:407021 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 microRNA 29c HUGO:MIR29C HGNC:31621 ENTREZ:407026 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR29*"/> <bbox w="90.0" h="25.0" x="1903.0" y="6673.5"/> <glyph class="unit of information" id="_a28b6e66-f788-476a-9c0c-0fe3f03e144e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1933.0" y="6668.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6444_sa4556" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cell division cycle 42 HUGO:CDC42 HGNC:1736 ENTREZ:998 UNIPROT:P60953 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDC42"/> <bbox w="70.0" h="25.0" x="2095.5" y="7280.5"/> </glyph> <glyph class="nucleic acid feature" id="s6445_sa4557" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cell division cycle 42 HUGO:CDC42 HGNC:1736 ENTREZ:998 UNIPROT:P60953 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDC42"/> <bbox w="90.0" h="25.0" x="2108.5" y="7017.5"/> <glyph class="unit of information" id="_f3b66292-f357-4850-8177-cb6625664bc7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2143.5" y="7012.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6446_sa4558" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR34B"/> <bbox w="90.0" h="25.0" x="2289.0" y="6635.5"/> <glyph class="unit of information" id="_fe3e8739-2baa-4904-a2f4-395734381874"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2319.0" y="6630.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6447_sa4559" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR34*"/> <bbox w="90.0" h="25.0" x="2314.0" y="6672.5"/> <glyph class="unit of information" id="_6984d62f-3d1d-4892-9fe4-e0650dd8f7b9"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2344.0" y="6667.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6448_sa4560" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN1A"/> <bbox w="70.0" h="25.0" x="2494.5" y="7292.5"/> </glyph> <glyph class="nucleic acid feature" id="s6449_sa4561" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN1A"/> <bbox w="90.0" h="25.0" x="2469.5" y="7015.5"/> <glyph class="unit of information" id="_791bfc70-a232-4f37-9693-58a0d9949f91"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2504.5" y="7010.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6450_sa4562" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 9A HUGO:ATG9A HGNC:22408 ENTREZ:79065 UNIPROT:Q7Z3C6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG9A"/> <bbox w="70.0" h="25.0" x="2417.5" y="7288.5"/> </glyph> <glyph class="nucleic acid feature" id="s6451_sa4563" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 9A HUGO:ATG9A HGNC:22408 ENTREZ:79065 UNIPROT:Q7Z3C6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG9A"/> <bbox w="90.0" h="25.0" x="2399.5" y="7011.5"/> <glyph class="unit of information" id="_7ff2550e-5f0e-49ec-8712-30d4750fc404"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2434.5" y="7006.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6452_sa4564" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 16-2 HUGO:MIR16-2 HGNC:31546 ENTREZ:406951 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR16-2"/> <bbox w="90.0" h="25.0" x="2602.0" y="6631.5"/> <glyph class="unit of information" id="_c65edf4b-f93a-42f0-9104-0f9950141e5d"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2632.0" y="6626.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6453_sa4565" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 16-2 HUGO:MIR16-2 HGNC:31546 ENTREZ:406951 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR16*"/> <bbox w="90.0" h="25.0" x="2556.0" y="6674.5"/> <glyph class="unit of information" id="_01d01d91-b54b-47c0-bc08-f55cf26e2391"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2586.0" y="6669.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6454_sa4566" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 192 HUGO:MIR192 HGNC:31562 ENTREZ:406967 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR192"/> <bbox w="90.0" h="25.0" x="2060.0" y="6735.5"/> <glyph class="unit of information" id="_2430acc1-6b67-49ce-8b0e-73405564e762"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2090.0" y="6730.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6455_sa4567" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 215 HUGO:MIR215 HGNC:31592 ENTREZ:406997 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR215"/> <bbox w="90.0" h="25.0" x="2131.0" y="6731.5"/> <glyph class="unit of information" id="_460fcef8-c91f-4320-b49f-825277aa4959"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2161.0" y="6726.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6457_sa4570" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 382 HUGO:MIR382 HGNC:31875 ENTREZ:494331 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR382"/> <bbox w="90.0" h="25.0" x="4865.0" y="6680.5"/> <glyph class="unit of information" id="_47697b06-3d32-47e8-a3c2-44868d542a71"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4895.0" y="6675.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6458_sa4571" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 369 HUGO:MIR369 HGNC:31783 ENTREZ:442914 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR369"/> <bbox w="90.0" h="25.0" x="4782.0" y="6686.5"/> <glyph class="unit of information" id="_5f4abea8-6baf-4e02-a5d1-76358edc01ce"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4812.0" y="6681.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6459_sa4572" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 544a HUGO:MIR544A HGNC:32530 ENTREZ:664613 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR544"/> <bbox w="90.0" h="25.0" x="4961.0" y="6679.5"/> <glyph class="unit of information" id="_48d8e8b7-bdf2-496d-aea7-7439a0915c86"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4991.0" y="6674.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6460_sa4573" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 134 HUGO:MIR134 HGNC:31519 ENTREZ:406924 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR134"/> <bbox w="90.0" h="25.0" x="5056.0" y="6677.5"/> <glyph class="unit of information" id="_6900ea0a-6245-4591-af5f-91974650379b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5086.0" y="6672.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6461_sa4574" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FAS"/> <bbox w="70.0" h="25.0" x="3333.5" y="7257.5"/> </glyph> <glyph class="nucleic acid feature" id="s6462_sa4575" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FAS"/> <bbox w="90.0" h="25.0" x="3312.5" y="7114.5"/> <glyph class="unit of information" id="_daf9fb7e-6ae6-408c-86d2-55ac0c639fb7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3347.5" y="7109.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6463_sa4576" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="40.0" x="3252.0" y="6896.87"/> <glyph class="state variable" id="_78cdf907-1ffe-4628-8b3f-4bc23622bca6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3327.0" y="6903.586"/> </glyph> <glyph class="unit of information" id="_7f504d96-1a07-4977-9659-f5b0c5da87f7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3269.5" y="6891.87"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6464_sa4577" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 143 HUGO:MIR143 HGNC:31530 ENTREZ:406935 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR143"/> <bbox w="90.0" h="25.0" x="2786.0" y="6653.5"/> <glyph class="unit of information" id="_03675a95-e32b-4d99-af71-13c339dc46d6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2816.0" y="6648.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6465_sa4578" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:26775703 HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. References_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="70.0" h="25.0" x="3171.5" y="7263.5"/> </glyph> <glyph class="nucleic acid feature" id="s6465_sa4758" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:26775703 HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. References_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="70.0" h="25.0" x="9347.266" y="7172.5"/> </glyph> <glyph class="nucleic acid feature" id="s6467_sa4580" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="90.0" h="25.0" x="3238.5" y="7043.5"/> <glyph class="unit of information" id="_545fe1a3-5455-4a75-9993-e6ef13faffdd"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3273.5" y="7038.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6467_sa4757" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="90.0" h="25.0" x="9337.266" y="7083.5"/> <glyph class="unit of information" id="_11d834ba-9935-4c3b-869e-23c0209db58d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9372.266" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6468_sa4582" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 223 HUGO:MIR223 HGNC:31603 ENTREZ:407008 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR223"/> <bbox w="90.0" h="25.0" x="3131.0" y="6718.5"/> <glyph class="unit of information" id="_a383c3fd-3bfc-441f-a9b1-99abe1651f0e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3161.0" y="6713.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6469_sa4583" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR34C"/> <bbox w="90.0" h="25.0" x="2640.0" y="6678.5"/> <glyph class="unit of information" id="_fcdf4ae7-bb18-43f2-b9dd-ca71c9a1b4a6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2670.0" y="6673.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6470_sa4584" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 504 HUGO:MIR504 HGNC:32139 ENTREZ:574507 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR504"/> <bbox w="90.0" h="25.0" x="6440.0" y="6682.5"/> <glyph class="unit of information" id="_eed5a495-d7a8-4092-a5dd-cfa1e7e2cbf2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6470.0" y="6677.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6471_sa4585" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CyclinG1"/> <bbox w="70.0" h="25.0" x="1862.5" y="7276.5"/> </glyph> <glyph class="nucleic acid feature" id="s6472_sa4586" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CyclinG1"/> <bbox w="90.0" h="25.0" x="1685.0" y="7037.5"/> <glyph class="unit of information" id="_92ca674f-17b9-4093-ba76-2a19fd77b46d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1720.0" y="7032.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6473_sa4587" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CyclinG1"/> <bbox w="80.0" h="40.0" x="1728.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s6474_sa4588" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 155 HUGO:MIR155 HGNC:31542 ENTREZ:406947 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR155"/> <bbox w="90.0" h="25.0" x="5857.0" y="6665.5"/> <glyph class="unit of information" id="_b8cee60f-c712-489f-b383-376a7132cd9b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5887.0" y="6660.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6475_sa4589" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 92a-2 HUGO:MIR92A2 HGNC:31644 ENTREZ:407049 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR92A2"/> <bbox w="90.0" h="25.0" x="2964.0" y="6678.5"/> <glyph class="unit of information" id="_8dc89aee-9dab-44b2-b2e6-5805789bec85"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="2994.0" y="6673.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6477_sa4591" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BIM*"/> <bbox w="70.0" h="25.0" x="3414.5" y="7255.5"/> </glyph> <glyph class="nucleic acid feature" id="s6478_sa4592" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BIM*"/> <bbox w="90.0" h="25.0" x="3398.5" y="7017.5"/> <glyph class="unit of information" id="_008c8fe5-dc32-4f20-bc80-96eac3059e7e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3433.5" y="7012.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6479_sa4593" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="BIM*"/> <bbox w="80.0" h="40.0" x="3434.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s6480_sa4594" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene, E3 ubiquitin protein ligase HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MDM2"/> <bbox w="70.0" h="25.0" x="3498.5" y="7256.5"/> </glyph> <glyph class="nucleic acid feature" id="s6481_sa4595" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene, E3 ubiquitin protein ligase HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MDM2"/> <bbox w="90.0" h="25.0" x="3481.5" y="7014.5"/> <glyph class="unit of information" id="_57f3f871-ce03-4c41-9718-3aa7997d66fb"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3516.5" y="7009.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6482_sa4596" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene, E3 ubiquitin protein ligase HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="3515.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s6483_sa4597" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 32 HUGO:MIR32 HGNC:31631 ENTREZ:407036 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR32"/> <bbox w="90.0" h="25.0" x="3133.0" y="6673.5"/> <glyph class="unit of information" id="_a7be60e3-4672-4a22-a95d-5f2d7e13d22e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3163.0" y="6668.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6484_sa4598" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 483 HUGO:MIR483 HGNC:32340 ENTREZ:619552 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR483"/> <bbox w="90.0" h="25.0" x="3664.0" y="6674.5"/> <glyph class="unit of information" id="_134dd851-1289-403a-8d26-1ad60edce0a6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3694.0" y="6669.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6485_sa4599" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 149 HUGO:MIR149 HGNC:31536 ENTREZ:406941 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR149"/> <bbox w="90.0" h="25.0" x="5520.0" y="6677.5"/> <glyph class="unit of information" id="_5eefc462-c750-4189-9007-32900e3737b3"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5550.0" y="6672.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6486_sa4600" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AKT1"/> <bbox w="70.0" h="25.0" x="5604.5" y="7280.5"/> </glyph> <glyph class="nucleic acid feature" id="s6487_sa4601" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AKT1"/> <bbox w="90.0" h="25.0" x="5586.5" y="7018.5"/> <glyph class="unit of information" id="_843ad185-af00-4f38-a357-f74b72921091"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5621.5" y="7013.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6488_sa4603" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="70.0" h="25.0" x="7077.5" y="7376.5"/> </glyph> <glyph class="nucleic acid feature" id="s6489_sa4604" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="14-3-3*"/> <bbox w="90.0" h="25.0" x="7123.5" y="7043.5"/> <glyph class="unit of information" id="_2d44fe30-4b7a-4283-a6cd-30a21ca2b7df"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7158.5" y="7038.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6490_sa4606" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 375 HUGO:MIR375 HGNC:31868 ENTREZ:494324 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR375"/> <bbox w="90.0" h="25.0" x="6989.0" y="6675.5"/> <glyph class="unit of information" id="_668da023-04e4-482a-8876-8d8909f35da5"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7019.0" y="6670.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6491_sa4607" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 205 HUGO:MIR205 HGNC:31583 ENTREZ:406988 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR205"/> <bbox w="90.0" h="25.0" x="5435.0" y="6677.5"/> <glyph class="unit of information" id="_e28a8145-2184-4891-ba2c-bd09a79f6a9e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5465.0" y="6672.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6494_sa4610" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="6030.0" y="6920.0"/> <glyph class="state variable" id="_f4500b18-2c4c-481f-b452-11a9753d7974"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6066.438" y="6915.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6495_sa4611" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="90.0" h="25.0" x="5805.5" y="7133.5"/> <glyph class="unit of information" id="_0bbb3806-1b00-43ef-9996-f9daf69e5247"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5840.5" y="7128.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6496_sa4612" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="70.0" h="25.0" x="5840.5" y="7307.5"/> </glyph> <glyph class="nucleic acid feature" id="s6497_sa4613" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 145 HUGO:MIR145 HGNC:31532 ENTREZ:406937 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR145"/> <bbox w="90.0" h="25.0" x="5602.0" y="6673.5"/> <glyph class="unit of information" id="_e95489cf-1260-439f-856e-2fa8a608af83"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5632.0" y="6668.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6498_sa4614" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 330 HUGO:MIR330 HGNC:31771 ENTREZ:442902 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR330"/> <bbox w="90.0" h="25.0" x="5680.0" y="6670.5"/> <glyph class="unit of information" id="_68d5c5f6-cbbf-49f1-b223-a19b56a60320"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5710.0" y="6665.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6499_sa4615" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAB5A, member RAS oncogene family HUGO:RAB5A HGNC:9783 ENTREZ:5868 UNIPROT:P20339 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RAB5*"/> <bbox w="70.0" h="25.0" x="7204.5" y="7263.5"/> </glyph> <glyph class="nucleic acid feature" id="s6500_sa4616" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAB5A, member RAS oncogene family HUGO:RAB5A HGNC:9783 ENTREZ:5868 UNIPROT:P20339 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RAB5*"/> <bbox w="90.0" h="25.0" x="7220.5" y="7034.5"/> <glyph class="unit of information" id="_77544356-2f72-4fd0-871d-ff58ee5b544d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7255.5" y="7029.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6501_sa4617" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAB5A, member RAS oncogene family HUGO:RAB5A HGNC:9783 ENTREZ:5868 UNIPROT:P20339 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RAB5*"/> <bbox w="80.0" h="40.0" x="7363.0" y="6909.0"/> </glyph> <glyph class="nucleic acid feature" id="s6502_sa4619" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 101-1 HUGO:MIR101-1 HGNC:31488 ENTREZ:406893 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR101-1"/> <bbox w="90.0" h="25.0" x="7067.0" y="6651.5"/> <glyph class="unit of information" id="_d1c8332f-ca97-46c4-ac5d-6b352fcd8162"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7097.0" y="6646.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6503_sa4620" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 101-2 HUGO:MIR101-2 HGNC:31489 ENTREZ:406894 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR101-2"/> <bbox w="90.0" h="25.0" x="7085.0" y="6695.5"/> <glyph class="unit of information" id="_7d9f06c2-6136-408b-811e-e3c52cfd2438"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7115.0" y="6690.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6504_sa4621" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="70.0" h="25.0" x="7286.5" y="7262.5"/> </glyph> <glyph class="nucleic acid feature" id="s6505_sa4622" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 2A HUGO:ATG2A HGNC:29028 ENTREZ:23130 UNIPROT:Q2TAZ0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG2"/> <bbox w="70.0" h="25.0" x="7355.5" y="7260.5"/> </glyph> <glyph class="nucleic acid feature" id="s6507_sa4625" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 4A, cysteine peptidase HUGO:ATG4A HGNC:16489 ENTREZ:115201 UNIPROT:Q8WYN0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG4*"/> <bbox w="70.0" h="25.0" x="7508.5" y="7262.5"/> </glyph> <glyph class="nucleic acid feature" id="s6508_sa4626" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="90.0" h="25.0" x="7266.5" y="7201.5"/> <glyph class="unit of information" id="_8942c4f8-eff6-45c5-b67a-9bd63d85bb0a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7301.5" y="7196.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6509_sa4627" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 2A HUGO:ATG2A HGNC:29028 ENTREZ:23130 UNIPROT:Q2TAZ0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG2"/> <bbox w="90.0" h="25.0" x="7350.5" y="7200.5"/> <glyph class="unit of information" id="_f32202fd-5a45-4128-9dea-8db39468680b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7385.5" y="7195.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6510_sa4629" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 4A, cysteine peptidase HUGO:ATG4A HGNC:16489 ENTREZ:115201 UNIPROT:Q8WYN0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG4*"/> <bbox w="90.0" h="25.0" x="7502.5" y="7207.5"/> <glyph class="unit of information" id="_ad6477ac-0169-4e69-af49-f7cba5365736"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7537.5" y="7202.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6511_sa4631" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 2A HUGO:ATG2A HGNC:29028 ENTREZ:23130 UNIPROT:Q2TAZ0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG2"/> <bbox w="80.0" h="40.0" x="7526.0" y="6908.0"/> </glyph> <glyph class="macromolecule" id="s6512_sa4632" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 12 HUGO:ATG12 HGNC:588 ENTREZ:9140 UNIPROT:O94817 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 References_end </body> </html> </notes> <label text="ATG12"/> <bbox w="80.0" h="40.0" x="7613.0" y="6909.0"/> </glyph> <glyph class="nucleic acid feature" id="s6514_sa4635" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 130a HUGO:MIR130A HGNC:31514 ENTREZ:406919 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR130A"/> <bbox w="90.0" h="25.0" x="7343.0" y="6670.5"/> <glyph class="unit of information" id="_d23e95ba-dec0-4f12-a06b-6c4811f391bb"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7373.0" y="6665.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6515_sa4640" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 512-1 HUGO:MIR512-1 HGNC:32090 ENTREZ:574458 microRNA 512-2 HUGO:MIR512-2 HGNC:32091 ENTREZ:574459 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR512*"/> <bbox w="90.0" h="25.0" x="6520.0" y="6679.5"/> <glyph class="unit of information" id="_0d35d7f0-6689-4102-a04a-528b623b42a6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6550.0" y="6674.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6516_sa4641" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 512-1 HUGO:MIR512-1 HGNC:32090 ENTREZ:574458 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR512-1"/> <bbox w="90.0" h="25.0" x="6568.0" y="6634.5"/> <glyph class="unit of information" id="_92b3ab72-90d8-485f-9a5a-82052e3e0057"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6598.0" y="6629.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6517_sa4642" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 512-2 HUGO:MIR512-2 HGNC:32091 ENTREZ:574459 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR512-2"/> <bbox w="90.0" h="25.0" x="6485.0" y="6635.5"/> <glyph class="unit of information" id="_c1f5616c-77d0-4a7a-9454-dbc5e230649b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6515.0" y="6630.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6518_sa4643" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="Caspase10*"/> <bbox w="70.0" h="25.0" x="4520.5" y="7263.5"/> </glyph> <glyph class="nucleic acid feature" id="s6519_sa4644" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:TRAIL_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="Caspase10*"/> <bbox w="90.0" h="25.0" x="4516.5" y="7151.5"/> <glyph class="unit of information" id="_9e621513-f71f-4c89-aa81-e8f754b89241"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4551.5" y="7146.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6520_sa4646" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 186 HUGO:MIR186 HGNC:31557 ENTREZ:406962 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR186"/> <bbox w="90.0" h="25.0" x="4404.0" y="6684.5"/> <glyph class="unit of information" id="_dac2192d-0374-42bb-b761-56e5785dd57e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4434.0" y="6679.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6525_sa4647" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDK6"/> <bbox w="70.0" h="25.0" x="4369.5" y="7267.5"/> </glyph> <glyph class="nucleic acid feature" id="s6526_sa4648" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sirtuin 1 HUGO:SIRT1 HGNC:14929 ENTREZ:23411 UNIPROT:Q96EB6 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="SIRT1"/> <bbox w="70.0" h="25.0" x="1759.5" y="7267.5"/> </glyph> <glyph class="nucleic acid feature" id="s6527_sa4650" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 31 HUGO:MIR31 HGNC:31630 ENTREZ:407035 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR31"/> <bbox w="90.0" h="25.0" x="4211.0" y="6683.5"/> <glyph class="unit of information" id="_6a5b3148-93ec-45bc-a26f-eeb97891653f"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4241.0" y="6678.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6528_sa4651" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 2 HUGO:E2F2 HGNC:3114 ENTREZ:1870 UNIPROT:Q14209 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="E2F2"/> <bbox w="70.0" h="25.0" x="4294.5" y="7268.5"/> </glyph> <glyph class="nucleic acid feature" id="s6529_sa4652" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 2 HUGO:E2F2 HGNC:3114 ENTREZ:1870 UNIPROT:Q14209 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="E2F2"/> <bbox w="90.0" h="25.0" x="4310.5" y="7040.5"/> <glyph class="unit of information" id="_c28e7fad-456b-4116-a0c1-c7c692676d60"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4345.5" y="7035.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6530_sa4653" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 2 HUGO:E2F2 HGNC:3114 ENTREZ:1870 UNIPROT:Q14209 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="E2F2"/> <bbox w="80.0" h="40.0" x="4020.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s6531_sa4655" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN2A"/> <bbox w="90.0" h="25.0" x="4091.5" y="7048.5"/> <glyph class="unit of information" id="_dbda96c5-b43a-47ba-bf9a-c0e73acee85a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4126.5" y="7043.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6532_sa4656" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2A HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN2A"/> <bbox w="80.0" h="40.0" x="3917.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s6533_sa4657" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="CDKN1A"/> <bbox w="80.0" h="40.0" x="2370.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s6534_sa4658" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 128-1 HUGO:MIR128-1 HGNC:31510 ENTREZ:406915 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR128-1"/> <bbox w="90.0" h="25.0" x="3788.0" y="6631.5"/> <glyph class="unit of information" id="_1aef66c8-9f13-4bb0-91ff-28a0954fbfe2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3818.0" y="6626.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6535_sa4659" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 128-2 HUGO:MIR128-2 HGNC:31511 ENTREZ:406916 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR128-2"/> <bbox w="90.0" h="25.0" x="3712.0" y="6633.5"/> <glyph class="unit of information" id="_944d5edf-0519-414e-a6d5-2f318a5a6e47"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3742.0" y="6628.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6536_sa4660" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 128-1 HUGO:MIR128-1 HGNC:31510 ENTREZ:406915 microRNA 128-2 HUGO:MIR128-2 HGNC:31511 ENTREZ:406916 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR128*"/> <bbox w="90.0" h="25.0" x="3748.0" y="6674.5"/> <glyph class="unit of information" id="_75a958b3-7e2f-45c6-9f56-b0a2bcbf5ff0"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="3778.0" y="6669.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6537_sa4662" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA let-7e HUGO:MIRLET7E HGNC:31482 ENTREZ:406887 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIRLET7E"/> <bbox w="90.0" h="25.0" x="6085.0" y="6615.5"/> <glyph class="unit of information" id="_23740c5a-ddae-479c-9d1d-5f55573a3f91"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6115.0" y="6610.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6538_sa4663" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA let-7c HUGO:MIRLET7C HGNC:31480 ENTREZ:406885 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIRLET7C"/> <bbox w="90.0" h="25.0" x="5934.0" y="6617.5"/> <glyph class="unit of information" id="_d482cf75-2497-4d99-b67e-86004f8feeae"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5964.0" y="6612.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6539_sa4664" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA let-7g HUGO:MIRLET7G HGNC:31485 ENTREZ:406890 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIRLET7G"/> <bbox w="90.0" h="25.0" x="6012.0" y="6620.5"/> <glyph class="unit of information" id="_4fc1e8e0-3adf-46ea-9e8a-730d8e51b6fb"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6042.0" y="6615.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6540_sa4665" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA let-7e HUGO:MIRLET7E HGNC:31482 ENTREZ:406887 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIRLET7*"/> <bbox w="90.0" h="25.0" x="6027.0" y="6663.5"/> <glyph class="unit of information" id="_c6d2195a-5aac-463a-b55c-40f77067be49"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6057.0" y="6658.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6541_sa4667" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FAF1"/> <bbox w="70.0" h="25.0" x="4730.5" y="7281.5"/> </glyph> <glyph class="nucleic acid feature" id="s6542_sa4668" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="FAF1"/> <bbox w="90.0" h="25.0" x="4726.5" y="7024.5"/> <glyph class="unit of information" id="_d9c410bf-ed6c-4075-ae63-78134a6a9cc8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4761.5" y="7019.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6543_sa4670" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 24-1 HUGO:MIR24-1 HGNC:31607 ENTREZ:407012 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR24"/> <bbox w="90.0" h="25.0" x="5291.0" y="6671.5"/> <glyph class="unit of information" id="_76080995-08e8-42d4-8359-b2a0f8e01682"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5321.0" y="6666.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6544_sa4671" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 181a-1 HUGO:MIR181A1 HGNC:31590 ENTREZ:406995 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR181A"/> <bbox w="90.0" h="25.0" x="6269.0" y="6683.5"/> <glyph class="unit of information" id="_2c5b3e5a-b638-4d05-b6b5-720883a3b9c2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6299.0" y="6678.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6545_sa4672" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-51 like autophagy activating kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ULK1"/> <bbox w="70.0" h="25.0" x="6820.5" y="7256.5"/> </glyph> <glyph class="nucleic acid feature" id="s6546_sa4673" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-51 like autophagy activating kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ULK2"/> <bbox w="70.0" h="25.0" x="6893.5" y="7254.5"/> </glyph> <glyph class="nucleic acid feature" id="s6547_sa4674" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG16*"/> <bbox w="70.0" h="25.0" x="6973.5" y="7254.5"/> </glyph> <glyph class="nucleic acid feature" id="s6548_sa4675" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG5"/> <bbox w="70.0" h="25.0" x="7044.5" y="7256.5"/> </glyph> <glyph class="nucleic acid feature" id="s6549_sa4676" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 10 HUGO:ATG10 HGNC:20315 ENTREZ:83734 UNIPROT:Q9H0Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG10"/> <bbox w="70.0" h="25.0" x="7117.5" y="7258.5"/> </glyph> <glyph class="nucleic acid feature" id="s6550_sa4677" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-51 like autophagy activating kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ULK1"/> <bbox w="90.0" h="25.0" x="6831.5" y="7167.5"/> <glyph class="unit of information" id="_eb0cb0e4-de83-4588-96d4-5afd008c075c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6866.5" y="7162.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6551_sa4678" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: unc-51 like autophagy activating kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ULK2"/> <bbox w="90.0" h="25.0" x="6902.5" y="7162.5"/> <glyph class="unit of information" id="_e50f9fd2-7bbe-4d0e-be0a-1e9703045fed"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6937.5" y="7157.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6552_sa4679" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG16*"/> <bbox w="90.0" h="25.0" x="6971.5" y="7159.5"/> <glyph class="unit of information" id="_8f87bb07-de07-4b8c-ba70-c6e4a6dda68f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7006.5" y="7154.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6553_sa4680" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG5"/> <bbox w="90.0" h="25.0" x="7042.5" y="7170.5"/> <glyph class="unit of information" id="_7ffbfbe2-2dd7-480e-9710-d9b13c9854e6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7077.5" y="7165.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6554_sa4681" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 10 HUGO:ATG10 HGNC:20315 ENTREZ:83734 UNIPROT:Q9H0Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="ATG10"/> <bbox w="90.0" h="25.0" x="7118.5" y="7163.5"/> <glyph class="unit of information" id="_d6c1fc01-3e82-4d7b-b860-e1ed76f5dd4d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7153.5" y="7158.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6555_sa4682" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 885 HUGO:MIR885 HGNC:33659 ENTREZ:100126334 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR885"/> <bbox w="90.0" h="25.0" x="6591.0" y="6679.5"/> <glyph class="unit of information" id="_170e7572-3eef-4cff-8370-f51ceddd816b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6621.0" y="6674.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6556_sa4683" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 30a HUGO:MIR30A HGNC:31624 ENTREZ:407029 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR30A"/> <bbox w="90.0" h="25.0" x="6671.0" y="6679.5"/> <glyph class="unit of information" id="_9131e218-3548-4bc1-b8d7-d4918e6ace57"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6701.0" y="6674.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6557_sa4684" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 374a HUGO:MIR374A HGNC:31788 ENTREZ:442919 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR374A"/> <bbox w="90.0" h="25.0" x="6748.0" y="6677.5"/> <glyph class="unit of information" id="_e70412e4-7d96-4d72-911b-1e443a3af29a"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6778.0" y="6672.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6558_sa4685" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 376b HUGO:MIR376B HGNC:32066 ENTREZ:574435 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR376B"/> <bbox w="90.0" h="25.0" x="6829.0" y="6676.5"/> <glyph class="unit of information" id="_c4074ee3-e7ee-40b8-86ab-2753a958a26e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6859.0" y="6671.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s6559_sa4686" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 519a-1 HUGO:MIR519A1 HGNC:32128 ENTREZ:574496 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR519A"/> <bbox w="90.0" h="25.0" x="6905.0" y="6675.5"/> <glyph class="unit of information" id="_bd63ffe1-0e63-4f39-b02d-13c614c1f006"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="6935.0" y="6670.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s6566_sa4690" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 PMID:24257061 References_end </body> </html> </notes> <label text="ATG16*"/> <bbox w="80.0" h="40.0" x="6934.0" y="6920.0"/> </glyph> <glyph class="macromolecule" id="s6567_sa4349" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 10 HUGO:ATG10 HGNC:20315 ENTREZ:83734 UNIPROT:Q9H0Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:24070470 References_end </body> </html> </notes> <label text="ATG10"/> <clone/> <bbox w="80.0" h="40.0" x="11690.5" y="2518.5"/> </glyph> <glyph class="macromolecule" id="s6567_sa4692" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 10 HUGO:ATG10 HGNC:20315 ENTREZ:83734 UNIPROT:Q9H0Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:24070470 References_end </body> </html> </notes> <label text="ATG10"/> <clone/> <bbox w="80.0" h="40.0" x="7100.0" y="6920.0"/> </glyph> <glyph class="macromolecule" id="s6576_sa4693" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 9A HUGO:ATG9A HGNC:22408 ENTREZ:79065 UNIPROT:Q7Z3C6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:24257061 References_end </body> </html> </notes> <label text="ATG9A"/> <bbox w="80.0" h="40.0" x="2275.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s6577_sa4694" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 60kDa protein 1 (chaperonin) HUGO:HSPD1 HGNC:5261 ENTREZ:3329 UNIPROT:P10809 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HSP60*"/> <bbox w="80.0" h="40.0" x="2186.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s6578_sa4696" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="2980.0" y="6900.0"/> </glyph> <glyph class="complex" id="s6593_csa477" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG16L1:ATG9* Identifiers_end References_begin: PMID:24257061 References_end </body> </html> </notes> <label text="ATG9*:ATG16L1"/> <bbox w="96.0" h="116.0" x="11368.5" y="3109.5"/> <glyph class="macromolecule" id="s6591_sa4697"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 9A HUGO:ATG9A HGNC:22408 ENTREZ:79065 UNIPROT:Q7Z3C6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:24257061 References_end </body> </html> </notes> <label text="ATG9*"/> <bbox w="80.0" h="40.0" x="11378.046" y="3117.2273"/> </glyph> <glyph class="macromolecule" id="s6592_sa4699"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:24257061 PMID:23725295 PMID:24070470 PMID:PMID:24257061 References_end </body> </html> </notes> <label text="ATG16L1"/> <bbox w="80.0" h="40.0" x="11378.046" y="3160.2273"/> </glyph> </glyph> <glyph class="macromolecule" id="s6594_sa4700" compartmentRef="c32_ca33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: vesicle-associated membrane protein 3 HUGO:VAMP3 HGNC:12644 ENTREZ:9341 UNIPROT:Q15836 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="VAMP3"/> <bbox w="80.0" h="40.0" x="11291.5" y="2102.5"/> </glyph> <glyph class="macromolecule" id="s6227_sa4405" compartmentRef="c32_ca33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 9A HUGO:ATG9A HGNC:22408 ENTREZ:79065 UNIPROT:Q7Z3C6 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:24257061 References_end </body> </html> </notes> <label text="ATG9*"/> <bbox w="80.0" h="40.0" x="11122.5" y="2243.5"/> </glyph> <glyph class="phenotype" id="s6611_sa4701" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:22841746 References_end </body> </html> </notes> <label text="Oxidative Phosphorylation"/> <bbox w="191.0" h="36.0" x="2860.25" y="5125.0"/> </glyph> <glyph class="phenotype" id="s6616_sa4702" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22841746 References_end </body> </html> </notes> <label text="Nucleotide Synthesis"/> <bbox w="80.0" h="30.0" x="620.0" y="1595.0"/> </glyph> <glyph class="macromolecule" id="s6617_sa4703" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase 1 (muscle) HUGO:GYS1 HGNC:4706 ENTREZ:2997 UNIPROT:P13807 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:22841746 References_end </body> </html> </notes> <label text="GYS1"/> <bbox w="80.0" h="40.0" x="376.0" y="550.0"/> <glyph class="state variable" id="_47ac9b17-3b6d-46ea-a148-88afce5c2952"> <state value="" variable=""/> <bbox w="10.0" 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id="_e42dcb93-6acd-40de-ba78-b505ec66d6f0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="590.625" y="557.2157"/> </glyph> </glyph> <glyph class="phenotype" id="s6631_sa4705" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:27048813 References_end </body> </html> </notes> <label text="Survival"/> <bbox w="80.0" h="30.0" x="5730.0" y="2235.0"/> </glyph> <glyph class="complex" id="s6200_csa457" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG3:LC3-I*:Phosphatidyl ethanolamine Identifiers_end References_begin: 23725295 PMID:24070470 PMID:22166994 PMID:23030059 PMID:23725295 References_end </body> </html> </notes> <label text="ATG8*:ATG10"/> <bbox w="284.0" h="125.0" x="11067.75" y="3117.5833"/> <glyph class="macromolecule" id="s6656_sa4392"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="LC3-I*"/> <bbox w="80.0" h="40.0" x="11083.096" y="3131.3142"/> <glyph class="unit of information" id="_b6611286-7074-4ab4-bba1-d80b226204c1"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11098.096" y="3126.3142"/> </glyph> </glyph> <glyph class="simple chemical" id="s6199_sa4393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:16038 </body> </html> </notes> <label text="Phosphatidyl ethanolamine"/> <bbox w="160.0" h="33.0" x="11174.096" y="3153.3142"/> </glyph> <glyph class="macromolecule" id="s6657_sa4456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 3 HUGO:ATG3 HGNC:20962 ENTREZ:64422 UNIPROT:Q9NT62 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:23725295 PMID:23301705 PMID:23377657 PMID:24070470 References_end </body> </html> </notes> <label text="ATG3"/> <bbox w="80.0" h="40.0" x="11078.643" y="3180.6428"/> </glyph> </glyph> <glyph class="simple chemical" id="s6792_sa3055" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16027 KEGGCOMPOUND:C00020 CAS:61-19-8 Identifiers_end </body> </html> </notes> <label text="AMP"/> <bbox w="70.0" h="25.0" x="5809.0" y="5869.25"/> </glyph> <glyph class="macromolecule" id="s6818_sa1070" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 mitogen-activated protein kinase 1 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ERK*"/> <clone/> <bbox w="80.0" h="40.0" x="8725.0" y="2545.0"/> </glyph> <glyph class="macromolecule" id="s6818_sa1285" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 mitogen-activated protein kinase 1 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ERK*"/> <clone/> <bbox w="80.0" h="40.0" x="4784.0" y="2590.0"/> </glyph> <glyph class="macromolecule" id="s6818_sa1429" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 mitogen-activated protein kinase 1 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="ERK*"/> <clone/> <bbox w="80.0" h="40.0" x="6718.666" y="3677.7236"/> </glyph> <glyph class="source and sink" id="s6893_sa3652" compartmentRef="c1_ca1"> <label text="s4882"/> <clone/> <bbox w="30.0" h="30.0" x="4185.0" y="1689.0"/> </glyph> <glyph class="source and sink" id="s6893_sa3658" compartmentRef="c1_ca1"> <label text="s4882"/> <clone/> <bbox w="30.0" h="30.0" x="4065.0" y="1685.0"/> </glyph> <glyph class="macromolecule" id="s2350_sa1166" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: egl nine homolog 3 (C. elegans) HUGO:EGLN3 HGNC:14661 ENTREZ:112399 UNIPROT:Q9H6Z9 Identifiers_end References_begin: synonym:PHD3 References_end </body> </html> </notes> <label text="EGLN3"/> <bbox w="80.0" h="40.0" x="7220.0" y="6060.0"/> </glyph> <glyph class="macromolecule" id="s6947_sa3998" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas cell surface death receptor HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:12724420 PMID:23069999 Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis PMID:19597341 PMID:16498403 References_end </body> </html> </notes> <label text="FAS"/> <bbox w="80.0" h="50.0" x="7960.0" y="185.0"/> <glyph class="state variable" id="_1c86a480-5aac-4dbb-89c6-5a6a6af75156"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8035.0" y="194.64465"/> </glyph> <glyph class="unit of information" id="_88ab9823-d8a4-4f5c-9c8a-aa2f0ff24571"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7977.5" y="180.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s6948_sa3997" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas ligand (TNF superfamily, member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:RCD_GENES Maps_Modules_end References_begin: HUGo:FASLG References_end </body> </html> </notes> <label text="FASLG"/> <bbox w="80.0" h="40.0" x="8010.0" y="130.0"/> </glyph> <glyph class="simple chemical" id="s6957_sa3698" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="H2O"/> <clone/> <bbox w="70.0" h="25.0" x="2617.5" y="1472.5"/> </glyph> <glyph class="simple chemical" id="s6957_sa3700" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="H2O"/> <clone/> <bbox w="70.0" h="25.0" x="2627.5" y="1732.5"/> </glyph> <glyph class="simple chemical" id="s6957_sa5328" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="H2O"/> <clone/> <bbox w="70.0" h="25.0" x="8845.0" y="1047.5"/> </glyph> <glyph class="simple chemical" id="s6957_sa5331" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="H2O"/> <clone/> <bbox w="70.0" h="25.0" x="8640.0" y="1122.5"/> </glyph> <glyph class="simple chemical" id="s6957_sa5332" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="H2O"/> <clone/> <bbox w="70.0" h="25.0" x="8755.0" y="1117.5"/> </glyph> <glyph class="simple chemical" id="s6957_sa5359" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="H2O"/> <clone/> <bbox w="70.0" h="25.0" x="8437.5" y="996.25"/> </glyph> <glyph class="macromolecule" id="s6958_sa3716" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanylate cyclase 1, soluble, alpha 2 HUGO:GUCY1A2 HGNC:4684 ENTREZ:2977 UNIPROT:P33402 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: Guanylate cyclase soluble PMID:12404124 NO was found to be mediated through stimulation of guanylate cyclase and to require activation of protein kinase G PMID:16716889 References_end </body> </html> </notes> <label text="GUCY*"/> <clone/> <bbox w="80.0" h="40.0" x="2190.0" y="1630.0"/> </glyph> <glyph class="macromolecule" id="s6958_sa3720" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanylate cyclase 1, soluble, alpha 2 HUGO:GUCY1A2 HGNC:4684 ENTREZ:2977 UNIPROT:P33402 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: Guanylate cyclase soluble PMID:12404124 NO was found to be mediated through stimulation of guanylate cyclase and to require activation of protein kinase G PMID:16716889 References_end </body> </html> </notes> <label text="GUCY*"/> <clone/> <bbox w="80.0" h="40.0" x="2190.0" y="1480.0"/> </glyph> <glyph class="macromolecule" id="s6959_sa3724" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cGMP-dependent, type I HUGO:PRKG1 HGNC:9414 ENTREZ:5592 UNIPROT:Q13976 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:12404124 Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis. PMID:16716889 References_end </body> </html> </notes> <label text="PRKG1"/> <clone/> <bbox w="80.0" h="40.0" x="2175.0" y="1300.0"/> </glyph> <glyph class="macromolecule" id="s6959_sa3725" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, cGMP-dependent, type I HUGO:PRKG1 HGNC:9414 ENTREZ:5592 UNIPROT:Q13976 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:12404124 Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis. PMID:16716889 References_end </body> </html> </notes> <label text="PRKG1"/> <clone/> <bbox w="80.0" h="40.0" x="2177.5" y="1395.0"/> </glyph> <glyph class="macromolecule" id="s6960_sa3738" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: K(lysine) acetyltransferase 5 HUGO:KAT5 HGNC:5275 ENTREZ:10524 UNIPROT:Q92993 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21029305 A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β) References_end </body> </html> </notes> <label text="cPLA2*"/> <clone/> <bbox w="80.0" h="40.0" x="3342.5" y="1675.0"/> </glyph> <glyph class="macromolecule" id="s6960_sa3744" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: K(lysine) acetyltransferase 5 HUGO:KAT5 HGNC:5275 ENTREZ:10524 UNIPROT:Q92993 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21029305 A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β) References_end </body> </html> </notes> <label text="cPLA2*"/> <clone/> <bbox w="80.0" h="40.0" x="3340.0" y="1810.0"/> </glyph> <glyph class="macromolecule" id="s6978_sa3868" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <clone/> <bbox w="110.0" h="40.0" x="6845.0" y="320.0"/> <glyph class="state variable" id="_2f5a73a3-2361-4025-aa2e-7475f12d5ca3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6840.0" y="326.71573"/> </glyph> </glyph> <glyph class="macromolecule" id="s6978_sa4010" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <clone/> <bbox w="110.0" h="40.0" x="7755.0" y="750.0"/> <glyph class="state variable" id="_76a69177-0164-4685-a085-ff882a5ede20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7750.0" y="756.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="s6979_sa1896" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28462525 References_end </body> </html> </notes> <label text="Caspase8*"/> <clone/> <bbox w="80.0" h="40.0" x="7250.0" y="4090.0"/> <glyph class="state variable" id="_ff6a2793-e963-4485-baaf-650cf56784c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7245.0" y="4096.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s6979_sa3857" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE 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apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE Maps_Modules_end References_begin: PMID:28462525 References_end </body> </html> </notes> <label text="Caspase8*"/> <clone/> <bbox w="80.0" h="40.0" x="7045.5" y="1004.0"/> <glyph class="state variable" id="_73583be6-d0a5-43c8-98ad-2db222f31818"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7040.5" y="1010.7157"/> </glyph> </glyph> <glyph class="complex" id="s6980_csa394" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:RBX1 Identifiers_end References_begin: RBX1:CUL3 19427028 Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. 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References_end </body> </html> </notes> <label text="CUL3:RBX1"/> <clone/> <bbox w="100.0" h="120.0" x="7110.0" y="480.0"/> <glyph class="macromolecule" id="s6981_sa3880"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="CUL3"/> <clone/> <bbox w="80.0" h="40.0" x="7120.0" y="530.0"/> </glyph> <glyph class="macromolecule" id="s6982_sa3881"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ring-box 1, E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:TRAIL_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="RBX1"/> <clone/> <bbox w="80.0" h="40.0" x="7120.0" y="490.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s6984_sa1174" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: egl nine homolog 1 (C. elegans) HUGO:EGLN1 HGNC:1232 ENTREZ:54583 UNIPROT:Q9GZT9 egl nine homolog 2 (C. elegans) HUGO:EGLN2 HGNC:14660 ENTREZ:112398 UNIPROT:Q96KS0 egl nine homolog 3 (C. elegans) HUGO:EGLN3 HGNC:14661 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16284 KEGGCOMPOUND:C00131 CAS:1927-31-7 Identifiers_end </body> </html> </notes> <label text="dATP"/> <clone/> <bbox w="70.0" h="25.0" x="2072.875" y="2785.5"/> </glyph> <glyph class="simple chemical" id="s7161_sa3092" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16284 KEGGCOMPOUND:C00131 CAS:1927-31-7 Identifiers_end </body> </html> </notes> <label text="dATP"/> <clone/> <bbox w="70.0" h="25.0" x="6429.125" y="5835.25"/> </glyph> <glyph class="macromolecule" id="s7162_sa4351" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 4D, cysteine peptidase HUGO:ATG4D HGNC:20789 ENTREZ:84971 UNIPROT:Q86TL0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:19549685 References_end </body> </html> </notes> <label text="ATG4*"/> <clone/> <bbox w="80.0" h="40.0" x="10509.25" y="2863.0833"/> </glyph> <glyph class="macromolecule" id="s7162_sa4633" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 4D, cysteine peptidase HUGO:ATG4D HGNC:20789 ENTREZ:84971 UNIPROT:Q86TL0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:19549685 References_end </body> </html> </notes> <label text="ATG4*"/> <clone/> <bbox w="80.0" h="40.0" x="7700.0" y="6910.0"/> </glyph> <glyph class="simple chemical" id="s7163_sa4363" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16038 Identifiers_end References_begin: PMID:23301705 PMID:24070470 References_end </body> </html> </notes> <label text="Phosphatidyl ethanolamine"/> <bbox w="160.0" h="33.0" x="10971.25" y="3067.5833"/> </glyph> <glyph class="macromolecule" id="s7164_sa4398" compartmentRef="c31_ca31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 16-like 1 (S. cerevisiae) HUGO:ATG16L1 HGNC:21498 ENTREZ:55054 UNIPROT:Q676U5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 PMID:24070470 PMID:24257061 References_end </body> </html> </notes> <label text="ATG16*"/> <bbox w="80.0" h="40.0" x="11058.5" y="2925.5"/> </glyph> <glyph class="complex" id="s7166_csa141" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN1:Ca2+ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="102.0" h="86.0" x="6858.25" y="2240.5"/> <glyph class="macromolecule" id="s7167_sa1452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="80.0" h="40.0" x="6868.25" y="2269.5"/> </glyph> <glyph class="simple chemical" id="s7168_sa1453"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="25.0" h="25.0" x="6918.75" y="2244.0"/> </glyph> </glyph> <glyph class="complex" id="s7166_csa405" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN1:Ca2+ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="102.0" h="86.0" x="6749.0" y="3157.0"/> <glyph class="macromolecule" id="s7167_sa3974"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="80.0" h="40.0" x="6759.0" y="3186.0"/> </glyph> <glyph class="simple chemical" id="s7168_sa3975"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="25.0" h="25.0" x="6809.5" y="3160.5"/> </glyph> </glyph> <glyph class="complex" id="s7166_csa407" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN1:Ca2+ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="102.0" h="86.0" x="4729.0" y="3427.0"/> <glyph class="macromolecule" id="s7167_sa3980"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="CAPN1"/> <clone/> <bbox w="80.0" h="40.0" x="4739.0" y="3456.0"/> </glyph> <glyph class="simple chemical" id="s7168_sa3981"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="25.0" h="25.0" x="4789.5" y="3430.5"/> </glyph> </glyph> <glyph class="complex" id="s7169_csa142" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN2:Ca2+_ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="98.0" h="84.0" x="6970.25" y="2241.5"/> <glyph class="macromolecule" id="s7170_sa1454"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: synonym:m-calpain References_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="80.0" h="40.0" x="6980.25" y="2267.5"/> </glyph> <glyph class="simple chemical" id="s7171_sa1455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+_"/> <clone/> <bbox w="25.0" h="25.0" x="7031.75" y="2243.5"/> </glyph> </glyph> <glyph class="complex" id="s7169_csa403" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN2:Ca2+_ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="99.0" h="92.0" x="6150.5" y="3664.0"/> <glyph class="macromolecule" id="s7170_sa3969"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: synonym:m-calpain References_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="80.0" h="40.0" x="6160.5" y="3690.0"/> </glyph> <glyph class="simple chemical" id="s7171_sa3970"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+_"/> <clone/> <bbox w="25.0" h="25.0" x="6212.0" y="3666.0"/> </glyph> </glyph> <glyph class="complex" id="s7169_csa404" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN2:Ca2+_ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="98.0" h="84.0" x="6861.0" y="3158.0"/> <glyph class="macromolecule" id="s7170_sa3972"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: synonym:m-calpain References_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="80.0" h="40.0" x="6871.0" y="3184.0"/> </glyph> <glyph class="simple chemical" id="s7171_sa3973"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+_"/> <clone/> <bbox w="25.0" h="25.0" x="6922.5" y="3160.0"/> </glyph> </glyph> <glyph class="complex" id="s7169_csa406" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAPN2:Ca2+_ Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="98.0" h="84.0" x="4841.0" y="3428.0"/> <glyph class="macromolecule" id="s7170_sa3978"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: synonym:m-calpain References_end </body> </html> </notes> <label text="CAPN2"/> <clone/> <bbox w="80.0" h="40.0" x="4851.0" y="3454.0"/> </glyph> <glyph class="simple chemical" id="s7171_sa3979"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 </body> </html> </notes> <label text="Ca2+_"/> <clone/> <bbox w="25.0" h="25.0" x="4902.5" y="3430.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7173_sa1987" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16651 KEGGCOMPOUND:C00186 CAS:79-33-4 Identifiers_end </body> </html> </notes> <label text="lactate"/> <bbox w="70.0" h="25.0" x="45.0" y="2487.5"/> </glyph> <glyph class="simple chemical" id="s7174_sa858" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17634 KEGGCOMPOUND:C00031 CAS:50-99-7 Identifiers_end References_begin: PMID:12546687 References_end </body> </html> </notes> <label text="glucose"/> <bbox w="70.0" h="25.0" x="45.0" y="647.5"/> </glyph> <glyph class="simple chemical" id="s7261_sa1978" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18050 KEGGCOMPOUND:C00064 CAS:56-85-9 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="L-glutamine"/> <bbox w="85.0" h="32.5" x="37.5" y="3343.75"/> </glyph> <glyph class="simple chemical" id="s7308_sa910" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15346 KEGGCOMPOUND:C00010 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="coenzyme A"/> <clone/> <bbox w="89.53373" h="23.101194" x="859.7098" y="2715.024"/> </glyph> <glyph class="simple chemical" id="s7308_sa2705" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15346 KEGGCOMPOUND:C00010 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="coenzyme A"/> <clone/> <bbox w="70.0" h="25.0" x="858.74347" y="2990.125"/> </glyph> <glyph class="simple chemical" id="s7308_sa4279" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15346 KEGGCOMPOUND:C00010 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis References_end </body> </html> </notes> <label text="coenzyme A"/> <clone/> <bbox w="85.0" h="22.5" x="1084.2435" y="2815.625"/> </glyph> <glyph class="macromolecule" id="s7310_sa2797" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NME/NM23 nucleoside diphosphate kinase 1 HUGO:NME1 HGNC:7849 ENTREZ:4830 UNIPROT:P15531 NME/NM23 nucleoside diphosphate kinase 2 HUGO:NME2 HGNC:7850 ENTREZ:4831 UNIPROT:P22392 NME/NM23 nucleoside diphosphate kinase 3 HUGO:NME3 HGNC:7851 ENTREZ:4832 UNIPROT:Q13232 NME/NM23 nucleoside diphosphate kinase 4 HUGO:NME4 HGNC:7852 ENTREZ:4833 UNIPROT:O00746 NME/NM23 family member 5 HUGO:NME5 HGNC:7853 ENTREZ:8382 UNIPROT:P56597 NME/NM23 nucleoside diphosphate kinase 6 HUGO:NME6 HGNC:20567 ENTREZ:10201 UNIPROT:O75414 NME/NM23 family member 7 HUGO:NME7 HGNC:20461 ENTREZ:29922 UNIPROT:Q9Y5B8 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="NME*"/> <clone/> <bbox w="80.0" h="40.0" x="1900.0" y="2640.0"/> </glyph> <glyph class="macromolecule" id="s7310_sa4277" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NME/NM23 nucleoside diphosphate kinase 1 HUGO:NME1 HGNC:7849 ENTREZ:4830 UNIPROT:P15531 NME/NM23 nucleoside diphosphate kinase 2 HUGO:NME2 HGNC:7850 ENTREZ:4831 UNIPROT:P22392 NME/NM23 nucleoside diphosphate kinase 3 HUGO:NME3 HGNC:7851 ENTREZ:4832 UNIPROT:Q13232 NME/NM23 nucleoside diphosphate kinase 4 HUGO:NME4 HGNC:7852 ENTREZ:4833 UNIPROT:O00746 NME/NM23 family member 5 HUGO:NME5 HGNC:7853 ENTREZ:8382 UNIPROT:P56597 NME/NM23 nucleoside diphosphate kinase 6 HUGO:NME6 HGNC:20567 ENTREZ:10201 UNIPROT:O75414 NME/NM23 family member 7 HUGO:NME7 HGNC:20461 ENTREZ:29922 UNIPROT:Q9Y5B8 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="NME*"/> <clone/> <bbox w="80.0" h="40.0" x="1930.0" y="2930.0"/> </glyph> <glyph class="macromolecule" id="s7311_sa2270" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18191 KEGGCOMPOUND:C00343 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="80.0" h="40.0" x="11596.5" y="1666.0"/> <glyph class="state variable" id="_de5f9522-8d45-4b51-a593-80103ff5f5ae"> <state value="-S-S-" variable=""/> <bbox w="35.0" h="10.0" x="11619.0" y="1661.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7311_sa2812" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18191 KEGGCOMPOUND:C00343 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="80.0" h="40.0" x="1960.0" y="2530.0"/> <glyph class="state variable" id="_b559acc9-767b-4283-aefd-206e57d172a5"> <state value="-S-S-" variable=""/> <bbox w="35.0" h="10.0" x="1982.5" y="2525.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7311_sa4281" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18191 KEGGCOMPOUND:C00343 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="80.0" h="40.0" x="2000.0" y="2840.0"/> <glyph class="state variable" id="_fe7b02df-1388-446e-8a9a-2c80a8345f79"> <state value="-S-S-" variable=""/> <bbox w="35.0" h="10.0" x="2022.5" y="2835.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7375_sa2328" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30413 Identifiers_end </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="7377.5" y="7732.5"/> </glyph> <glyph class="macromolecule" id="s7378_sa13" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <clone/> <bbox w="80.0" h="40.0" x="6380.0" y="3220.0"/> <glyph class="state variable" id="_77b8257b-7cc0-4393-b5e4-aed9281dec35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6431.5684" y="3215.0"/> </glyph> <glyph class="unit of information" id="_17b2beca-6917-4c81-ab08-bc313f9ea245"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6395.0" y="3215.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7378_sa3966" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:21887410 References_end </body> </html> </notes> <label text="cleaved~AIFM1*"/> <clone/> <bbox w="80.0" h="40.0" x="6160.0" y="4730.0"/> <glyph class="state variable" id="_da269d8d-bf7d-4830-8913-1c2d9264a61c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6211.5684" y="4725.0"/> </glyph> <glyph class="unit of information" id="_6ef4706e-6030-4c0f-a5e3-2507b1e06f6f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6175.0" y="4725.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7379_sa52" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <clone/> <bbox w="80.0" h="40.0" x="5860.0" y="2780.0"/> <glyph class="state variable" id="_6b011174-5b9a-4707-977d-300cd5e64dcf"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="5861.077" y="2775.0"/> </glyph> <glyph class="state variable" id="_6a657269-d887-4caf-a0f0-74acb8b4e62a"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="5906.0845" y="2775.0"/> </glyph> <glyph class="state variable" id="_6669569b-3586-4d3a-90a7-c7874ca024a3"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="5906.3213" y="2815.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7379_sa4661" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <clone/> <bbox w="80.0" h="40.0" x="3790.0" y="6897.047"/> <glyph class="state variable" id="_1eebbb2a-6aa1-446e-b7dd-cb70e28bb9c5"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="3791.0771" y="6892.047"/> </glyph> <glyph class="state variable" id="_858db3c0-2438-43c5-a248-d8b9f7117604"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="3836.0845" y="6892.047"/> </glyph> <glyph class="state variable" id="_a3c181cb-c5c3-4d1b-b581-4ff891535d6d"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="3836.321" y="6932.047"/> </glyph> </glyph> <glyph class="macromolecule" id="s7379_sa4793" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <clone/> <bbox w="80.0" h="40.0" x="9800.0" y="5780.0"/> <glyph class="state variable" id="_43b527f0-38ce-4541-99a2-f453511c8ffa"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="9801.077" y="5775.0"/> </glyph> <glyph class="state variable" id="_332ae1c2-2ffb-4c8d-a64b-9dd0f69dbcba"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="9846.084" y="5775.0"/> </glyph> <glyph class="state variable" id="_a3380a34-9170-42da-98cf-96197791dbeb"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="9846.321" y="5815.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7380_sa54" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="7517.9907" y="4913.8784"/> <glyph class="state variable" id="_f6cdc470-099c-42dc-bee8-7fdd9d4a8a4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7569.5884" y="4908.8784"/> </glyph> </glyph> <glyph class="macromolecule" id="s7380_sa4605" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 stratifin HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:14-3-3 theta synonym:14-3-3 zeta synonym:14-3-3 epsilon for known differences between these different proteins, cf. notes for each individual reaction References_end </body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="7273.0" y="6909.0"/> <glyph class="state variable" id="_cc485979-532c-46ff-88f9-88a369633184"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7324.5977" y="6904.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7381_sa105" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 101-1 HUGO:MIR101-1 HGNC:31488 ENTREZ:406893 microRNA 101-2 HUGO:MIR101-2 HGNC:31489 ENTREZ:406894 Identifiers_end </body> </html> </notes> <label text="MIR101*"/> <clone/> <bbox w="90.0" h="25.0" x="1892.6754" y="6640.992"/> <glyph class="unit of information" id="_401873d7-e49c-42d7-ac6e-82447f25560b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="1922.6754" y="6635.992"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7381_sa4618" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 101-1 HUGO:MIR101-1 HGNC:31488 ENTREZ:406893 microRNA 101-2 HUGO:MIR101-2 HGNC:31489 ENTREZ:406894 Identifiers_end </body> </html> </notes> <label text="MIR101*"/> <clone/> <bbox w="90.0" h="25.0" x="7188.0" y="6672.5"/> <glyph class="unit of information" id="_bfac9c3a-21a0-49e9-a4bb-ea43067e71d2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7218.0" y="6667.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7382_sa1398" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 27kDa protein 1 HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: synonym:HSP27PMID:11003656 References_end </body> </html> </notes> <label text="HSPB1"/> <bbox w="80.0" h="40.0" x="6380.0" y="5660.0"/> </glyph> <glyph class="macromolecule" id="s7383_sa1406" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 heat shock 70kDa protein 1B HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 heat shock 70kDa protein 1-like HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="HSP70*"/> <clone/> <bbox w="80.0" h="40.0" x="6660.0" y="6000.0"/> </glyph> <glyph class="macromolecule" id="s7383_sa4695" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 heat shock 70kDa protein 1B HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 heat shock 70kDa protein 1-like HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="HSP70*"/> <clone/> <bbox w="80.0" h="40.0" x="2640.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s7384_sa1420" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="7140.0" y="3180.0"/> <glyph class="state variable" id="_159a6755-e32a-4489-bf79-b74d3a1481e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7158.4316" y="3175.0"/> </glyph> <glyph class="state variable" id="_4052bc32-03cf-486b-bc09-4f9b45a14191"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7181.949" y="3175.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7384_sa3950" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="7110.0" y="4100.0"/> <glyph class="state variable" id="_7dcfaab1-6c59-498f-a65e-4a2a51c3450a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7128.4316" y="4095.0"/> </glyph> <glyph class="state variable" id="_132bf299-f67c-4689-96ab-3636b6e39df2"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="7151.949" y="4095.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7384_sa3952" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:23070005 References_end </body> </html> </notes> <label text="XIAP"/> <clone/> <bbox w="80.0" h="40.0" x="6948.666" y="4537.7236"/> <glyph class="state variable" id="_c934056a-4d59-44ec-9e2d-c9de0ae584b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6967.0977" y="4532.7236"/> </glyph> <glyph class="state variable" id="_23eb8c97-0721-4aba-832f-eef591432b5d"> <state value="?" variable="S87"/> <bbox w="30.0" h="10.0" x="6990.615" y="4532.7236"/> </glyph> </glyph> <glyph class="macromolecule" id="s7385_sa1469" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:18360008 References_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="80.0" h="40.0" x="6670.0" y="2710.0"/> </glyph> <glyph class="macromolecule" id="s7385_sa4581" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:18360008 References_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="80.0" h="40.0" x="3160.0" y="6900.0"/> </glyph> <glyph class="macromolecule" id="s7385_sa4756" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock protein 90kDa beta (Grp94), member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:18360008 References_end </body> </html> </notes> <label text="HSP90B1"/> <clone/> <bbox w="80.0" h="40.0" x="9330.0" y="6840.0"/> </glyph> <glyph class="macromolecule" id="s7386_sa1496" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <clone/> <bbox w="80.0" h="40.0" x="4410.0" y="6896.87"/> </glyph> <glyph class="macromolecule" id="s7386_sa1711" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: harakiri, BCL2 interacting protein (contains only BH3 domain) HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="HRK"/> <clone/> <bbox w="80.0" h="40.0" x="4930.0" y="3590.0"/> </glyph> <glyph class="macromolecule" id="s7387_sa4569" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4788.0" y="6896.87"/> </glyph> <glyph class="nucleic acid feature" id="s7388_sa4634" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 630 HUGO:MIR630 HGNC:32886 ENTREZ:693215 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR630"/> <clone/> <bbox w="90.0" h="25.0" x="7267.0" y="6670.5"/> <glyph class="unit of information" id="_90bf5f29-26df-49b4-a925-5f246ce88e73"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7297.0" y="6665.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7388_sa4636" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 630 HUGO:MIR630 HGNC:32886 ENTREZ:693215 Identifiers_end References_begin: PMID:24272429 PMID:23665507 PMID:23377965 PMID:24206455 PMID:23453900 PMID:21145728 PMID:22902544 PMID:23550650 References_end </body> </html> </notes> <label text="MIR630"/> <clone/> <bbox w="90.0" h="25.0" x="7419.0" y="6668.5"/> <glyph class="unit of information" id="_f3ff70a9-2b2b-4ab7-b7ed-b605c1659100"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="7449.0" y="6663.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7414_sa1071" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase, 90kDa, polypeptide 1 HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase, 90kDa, polypeptide 3 HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase, 90kDa, polypeptide 2 HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:RSK1 synonym:RSK2 synonym:RSK3 References_end </body> </html> </notes> <label text="RSK*"/> <clone/> <bbox w="80.0" h="40.0" x="8685.0" y="3215.0"/> </glyph> <glyph class="macromolecule" id="s7414_sa1278" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase, 90kDa, polypeptide 1 HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase, 90kDa, polypeptide 3 HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase, 90kDa, polypeptide 2 HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:RSK1 synonym:RSK2 synonym:RSK3 References_end </body> </html> </notes> <label text="RSK*"/> <clone/> <bbox w="80.0" h="40.0" x="4950.0" y="2590.0"/> </glyph> <glyph class="macromolecule" id="s7414_sa1747" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase, 90kDa, polypeptide 1 HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase, 90kDa, polypeptide 3 HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase, 90kDa, polypeptide 2 HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION Maps_Modules_end References_begin: synonym:RSK1 synonym:RSK2 synonym:RSK3 References_end </body> </html> </notes> <label text="RSK*"/> <clone/> <bbox w="80.0" h="40.0" x="2976.25" y="2738.6084"/> </glyph> <glyph class="macromolecule" id="s7433_sa4722" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="70.0" x="8620.0" y="6795.0"/> <glyph class="state variable" id="_d512133d-ad8a-492a-8c89-1b71de380fd6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8671.568" y="6790.0"/> </glyph> <glyph class="unit of information" id="_372185ad-0adc-473b-9b4b-72b8344a0588"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8637.5" y="6790.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7434_sa4707" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 3 HUGO:EIF2AK3 hgnc_id:HGNC:3255 HGNC:3255 ENTREZ:9451 UNIPROT:Q9NZJ5 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 References_end </body> </html> </notes> <label text="PERK*"/> <bbox w="80.0" h="40.0" x="10523.906" y="4950.0"/> <glyph class="state variable" id="_52ee05d3-af30-48a8-8d5b-a1d0ba4e7eaa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10598.906" y="4973.284"/> </glyph> <glyph class="state variable" id="_b5556621-6e6e-4bf4-8cfd-6d5b5e8f90f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10598.906" y="4956.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s4_sa4750" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <bbox w="80.0" h="40.0" x="9160.0" y="6808.0"/> </glyph> <glyph class="macromolecule" id="s7436_sa4931" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="8940.0" y="5495.0"/> <glyph class="state variable" id="_e0845a23-160e-47d7-9c0c-369e5ef302a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8991.789" y="5520.0"/> </glyph> <glyph class="state variable" id="_400d3142-af10-4824-82c2-d78ed813d03a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8935.0" y="5498.7866"/> </glyph> <glyph class="state variable" id="_538aaa14-f2e3-4452-877b-129011161599"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="9049.261" y="5490.0"/> </glyph> <glyph class="unit of information" id="_327f515e-4587-460d-a08e-e7bd72a668fe"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8995.0" y="5490.0"/> </glyph> </glyph> <glyph class="phenotype" id="s7437_sa4712" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="expression of ER chaperones"/> <bbox w="300.0" h="25.0" x="10040.0" y="4138.5"/> </glyph> <glyph class="phenotype" id="s16_sa4713" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="mRNA translation"/> <bbox w="130.0" h="25.0" x="8785.0" y="6037.5"/> </glyph> <glyph class="phenotype" id="s7438_sa4714" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 References_end </body> </html> </notes> <label text="retrograde transport from ER to cytosol"/> <bbox w="260.0" h="25.0" x="10763.906" y="4677.5"/> </glyph> <glyph class="phenotype" id="s7439_sa4715" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="protein ubiquitination and destruction"/> <bbox w="280.0" h="25.0" x="9090.0" y="5977.5"/> </glyph> <glyph class="nucleic acid feature" id="s169_sa4716" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-box binding protein 1 HUGO:XBP1 hgnc_id:HGNC:12801 HGNC:12801 ENTREZ:7494 UNIPROT:P17861 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 unsliced XBP1 References_end </body> </html> </notes> <label text="uXBP1"/> <bbox w="90.0" h="25.0" x="8267.266" y="7082.5"/> <glyph class="unit of information" id="_a80e684e-0361-4e44-89ba-844d0792412b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8302.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7440_sa4717" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-box binding protein 1 HUGO:XBP1 hgnc_id:HGNC:12801 HGNC:12801 ENTREZ:7494 UNIPROT:P17861 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 References_end </body> </html> </notes> <label text="XBP1"/> <bbox w="80.0" h="40.0" x="8400.0" y="6770.0"/> </glyph> <glyph class="nucleic acid feature" id="s7441_sa4718" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-box binding protein 1 HUGO:XBP1 hgnc_id:HGNC:12801 HGNC:12801 ENTREZ:7494 UNIPROT:P17861 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 References_end </body> </html> </notes> <label text="XBP1"/> <bbox w="70.0" h="25.0" x="8277.266" y="7172.5"/> </glyph> <glyph class="nucleic acid feature" id="s7442_sa4719" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="70.0" h="25.0" x="8490.703" y="7180.5"/> </glyph> <glyph class="phenotype" id="s7443_sa4723" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 Unfolded protein response References_end </body> </html> </notes> <label text="UPR"/> <bbox w="80.0" h="30.0" x="10260.0" y="5915.0"/> </glyph> <glyph class="phenotype" id="s44_sa4724" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 ER-associated degradation References_end </body> </html> </notes> <label text="ERAD"/> <bbox w="80.0" h="30.0" x="10760.0" y="5295.0"/> </glyph> <glyph class="macromolecule" id="s163_sa4728" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase 12 HUGO:MAPK12 hgnc_id:HGNC:6874 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 HUGO:MAPK13 hgnc_id:HGNC:6875 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 HUGO:MAPK14 hgnc_id:HGNC:6876 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 mitogen-activated protein kinase 11 HUGO:MAPK11 hgnc_id:HGNC:6873 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="p38 MAPK*"/> <bbox w="80.0" h="40.0" x="9360.0" y="5450.0"/> <glyph class="state variable" id="_b9b9200d-5f8d-4145-883f-73247e8145fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9355.0" y="5456.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s276_sa4729" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase 12 HUGO:MAPK12 hgnc_id:HGNC:6874 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 HUGO:MAPK13 hgnc_id:HGNC:6875 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 HUGO:MAPK14 hgnc_id:HGNC:6876 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 mitogen-activated protein kinase 11 HUGO:MAPK11 hgnc_id:HGNC:6873 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="p38 MAPK*"/> <bbox w="80.0" h="40.0" x="9510.0" y="5450.0"/> <glyph class="state variable" id="_85ea5fdd-2fcf-43d6-8c12-085bd1640b43"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9502.5" y="5456.716"/> </glyph> </glyph> <glyph class="phenotype" id="s7444_sa4730" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:27558815 PMID:27048813 References_end </body> </html> </notes> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="10490.0" y="5455.0"/> </glyph> <glyph class="macromolecule" id="s7445_sa4732" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA damage inducible transcript 3 HUGO:DDIT3 hgnc_id:HGNC:2726 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 References_end </body> </html> </notes> <label text="CHOP*"/> <bbox w="80.0" h="40.0" x="9082.266" y="7385.0"/> <glyph class="state variable" id="_cefc2991-a47c-41a3-b9cb-d8e0b9982575"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9131.334" y="7380.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s50_sa4733" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <clone/> <bbox w="80.0" h="40.0" x="8776.5625" y="6812.5"/> <glyph class="state variable" id="_6e5c0018-f8a6-420d-a3a2-6247a2c22ad4"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="8804.095" y="6807.5"/> </glyph> <glyph class="state variable" id="_fa23ab7c-c292-49a4-9e33-21d85952efee"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="8844.0625" y="6807.715"/> </glyph> <glyph class="state variable" id="_b9377703-3e6a-47e9-8d76-c3dce5de0ff5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8828.361" y="6847.5"/> </glyph> <glyph class="state variable" id="_fed61bcc-1738-4e9d-be91-f58cadeea1ae"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="8764.555" y="6807.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s50_sa4941" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <clone/> <bbox w="80.0" h="40.0" x="9470.0" y="5690.0"/> <glyph class="state variable" id="_3943aaa2-4243-49b9-955c-d3255a747832"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="9497.532" y="5685.0"/> </glyph> <glyph class="state variable" id="_e1c80474-d5c4-4446-be58-6c3cdeaecdfb"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="9537.5" y="5685.215"/> </glyph> <glyph class="state variable" id="_797895bf-c4f6-452a-b281-263051c24292"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9521.799" y="5725.0"/> </glyph> <glyph class="state variable" id="_4b111043-7367-4086-a966-054dc67fbd30"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="9457.992" y="5685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7446_sa4734" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor receptor superfamily, member 10b HUGO:TNFRSF10B HGNC:11905 ENTREZ:8795 UNIPROT:O14763 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:20531300 Also known as DR5, TRAILR2 References_end </body> </html> </notes> <label text="TNFRSF10B"/> <bbox w="80.0" h="50.0" x="8962.4375" y="6803.0"/> <glyph class="unit of information" id="_43bb3083-955f-4d0b-9aa3-3aabf058cbee"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8979.9375" y="6798.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7449_sa4738" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor superfamily member 10b HUGO:TNFRSF10B hgnc_id:HGNC:11905 HGNC:11905 ENTREZ:8795 UNIPROT:O14763 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="TNFRSF10B"/> <bbox w="90.0" h="25.0" x="8953.141" y="7065.0"/> <glyph class="unit of information" id="_d814bab2-0ea9-4e35-945a-686f37108c6b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8988.141" y="7060.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7450_sa4739" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor superfamily member 10b HUGO:TNFRSF10B hgnc_id:HGNC:11905 HGNC:11905 ENTREZ:8795 UNIPROT:O14763 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="TNFRSF10B"/> <bbox w="70.0" h="25.0" x="8963.141" y="7165.0"/> </glyph> <glyph class="phenotype" id="s60_sa4742" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 regulated IRE1-dependent decay of mRNA References_end </body> </html> </notes> <label text="RIDD process"/> <bbox w="100.0" h="25.0" x="8797.5" y="5911.25"/> </glyph> <glyph class="phenotype" id="s7452_sa4744" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ER Stress"/> <bbox w="80.0" h="30.0" x="10463.906" y="4419.75"/> </glyph> <glyph class="macromolecule" id="s64_sa4745" compartmentRef="c39_ca41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: membrane bound transcription factor peptidase, site 1 HUGO:MBTPS1 hgnc_id:HGNC:15456 HGNC:15456 ENTREZ:8720 UNIPROT:Q14703 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="S1P*"/> <bbox w="80.0" h="40.0" x="11091.25" y="6455.0"/> </glyph> <glyph class="macromolecule" id="s7453_sa4746" compartmentRef="c39_ca41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: membrane bound transcription factor peptidase, site 2 HUGO:MBTPS2 hgnc_id:HGNC:15455 HGNC:15455 ENTREZ:51360 UNIPROT:O43462 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="S2P*"/> <bbox w="80.0" h="40.0" x="11093.75" y="6555.0"/> </glyph> <glyph class="nucleic acid feature" id="s68_sa4751" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BiP*"/> <bbox w="70.0" h="25.0" x="9160.703" y="7163.75"/> </glyph> <glyph class="nucleic acid feature" id="s69_sa4752" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BiP*"/> <bbox w="90.0" h="25.0" x="9135.0" y="7067.5"/> <glyph class="unit of information" id="_f6ed0236-e511-4f3e-921d-32b67815fd67"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9170.0" y="7062.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s71_sa4754" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA damage inducible transcript 3 HUGO:DDIT3 hgnc_id:HGNC:2726 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CHOP*"/> <bbox w="70.0" h="25.0" x="9247.266" y="7172.5"/> </glyph> <glyph class="nucleic acid feature" id="s72_sa4755" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA damage inducible transcript 3 HUGO:DDIT3 hgnc_id:HGNC:2726 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CHOP*"/> <bbox w="90.0" h="25.0" x="9237.266" y="7062.5"/> <glyph class="unit of information" id="_64ae43f1-2593-4cfb-b2d0-035fa247335e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9272.266" y="7057.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s76_sa4759" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cAMP responsive element binding protein 3 like 1 HUGO:CREB3L1 hgnc_id:HGNC:18856 HGNC:18856 ENTREZ:90993 UNIPROT:Q96BA8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:17887918 References_end </body> </html> </notes> <label text="OASIS*"/> <bbox w="80.0" h="40.0" x="10070.0" y="5900.0"/> </glyph> <glyph class="macromolecule" id="s77_sa4760" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cAMP responsive element binding protein 3 like 3 HUGO:CREB3L3 hgnc_id:HGNC:18855 HGNC:18855 ENTREZ:84699 UNIPROT:Q68CJ9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:17887918 References_end </body> </html> </notes> <label text="CREB-H*"/> <bbox w="80.0" h="40.0" x="10070.0" y="5950.0"/> </glyph> <glyph class="macromolecule" id="s79_sa4761" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cAMP responsive element binding protein 3 HUGO:CREB3 hgnc_id:HGNC:2347 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:17887918 References_end </body> </html> </notes> <label text="Luman*"/> <bbox w="80.0" h="40.0" x="10450.0" y="5860.0"/> </glyph> <glyph class="macromolecule" id="s80_sa4762" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein disulfide isomerase family A member 6 HUGO:PDIA6 hgnc_id:HGNC:30168 HGNC:30168 ENTREZ:10130 UNIPROT:Q15084 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="PDIA6"/> <bbox w="80.0" h="40.0" x="8100.0" y="6820.0"/> </glyph> <glyph class="nucleic acid feature" id="s81_sa4763" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein disulfide isomerase family A member 6 HUGO:PDIA6 hgnc_id:HGNC:30168 HGNC:30168 ENTREZ:10130 UNIPROT:Q15084 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="PDIA6"/> <bbox w="90.0" h="25.0" x="8088.203" y="7083.5"/> <glyph class="unit of information" id="_d79fdf58-93e7-42a6-a5a8-04b2d88e77d8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8123.203" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s82_sa4764" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein disulfide isomerase family A member 6 HUGO:PDIA6 hgnc_id:HGNC:30168 HGNC:30168 ENTREZ:10130 UNIPROT:Q15084 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="PDIA6"/> <bbox w="70.0" h="25.0" x="8098.203" y="7173.5"/> </glyph> <glyph class="nucleic acid feature" id="s7456_sa4765" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 455 HUGO:MIR455 hgnc_id:HGNC:32344 HGNC:32344 ENTREZ:619556 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR455"/> <bbox w="90.0" h="25.0" x="9847.266" y="7292.5"/> <glyph class="unit of information" id="_09e7056a-cf31-438e-8f0a-e392f819df58"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="9877.266" y="7287.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s85_sa4766" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 455 HUGO:MIR455 hgnc_id:HGNC:32344 HGNC:32344 ENTREZ:619556 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR455"/> <bbox w="70.0" h="25.0" x="9857.266" y="7382.5"/> </glyph> <glyph class="macromolecule" id="s89_sa4767" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit alpha HUGO:EIF2S1 hgnc_id:HGNC:3265 HGNC:3265 ENTREZ:1965 UNIPROT:P05198 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 eukaryotic translation initiation factor 2 subunit alpha PMID:12667446 PMID:16246152 PMID:12601012 References_end </body> </html> </notes> <label text="EIF2S1"/> <bbox w="80.0" h="40.0" x="9570.0" y="6430.0"/> <glyph class="state variable" id="_07a9f9e7-8225-4a2c-9611-cb6dcb78f956"> <state value="P" variable="Ser51"/> <bbox w="40.0" h="10.0" x="9606.949" y="6425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s90_sa4768" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit beta HUGO:EIF2S2 hgnc_id:HGNC:3266 HGNC:3266 ENTREZ:8894 UNIPROT:P20042 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: eukaryotic translation initiation factor 2 subunit beta PMID:23850759 References_end </body> </html> </notes> <label text="EIF2S2"/> <bbox w="80.0" h="40.0" x="9690.0" y="6490.0"/> </glyph> <glyph class="macromolecule" id="s7457_sa4769" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit alpha HUGO:EIF2S1 hgnc_id:HGNC:3265 HGNC:3265 ENTREZ:1965 UNIPROT:P05198 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 eukaryotic translation initiation factor 2 subunit alpha PMID:12667446 PMID:16246152 PMID:12601012 References_end </body> </html> </notes> <label text="EIF2S1"/> <bbox w="80.0" h="40.0" x="9730.0" y="6430.0"/> <glyph class="state variable" id="_f3649643-08e7-4e5c-9e9d-448b25d9729f"> <state value="" variable="Ser51"/> <bbox w="35.0" h="10.0" x="9769.449" y="6425.0"/> </glyph> </glyph> <glyph class="phenotype" id="s7458_sa4771" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="Translation initiation"/> <bbox w="142.5" h="26.25" x="10558.75" y="6556.875"/> </glyph> <glyph class="macromolecule" id="s7459_sa4775" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 4 HUGO:ATF4 hgnc_id:HGNC:786 HGNC:786 ENTREZ:468 UNIPROT:P18848 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF4"/> <bbox w="80.0" h="40.0" x="9850.0" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s112_sa4776" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 4 HUGO:ATF4 hgnc_id:HGNC:786 HGNC:786 ENTREZ:468 UNIPROT:P18848 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF4"/> <bbox w="70.0" h="25.0" x="9847.266" y="7183.5"/> </glyph> <glyph class="nucleic acid feature" id="s113_sa4777" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 4 HUGO:ATF4 hgnc_id:HGNC:786 HGNC:786 ENTREZ:468 UNIPROT:P18848 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF4"/> <bbox w="90.0" h="25.0" x="9837.266" y="7083.5"/> <glyph class="unit of information" id="_b68e4b01-0c4c-4e57-9a0d-9cbac0ec6be3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9872.266" y="7078.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s114_sa4778" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 1 regulatory subunit 15A HUGO:PPP1R15A hgnc_id:HGNC:14375 HGNC:14375 ENTREZ:23645 UNIPROT:O75807 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 protein phosphatase 1, regulatory (inhibitor) subunit 15A References_end </body> </html> </notes> <label text="GADD34*"/> <bbox w="80.0" h="40.0" x="9940.0" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s7460_sa4779" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 1 regulatory subunit 15A HUGO:PPP1R15A hgnc_id:HGNC:14375 HGNC:14375 ENTREZ:23645 UNIPROT:O75807 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 protein phosphatase 1, regulatory (inhibitor) subunit 15A References_end </body> </html> </notes> <label text="GADD34*"/> <bbox w="90.0" h="25.0" x="9937.266" y="7083.5"/> <glyph class="unit of information" id="_2a7a440d-f8b4-466d-a869-daea6fbe53b5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9972.266" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7461_sa4780" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein phosphatase 1 regulatory subunit 15A HUGO:PPP1R15A hgnc_id:HGNC:14375 HGNC:14375 ENTREZ:23645 UNIPROT:O75807 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 protein phosphatase 1, regulatory (inhibitor) subunit 15A References_end </body> </html> </notes> <label text="GADD34*"/> <bbox w="70.0" h="25.0" x="9947.266" y="7183.5"/> </glyph> <glyph class="nucleic acid feature" id="s117_sa4781" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 3 HUGO:ATF3 hgnc_id:HGNC:785 HGNC:785 ENTREZ:467 UNIPROT:P18847 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF3"/> <bbox w="70.0" h="25.0" x="10047.266" y="7183.5"/> </glyph> <glyph class="macromolecule" id="s7462_sa4782" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 3 HUGO:ATF3 hgnc_id:HGNC:785 HGNC:785 ENTREZ:467 UNIPROT:P18847 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF3"/> <bbox w="80.0" h="40.0" x="10040.0" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s119_sa4783" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 3 HUGO:ATF3 hgnc_id:HGNC:785 HGNC:785 ENTREZ:467 UNIPROT:P18847 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF3"/> <bbox w="90.0" h="25.0" x="10037.266" y="7083.5"/> <glyph class="unit of information" id="_00edffa0-eaa6-4324-98c3-f9657a4593ef"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10072.266" y="7078.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s120_sa2326" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <clone/> <bbox w="80.0" h="40.0" x="8690.0" y="1480.0"/> <glyph class="state variable" id="_3e87fc24-451e-45ee-bd67-b1506349d8bd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8741.568" y="1475.0"/> </glyph> <glyph class="state variable" id="_08064cb9-447d-42f6-9e1e-e28199a7869e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8708.432" y="1475.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s120_sa4784" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <clone/> <bbox w="80.0" h="40.0" x="8540.0" y="6191.0"/> <glyph class="state variable" id="_5c2f4a33-6420-441b-9ef5-ddf5ea588061"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8591.568" y="6186.0"/> </glyph> <glyph class="state variable" id="_569f3e64-cb6b-4031-ad96-5953f030dd54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8558.432" y="6186.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s120_sa5285" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <clone/> <bbox w="80.0" h="40.0" x="9530.0" y="1390.0"/> <glyph class="state variable" id="_26736bc5-acc2-4a47-8fdb-337591d5859e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9581.568" y="1385.0"/> </glyph> <glyph class="state variable" id="_1c340b60-17ef-4e51-8405-bc1a8c38edf7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9548.432" y="1385.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s121_sa4785" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <bbox w="80.0" h="40.0" x="8680.0" y="6190.0"/> <glyph class="state variable" id="_dc708c28-5004-4480-9a1f-de0d5440548b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8731.568" y="6185.0"/> </glyph> <glyph class="state variable" id="_1285360e-d205-42b2-b976-807102cab5dd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8695.932" y="6185.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s122_sa4786" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <clone/> <bbox w="80.0" h="40.0" x="8550.0" y="6110.0"/> </glyph> <glyph class="macromolecule" id="s122_sa5284" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <clone/> <bbox w="80.0" h="40.0" x="9620.0" y="1390.0"/> </glyph> <glyph class="macromolecule" id="s127_sa4789" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA damage inducible transcript 3 HUGO:DDIT3 hgnc_id:HGNC:2726 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="GADD153*"/> <bbox w="80.0" h="40.0" x="10340.0" y="6250.0"/> </glyph> <glyph class="macromolecule" id="s7463_sa4790" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum oxidoreductase 1 alpha HUGO:ERO1A hgnc_id:HGNC:13280 HGNC:13280 ENTREZ:30001 UNIPROT:Q96HE7 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ERO1A"/> <bbox w="80.0" h="40.0" x="10140.0" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s7464_sa4791" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum oxidoreductase 1 alpha HUGO:ERO1A hgnc_id:HGNC:13280 HGNC:13280 ENTREZ:30001 UNIPROT:Q96HE7 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ERO1A"/> <bbox w="70.0" h="25.0" x="10147.266" y="7183.5"/> </glyph> <glyph class="nucleic acid feature" id="s7465_sa4792" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum oxidoreductase 1 alpha HUGO:ERO1A hgnc_id:HGNC:13280 HGNC:13280 ENTREZ:30001 UNIPROT:Q96HE7 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ERO1A"/> <bbox w="90.0" h="25.0" x="10137.266" y="7083.5"/> <glyph class="unit of information" id="_ecea7df3-b1b8-478d-b36d-919dac162a6b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10172.266" y="7078.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s135_sa4794" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="9960.0" y="5780.0"/> <glyph class="state variable" id="_36ef08d7-f74c-4a62-ae08-91f1a81937c6"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="9961.077" y="5775.0"/> </glyph> <glyph class="state variable" id="_c2a0c498-5d49-4c86-abfa-ebee6f01fb86"> <state value="P" variable="S163"/> <bbox w="35.0" h="10.0" x="10003.584" y="5775.0"/> </glyph> <glyph class="state variable" id="_56be260b-dc6b-491e-a82a-0dbb6c80c14f"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10006.321" y="5815.0"/> </glyph> </glyph> <glyph class="phenotype" id="s7466_sa4795" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="Ca2+ pulse"/> <bbox w="80.0" h="30.0" x="9530.0" y="3855.0"/> </glyph> <glyph class="phenotype" id="s138_sa4796" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="Oxidative phosphorylation"/> <bbox w="160.0" h="25.0" x="10680.0" y="5407.5"/> </glyph> <glyph class="phenotype" id="s7468_sa4798" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="release of ER Ca2+"/> <bbox w="140.0" h="25.0" x="9280.0" y="3857.5"/> </glyph> <glyph class="phenotype" id="s142_sa4800" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="increase ATP levels"/> <bbox w="130.0" h="25.0" x="10695.0" y="5477.5"/> </glyph> <glyph class="phenotype" id="s143_sa4801" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="Cell survival"/> <bbox w="127.5" h="36.5625" x="10696.25" y="5561.7188"/> </glyph> <glyph class="macromolecule" id="s7470_sa4804" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="8140.0" y="5610.0"/> </glyph> <glyph class="macromolecule" id="s147_sa4805" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calreticulin HUGO:CALR hgnc_id:HGNC:1455 HGNC:1455 ENTREZ:811 UNIPROT:P27797 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CALR"/> <bbox w="80.0" h="40.0" x="8430.0" y="5350.0"/> </glyph> <glyph class="macromolecule" id="s153_sa4808" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 4 HUGO:MAP3K4 hgnc_id:HGNC:6856 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MAP3K4"/> <bbox w="80.0" h="40.0" x="8480.0" y="5760.0"/> <glyph class="state variable" id="_8020d127-5098-42cf-b2b2-fb416d7f650a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8531.568" y="5755.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7471_sa4809" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 4 HUGO:MAP3K4 hgnc_id:HGNC:6856 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MAP3K4"/> <bbox w="80.0" h="40.0" x="8620.0" y="5760.0"/> <glyph class="state variable" id="_14c565f1-f4b5-4c18-ac78-9e3e7d4d1b70"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8669.068" y="5755.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s168_sa4810" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin dependent kinase 5 HUGO:CDK5 hgnc_id:HGNC:1774 HGNC:1774 ENTREZ:1020 UNIPROT:Q00535 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CDK5"/> <clone/> <bbox w="80.0" h="40.0" x="8550.0" y="5690.0"/> </glyph> <glyph class="macromolecule" id="s168_sa4811" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cyclin dependent kinase 5 HUGO:CDK5 hgnc_id:HGNC:1774 HGNC:1774 ENTREZ:1020 UNIPROT:Q00535 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CDK5"/> <clone/> <bbox w="80.0" h="40.0" x="8400.0" y="5690.0"/> </glyph> <glyph class="phenotype" id="s159_sa4812" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:27558815 References_end </body> </html> </notes> <label text="Cell death"/> <bbox w="115.0" h="37.875" x="10472.5" y="5561.0625"/> </glyph> <glyph class="phenotype" id="s171_sa4813" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:22955944 References_end </body> </html> </notes> <label text="Reorganization of ER membranes"/> <bbox w="210.0" h="35.0" x="10875.0" y="4052.5"/> </glyph> <glyph class="macromolecule" id="s7472_sa4814" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="80.0" h="40.0" x="10710.0" y="4050.0"/> <glyph class="state variable" id="_5ee566f8-b089-4ff8-bb72-4389e9831310"> <state value="" variable=""/> <bbox w="10.0" h="10.0" 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Identifiers_begin: glutamate ionotropic receptor NMDA type subunit associated protein 1 HUGO:GRINA hgnc_id:HGNC:4589 HGNC:4589 ENTREZ:2907 UNIPROT:Q7Z429 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Binding of Bax and Bak to IRE1 is negatively regulated by Bax Inhibitor 1 (BI-1), a transmembrane protein localized to the ER and nuclear envelope References_end </body> </html> </notes> <label text="TMBIM3"/> <bbox w="80.0" h="50.0" x="10113.906" y="4945.0"/> <glyph class="state variable" id="_96bd48d6-837b-4908-942f-99b8b19276ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10165.475" y="4940.0"/> </glyph> <glyph class="unit of information" id="_faa5c4f6-3771-4b5a-b475-0c1741a4cd3f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10131.406" y="4940.0"/> </glyph> </glyph> <glyph class="phenotype" id="s199_sa4822" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="low Ca2+ level"/> <bbox w="120.0" h="35.0" x="9160.0" y="4582.5"/> </glyph> <glyph class="macromolecule" id="s200_sa4823" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="9703.906" y="4700.0"/> <glyph class="state variable" id="_f3089424-7a8a-485a-8356-9552fa2ce067"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9722.338" y="4695.0"/> </glyph> <glyph class="state variable" id="_3a46cffc-f605-492a-9690-dc82220d7952"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9752.975" y="4695.0"/> </glyph> <glyph class="state variable" id="_4bd5e496-87d8-48b6-9d1a-907bc9b8f5b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9698.906" y="4715.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7473_sa4825" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <clone/> <bbox w="80.0" h="40.0" x="10580.0" y="4810.0"/> </glyph> <glyph class="macromolecule" id="s7473_sa4959" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <clone/> <bbox w="80.0" h="40.0" x="9383.906" y="4810.0"/> </glyph> <glyph class="nucleic acid feature" id="s228_sa4826" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 30c-2 HUGO:MIR30C2 hgnc_id:HGNC:31627 HGNC:31627 ENTREZ:407032 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR30C2 "/> <bbox w="90.0" h="25.0" x="10007.266" y="7293.5"/> <glyph class="unit of information" id="_a22c69d5-30b4-4282-a403-fdee4e755fd4"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="10037.266" y="7288.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s229_sa4827" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 30c-2 HUGO:MIR30C2 hgnc_id:HGNC:31627 HGNC:31627 ENTREZ:407032 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR30C2 "/> <bbox w="70.0" h="25.0" x="10017.266" y="7383.5"/> </glyph> <glyph class="nucleic acid feature" id="s230_sa4828" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 211 HUGO:MIR211 hgnc_id:HGNC:31588 HGNC:31588 ENTREZ:406993 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR211"/> <bbox w="90.0" h="25.0" x="10087.266" y="7292.5"/> <glyph class="unit of information" id="_459152b9-6fe9-4638-8760-3f722a825e3c"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="10117.266" y="7287.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s231_sa4829" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 211 HUGO:MIR211 hgnc_id:HGNC:31588 HGNC:31588 ENTREZ:406993 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR211"/> <bbox w="70.0" h="25.0" x="10097.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s7474_sa4831" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 221 HUGO:MIR221 hgnc_id:HGNC:31601 HGNC:31601 ENTREZ:407006 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="MIR221"/> <bbox w="70.0" h="25.0" x="9937.266" y="7382.5"/> </glyph> <glyph class="macromolecule" id="s7475_sa4836" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:ASK1 References_end </body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="9420.0" y="5370.0"/> <glyph class="state variable" id="_883074c0-72ac-428a-8d65-d3cd37d43fad"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="9428.595" y="5365.0"/> </glyph> <glyph class="state variable" id="_a6c7b312-228c-4dae-9655-27e2306ba60a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9469.068" y="5365.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s254_sa4837" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cAMP responsive element binding protein 3 like 4 HUGO:CREB3L4 hgnc_id:HGNC:18854 HGNC:18854 ENTREZ:148327 UNIPROT:Q8TEY5 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:17887918 References_end </body> </html> </notes> <label text="CREB4*"/> <bbox w="80.0" h="40.0" x="10450.0" y="5910.0"/> </glyph> <glyph class="macromolecule" id="s7476_sa4838" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cAMP responsive element binding protein 3 like 2 HUGO:CREB3L2 hgnc_id:HGNC:23720 HGNC:23720 ENTREZ:64764 UNIPROT:Q70SY1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:17887918 References_end </body> </html> </notes> <label text="BBF2H7*"/> <bbox w="80.0" h="40.0" x="10450.0" y="5980.0"/> </glyph> <glyph class="nucleic acid feature" id="s7477_sa4842" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: X-box binding protein 1 HUGO:XBP1 hgnc_id:HGNC:12801 HGNC:12801 ENTREZ:7494 UNIPROT:P17861 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 sliced XBP1 PMID:23430059 IRE1a splices a 26 nucleotide intron from XBP1 mRNA causing a frame shift enabling translation and generation of a basic leucine zipper family transcription factor, spliced XBP1 (XBP1s) References_end </body> </html> </notes> <label text="sXBP1"/> <bbox w="90.0" h="25.0" x="8387.266" y="7082.5"/> <glyph class="unit of information" id="_c4e13895-a741-4f1e-a254-6ff07289486a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8422.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7478_sa4843" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor, erythroid 2 like 2 HUGO:NFE2L2 hgnc_id:HGNC:7782 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 References_end </body> </html> </notes> <label text="NRF2*"/> <bbox w="80.0" h="40.0" x="10360.0" y="5130.0"/> <glyph class="state variable" id="_33c3dc01-09dc-48e4-9b88-2407fba4cfa3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10435.0" y="5145.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7479_sa4844" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor, erythroid 2 like 2 HUGO:NFE2L2 hgnc_id:HGNC:7782 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 References_end </body> </html> </notes> <label text="NRF2*"/> <bbox w="80.0" h="40.0" x="10360.0" y="5250.0"/> <glyph class="state variable" id="_df06b33c-d662-4a68-af8e-0ec9d2d3c4cc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10432.5" y="5265.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s282_sa4845" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 2 HUGO:EIF2AK2 hgnc_id:HGNC:9437 HGNC:9437 ENTREZ:5610 UNIPROT:P19525 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:12601012 References_end </body> </html> </notes> <label text="PKR*"/> <clone/> <bbox w="80.0" h="40.0" x="9680.0" y="6290.0"/> </glyph> <glyph class="macromolecule" id="s282_sa4878" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 2 HUGO:EIF2AK2 hgnc_id:HGNC:9437 HGNC:9437 ENTREZ:5610 UNIPROT:P19525 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:12601012 References_end </body> </html> </notes> <label text="PKR*"/> <clone/> <bbox w="80.0" h="40.0" x="9680.0" y="6190.0"/> </glyph> <glyph class="phenotype" id="s283_sa4846" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 References_end </body> </html> </notes> <label text="hyperoxidation"/> <bbox w="120.0" h="35.0" x="9520.0" y="4582.5"/> </glyph> <glyph class="source and sink" id="s288_sa4851" compartmentRef="c1_ca1"> <label text="s288"/> <bbox w="30.0" h="30.0" x="9777.5" y="6731.25"/> </glyph> <glyph class="macromolecule" id="s292_sa4967" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Jun proto-oncogene, AP-1 transcription factor subunit HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 References_end </body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="9390.0" y="5550.0"/> <glyph class="state variable" id="_96c4c84d-0173-4ddb-8425-57e5819e4360"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9441.568" y="5545.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7480_sa4853" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Jun proto-oncogene, AP-1 transcription factor subunit HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 References_end </body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="8917.734" y="7311.875"/> <glyph class="state variable" id="_d6e64a03-d4cd-4844-9c1e-b9bc2b809111"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8966.803" y="7306.875"/> </glyph> </glyph> <glyph class="macromolecule" id="s299_sa4854" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: biogenesis of lysosomal organelles complex 1 subunit 1 HUGO:BLOC1S1 hgnc_id:HGNC:4200 HGNC:4200 ENTREZ:2647 UNIPROT:P78537 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: KAT2A PMID:26587781 References_end </body> </html> </notes> <label text="GCN5*"/> <bbox w="80.0" h="40.0" x="8902.266" y="7435.0"/> </glyph> <glyph class="macromolecule" id="s302_sa4855" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor superfamily member 10a HUGO:TNFRSF10A hgnc_id:HGNC:11904 HGNC:11904 ENTREZ:8797 UNIPROT:O00220 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: TNFRSF10A PMID:26587781 References_end </body> </html> </notes> <label text="DR4*"/> <bbox w="80.0" h="50.0" x="8870.0" y="6803.0"/> <glyph class="unit of information" id="_9715f254-e8b2-4da1-82dc-ef1e39fac46d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8887.5" y="6798.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7481_sa4856" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor superfamily member 10a HUGO:TNFRSF10A hgnc_id:HGNC:11904 HGNC:11904 ENTREZ:8797 UNIPROT:O00220 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: TNFRSF10A PMID:26587781 References_end </body> </html> </notes> <label text="DR4*"/> <bbox w="70.0" h="25.0" x="8867.266" y="7172.5"/> </glyph> <glyph class="nucleic acid feature" id="s7482_sa4857" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: TNF receptor superfamily member 10a HUGO:TNFRSF10A hgnc_id:HGNC:11904 HGNC:11904 ENTREZ:8797 UNIPROT:O00220 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: TNFRSF10A PMID:26587781 References_end </body> </html> </notes> <label text="DR4*"/> <bbox w="90.0" h="25.0" x="8857.266" y="7072.5"/> <glyph class="unit of information" id="_629cbce2-246f-4ae2-b875-60dfb2ea84d3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8892.266" y="7067.5"/> </glyph> </glyph> <glyph class="phenotype" id="s7483_sa4858" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:17991856 References_end </body> </html> </notes> <label text="Persistant ER Stress"/> <bbox w="170.0" h="25.0" x="10638.906" y="4417.5"/> </glyph> <glyph class="macromolecule" id="s7484_sa4859" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 HUGO:CASP8 hgnc_id:HGNC:1509 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end </body> </html> </notes> <label text="CASP8"/> <bbox w="80.0" h="40.0" x="10668.214" y="5909.2856"/> <glyph class="state variable" id="_c9809c9f-6459-402b-8259-3d595c806ebc"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10735.714" y="5916.0645"/> </glyph> </glyph> <glyph class="macromolecule" id="s310_sa4860" compartmentRef="c40_ca42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 hgnc_id:HGNC:11280 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 References_end </body> </html> </notes> <label text="SQSTM1 "/> <bbox w="80.0" h="40.0" x="11215.0" y="5670.0"/> </glyph> <glyph class="macromolecule" id="s311_sa4861" compartmentRef="c40_ca42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:15325588 PMID:23725295 LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine PMID:24070470 References_end </body> </html> </notes> <label text="LC3*"/> <bbox w="80.0" h="40.0" x="11205.0" y="5720.0"/> <glyph class="state variable" id="_bfbd73d5-5e73-4a06-9d18-a816af2b2b6a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11280.0" y="5726.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s327_sa4864" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tripartite motif containing 13 HUGO:TRIM13 hgnc_id:HGNC:9976 HGNC:9976 ENTREZ:10206 UNIPROT:O60858 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 References_end </body> </html> </notes> <label text="TRIM13"/> <bbox w="80.0" h="40.0" x="10770.0" y="5700.0"/> </glyph> <glyph class="phenotype" id="s335_sa4866" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26618107 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="high Ca2+ cytosol level"/> <bbox w="145.0" h="32.5" x="8977.5" y="3853.75"/> </glyph> <glyph class="macromolecule" id="s336_sa4867" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Jun proto-oncogene, AP-1 transcription factor subunit HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Fos proto-oncogene, AP-1 transcription factor subunit HUGO:FOS hgnc_id:HGNC:3796 HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26618107 References_end </body> </html> </notes> <label text="AP-1*"/> <bbox w="80.0" h="40.0" x="9560.0" y="5580.0"/> <glyph class="state variable" id="_1ff65c11-8ebe-43af-9932-d8b9d7eb7a3b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9635.0" y="5603.284"/> </glyph> <glyph class="state variable" id="_1a7fbfdd-197e-4089-ba45-8e5091a5cde3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9635.0" y="5586.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s597_sa4868" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Jun proto-oncogene, AP-1 transcription factor subunit HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Fos proto-oncogene, AP-1 transcription factor subunit HUGO:FOS hgnc_id:HGNC:3796 HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26618107 References_end </body> </html> </notes> <label text="AP-1*"/> <bbox w="80.0" h="40.0" x="9780.0" y="5580.0"/> <glyph class="state variable" id="_fe445179-c2e5-4f31-83a8-e4c831ba88fd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9852.5" y="5603.284"/> </glyph> <glyph class="state variable" id="_e956d26a-106f-4975-b330-8983a60becb2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9852.5" y="5586.716"/> </glyph> </glyph> <glyph class="phenotype" id="s7485_sa4870" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12667446 References_end </body> </html> </notes> <label text="reduce translation initiation"/> <bbox w="180.0" h="25.0" x="9290.0" y="6087.5"/> </glyph> <glyph class="phenotype" id="s339_sa4871" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12667446 References_end </body> </html> </notes> <label text="reduced protein synthesis"/> <bbox w="160.0" h="25.0" x="9270.0" y="6157.5"/> </glyph> <glyph class="macromolecule" id="s281_sa4872" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 4 HUGO:EIF2AK4 hgnc_id:HGNC:19687 HGNC:19687 ENTREZ:440275 UNIPROT:Q9P2K8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:12667446 GCN2 is activated by uncharged tRNAs PMID:15964839 References_end </body> </html> </notes> <label text="GCN2*"/> <bbox w="80.0" h="40.0" x="9570.0" y="6160.0"/> </glyph> <glyph class="nucleic acid feature" id="s7486_sa4873" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:15964839 GCN2 is activated by uncharged tRNAs deacetylated tRNAs References_end </body> </html> </notes> <label text="uncharged tRNAs*"/> <bbox w="145.0" h="22.5" x="9487.5" y="6088.75"/> <glyph class="unit of information" id="_f6b19308-71f4-4d21-94d9-5fe761070668"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9550.0" y="6083.75"/> </glyph> </glyph> <glyph class="phenotype" id="s342_sa4874" compartmentRef="c1_ca1"> <label text="amino acid starvation"/> <bbox w="145.0" h="22.5" x="9487.5" y="6018.75"/> </glyph> <glyph class="macromolecule" id="s343_sa4875" compartmentRef="c1_ca1"> <label text="GCN4"/> <bbox w="80.0" h="40.0" x="10240.9375" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s344_sa4876" compartmentRef="c13_ca13"> <label text="GCN4"/> <bbox w="90.0" h="25.0" x="10237.266" y="7083.5"/> <glyph class="unit of information" id="_fce1a9da-1862-4cc9-a422-ecdb00faf206"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10272.266" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s345_sa4877" compartmentRef="c13_ca13"> <label text="GCN4"/> <bbox w="70.0" h="25.0" x="10247.266" y="7172.5"/> </glyph> <glyph class="phenotype" id="s7487_sa4879" compartmentRef="c1_ca1"> <label text="presence of dsRNA"/> <bbox w="140.0" h="25.0" x="9660.0" y="6087.5"/> </glyph> <glyph class="phenotype" id="s362_sa4880" compartmentRef="c1_ca1"> <label text="Heme deficiency"/> <bbox w="150.0" h="35.0" x="9915.0" y="6232.5"/> </glyph> <glyph class="macromolecule" id="s363_sa4881" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 1 HUGO:EIF2AK1 hgnc_id:HGNC:24921 HGNC:24921 ENTREZ:27102 UNIPROT:Q9BQI3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:12601012 References_end </body> </html> </notes> <label text="HRI*"/> <clone/> <bbox w="80.0" h="40.0" x="9790.0" y="6290.0"/> </glyph> <glyph class="macromolecule" id="s363_sa4882" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 1 HUGO:EIF2AK1 hgnc_id:HGNC:24921 HGNC:24921 ENTREZ:27102 UNIPROT:Q9BQI3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:12601012 References_end </body> </html> </notes> <label text="HRI*"/> <clone/> <bbox w="80.0" h="40.0" x="9790.0" y="6190.0"/> </glyph> <glyph class="nucleic acid feature" id="s7488_sa4883" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MACC1, MET transcriptional regulator HUGO:MACC1 hgnc_id:HGNC:30215 HGNC:30215 ENTREZ:346389 UNIPROT:Q6ZN28 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12667446 References_end </body> </html> </notes> <label text="Met-tRNA*"/> <bbox w="90.0" h="25.0" x="10015.0" y="6417.5"/> <glyph class="unit of information" id="_388f69b4-05a7-4a4b-85d4-274d5adcd88f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10050.0" y="6412.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s7489_sa4929" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: Eeyarestatin I, EerI PMID:19164757 References_end </body> </html> </notes> <label text="Eeyarestatin I"/> <bbox w="80.0" h="30.0" x="11130.0" y="5375.0"/> <glyph class="unit of information" id="_10813353-659a-4b51-9d28-1c908eae0319"> <label text="drug"/> <bbox w="25.0" h="10.0" x="11157.5" y="5370.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s412_sa4888" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: bortezomib PMID:19164757 References_end </body> </html> </notes> <label text="bortezomib"/> <bbox w="80.0" h="30.0" x="10702.266" y="7390.0"/> <glyph class="unit of information" id="_1ec7c5a9-99c7-42d6-9569-5f6d79117b46"> <label text="drug"/> <bbox w="25.0" h="10.0" x="10729.766" y="7385.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s416_sa4891" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 hgnc_id:HGNC:9108 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMAIP1 PMID:26587781 PMID:19164757 References_end </body> </html> </notes> <label text="NOXA*"/> <bbox w="70.0" h="25.0" x="10507.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s417_sa4892" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 hgnc_id:HGNC:9108 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMAIP1 PMID:26587781 PMID:19164757 References_end </body> </html> </notes> <label text="NOXA*"/> <bbox w="90.0" h="25.0" x="10497.266" y="7082.5"/> <glyph class="unit of information" id="_494ddafe-67db-4c8c-828f-c44694d4c86c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10532.266" y="7077.5"/> </glyph> </glyph> <glyph class="phenotype" id="s418_sa4894" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: loss of homeostasis References_end </body> </html> </notes> <label text="accumulation of misfolded protein in ER"/> <bbox w="250.0" h="25.0" x="10375.0" y="4138.5"/> </glyph> <glyph class="macromolecule" id="s419_sa4895" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member B1 HUGO:H2AFB1 hgnc_id:HGNC:22516 HGNC:22516 ENTREZ:474382 UNIPROT:P0C5Y9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19164757 References_end </body> </html> </notes> <label text="H2AFB1"/> <bbox w="80.0" h="40.0" x="10322.266" y="7235.0"/> </glyph> <glyph class="macromolecule" id="s420_sa4896" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member B2 HUGO:H2AFB2 hgnc_id:HGNC:18298 HGNC:18298 ENTREZ:474381 UNIPROT:P0C5Z0 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19164757 References_end </body> </html> </notes> <label text="H2AFB2"/> <bbox w="80.0" h="40.0" x="10322.266" y="7285.0"/> </glyph> <glyph class="macromolecule" id="s421_sa4897" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member B3 HUGO:H2AFB3 hgnc_id:HGNC:14455 HGNC:14455 ENTREZ:83740 UNIPROT:P0C5Z0 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: H2AFB3 PMID:19164757 References_end </body> </html> </notes> <label text="H2AFB3"/> <bbox w="80.0" h="40.0" x="10322.266" y="7335.0"/> </glyph> <glyph class="macromolecule" id="s422_sa4898" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member J HUGO:H2AFJ hgnc_id:HGNC:14456 HGNC:14456 ENTREZ:55766 UNIPROT:Q9BTM1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: H2AFJ PMID:19164757 References_end </body> </html> </notes> <label text="H2AFJ"/> <bbox w="80.0" h="40.0" x="10322.266" y="7385.0"/> </glyph> <glyph class="macromolecule" id="s423_sa4899" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member V HUGO:H2AFV hgnc_id:HGNC:20664 HGNC:20664 ENTREZ:94239 UNIPROT:Q71UI9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: H2AFV PMID:19164757 References_end </body> </html> </notes> <label text="H2AFV"/> <bbox w="80.0" h="40.0" x="10412.266" y="7235.0"/> </glyph> <glyph class="macromolecule" id="s425_sa4901" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member Y HUGO:H2AFY hgnc_id:HGNC:4740 HGNC:4740 ENTREZ:9555 UNIPROT:O75367 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: H2AFY PMID:19164757 References_end </body> </html> </notes> <label text="H2AFY"/> <bbox w="80.0" h="40.0" x="10412.266" y="7335.0"/> </glyph> <glyph class="macromolecule" id="s426_sa4902" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: H2A histone family member Z HUGO:H2AFZ hgnc_id:HGNC:4741 HGNC:4741 ENTREZ:3015 UNIPROT:P0C0S5 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: H2AFZ PMID:19164757 References_end </body> </html> </notes> <label text="H2AFZ"/> <bbox w="80.0" h="40.0" x="10372.266" y="7435.0"/> </glyph> <glyph class="macromolecule" id="s7491_sa4903" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hydroxysteroid 17-beta dehydrogenase 8 HUGO:HSD17B8 hgnc_id:HGNC:3554 HGNC:3554 ENTREZ:7923 UNIPROT:Q92506 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19164757 catalytic subunit of an ubiquitin ligase complex that ubiquitinates H2A References_end </body> </html> </notes> <label text="RING2"/> <bbox w="80.0" h="40.0" x="10602.266" y="7245.0"/> </glyph> <glyph class="macromolecule" id="s428_sa4904" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: H2AFY2 PMID:19164757 References_end </body> </html> </notes> <label text="H2AFY2 "/> <bbox w="80.0" h="40.0" x="10412.266" y="7385.0"/> </glyph> <glyph class="macromolecule" id="s433_sa4907" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="11540.0" y="5025.0"/> <glyph class="state variable" id="_2521cf78-c8fa-4222-9dd7-c5ee09b61656"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11591.789" y="5050.0"/> </glyph> <glyph class="state variable" id="_0f7eeea5-9887-4561-8ffd-00faaf8af495"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11530.0" y="5028.7866"/> </glyph> <glyph class="state variable" id="_cbc8bf62-a3ef-4824-bba5-69b573f83a90"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="11649.261" y="5020.0"/> </glyph> <glyph class="unit of information" id="_d203a13e-3b85-42ba-a018-bcb111727b4a"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11595.0" y="5020.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7492_sa4910" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NPL4 homolog, ubiquitin recognition factor HUGO:NPLOC4 hgnc_id:HGNC:18261 HGNC:18261 ENTREZ:55666 UNIPROT:Q8TAT6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:16186509 References_end </body> </html> </notes> <label text="NPL4*"/> <bbox w="80.0" h="40.0" x="11140.0" y="4720.0"/> </glyph> <glyph class="macromolecule" id="s449_sa4911" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquitin recognition factor in ER associated degradation 1 HUGO:UFD1 hgnc_id:HGNC:12520 HGNC:12520 ENTREZ:7353 UNIPROT:Q92890 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:16186509 References_end </body> </html> </notes> <label text="UFD1*"/> <bbox w="80.0" h="40.0" x="11140.0" y="4670.0"/> </glyph> <glyph class="source and sink" id="s7493_sa4912" compartmentRef="c41_ca43"> <label text="s450"/> <bbox w="30.0" h="30.0" x="11675.0" y="5435.0"/> </glyph> <glyph class="macromolecule" id="s7494_sa4913" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 References_end </body> </html> </notes> <label text="Ubiquiting enzymes*"/> <bbox w="130.0" h="40.0" x="11045.0" y="4520.0"/> </glyph> <glyph class="macromolecule" id="s457_sa4915" compartmentRef="c41_ca43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ataxin 3 HUGO:ATXN3 hgnc_id:HGNC:7106 HGNC:7106 ENTREZ:4287 UNIPROT:P54252 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:18199748 References_end </body> </html> </notes> <label text="ATXN3"/> <bbox w="80.0" h="40.0" x="11400.0" y="5335.0"/> </glyph> <glyph class="macromolecule" id="s463_sa4918" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquitination factor E4B HUGO:UBE4B hgnc_id:HGNC:12500 HGNC:12500 ENTREZ:10277 UNIPROT:O95155 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 References_end </body> </html> </notes> <label text="UFD2*"/> <bbox w="80.0" h="40.0" x="11270.0" y="5150.0"/> </glyph> <glyph class="macromolecule" id="s464_sa4919" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAD23 homolog A, nucleotide excision repair protein HUGO:RAD23A hgnc_id:HGNC:9812 HGNC:9812 ENTREZ:5886 UNIPROT:P54725 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 References_end </body> </html> </notes> <label text="RAD23A"/> <bbox w="80.0" h="40.0" x="11400.0" y="4890.0"/> </glyph> <glyph class="macromolecule" id="s465_sa4920" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAD23 homolog B, nucleotide excision repair protein HUGO:RAD23B hgnc_id:HGNC:9813 HGNC:9813 ENTREZ:5887 UNIPROT:P54727 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 References_end </body> </html> </notes> <label text="RAD23B"/> <bbox w="80.0" h="40.0" x="11230.0" y="5000.0"/> </glyph> <glyph class="macromolecule" id="s7495_sa4921" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RAD23 homolog A, nucleotide excision repair protein HUGO:RAD23A hgnc_id:HGNC:9812 HGNC:9812 ENTREZ:5886 UNIPROT:P54725 RAD23 homolog B, nucleotide excision repair protein HUGO:RAD23B hgnc_id:HGNC:9813 HGNC:9813 ENTREZ:5887 UNIPROT:P54727 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 References_end </body> </html> </notes> <label text="RAD23*"/> <bbox w="80.0" h="40.0" x="11270.0" y="5090.0"/> </glyph> <glyph class="macromolecule" id="s478_sa4922" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: derlin 1 HUGO:DERL1 hgnc_id:HGNC:28454 HGNC:28454 ENTREZ:79139 UNIPROT:Q9BUN8 derlin 2 HUGO:DERL2 hgnc_id:HGNC:17943 HGNC:17943 ENTREZ:51009 UNIPROT:Q9GZP9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="Derlin*"/> <bbox w="80.0" h="40.0" x="11530.0" y="4050.0"/> </glyph> <glyph class="macromolecule" id="s479_sa4923" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: selenoprotein S HUGO:SELENOS hgnc_id:HGNC:30396 HGNC:30396 ENTREZ:55829 UNIPROT:Q9BQE4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 PMID:19509052 References_end </body> </html> </notes> <label text="VIMP"/> <bbox w="80.0" h="40.0" x="11735.0" y="4290.0"/> </glyph> <glyph class="macromolecule" id="s7496_sa5013" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: synoviolin 1 HUGO:SYVN1 hgnc_id:HGNC:20738 HGNC:20738 ENTREZ:84447 UNIPROT:Q86TM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 PMID:18360008 HRD1 References_end </body> </html> </notes> <label text="SYVN1"/> <bbox w="80.0" h="40.0" x="11140.0" y="6850.0"/> </glyph> <glyph class="macromolecule" id="s7497_sa5007" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homocysteine inducible ER protein with ubiquitin like domain 1 HUGO:HERPUD1 hgnc_id:HGNC:13744 HGNC:13744 ENTREZ:9709 UNIPROT:Q15011 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="HERP*"/> <bbox w="80.0" h="40.0" x="10960.0" y="6850.0"/> </glyph> <glyph class="macromolecule" id="s488_sa4927" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: derlin 2 HUGO:DERL2 hgnc_id:HGNC:17943 HGNC:17943 ENTREZ:51009 UNIPROT:Q9GZP9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="DRL2"/> <bbox w="80.0" h="40.0" x="11230.0" y="4050.0"/> </glyph> <glyph class="macromolecule" id="s7498_sa4928" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: derlin 1 HUGO:DERL1 hgnc_id:HGNC:28454 HGNC:28454 ENTREZ:79139 UNIPROT:Q9BUN8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="DRL1"/> <bbox w="80.0" h="40.0" x="11340.0" y="4050.0"/> </glyph> <glyph class="macromolecule" id="s497_sa4932" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="8673.906" y="4645.0"/> <glyph class="state variable" id="_d59556ee-52da-42ad-9e5f-089b5b61eef9"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="8723.195" y="4670.0"/> </glyph> <glyph class="state variable" id="_54dc5042-5413-44bb-8eae-02afe5da46ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8668.906" y="4648.7866"/> </glyph> <glyph class="state variable" id="_b393e89f-8077-4db4-8080-ce3d84ebbd07"> <state value="?" variable="disulphide bond"/> <bbox w="90.0" h="10.0" x="8780.667" y="4640.0"/> </glyph> <glyph class="unit of information" id="_4cd1851b-00d7-4eed-8fdd-acc0e35fd7da"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8728.906" y="4640.0"/> </glyph> </glyph> <glyph class="phenotype" id="s499_sa4934" compartmentRef="c36_ca38"> <label text="chaperones"/> <bbox w="80.0" h="30.0" x="8903.906" y="4515.0"/> </glyph> <glyph class="macromolecule" id="s500_sa5012" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SEL1L ERAD E3 ligase adaptor subunit HUGO:SEL1L hgnc_id:HGNC:10717 HGNC:10717 ENTREZ:6400 UNIPROT:Q9UBV2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:16186509 References_end </body> </html> </notes> <label text="SEL1L"/> <bbox w="80.0" h="40.0" x="11050.0" y="6850.0"/> </glyph> <glyph class="phenotype" id="s503_sa4936" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23430059 As hypoxia, glucose deprivation, amino-acid starvation, oxidative stress References_end </body> </html> </notes> <label text="loss of homeostasis"/> <bbox w="150.0" h="25.0" x="9755.0" y="4487.5"/> </glyph> <glyph class="phenotype" id="s504_sa4937" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="tumor microenvironments"/> <bbox w="190.0" h="25.0" x="9735.0" y="4407.5"/> </glyph> <glyph class="phenotype" id="s506_sa4938" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23430059 IRE1a signaling is attenuated in cells undergoing prolonged ER stress PMID:17991856 References_end </body> </html> </notes> <label text="adaptative response"/> <bbox w="150.0" h="25.0" x="9775.0" y="5037.5"/> </glyph> <glyph class="macromolecule" id="s511_sa4942" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="9610.0" y="5690.0"/> <glyph class="state variable" id="_f86f1ca9-9d47-4bba-a7c6-d598086a727b"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="9637.532" y="5685.0"/> </glyph> <glyph class="state variable" id="_30cc18c5-79bf-487a-b085-2840f21a3114"> <state value="P" variable="S58"/> <bbox w="30.0" h="10.0" x="9675.0" y="5685.215"/> </glyph> <glyph class="state variable" id="_a89214fa-cc52-4b17-8153-706a770a5812"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9661.799" y="5725.0"/> </glyph> <glyph class="state variable" id="_d2cf1d63-fa04-4597-803c-4bef65407cd4"> <state value="" variable="S44"/> <bbox w="25.0" h="10.0" x="9597.992" y="5685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s513_sa4944" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BID"/> <bbox w="80.0" h="40.0" x="9610.0" y="5810.0"/> <glyph class="state variable" id="_f6f22477-1b7c-41f1-9573-fa5036fb4fa5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9663.687" y="5805.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s520_sa4946" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor kappa B subunit 2 HUGO:NFKB2 hgnc_id:HGNC:7795 HGNC:7795 ENTREZ:4791 UNIPROT:Q00653 RELA proto-oncogene, NF-kB subunit HUGO:RELA hgnc_id:HGNC:9955 HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 RELB proto-oncogene, NF-kB subunit HUGO:RELB hgnc_id:HGNC:9956 HGNC:9956 ENTREZ:5971 UNIPROT:Q01201 nuclear factor kappa B subunit 1 HUGO:NFKB1 hgnc_id:HGNC:7794 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 REL proto-oncogene, NF-kB subunit HUGO:REL hgnc_id:HGNC:9954 HGNC:9954 ENTREZ:5966 UNIPROT:Q04864 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB*"/> <bbox w="80.0" h="40.0" x="9960.0" y="5410.0"/> </glyph> <glyph class="macromolecule" id="s7499_sa4949" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: REL proto-oncogene, NF-kB subunit HUGO:REL hgnc_id:HGNC:9954 HGNC:9954 ENTREZ:5966 UNIPROT:Q04864 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="REL"/> <bbox w="80.0" h="40.0" x="10090.0" y="5490.0"/> </glyph> <glyph class="macromolecule" id="s523_sa4950" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: RELB proto-oncogene, NF-kB subunit HUGO:RELB hgnc_id:HGNC:9956 HGNC:9956 ENTREZ:5971 UNIPROT:Q01201 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RELB"/> <bbox w="80.0" h="40.0" x="10090.0" y="5410.0"/> </glyph> <glyph class="macromolecule" id="s521_sa4952" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor kappa B subunit 2 HUGO:NFKB2 hgnc_id:HGNC:7795 HGNC:7795 ENTREZ:4791 UNIPROT:Q00653 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB2"/> <bbox w="80.0" h="40.0" x="9840.0" y="5410.0"/> </glyph> <glyph class="source and sink" id="s7500_sa4954" compartmentRef="c1_ca1"> <label text="s536"/> <bbox w="30.0" h="30.0" x="9735.0" y="5295.0"/> </glyph> <glyph class="nucleic acid feature" id="s7501_sa4955" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor HUGO:TNF hgnc_id:HGNC:11892 HGNC:11892 ENTREZ:7124 UNIPROT:P01375 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TNF"/> <bbox w="70.0" h="25.0" x="8187.2656" y="7172.5"/> </glyph> <glyph class="nucleic acid feature" id="s538_sa4956" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor HUGO:TNF hgnc_id:HGNC:11892 HGNC:11892 ENTREZ:7124 UNIPROT:P01375 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TNF"/> <bbox w="90.0" h="25.0" x="8177.2656" y="7082.5"/> <glyph class="unit of information" id="_fc005108-cbc1-46be-884b-6082da8e94b1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8212.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s539_sa4957" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tumor necrosis factor HUGO:TNF HGNC:11892 ENTREZ:7124 UNIPROT:P01375 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TNF"/> <bbox w="80.0" h="40.0" x="8190.0" y="6820.0"/> </glyph> <glyph class="macromolecule" id="s569_sa4960" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: bifunctional apoptosis regulator HUGO:BFAR hgnc_id:HGNC:17613 HGNC:17613 ENTREZ:51283 UNIPROT:Q9NZS9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BFAR"/> <bbox w="80.0" h="40.0" x="10173.906" y="4880.0"/> </glyph> <glyph class="macromolecule" id="s571_sa4961" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutamate ionotropic receptor NMDA type subunit associated protein 1 HUGO:GRINA hgnc_id:HGNC:4589 HGNC:4589 ENTREZ:2907 UNIPROT:Q7Z429 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Binding of Bax and Bak to IRE1 is negatively regulated by Bax Inhibitor 1 (BI-1), a transmembrane protein localized to the ER and nuclear envelope References_end </body> </html> </notes> <label text="TMBIM3"/> <bbox w="80.0" h="50.0" x="10233.906" y="4945.0"/> <glyph class="state variable" id="_e5672280-dfd1-4d1d-a02e-c2edc9e42e21"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10280.475" y="4940.0"/> </glyph> <glyph class="unit of information" id="_c5c4324a-7434-426b-940b-e569dc16ebc4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10251.406" y="4940.0"/> </glyph> </glyph> <glyph class="source and sink" id="s572_sa4962" compartmentRef="c41_ca43"> <label text="s572"/> <bbox w="30.0" h="30.0" x="11325.0" y="5355.0"/> </glyph> <glyph class="phenotype" id="s588_sa4966" compartmentRef="c1_ca1"> <label text="Protein phosphatase 2 (PP2)"/> <bbox w="190.0" h="25.0" x="9255.0" y="5757.5"/> </glyph> <glyph class="macromolecule" id="s593_sa4968" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fos proto-oncogene, AP-1 transcription factor subunit HUGO:FOS hgnc_id:HGNC:3796 HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="FOS"/> <bbox w="80.0" h="40.0" x="9390.0" y="5600.0"/> </glyph> <glyph class="nucleic acid feature" id="s594_sa4969" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tribbles pseudokinase 3 HUGO:TRIB3 hgnc_id:HGNC:16228 HGNC:16228 ENTREZ:57761 UNIPROT:Q96RU7 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TRIB3"/> <bbox w="70.0" h="25.0" x="9647.266" y="7172.5"/> </glyph> <glyph class="nucleic acid feature" id="s595_sa4970" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tribbles pseudokinase 3 HUGO:TRIB3 hgnc_id:HGNC:16228 HGNC:16228 ENTREZ:57761 UNIPROT:Q96RU7 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TRIB3"/> <bbox w="90.0" h="25.0" x="9637.266" y="7083.5"/> <glyph class="unit of information" id="_0d8c1de9-63ce-4fa3-b871-17a034532487"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9672.266" y="7078.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s596_sa4971" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: tribbles pseudokinase 3 HUGO:TRIB3 hgnc_id:HGNC:16228 HGNC:16228 ENTREZ:57761 UNIPROT:Q96RU7 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="TRIB3"/> <bbox w="80.0" h="40.0" x="9650.9375" y="6840.0"/> </glyph> <glyph class="macromolecule" id="s601_sa4975" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 HUGO:ATP2A1 hgnc_id:HGNC:811 HGNC:811 ENTREZ:487 UNIPROT:O14983 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="ATP2A1"/> <bbox w="80.0" h="40.0" x="10116.094" y="4040.0"/> </glyph> <glyph class="macromolecule" id="s603_sa4977" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 HUGO:ATP2A3 hgnc_id:HGNC:813 HGNC:813 ENTREZ:489 UNIPROT:Q93084 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="ATP2A3"/> <bbox w="80.0" h="40.0" x="10326.094" y="4040.0"/> </glyph> <glyph class="macromolecule" id="s604_sa4978" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:28747251 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 HUGO:ATP2A1 hgnc_id:HGNC:811 HGNC:811 ENTREZ:487 UNIPROT:O14983 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 HUGO:ATP2A2 hgnc_id:HGNC:812 HGNC:812 ENTREZ:488 UNIPROT:P16615 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 HUGO:ATP2A3 hgnc_id:HGNC:813 HGNC:813 ENTREZ:489 UNIPROT:Q93084 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="SERCA*"/> <bbox w="80.0" h="40.0" x="10216.094" y="3970.0"/> </glyph> <glyph class="macromolecule" id="s605_sa4979" compartmentRef="c36_ca38"> <label text="Ryanodine receptor*"/> <bbox w="80.0" h="40.0" x="9116.094" y="4040.0"/> <glyph class="unit of information" id="_4b2d3f78-8f3a-44e8-a0d9-016866c22877"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9133.594" y="4035.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s606_sa4980" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ryanodine receptor 1 HUGO:RYR1 hgnc_id:HGNC:10483 HGNC:10483 ENTREZ:6261 UNIPROT:P21817 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RYR1"/> <bbox w="80.0" h="40.0" x="9026.094" y="4120.0"/> <glyph class="unit of information" id="_a71de854-d273-4f1f-9e74-439393b40d6d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9043.594" y="4115.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s607_sa4981" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ryanodine receptor 2 HUGO:RYR2 hgnc_id:HGNC:10484 HGNC:10484 ENTREZ:6262 UNIPROT:Q92736 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RYR2"/> <bbox w="80.0" h="40.0" x="9116.094" y="4120.0"/> <glyph class="unit of information" id="_6ee54b36-7181-43b6-ab75-c65ded7d02f1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9133.594" y="4115.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s608_sa4982" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ryanodine receptor 3 HUGO:RYR3 hgnc_id:HGNC:10485 HGNC:10485 ENTREZ:6263 UNIPROT:Q15413 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="RYR3"/> <bbox w="80.0" h="40.0" x="9216.094" y="4120.0"/> <glyph class="unit of information" id="_713d624d-1ed9-4fc9-abad-21bc8ddaf683"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9233.594" y="4115.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s609_sa4983" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peptidyl arginine deiminase 1 HUGO:PADI1 hgnc_id:HGNC:18367 HGNC:18367 ENTREZ:29943 UNIPROT:Q9ULC6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Protein Disulphide Isomerase References_end </body> </html> </notes> <label text="PDI*"/> <bbox w="80.0" h="40.0" x="9450.9375" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s610_sa4984" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peptidyl arginine deiminase 1 HUGO:PADI1 hgnc_id:HGNC:18367 HGNC:18367 ENTREZ:29943 UNIPROT:Q9ULC6 Identifiers_end </body> </html> </notes> <label text="PDI*"/> <bbox w="70.0" h="25.0" x="9445.0" y="7167.5"/> </glyph> <glyph class="nucleic acid feature" id="s611_sa4985" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peptidyl arginine deiminase 1 HUGO:PADI1 hgnc_id:HGNC:18367 HGNC:18367 ENTREZ:29943 UNIPROT:Q9ULC6 Identifiers_end </body> </html> </notes> <label text="PDI*"/> <bbox w="90.0" h="25.0" x="9437.266" y="7083.5"/> <glyph class="unit of information" id="_a4af507b-172f-4ce2-a5b3-586e653a589e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9472.266" y="7078.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s612_sa4986" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ER degradation enhancing alpha-mannosidase like protein 1 HUGO:EDEM1 hgnc_id:HGNC:18967 HGNC:18967 ENTREZ:9695 UNIPROT:Q92611 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:18360008 ERAD components References_end </body> </html> </notes> <label text="EDEM1"/> <bbox w="80.0" h="40.0" x="9560.9375" y="6840.0"/> </glyph> <glyph class="nucleic acid feature" id="s613_sa4987" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ER degradation enhancing alpha-mannosidase like protein 1 HUGO:EDEM1 hgnc_id:HGNC:18967 HGNC:18967 ENTREZ:9695 UNIPROT:Q92611 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:18360008 ERAD components References_end </body> </html> </notes> <label text="EDEM1"/> <bbox w="90.0" h="25.0" x="9547.266" y="7083.5"/> <glyph class="unit of information" id="_54e068b8-d350-4c6e-90a3-c77fcd95972b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9582.266" y="7078.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s614_sa4988" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ER degradation enhancing alpha-mannosidase like protein 1 HUGO:EDEM1 hgnc_id:HGNC:18967 HGNC:18967 ENTREZ:9695 UNIPROT:Q92611 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:18360008 ERAD components References_end </body> </html> </notes> <label text="EDEM1"/> <bbox w="70.0" h="25.0" x="9557.266" y="7162.5"/> </glyph> <glyph class="phenotype" id="s615_sa4990" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: "mitochondria associated ER membranes" arecontact sites between the ER and mitochondria with high calcium concentrations enabling mitochondrial calcium uptake References_end </body> </html> </notes> <label text="MAM"/> <bbox w="80.0" h="30.0" x="8660.0" y="4945.0"/> </glyph> <glyph class="macromolecule" id="s627_sa4991" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 9 HUGO:HSPA9 hgnc_id:HGNC:5244 HGNC:5244 ENTREZ:3313 UNIPROT:P38646 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="Grp75*"/> <bbox w="80.0" h="40.0" x="8430.0" y="4790.0"/> </glyph> <glyph class="macromolecule" id="s628_sa4992" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DnaJ heat shock protein family (Hsp40) member C3 HUGO:DNAJC3 hgnc_id:HGNC:9439 HGNC:9439 ENTREZ:5611 UNIPROT:Q13217 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 PMID:12601012 Overexpression of P58IPK inhibited eIF2 phosphorylation and reduced ATF4 and Gadd153 protein accumulation References_end </body> </html> </notes> <label text="p58IPK*"/> <bbox w="80.0" h="40.0" x="10420.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s629_sa4993" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DnaJ heat shock protein family (Hsp40) member C3 HUGO:DNAJC3 hgnc_id:HGNC:9439 HGNC:9439 ENTREZ:5611 UNIPROT:Q13217 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="p58IPK*"/> <bbox w="70.0" h="25.0" x="10417.266" y="7162.5"/> </glyph> <glyph class="nucleic acid feature" id="s630_sa4994" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DnaJ heat shock protein family (Hsp40) member C3 HUGO:DNAJC3 hgnc_id:HGNC:9439 HGNC:9439 ENTREZ:5611 UNIPROT:Q13217 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="p58IPK*"/> <bbox w="90.0" h="25.0" x="10407.266" y="7082.5"/> <glyph class="unit of information" id="_115feeb7-5634-43da-a96e-67390f928e21"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10442.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s631_sa4995" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia up-regulated 1 HUGO:HYOU1 hgnc_id:HGNC:16931 HGNC:16931 ENTREZ:10525 UNIPROT:Q9Y4L1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="GRP170*"/> <bbox w="80.0" h="40.0" x="10600.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s632_sa4996" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia up-regulated 1 HUGO:HYOU1 hgnc_id:HGNC:16931 HGNC:16931 ENTREZ:10525 UNIPROT:Q9Y4L1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="GRP170*"/> <bbox w="70.0" h="25.0" x="10597.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s633_sa4997" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hypoxia up-regulated 1 HUGO:HYOU1 hgnc_id:HGNC:16931 HGNC:16931 ENTREZ:10525 UNIPROT:Q9Y4L1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="GRP170*"/> <bbox w="90.0" h="25.0" x="10587.266" y="7082.5"/> <glyph class="unit of information" id="_355151a0-db35-44cd-b43c-24611f74f6cc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10622.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s634_sa4998" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein disulfide isomerase family A member 4 HUGO:PDIA4 hgnc_id:HGNC:30167 HGNC:30167 ENTREZ:9601 UNIPROT:P13667 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 ERP72 References_end </body> </html> </notes> <label text="PDIA4"/> <bbox w="80.0" h="40.0" x="10690.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s635_sa4999" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein disulfide isomerase family A member 4 HUGO:PDIA4 hgnc_id:HGNC:30167 HGNC:30167 ENTREZ:9601 UNIPROT:P13667 Identifiers_end </body> </html> </notes> <label text="PDIA4"/> <bbox w="90.0" h="25.0" x="10677.266" y="7082.5"/> <glyph class="unit of information" id="_6f4e9d3f-db82-485b-887d-c5b16775d052"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10712.266" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s636_sa5000" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein disulfide isomerase family A member 4 HUGO:PDIA4 hgnc_id:HGNC:30167 HGNC:30167 ENTREZ:9601 UNIPROT:P13667 Identifiers_end </body> </html> </notes> <label text="PDIA4"/> <bbox w="70.0" h="25.0" x="10687.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s637_sa5001" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DnaJ heat shock protein family (Hsp40) member B11 HUGO:DNAJB11 hgnc_id:HGNC:14889 HGNC:14889 ENTREZ:51726 UNIPROT:Q9UBS4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 ERdj3 References_end </body> </html> </notes> <label text="DNAJB11"/> <bbox w="70.0" h="25.0" x="10777.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s638_sa5002" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DnaJ heat shock protein family (Hsp40) member B11 HUGO:DNAJB11 hgnc_id:HGNC:14889 HGNC:14889 ENTREZ:51726 UNIPROT:Q9UBS4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 ERdj3 References_end </body> </html> </notes> <label text="DNAJB11"/> <bbox w="90.0" h="25.0" x="10767.266" y="7082.5"/> <glyph class="unit of information" id="_befc99c3-b3e2-4688-ae0b-912342bf3226"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10802.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s639_sa5003" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DnaJ heat shock protein family (Hsp40) member B11 HUGO:DNAJB11 hgnc_id:HGNC:14889 HGNC:14889 ENTREZ:51726 UNIPROT:Q9UBS4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 ERdj3 References_end </body> </html> </notes> <label text="DNAJB11"/> <bbox w="80.0" h="40.0" x="10780.0" y="6850.0"/> </glyph> <glyph class="macromolecule" id="s640_sa5004" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: derlin 3 HUGO:DERL3 hgnc_id:HGNC:14236 HGNC:14236 ENTREZ:91319 UNIPROT:Q96Q80 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 Derlin 3 References_end </body> </html> </notes> <label text="DERL3"/> <bbox w="80.0" h="40.0" x="10870.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s641_sa5005" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: derlin 3 HUGO:DERL3 hgnc_id:HGNC:14236 HGNC:14236 ENTREZ:91319 UNIPROT:Q96Q80 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 Derlin 3 References_end </body> </html> </notes> <label text="DERL3"/> <bbox w="70.0" h="25.0" x="10867.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s642_sa5006" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: derlin 3 HUGO:DERL3 hgnc_id:HGNC:14236 HGNC:14236 ENTREZ:91319 UNIPROT:Q96Q80 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 Derlin 3 References_end </body> </html> </notes> <label text="DERL3"/> <bbox w="90.0" h="25.0" x="10857.266" y="7082.5"/> <glyph class="unit of information" id="_ecc74d4a-643c-42f5-85cb-4e2d67c3b4f2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10892.266" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s644_sa5008" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homocysteine inducible ER protein with ubiquitin like domain 1 HUGO:HERPUD1 hgnc_id:HGNC:13744 HGNC:13744 ENTREZ:9709 UNIPROT:Q15011 Identifiers_end </body> </html> </notes> <label text="HERP*"/> <bbox w="70.0" h="25.0" x="10957.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s645_sa5009" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homocysteine inducible ER protein with ubiquitin like domain 1 HUGO:HERPUD1 hgnc_id:HGNC:13744 HGNC:13744 ENTREZ:9709 UNIPROT:Q15011 Identifiers_end </body> </html> </notes> <label text="HERP*"/> <bbox w="90.0" h="25.0" x="10947.266" y="7082.5"/> <glyph class="unit of information" id="_cbd4fd92-d512-40c6-a86b-7e3ddd4e0da7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10982.266" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7506_sa5010" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SEL1L ERAD E3 ligase adaptor subunit HUGO:SEL1L hgnc_id:HGNC:10717 HGNC:10717 ENTREZ:6400 UNIPROT:Q9UBV2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="SEL1L"/> <bbox w="70.0" h="25.0" x="11047.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s647_sa5011" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SEL1L ERAD E3 ligase adaptor subunit HUGO:SEL1L hgnc_id:HGNC:10717 HGNC:10717 ENTREZ:6400 UNIPROT:Q9UBV2 Identifiers_end </body> </html> </notes> <label text="SEL1L"/> <bbox w="90.0" h="25.0" x="11037.266" y="7082.5"/> <glyph class="unit of information" id="_a9d6981b-9024-4961-9a70-b24cc28ea410"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11072.266" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s650_sa5014" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: SYVN1 PMID:18360008 References_end </body> </html> </notes> <label text="SYNV1"/> <bbox w="70.0" h="25.0" x="11137.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s7507_sa5015" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: synoviolin 1 HUGO:SYVN1 hgnc_id:HGNC:20738 HGNC:20738 ENTREZ:84447 UNIPROT:Q86TM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="SYVN1"/> <bbox w="90.0" h="25.0" x="11127.266" y="7082.5"/> <glyph class="unit of information" id="_68abcc7e-5a82-494e-a43f-5d8200491453"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11162.266" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7508_sa5016" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: stromal cell derived factor 2 like 1 HUGO:SDF2L1 hgnc_id:HGNC:10676 HGNC:10676 ENTREZ:23753 UNIPROT:Q9HCN8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="SDF2L1"/> <bbox w="70.0" h="25.0" x="11227.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s7509_sa5017" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: stromal cell derived factor 2 like 1 HUGO:SDF2L1 hgnc_id:HGNC:10676 HGNC:10676 ENTREZ:23753 UNIPROT:Q9HCN8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="SDF2L1"/> <bbox w="90.0" h="25.0" x="11217.266" y="7082.5"/> <glyph class="unit of information" id="_0f2cb1a1-fa42-4930-b0c9-7a29930913a6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11252.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7510_sa5018" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: stromal cell derived factor 2 like 1 HUGO:SDF2L1 hgnc_id:HGNC:10676 HGNC:10676 ENTREZ:23753 UNIPROT:Q9HCN8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: SDF2L1 PMID:18360008 References_end </body> </html> </notes> <label text="SDF2L1"/> <bbox w="80.0" h="40.0" x="11230.0" y="6850.0"/> </glyph> <glyph class="macromolecule" id="s7511_sa5019" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cysteine rich with EGF like domains 2 HUGO:CRELD2 hgnc_id:HGNC:28150 HGNC:28150 ENTREZ:79174 UNIPROT:Q6UXH1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CRELD2"/> <bbox w="80.0" h="40.0" x="11320.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s7512_sa5020" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cysteine rich with EGF like domains 2 HUGO:CRELD2 hgnc_id:HGNC:28150 HGNC:28150 ENTREZ:79174 UNIPROT:Q6UXH1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CRELD2"/> <bbox w="90.0" h="25.0" x="11307.266" y="7082.5"/> <glyph class="unit of information" id="_53708cb4-056a-4e01-a0b5-b53c4c6c16c3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11342.266" y="7077.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s657_sa5021" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cysteine rich with EGF like domains 2 HUGO:CRELD2 hgnc_id:HGNC:28150 HGNC:28150 ENTREZ:79174 UNIPROT:Q6UXH1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CRELD2"/> <bbox w="70.0" h="25.0" x="11317.266" y="7152.5"/> </glyph> <glyph class="macromolecule" id="s658_sa5022" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mesencephalic astrocyte derived neurotrophic factor HUGO:MANF hgnc_id:HGNC:15461 HGNC:15461 ENTREZ:7873 UNIPROT:P55145 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="MANF"/> <bbox w="80.0" h="40.0" x="11410.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s659_sa5023" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mesencephalic astrocyte derived neurotrophic factor HUGO:MANF hgnc_id:HGNC:15461 HGNC:15461 ENTREZ:7873 UNIPROT:P55145 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="MANF"/> <bbox w="70.0" h="25.0" x="11407.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s7513_sa5024" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mesencephalic astrocyte derived neurotrophic factor HUGO:MANF hgnc_id:HGNC:15461 HGNC:15461 ENTREZ:7873 UNIPROT:P55145 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="MANF"/> <bbox w="90.0" h="25.0" x="11397.266" y="7082.5"/> <glyph class="unit of information" id="_0a0e8106-09ff-4ac1-8f48-b463a714a706"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11432.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7514_sa5025" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol glycan anchor biosynthesis class A HUGO:PIGA hgnc_id:HGNC:8957 HGNC:8957 ENTREZ:5277 UNIPROT:P37287 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="PIGA"/> <bbox w="80.0" h="40.0" x="11500.0" y="6850.0"/> </glyph> <glyph class="nucleic acid feature" id="s7515_sa5026" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol glycan anchor biosynthesis class A HUGO:PIGA hgnc_id:HGNC:8957 HGNC:8957 ENTREZ:5277 UNIPROT:P37287 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="PIGA"/> <bbox w="70.0" h="25.0" x="11497.266" y="7152.5"/> </glyph> <glyph class="nucleic acid feature" id="s663_sa5027" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphatidylinositol glycan anchor biosynthesis class A HUGO:PIGA hgnc_id:HGNC:8957 HGNC:8957 ENTREZ:5277 UNIPROT:P37287 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="PIGA"/> <bbox w="90.0" h="25.0" x="11487.266" y="7082.5"/> <glyph class="unit of information" id="_a8b3ff68-8dc4-46cb-b053-dcc7526d2c85"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11522.266" y="7077.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s665_sa5028" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 HUGO:ATP2A2 hgnc_id:HGNC:812 HGNC:812 ENTREZ:488 UNIPROT:P16615 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:18360008 PMID:28747251 SERCA2 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="ATP2A2"/> <bbox w="80.0" h="40.0" x="10910.0" y="6750.0"/> </glyph> <glyph class="nucleic acid feature" id="s666_sa5029" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 HUGO:ATP2A2 hgnc_id:HGNC:812 HGNC:812 ENTREZ:488 UNIPROT:P16615 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="ATP2A2"/> <bbox w="90.0" h="25.0" x="10897.266" y="7312.5"/> <glyph class="unit of information" id="_ea035469-81b0-4bf0-8f9a-6e0ef78f83a0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="10932.266" y="7307.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s667_sa5030" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 HUGO:ATP2A2 hgnc_id:HGNC:812 HGNC:812 ENTREZ:488 UNIPROT:P16615 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 PMID:27157108 References_end </body> </html> </notes> <label text="ATP2A2"/> <bbox w="70.0" h="25.0" x="10907.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s668_sa5031" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ORMDL sphingolipid biosynthesis regulator 2 HUGO:ORMDL2 hgnc_id:HGNC:16037 HGNC:16037 ENTREZ:29095 UNIPROT:Q53FV1 Identifiers_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="ORMDL2"/> <bbox w="70.0" h="25.0" x="10997.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s669_sa5032" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ORMDL sphingolipid biosynthesis regulator 2 HUGO:ORMDL2 hgnc_id:HGNC:16037 HGNC:16037 ENTREZ:29095 UNIPROT:Q53FV1 Identifiers_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="ORMDL2"/> <bbox w="90.0" h="25.0" x="10987.266" y="7312.5"/> <glyph class="unit of information" id="_d7579ba0-2b42-40df-9507-46a9f72c3808"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11022.266" y="7307.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s670_sa5033" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ORMDL sphingolipid biosynthesis regulator 2 HUGO:ORMDL2 hgnc_id:HGNC:16037 HGNC:16037 ENTREZ:29095 UNIPROT:Q53FV1 Identifiers_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="ORMDL2"/> <bbox w="80.0" h="40.0" x="11000.0" y="6750.0"/> </glyph> <glyph class="macromolecule" id="s672_sa5034" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: polypeptide N-acetylgalactosaminyltransferase 3 HUGO:GALNT3 hgnc_id:HGNC:4125 HGNC:4125 ENTREZ:2591 UNIPROT:Q14435 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="GALNT3"/> <bbox w="80.0" h="40.0" x="11090.0" y="6750.0"/> </glyph> <glyph class="nucleic acid feature" id="s673_sa5035" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: polypeptide N-acetylgalactosaminyltransferase 3 HUGO:GALNT3 hgnc_id:HGNC:4125 HGNC:4125 ENTREZ:2591 UNIPROT:Q14435 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="GALNT3"/> <bbox w="70.0" h="25.0" x="11087.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s674_sa5036" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: polypeptide N-acetylgalactosaminyltransferase 3 HUGO:GALNT3 hgnc_id:HGNC:4125 HGNC:4125 ENTREZ:2591 UNIPROT:Q14435 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="GALNT3"/> <bbox w="90.0" h="25.0" x="11077.266" y="7312.5"/> <glyph class="unit of information" id="_652a90f3-cae9-4975-bade-7c38f36f404c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11112.266" y="7307.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s676_sa5037" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homeobox A1 HUGO:HOXA1 hgnc_id:HGNC:5099 HGNC:5099 ENTREZ:3198 UNIPROT:P49639 Identifiers_end </body> </html> </notes> <label text="HOXA1"/> <bbox w="70.0" h="25.0" x="11177.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s677_sa5038" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homeobox A1 HUGO:HOXA1 hgnc_id:HGNC:5099 HGNC:5099 ENTREZ:3198 UNIPROT:P49639 Identifiers_end </body> </html> </notes> <label text="HOXA1"/> <bbox w="90.0" h="25.0" x="11167.266" y="7312.5"/> <glyph class="unit of information" id="_e2522604-0926-40ee-8344-f6757e04a25f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11202.266" y="7307.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s678_sa5039" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homeobox A1 HUGO:HOXA1 hgnc_id:HGNC:5099 HGNC:5099 ENTREZ:3198 UNIPROT:P49639 Identifiers_end </body> </html> </notes> <label text="HOXA1"/> <bbox w="80.0" h="40.0" x="11180.0" y="6750.0"/> </glyph> <glyph class="macromolecule" id="s679_sa5040" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: fatty acyl-CoA reductase 1 HUGO:FAR1 hgnc_id:HGNC:26222 HGNC:26222 ENTREZ:84188 UNIPROT:Q8WVX9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 MLSTD2 References_end </body> </html> </notes> <label text="FAR1"/> <bbox w="80.0" h="40.0" x="11270.0" y="6750.0"/> </glyph> <glyph class="nucleic acid feature" id="s680_sa5041" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: fatty acyl-CoA reductase 1 HUGO:FAR1 hgnc_id:HGNC:26222 HGNC:26222 ENTREZ:84188 UNIPROT:Q8WVX9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 MLSTD2 References_end </body> </html> </notes> <label text="FAR1 "/> <bbox w="70.0" h="25.0" x="11267.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s681_sa5042" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: fatty acyl-CoA reductase 1 HUGO:FAR1 hgnc_id:HGNC:26222 HGNC:26222 ENTREZ:84188 UNIPROT:Q8WVX9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 MLSTD2 References_end </body> </html> </notes> <label text="FAR1"/> <bbox w="90.0" h="25.0" x="11257.266" y="7312.5"/> <glyph class="unit of information" id="_541799a5-d216-4747-bad8-ca32695f3575"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11292.266" y="7307.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s682_sa5043" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nucleobindin 2 HUGO:NUCB2 hgnc_id:HGNC:8044 HGNC:8044 ENTREZ:4925 UNIPROT:P80303 Identifiers_end </body> </html> </notes> <label text="NUCB2"/> <bbox w="80.0" h="40.0" x="11360.0" y="6750.0"/> </glyph> <glyph class="nucleic acid feature" id="s683_sa5044" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nucleobindin 2 HUGO:NUCB2 hgnc_id:HGNC:8044 HGNC:8044 ENTREZ:4925 UNIPROT:P80303 Identifiers_end </body> </html> </notes> <label text="NUCB2"/> <bbox w="70.0" h="25.0" x="11357.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s684_sa5045" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nucleobindin 2 HUGO:NUCB2 hgnc_id:HGNC:8044 HGNC:8044 ENTREZ:4925 UNIPROT:P80303 Identifiers_end </body> </html> </notes> <label text="NUCB2"/> <bbox w="90.0" h="25.0" x="11347.266" y="7312.5"/> <glyph class="unit of information" id="_472c22ba-0337-4dfa-9241-d1c9461f8817"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11382.266" y="7307.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s685_sa5046" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calmodulin 1 HUGO:CALM1 hgnc_id:HGNC:1442 HGNC:1442 ENTREZ:801 UNIPROT:P0DP23 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CALM1"/> <bbox w="80.0" h="40.0" x="11450.0" y="6750.0"/> </glyph> <glyph class="nucleic acid feature" id="s686_sa5047" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calmodulin 1 HUGO:CALM1 hgnc_id:HGNC:1442 HGNC:1442 ENTREZ:801 UNIPROT:P0DP23 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CALM1"/> <bbox w="70.0" h="25.0" x="11447.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s687_sa5048" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calmodulin 1 HUGO:CALM1 hgnc_id:HGNC:1442 HGNC:1442 ENTREZ:801 UNIPROT:P0DP23 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CALM1"/> <bbox w="90.0" h="25.0" x="11437.266" y="7312.5"/> <glyph class="unit of information" id="_dd5ae3af-f4be-47ac-ac26-5135d1d6ecf2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11472.266" y="7307.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s688_sa5049" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: carcinoembryonic antigen related cell adhesion molecule 20 HUGO:CEACAM20 hgnc_id:HGNC:24879 HGNC:24879 ENTREZ:125931 UNIPROT:Q6UY09 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CEACAM20"/> <bbox w="70.0" h="25.0" x="11537.266" y="7382.5"/> </glyph> <glyph class="nucleic acid feature" id="s689_sa5050" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: carcinoembryonic antigen related cell adhesion molecule 20 HUGO:CEACAM20 hgnc_id:HGNC:24879 HGNC:24879 ENTREZ:125931 UNIPROT:Q6UY09 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CEACAM20"/> <bbox w="90.0" h="25.0" x="11527.266" y="7312.5"/> <glyph class="unit of information" id="_ae90d797-fc95-44bc-93fc-15fa95bcb883"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11562.266" y="7307.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s690_sa5051" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: carcinoembryonic antigen related cell adhesion molecule 20 HUGO:CEACAM20 hgnc_id:HGNC:24879 HGNC:24879 ENTREZ:125931 UNIPROT:Q6UY09 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 References_end </body> </html> </notes> <label text="CEACAM20"/> <bbox w="80.0" h="40.0" x="11540.0" y="6750.0"/> </glyph> <glyph class="phenotype" id="s691_sa5052" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18360008 PMID:12601012 References_end </body> </html> </notes> <label text="viral infection"/> <bbox w="100.0" h="25.0" x="9680.0" y="5997.5"/> </glyph> <glyph class="macromolecule" id="s692_sa5053" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 1 HUGO:ITPR1 hgnc_id:HGNC:6180 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 inositol 1,4,5-trisphosphate receptor type 1 References_end </body> </html> </notes> <label text="ITPR1 "/> <bbox w="80.0" h="40.0" x="8810.0" y="4410.0"/> <glyph class="unit of information" id="_28bb0c8d-ba02-4998-a79c-e06623ceaaa7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8827.5" y="4405.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s693_sa5054" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 2 HUGO:ITPR2 hgnc_id:HGNC:6181 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 inositol 1,4,5-trisphosphate receptor type 2 References_end </body> </html> </notes> <label text="ITPR2"/> <bbox w="80.0" h="40.0" x="8900.0" y="4410.0"/> <glyph class="unit of information" id="_2630af01-3996-4ead-a73d-800fcf7818c3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8917.5" y="4405.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s694_sa5055" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 3 HUGO:ITPR3 hgnc_id:HGNC:6182 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18360008 inositol 1,4,5-trisphosphate receptor type 3 References_end </body> </html> </notes> <label text="ITPR3"/> <bbox w="80.0" h="40.0" x="8990.0" y="4410.0"/> <glyph class="unit of information" id="_046c6dba-1a81-4b9a-85d3-e7da771ba160"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9007.5" y="4405.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s703_sa5058" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 1 References_end </body> </html> </notes> <label text="VDAC1"/> <bbox w="80.0" h="40.0" x="8170.0" y="5240.0"/> </glyph> <glyph class="macromolecule" id="s704_sa5059" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 2 References_end </body> </html> </notes> <label text="VDAC2"/> <bbox w="80.0" h="40.0" x="8170.0" y="5320.0"/> </glyph> <glyph class="macromolecule" id="s7517_sa5060" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Voltage-dependent anion-selective channel protein 3 References_end </body> </html> </notes> <label text="VDAC3"/> <bbox w="80.0" h="40.0" x="8300.0" y="5320.0"/> </glyph> <glyph class="macromolecule" id="s7518_sa5062" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 4 HUGO:CASP4 hgnc_id:HGNC:1505 HGNC:1505 ENTREZ:837 UNIPROT:P49662 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="Caspase4*"/> <clone/> <bbox w="80.0" h="40.0" x="8460.0" y="3860.0"/> </glyph> <glyph class="macromolecule" id="s7518_sa5386" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 4 HUGO:CASP4 hgnc_id:HGNC:1505 HGNC:1505 ENTREZ:837 UNIPROT:P49662 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 References_end </body> </html> </notes> <label text="Caspase4*"/> <clone/> <bbox w="80.0" h="40.0" x="10180.0" y="1120.0"/> </glyph> <glyph class="macromolecule" id="s7519_sa5063" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 4 HUGO:CASP4 hgnc_id:HGNC:1505 HGNC:1505 ENTREZ:837 UNIPROT:P49662 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="cleaved~Caspase4*"/> <clone/> <bbox w="80.0" h="40.0" x="8460.0" y="3950.0"/> <glyph class="unit of information" id="_e1dea13d-9005-49ce-8e66-383ad756c157"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8475.0" y="3945.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7519_sa5387" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 4 HUGO:CASP4 hgnc_id:HGNC:1505 HGNC:1505 ENTREZ:837 UNIPROT:P49662 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 References_end </body> </html> </notes> <label text="cleaved~Caspase4*"/> <clone/> <bbox w="80.0" h="40.0" x="10310.0" y="1120.0"/> <glyph class="unit of information" id="_9eeef73c-d39c-4d41-88ff-289857ca9adb"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10325.0" y="1115.0"/> </glyph> </glyph> <glyph class="complex" id="s261_csa478" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAK1:TMBIM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2L1:BAK1"/> <bbox w="100.0" h="120.0" x="10473.906" y="4660.0"/> <glyph class="macromolecule" id="s216_sa5069"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="10483.906" y="4720.0"/> </glyph> <glyph class="macromolecule" id="s206_sa5070"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="TMBIM6"/> <bbox w="80.0" h="40.0" x="10483.906" y="4670.0"/> </glyph> </glyph> <glyph class="complex" id="s262_csa479" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IRE1-alpha*:Unfolded protein* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: protein* PMID:23850759 References_end </body> </html> </notes> <label text="IRE1:unfolded protein*"/> <bbox w="190.0" h="135.0" x="9188.906" y="4892.5"/> <glyph class="macromolecule" id="s10_sa5071"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="40.0" x="9235.829" y="4944.8076"/> <glyph class="state variable" id="_762b1c74-1563-4e1b-b541-30597223f0e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9287.397" y="4939.8076"/> </glyph> <glyph class="unit of information" id="_324d542c-a942-4e9a-ae5d-45b2a85149c8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9253.329" y="4939.8076"/> </glyph> </glyph> <glyph class="macromolecule" id="s7548_sa5072"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="9198.906" y="4907.5"/> <glyph class="state variable" id="_6ff334c7-d966-4d1b-9bf9-9d9eacebfd0e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9250.695" y="4932.5"/> </glyph> <glyph class="state variable" id="_ea2065b7-8518-4353-89e6-514e76585a9b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9193.906" y="4911.2866"/> </glyph> <glyph class="state variable" id="_f5dd2eac-9098-45d8-8a26-2dc6f81e190e"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="9308.167" y="4902.5"/> </glyph> <glyph class="unit of information" id="_40e8988d-6548-4349-9c5c-07b2151a3a5c"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9253.906" y="4902.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s10_sa5073"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="40.0" x="9248.906" y="4957.5"/> <glyph class="state variable" id="_7b5f4aa0-0f6f-4bc6-aa61-6867ee173b1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9300.475" y="4952.5"/> </glyph> <glyph class="unit of information" id="_90bcf767-9264-4e0b-a4c9-ba7d0b8d00e9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9266.406" y="4952.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s320_csa480" compartmentRef="c40_ca42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG5:CASP8:FADD:LC3*:SQSTM1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: CASP8:FADD:LC3*:SQSTM1:ATG5 PMID:26587781 intracellular death-inducing signaling complex (iDISC) References_end </body> </html> </notes> <label text="CASP8:FADD:LC3*:SQSTM1:ATG5"/> <bbox w="215.0" h="150.0" x="11232.5" y="5895.0"/> <glyph class="macromolecule" id="s321_sa5074"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microtubule-associated protein 1 light chain 3 alpha HUGO:MAP1LC3A HGNC:6838 ENTREZ:84557 UNIPROT:Q9H492 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: PMID:15325588 PMID:23725295 LC3-I is transformed into LC3-II/Atg8 thanks to Phosphatidyl ethanolamine PMID:24070470 References_end </body> </html> </notes> <label text="LC3*"/> <bbox w="80.0" h="40.0" x="11357.5" y="5905.0"/> <glyph class="state variable" id="_ce70b94a-c415-4ed4-bfe0-2ade441a0cb6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11432.5" y="5911.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s322_sa5075"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 hgnc_id:HGNC:11280 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 References_end </body> </html> </notes> <label text="SQSTM1 "/> <bbox w="80.0" h="40.0" x="11360.0" y="5950.0"/> </glyph> <glyph class="macromolecule" id="s323_sa5076"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="11357.5" y="5995.0"/> </glyph> <glyph class="macromolecule" id="s325_sa5077"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="11250.0" y="5920.0"/> </glyph> <glyph class="macromolecule" id="s325_sa5078"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="11260.0" y="5930.0"/> </glyph> <glyph class="macromolecule" id="s326_sa5079"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 HUGO:CASP8 hgnc_id:HGNC:1509 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end </body> </html> </notes> <label text="CASP8"/> <bbox w="80.0" h="40.0" x="11250.0" y="5970.0"/> <glyph class="state variable" id="_3e4b6605-c471-47e0-a1e4-6e1ec430b03e"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="11312.5" y="5976.779"/> </glyph> </glyph> <glyph class="macromolecule" id="s326_sa5080"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 HUGO:CASP8 hgnc_id:HGNC:1509 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end </body> </html> </notes> <label text="CASP8"/> <bbox w="80.0" h="40.0" x="11260.0" y="5980.0"/> <glyph class="state variable" id="_579ceb30-1c4a-4dfc-9dfc-24ad863f2cf7"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="11322.5" y="5986.779"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s263_csa481" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:MCL1:Unfolded protein* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 IRE1a activation is an early event which diminished upon prolonged stress References_end </body> </html> </notes> <label text="IRE1a:IRE1a-activated"/> <bbox w="185.0" h="200.0" x="9478.906" y="4900.0"/> <glyph class="macromolecule multimer" id="s33_sa5081"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="MCL1"/> <bbox w="86.0" h="76.0" x="9520.906" y="4952.0"/> <glyph class="unit of information" id="_03b20d51-8e2a-4db8-a655-37e96f65fade"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="9553.906" y="4947.0"/> </glyph> <glyph class="state variable" 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y="5030.0"/> </glyph> <glyph class="macromolecule" id="s505_sa5083"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="9498.906" y="4915.0"/> <glyph class="state variable" id="_4ed51208-f1d9-4395-9c48-76081db9f478"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9550.695" y="4940.0"/> </glyph> <glyph class="state variable" id="_27b56944-a9c9-404d-9a79-66f3f3f61f20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9493.906" y="4918.7866"/> </glyph> <glyph class="state variable" id="_92f5277b-d747-4922-82ec-84ace365b77a"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="9608.167" y="4910.0"/> </glyph> <glyph class="unit of information" id="_f6d82ecd-33e6-4c62-bcf2-d597eb98286f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9553.906" y="4910.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s396_csa482" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF2B1:EIF2B2:EIF2S1:EIF2S2:GDP:NDUFA7:NDUFB4:NDUFB5:NDUFB6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:16246152 References_end </body> </html> </notes> <label text="EIF2B*:EIF2*:GDP"/> <bbox w="190.0" h="237.5" x="9095.0" y="6381.25"/> <glyph class="macromolecule" id="s7549_sa5084"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit alpha HUGO:EIF2B1 hgnc_id:HGNC:3257 HGNC:3257 ENTREZ:1967 UNIPROT:Q14232 Identifiers_end </body> </html> </notes> <label text="EIF2B1"/> <bbox w="80.0" h="40.0" x="9105.0" y="6391.25"/> </glyph> <glyph class="macromolecule" id="s7550_sa5085"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit beta HUGO:EIF2B2 hgnc_id:HGNC:3258 HGNC:3258 ENTREZ:8892 UNIPROT:P49770 Identifiers_end </body> </html> </notes> <label text="EIF2B2"/> <bbox w="80.0" h="40.0" x="9105.0" y="6431.25"/> </glyph> <glyph class="macromolecule" id="s390_sa5086"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit gamma HUGO:EIF2B3 hgnc_id:HGNC:3259 HGNC:3259 ENTREZ:8891 UNIPROT:Q9NR50 Identifiers_end </body> </html> </notes> <label text="NDUFB6"/> <bbox w="80.0" h="40.0" x="9105.0" y="6471.25"/> </glyph> <glyph class="macromolecule" id="s391_sa5087"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit delta HUGO:EIF2B4 hgnc_id:HGNC:3260 HGNC:3260 ENTREZ:8890 UNIPROT:Q9UI10 Identifiers_end </body> </html> </notes> <label text="NDUFB4"/> <bbox w="80.0" h="40.0" x="9105.0" y="6511.25"/> </glyph> <glyph class="macromolecule" id="s392_sa5088"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> from Uniprot:"homodimer, by similarity" ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 2B subunit epsilon HUGO:EIF2B5 hgnc_id:HGNC:3261 HGNC:3261 ENTREZ:8893 UNIPROT:Q13144 Identifiers_end </body> </html> </notes> <label text="NDUFA7"/> <bbox w="80.0" h="40.0" x="9105.0" y="6551.25"/> </glyph> <glyph class="macromolecule" id="s395_sa5089"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit alpha HUGO:EIF2S1 hgnc_id:HGNC:3265 HGNC:3265 ENTREZ:1965 UNIPROT:P05198 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 eukaryotic translation initiation factor 2 subunit alpha PMID:12667446 PMID:16246152 PMID:12601012 References_end </body> </html> </notes> <label text="EIF2S1"/> <bbox w="80.0" h="40.0" x="9195.0" y="6408.75"/> <glyph class="state variable" id="_879aaba1-b0f4-4c93-8402-bac576779348"> <state value="P" variable="Ser51"/> <bbox w="40.0" h="10.0" x="9231.949" y="6403.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s393_sa5090"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit beta HUGO:EIF2S2 hgnc_id:HGNC:3266 HGNC:3266 ENTREZ:8894 UNIPROT:P20042 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: eukaryotic translation initiation factor 2 subunit beta PMID:23850759 References_end </body> </html> </notes> <label text="EIF2S2"/> <bbox w="80.0" h="40.0" x="9194.543" y="6456.875"/> </glyph> <glyph class="macromolecule" id="s386_sa5091"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 2 subunit gamma HUGO:EIF2S3 hgnc_id:HGNC:3267 HGNC:3267 ENTREZ:1968 UNIPROT:P41091 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: eukaryotic translation initiation factor 2 subunit gamma PMID:23850759 References_end </body> </html> </notes> <label text="NDUFB5"/> <bbox w="80.0" h="40.0" x="9195.3125" y="6501.875"/> </glyph> <glyph class="simple chemical" id="s394_sa5092"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:65180 MODULE:ER_STRESS PMID:23850759 </body> </html> </notes> <label text="GDP"/> <bbox w="70.0" h="25.0" x="9199.6875" y="6546.25"/> </glyph> </glyph> <glyph class="complex" id="s7525_csa483" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF2B1:EIF2B3:EIF2B4:EIF2B5:NDUFS1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:16246152 References_end </body> </html> </notes> <label text="EIF2B*"/> <clone/> <bbox w="100.0" h="235.0" x="9340.0" y="6235.0"/> <glyph class="macromolecule" id="s346_sa5093"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit alpha HUGO:EIF2B1 hgnc_id:HGNC:3257 HGNC:3257 ENTREZ:1967 UNIPROT:Q14232 Identifiers_end </body> </html> </notes> <label text="EIF2B1"/> <clone/> <bbox w="80.0" h="40.0" x="9350.0" y="6245.0"/> </glyph> <glyph class="macromolecule" id="s347_sa5094"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit beta HUGO:EIF2B2 hgnc_id:HGNC:3258 HGNC:3258 ENTREZ:8892 UNIPROT:P49770 Identifiers_end </body> </html> </notes> <label text="NDUFS1"/> <clone/> <bbox w="80.0" h="40.0" x="9350.0" y="6285.0"/> </glyph> <glyph class="macromolecule" id="s348_sa5095"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit gamma HUGO:EIF2B3 hgnc_id:HGNC:3259 HGNC:3259 ENTREZ:8891 UNIPROT:Q9NR50 Identifiers_end </body> </html> </notes> <label text="EIF2B3"/> <clone/> <bbox w="80.0" h="40.0" x="9350.0" y="6325.0"/> </glyph> <glyph class="macromolecule" id="s7552_sa5096"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit delta HUGO:EIF2B4 hgnc_id:HGNC:3260 HGNC:3260 ENTREZ:8890 UNIPROT:Q9UI10 Identifiers_end </body> </html> </notes> <label text="EIF2B4"/> <clone/> <bbox w="80.0" h="40.0" x="9350.0" y="6365.0"/> </glyph> <glyph class="macromolecule" id="s7566_sa5097"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit epsilon HUGO:EIF2B5 hgnc_id:HGNC:3261 HGNC:3261 ENTREZ:8893 UNIPROT:Q13144 Identifiers_end </body> </html> </notes> <label text="EIF2B5"/> <clone/> <bbox w="80.0" h="40.0" x="9350.0" y="6405.0"/> </glyph> </glyph> <glyph class="complex" id="s7525_csa502" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF2B1:EIF2B3:EIF2B4:EIF2B5:NDUFS1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:16246152 References_end </body> </html> </notes> <label text="EIF2B*"/> <clone/> <bbox w="100.0" h="235.0" x="10210.0" y="6122.5"/> <glyph class="macromolecule" id="s346_sa5140"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit alpha HUGO:EIF2B1 hgnc_id:HGNC:3257 HGNC:3257 ENTREZ:1967 UNIPROT:Q14232 Identifiers_end </body> </html> </notes> <label text="EIF2B1"/> <clone/> <bbox w="80.0" h="40.0" x="10220.0" y="6132.5"/> </glyph> <glyph class="macromolecule" id="s347_sa5141"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit beta HUGO:EIF2B2 hgnc_id:HGNC:3258 HGNC:3258 ENTREZ:8892 UNIPROT:P49770 Identifiers_end </body> </html> </notes> <label text="NDUFS1"/> <clone/> <bbox w="80.0" h="40.0" x="10220.0" y="6172.5"/> </glyph> <glyph class="macromolecule" id="s348_sa5142"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit gamma HUGO:EIF2B3 hgnc_id:HGNC:3259 HGNC:3259 ENTREZ:8891 UNIPROT:Q9NR50 Identifiers_end </body> </html> </notes> <label text="EIF2B3"/> <clone/> <bbox w="80.0" h="40.0" x="10220.0" y="6212.5"/> </glyph> <glyph class="macromolecule" id="s7552_sa5143"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit delta HUGO:EIF2B4 hgnc_id:HGNC:3260 HGNC:3260 ENTREZ:8890 UNIPROT:Q9UI10 Identifiers_end </body> </html> </notes> <label text="EIF2B4"/> <clone/> <bbox w="80.0" h="40.0" x="10220.0" y="6252.5"/> </glyph> <glyph class="macromolecule" id="s7566_sa5144"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2B subunit epsilon HUGO:EIF2B5 hgnc_id:HGNC:3261 HGNC:3261 ENTREZ:8893 UNIPROT:Q13144 Identifiers_end </body> </html> </notes> <label text="EIF2B5"/> <clone/> <bbox w="80.0" h="40.0" x="10220.0" y="6292.5"/> </glyph> </glyph> <glyph class="complex" id="s243_csa484" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KEAP1:NFE2L2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1:NFE2L2"/> <bbox w="100.0" h="120.0" x="8370.0" y="6110.0"/> <glyph class="macromolecule" id="s7554_sa5098"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <bbox w="80.0" h="40.0" x="8380.0" y="6120.0"/> </glyph> <glyph class="macromolecule" id="s7555_sa5099"> <notes> <html 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compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CALR:Ca2+ Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CALR:Ca2+"/> <bbox w="100.0" h="120.0" x="8600.0" y="5270.0"/> <glyph class="macromolecule" id="s150_sa5100"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calreticulin HUGO:CALR hgnc_id:HGNC:1455 HGNC:1455 ENTREZ:811 UNIPROT:P27797 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="CALR"/> <bbox w="80.0" h="40.0" x="8610.0" y="5280.0"/> </glyph> <glyph class="simple chemical" id="s151_sa5101"> <label text="Ca2+"/> <bbox w="32.5" h="32.5" x="8633.75" y="5333.75"/> </glyph> </glyph> <glyph class="complex" id="s7526_csa486" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:TMBIM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2L1:TMBIM6"/> <bbox w="100.0" h="125.0" x="8120.0" y="4767.5"/> <glyph class="macromolecule" id="s179_sa5102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="8130.0" y="4772.5"/> </glyph> <glyph class="macromolecule" id="s180_sa5105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transmembrane BAX inhibitor motif containing 6 HUGO:TMBIM6 HGNC:11723 ENTREZ:7009 UNIPROT:P55061 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label 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</head> <body> Identifiers_begin: transmembrane BAX inhibitor motif containing 6 HUGO:TMBIM6 HGNC:11723 ENTREZ:7009 UNIPROT:P55061 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="TMBIM6"/> <bbox w="80.0" h="50.0" x="8130.0" y="4685.0"/> <glyph class="unit of information" id="_c8a315bb-0a8a-4254-95a6-e04bab9c746e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8147.5" y="4680.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s182_sa5104"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="8130.0" y="4640.0"/> <glyph class="state variable" id="_d8a1d6c5-ccae-4817-aff5-d2dbde55c3ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8148.4316" y="4635.0"/> </glyph> <glyph class="state variable" id="_a44c543f-9c39-42c0-a99d-18e1a6d825c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8181.5684" y="4635.0"/> </glyph> <glyph class="state variable" id="_57f02dd4-77ba-4ac3-add0-a4b25ca388ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8125.0" y="4655.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s249_csa488" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IRE1-alpha*:TMBIM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="IRE1*:TMBIM6"/> <bbox w="103.28125" h="140.0" x="8746.719" y="4890.0"/> <glyph class="macromolecule" id="s197_sa5106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="70.0" x="8756.719" y="4895.0"/> <glyph class="state variable" id="_0fb25570-4a4e-4df8-b6a3-e9f1bb049600"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8808.287" y="4890.0"/> </glyph> <glyph class="unit of information" id="_5b0c102c-5e2d-469e-b3e3-9d55782ab3fe"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8774.219" y="4890.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s196_sa5107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transmembrane BAX inhibitor motif containing 6 HUGO:TMBIM6 HGNC:11723 ENTREZ:7009 UNIPROT:P55061 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="TMBIM6"/> <bbox w="80.0" h="50.0" x="8756.719" y="4955.0"/> <glyph class="unit of information" id="_2be9fd94-97ac-4f00-af4e-6693c969fe28"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8774.219" y="4950.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s258_csa489" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BCL2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2:BAX"/> <bbox w="100.0" h="120.0" x="10103.906" y="4660.0"/> <glyph class="macromolecule" id="s208_sa5108"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="10113.906" y="4670.0"/> <glyph class="state variable" id="_530b0a5d-eb09-46ad-9d2c-e25ad5658752"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10132.338" y="4665.0"/> </glyph> <glyph class="state variable" id="_6700a04d-f2fc-4975-b5c0-f1c5fb02cf54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10165.475" y="4665.0"/> </glyph> <glyph class="state variable" id="_5c64cc5a-0975-46d5-a589-9ab5350177af"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10108.906" y="4685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7557_sa5109"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10113.906" y="4720.0"/> <glyph class="state variable" id="_544109d9-4f1e-4b26-bc28-f2980db23a58"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="10114.983" y="4715.0"/> </glyph> <glyph class="state variable" id="_3590e583-1e0d-4535-80ea-fefbf7f0ecb6"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="10159.99" y="4715.0"/> </glyph> <glyph class="state variable" id="_3f6d55f0-70e6-4860-a307-9cd431685b88"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10160.228" y="4755.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s563_csa490" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CHUK:IKBKB:IKBKG Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: kinase PMID:23430059 References_end </body> </html> </notes> <label text="IkB kinase (IKK)"/> <bbox w="100.0" h="150.0" x="10070.0" y="5115.0"/> <glyph class="macromolecule" id="s514_sa5110"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: conserved helix-loop-helix ubiquitous kinase HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 IKBK-alpha synonym:IKBKA synonym:IKK_alpha_ Maps_Modules_end References_end </body> </html> </notes> <label text="CHUK"/> <bbox w="80.0" h="40.0" x="10080.0" y="5125.0"/> </glyph> <glyph class="macromolecule" id="s515_sa5111"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of nuclear factor kappa B kinase subunit beta HUGO:IKBKB hgnc_id:HGNC:5960 HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="IKBKB"/> <bbox w="80.0" h="40.0" x="10080.0" y="5165.0"/> <glyph class="state variable" id="_6668c162-5b34-441f-99d1-65eddeb73692"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10155.0" y="5180.0"/> </glyph> <glyph class="state variable" id="_a6d21fad-11a6-4afa-ba6f-0e64a1370ed7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10075.0" y="5180.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s564_sa5112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <bbox w="80.0" h="40.0" x="10080.0" y="5205.0"/> </glyph> </glyph> <glyph class="complex" id="s260_csa491" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BCL2-XL* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2L1:BAX"/> <bbox w="100.0" h="120.0" x="10353.906" y="4660.0"/> <glyph class="macromolecule" id="s213_sa5113"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10363.906" y="4720.0"/> <glyph class="state variable" id="_ec092d84-c842-4aef-a4bb-c9795c7fe91e"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="10364.983" y="4715.0"/> </glyph> <glyph class="state variable" id="_c1247e22-4517-449d-8992-67d65345ad5c"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="10409.99" y="4715.0"/> </glyph> <glyph class="state variable" id="_42a7df6d-b118-421b-a2b0-dbd0085c5d3f"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10410.228" y="4755.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s214_sa5114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="10363.906" y="4670.0"/> </glyph> </glyph> <glyph class="complex" id="s259_csa492" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAK1:TMBIM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BCL2:BAK1"/> <bbox w="100.0" h="120.0" x="10233.906" y="4660.0"/> <glyph class="macromolecule" id="s203_sa5115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="TMBIM6"/> <bbox w="80.0" h="40.0" x="10243.906" y="4670.0"/> <glyph class="state variable" id="_ecb5f034-d7ee-49d3-8c8f-91f2fb65d125"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10262.338" y="4665.0"/> </glyph> <glyph class="state variable" id="_a911fa18-210b-4850-a27b-42a2cf36a06c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10295.475" y="4665.0"/> </glyph> <glyph class="state variable" id="_e0dc7e0e-d8ba-48f3-93c7-a9769412889e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10238.906" y="4685.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s211_sa5116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BAK1"/> <bbox w="80.0" h="40.0" x="10243.906" y="4720.0"/> </glyph> </glyph> <glyph class="complex" id="s250_csa493" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:IRE1-alpha* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BAX:IRE1*"/> <bbox w="100.0" h="120.0" x="9342.1875" y="4000.0"/> <glyph class="macromolecule" id="s223_sa5117"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="9352.1875" y="4010.0"/> <glyph class="state variable" id="_69d269f5-2710-461e-b154-5a07768b4edd"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="9353.265" y="4005.0"/> </glyph> <glyph class="state variable" id="_891e2f74-63ce-4ba6-b43f-314e5eae70fa"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="9398.271" y="4005.0"/> </glyph> <glyph class="state variable" id="_3f53708d-147b-408f-b13f-187c338e5d04"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="9398.509" y="4045.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s227_sa5118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="45.0" x="9352.1875" y="4057.5"/> <glyph class="state variable" id="_7b89e57b-eb86-4c7a-a89d-fceb3fd465df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9403.756" y="4052.5"/> </glyph> <glyph class="unit of information" id="_5d4496f2-0d67-4073-b7f2-eaaa42e98e48"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9369.6875" y="4052.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s7527_csa494" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:IRE1-alpha* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="BAK1:IRE1*"/> <bbox w="94.375" h="125.0" x="9468.906" y="4007.5"/> <glyph class="macromolecule" id="s222_sa5119"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="9478.906" y="4017.5"/> </glyph> <glyph class="macromolecule" id="s225_sa5120"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 HUGO:CASP8 hgnc_id:HGNC:1509 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end </body> </html> </notes> <label text="CASP8"/> <bbox w="80.0" h="40.0" x="10981.786" y="5900.7144"/> <glyph class="state variable" id="_8c8f9bfd-a150-4789-9385-4c9d9b03ca77"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="11044.286" y="5907.493"/> </glyph> </glyph> <glyph class="macromolecule" id="s7560_sa5132"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 HUGO:CASP8 hgnc_id:HGNC:1509 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end </body> </html> </notes> <label text="CASP8"/> <bbox w="80.0" h="40.0" x="10981.786" y="5900.7144"/> <glyph class="state variable" id="_c129348a-e840-44a0-9c8f-075357483a90"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="11044.286" y="5907.493"/> </glyph> </glyph> <glyph class="macromolecule" id="s7560_sa5133"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 8 HUGO:CASP8 hgnc_id:HGNC:1509 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 Identifiers_end </body> </html> </notes> <label text="CASP8"/> <bbox w="80.0" h="40.0" x="10991.786" y="5910.7144"/> <glyph class="state variable" id="_d2e2e0ee-995e-426f-ac41-158ad0eb554d"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="11054.286" y="5917.493"/> </glyph> </glyph> <glyph class="macromolecule" id="s7562_sa5134"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Fas (TNFRSF6)-associated via death domain HUGO:FADD HGNC:3573 ENTREZ:8772 UNIPROT:Q13158 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:9488730 PMID:20531300 PMID:28574505 PMID:11003656 PMID:26972597 FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce apoptosis. 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References_end </body> </html> </notes> <label text="FADD"/> <bbox w="80.0" h="40.0" x="10998.214" y="5869.2856"/> </glyph> </glyph> <glyph class="complex" id="s7532_csa500" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATF6:BiP* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF6:BiP*"/> <bbox w="100.0" h="120.0" x="11063.906" y="4890.0"/> <glyph class="macromolecule" id="s7564_sa5136"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 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Identifiers_begin: eukaryotic translation initiation factor 2 subunit alpha HUGO:EIF2S1 hgnc_id:HGNC:3265 HGNC:3265 ENTREZ:1965 UNIPROT:P05198 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 eukaryotic translation initiation factor 2 subunit alpha PMID:12667446 PMID:16246152 PMID:12601012 References_end </body> </html> </notes> <label text="EIF2S1"/> <bbox w="80.0" h="40.0" x="10110.0" y="6505.0"/> <glyph class="state variable" id="_54f01d71-f861-4cdd-85f3-bbfb131a1c9e"> <state value="" variable="Ser51"/> <bbox w="35.0" h="10.0" x="10149.449" y="6500.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s191_sa5151"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit beta HUGO:EIF2S2 hgnc_id:HGNC:3266 HGNC:3266 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit beta HUGO:EIF2S2 hgnc_id:HGNC:3266 HGNC:3266 ENTREZ:8894 UNIPROT:P20042 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: eukaryotic translation initiation factor 2 subunit beta PMID:23850759 References_end </body> </html> </notes> <label text="NDUFS4"/> <bbox w="80.0" h="40.0" x="9919.543" y="6528.125"/> </glyph> <glyph class="macromolecule" id="s374_sa5164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 subunit gamma HUGO:EIF2S3 hgnc_id:HGNC:3267 HGNC:3267 ENTREZ:1968 UNIPROT:P41091 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: eukaryotic translation initiation factor 2 subunit gamma PMID:23850759 References_end </body> </html> </notes> <label text="NDUFB2"/> <bbox w="80.0" h="40.0" x="9920.3125" y="6573.125"/> </glyph> </glyph> <glyph class="complex" id="s7537_csa508" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATP:MT-ND4L Identifiers_end </body> </html> </notes> <label text="GCN2:ATP"/> <bbox w="100.0" h="100.0" x="9560.0" y="6280.0"/> <glyph class="macromolecule" id="s399_sa5165"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 4 HUGO:EIF2AK4 hgnc_id:HGNC:19687 HGNC:19687 ENTREZ:440275 UNIPROT:Q9P2K8 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:12667446 GCN2 is activated by uncharged tRNAs PMID:15964839 References_end </body> </html> </notes> <label text="MT-ND4L"/> <bbox w="80.0" h="40.0" x="9570.0" y="6290.0"/> </glyph> <glyph class="simple chemical" id="s400_sa5166"> <label text="ATP"/> <bbox w="70.0" h="25.0" x="9575.0" y="6337.5"/> </glyph> </glyph> <glyph class="complex" id="s7538_csa509" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATF3:ATF4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19164757 References_end </body> </html> </notes> <label text="ATF3:ATF4"/> <bbox w="100.0" h="130.0" x="10712.266" y="7430.0"/> <glyph class="macromolecule" id="s403_sa5167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 3 HUGO:ATF3 hgnc_id:HGNC:785 HGNC:785 ENTREZ:467 UNIPROT:P18847 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF3"/> <bbox w="80.0" h="40.0" x="10722.266" y="7440.0"/> </glyph> <glyph class="macromolecule" id="s7539_sa5168"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 4 HUGO:ATF4 hgnc_id:HGNC:786 HGNC:786 ENTREZ:468 UNIPROT:P18848 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF4"/> <bbox w="80.0" h="40.0" x="10722.266" y="7490.0"/> </glyph> </glyph> <glyph class="complex" id="s565_csa510" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NDUFS8:NPL4*:UFD1*:p97* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: 12847084 References_end </body> </html> </notes> <label text="p97*:UFD1*:NPL4*"/> <bbox w="100.0" h="180.0" x="11753.906" y="4850.0"/> <glyph class="macromolecule" id="s566_sa5169"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="p97*"/> <bbox w="80.0" h="40.0" x="11763.906" y="4860.0"/> </glyph> <glyph class="macromolecule" id="s7571_sa5170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NPL4 homolog, ubiquitin recognition factor HUGO:NPLOC4 hgnc_id:HGNC:18261 HGNC:18261 ENTREZ:55666 UNIPROT:Q8TAT6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:16186509 References_end </body> </html> </notes> <label text="NPL4*"/> <bbox w="80.0" h="40.0" x="11763.906" y="4900.0"/> </glyph> <glyph class="macromolecule" id="s568_sa5171"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquitin recognition factor in ER associated degradation 1 HUGO:UFD1 hgnc_id:HGNC:12520 HGNC:12520 ENTREZ:7353 UNIPROT:Q92890 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:16186509 References_end </body> </html> </notes> <label text="UFD1*"/> <bbox w="80.0" h="40.0" x="11763.906" y="4940.0"/> </glyph> <glyph class="simple chemical" id="s442_sa5172"> <label text="NDUFS8"/> <bbox w="70.0" h="25.0" x="11768.906" y="4987.5"/> </glyph> </glyph> <glyph class="complex" id="s439_csa511" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NDUFS2:NDUFV2:NPL4* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: 12847084 References_end </body> </html> </notes> <label text="p97*:UFD1*:NPL4*"/> <bbox w="97.14286" h="157.5" x="11751.429" y="4591.25"/> <glyph class="macromolecule" id="s436_sa5173"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="NDUFS2"/> <bbox w="80.0" h="40.0" x="11761.429" y="4603.75"/> </glyph> <glyph class="macromolecule" id="s437_sa5174"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NPL4 homolog, ubiquitin recognition factor HUGO:NPLOC4 hgnc_id:HGNC:18261 HGNC:18261 ENTREZ:55666 UNIPROT:Q8TAT6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:16186509 References_end </body> </html> </notes> <label text="NPL4*"/> <bbox w="80.0" h="40.0" x="11761.429" y="4643.75"/> </glyph> <glyph class="macromolecule" id="s438_sa5175"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ubiquitin recognition factor in ER associated degradation 1 HUGO:UFD1 hgnc_id:HGNC:12520 HGNC:12520 ENTREZ:7353 UNIPROT:Q92890 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:16186509 References_end </body> </html> </notes> <label text="NDUFV2"/> <bbox w="80.0" h="40.0" x="11761.429" y="4683.75"/> </glyph> </glyph> <glyph class="complex" id="s7540_csa512" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Eeyarestatin I:NDUFB1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 References_end </body> </html> </notes> <label text="p97:Eer1*"/> <bbox w="100.0" h="110.0" x="10953.906" y="4350.0"/> <glyph class="simple chemical" id="s455_sa5176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Eeyarestatin I, EerI MODULE:ER_STRESS PMID:19164757 </body> </html> </notes> <label text="Eeyarestatin I"/> <bbox w="80.0" h="30.0" x="10963.906" y="4365.0"/> <glyph class="unit of information" id="_f9b7f345-05b6-4373-9444-2d87a84d1073"> <label text="drug"/> <bbox w="25.0" h="10.0" x="10991.406" y="4360.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s456_sa5177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="NDUFB1"/> <bbox w="80.0" h="40.0" x="10963.906" y="4400.0"/> </glyph> </glyph> <glyph class="complex" id="s7541_csa513" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NDUFA8:p97* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: enzymes* PMID:19164757 PMID:18199748 References_end </body> </html> </notes> <label text="p97*:Ubiquinating enzymes*"/> <bbox w="160.0" h="120.0" x="11280.0" y="4480.0"/> <glyph class="macromolecule" id="s460_sa5178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 References_end </body> </html> </notes> <label text="NDUFA8"/> <bbox w="130.0" h="40.0" x="11295.0" y="4530.0"/> </glyph> <glyph class="macromolecule" id="s459_sa5179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="p97*"/> <bbox w="80.0" h="40.0" x="11320.0" y="4490.0"/> </glyph> </glyph> <glyph class="complex" id="s502_csa514" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:NDUFB9:SEL1L:SYVN1:VIMP:p97* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 References_end </body> </html> </notes> <label text="Derlin*:VIMP*:p97*:SYVN1:HERP*:SEL1L"/> <bbox w="190.0" h="160.0" x="11645.0" y="4350.0"/> <glyph class="macromolecule" id="s485_sa5180"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: derlin 1 HUGO:DERL1 hgnc_id:HGNC:28454 HGNC:28454 ENTREZ:79139 UNIPROT:Q9BUN8 derlin 2 HUGO:DERL2 hgnc_id:HGNC:17943 HGNC:17943 ENTREZ:51009 UNIPROT:Q9GZP9 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="Ca2+"/> <bbox w="80.0" h="40.0" x="11745.0" y="4360.0"/> </glyph> <glyph class="macromolecule" id="s482_sa5181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: selenoprotein S HUGO:SELENOS hgnc_id:HGNC:30396 HGNC:30396 ENTREZ:55829 UNIPROT:Q9BQE4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:18199748 PMID:19509052 References_end </body> </html> </notes> <label text="VIMP"/> <bbox w="80.0" h="40.0" x="11745.0" y="4400.0"/> </glyph> <glyph class="macromolecule" id="s7675_sa5182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="p97*"/> <bbox w="80.0" h="40.0" x="11740.0" y="4440.0"/> </glyph> <glyph class="macromolecule" id="s7572_sa5183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: synoviolin 1 HUGO:SYVN1 hgnc_id:HGNC:20738 HGNC:20738 ENTREZ:84447 UNIPROT:Q86TM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 PMID:18360008 HRD1 References_end </body> </html> </notes> <label text="SYVN1"/> <bbox w="80.0" h="40.0" x="11655.0" y="4360.0"/> </glyph> <glyph class="macromolecule" id="s490_sa5184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homocysteine inducible ER protein with ubiquitin like domain 1 HUGO:HERPUD1 hgnc_id:HGNC:13744 HGNC:13744 ENTREZ:9709 UNIPROT:Q15011 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="NDUFB9"/> <bbox w="80.0" h="40.0" x="11655.0" y="4400.0"/> </glyph> <glyph class="macromolecule" id="s501_sa5185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SEL1L ERAD E3 ligase adaptor subunit HUGO:SEL1L hgnc_id:HGNC:10717 HGNC:10717 ENTREZ:6400 UNIPROT:Q9UBV2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:16186509 References_end </body> </html> </notes> <label text="SEL1L"/> <bbox w="80.0" h="40.0" x="11655.0" y="4440.0"/> </glyph> </glyph> <glyph class="complex" id="s7542_csa515" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BiP*:PERK* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="PERK*:BiP*"/> <bbox w="100.0" h="120.0" x="10353.906" y="4890.0"/> <glyph class="macromolecule" id="s13_sa5186"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: eukaryotic translation initiation factor 2 alpha kinase 3 HUGO:EIF2AK3 hgnc_id:HGNC:3255 HGNC:3255 ENTREZ:9451 UNIPROT:Q9NZJ5 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 References_end </body> </html> </notes> <label text="PERK*"/> <bbox w="80.0" h="40.0" x="10363.906" y="4900.0"/> <glyph class="state variable" id="_21dfda02-37e9-4b4e-8a89-fb08ce7334b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10438.906" y="4923.284"/> </glyph> <glyph class="state variable" id="_fb909e68-68b4-488f-8b5d-2c43dc9b2f6c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10438.906" y="4906.716"/> </glyph> </glyph> <glyph class="macromolecule" id="s14_sa5187"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <bbox w="80.0" h="40.0" x="10370.0" y="4940.0"/> </glyph> </glyph> <glyph class="complex" id="s526_csa516" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFKB*:NFKBIA Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB*:NFKBIA"/> <bbox w="100.0" h="120.0" x="10150.0" y="5270.0"/> <glyph class="macromolecule" id="s527_sa5188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor kappa B subunit 2 HUGO:NFKB2 hgnc_id:HGNC:7795 HGNC:7795 ENTREZ:4791 UNIPROT:Q00653 RELA proto-oncogene, NF-kB subunit HUGO:RELA hgnc_id:HGNC:9955 HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 RELB proto-oncogene, NF-kB subunit HUGO:RELB hgnc_id:HGNC:9956 HGNC:9956 ENTREZ:5971 UNIPROT:Q01201 nuclear factor kappa B subunit 1 HUGO:NFKB1 hgnc_id:HGNC:7794 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 REL proto-oncogene, NF-kB subunit HUGO:REL hgnc_id:HGNC:9954 HGNC:9954 ENTREZ:5966 UNIPROT:Q04864 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB*"/> <bbox w="80.0" h="40.0" x="10160.0" y="5320.0"/> </glyph> <glyph class="macromolecule" id="s528_sa5189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha HUGO:NFKBIA HGNC:7797 ENTREZ:4792 UNIPROT:P25963 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:I_kappa_B-_alpha_ References_end </body> </html> </notes> <label text="NFKBIA"/> <bbox w="80.0" h="40.0" x="10160.0" y="5280.0"/> <glyph class="state variable" id="_b87fb287-60b2-4f89-b08c-74dc6b0fbdf4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10178.432" y="5275.0"/> </glyph> <glyph class="state variable" id="_d49f9ad9-4335-40d0-9ff9-b5b38977abdd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10211.568" y="5275.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s546_csa518" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:TMBIM3 Identifiers_end </body> </html> </notes> <label text="BAX:TMBIM3"/> <bbox w="100.0" h="120.0" x="9823.906" y="4880.0"/> <glyph class="macromolecule" id="s547_sa5193"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="9833.906" y="4890.0"/> <glyph 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PMID:23850759 PMID:23430059 Binding of Bax and Bak to IRE1 is negatively regulated by Bax Inhibitor 1 (BI-1), a transmembrane protein localized to the ER and nuclear envelope References_end </body> </html> </notes> <label text="TMBIM3"/> <bbox w="80.0" h="50.0" x="9833.906" y="4935.0"/> <glyph class="state variable" id="_f5a5a737-830f-4de9-925d-1692cb261034"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9885.475" y="4930.0"/> </glyph> <glyph class="unit of information" id="_62c20231-e761-4c92-90eb-18ef7acb372d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9851.406" y="4930.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s7543_csa519" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IDH3C:TMBIM3 Identifiers_end </body> </html> </notes> <label text="BAK1:TMBIM3"/> <bbox w="100.0" h="120.0" x="9693.906" y="4880.0"/> <glyph class="macromolecule" id="s550_sa5195"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-antagonist/killer 1 HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation References_end </body> </html> </notes> <label text="IDH3C"/> <bbox w="80.0" h="40.0" x="9703.906" y="4890.0"/> </glyph> <glyph class="macromolecule" id="s551_sa5196"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutamate ionotropic receptor NMDA type subunit associated protein 1 HUGO:GRINA hgnc_id:HGNC:4589 HGNC:4589 ENTREZ:2907 UNIPROT:Q7Z429 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Binding of Bax and Bak to IRE1 is negatively regulated by Bax Inhibitor 1 (BI-1), a transmembrane protein localized to the ER and nuclear envelope References_end </body> </html> </notes> <label text="TMBIM3"/> <bbox w="80.0" h="50.0" x="9703.906" y="4935.0"/> <glyph class="state variable" id="_40e398c0-a824-4882-a0b2-c098db483453"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9755.475" y="4930.0"/> </glyph> <glyph class="unit of information" id="_e8431b93-9a59-4a27-9a62-2ef55bd2256d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9721.406" y="4930.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s585_csa520" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HSP70*:IRE1-alpha* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="IRE1*:HSPA1A"/> <bbox w="100.0" h="150.0" x="8240.0" y="4005.0"/> <glyph class="macromolecule" id="s586_sa5197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 heat shock 70kDa protein 1B HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 heat shock 70kDa protein 1-like HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="8250.0" y="4095.0"/> </glyph> <glyph class="macromolecule" id="s587_sa5198"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="70.0" x="8250.0" y="4020.0"/> <glyph class="state variable" id="_4fdf2ab6-de41-4afe-a056-54332c1b343b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8301.568" y="4015.0"/> </glyph> <glyph class="unit of information" id="_def5cede-0493-41a6-ad8b-43502abc849c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8267.5" y="4015.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s7545_csa522" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BBC3:IRE1-alpha* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1*:BBC3"/> <bbox w="100.0" h="150.0" x="8120.0" y="4075.0"/> <glyph class="macromolecule" id="s573_sa5201"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="8130.0" y="4165.0"/> </glyph> <glyph class="macromolecule" id="s7546_sa5202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="70.0" x="8130.0" y="4090.0"/> <glyph class="state variable" id="_49248489-34ef-46ac-9a5f-3361b4277603"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8181.5684" y="4085.0"/> </glyph> <glyph class="unit of information" id="_81bf22ca-d8ad-428e-991a-48c1a1e0d0a8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8147.5" y="4085.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s619_csa523" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BiP*:Ca2+:Grp75*:ITPR*:SIGMAR1:VDAC* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="s619"/> <bbox w="240.0" h="205.0" x="8260.0" y="4927.5"/> <glyph class="simple chemical" id="s7618_sa4802"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end </body> </html> </notes> <label text="Ca2+"/> <bbox w="32.5" h="32.5" x="8416.016" y="5048.75"/> </glyph> <glyph class="macromolecule" id="s616_sa5203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 9 HUGO:HSPA9 hgnc_id:HGNC:5244 HGNC:5244 ENTREZ:3313 UNIPROT:P38646 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="Grp75*"/> <bbox w="80.0" h="40.0" x="8280.0" y="5000.0"/> </glyph> <glyph class="macromolecule" id="s620_sa5204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sigma non-opioid intracellular receptor 1 HUGO:SIGMAR1 hgnc_id:HGNC:8157 HGNC:8157 ENTREZ:10280 UNIPROT:Q99720 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: SIGMAR1 PMID:23430059 References_end </body> </html> </notes> <label text="SIGMAR1"/> <bbox w="80.0" h="50.0" x="8400.0" y="4987.5"/> <glyph class="unit of information" id="_6aed3152-166d-4ce2-b9a5-2bc8d8b4d1a9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8417.5" y="4982.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s622_sa5205"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <bbox w="80.0" h="40.0" x="8400.0" y="4942.5"/> </glyph> <glyph class="macromolecule" id="s697_sa5206"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 1 HUGO:ITPR1 hgnc_id:HGNC:6180 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 inositol 1,4,5-trisphosphate receptor type 2 HUGO:ITPR2 hgnc_id:HGNC:6181 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 inositol 1,4,5-trisphosphate receptor type 3 HUGO:ITPR3 hgnc_id:HGNC:6182 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ITPR*"/> <bbox w="80.0" h="50.0" x="8280.0" y="4945.0"/> <glyph class="unit of information" id="_f7cb7cd1-3130-4b99-8bd6-06bfed5eaf1d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8297.5" y="4940.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s707_sa5207"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <bbox w="80.0" h="40.0" x="8280.0" y="5050.0"/> </glyph> </glyph> <glyph class="complex" id="s625_csa524" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BiP*:SIGMAR1 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BiP*:SIGMAR1"/> <bbox w="100.0" h="130.0" x="8540.0" y="4885.0"/> <glyph class="macromolecule" id="s623_sa5208"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sigma non-opioid intracellular receptor 1 HUGO:SIGMAR1 hgnc_id:HGNC:8157 HGNC:8157 ENTREZ:10280 UNIPROT:Q99720 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: SIGMAR1 PMID:23430059 References_end </body> </html> </notes> <label text="SIGMAR1"/> <bbox w="80.0" h="50.0" x="8550.0" y="4940.0"/> <glyph class="unit of information" id="_2e8f46e2-b518-4f5c-8c31-fc2cded9e81e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8567.5" y="4935.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s626_sa5209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <bbox w="80.0" h="40.0" x="8550.0" y="4890.0"/> </glyph> </glyph> <glyph class="complex" id="s702_csa525" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SEC61A1:SEC61A2:SEC61B:SEC61G Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: Complex PMID:19509052 References_end </body> </html> </notes> <label text="Sec61 Complex"/> <bbox w="180.0" h="110.0" x="8990.0" y="5135.0"/> <glyph class="macromolecule" id="s701_sa5210"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Sec61 translocon gamma subunit HUGO:SEC61G hgnc_id:HGNC:18277 HGNC:18277 ENTREZ:23480 UNIPROT:P60059 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="SEC61G"/> <bbox w="80.0" h="40.0" x="9080.0" y="5185.0"/> </glyph> <glyph class="macromolecule" id="s700_sa5211"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Sec61 translocon beta subunit HUGO:SEC61B hgnc_id:HGNC:16993 HGNC:16993 ENTREZ:10952 UNIPROT:P60468 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="SEC61B"/> <bbox w="80.0" h="40.0" x="9080.0" y="5145.0"/> </glyph> <glyph class="macromolecule" id="s699_sa5212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Sec61 translocon alpha 2 subunit HUGO:SEC61A2 hgnc_id:HGNC:17702 HGNC:17702 ENTREZ:55176 UNIPROT:Q9H9S3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="SEC61A2"/> <bbox w="80.0" h="40.0" x="9000.0" y="5185.0"/> </glyph> <glyph class="macromolecule" id="s698_sa5213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Sec61 translocon alpha 1 subunit HUGO:SEC61A1 hgnc_id:HGNC:18276 HGNC:18276 ENTREZ:29927 UNIPROT:P61619 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="SEC61A1"/> <bbox w="80.0" h="40.0" x="9000.0" y="5145.0"/> </glyph> </glyph> <glyph class="complex" id="s7547_csa526" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATP5S:Ca2+ Identifiers_end </body> </html> </notes> <label text="CAPN1:Ca2+"/> <bbox w="100.0" h="110.0" x="8610.0" y="3835.0"/> <glyph class="macromolecule" id="s723_sa5214"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PORPHYRIN_METABOLISM MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19931333 synonym:Calpain 1 synonym:mu-calpain References_end </body> </html> </notes> <label text="ATP5S"/> <bbox w="80.0" h="40.0" x="8620.0" y="3845.0"/> </glyph> <glyph class="simple chemical" id="s7578_sa5215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:29108 MODULE:ER_STRESS PMID:23850759 </body> </html> </notes> <label text="Ca2+"/> <bbox w="32.5" h="32.5" x="8643.75" y="3893.75"/> </glyph> </glyph> <glyph class="complex" id="s7573_csa517" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CHUK:IKBKG:SDHC Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: kinase PMID:23430059 References_end </body> </html> </notes> <label text="IkB kinase (IKK)"/> <bbox w="100.0" h="150.0" x="9890.0" y="5115.0"/> <glyph class="macromolecule" id="s7574_sa5190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: conserved helix-loop-helix ubiquitous kinase HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 IKBK-alpha synonym:IKBKA synonym:IKK_alpha_ Maps_Modules_end References_end </body> </html> </notes> <label text="CHUK"/> <bbox w="80.0" h="40.0" x="9900.0" y="5125.0"/> </glyph> <glyph class="macromolecule" id="s534_sa5191"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of nuclear factor kappa B kinase subunit beta HUGO:IKBKB hgnc_id:HGNC:5960 HGNC:5960 ENTREZ:3551 UNIPROT:O14920 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="SDHC"/> <bbox w="80.0" h="40.0" x="9900.0" y="5165.0"/> <glyph class="state variable" id="_929aceb9-6aef-4788-add7-140888e14375"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9972.5" y="5180.0"/> </glyph> <glyph class="state variable" id="_84092b9c-234c-49d0-9bd0-558d19451c90"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9892.5" y="5180.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s516_sa5192"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 NEMO References_end </body> </html> </notes> <label text="IKBKG"/> <bbox w="80.0" h="40.0" x="9900.0" y="5205.0"/> </glyph> </glyph> <glyph class="complex" id="s7575_csa521" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:IRE1-alpha* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="IRE1*:Bim*"/> <bbox w="100.0" h="150.0" x="8110.0" y="4255.0"/> <glyph class="macromolecule" id="s7576_sa5199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="8120.0" y="4350.0"/> <glyph class="state variable" id="_49f49988-8436-422b-a093-84fb95c55e1d"> <state value="" variable="T56"/> <bbox w="25.0" h="10.0" x="8147.5317" y="4345.0"/> </glyph> <glyph class="state variable" id="_95903355-96e6-4a5a-af37-4f95b6c1c14e"> <state value="" variable="S58"/> <bbox w="25.0" h="10.0" x="8187.5" y="4345.215"/> </glyph> <glyph class="state variable" id="_861566db-c93a-4386-891c-48abb29b3070"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8171.7993" y="4385.0"/> </glyph> <glyph class="state variable" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FAS_RESPONSE MODULE:GLUTAMINE_METABOLISM MODULE:NECROPTOSIS MODULE:TNF_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 PMID:19632174 RIP kinases at the crossroads of cell death and survival PMID:19524513 PMID:28574505 PMID:23010170 PMID:26653790 erastin-induced cell death proceeds normally on knockdown of RIPK1/RIPK3 References_end </body> </html> </notes> <label text="RIPK1"/> <bbox w="80.0" h="40.0" x="8390.0" y="4540.0"/> <glyph class="state variable" id="_b360b924-fb70-45f5-8446-609947a2f5e5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8385.0" y="4546.1714"/> </glyph> <glyph class="state variable" id="_2a08a10a-e722-4c0f-af93-273d767504b6"> <state value="" variable="K377"/> <bbox w="30.0" h="10.0" x="8455.0" y="4546.25"/> </glyph> <glyph class="state variable" id="_a0311f70-7950-4579-bf27-98d056bafa38"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8427.837" y="4535.0"/> </glyph> <glyph class="state variable" id="_88df8539-bf19-418e-82b1-e610db03ea31"> <state value="" variable="S161"/> <bbox w="30.0" h="10.0" x="8431.331" y="4575.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7628_sa4972" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transmembrane BAX inhibitor motif containing 6 HUGO:TMBIM6 HGNC:11723 ENTREZ:7009 UNIPROT:P55061 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="TMBIM6"/> <bbox w="80.0" h="50.0" x="8600.0" y="4035.0"/> <glyph class="unit of information" id="_4a9afba3-7b43-4e3e-a358-7aa8924d896d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8617.5" y="4030.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7630_sa4720" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <clone/> <bbox w="90.0" h="25.0" x="8490.703" y="7090.5"/> <glyph class="unit of information" id="_07fc8171-7606-4dcd-9732-d4c6a9d55d20"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8525.703" y="7085.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7630_sa4721" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <clone/> <bbox w="90.0" h="25.0" x="8610.703" y="7090.5"/> <glyph class="unit of information" id="_a5f8ac2f-e9f9-4e66-8160-b53aed759051"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8645.703" y="7085.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7631_sa4731" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA damage inducible transcript 3 HUGO:DDIT3 hgnc_id:HGNC:2726 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 References_end </body> </html> </notes> <label text="CHOP*"/> <clone/> <bbox w="80.0" h="40.0" x="8947.734" y="7381.875"/> <glyph class="state variable" id="_f0167a93-3544-41fe-ac29-0c49188cb4d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8999.303" y="7376.875"/> </glyph> </glyph> <glyph class="macromolecule" id="s7631_sa4753" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: DNA damage inducible transcript 3 HUGO:DDIT3 hgnc_id:HGNC:2726 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 References_end </body> </html> </notes> <label text="CHOP*"/> <clone/> <bbox w="80.0" h="40.0" x="9282.266" y="7405.0"/> <glyph class="state variable" id="_d9deec35-2014-4807-a7c0-0156db9b0f73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9333.834" y="7400.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7632_sa4749" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 6 HUGO:ATF6 hgnc_id:HGNC:791 HGNC:791 ENTREZ:22926 UNIPROT:P18850 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 ATF6 respond to fluctuations in the ratio of free BiP that are caused by alterations in ER load or the accumulation of unfolded proteins PMID:26587781 PMID:17991856 PMID:18360008 References_end </body> </html> </notes> <label text="ATF6"/> <bbox w="80.0" h="40.0" x="9972.266" y="7515.0"/> <glyph class="unit of information" id="_ee1ce68e-c20a-4036-a3b0-208b3050e498"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9989.766" y="7510.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7633_sa4830" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: microRNA 221 HUGO:MIR221 HGNC:31601 ENTREZ:407006 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23138871 References_end </body> </html> </notes> <label text="MIR221"/> <bbox w="90.0" h="25.0" x="9927.266" y="7292.5"/> <glyph class="unit of information" id="_2c68bf0e-9d85-4f02-89a0-37ddc205367e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="9957.266" y="7287.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7634_sa4852" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Jun proto-oncogene, AP-1 transcription factor subunit HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26587781 References_end </body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="9032.266" y="7305.0"/> <glyph class="state variable" id="_7b01d2c4-0621-47de-9b0b-408acbd3f06c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9083.834" y="7300.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7635_sa4869" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Jun proto-oncogene, AP-1 transcription factor subunit HUGO:JUN hgnc_id:HGNC:6204 HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Fos proto-oncogene, AP-1 transcription factor subunit HUGO:FOS hgnc_id:HGNC:3796 HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:26618107 References_end </body> </html> </notes> <label text="AP-1*"/> <bbox w="80.0" h="40.0" x="9526.797" y="7378.125"/> <glyph class="state variable" id="_a6c854b8-d060-4295-91c6-a094e06ccefc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9599.297" y="7401.409"/> </glyph> <glyph class="state variable" id="_ce39efcd-a9fc-4473-87c2-d5fb21d39ece"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9599.297" y="7384.841"/> </glyph> </glyph> <glyph class="macromolecule" id="s7636_sa4885" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 3 HUGO:ATF3 hgnc_id:HGNC:785 HGNC:785 ENTREZ:467 UNIPROT:P18847 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF3"/> <bbox w="80.0" h="40.0" x="10542.266" y="7455.0"/> </glyph> <glyph class="macromolecule" id="s7637_sa4886" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 4 HUGO:ATF4 hgnc_id:HGNC:786 HGNC:786 ENTREZ:468 UNIPROT:P18848 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ATF4"/> <bbox w="80.0" h="40.0" x="10542.266" y="7505.0"/> </glyph> <glyph class="simple chemical" id="s7638_sa4887" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: Eeyarestatin I, EerI PMID:19164757 References_end </body> </html> </notes> <label text="Eeyarestatin I"/> <bbox w="80.0" h="30.0" x="10592.266" y="7390.0"/> <glyph class="unit of information" id="_b63ef4a5-d039-4afe-9dec-db7470f30f4a"> <label text="drug"/> <bbox w="25.0" h="10.0" x="10619.766" y="7385.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7639_sa4889" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: histone cluster 2, H2ac HUGO:HIST2H2AC HGNC:4738 ENTREZ:8338 UNIPROT:Q16777 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="H2A*"/> <clone/> <bbox w="80.0" h="40.0" x="10562.266" y="7315.0"/> </glyph> <glyph class="macromolecule" id="s7639_sa4890" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: histone cluster 2, H2ac HUGO:HIST2H2AC HGNC:4738 ENTREZ:8338 UNIPROT:Q16777 Identifiers_end Maps_Modules_begin: MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="H2A*"/> <clone/> <bbox w="80.0" h="40.0" x="10722.266" y="7315.0"/> </glyph> <glyph class="macromolecule" id="s7640_sa4948" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor kappa B subunit 2 HUGO:NFKB2 hgnc_id:HGNC:7795 HGNC:7795 ENTREZ:4791 UNIPROT:Q00653 RELA proto-oncogene, NF-kB subunit HUGO:RELA hgnc_id:HGNC:9955 HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 RELB proto-oncogene, NF-kB subunit HUGO:RELB hgnc_id:HGNC:9956 HGNC:9956 ENTREZ:5971 UNIPROT:Q01201 nuclear factor kappa B subunit 1 HUGO:NFKB1 hgnc_id:HGNC:7794 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 REL proto-oncogene, NF-kB subunit HUGO:REL hgnc_id:HGNC:9954 HGNC:9954 ENTREZ:5966 UNIPROT:Q04864 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="NFKB*"/> <bbox w="80.0" h="40.0" x="8132.2656" y="7315.0"/> </glyph> <glyph class="macromolecule" id="s7641_sa4706" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:26587781 PMID:23430059 Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity References_end </body> </html> </notes> <label text="IRE1-alpha*"/> <bbox w="80.0" h="70.0" x="9033.906" y="4935.0"/> <glyph class="state variable" id="_2c6c5b55-6ccb-4ed6-9d8f-af82228fc0f3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9085.475" y="4930.0"/> </glyph> <glyph class="unit of information" id="_a838162c-1211-47b1-9f6d-ec6c291300ec"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9051.406" y="4930.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7642_sa4708" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 6 HUGO:ATF6 hgnc_id:HGNC:791 HGNC:791 ENTREZ:22926 UNIPROT:P18850 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 ATF6 respond to fluctuations in the ratio of free BiP that are caused by alterations in ER load or the accumulation of unfolded proteins PMID:26587781 PMID:17991856 PMID:18360008 References_end </body> </html> </notes> <label text="ATF6"/> <bbox w="80.0" h="40.0" x="10888.281" y="4935.0"/> <glyph class="unit of information" id="_d798497b-d10d-4101-a641-b9dc275904c9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10905.781" y="4930.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7643_sa4709" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <clone/> <bbox w="80.0" h="40.0" x="10983.906" y="4850.0"/> </glyph> <glyph class="macromolecule" id="s7643_sa4711" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <clone/> <bbox w="80.0" h="40.0" x="10483.906" y="4870.0"/> </glyph> <glyph class="macromolecule" id="s7643_sa4839" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <clone/> <bbox w="80.0" h="40.0" x="8973.906" y="4830.0"/> </glyph> <glyph class="macromolecule" id="s7643_sa4989" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: heat shock protein family A (Hsp70) member 5 HUGO:HSPA5 hgnc_id:HGNC:5238 HGNC:5238 ENTREZ:3309 UNIPROT:P11021 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 GRP78 References_end </body> </html> </notes> <label text="BiP*"/> <clone/> <bbox w="80.0" h="40.0" x="9040.0" y="4510.0"/> </glyph> <glyph class="macromolecule" id="s7644_sa4710" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <clone/> <bbox w="160.0" h="30.0" x="10233.906" y="4420.0"/> <glyph class="state variable" id="_ed12f157-e585-43ad-8fdd-12eb685207f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10285.695" y="4445.0"/> </glyph> <glyph class="state variable" id="_553eefc8-5034-4f26-aeac-0a65e0e92385"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10228.906" y="4423.7866"/> </glyph> <glyph class="state variable" id="_aa64e82f-fd55-49e4-a376-82a351a2d256"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="10343.167" y="4415.0"/> </glyph> <glyph class="unit of information" id="_4f11e97c-3cf5-4a7f-858b-5c03cb23acdc"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10288.906" y="4415.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7644_sa4840" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <clone/> <bbox w="160.0" h="30.0" x="9053.906" y="4745.0"/> <glyph class="state variable" id="_59dbbac8-ad36-4e1a-9a16-480de05795a9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9105.695" y="4770.0"/> </glyph> <glyph class="state variable" id="_8387c63a-16ad-4292-8b3b-74959190b1ef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9048.906" y="4748.7866"/> </glyph> <glyph class="state variable" id="_a4ecee4d-f677-4327-8d49-1d4f92075734"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="9163.167" y="4740.0"/> </glyph> <glyph class="unit of information" id="_b04d0850-c6e5-43e6-9e45-591b049e82b1"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9108.906" y="4740.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7644_sa4906" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <clone/> <bbox w="160.0" h="30.0" x="11250.0" y="4785.0"/> <glyph class="state variable" id="_6f82d27a-6605-4cdd-8e65-083348f4a3c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11301.789" y="4810.0"/> </glyph> <glyph class="state variable" id="_107e6b7c-38c8-4673-b040-da7a6ae45e67"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11245.0" y="4788.7866"/> </glyph> <glyph class="state variable" id="_5b56c096-31f4-4cfa-897e-8491066674bc"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="11359.261" y="4780.0"/> </glyph> <glyph class="unit of information" id="_5f38bb4b-2d55-4838-b2c5-6d7fbd8625bf"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11305.0" y="4780.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7644_sa4930" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <clone/> <bbox w="160.0" h="30.0" x="8673.906" y="4745.0"/> <glyph class="state variable" id="_98e1f7ca-5713-4e59-a892-9f478ae14ae9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8725.695" y="4770.0"/> </glyph> <glyph class="state variable" id="_42f8755f-0361-48f6-8734-6494631f3bb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8668.906" y="4748.7866"/> </glyph> <glyph class="state variable" id="_cd5b7c6c-19d9-414b-9b7b-945e09ae7f42"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="8783.167" y="4740.0"/> </glyph> <glyph class="unit of information" id="_494fa3d4-5f18-44ac-b38b-696469a4fdc3"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8728.906" y="4740.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7645_sa4797" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="32.5" h="32.5" x="9669.844" y="4123.75"/> </glyph> <glyph class="simple chemical" id="s7645_sa4819" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="32.5" h="32.5" x="8729.844" y="4103.75"/> </glyph> <glyph class="simple chemical" id="s7645_sa4974" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="32.5" h="32.5" x="9769.844" y="4123.75"/> </glyph> <glyph class="simple chemical" id="s7645_sa5540" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end </body> </html> </notes> <label text="Ca2+"/> <clone/> <bbox w="32.5" h="32.5" x="8465.5" y="4853.0"/> </glyph> <glyph class="phenotype" id="s7646_sa4807" compartmentRef="c36_ca38"> <label text="Protein folding"/> <clone/> <bbox w="110.0" h="35.0" x="10678.906" y="4542.5"/> </glyph> <glyph class="phenotype" id="s7646_sa4933" compartmentRef="c36_ca38"> <label text="Protein folding"/> <clone/> <bbox w="110.0" h="35.0" x="8698.906" y="4512.5"/> </glyph> <glyph class="macromolecule" id="s7647_sa4816" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2"/> <bbox w="80.0" h="40.0" x="9853.906" y="4700.0"/> <glyph class="state variable" id="_269346b3-0779-4eca-bed5-5505d7743a17"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9872.338" y="4695.0"/> </glyph> <glyph class="state variable" id="_f9ad6ede-df86-41b2-ba06-d68914aa152e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9905.475" y="4695.0"/> </glyph> <glyph class="state variable" id="_bee54b13-44b7-4eaf-b4a1-18ada78933f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9848.906" y="4715.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7648_sa4817" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="9983.906" y="4940.0"/> </glyph> <glyph class="macromolecule" id="s7649_sa4824" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <clone/> <bbox w="80.0" h="40.0" x="10223.906" y="4520.0"/> <glyph class="state variable" id="_20e51c2f-101e-4d55-9b0b-bf52997c654b"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="10224.983" y="4515.0"/> </glyph> <glyph class="state variable" id="_6db2dab1-d2ed-4ad7-875f-fc2037bfab19"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="10269.99" y="4515.0"/> </glyph> <glyph class="state variable" id="_b6e4901c-4bbc-4b45-95fe-10b72dc51305"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="10270.228" y="4555.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7649_sa4958" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation PMID:23377657 References_end </body> </html> </notes> <label text="BAX"/> <clone/> <bbox w="80.0" h="40.0" x="9473.906" y="4770.0"/> <glyph class="state variable" id="_34043558-7cc4-492b-b8c4-3c391d1c85a6"> <state value="" variable="T167"/> <bbox w="30.0" h="10.0" x="9474.983" y="4765.0"/> </glyph> <glyph class="state variable" id="_83ddcea8-b252-4b85-80f4-f555baf98c76"> <state value="" variable="S163"/> <bbox w="30.0" h="10.0" x="9519.99" y="4765.0"/> </glyph> <glyph class="state variable" id="_b9793380-6690-47b8-8a20-b1118c5d33cd"> <state value="" variable="S184"/> <bbox w="30.0" h="10.0" x="9520.228" y="4805.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7650_sa4905" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="11510.0" y="4785.0"/> <glyph class="state variable" id="_3a86be52-4a79-408d-9b17-c16bb6643280"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11561.789" y="4810.0"/> </glyph> <glyph class="state variable" id="_ad5a213a-2a5b-48b7-8886-8ec236634095"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11500.0" y="4788.7866"/> </glyph> <glyph class="state variable" id="_5fe64b5d-4be4-4b65-acf6-0801771517d2"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="11619.261" y="4780.0"/> </glyph> <glyph class="unit of information" id="_fb66b901-53e0-462c-acda-f44ff0733dc3"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11565.0" y="4780.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7651_sa4908" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end </body> </html> </notes> <label text="ATP"/> <bbox w="70.0" h="25.0" x="11658.906" y="4737.5"/> </glyph> <glyph class="macromolecule" id="s7652_sa4909" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="p97*"/> <clone/> <bbox w="80.0" h="40.0" x="11160.0" y="4580.0"/> </glyph> <glyph class="macromolecule" id="s7652_sa4924" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: valosin containing protein HUGO:VCP hgnc_id:HGNC:12666 HGNC:12666 ENTREZ:7415 UNIPROT:P55072 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:12847084 PMID:19509052 PMID:16186509 References_end </body> </html> </notes> <label text="p97*"/> <clone/> <bbox w="80.0" h="40.0" x="11490.0" y="4150.0"/> </glyph> <glyph class="simple chemical" id="s7653_sa4914" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: Eeyarestatin I, EerI PMID:19164757 References_end </body> </html> </notes> <label text="Eeyarestatin I"/> <bbox w="80.0" h="30.0" x="11199.0" y="4347.0"/> <glyph class="unit of information" id="_515b3529-4d8f-442e-bc79-c63a884b44ac"> <label text="drug"/> <bbox w="25.0" h="10.0" x="11226.5" y="4342.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7654_sa4926" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: homocysteine inducible ER protein with ubiquitin like domain 1 HUGO:HERPUD1 hgnc_id:HGNC:13744 HGNC:13744 ENTREZ:9709 UNIPROT:Q15011 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 References_end </body> </html> </notes> <label text="HERP*"/> <bbox w="80.0" h="40.0" x="11640.0" y="4130.0"/> </glyph> <glyph class="macromolecule" id="s7655_sa4935" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SEL1L ERAD E3 ligase adaptor subunit HUGO:SEL1L hgnc_id:HGNC:10717 HGNC:10717 ENTREZ:6400 UNIPROT:Q9UBV2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:16186509 References_end </body> </html> </notes> <label text="SEL1L"/> <bbox w="80.0" h="40.0" x="11415.0" y="4340.0"/> </glyph> <glyph class="macromolecule" id="s7656_sa4939" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <clone/> <bbox w="80.0" h="40.0" x="9853.906" y="4630.0"/> </glyph> <glyph class="macromolecule" id="s7656_sa4940" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <clone/> <bbox w="80.0" h="40.0" x="9703.906" y="4630.0"/> </glyph> <glyph class="macromolecule" id="s7657_sa4963" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:23430059 synonym:BIM References_end </body> </html> </notes> <label text="BCL2L11"/> <bbox w="80.0" h="40.0" x="8280.0" y="4340.0"/> <glyph class="state variable" 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MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 synonym:PUMA References_end </body> </html> </notes> <label text="BBC3"/> <bbox w="80.0" h="40.0" x="8420.0" y="4400.0"/> </glyph> <glyph class="macromolecule" id="s7659_sa4965" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 1A HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 heat shock 70kDa protein 1B HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 heat shock 70kDa protein 1-like HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:RCD_GENES MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="8560.0" y="4400.0"/> </glyph> <glyph class="macromolecule" id="s7660_sa4976" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 HUGO:ATP2A2 hgnc_id:HGNC:812 HGNC:812 ENTREZ:488 UNIPROT:P16615 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 PMID:18360008 PMID:28747251 SERCA2 PMID:28747251 PMID:27157108 References_end </body> </html> </notes> <label text="ATP2A2"/> <bbox w="80.0" h="40.0" x="10216.094" y="4040.0"/> </glyph> <glyph class="macromolecule" id="s7667_sa4815" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transmembrane BAX inhibitor motif containing 6 HUGO:TMBIM6 HGNC:11723 ENTREZ:7009 UNIPROT:P55061 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="TMBIM6"/> <bbox w="80.0" h="50.0" x="8340.0" y="4795.0"/> <glyph class="unit of information" id="_dbc45579-4127-40a2-904e-c55c2feb2618"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8357.5" y="4790.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7668_sa5061" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <bbox w="80.0" h="40.0" x="8300.0" y="5240.0"/> </glyph> <glyph class="macromolecule" id="s7669_sa4803" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: cytochrome c, somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 synonym:cytochrome_c References_end </body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="8130.0" y="5420.0"/> </glyph> <glyph class="simple chemical" id="s7670_sa4806" compartmentRef="c37_ca39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29108 KEGGCOMPOUND:C00076 CAS:14127-61-8 Identifiers_end </body> </html> </notes> <label text="Ca2+"/> <bbox w="32.5" h="32.5" x="8443.75" y="5283.75"/> </glyph> <glyph class="macromolecule" id="s7673_sa5056" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 1 HUGO:ITPR1 hgnc_id:HGNC:6180 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 inositol 1,4,5-trisphosphate receptor type 2 HUGO:ITPR2 hgnc_id:HGNC:6181 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 inositol 1,4,5-trisphosphate receptor type 3 HUGO:ITPR3 hgnc_id:HGNC:6182 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ITPR*"/> <clone/> <bbox w="80.0" h="50.0" x="8906.094" y="4035.0"/> <glyph class="unit of information" id="_ad810a2e-cbdf-4383-bd57-88d15315fc03"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8923.594" y="4030.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7673_sa5057" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 1 HUGO:ITPR1 hgnc_id:HGNC:6180 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 inositol 1,4,5-trisphosphate receptor type 2 HUGO:ITPR2 hgnc_id:HGNC:6181 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 inositol 1,4,5-trisphosphate receptor type 3 HUGO:ITPR3 hgnc_id:HGNC:6182 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ITPR*"/> <clone/> <bbox w="80.0" h="50.0" x="8776.094" y="4035.0"/> <glyph class="unit of information" id="_16cb7f6d-b24e-41e2-96df-1c1399e67d00"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8793.594" y="4030.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7674_sa4925" compartmentRef="c36_ca38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: synoviolin 1 HUGO:SYVN1 hgnc_id:HGNC:20738 HGNC:20738 ENTREZ:84447 UNIPROT:Q86TM6 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:19509052 PMID:18360008 HRD1 References_end </body> </html> </notes> <label text="SYVN1"/> <bbox w="80.0" h="40.0" x="11460.0" y="4430.0"/> </glyph> <glyph class="macromolecule" id="s7676_sa4743" compartmentRef="c39_ca41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 6 HUGO:ATF6 hgnc_id:HGNC:791 HGNC:791 ENTREZ:22926 UNIPROT:P18850 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 ATF6 respond to fluctuations in the ratio of free BiP that are caused by alterations in ER load or the accumulation of unfolded proteins PMID:26587781 PMID:17991856 PMID:18360008 References_end </body> </html> </notes> <label text="ATF6"/> <clone/> <bbox w="80.0" h="40.0" x="10973.75" y="6415.0"/> <glyph class="unit of information" id="_1f79c15b-9957-4ca7-972c-12c2e4aeb617"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10991.25" y="6410.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7676_sa4747" compartmentRef="c39_ca41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 6 HUGO:ATF6 hgnc_id:HGNC:791 HGNC:791 ENTREZ:22926 UNIPROT:P18850 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 ATF6 respond to fluctuations in the ratio of free BiP that are caused by alterations in ER load or the accumulation of unfolded proteins PMID:26587781 PMID:17991856 PMID:18360008 References_end </body> </html> </notes> <label text="ATF6"/> <clone/> <bbox w="80.0" h="40.0" x="10973.75" y="6505.0"/> <glyph class="unit of information" id="_4f63468d-e8e4-4743-8971-409b8445a681"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10991.25" y="6500.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7676_sa4748" compartmentRef="c39_ca41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: activating transcription factor 6 HUGO:ATF6 hgnc_id:HGNC:791 HGNC:791 ENTREZ:22926 UNIPROT:P18850 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 ATF6 respond to fluctuations in the ratio of free BiP that are caused by alterations in ER load or the accumulation of unfolded proteins PMID:26587781 PMID:17991856 PMID:18360008 References_end </body> </html> </notes> <label text="ATF6"/> <clone/> <bbox w="80.0" h="40.0" x="10973.75" y="6605.0"/> <glyph class="unit of information" id="_aa953949-86a7-40be-8768-3c11d413e8bf"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10991.25" y="6600.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7677_sa4863" compartmentRef="c40_ca42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: autophagy related 5 HUGO:ATG5 HGNC:589 ENTREZ:9474 UNIPROT:Q9H1Y0 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23725295 References_end </body> </html> </notes> <label text="ATG5"/> <bbox w="80.0" h="40.0" x="11195.0" y="5780.0"/> </glyph> <glyph class="macromolecule" id="s7678_sa4916" compartmentRef="c41_ca43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="11540.0" y="5325.0"/> <glyph class="state variable" id="_461c7605-22e3-4d04-a8df-dd5ca859f73d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11591.789" y="5350.0"/> </glyph> <glyph class="state variable" id="_7499f72c-fc47-4b5d-8931-815387d17a31"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11530.0" y="5328.7866"/> </glyph> <glyph class="state variable" id="_81a26ba3-300d-4cbf-8f93-dd827e8d33ac"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="11649.261" y="5320.0"/> </glyph> <glyph class="unit of information" id="_acd3dd8d-c405-47d1-af6f-303c9a78c967"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11595.0" y="5320.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7679_sa4917" compartmentRef="c41_ca43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 PMID:12847084 PMID:19509052 Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation References_end </body> </html> </notes> <label text="Unfolded protein*"/> <bbox w="160.0" h="30.0" x="11390.0" y="5430.0"/> <glyph class="state variable" id="_5ead7429-cdc5-430f-a1a8-a9ffcba56434"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11441.789" y="5455.0"/> </glyph> <glyph class="state variable" id="_2b20034a-d7a7-479e-a38b-1b814f639e10"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11385.0" y="5433.7866"/> </glyph> <glyph class="state variable" id="_375d8b3f-7b76-4da3-850b-59c32af12d1a"> <state value="" variable="disulphide bond"/> <bbox w="85.0" h="10.0" x="11499.261" y="5425.0"/> </glyph> <glyph class="unit of information" id="_57343b11-782f-450e-a960-04eb7429c32f"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11445.0" y="5425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7689_sa5216" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="2060.0" y="7810.0"/> <glyph class="state variable" id="_01a2d5f7-a514-419a-986a-be408d4d1536"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2096.438" y="7805.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7690_sa5217" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: poly(ADP-ribose) polymer PMID:24684389 References_end </body> </html> </notes> <label text="PAR Polymer"/> <bbox w="95.0" h="32.5" x="2085.0" y="7927.5"/> </glyph> <glyph class="macromolecule" id="s7692_sa5219" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="1960.0" y="6340.0"/> <glyph class="state variable" id="_9dc9081c-c109-43f4-876a-3e3b6c0649f7"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="1993.938" y="6335.0"/> </glyph> </glyph> <glyph class="complex" id="s7693_csa527" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AIFM1:PAR Polymer Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:24684389 References_end </body> </html> </notes> <label text="AIFM1:PAR Polymer"/> <bbox w="100.0" h="115.0" x="2250.0" y="7765.0"/> <glyph class="simple chemical" id="s7694_sa5220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: poly(ADP-ribose) polymer PMID:24684389 References_end </body> </html> </notes> <label text="PAR Polymer"/> <bbox w="95.0" h="32.5" x="2252.5" y="7818.75"/> </glyph> <glyph class="macromolecule" id="s7695_sa5221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:PCD_GENES Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: apoptosis-inducing factor, mitochondrion-associated, 1 HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:RCD_GENES MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: synonym:AIF NOTE: * means carbonylated PMID:24684389 There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side) References_end </body> </html> </notes> <label text="AIFM1"/> <bbox w="80.0" h="40.0" x="2257.5" y="7781.25"/> <glyph class="state variable" id="_53e4cc72-02e0-43b5-a130-8408b577da7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2293.938" y="7776.25"/> </glyph> </glyph> </glyph> <glyph class="phenotype" id="s7696_sa5222" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:24684389 References_end </body> </html> </notes> <label text="Chromatin condensation"/> <bbox w="170.0" h="35.0" x="2215.0" y="7942.5"/> </glyph> <glyph class="simple chemical" id="s7697_sa5224" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:72080 Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="Phosphatidylserine"/> <bbox w="145.0" h="32.5" x="2027.5" y="8183.75"/> </glyph> <glyph class="simple chemical" id="s7699_sa5225" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:26523 Identifiers_end </body> </html> </notes> <label text="ROS"/> <bbox w="70.0" h="25.0" x="1755.0" y="7517.5"/> </glyph> <glyph class="simple chemical" id="s7700_sa5226" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 3-aminobenzamide Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="3-AB"/> <bbox w="80.0" h="30.0" x="1740.0" y="7415.0"/> <glyph class="unit of information" id="_d6873097-c2c2-4e0f-832f-ad7a307b8868"> <label text="drug"/> <bbox w="25.0" h="10.0" x="1767.5" y="7410.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7701_sa5227" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="DPQ"/> <bbox w="80.0" h="30.0" x="1640.0" y="7415.0"/> <glyph class="unit of information" id="_8bbb9e13-51dc-4b15-bfc1-fe71a25f2cdd"> <label text="drug"/> <bbox w="25.0" h="10.0" x="1667.5" y="7410.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7702_sa5228" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: N-(-oxo-5,6-dihydro-phenanthridin-2-yl)-N,Ndimethylacetamide Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end </body> </html> </notes> <label text="PJ34"/> <bbox w="80.0" h="30.0" x="1540.0" y="7415.0"/> <glyph class="unit of information" id="_e86bec57-ce8f-44e2-80d7-f273a0d5fd6e"> <label text="drug"/> <bbox w="25.0" h="10.0" x="1567.5" y="7410.0"/> </glyph> </glyph> <glyph class="complex" id="s7704_csa528" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARP1:p53* Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_METABOLISM MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:24684389 PMID:27048819Identifiers_end References_end </body> </html> </notes> <label text="p53*:PARP1"/> <bbox w="100.0" h="120.0" x="3000.0" y="7930.0"/> <glyph class="macromolecule" id="s7705_sa5229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1 HGNC:270 ENTREZ:142 UNIPROT:P09874 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:17116881 PMID:24684389 PARP-1 becomes overactivated and produces toxic levels of PAR, which translocates to the cytosol, from where it signals to AIF to effect its nuclear translocation PMID:24976506 References_end </body> </html> </notes> <label text="PARP1"/> <bbox w="80.0" h="40.0" x="3010.0" y="7990.0"/> </glyph> <glyph class="macromolecule" id="s7706_sa5230"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:PCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein p53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:RCD_GENES MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="3010.0" y="7940.0"/> <glyph class="state variable" id="_57fb90c8-8d0b-4104-9fb8-e943aaf89178"> <state value="P" variable="S15"/> <bbox w="30.0" h="10.0" x="3051.9492" y="7935.0"/> </glyph> </glyph> </glyph> <glyph class="phenotype" id="s7707_sa5231" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end References_begin: PMID:23208502 PMID:24582829 References_end </body> </html> </notes> <label text="DNA Repair"/> <bbox w="80.0" h="30.0" x="1590.0" y="7235.0"/> </glyph> <glyph class="phenotype" id="s7708_sa5232" compartmentRef="c13_ca13"> <label text="depletion of NAD+"/> <bbox w="80.0" h="30.0" x="1970.0" y="8015.0"/> </glyph> <glyph class="complex" id="s7713_csa239" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2-XL*:BECN1:UVRAG Identifiers_end References_begin: PMID:23377657 PMID:17446862 References_end </body> </html> </notes> <label text="BCL2-XL*:BECN1:UVRAG"/> <bbox w="189.0" h="121.0" x="9408.5" y="2064.0"/> <glyph class="macromolecule" id="s3195_sa1803"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BCL2-like 1 HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:BCL2-XL References_end </body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="9509.5" y="2073.0"/> </glyph> <glyph class="macromolecule" id="s3194_sa1804"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: beclin 1, autophagy related HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:23377657 PMID:17446862 PMID:27754749 References_end </body> </html> </notes> <label text="BECN1"/> <bbox w="80.0" h="40.0" x="9509.5" y="2117.0"/> <glyph class="state variable" id="_c0448eb9-1af4-4a40-b336-227199805c7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9504.5" y="2112.0"/> </glyph> <glyph class="state variable" id="_f43fbfb1-ca55-405e-adc0-36a2295f3fda"> <state value="" variable="T119"/> <bbox w="30.0" h="10.0" x="9551.449" y="2112.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s6258_sa4419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: UV radiation resistance associated HUGO:UVRAG HGNC:12640 ENTREZ:7405 UNIPROT:Q9P2Y5 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: PMID:17106237 PMID:22885520 PMID:18612260 PMID:23377657 References_end </body> </html> </notes> <label text="UVRAG"/> <bbox w="80.0" h="40.0" x="9421.5" y="2074.0"/> </glyph> </glyph> <glyph class="complex" id="s7714_csa68" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMP:PKA_R*:PRKAA*:PRKAG* Identifiers_end </body> </html> </notes> <label text="AMP:PKA_R*:PRKAA*:PRKAG*"/> <bbox w="176.0" h="112.0" x="8051.0" y="2405.5"/> <glyph class="simple chemical" id="s3060_sa1028"> <label text="AMP"/> <bbox w="70.0" h="25.0" x="8146.0" y="2465.0"/> </glyph> <glyph class="macromolecule" id="s2032_sa1029"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, alpha 1 catalytic subunit HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 protein kinase, AMP-activated, alpha 2 catalytic subunit HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAA*"/> <bbox w="80.0" h="40.0" x="8057.0" y="2411.5"/> <glyph class="state variable" id="_cf9f66b2-763c-4e89-8142-bf2264f18694"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="8098.949" y="2406.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3061_sa1030"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 protein kinase, AMP-activated, beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKA_R*"/> <bbox w="80.0" h="40.0" x="8057.0" y="2455.5"/> </glyph> <glyph class="macromolecule" id="s3062_sa1031"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 protein kinase, AMP-activated, gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 protein kinase, AMP-activated, gamma 3 non-catalytic subunit HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAG*"/> <bbox w="80.0" h="40.0" x="8141.0" y="2411.5"/> </glyph> </glyph> <glyph class="complex" id="s7715_csa69" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATP:PKA_R*:PRKAA*:PRKAG* Identifiers_end </body> </html> </notes> <label text="ATP:PKA_R*:PRKAA*:PRKAG*"/> <bbox w="176.0" h="112.0" x="7803.0" y="2409.5"/> <glyph class="simple chemical" id="s3675_sa1032"> <label text="ATP"/> <bbox w="70.0" h="25.0" x="7900.0" y="2465.0"/> </glyph> <glyph class="macromolecule" id="s3056_sa1033"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, alpha 1 catalytic subunit HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 protein kinase, AMP-activated, alpha 2 catalytic subunit HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAA*"/> <bbox w="80.0" h="40.0" x="7809.0" y="2415.5"/> <glyph class="state variable" id="_f086eee0-aec2-4456-940e-215a673c0dd9"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="7850.949" y="2410.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3057_sa1034"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 protein kinase, AMP-activated, gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 protein kinase, AMP-activated, gamma 3 non-catalytic subunit HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PRKAG*"/> <bbox w="80.0" h="40.0" x="7893.0" y="2415.5"/> </glyph> <glyph class="macromolecule" id="s3058_sa1035"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protein kinase, AMP-activated, beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 protein kinase, AMP-activated, beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM Maps_Modules_end </body> </html> </notes> <label text="PKA_R*"/> <bbox w="80.0" h="40.0" x="7810.0" y="2458.5"/> </glyph> </glyph> <glyph class="complex" id="s7775_csa529" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SLC3A2:SLC7A11 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 References_end </body> </html> </notes> <label text="System xc-"/> <bbox w="180.0" h="90.0" x="8530.0" y="190.0"/> <glyph class="macromolecule" id="s7773_sa5233"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 3 member 2 HUGO:SLC3A2 hgnc_id:HGNC:11026 HGNC:11026 ENTREZ:6520 UNIPROT:P08195 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC3A2"/> <bbox w="80.0" h="50.0" x="8540.0" y="205.0"/> <glyph class="unit of information" id="_a377cd3b-62d0-4c5e-8ba1-241297d32c25"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8557.5" y="200.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7774_sa5234"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 7 member 11 HUGO:SLC7A11 hgnc_id:HGNC:11059 HGNC:11059 ENTREZ:23657 UNIPROT:Q9UPY5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC7A11"/> <bbox w="80.0" h="50.0" x="8620.0" y="205.0"/> <glyph class="unit of information" id="_7be0f37b-4b51-48e2-acd6-1e918ecd99dc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8637.5" y="200.0"/> </glyph> </glyph> </glyph> <glyph class="simple chemical" id="s7779_sa5240" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one Erastin PUBCHEM:11214940 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26653790 PMID:12676586 References_end </body> </html> </notes> <label text="Erastin"/> <bbox w="80.0" h="30.0" x="8960.0" y="110.0"/> <glyph class="unit of information" id="_339e833a-0546-45c1-be47-3079c84f9ccf"> <label text="drug"/> <bbox w="25.0" h="10.0" x="8987.5" y="105.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7780_sa5241" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamideSorafenib PUBCHEM:216239 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Sorafenib"/> <bbox w="80.0" h="30.0" x="8960.0" y="150.0"/> <glyph class="unit of information" id="_b96eabc8-2b42-419f-a160-31f30b1fbe39"> <label text="drug"/> <bbox w="25.0" h="10.0" x="8987.5" y="145.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7781_sa5243" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: (3Z)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acidPUBCHEM:5359476 Sulfasalazine Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Sulfasalazine"/> <bbox w="80.0" h="30.0" x="8600.0" y="115.0"/> <glyph class="unit of information" id="_e6ad24c9-f25a-42ba-8a3b-b0a5dfdff33f"> <label text="drug"/> <bbox w="25.0" h="10.0" x="8627.5" y="110.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s7782_sa5244" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RSL3 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26653790 PMID:26794443 Ferroptosis is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrialmembrane rupture. References_end </body> </html> </notes> <label text="RSL3"/> <bbox w="80.0" h="30.0" x="9420.0" y="625.0"/> <glyph class="unit of information" id="_65d8ea6a-3093-419d-850e-6f74fa68123c"> <label text="drug"/> <bbox w="25.0" h="10.0" x="9447.5" y="620.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7783_sa5297" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione peroxidase 4 HUGO:GPX4 hgnc_id:HGNC:4556 HGNC:4556 ENTREZ:2879 UNIPROT:P36969 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26653790 Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. References_end </body> </html> </notes> <label text="GPX4"/> <bbox w="80.0" h="40.0" x="9660.0" y="820.0"/> </glyph> <glyph class="simple chemical" id="s7791_sa2599" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16856 KEGGCOMPOUND:C00051 CAS:70-18-8 synonyms:gluthatione Identifiers_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="GSH"/> <clone/> <bbox w="70.0" h="25.0" x="9195.0" y="702.5"/> </glyph> <glyph class="simple chemical" id="s7791_sa5384" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16856 KEGGCOMPOUND:C00051 CAS:70-18-8 synonyms:gluthatione Identifiers_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="GSH"/> <clone/> <bbox w="70.0" h="25.0" x="2645.0" y="1597.5"/> </glyph> <glyph class="simple chemical" id="s7792_sa2600" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17858 KEGGCOMPOUND:C00127 CAS:27025-41-8 synonyms:gluthatione Identifiers_end </body> </html> </notes> <label text="GSSG"/> <bbox w="70.0" h="25.0" x="9425.0" y="702.5"/> </glyph> <glyph class="simple chemical" id="s7793_sa5253" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-butyl-DL-homocysteine (S,R)-sulfoximine CHEBI:28714 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="BSO"/> <bbox w="70.0" h="25.0" x="8895.0" y="602.5"/> </glyph> <glyph class="simple chemical" id="s7794_sa5255" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Membrane lipids Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Membrane Lipids*"/> <bbox w="115.0" h="22.5" x="9292.5" y="218.75"/> </glyph> <glyph class="simple chemical" id="s7795_sa5256" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Lipid ROS Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Lipid ROS"/> <bbox w="70.0" h="25.0" x="9025.0" y="217.5"/> </glyph> <glyph class="macromolecule" id="s7796_sa5257" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TFRC synonyms:TFR1,transferrin receptor Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 Fe 3+ is imported into cells through the membrane protein transferrin receptor 1 (TFR1) and then locates in the endosome. PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="TFRC"/> <bbox w="80.0" h="50.0" x="9540.0" y="195.0"/> <glyph class="unit of information" id="_5f3e49bf-bc03-4cdb-b938-9792471a0b63"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9557.5" y="190.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7800_sa5261" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: STEAP3 metalloreductase HUGO:STEAP3 hgnc_id:HGNC:24592 HGNC:24592 ENTREZ:55240 UNIPROT:Q658P3 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="STEAP3"/> <bbox w="80.0" h="40.0" x="9550.0" y="285.0"/> </glyph> <glyph class="macromolecule" id="s7802_sa5263" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:SLC11A2 synonyms:DMT1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC11A2"/> <clone/> <bbox w="80.0" h="50.0" x="9700.0" y="310.0"/> <glyph class="unit of information" id="_e1e7c8e1-b8ae-432a-92c0-7a71f42f2684"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9717.5" y="305.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7802_sa5299" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:SLC11A2 synonyms:DMT1 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC11A2"/> <clone/> <bbox w="80.0" h="50.0" x="9470.0" y="370.0"/> <glyph class="unit of information" id="_3206fe32-9033-4dce-9eb9-2d33383ebb6d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9487.5" y="365.0"/> </glyph> </glyph> <glyph class="complex" id="s7803_csa530" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FTH1:FTL Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Ferritin*"/> <bbox w="100.0" h="120.0" x="9670.0" y="470.0"/> <glyph class="macromolecule" id="s7804_sa5265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, light polypeptide HUGO:FTL HGNC:3999 ENTREZ:2512 UNIPROT:P02792 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="FTL"/> <bbox w="80.0" h="40.0" x="9680.0" y="480.0"/> </glyph> <glyph class="macromolecule" id="s7805_sa5266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:FTH1 HGNC:3976 ENTREZ:2495 UNIPROT:P02794 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:17603935 Ferritin is an iron storage protein and its concentration is inversely related to the level of Labile Iron Pool. References_end </body> </html> </notes> <label text="FTH1"/> <bbox w="80.0" h="40.0" x="9680.0" y="520.0"/> </glyph> </glyph> <glyph class="complex" id="s7810_csa531" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FTH1:FTL:Fe2+ Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Ferritin*:Fe2+"/> <bbox w="100.0" h="150.0" x="9870.0" y="455.0"/> <glyph class="simple chemical" id="s7807_sa5267"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end </body> </html> </notes> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="9897.5" y="462.5"/> </glyph> <glyph class="macromolecule" id="s7808_sa5268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, light polypeptide HUGO:FTL HGNC:3999 ENTREZ:2512 UNIPROT:P02792 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="FTL"/> <bbox w="80.0" h="40.0" x="9880.0" y="495.0"/> </glyph> <glyph class="macromolecule" id="s7809_sa5269"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:FTH1 HGNC:3976 ENTREZ:2495 UNIPROT:P02794 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:NECROPTOSIS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:17603935 Ferritin is an iron storage protein and its concentration is inversely related to the level of Labile Iron Pool. References_end </body> </html> </notes> <label text="FTH1"/> <bbox w="80.0" h="40.0" x="9880.0" y="535.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7811_sa5270" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:SLC40A1 synonyms:SLC11A3 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC40A1"/> <bbox w="80.0" h="50.0" x="9840.0" y="175.0"/> <glyph class="unit of information" id="_922e9ef9-4347-4f6c-a643-6e937024bd4d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9857.5" y="170.0"/> </glyph> </glyph> <glyph class="complex" id="s7819_csa532" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Deferoxamine:Fe2+ Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Deferoxamine:Fe2+"/> <bbox w="100.0" h="100.0" x="9930.0" y="330.0"/> <glyph class="simple chemical" id="s7820_sa5274"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end </body> </html> </notes> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="9957.5" y="377.5"/> </glyph> <glyph class="simple chemical" id="s7821_sa5275"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: PUBCHEM:2973 Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: CID 2973 PMID:23788428 iron chelator PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Deferoxamine"/> <bbox w="80.0" h="30.0" x="9940.0" y="345.0"/> <glyph class="unit of information" id="_2d13afb3-5165-44f3-8ae3-8a0130fd9764"> <label text="drug"/> <bbox w="25.0" h="10.0" x="9967.5" y="340.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s7822_sa5276" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 7 member 11 HUGO:SLC7A11 hgnc_id:HGNC:11059 HGNC:11059 ENTREZ:23657 UNIPROT:Q9UPY5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC7A11"/> <bbox w="80.0" h="50.0" x="7801.0" y="6865.0"/> <glyph class="unit of information" id="_7556b41e-97de-4de4-89aa-03c43685904e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7818.5" y="6860.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7823_sa5277" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 7 member 11 HUGO:SLC7A11 hgnc_id:HGNC:11059 HGNC:11059 ENTREZ:23657 UNIPROT:Q9UPY5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SLC7A11"/> <bbox w="90.0" h="25.0" x="7796.0" y="7067.5"/> <glyph class="unit of information" id="_e38f5b36-33f5-4e2e-810f-fb319af13b13"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7831.0" y="7062.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7824_sa5278" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 7 member 11 HUGO:SLC7A11 hgnc_id:HGNC:11059 HGNC:11059 ENTREZ:23657 UNIPROT:Q9UPY5 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 p53 is a positive regulator of ferroptosis in certain cancer cells by inhibition of SLC7A11 expression References_end </body> </html> </notes> <label text="SLC7A11"/> <bbox w="70.0" h="25.0" x="7806.0" y="7187.5"/> </glyph> <glyph class="macromolecule" id="s7829_sa5280" compartmentRef="c44_ca49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="9555.0" y="1210.0"/> <glyph class="state variable" id="_79955ab6-8e5a-47b6-adf3-ed3d9fd0850e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9573.432" y="1205.0"/> </glyph> <glyph class="state variable" id="_8c9f547d-9b0d-4f27-90ad-d53c8e61e166"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9604.068" y="1205.0"/> </glyph> <glyph class="state variable" id="_21a4a553-9878-41f0-97a4-f85dd84d2db0"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9585.0" y="1245.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7833_sa5281" compartmentRef="c44_ca49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="9685.0" y="1210.0"/> <glyph class="state variable" id="_1aa80116-545e-429a-81dc-1e305afd6999"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9700.932" y="1205.0"/> </glyph> <glyph class="state variable" id="_4c112b4f-206f-4e74-a208-f214b363cba5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9734.068" y="1205.0"/> </glyph> <glyph class="state variable" id="_1d3a0d7b-95b7-4ed9-bf2f-7eedada3b9d6"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9715.0" y="1245.0"/> </glyph> </glyph> <glyph class="source and sink" id="s7835_sa5288" compartmentRef="c44_ca49"> <label text="s7835"/> <bbox w="30.0" h="30.0" x="9940.0" y="1245.0"/> </glyph> <glyph class="complex" id="s7836_csa533" compartmentRef="c44_ca49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KEAP1:SQSTM1 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="SQSTM1:KEAP1"/> <bbox w="100.0" h="120.0" x="9795.0" y="1200.0"/> <glyph class="macromolecule" id="s7834_sa5282"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <bbox w="80.0" h="40.0" x="9805.0" y="1260.0"/> </glyph> <glyph class="macromolecule" id="s7837_sa5283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="9805.0" y="1220.0"/> <glyph class="state variable" id="_1c85ede6-a64e-4e12-b393-5c4488ca2990"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9820.932" y="1215.0"/> </glyph> <glyph class="state variable" id="_366a84c6-b388-44b7-8c26-5de88b66f4ee"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9854.068" y="1215.0"/> </glyph> <glyph class="state variable" id="_e32daa9b-cb75-4668-8e56-a8c3c880d4e7"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9835.0" y="1255.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s7838_csa534" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KEAP1:NFE2L2 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="NFE2L2:KEAP1"/> <bbox w="100.0" h="130.0" x="9570.0" y="1500.0"/> <glyph class="macromolecule" id="s7839_sa5286"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: nuclear factor (erythroid-derived 2)-like 2 HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 NOTE: * means activated form References_end </body> </html> </notes> <label text="NFE2L2"/> <bbox w="80.0" h="40.0" x="9580.0" y="1560.0"/> <glyph class="state variable" id="_d144a89f-3b97-4d16-8eaa-8bc302762b78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9631.568" y="1555.0"/> </glyph> <glyph class="state variable" id="_f859468a-c041-41de-b567-d6f508d0b0bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9598.432" y="1555.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7840_sa5287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: kelch-like ECH-associated protein 1 HUGO:KEAP1 HGNC:23177 ENTREZ:9817 UNIPROT:Q14145 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="KEAP1"/> <bbox w="80.0" h="40.0" x="9580.0" y="1510.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7845_sa5289" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NAD(P)H quinone dehydrogenase 1 HUGO:NQO1 hgnc_id:HGNC:2874 HGNC:2874 ENTREZ:1728 UNIPROT:P15559 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:24011591 References_end </body> </html> </notes> <label text="NQO1"/> <bbox w="70.0" h="25.0" x="7895.0" y="7187.5"/> </glyph> <glyph class="nucleic acid feature" id="s7846_sa5290" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NAD(P)H quinone dehydrogenase 1 HUGO:NQO1 hgnc_id:HGNC:2874 HGNC:2874 ENTREZ:1728 UNIPROT:P15559 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:24011591 References_end </body> </html> </notes> <label text="NQO1"/> <bbox w="90.0" h="25.0" x="7885.0" y="7067.5"/> <glyph class="unit of information" id="_78e924e8-0658-4a50-a216-752c9c193505"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7920.0" y="7062.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7847_sa5291" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: NAD(P)H quinone dehydrogenase 1 HUGO:NQO1 hgnc_id:HGNC:2874 HGNC:2874 ENTREZ:1728 UNIPROT:P15559 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:24011591 References_end </body> </html> </notes> <label text="NQO1"/> <bbox w="80.0" h="40.0" x="7890.0" y="6870.0"/> </glyph> <glyph class="complex" id="s7848_csa441" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NRIF*:SQSTM1 Identifiers_end References_begin: 16252010 References_end </body> </html> </notes> <label text="NRIF*:SQSTM1"/> <bbox w="107.5" h="135.0" x="7746.25" y="7372.5"/> <glyph class="macromolecule" id="s5862_sa4251"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: sequestosome 1 HUGO:SQSTM1 HGNC:11280 ENTREZ:8878 UNIPROT:Q13501 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:FAS_RESPONSE MODULE:TRAIL_RESPONSE MODULE:ER_STRESS MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:26587781 Sequestosme 1, p62 PMID:20531300 PMID:16252010 PMID:15340068 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.PMID:19450509 polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC PMID:28574505 References_end </body> </html> </notes> <label text="SQSTM1"/> <bbox w="80.0" h="40.0" x="7763.75" y="7437.5"/> <glyph class="state variable" id="_e0e07098-fc2d-4db2-bc73-e3380eec5962"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7782.1816" y="7432.5"/> </glyph> <glyph class="state variable" id="_395c2a04-123e-40a2-b782-a74ae955f4b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.3184" y="7432.5"/> </glyph> <glyph class="state variable" id="_02f1635d-034b-4a44-a6d4-44d53a54d9dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7798.75" y="7472.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s5863_sa4252"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: integrin beta 3 binding protein (beta3-endonexin) HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: PMID:15721744 PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. References_end </body> </html> </notes> <label text="NRIF*"/> <bbox w="80.0" h="40.0" x="7763.75" y="7387.5"/> <glyph class="state variable" id="_cde62a32-5fa5-42f2-87ef-233350930885"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7810.3184" y="7382.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s7850_csa289" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BACH1:heme Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1:heme"/> <bbox w="100.0" h="110.0" x="11660.0" y="7585.0"/> <glyph class="macromolecule" id="s7851_sa2341"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="11668.029" y="7602.4683"/> </glyph> <glyph class="simple chemical" id="s7852_sa2342"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> CHEBI:30413 </body> </html> </notes> <label text="heme"/> <bbox w="70.0" h="25.0" x="11671.029" y="7641.4683"/> </glyph> </glyph> <glyph class="macromolecule" id="s7853_sa2343" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BTB and CNC homology 1, basic leucine zipper transcription factor 1 HUGO:BACH1 HGNC:935 ENTREZ:571 UNIPROT:O14867 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:RCD_GENES MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="BACH1"/> <bbox w="80.0" h="40.0" x="11770.0" y="7790.0"/> </glyph> <glyph class="simple chemical" id="s7854_sa5294" compartmentRef="c1_ca1"> <label text="OH-"/> <bbox w="70.0" h="25.0" x="9125.0" y="297.5"/> </glyph> <glyph class="phenotype" id="s7812_sa5272" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26653790 Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. PMID:17568748 PMID:28645028 PMID:27048813 PMID:28552631 PMID:26794443 Ferroptosis is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrialmembrane rupture. References_end </body> </html> </notes> <label text="Ferroptosis"/> <bbox w="120.0" h="25.0" x="9000.0" y="407.5"/> </glyph> <glyph class="simple chemical" id="s7855_sa5298" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: L-selenocysteine CHEBI:16633 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="L-selenocysteine"/> <bbox w="70.0" h="25.0" x="9665.0" y="777.5"/> </glyph> <glyph class="complex" id="s7856_csa535" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GPX4:L-selenocysteine Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-selenocysteine:GPX4"/> <bbox w="100.0" h="100.0" x="9490.0" y="760.0"/> <glyph class="macromolecule" id="s7857_sa5245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione peroxidase 4 HUGO:GPX4 hgnc_id:HGNC:4556 HGNC:4556 ENTREZ:2879 UNIPROT:P36969 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26653790 Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. References_end </body> </html> </notes> <label text="GPX4"/> <bbox w="80.0" h="40.0" x="9500.0" y="770.0"/> </glyph> <glyph class="simple chemical" id="s7858_sa5296"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: L-selenocysteine CHEBI:16633 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: References_end </body> </html> </notes> <label text="L-selenocysteine"/> <bbox w="70.0" h="25.0" x="9505.0" y="817.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7860_sa5304" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TRU-TCA1-1 synonyms:tRNA(Sec) Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="TRU-TCA1-1"/> <bbox w="90.0" h="25.0" x="9755.0" y="697.5"/> <glyph class="unit of information" id="_0e951a3d-9e52-4025-99f4-4d0361acac24"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9790.0" y="692.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s7861_sa5301" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: glutathione peroxidase 4 HUGO:GPX4 hgnc_id:HGNC:4556 HGNC:4556 ENTREZ:2879 UNIPROT:P36969 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="GPX4"/> <bbox w="90.0" h="25.0" x="9655.0" y="947.5"/> <glyph class="unit of information" id="_2d1667bb-3088-4c5a-9b99-2fddbfa97caf"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9690.0" y="942.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7862_sa5302" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TRIT1 tRNA isopentenyltransferase 1 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="TRIT1"/> <bbox w="80.0" h="40.0" x="9870.0" y="800.0"/> </glyph> <glyph class="simple chemical" id="s7863_sa5303" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: isopentenyl diphosphate CHEBI:16584 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="isopentenyl diphosphate"/> <bbox w="155.0" h="22.5" x="9795.0" y="737.5"/> </glyph> <glyph class="simple chemical" id="s7868_sa5307" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16811 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="Methionine"/> <bbox w="70.0" h="25.0" x="8715.0" y="897.5"/> </glyph> <glyph class="simple chemical" id="s7869_sa5308" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15414 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="S-Adénosylméthionine"/> <bbox w="135.0" h="22.5" x="8870.0" y="900.0"/> </glyph> <glyph class="simple chemical" id="s7870_sa5309" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16680 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="S-Adénosylhomocystéine"/> <bbox w="155.0" h="32.5" x="8862.5" y="993.75"/> </glyph> <glyph class="simple chemical" id="s7871_sa5310" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17588 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="Homocystéine"/> <bbox w="70.0" h="25.0" x="8715.0" y="997.5"/> </glyph> <glyph class="simple chemical" id="s7872_sa5311" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17482 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="Cystathionine"/> <bbox w="85.0" h="22.5" x="8707.5" y="1158.75"/> </glyph> <glyph class="simple chemical" id="s7873_sa5313" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:5951 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="Sérine"/> <bbox w="70.0" h="25.0" x="8645.0" y="1047.5"/> </glyph> <glyph class="simple chemical" id="s7874_sa5315" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:30831 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS MODULE:GLUCOSE_METABOLISM Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="alpha-Ketobutyric acid"/> <bbox w="135.0" h="22.5" x="8795.0" y="1217.5"/> </glyph> <glyph class="macromolecule" id="s7875_sa5318" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ferritin, light polypeptide HUGO:CARS Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26184909 References_end </body> </html> </notes> <label text="CARS"/> <bbox w="80.0" h="40.0" x="9030.0" y="1070.0"/> </glyph> <glyph class="simple chemical" id="s7876_sa5319" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29167 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26184909 References_end </body> </html> </notes> <label text="tRNACys"/> <bbox w="70.0" h="25.0" x="8955.0" y="1197.5"/> </glyph> <glyph class="simple chemical" id="s7877_sa5320" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29152 L-Cysteinyl-tRNA(Cys) Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26184909 References_end </body> </html> </notes> <label text="Cys-tRNA(Cys)"/> <bbox w="115.0" h="22.5" x="9152.5" y="1158.75"/> </glyph> <glyph class="simple chemical" id="s7878_sa5321" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18361 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26184909 References_end </body> </html> </notes> <label text="diphosphate"/> <bbox w="85.0" h="22.5" x="9102.5" y="1118.75"/> </glyph> <glyph class="simple chemical" id="s7880_sa5326" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29309 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="CH3"/> <bbox w="70.0" h="25.0" x="8992.5" y="968.75"/> </glyph> <glyph class="simple chemical" id="s7881_sa5327" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16335 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="Adenosine"/> <bbox w="70.0" h="25.0" x="8765.0" y="1047.5"/> </glyph> <glyph class="simple chemical" id="s7882_sa5329" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:20612 synonyms:5-methyltetrahydrofolate Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="Levomefolic acid"/> <bbox w="105.0" h="22.5" x="8600.0" y="977.5"/> </glyph> <glyph class="simple chemical" id="s7883_sa5330" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:20506 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="Tetrahydrofolic acid"/> <bbox w="125.0" h="22.5" x="8600.0" y="937.5"/> </glyph> <glyph class="simple chemical" id="s7884_sa5333" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:28938 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="NH4+"/> <bbox w="70.0" h="25.0" x="8882.5" y="1118.75"/> </glyph> <glyph class="simple chemical" id="s7886_sa5262" compartmentRef="c30_ca48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="9647.5" y="372.5"/> </glyph> <glyph class="simple chemical" id="s7905_sa5239" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16283 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-cystine"/> <bbox w="70.0" h="25.0" x="8755.0" y="342.5"/> </glyph> <glyph class="macromolecule" id="s3814_sa2835" compartmentRef="c11_ca11"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) HUGO:GZMA HGNC:4708 ENTREZ:3001 UNIPROT:P12544 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end </body> </html> </notes> <label text="GZMA"/> <bbox w="80.0" h="40.0" x="2448.0" y="3539.0"/> </glyph> <glyph class="macromolecule" id="s3815_sa2836" compartmentRef="c11_ca11"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) HUGO:GZMB HGNC:4709 ENTREZ:3002 UNIPROT:P10144 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="GZMB"/> <bbox w="80.0" h="40.0" x="2443.0" y="3463.0"/> </glyph> <glyph class="nucleic acid feature" id="s7915_sa5334" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ferritin, heavy polypeptide 1 HUGO:IREB2 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS MODULE:NECROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="IREB2"/> <bbox w="70.0" h="25.0" x="7925.0" y="7597.5"/> </glyph> <glyph class="nucleic acid feature" id="s7916_sa5335" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: iron responsive element binding protein 2 HUGO:IREB2 hgnc_id:HGNC:6115 HGNC:6115 ENTREZ:3658 UNIPROT:P48200 Identifiers_end </body> </html> </notes> <label text="IREB2"/> <bbox w="90.0" h="25.0" x="7915.0" y="7497.5"/> <glyph class="unit of information" id="_1b499d05-c4f8-481a-af83-c96f32d85a16"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7950.0" y="7492.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7917_sa5336" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: iron responsive element binding protein 2 HUGO:IREB2 hgnc_id:HGNC:6115 HGNC:6115 ENTREZ:3658 UNIPROT:P48200 Identifiers_end </body> </html> </notes> <label text="IREB2"/> <bbox w="80.0" h="40.0" x="8070.0" y="7490.0"/> </glyph> <glyph class="nucleic acid feature" id="s7918_sa5337" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transferrin receptor HUGO:TFRC hgnc_id:HGNC:11763 HGNC:11763 ENTREZ:7037 UNIPROT:P02786 Identifiers_end </body> </html> </notes> <label text="TFRC"/> <bbox w="70.0" h="25.0" x="8225.0" y="7537.5"/> </glyph> <glyph class="nucleic acid feature" id="s7919_sa5338" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transferrin receptor HUGO:TFRC hgnc_id:HGNC:11763 HGNC:11763 ENTREZ:7037 UNIPROT:P02786 Identifiers_end </body> </html> </notes> <label text="TFRC"/> <bbox w="90.0" h="25.0" x="8215.0" y="7457.5"/> <glyph class="unit of information" id="_64f29f5d-63a1-4c02-9054-683e700efbfe"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8250.0" y="7452.5"/> </glyph> </glyph> <glyph class="source and sink" id="s7920_sa5339" compartmentRef="c13_ca13"> <label text="s7920"/> <bbox w="30.0" h="30.0" x="8095.0" y="7405.0"/> </glyph> <glyph class="simple chemical" id="s7921_sa5340" compartmentRef="c13_ca13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe2+"/> <bbox w="25.0" h="25.0" x="8157.5" y="7447.5"/> </glyph> <glyph class="macromolecule" id="s7926_sa5341" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:ACSF2 Acyl-CoA synthetase family member 2 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis PMID:28645028 References_end </body> </html> </notes> <label text="ACSF2"/> <bbox w="80.0" h="40.0" x="1240.0" y="2910.0"/> </glyph> <glyph class="macromolecule" id="s7927_sa5342" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:ACSF2 Acyl-CoA synthetase family member 2 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis. Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis PMID:28645028 References_end </body> </html> </notes> <label text="ACSF2"/> <bbox w="80.0" h="40.0" x="1390.0" y="5810.0"/> </glyph> <glyph class="simple chemical" id="s7929_sa5345" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18110 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS MODULE:GLUCOSE_METABOLISM Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="3-phosphonooxypyruvate"/> <bbox w="175.0" h="22.5" x="8365.0" y="1157.5"/> </glyph> <glyph class="simple chemical" id="s7930_sa5347" compartmentRef="c1_ca1"> <label text="3-P-serine"/> <bbox w="70.0" h="25.0" x="8417.5" y="1046.25"/> </glyph> <glyph class="macromolecule" id="s7931_sa5353" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphoglycerate dehydrogenase HUGO:PHGDH hgnc_id:HGNC:8923 HGNC:8923 ENTREZ:26227 UNIPROT:O43175 Identifiers_end </body> </html> </notes> <label text="PHGDH"/> <bbox w="80.0" h="40.0" x="8252.5" y="1208.75"/> </glyph> <glyph class="macromolecule" id="s7932_sa5354" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphoserine aminotransferase 1 HUGO:PSAT1 hgnc_id:HGNC:19129 HGNC:19129 ENTREZ:29968 UNIPROT:Q9Y617 Identifiers_end </body> </html> </notes> <label text="PSAT1"/> <bbox w="80.0" h="40.0" x="8232.5" y="1088.75"/> </glyph> <glyph class="macromolecule" id="s7933_sa5355" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphoserine phosphatase HUGO:PSPH hgnc_id:HGNC:9577 HGNC:9577 ENTREZ:5723 UNIPROT:P78330 Identifiers_end </body> </html> </notes> <label text="PSPH"/> <bbox w="80.0" h="40.0" x="8412.5" y="928.75"/> </glyph> <glyph class="simple chemical" id="s7960_sa2608" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17561 KEGGCOMPOUND:C00097 CAS:52-90-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="L-cysteine"/> <clone/> <bbox w="70.0" h="25.0" x="8701.0" y="679.5"/> </glyph> <glyph class="simple chemical" id="s7960_sa5314" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17561 KEGGCOMPOUND:C00097 CAS:52-90-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="L-cysteine"/> <clone/> <bbox w="70.0" h="25.0" x="8922.5" y="1158.75"/> </glyph> <glyph class="simple chemical" id="s7960_sa5316" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17561 KEGGCOMPOUND:C00097 CAS:52-90-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="L-cysteine"/> <clone/> <bbox w="70.0" h="25.0" x="8795.0" y="432.5"/> </glyph> <glyph class="simple chemical" id="s7960_sa5317" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17561 KEGGCOMPOUND:C00097 CAS:52-90-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:21435402 References_end </body> </html> </notes> <label text="L-cysteine"/> <clone/> <bbox w="70.0" h="25.0" x="8715.0" y="432.5"/> </glyph> <glyph class="simple chemical" id="s7961_sa5237" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamate"/> <clone/> <bbox w="70.0" h="25.0" x="8845.0" y="102.5"/> </glyph> <glyph class="simple chemical" id="s7961_sa5242" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:29988 KEGGCOMPOUND:C00025 CAS:56-86-0 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="L-glutamate"/> <clone/> <bbox w="70.0" h="25.0" x="8965.0" y="72.5"/> </glyph> <glyph class="simple chemical" id="s7962_sa5238" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16283 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 PMID:26653790 References_end </body> </html> </notes> <label text="L-cystine"/> <bbox w="70.0" h="25.0" x="8755.0" y="102.5"/> </glyph> <glyph class="simple chemical" id="s7963_sa5258" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe3+"/> <clone/> <bbox w="25.0" h="25.0" x="9647.5" y="147.5"/> </glyph> <glyph class="simple chemical" id="s7963_sa5271" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe3+"/> <clone/> <bbox w="25.0" h="25.0" x="9797.5" y="137.5"/> </glyph> <glyph class="simple chemical" id="s7964_sa5259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe3+"/> <clone/> <bbox w="25.0" h="25.0" x="9647.5" y="257.5"/> </glyph> <glyph class="simple chemical" id="s7964_sa5293" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="Fe3+"/> <clone/> <bbox w="25.0" h="25.0" x="9117.5" y="247.5"/> </glyph> <glyph class="simple chemical" id="s7965_sa5325" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pyrophosphates inorganiques CHEBI:62889 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="PPi"/> <clone/> <bbox w="70.0" h="25.0" x="8925.0" y="857.5"/> </glyph> <glyph class="simple chemical" id="s7965_sa5360" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pyrophosphates inorganiques CHEBI:62889 Identifiers_end Maps_Modules_begin: MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="PPi"/> <clone/> <bbox w="70.0" h="25.0" x="8547.5" y="1006.25"/> </glyph> <glyph class="macromolecule" id="s7966_sa4450" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <clone/> <bbox w="110.0" h="40.0" x="11629.5" y="2449.5"/> <glyph class="state variable" id="_b89171d8-3adb-4746-b5c4-b5fd3e43c0ee"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11619.5" y="2456.2158"/> </glyph> </glyph> <glyph class="macromolecule" id="s7966_sa4460" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: symbol withdrawn, see HUGO:A2MRAP~withdrawn HGNC:10 Identifiers_end References_begin: PMID:20531300 PMID:16498403 PMID:11583996 PMID:23377657 apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation PMID:27984721 References_end </body> </html> </notes> <label text="Caspase8,10*"/> <clone/> <bbox w="110.0" h="40.0" x="11364.929" y="2185.2144"/> <glyph class="state variable" id="_10be933a-7f2a-4064-acea-e65b092b836b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="11354.929" y="2191.9302"/> </glyph> </glyph> <glyph class="complex" id="s7967_csa93" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1"/> <clone/> <bbox w="101.5" h="170.5" x="9808.5" y="2739.5"/> <glyph class="macromolecule" id="s7968_sa1114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <clone/> <bbox w="80.0" h="40.0" x="9820.0" y="2790.0"/> </glyph> <glyph class="macromolecule" id="s7969_sa1115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <clone/> <bbox w="80.0" h="40.0" x="9820.0" y="2840.0"/> <glyph class="state variable" id="_23aa3cf2-a8d1-4423-be2b-a90d6fb74ef0"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9861.949" y="2835.0"/> </glyph> <glyph class="state variable" id="_05dfaf36-86ca-447a-a0b5-e3c78f18d900"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="9828.595" y="2835.0"/> </glyph> <glyph class="state variable" id="_44697c12-5253-46ec-9018-bf7b6995707b"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9835.932" y="2875.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7970_sa1116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <clone/> <bbox w="80.0" h="40.0" x="9815.5" y="2745.5"/> </glyph> </glyph> <glyph class="complex" id="s7967_csa300" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end </body> </html> </notes> <label text="mTORC1"/> <clone/> <bbox w="100.0" h="170.0" x="9620.0" y="2740.0"/> <glyph class="macromolecule" id="s7968_sa2573"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end References_begin: synonym:FRAP1 PMID:28216025 References_end </body> </html> </notes> <label text="MTOR"/> <clone/> <bbox w="80.0" h="40.0" x="9630.0" y="2790.0"/> </glyph> <glyph class="macromolecule" id="s7969_sa2574"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: regulatory associated protein of MTOR, complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="RPTOR"/> <clone/> <bbox w="80.0" h="40.0" x="9630.0" y="2840.0"/> <glyph class="state variable" id="_8c870a44-19dc-4be9-bad9-c602872e2922"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="9671.949" y="2835.0"/> </glyph> <glyph class="state variable" id="_3ccf17cb-c86a-4b9b-8227-cbddc2275baa"> <state value="" variable="S722"/> <bbox w="30.0" h="10.0" x="9638.595" y="2835.0"/> </glyph> <glyph class="state variable" id="_3fda18a8-42a6-4fa0-9f44-0fe3c07d91f1"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9645.932" y="2875.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7970_sa2575"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: MTOR associated protein, LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:FATTY_ACID_BIOSYNTHESIS MODULE:MOMP_REGULATION MODULE:RCD_GENES Maps_Modules_end </body> </html> </notes> <label text="MLST8"/> <clone/> <bbox w="80.0" h="40.0" x="9630.0" y="2750.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7971_sa5361" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: C-C motif chemokine ligand 19 HUGO:CCL19 hgnc_id:HGNC:10617 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="CK*"/> <bbox w="80.0" h="40.0" x="5970.0" y="3710.0"/> </glyph> <glyph class="simple chemical" id="s6802_sa3367" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="5809.0" y="5919.25"/> </glyph> <glyph class="simple chemical" id="s6802_sa5383" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5 Identifiers_end </body> </html> </notes> <label text="ATP"/> <clone/> <bbox w="70.0" h="25.0" x="5585.0" y="3867.5"/> </glyph> <glyph class="simple chemical" id="s6801_sa3366" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16761 KEGGCOMPOUND:C00008 CAS:58-64-0 Identifiers_end </body> </html> </notes> <label text="ADP"/> <clone/> <bbox w="70.0" h="25.0" x="5805.0" y="5797.5"/> </glyph> <glyph class="simple chemical" id="s6801_sa5382" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:16761 KEGGCOMPOUND:C00008 CAS:58-64-0 Identifiers_end </body> </html> </notes> <label text="ADP"/> <clone/> <bbox w="70.0" h="25.0" x="5495.0" y="3867.5"/> </glyph> <glyph class="macromolecule" id="s7972_sa3049" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: endonuclease G HUGO:ENDOG HGNC:3346 ENTREZ:2021 UNIPROT:Q14249 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DNA_DAMAGE_RESPONSE MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:PARTHANATOS Maps_Modules_end </body> </html> </notes> <label text="ENDOG"/> <bbox w="80.0" h="40.0" x="5220.0" y="6235.0"/> </glyph> <glyph class="macromolecule" id="s7973_sa1812" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenylate kinase 2 HUGO:AK2 HGNC:362 ENTREZ:204 UNIPROT:P54819 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MOMP_REGULATION Maps_Modules_end </body> </html> </notes> <label text="AK2"/> <bbox w="80.0" h="40.0" x="5320.0" y="6235.0"/> </glyph> <glyph class="simple chemical" id="s1497_sa2269" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="70.0" h="25.0" x="11415.0" y="1677.5"/> </glyph> <glyph class="simple chemical" id="s1497_sa2658" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="70.0" h="25.0" x="7060.25" y="4373.75"/> </glyph> <glyph class="simple chemical" id="s1497_sa2661" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="70.0" h="25.0" x="6485.4375" y="5248.0"/> </glyph> <glyph class="simple chemical" id="s1497_sa2808" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="70.0" h="25.0" x="1820.0" y="2530.0"/> </glyph> <glyph class="simple chemical" id="s1497_sa3165" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="70.0" h="25.0" x="4750.0" y="1510.0"/> </glyph> <glyph class="simple chemical" id="s1497_sa4280" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:PENTOSE_PHOSPHATE_PATHWAY Maps_Modules_end </body> </html> </notes> <label text="TXN"/> <clone/> <bbox w="70.0" h="25.0" x="1880.0" y="2840.0"/> </glyph> <glyph class="macromolecule" id="s7974_sa5362" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: creatine kinase, mitochondrial 1A HUGO:CKMT1A hgnc_id:HGNC:31736 HGNC:31736 ENTREZ:548596 UNIPROT:P12532 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="CKMT1A"/> <bbox w="80.0" h="40.0" x="5830.0" y="3680.0"/> </glyph> <glyph class="macromolecule" id="s7975_sa5363" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: creatine kinase, mitochondrial 1B HUGO:CKMT1B hgnc_id:HGNC:1995 HGNC:1995 ENTREZ:1159 UNIPROT:P12532 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="CKMT1B"/> <bbox w="80.0" h="40.0" x="5730.0" y="3710.0"/> </glyph> <glyph class="macromolecule" id="s7976_sa5364" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: creatine kinase, mitochondrial 2 HUGO:CKMT2 hgnc_id:HGNC:1996 HGNC:1996 ENTREZ:1160 UNIPROT:P17540 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="CKMT2"/> <bbox w="80.0" h="40.0" x="5830.0" y="3740.0"/> </glyph> <glyph class="macromolecule" id="s7978_sa1146" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:17568748 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <bbox w="80.0" h="40.0" x="5600.0" y="5540.0"/> </glyph> <glyph class="macromolecule" id="s7979_sa3756" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:17568748 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <bbox w="80.0" h="40.0" x="6060.0" y="3790.0"/> </glyph> <glyph class="macromolecule" id="s3678_sa2678" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23430059 References_end </body> </html> </notes> <label text="BID"/> <bbox w="80.0" h="40.0" x="6858.75" y="2592.5"/> <glyph class="state variable" id="_f64bf6ed-38ae-4a5b-bb48-41f54babc8e3"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="6909.936" y="2587.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s7995_sa5369" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hexokinase 1 HUGO:HK1 hgnc_id:HGNC:4922 HGNC:4922 ENTREZ:3098 UNIPROT:P19367 hexokinase 2 HUGO:HK2 hgnc_id:HGNC:4923 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK*"/> <bbox w="80.0" h="40.0" x="6160.0" y="3930.0"/> </glyph> <glyph class="macromolecule" id="s8002_sa5376" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 HUGO:SLC25A4 HGNC:10990 ENTREZ:291 UNIPROT:P12235 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 HUGO:SLC25A5 HGNC:10991 ENTREZ:292 UNIPROT:P05141 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 HUGO:SLC25A6 HGNC:10992 ENTREZ:293 UNIPROT:P12236 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="ANT*"/> <bbox w="80.0" h="40.0" x="5700.0" y="3800.0"/> </glyph> <glyph class="macromolecule" id="s8003_sa5372" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TPSO synonyms:peripheral benzodiazepine receptor,PBR Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="TSPO"/> <bbox w="80.0" h="50.0" x="6060.0" y="3855.0"/> <glyph class="unit of information" id="_5c00ac01-55eb-4730-b720-e0da43dd2915"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6077.5" y="3850.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8027_sa1916" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: huntingtin HUGO:HTT HGNC:4851 ENTREZ:3064 UNIPROT:P42858 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="HTT"/> <bbox w="80.0" h="40.0" x="7631.334" y="4042.2764"/> </glyph> <glyph class="macromolecule" id="s8059_sa1757" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:STARVATION_AUTOPHAGY MODULE:CASPASES MODULE:GLUCOSE_METABOLISM MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS Maps_Modules_end References_begin: there are at least 2 isoforms of BAD. Here, protein BAD refers to any of the different isoforms. Numbering of amino-acids, used for phosphorylation sites, are adjusted to the 'canonical' isoform as defined in Uniprot. This lead to choosing different isoforms for different organisms. References_end </body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="5460.0" y="4100.0"/> <glyph class="state variable" id="_359c3a70-15b3-44fd-af3a-b6ff6fe31fb0"> <state value="active" variable=""/> <bbox w="40.0" h="10.0" x="5480.0" y="4095.0"/> </glyph> <glyph class="state variable" id="_8d39d361-0eac-4d5d-be08-950c9c1efebb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5478.595" y="4095.0"/> </glyph> <glyph class="state variable" id="_91de12d6-d23d-4e5a-ad2b-0a52b884cfba"> <state value="?" variable="S91"/> <bbox w="30.0" h="10.0" x="5501.949" y="4095.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8075_sa5388" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 4 HUGO:CASP4 hgnc_id:HGNC:1505 HGNC:1505 ENTREZ:837 UNIPROT:P49662 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="Caspase5*"/> <bbox w="80.0" h="40.0" x="10180.0" y="1170.0"/> </glyph> <glyph class="macromolecule" id="s8076_sa5389" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 4 HUGO:CASP4 hgnc_id:HGNC:1505 HGNC:1505 ENTREZ:837 UNIPROT:P49662 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="cleaved~Caspase5*"/> <bbox w="80.0" h="40.0" x="10310.0" y="1170.0"/> <glyph class="unit of information" id="_2d2284d5-bae2-4e93-a4d3-6012ad862fa1"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10325.0" y="1165.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8077_sa5390" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Caspase1*"/> <bbox w="80.0" h="40.0" x="10835.0" y="1006.25"/> </glyph> <glyph class="macromolecule" id="s8078_sa5391" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SR-related CTD associated factor 11 HUGO:SCAF11 hgnc_id:HGNC:10784 HGNC:10784 ENTREZ:9169 UNIPROT:Q99590 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Caspase11*"/> <bbox w="80.0" h="40.0" x="10760.0" y="1110.0"/> </glyph> <glyph class="macromolecule" id="s8079_sa5392" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="cleaved~Caspase1*"/> <bbox w="80.0" h="40.0" x="10685.0" y="1006.25"/> <glyph class="unit of information" id="_a4428136-bebe-45da-8cc5-af3a50532ad2"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10700.0" y="1001.25"/> </glyph> </glyph> <glyph class="macromolecule" id="s8080_sa5393" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: SR-related CTD associated factor 11 HUGO:SCAF11 hgnc_id:HGNC:10784 HGNC:10784 ENTREZ:9169 UNIPROT:Q99590 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="cleaved~Caspase11*"/> <bbox w="80.0" h="40.0" x="10600.0" y="1110.0"/> <glyph class="unit of information" id="_fcb2d5fd-d79d-4e76-a7bb-e65c12f5772e"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10615.0" y="1105.0"/> </glyph> </glyph> <glyph class="phenotype" id="s8088_sa5394" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 secreted by Gram negtive bacteria as Escherichia coli, Citrobacter rodentium, Vibrio cholerae PMID:27984721 References_end </body> </html> </notes> <label text="bacterial lipopolysaccharide (LPS)"/> <bbox w="220.0" h="25.0" x="10610.0" y="127.5"/> </glyph> <glyph class="macromolecule" id="s8090_sa5396" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:27439607 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:NLRP3 synonyms:NOD-like Receptor protein 3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27439607 References_end </body> </html> </notes> <label text="NLRP3"/> <clone/> <bbox w="80.0" h="50.0" x="10780.0" y="475.0"/> <glyph class="unit of information" id="_0d39efab-9137-4e40-aa4d-2ca64f094f38"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10797.5" y="470.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8090_sa5460" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:27439607 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:NLRP3 synonyms:NOD-like Receptor protein 3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27439607 References_end </body> </html> </notes> <label text="NLRP3"/> <clone/> <bbox w="80.0" h="50.0" x="10890.0" y="295.0"/> <glyph class="unit of information" id="_c1c740e2-5878-4d51-94fb-0b4b369c4a35"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10907.5" y="290.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8091_sa5462" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <clone/> <bbox w="80.0" h="50.0" x="10670.0" y="255.0"/> <glyph class="state variable" id="_be29b4ee-21fd-4ea3-b424-b36ce467d048"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10745.0" y="250.0"/> </glyph> <glyph class="unit of information" id="_7032bc7f-b87c-4a74-a8b2-32b230e71f8e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10687.5" y="250.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8091_sa5469" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <clone/> <bbox w="80.0" h="50.0" x="10420.0" y="375.0"/> <glyph class="state variable" id="_a2abc061-2331-4db3-8361-eb1605a312b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10495.0" y="370.0"/> </glyph> <glyph class="unit of information" id="_0fabc584-3e2f-4583-905a-1c6b88e63c06"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10437.5" y="370.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8092_sa5398" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:AIM2 synonyms:absent in melanoma 2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="AIM2"/> <clone/> <bbox w="80.0" h="50.0" x="11050.0" y="495.0"/> <glyph class="unit of information" id="_feebbfe9-615d-45d2-b399-f499530cdbd0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11067.5" y="490.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8092_sa5458" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:AIM2 synonyms:absent in melanoma 2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="AIM2"/> <clone/> <bbox w="80.0" h="50.0" x="11180.0" y="315.0"/> <glyph class="unit of information" id="_f3adb38e-c1bc-4add-991b-a7b14687a507"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11197.5" y="310.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8093_sa5399" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:MEFV synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="Pyrin*"/> <clone/> <bbox w="80.0" h="50.0" x="11350.0" y="475.0"/> <glyph class="unit of information" id="_c231a0dd-8cf0-4da2-8467-cbf37cd2a56d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11367.5" y="470.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8093_sa5435" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:MEFV synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="Pyrin*"/> <clone/> <bbox w="80.0" h="50.0" x="11460.0" y="305.0"/> <glyph class="unit of information" id="_589fa3c1-e951-4cbe-a28a-888126dd9551"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11477.5" y="300.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8101_sa5400" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:IL1B synonyms:interleukin 1 beta Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="IL1B"/> <bbox w="80.0" h="40.0" x="10940.0" y="1210.0"/> </glyph> <glyph class="macromolecule" id="s8102_sa5401" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:IL18 synonyms:interleukin 18 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="IL18"/> <bbox w="80.0" h="40.0" x="10940.0" y="1260.0"/> </glyph> <glyph class="complex" id="s8103_csa537" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NLRP1 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NLRP1:NLRP1"/> <bbox w="112.5" h="102.5" x="10122.5" y="643.75"/> <glyph class="macromolecule" id="s8104_sa5407"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, pyrin domain containing 1 HUGO:NLRP1 HGNC:14374 ENTREZ:22861 UNIPROT:Q9C000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19465923 Ptc–DRAL interaction represents an anchor for a specific TUCAN/NALP1-caspase-9-containing complex References_end </body> </html> </notes> <label text="NLRP1"/> <bbox w="80.0" h="50.0" x="10132.5" y="663.75"/> <glyph class="unit of information" id="_9ae56441-f02d-4171-8607-c676fc7e816b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10150.0" y="658.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s8104_sa5412"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, pyrin domain containing 1 HUGO:NLRP1 HGNC:14374 ENTREZ:22861 UNIPROT:Q9C000 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:DEPENDANCE_RECEPTORS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19465923 Ptc–DRAL interaction represents an anchor for a specific TUCAN/NALP1-caspase-9-containing complex References_end </body> </html> </notes> <label text="NLRP1"/> <bbox w="80.0" h="50.0" x="10142.5" y="673.75"/> <glyph class="unit of information" id="_a3296780-18fc-4a01-b0c7-7513f3a244a7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10160.0" y="668.75"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s8119_sa5424" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 GSDMD cleavage is sufficent to induce Pyroptosis PMID:27066895 References_end </body> </html> </notes> <label text="GSDMD"/> <bbox w="80.0" h="40.0" x="10515.0" y="896.25"/> </glyph> <glyph class="macromolecule" id="s8120_sa5425" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="cleaved~GSDMD"/> <bbox w="80.0" h="40.0" x="10515.0" y="986.25"/> <glyph class="unit of information" id="_77a53e34-c99a-432c-ac31-625d8940f507"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10530.0" y="981.25"/> </glyph> </glyph> <glyph class="phenotype" id="s8121_sa5426" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Pyroptosis Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 the amino-terminal gasdermin D domain may oligomerize to form a membrane pore akin to how MLKL may act during necroptosis [80, 81]. Alternatively, the pyroptotic gasdermin D domain may induce cell lysis indirectly by damaging intracellular organelles that result in disruption of mitochondrial respiration and ATP synthesis PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Pyroptosis"/> <bbox w="80.0" h="30.0" x="10325.0" y="991.25"/> </glyph> <glyph class="macromolecule" id="s8122_sa5427" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dual specificity phosphatase and pro isomerase domain containing 1 HUGO:DUPD1 hgnc_id:HGNC:23481 HGNC:23481 ENTREZ:338599 UNIPROT:Q68J44 Identifiers_end </body> </html> </notes> <label text="pro-IL1B*"/> <bbox w="80.0" h="40.0" x="10800.0" y="1210.0"/> </glyph> <glyph class="macromolecule" id="s8123_sa5428" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: dual specificity phosphatase and pro isomerase domain containing 1 HUGO:DUPD1 hgnc_id:HGNC:23481 HGNC:23481 ENTREZ:338599 UNIPROT:Q68J44 Identifiers_end </body> </html> </notes> <label text="pro-IL18*"/> <bbox w="80.0" h="40.0" x="10800.0" y="1260.0"/> </glyph> <glyph class="complex" id="s8144_csa544" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PYCARD:Pyrin* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Pyrin*:PYCARD"/> <bbox w="100.0" h="140.0" x="11450.0" y="430.0"/> <glyph class="macromolecule" id="s8176_sa5418"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="11460.0" y="500.0"/> </glyph> <glyph class="macromolecule" id="s8177_sa5433"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:MEFV synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="Pyrin*"/> <bbox w="80.0" h="50.0" x="11460.0" y="445.0"/> <glyph class="unit of information" id="_77852fc3-2e51-4f96-9d1b-53e397fc85e6"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11477.5" y="440.0"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="s8147_sa5437" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Caspase1*"/> <bbox w="80.0" h="40.0" x="11710.0" y="910.0"/> </glyph> <glyph class="complex" id="s8148_csa543" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase1*:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="ASC:Caspase1*"/> <bbox w="100.0" h="120.0" x="11530.0" y="840.0"/> <glyph class="macromolecule" id="s8149_sa5429"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="11540.0" y="850.0"/> </glyph> <glyph class="macromolecule" id="s8152_sa5438"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Caspase1*"/> <bbox w="80.0" h="40.0" x="11540.0" y="890.0"/> </glyph> </glyph> <glyph class="complex" id="s8150_csa542" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase1*:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="ASC:Caspase1*:ASC:Caspase1*"/> <bbox w="122.5" h="132.5" x="10742.5" y="826.25"/> <glyph class="macromolecule" id="s8151_sa5417"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Caspase1*"/> <bbox w="80.0" h="40.0" x="10757.5" y="878.75"/> </glyph> <glyph class="macromolecule" id="s8151_sa5416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 References_end </body> </html> </notes> <label text="Caspase1*"/> <bbox w="80.0" h="40.0" x="10767.5" y="888.75"/> </glyph> <glyph class="macromolecule" id="s8154_sa5439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="10757.5" y="838.75"/> </glyph> <glyph class="macromolecule" id="s8154_sa5440"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="10767.5" y="848.75"/> </glyph> </glyph> <glyph class="complex" id="s8155_csa541" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PYCARD:Pyrin* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Pyrin*:Pyrin*:PYCARD"/> <bbox w="107.5" h="142.5" x="11367.5" y="643.75"/> <glyph class="macromolecule" id="s8156_sa5410"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:MEFV synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="Pyrin*"/> <bbox w="80.0" h="50.0" x="11377.5" y="658.75"/> <glyph class="unit of information" id="_500f48a1-05bd-49fc-ba40-37058d425e81"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11395.0" y="653.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s8156_sa5415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:MEFV synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="Pyrin*"/> <bbox w="80.0" h="50.0" x="11387.5" y="668.75"/> <glyph class="unit of information" id="_3b6151a4-cd77-4784-a06c-6d3b1e106332"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11405.0" y="663.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s8118_sa5421"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="11387.5" y="723.75"/> </glyph> </glyph> <glyph class="complex" id="s8157_csa540" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AIM2:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="AIM2:AIM2:PYCARD"/> <bbox w="120.0" h="145.0" x="11030.0" y="647.5"/> <glyph class="macromolecule" id="s8158_sa5409"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:AIM2 synonyms:absent in melanoma 2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="AIM2"/> <bbox w="80.0" h="50.0" x="11045.0" y="662.5"/> <glyph class="unit of information" id="_3b9c68db-ce63-444d-a5d1-3f2101a9c6ae"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11062.5" y="657.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s8158_sa5414"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:AIM2 synonyms:absent in melanoma 2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="AIM2"/> <bbox w="80.0" h="50.0" x="11055.0" y="672.5"/> <glyph class="unit of information" id="_8005a7dd-73d5-451b-ac15-77ac5770ce12"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11072.5" y="667.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s8117_sa5420"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="11055.0" y="727.5"/> </glyph> </glyph> <glyph class="complex" id="s8159_csa539" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NLRC4:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NLRC4:NLRC4:PYCARD"/> <bbox w="120.0" h="145.0" x="10480.0" y="637.5"/> <glyph class="macromolecule" id="s8238_sa5408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <bbox w="80.0" h="50.0" x="10495.0" y="652.5"/> <glyph class="state variable" id="_397ef27f-db7a-4690-9df0-71f8ded91d97"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10567.5" y="647.5"/> </glyph> <glyph class="unit of information" id="_1dbcfa60-093d-4bdc-83c3-939bee17be51"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10512.5" y="647.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s8238_sa5413"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <bbox w="80.0" h="50.0" x="10505.0" y="662.5"/> <glyph class="state variable" id="_ceba88ae-d81e-4671-b36b-c9d5c6fdfb50"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10577.5" y="657.5"/> </glyph> <glyph class="unit of information" id="_e0f2e332-5520-4f60-aab6-20ecfa324d85"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10522.5" y="657.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s8116_sa5419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="10505.0" y="717.5"/> </glyph> </glyph> <glyph class="complex" id="s8161_csa538" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NLRP3:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NLRP3:NLRP3:PYCARD"/> <bbox w="117.5" h="140.0" x="10757.5" y="646.25"/> <glyph class="macromolecule" id="s8115_sa5405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="10777.5" y="723.75"/> </glyph> <glyph class="macromolecule" id="s8162_sa5406"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRP3 synonyms:NOD-like Receptor protein 3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27439607 References_end </body> </html> </notes> <label text="NLRP3"/> <bbox w="80.0" h="50.0" x="10767.5" y="658.75"/> <glyph class="unit of information" id="_064d83b3-19a6-48d9-b02d-f4c3a87d9f2c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10785.0" y="653.75"/> </glyph> </glyph> <glyph class="macromolecule" id="s8162_sa5411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NLRC4:NLRC4"/> <bbox w="113.75" h="98.75" x="10313.125" y="640.625"/> <glyph class="macromolecule" id="s8237_sa5441"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <bbox w="80.0" h="50.0" x="10323.125" y="655.625"/> <glyph class="state variable" id="_730ff8fc-11b6-4435-b206-2a5a08141de3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10395.625" y="650.625"/> </glyph> 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</body> </html> </notes> <label text="NLRP3 activators"/> <bbox w="110.0" h="25.0" x="10815.0" y="177.5"/> </glyph> <glyph class="complex" id="s8199_csa547" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NLRC4:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NLRC4:PYCARD"/> <bbox w="100.0" h="140.0" x="10660.0" y="380.0"/> <glyph class="macromolecule" id="s8197_sa5451"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="10670.0" y="450.0"/> </glyph> <glyph class="macromolecule" id="s8198_sa5461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <bbox w="80.0" h="50.0" x="10670.0" y="395.0"/> <glyph class="state variable" id="_120bfa41-38cc-4387-ac9d-f438c1b4470c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10745.0" y="390.0"/> </glyph> <glyph class="unit of information" id="_16559639-c21e-406f-bcd0-205817e3ba33"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10687.5" y="390.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s8200_csa548" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NLRP3:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NLRP3:PYCARD"/> <bbox w="100.0" h="140.0" x="10880.0" y="410.0"/> <glyph class="macromolecule" id="s8193_sa5455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="10890.0" y="480.0"/> </glyph> <glyph class="macromolecule" id="s8194_sa5459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRP3 synonyms:NOD-like Receptor protein 3 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27439607 References_end </body> </html> </notes> <label text="NLRP3"/> <bbox w="80.0" h="50.0" x="10890.0" y="425.0"/> <glyph class="unit of information" id="_7b3d5b81-9f68-4736-af19-bf20bb63dd8a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10907.5" y="420.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s8201_csa546" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AIM2:PYCARD Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="AIM2:PYCARD"/> <bbox w="100.0" h="140.0" x="11170.0" y="440.0"/> <glyph class="macromolecule" id="s8189_sa5447"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PYD and CARD domain containing HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3 synonyms:ASC Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:27984721 Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms. References_end </body> </html> </notes> <label text="PYCARD"/> <bbox w="80.0" h="40.0" x="11180.0" y="510.0"/> </glyph> <glyph class="macromolecule" id="s8190_sa5457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:AIM2 synonyms:absent in melanoma 2 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="AIM2"/> <bbox w="80.0" h="50.0" x="11180.0" y="455.0"/> <glyph class="unit of information" id="_8bd3eee4-f89b-4835-9a6b-61e1cbfd5f2e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11197.5" y="450.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s8202_csa549" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LF*:PA* Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: LeTx consists of two subunits: the protective antigen (PA) subunit attaches to plasma membranebound and assists in cytosolic translocation of the zinc metalloproteinase subunit lethal factor (LF) PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="LeTx"/> <bbox w="80.0" h="90.0" x="10160.0" y="75.0"/> <glyph class="simple chemical" id="s8203_sa5463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: protective antigen of Bacillus anthracis lethal toxin Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="PA*"/> <bbox w="70.0" h="25.0" x="10165.0" y="82.5"/> </glyph> <glyph class="simple chemical" id="s8204_sa5464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: lethal factor of Bacillus anthracis lethal toxin Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="LF*"/> <bbox w="70.0" h="25.0" x="10165.0" y="112.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s8207_sa5467" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: lethal factor of Bacillus anthracis lethal toxin Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="LF*"/> <bbox w="70.0" h="25.0" x="10065.0" y="187.5"/> </glyph> <glyph class="simple chemical" id="s8206_sa5466" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: lethal factor of Bacillus anthracis lethal toxin Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="LF*"/> <bbox w="70.0" h="25.0" x="10065.0" y="287.5"/> </glyph> <glyph class="simple chemical" id="s8205_sa5465" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protective antigen of Bacillus anthracis lethal toxin Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="PA*"/> <bbox w="70.0" h="25.0" x="10165.0" y="217.5"/> </glyph> <glyph class="macromolecule" id="s8209_sa5397" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:NLRC4 synonyms:NLR family, CARD domain containing 4 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23940371 References_end </body> </html> </notes> <label text="NLRC4"/> <bbox w="80.0" h="50.0" x="10420.0" y="465.0"/> <glyph class="state variable" id="_3383ecbd-0b35-4102-896b-9673b17a252c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10492.5" y="460.0"/> </glyph> <glyph class="unit of information" id="_abed5347-6dec-4513-b6cc-431dc05b1d1a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10437.5" y="460.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s8210_sa5471" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Flagellin*"/> <bbox w="70.0" h="25.0" x="10305.0" y="167.5"/> </glyph> <glyph class="phenotype" id="s8212_sa5473" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Gram-negative bacteria"/> <bbox w="140.0" h="25.0" x="10500.0" y="87.5"/> </glyph> <glyph class="phenotype" id="s8213_sa5474" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text=" bacterial flagellum"/> <bbox w="120.0" h="25.0" x="10280.0" y="87.5"/> </glyph> <glyph class="simple chemical" id="s8214_sa5475" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: bacterial type III secretion systems (T3SS) Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:23940371 plays an important role in host defense against Salmonella entericaserovar Typhimurium (S.Typhimurium), Legionella pneumophila, Pseudomonas aeruginosa, Shigella flexneri, and Burkholderia thailandensis References_end </body> </html> </notes> <label text="T3SS*"/> <bbox w="70.0" h="25.0" x="10535.0" y="257.5"/> </glyph> <glyph class="simple chemical" id="s8215_sa5476" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Flagellin*"/> <bbox w="70.0" h="25.0" x="10305.0" y="257.5"/> </glyph> <glyph class="complex" id="s8217_csa550" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Flagellin*:NAIP Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NAIP:Flagellin*"/> <bbox w="100.0" h="120.0" x="10290.0" y="320.0"/> <glyph class="simple chemical" id="s8218_sa5478"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Flagellin*"/> <bbox w="70.0" h="25.0" x="10305.0" y="387.5"/> </glyph> <glyph class="macromolecule" id="s8219_sa5479"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, apoptosis inhibitory protein HUGO:NAIP HGNC:7634 ENTREZ:4671 UNIPROT:Q13075 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:23940371 humans express different isoforms from a single NAIP gene that detect flagellin and T3SS components, respectively References_end </body> </html> </notes> <label text="NAIP"/> <bbox w="80.0" h="40.0" x="10300.0" y="330.0"/> </glyph> </glyph> <glyph class="complex" id="s8220_csa551" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NAIP:T3SS* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="NAIP:T3SS*"/> <bbox w="100.0" h="120.0" x="10520.0" y="320.0"/> <glyph class="macromolecule" id="s8221_sa5470"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NLR family, apoptosis inhibitory protein HUGO:NAIP HGNC:7634 ENTREZ:4671 UNIPROT:Q13075 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:23940371 humans express different isoforms from a single NAIP gene that detect flagellin and T3SS components, respectively References_end </body> </html> </notes> <label text="NAIP"/> <bbox w="80.0" h="40.0" x="10530.0" y="330.0"/> </glyph> <glyph class="simple chemical" id="s8222_sa5477"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: bacterial type III secretion systems (T3SS) Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:23940371 plays an important role in host defense against Salmonella entericaserovar Typhimurium (S.Typhimurium), Legionella pneumophila, Pseudomonas aeruginosa, Shigella flexneri, and Burkholderia thailandensis References_end </body> </html> </notes> <label text="T3SS*"/> <bbox w="70.0" h="25.0" x="10535.0" y="387.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s8239_sa5482" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: double-stranded DNA Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:25774716 References_end </body> </html> </notes> <label text="dsDNA*"/> <bbox w="70.0" h="25.0" x="11065.0" y="377.5"/> </glyph> <glyph class="phenotype" id="s8241_sa5483" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Cytomegalovirus and Influenza virus"/> <bbox w="215.0" h="22.5" x="10945.0" y="97.5"/> </glyph> <glyph class="phenotype" id="s8242_sa5484" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 References_end </body> </html> </notes> <label text="Francisella tularensis"/> <bbox w="140.0" h="25.0" x="11100.0" y="147.5"/> </glyph> <glyph class="macromolecule" id="s8243_sa5485" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Guanylate-binding protein 2 HUGO:GBP2 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:25774716 these two GBPs targeted cytosolic F. novicida and promoted bacteriolysis References_end </body> </html> </notes> <label text="GBP2"/> <bbox w="80.0" h="40.0" x="11000.0" y="230.0"/> </glyph> <glyph class="macromolecule" id="s8244_sa5486" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: Guanylate-binding protein 5 HUGO:GBP5 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:25774716 these two GBPs targeted cytosolic F. novicida and promoted bacteriolysis References_end </body> </html> </notes> <label text="GBP5"/> <bbox w="80.0" h="40.0" x="11000.0" y="280.0"/> </glyph> <glyph class="simple chemical" id="s8247_sa5493" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TcdB cytotxin* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="TcdB cytotxin*"/> <bbox w="70.0" h="25.0" x="11805.0" y="137.5"/> </glyph> <glyph class="macromolecule" id="s8255_sa5490" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras homolog family member A HUGO:RHOA hgnc_id:HGNC:667 HGNC:667 ENTREZ:387 UNIPROT:P61586 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Pyrin does not directly recognize Rho modification, but probably senses an event downstream of Rho modification in the actin cytoskeleton pathway References_end </body> </html> </notes> <label text="RHO*"/> <bbox w="80.0" h="40.0" x="11730.0" y="430.0"/> <glyph class="state variable" id="_2e3b776b-03ed-4ccd-a69f-2723d2fe6772"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11765.0" y="425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8257_sa5491" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras homolog family member A HUGO:RHOA hgnc_id:HGNC:667 HGNC:667 ENTREZ:387 UNIPROT:P61586 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Pyrin does not directly recognize Rho modification, but probably senses an event downstream of Rho modification in the actin cytoskeleton pathway References_end </body> </html> </notes> <label text="RHO*"/> <bbox w="80.0" h="40.0" x="11790.0" y="530.0"/> <glyph class="state variable" id="_d5365e5c-dba2-4d83-ac92-2186a6a7a60f"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="11822.5" y="525.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s8211_sa5472" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: bacterial type IV secretion systems (T6SS) Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Burkholderia cenocepaciainactivates RHOA by deamidating Asn 41 References_end </body> </html> </notes> <label text="T6SS*"/> <clone/> <bbox w="70.0" h="25.0" x="10535.0" y="167.5"/> </glyph> <glyph class="simple chemical" id="s8211_sa5492" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: bacterial type IV secretion systems (T6SS) Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Burkholderia cenocepaciainactivates RHOA by deamidating Asn 41 References_end </body> </html> </notes> <label text="T6SS*"/> <clone/> <bbox w="70.0" h="25.0" x="11555.0" y="147.5"/> </glyph> <glyph class="simple chemical" id="s8260_sa5489" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TcdB cytotxin* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="TcdB cytotxin*"/> <bbox w="70.0" h="25.0" x="11805.0" y="247.5"/> </glyph> <glyph class="phenotype" id="s8261_sa5494" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="Clostridium difficile"/> <bbox w="130.0" h="25.0" x="11775.0" y="67.5"/> </glyph> <glyph class="macromolecule" id="s8267_sa5499" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras homolog family member A HUGO:RHOA hgnc_id:HGNC:667 HGNC:667 ENTREZ:387 UNIPROT:P61586 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Pyrin does not directly recognize Rho modification, but probably senses an event downstream of Rho modification in the actin cytoskeleton pathway References_end </body> </html> </notes> <label text="RHOA"/> <bbox w="80.0" h="40.0" x="11730.0" y="340.0"/> </glyph> <glyph class="macromolecule" id="s8268_sa5498" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras homolog family member A HUGO:RHOA hgnc_id:HGNC:667 HGNC:667 ENTREZ:387 UNIPROT:P61586 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Pyrin does not directly recognize Rho modification, but probably senses an event downstream of Rho modification in the actin cytoskeleton pathway References_end </body> </html> </notes> <label text="RHO*"/> <bbox w="80.0" h="40.0" x="11640.0" y="530.0"/> <glyph class="state variable" id="_6e372ff9-11c3-4551-adda-a974030d9993"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="11672.5" y="525.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s8270_sa5501" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: IbpA* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="IbpA*"/> <bbox w="70.0" h="25.0" x="11395.0" y="147.5"/> </glyph> <glyph class="simple chemical" id="s8269_sa5500" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VopS* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="VopS*"/> <bbox w="70.0" h="25.0" x="11685.0" y="177.5"/> </glyph> <glyph class="simple chemical" id="s8271_sa5502" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C3 toxin* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="C3 toxin*"/> <bbox w="70.0" h="25.0" x="11255.0" y="147.5"/> </glyph> <glyph class="phenotype" id="s8272_sa5503" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="Clostridium botulinum"/> <bbox w="130.0" h="25.0" x="11220.0" y="75.0"/> </glyph> <glyph class="phenotype" id="s8273_sa5504" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="Vibrio parahaemolyticus"/> <bbox w="150.0" h="25.0" x="11645.0" y="107.5"/> </glyph> <glyph class="phenotype" id="s8274_sa5505" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="Histophilus somni"/> <bbox w="120.0" h="25.0" x="11370.0" y="75.0"/> </glyph> <glyph class="phenotype" id="s8245_sa5487" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="Burkholderia cenocepacia"/> <bbox w="165.0" h="21.25" x="11505.0" y="78.75"/> </glyph> <glyph class="macromolecule" id="s8275_sa5506" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras homolog family member A HUGO:RHOA hgnc_id:HGNC:667 HGNC:667 ENTREZ:387 UNIPROT:P61586 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Pyrin does not directly recognize Rho modification, but probably senses an event downstream of Rho modification in the actin cytoskeleton pathway References_end </body> </html> </notes> <label text="RHO*"/> <bbox w="80.0" h="40.0" x="11590.0" y="430.0"/> <glyph class="state variable" id="_8eb5b25c-2b04-4bee-8e31-0718bde9403c"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="11620.0" y="425.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s8276_sa5508" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:48584 synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="ADP-ribose*"/> <bbox w="70.0" h="25.0" x="11615.0" y="667.5"/> </glyph> <glyph class="simple chemical" id="s8277_sa5509" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:17154 synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="nicotinamide"/> <bbox w="70.0" h="25.0" x="11605.0" y="757.5"/> </glyph> <glyph class="complex" id="s8279_csa552" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ADP-ribose*:RHO* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="RHO*:ADP-ribose*"/> <bbox w="100.0" h="120.0" x="11760.0" y="620.0"/> <glyph class="macromolecule" id="s8280_sa5511"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: ras homolog family member A HUGO:RHOA hgnc_id:HGNC:667 HGNC:667 ENTREZ:387 UNIPROT:P61586 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Pyrin does not directly recognize Rho modification, but probably senses an event downstream of Rho modification in the actin cytoskeleton pathway References_end </body> </html> </notes> <label text="RHO*"/> <bbox w="80.0" h="40.0" x="11770.0" y="640.0"/> <glyph class="state variable" id="_209b1428-3b12-460d-a43e-9a5ae41ac3d3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11805.0" y="635.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s8281_sa5512"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: CHEBI:48584 synonyms:Mediterranean fever, pyrin Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:24919149 PMID:27066895 References_end </body> </html> </notes> <label text="ADP-ribose*"/> <bbox w="70.0" h="25.0" x="11775.0" y="687.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s8282_sa5513" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C3 toxin* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="C3 toxin*"/> <bbox w="70.0" h="25.0" x="11255.0" y="247.5"/> </glyph> <glyph class="simple chemical" id="s8283_sa5514" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: IbpA* Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="IbpA*"/> <bbox w="70.0" h="25.0" x="11395.0" y="247.5"/> </glyph> <glyph class="simple chemical" id="s8284_sa5515" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: bacterial type IV secretion systems (T6SS) Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:24919149 Burkholderia cenocepaciainactivates RHOA by deamidating Asn 41 References_end </body> </html> </notes> <label text="T6SS*"/> <bbox w="70.0" h="25.0" x="11555.0" y="247.5"/> </glyph> <glyph class="simple chemical" id="s8285_sa5516" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Flagellin of bacterial flagelium Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 PMID:23702978 PMID:24919149 References_end </body> </html> </notes> <label text="VopS*"/> <bbox w="70.0" h="25.0" x="11685.0" y="257.5"/> </glyph> <glyph class="complex" id="s8286_csa553" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GSDMD Identifiers_end </body> </html> </notes> <label text="GSDMD~olligomerized"/> <bbox w="120.0" h="120.0" x="10230.0" y="810.0"/> <glyph class="macromolecule" id="s8287_sa5517"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 GSDMD cleavage is sufficent to induce Pyroptosis PMID:27066895 References_end </body> </html> </notes> <label text="GSDMD"/> <bbox w="80.0" h="40.0" x="10240.0" y="820.0"/> </glyph> <glyph class="macromolecule" id="s8287_sa5518"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 GSDMD cleavage is sufficent to induce Pyroptosis PMID:27066895 References_end </body> </html> </notes> <label text="GSDMD"/> <bbox w="80.0" h="40.0" x="10250.0" y="830.0"/> </glyph> <glyph class="macromolecule" id="s8287_sa5519"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: caspase 1 HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466 Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 GSDMD cleavage is sufficent to induce Pyroptosis PMID:27066895 References_end </body> </html> </notes> <label text="GSDMD"/> <bbox w="76.42857" h="50.0" x="10260.0" y="840.0"/> </glyph> </glyph> <glyph class="phenotype" id="s8288_sa5522" compartmentRef="c45_ca50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Pyroptosis Identifiers_end Maps_Modules_begin: MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 the amino-terminal gasdermin D domain may oligomerize to form a membrane pore akin to how MLKL may act during necroptosis [80, 81]. Alternatively, the pyroptotic gasdermin D domain may induce cell lysis indirectly by damaging intracellular organelles that result in disruption of mitochondrial respiration and ATP synthesis PMID:27066895 References_end </body> </html> </notes> <label text="modulaton of ion fluxes"/> <bbox w="130.0" h="25.0" x="10095.0" y="997.5"/> </glyph> <glyph class="macromolecule" id="s8289_sa5523" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transient receptor potential cation channel subfamily C member 1 HUGO:TRPC1 hgnc_id:HGNC:12333 HGNC:12333 ENTREZ:7220 UNIPROT:P48995 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:27048821 References_end </body> </html> </notes> <label text="TRPC1"/> <bbox w="80.0" h="50.0" x="10480.0" y="1145.0"/> <glyph class="unit of information" id="_8b56a71d-7997-4b8e-9eda-dd6f543fc4b1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10497.5" y="1140.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8290_sa5524" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: transient receptor potential cation channel subfamily C member 1 HUGO:TRPC1 hgnc_id:HGNC:12333 HGNC:12333 ENTREZ:7220 UNIPROT:P48995 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:27048821 References_end </body> </html> </notes> <label text="cleaved~TRPC1"/> <bbox w="80.0" h="40.0" x="10480.0" y="1240.0"/> <glyph class="unit of information" id="_2b6b9246-f4fd-461f-b37b-0180592084d7"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10495.0" y="1235.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8291_sa5525" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: interleukin 1 alpha HUGO:IL1A hgnc_id:HGNC:5991 HGNC:5991 ENTREZ:3552 UNIPROT:P01583 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:27048821 References_end </body> </html> </notes> <label text="IL1A"/> <bbox w="80.0" h="40.0" x="11760.0" y="1110.0"/> </glyph> <glyph class="macromolecule" id="s8292_sa5526" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: high mobility group box 1 HUGO:HMGB1 hgnc_id:HGNC:4983 HGNC:4983 ENTREZ:3146 UNIPROT:P09429 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:27048821 References_end </body> </html> </notes> <label text="HMGB1"/> <bbox w="80.0" h="40.0" x="11760.0" y="1160.0"/> </glyph> <glyph class="macromolecule" id="s8293_sa5527" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: interleukin 1 alpha HUGO:IL1A hgnc_id:HGNC:5991 HGNC:5991 ENTREZ:3552 UNIPROT:P01583 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:27048821 References_end </body> </html> </notes> <label text="IL1A"/> <bbox w="80.0" h="40.0" x="11910.0" y="1110.0"/> </glyph> <glyph class="macromolecule" id="s8294_sa5528" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: high mobility group box 1 HUGO:HMGB1 hgnc_id:HGNC:4983 HGNC:4983 ENTREZ:3146 UNIPROT:P09429 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:19931333 PMID:26618107 PMID:27048821 References_end </body> </html> </notes> <label text="HMGB1"/> <bbox w="80.0" h="40.0" x="11910.0" y="1160.0"/> </glyph> <glyph class="macromolecule" id="s8295_sa5529" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:IL18 synonyms:interleukin 18 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="IL18"/> <bbox w="80.0" h="40.0" x="11910.0" y="1260.0"/> </glyph> <glyph class="macromolecule" id="s8296_sa5530" compartmentRef="c17_ca17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:IL1B synonyms:interleukin 1 beta Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS MODULE:PYROPTOSIS Maps_Modules_end References_begin: PMID:26885855 PMID:27048821 PMID:27066895 References_end </body> </html> </notes> <label text="IL1B"/> <bbox w="80.0" h="40.0" x="11910.0" y="1210.0"/> </glyph> <glyph class="phenotype" id="s8297_sa5531" compartmentRef="c17_ca17"> <label text="Potassium efflux"/> <bbox w="90.0" h="25.0" x="10830.0" y="75.0"/> </glyph> <glyph class="macromolecule" id="s8298_sa5532" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:CTSD HGNC:2529 ENTREZ:1509 UNIPROT:P07339 HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 Identifiers_end Maps_Modules_begin: MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:18955971 References_end </body> </html> </notes> <label text="Cathepsin*"/> <bbox w="80.0" h="40.0" x="3400.0" y="2330.0"/> </glyph> <glyph class="macromolecule" id="s8299_sa1855" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: G1 to S phase transition 1 HUGO:GSPT1 HGNC:4621 ENTREZ:2935 UNIPROT:P15170 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:CASPASES Maps_Modules_end </body> </html> </notes> <label text="cleaved~GSPT1*"/> <bbox w="80.0" h="40.0" x="7300.0" y="3200.0"/> <glyph class="unit of information" id="_548c1400-5c88-4d49-b0ec-1217e29c5a9a"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7315.0" y="3195.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s8300_sa5533" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: twinkle mtDNA helicase HUGO:TWNK hgnc_id:HGNC:1160 HGNC:1160 ENTREZ:56652 UNIPROT:Q96RR1 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:MITOCHONDRIAL_GENES MODULE:MITOCHONDRIAL_METABOLISM MODULE:PYROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="MT-DNA*"/> <bbox w="70.0" h="25.0" x="4035.0" y="5497.5"/> </glyph> <glyph class="simple chemical" id="s8303_sa5223" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:72080 Identifiers_end Maps_Modules_begin: MODULE:PARTHANATOS MODULE:DNA_DAMAGE_RESPONSE Maps_Modules_end References_begin: PMID:22421439 PMID:28645028 References_end </body> </html> </notes> <label text="Phosphatidylserine"/> <bbox w="145.0" h="32.5" x="2027.5" y="8103.75"/> </glyph> <glyph class="simple chemical" id="s8325_sa3421" compartmentRef="c5_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:18420 Identifiers_end </body> </html> </notes> <label text="Mg2+"/> <bbox w="25.0" h="25.0" x="1236.2631" y="6056.75"/> </glyph> <glyph class="macromolecule" id="s8336_sa5537" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 4 HUGO:PIK3R4 HGNC:8982 ENTREZ:30849 UNIPROT:Q99570 Identifiers_end Maps_Modules_begin: MODULE:STARVATION_AUTOPHAGY Maps_Modules_end </body> </html> </notes> <label text="PIK3R4"/> <bbox w="80.0" h="40.0" x="10428.5" y="2434.0"/> </glyph> <glyph class="complex" id="s7865_csa536" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TRU-TCA1-1:isopentenylation Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="TRU-TCA1-1*"/> <bbox w="173.0" h="144.0" x="9767.5" y="850.0"/> <glyph class="nucleic acid feature" id="s7866_sa5300"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TRU-TCA1-1 synonyms:tRNA(Sec) Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end References_begin: PMID:27048822 PMID:26653790 PMID:26794443 References_end </body> </html> </notes> <label text="TRU-TCA1-1"/> <bbox w="90.0" h="25.0" x="9772.5" y="867.5"/> <glyph class="unit of information" id="_d8b0c9ec-e6bf-4c3f-84c7-247603f59fbd"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="9807.5" y="862.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s8386_sa5539"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: isopentenyl diphosphate CHEBI:16584 Identifiers_end Maps_Modules_begin: MODULE:ANTIOXIDANT_RESPONSE MODULE:FERROPTOSIS Maps_Modules_end </body> </html> </notes> <label text="isopentenyl diphosphate"/> <bbox w="155.0" h="22.5" x="9776.5" y="918.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8387_sa5541" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: inositol 1,4,5-trisphosphate receptor type 1 HUGO:ITPR1 hgnc_id:HGNC:6180 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 inositol 1,4,5-trisphosphate receptor type 2 HUGO:ITPR2 hgnc_id:HGNC:6181 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 inositol 1,4,5-trisphosphate receptor type 3 HUGO:ITPR3 hgnc_id:HGNC:6182 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 Identifiers_end Maps_Modules_begin: MODULE:ER_STRESS Maps_Modules_end References_begin: PMID:23850759 References_end </body> </html> </notes> <label text="ITPR*"/> <bbox w="80.0" h="50.0" x="8532.5" y="5034.0"/> <glyph class="unit of information" id="_8ac64eba-0cc9-49c6-b865-e8f6f6c84870"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8550.0" y="5029.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s8388_sa5542" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <bbox w="80.0" h="40.0" x="8529.5" y="5089.0"/> </glyph> <glyph class="complex" id="s8389_csa381" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ANT*:PTPC ALT_NAME:ANT*:PPID:VDAC*:HK*:CK*TSPO synonyms:Permeability Transition Pore Complex Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:FERROPTOSIS MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:18309324 References_end </body> </html> </notes> <label text="PTPC"/> <clone/> <bbox w="260.0" h="230.0" x="5890.0" y="4040.0"/> <glyph class="macromolecule" id="s8390_sa3752"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <clone/> <bbox w="80.0" h="40.0" x="6050.0" y="4160.0"/> </glyph> <glyph class="macromolecule" id="s8391_sa3753"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peptidylprolyl isomerase D HUGO:PPID HGNC:9257 ENTREZ:5481 UNIPROT:Q08752 synonyms:cyclophilin D, cypD Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: peptidylprolyl isomerase D PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="PPID"/> <clone/> <bbox w="80.0" h="40.0" x="5930.0" y="4200.0"/> </glyph> <glyph class="macromolecule" id="s8392_sa3754"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 HUGO:SLC25A4 HGNC:10990 ENTREZ:291 UNIPROT:P12235 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 HUGO:SLC25A5 HGNC:10991 ENTREZ:292 UNIPROT:P05141 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 HUGO:SLC25A6 HGNC:10992 ENTREZ:293 UNIPROT:P12236 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="ANT*"/> <clone/> <bbox w="80.0" h="40.0" x="5970.0" y="4160.0"/> </glyph> <glyph class="macromolecule" id="s8390_sa3758"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <clone/> <bbox w="80.0" h="40.0" x="6050.0" y="4100.0"/> </glyph> <glyph class="macromolecule" id="s8392_sa3759"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 HUGO:SLC25A4 HGNC:10990 ENTREZ:291 UNIPROT:P12235 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 HUGO:SLC25A5 HGNC:10991 ENTREZ:292 UNIPROT:P05141 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 HUGO:SLC25A6 HGNC:10992 ENTREZ:293 UNIPROT:P12236 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="ANT*"/> <clone/> <bbox w="80.0" h="40.0" x="5970.0" y="4100.0"/> </glyph> <glyph class="macromolecule" id="s8393_sa5365"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: C-C motif chemokine ligand 19 HUGO:CCL19 hgnc_id:HGNC:10617 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="CK*"/> <clone/> <bbox w="80.0" h="40.0" x="6050.0" y="4050.0"/> </glyph> <glyph class="macromolecule" id="s8394_sa5370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hexokinase 1 HUGO:HK1 hgnc_id:HGNC:4922 HGNC:4922 ENTREZ:3098 UNIPROT:P19367 hexokinase 2 HUGO:HK2 hgnc_id:HGNC:4923 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK*"/> <clone/> <bbox w="80.0" h="40.0" x="5970.0" y="4050.0"/> </glyph> <glyph class="macromolecule" id="s8395_sa5373"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TPSO synonyms:peripheral benzodiazepine receptor,PBR Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="TSPO"/> <clone/> <bbox w="80.0" h="50.0" x="6040.0" y="4205.0"/> <glyph class="unit of information" id="_ee94f1f9-c16b-4b22-b779-8434db0e1347"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6057.5" y="4200.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s8389_csa382" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ANT*:PTPC ALT_NAME:ANT*:PPID:VDAC*:HK*:CK*TSPO synonyms:Permeability Transition Pore Complex Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:FERROPTOSIS MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:18309324 References_end </body> </html> </notes> <label text="PTPC"/> <clone/> <bbox w="260.0" h="250.0" x="5890.0" y="4370.0"/> <glyph class="macromolecule" id="s8390_sa3760"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <clone/> <bbox w="80.0" h="40.0" x="6050.0" y="4490.0"/> </glyph> <glyph class="macromolecule" id="s8391_sa3761"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: peptidylprolyl isomerase D HUGO:PPID HGNC:9257 ENTREZ:5481 UNIPROT:Q08752 synonyms:cyclophilin D, cypD Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: peptidylprolyl isomerase D PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="PPID"/> <clone/> <bbox w="80.0" h="40.0" x="5920.0" y="4535.0"/> </glyph> <glyph class="macromolecule" id="s8392_sa3762"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 HUGO:SLC25A4 HGNC:10990 ENTREZ:291 UNIPROT:P12235 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 HUGO:SLC25A5 HGNC:10991 ENTREZ:292 UNIPROT:P05141 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 HUGO:SLC25A6 HGNC:10992 ENTREZ:293 UNIPROT:P12236 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="ANT*"/> <clone/> <bbox w="80.0" h="40.0" x="5970.0" y="4490.0"/> </glyph> <glyph class="macromolecule" id="s8390_sa3763"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: voltage-dependent anion channel 1 HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796 voltage-dependent anion channel 2 HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880 voltage-dependent anion channel 3 HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MOMP_REGULATION MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:NECROPTOSIS Maps_Modules_end References_begin: PMID:21887410 PMID:18309324 PMID:17568748 References_end </body> </html> </notes> <label text="VDAC*"/> <clone/> <bbox w="80.0" h="40.0" x="6050.0" y="4430.0"/> </glyph> <glyph class="macromolecule" id="s8392_sa3764"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 HUGO:SLC25A4 HGNC:10990 ENTREZ:291 UNIPROT:P12235 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 HUGO:SLC25A5 HGNC:10991 ENTREZ:292 UNIPROT:P05141 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 HUGO:SLC25A6 HGNC:10992 ENTREZ:293 UNIPROT:P12236 Identifiers_end Maps_Modules_begin: MODULE:APOPTOSIS MODULE:DEATH_RECEPTOR_PATHWAYS MODULE:MITOCHONDRIAL_METABOLISM MODULE:MOMP_REGULATION MODULE:NECROPTOSIS MODULE:OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION Maps_Modules_end References_begin: PMID:20823910 PMID:18309324 References_end </body> </html> </notes> <label text="ANT*"/> <clone/> <bbox w="80.0" h="40.0" x="5970.0" y="4430.0"/> </glyph> <glyph class="macromolecule" id="s8393_sa5366"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: C-C motif chemokine ligand 19 HUGO:CCL19 hgnc_id:HGNC:10617 HGNC:10617 ENTREZ:6363 UNIPROT:Q99731 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="CK*"/> <clone/> <bbox w="80.0" h="40.0" x="6050.0" y="4380.0"/> </glyph> <glyph class="macromolecule" id="s8394_sa5371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: hexokinase 1 HUGO:HK1 hgnc_id:HGNC:4922 HGNC:4922 ENTREZ:3098 UNIPROT:P19367 hexokinase 2 HUGO:HK2 hgnc_id:HGNC:4923 HGNC:4923 ENTREZ:3099 UNIPROT:P52789 Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="HK*"/> <clone/> <bbox w="80.0" h="40.0" x="5970.0" y="4380.0"/> </glyph> <glyph class="macromolecule" id="s8395_sa5374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body> Identifiers_begin: HUGO:TPSO synonyms:peripheral benzodiazepine receptor,PBR Identifiers_end Maps_Modules_begin: MODULE:MITOCHONDRIAL_PERMEABILITY_TRANSITION MODULE:MOMP_REGULATION Maps_Modules_end References_begin: PMID:15033708 PMID:18309324 PMID:25486353 References_end </body> </html> </notes> <label text="TSPO"/> <clone/> <bbox w="80.0" h="50.0" x="6050.0" y="4545.0"/> <glyph class="unit of information" id="_28e89683-5936-4c8c-8444-99ce5b1dc9a0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6067.5" y="4540.0"/> </glyph> </glyph> </glyph> <glyph class="process" orientation="horizontal" id="pr_5f4c82e7-3b83-45e2-8b0e-7a2b12a4d9e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5206.834" y="5002.0"/> <port id="pr_5f4c82e7-3b83-45e2-8b0e-7a2b12a4d9e7_p1" x="5196.834" y="5007.0"/> <port id="pr_5f4c82e7-3b83-45e2-8b0e-7a2b12a4d9e7_p2" x="5226.834" y="5007.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e4ad210c-f1ef-4140-9cf0-d17c0b3d0c6b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP PMID:14532003 PMID:10929711 PMID:12660240 in Hela upn taxol treatment References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5637.5" y="3833.0"/> <port id="pr_e4ad210c-f1ef-4140-9cf0-d17c0b3d0c6b_p1" x="5627.5" y="3838.0"/> <port id="pr_e4ad210c-f1ef-4140-9cf0-d17c0b3d0c6b_p2" x="5657.5" y="3838.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_019386c7-3f04-4e8b-ace1-dbdc91f66b0b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP PMID:11803371 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5147.474" y="4325.284"/> <port id="pr_019386c7-3f04-4e8b-ace1-dbdc91f66b0b_p1" x="5137.474" y="4330.284"/> <port id="pr_019386c7-3f04-4e8b-ace1-dbdc91f66b0b_p2" x="5167.474" y="4330.284"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9a479a90-ba76-4fed-b3f8-6c3a83eb7a53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8879205 release of AIF is blocked by BCL2 overexpression but data supporting direct involvment of MOMP not found in the literature References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5136.474" y="3624.3755"/> <port id="pr_9a479a90-ba76-4fed-b3f8-6c3a83eb7a53_p1" x="5126.474" y="3629.3755"/> <port id="pr_9a479a90-ba76-4fed-b3f8-6c3a83eb7a53_p2" x="5156.474" y="3629.3755"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_653b6343-1246-45b6-afab-afb14e44f34d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP PMID:9892620 PMID:10318956 PMID:12611882 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5342.974" y="4789.341"/> <port id="pr_653b6343-1246-45b6-afab-afb14e44f34d_p1" x="5332.974" y="4794.341"/> <port id="pr_653b6343-1246-45b6-afab-afb14e44f34d_p2" x="5362.974" y="4794.341"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fb4e9061-7234-4dd6-81b8-46760e365bad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP PMID:9508780 PMID:12611882 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6548.9683" y="5095.0"/> <port id="pr_fb4e9061-7234-4dd6-81b8-46760e365bad_p1" x="6538.9683" y="5100.0"/> <port id="pr_fb4e9061-7234-4dd6-81b8-46760e365bad_p2" x="6568.9683" y="5100.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ba073285-1ab7-42cf-a129-755b3189e74c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP PMID:9892620 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5242.0244" y="3745.0918"/> <port id="pr_ba073285-1ab7-42cf-a129-755b3189e74c_p1" x="5232.0244" y="3750.0918"/> <port id="pr_ba073285-1ab7-42cf-a129-755b3189e74c_p2" x="5262.0244" y="3750.0918"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5e249efa-25ad-440a-9636-feeb07b4e2b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: in Ba/F3 cells, stable expression of the C-terminal cleavage product of BECN1 sensitizes cells to IL3-deprivation induced apoptosis in vitro, incubation of isolated mitochondria with recombinant BECN1 C-terminal cleavage product triggers release of Omi/HtrA2 and cytochrome c PMID:11832478 in vitro CASP2 unlike CASP8 induce release of CYCS , DIABLO and AIF form purified mitochondria from Hela cellsPMID: PMID:23242420 calpain-mediated Bax and Atg5 cleavage resulted in the collapse of the mitochondrial membrane potential and cytochrome c release References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4900.7104" y="6121.0815"/> <port id="pr_5e249efa-25ad-440a-9636-feeb07b4e2b2_p1" x="4890.7104" y="6126.0815"/> <port id="pr_5e249efa-25ad-440a-9636-feeb07b4e2b2_p2" x="4920.7104" y="6126.0815"/> </glyph> <glyph class="process" orientation="vertical" id="pr_884103ea-8547-4734-a015-3a47131ff5f8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP PMID:9894606 in Jurkat References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5360.0" y="6327.5"/> <port id="pr_884103ea-8547-4734-a015-3a47131ff5f8_p1" x="5365.0" y="6317.5"/> <port id="pr_884103ea-8547-4734-a015-3a47131ff5f8_p2" x="5365.0" y="6347.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_33933331-1336-439c-8a5d-1d08c82081ef"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10950869 direct activation of BAK by tBID References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5156.692" y="5744.125"/> <port id="pr_33933331-1336-439c-8a5d-1d08c82081ef_p1" x="5176.692" y="5749.125"/> <port id="pr_33933331-1336-439c-8a5d-1d08c82081ef_p2" x="5146.692" y="5749.125"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f5042205-eca0-4112-a108-50376cd2e258"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12881569 PMID:19706873 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5403.0" y="5637.0"/> <port id="pr_f5042205-eca0-4112-a108-50376cd2e258_p1" x="5408.0" y="5627.0"/> <port id="pr_f5042205-eca0-4112-a108-50376cd2e258_p2" x="5408.0" y="5657.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5050cd81-ad44-49cd-b5cf-5d5ca2a3f3a7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18056423 in mouse liver References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5403.0" y="5885.0"/> <port id="pr_5050cd81-ad44-49cd-b5cf-5d5ca2a3f3a7_p1" x="5423.0" y="5890.0"/> <port id="pr_5050cd81-ad44-49cd-b5cf-5d5ca2a3f3a7_p2" x="5393.0" y="5890.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5c4da906-c41d-498e-b36d-d37fd8db4e3e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15486085 in FL5.12 cells correlation of BIM-BAX interaction in mitochondrial fractions with presence of unphosphorylated S65 BimEL non phosphorylatable BimEL: enhanced interaction with BAX and enhanced proapoptotic activity PMID:12419244 in vitro in reconstituted vesicles, BID induces BAX and membrane permeabilization References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4517.6055" y="5843.1855"/> <port id="pr_5c4da906-c41d-498e-b36d-d37fd8db4e3e_p1" 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porcine kidney cell line References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5980.0" y="2795.0"/> <port id="pr_5f31c8ca-45c9-4468-a07f-ff093ac8eed7_p1" x="5970.0" y="2800.0"/> <port id="pr_5f31c8ca-45c9-4468-a07f-ff093ac8eed7_p2" x="6000.0" y="2800.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ccb88757-78fe-4e1c-822d-c06115130ce2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The impact of the S284 phosphorylation status on the other reactions (phosphorylations, membrane insertion...) was not assessed. PMID:14766748 Akt-dependent phosphorylation of BAX S184 upon GM-CSF in PLB-985 human, peripheral blood, leukemia, acute myeloid in mouse peritoneal neutrophils PMID:15642728 Akt directly phosphorylates BAX S184 in response to nicotine in A549 human lung cancer cell line PMID:17525161 PRKCZ dependent phosphorylation of Bax at S184 in A549 carcinomic human alveolar basal epithelial cells exposed to nicotine References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5800.0" y="2795.0"/> <port id="pr_ccb88757-78fe-4e1c-822d-c06115130ce2_p1" x="5820.0" y="2800.0"/> <port id="pr_ccb88757-78fe-4e1c-822d-c06115130ce2_p2" x="5790.0" y="2800.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_719035c8-b72c-4419-b6c3-39d9929336f2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15642728 BAX phosphorylated on S184 in response to nicotine displays a shortened half life in A549 human lung cancer cell line PMID:10725400 proteasome dependent degradation of BAX References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5627.5" y="2795.0"/> <port id="pr_719035c8-b72c-4419-b6c3-39d9929336f2_p1" x="5647.5" y="2800.0"/> <port id="pr_719035c8-b72c-4419-b6c3-39d9929336f2_p2" x="5617.5" y="2800.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7658bdec-548c-48c1-81fd-581be8adb6d1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12652308 in HEK293 Ku70 KO in MEFs results in hypersensitivity to apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5951.375" y="2905.0"/> <port id="pr_7658bdec-548c-48c1-81fd-581be8adb6d1_p1" x="5941.375" y="2910.0"/> <port id="pr_7658bdec-548c-48c1-81fd-581be8adb6d1_p2" x="5971.375" y="2910.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_998e61bb-f28e-4e42-9b45-564e06f67d67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12732850 there is also a nuclear encoded peptide that display the same effect on BAX mediated apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5942.0" y="2665.0"/> <port id="pr_998e61bb-f28e-4e42-9b45-564e06f67d67_p1" x="5932.0" y="2670.0"/> <port id="pr_998e61bb-f28e-4e42-9b45-564e06f67d67_p2" x="5962.0" y="2670.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_63244981-89e3-4ed3-b96d-02aae63ba783"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to 14-3-3* considering that BAX cannot titrate 14-3-3 PMID:12426317 in Hela and NIH3T3, 14-3-3 binds to non phosphorylated BAX. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5982.0" y="3055.0"/> <port id="pr_63244981-89e3-4ed3-b96d-02aae63ba783_p1" x="5972.0" y="3060.0"/> <port id="pr_63244981-89e3-4ed3-b96d-02aae63ba783_p2" x="6002.0" y="3060.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dfef82a8-b8f4-4088-aa27-4cc2a8cd9a12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP reactionType:casp.cleavage PMID:12426317 zVAD-fmk inhibits YWHAQ and YWHAE but not YWHAZ cleavage and dissociation from BAX PMID:15071501 putative cleavage sites in YWHAB, YWHAG, YWHAE, YWHAQ, SFN absent in YWHAQ PMID:12657644 YWHAE cleaved by CASP3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7627.289" y="4928.2334"/> <port id="pr_dfef82a8-b8f4-4088-aa27-4cc2a8cd9a12_p1" x="7617.289" y="4933.2334"/> <port id="pr_dfef82a8-b8f4-4088-aa27-4cc2a8cd9a12_p2" x="7647.289" y="4933.2334"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7c636286-e318-4582-a2f6-b3b494198637"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15071501 in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7553.995" y="4861.9395"/> <port id="pr_7c636286-e318-4582-a2f6-b3b494198637_p1" x="7558.995" y="4881.9395"/> <port id="pr_7c636286-e318-4582-a2f6-b3b494198637_p2" x="7558.995" y="4851.9395"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2fdf4534-c2e5-4c98-9c43-c1c7d800f32d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7626.294" y="4824.294"/> <port id="pr_2fdf4534-c2e5-4c98-9c43-c1c7d800f32d_p1" x="7616.294" y="4829.294"/> <port id="pr_2fdf4534-c2e5-4c98-9c43-c1c7d800f32d_p2" x="7646.294" y="4829.294"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d1384a2f-863a-4149-9d3a-7812feeece2d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7625.289" y="4891.2334"/> <port 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id="pr_172adaab-1f57-4244-afdd-dc1c170bc8f8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:7991614 in A549, in rat lung, upon hyperoxia, decreased ACO2 activity PMID:7768942 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1400.75" y="6008.25"/> <port id="pr_172adaab-1f57-4244-afdd-dc1c170bc8f8_p1" x="1390.75" y="6013.25"/> <port id="pr_172adaab-1f57-4244-afdd-dc1c170bc8f8_p2" x="1420.75" y="6013.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_83d9b3ea-32cc-47d3-9ec0-4ab82cb607cd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12198491 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19628817 SDH5 is required for SDHA flavination (inferred from yeast) SDH5 primarily soluble and localized in mitochondrial matrix (inferred from yeast) SDH5 mutation segregates with disease in a family with paraganglioma References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="887.75" y="5218.433"/> <port id="pr_c927e0aa-231c-4d15-8597-fef70711765f_p1" x="907.75" y="5223.433"/> <port id="pr_c927e0aa-231c-4d15-8597-fef70711765f_p2" x="877.75" y="5223.433"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_966f1596-c4a1-4e13-9134-e63873b1cc28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19465911 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="788.35754" y="5059.336"/> <port id="pr_966f1596-c4a1-4e13-9134-e63873b1cc28_p1" x="778.35754" y="5064.336"/> <port id="pr_966f1596-c4a1-4e13-9134-e63873b1cc28_p2" x="808.35754" y="5064.336"/> </glyph> <glyph class="process" orientation="vertical" id="pr_320f41e1-7bf9-46b3-a283-26521eaa9f8a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18485875 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="919.25" y="4439.0566"/> <port id="pr_320f41e1-7bf9-46b3-a283-26521eaa9f8a_p1" x="924.25" y="4459.0566"/> <port id="pr_320f41e1-7bf9-46b3-a283-26521eaa9f8a_p2" x="924.25" y="4429.0566"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_61826231-f502-4116-bfed-21564a047dbb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16200211 NDUFAF2 PMID:17344420 ECSIT:NDUFAF1 PMID:20816094 involvement of ACAD9 in the ECSIT:NDUFAF1 complex PMID:16218961 NDUFAF1 PMID:15526035 AIF deficient cells exhibit a decrease content of complex I. It was proposed that AIF has a role in the biogenesis or maintenance of complex I PMID:20025615 comprehensive review about complex I References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="658.42255" y="4822.9717"/> <port id="pr_61826231-f502-4116-bfed-21564a047dbb_p1" x="648.42255" y="4827.9717"/> <port id="pr_61826231-f502-4116-bfed-21564a047dbb_p2" x="678.42255" y="4827.9717"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d2c6d7bc-7256-4e0d-9ddb-2741701e508c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19131594 in mouse liver, in mouse pro-B cells, STAT3 is found in mitochondria mitochondrial STAT3 interacts with NDUFA13 mitochondrial STAT3 necessary for proper activity of complexes I and II of the electron transport chain STAT3 in mitochondria is preferentially phosphorylated on S727 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1376.4023" y="5224.9263"/> <port id="pr_d2c6d7bc-7256-4e0d-9ddb-2741701e508c_p1" x="1366.4023" y="5229.9263"/> <port id="pr_d2c6d7bc-7256-4e0d-9ddb-2741701e508c_p2" x="1396.4023" y="5229.9263"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_b2aa73b0-4cc0-40b7-8d58-3dcd52840ac2"> <bbox w="20.0" h="20.0" x="1231.0385" y="4746.991"/> <port id="logicglyph_b2aa73b0-4cc0-40b7-8d58-3dcd52840ac2_p1" x="1241.0385" y="4736.991"/> <port id="logicglyph_b2aa73b0-4cc0-40b7-8d58-3dcd52840ac2_p2" x="1241.0385" y="4776.991"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6b1a023b-05d3-4eab-a24a-d906361501a2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15807660 References_end </body> </html> </notes> <bbox w="10.0" 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class="process" orientation="vertical" id="pr_b1c6f86b-16c4-43cc-a602-4c9a40e4d366"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2092.75" y="5657.75"/> <port id="pr_b1c6f86b-16c4-43cc-a602-4c9a40e4d366_p1" x="2097.75" y="5647.75"/> <port id="pr_b1c6f86b-16c4-43cc-a602-4c9a40e4d366_p2" x="2097.75" y="5677.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_da1f584a-33a9-4a7b-a4b1-6d0c942ec542"> <bbox w="10.0" h="10.0" x="1900.75" y="5219.33"/> <port id="pr_da1f584a-33a9-4a7b-a4b1-6d0c942ec542_p1" x="1890.75" y="5224.33"/> <port id="pr_da1f584a-33a9-4a7b-a4b1-6d0c942ec542_p2" x="1920.75" y="5224.33"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_53182705-3b46-4c3e-88c5-0b2235133112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15807660 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1854.5352" y="5498.6855"/> <port id="pr_53182705-3b46-4c3e-88c5-0b2235133112_p1" x="1844.5352" y="5503.6855"/> <port id="pr_53182705-3b46-4c3e-88c5-0b2235133112_p2" x="1874.5352" y="5503.6855"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c86c0b44-4be8-4df3-8445-2d12ee9e3fe3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8194600 cytochrome oxidase inhibition by nitric oxide References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1900.75" y="5013.33"/> <port id="pr_c86c0b44-4be8-4df3-8445-2d12ee9e3fe3_p1" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17418790 Upon hypoxia, COX4I1 degraded by LONP1 is replaced into the COX complex by COX4I2, resulting in lower ROS generation and higher electron transport chain activity References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1916.75" y="4690.0"/> <port id="pr_a9fd5313-aae7-4e70-b4c3-75798fb6584d_p1" x="1936.75" y="4695.0"/> <port id="pr_a9fd5313-aae7-4e70-b4c3-75798fb6584d_p2" x="1906.75" y="4695.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4eb3f2ef-c3dd-4cfe-b242-3b7511e94378"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15119951 SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency) PMID:11389896 SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability PMID:19625251 Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2161.75" y="4865.0"/> <port id="pr_4eb3f2ef-c3dd-4cfe-b242-3b7511e94378_p1" x="2166.75" y="4885.0"/> <port id="pr_4eb3f2ef-c3dd-4cfe-b242-3b7511e94378_p2" x="2166.75" y="4855.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_353fae17-9c14-4207-8fe1-0278f6bc9772"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19503089 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2677.746" y="5466.25"/> <port id="pr_353fae17-9c14-4207-8fe1-0278f6bc9772_p1" x="2682.746" y="5486.25"/> <port id="pr_353fae17-9c14-4207-8fe1-0278f6bc9772_p2" x="2682.746" y="5456.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b834bc2e-2188-4435-9455-6f79b30bb9fb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20023629 in Hela and 293T, ectopically expressed USP9X binds and deubiquitinylates MCL1. in human follicular lymphomas, USP9X overexpression correlates with MCL1 expression. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4725.074" y="5586.0"/> <port id="pr_b834bc2e-2188-4435-9455-6f79b30bb9fb_p1" x="4715.074" y="5591.0"/> <port id="pr_b834bc2e-2188-4435-9455-6f79b30bb9fb_p2" x="4745.074" y="5591.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d4101fec-3ad3-4155-8ef1-d5b4be595cfb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10508159 CASP3 cleavage by cathepsin D as data not shown PMID:12208500 sustained activation of AMPK induces Caspase 3 cleavage and so lead to apoptosis triggering References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7275.9746" y="4315.284"/> <port id="pr_d4101fec-3ad3-4155-8ef1-d5b4be595cfb_p1" x="7265.9746" y="4320.284"/> <port id="pr_d4101fec-3ad3-4155-8ef1-d5b4be595cfb_p2" x="7295.9746" y="4320.284"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d2284c6e-ea8c-490d-ac5f-321190773552"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP reactionType:casp.cleavage PMID:8900201 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7475.0" y="4205.0"/> <port id="pr_d2284c6e-ea8c-490d-ac5f-321190773552_p1" x="7465.0" y="4210.0"/> <port id="pr_d2284c6e-ea8c-490d-ac5f-321190773552_p2" x="7495.0" y="4210.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e90404be-fa2a-4f6d-a71f-1af49fbfe669"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18056423 p53 mediated upregulation of IGFBP1 in mouse liver PMID:9707622 in HepG2, by HIF1 PMID:10102273 in 293T, by FOXO3, EMSA References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3606.4226" y="7192.7793"/> <port id="pr_e90404be-fa2a-4f6d-a71f-1af49fbfe669_p1" x="3611.4226" y="7212.7793"/> <port id="pr_e90404be-fa2a-4f6d-a71f-1af49fbfe669_p2" x="3611.4226" y="7182.7793"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a7abfde9-25a6-4516-8d2b-8cce634e9ca4"> <bbox w="10.0" h="10.0" x="3630.359" y="6979.185"/> <port id="pr_a7abfde9-25a6-4516-8d2b-8cce634e9ca4_p1" x="3635.359" y="6999.185"/> <port id="pr_a7abfde9-25a6-4516-8d2b-8cce634e9ca4_p2" x="3635.359" y="6969.185"/> </glyph> <glyph class="process" orientation="vertical" id="pr_58689857-f3c5-4bd3-b500-a85f47d313c9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12445508 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4431.6143" y="4306.75"/> <port id="pr_58689857-f3c5-4bd3-b500-a85f47d313c9_p1" x="4436.6143" y="4326.75"/> <port id="pr_58689857-f3c5-4bd3-b500-a85f47d313c9_p2" x="4436.6143" y="4296.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_50eb8915-518a-4543-a39e-31a6a006efd9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14747474 in U937 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3782.75" y="4237.9385"/> <port id="pr_50eb8915-518a-4543-a39e-31a6a006efd9_p1" x="3772.75" y="4242.9385"/> <port id="pr_50eb8915-518a-4543-a39e-31a6a006efd9_p2" x="3802.75" y="4242.9385"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_58a80667-7491-41b0-892e-46a5b317074e"> <notes> <html 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(ectopic expression, RNA interfernce) interaction takes place within mitochondria (data not shown) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3668.0" y="4049.7778"/> <port id="pr_03b26964-b2ab-4aab-8c41-3ace334d4f76_p1" x="3688.0" y="4054.7778"/> <port id="pr_03b26964-b2ab-4aab-8c41-3ace334d4f76_p2" x="3658.0" y="4054.7778"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5ac2c114-a0fd-4d4a-b0c4-0940e992a174"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14747474 in U937 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3782.974" y="4190.284"/> <port id="pr_5ac2c114-a0fd-4d4a-b0c4-0940e992a174_p1" x="3802.974" y="4195.284"/> <port id="pr_5ac2c114-a0fd-4d4a-b0c4-0940e992a174_p2" x="3772.974" y="4195.284"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_33108347-7b06-488a-add7-9cf76df71d7b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16166262 PMID:23070007 in chronic lymphocytic leukemia human cells References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4365.5195" y="6750.75"/> <port id="pr_33108347-7b06-488a-add7-9cf76df71d7b_p1" x="4355.5195" y="6755.75"/> <port id="pr_33108347-7b06-488a-add7-9cf76df71d7b_p2" x="4385.5195" y="6755.75"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_40e2f38c-b02f-41f5-82ed-6bebe0d6db05"> <bbox w="20.0" h="20.0" x="2162.3757" y="6656.411"/> <port id="logicglyph_40e2f38c-b02f-41f5-82ed-6bebe0d6db05_p1" x="2152.3757" y="6666.411"/> <port id="logicglyph_40e2f38c-b02f-41f5-82ed-6bebe0d6db05_p2" x="2192.3757" y="6666.411"/> </glyph> <glyph class="process" 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Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding also through down regulation of Sp1 PMID:19808698 in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression PMID:11160159 in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression. in NIH3T3, upon v-src, STAT3 dependent expression of MCL1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3595.6646" y="7226.496"/> <port id="pr_53e5c58d-9c08-4c9f-ba6e-a5c2904f751e_p1" x="3600.6646" y="7246.496"/> <port id="pr_53e5c58d-9c08-4c9f-ba6e-a5c2904f751e_p2" x="3600.6646" y="7216.496"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f0a88f46-5167-4ccb-b7b1-e308f2c24b66"> <bbox w="10.0" h="10.0" x="7065.0" y="4695.3574"/> <port 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<body>References_begin: PMID:7566179 in EB1 colon carninoma cells expressing p53 under the control of an inducible promoter in Saos-2 huamn osteosarcoma cells expressing a temperature sensitive p53 PMID:17409411 in mouse spleen and thymus upon irradiation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3248.635" y="7185.3086"/> <port id="pr_3f1afe52-13fc-471d-86e9-699dd5022a9a_p1" x="3253.635" y="7205.3086"/> <port id="pr_3f1afe52-13fc-471d-86e9-699dd5022a9a_p2" x="3253.635" y="7175.3086"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b49d46cf-7daf-442b-9ab4-393fbdefd96d"> <bbox w="10.0" h="10.0" x="3207.0679" y="7619.875"/> <port id="pr_b49d46cf-7daf-442b-9ab4-393fbdefd96d_p1" x="3212.0679" y="7609.875"/> <port id="pr_b49d46cf-7daf-442b-9ab4-393fbdefd96d_p2" x="3212.0679" y="7639.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_48409fbf-8bf2-4cd6-8817-18e85cb6b7b8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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<body>References_begin: PMID:18692468 PMID:12203114 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3357.21" y="7223.3086"/> <port id="pr_ec95e509-0fc9-43d5-8986-32834b735dd9_p1" x="3362.21" y="7243.3086"/> <port id="pr_ec95e509-0fc9-43d5-8986-32834b735dd9_p2" x="3362.21" y="7213.3086"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_20c9863f-577c-4808-ad78-b3a7a0e3504d"> <bbox w="10.0" h="10.0" x="5949.689" y="4641.875"/> <port id="pr_20c9863f-577c-4808-ad78-b3a7a0e3504d_p1" x="5939.689" y="4646.875"/> <port id="pr_20c9863f-577c-4808-ad78-b3a7a0e3504d_p2" x="5969.689" y="4646.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4269a78c-79d2-463f-a523-cb2719be2b2a"> <bbox w="10.0" h="10.0" x="5942.6606" y="4689.375"/> <port id="pr_4269a78c-79d2-463f-a523-cb2719be2b2a_p1" x="5932.6606" y="4694.375"/> <port id="pr_4269a78c-79d2-463f-a523-cb2719be2b2a_p2" x="5962.6606" y="4694.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_34d90536-675b-436c-b870-cca350982b82"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19203586 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3447.5645" y="7188.6836"/> <port id="pr_34d90536-675b-436c-b870-cca350982b82_p1" x="3452.5645" y="7208.6836"/> <port id="pr_34d90536-675b-436c-b870-cca350982b82_p2" x="3452.5645" y="7178.6836"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_14997449-09e5-49ba-b45e-59a937873902"> <bbox w="10.0" h="10.0" x="6106.836" y="4486.587"/> <port id="pr_14997449-09e5-49ba-b45e-59a937873902_p1" x="6096.836" y="4491.587"/> <port id="pr_14997449-09e5-49ba-b45e-59a937873902_p2" x="6126.836" y="4491.587"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f937eada-771e-42e3-98ab-2efe106b6789"> <notes> <html 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PMAIP knock down protects from apoptosis PMID:12676992 in MEF by CTBP1 and CTBP2 (RT-PCR, double knocked out) PMID:14684737 in NIH3T3, by E2F1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3440.4478" y="7223.1284"/> <port id="pr_f937eada-771e-42e3-98ab-2efe106b6789_p1" x="3445.4478" y="7243.1284"/> <port id="pr_f937eada-771e-42e3-98ab-2efe106b6789_p2" x="3445.4478" y="7213.1284"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3134bd80-d46d-4285-9d30-610113bfd66b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11463391 by p53 PMID:11463392 PMID:14634023 in Saos-2, by p73 PMID:14684737 in NIH3T3 and in Saos-2, by E2F1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3528.02" y="7192.036"/> <port id="pr_3134bd80-d46d-4285-9d30-610113bfd66b_p1" x="3533.02" y="7212.036"/> <port id="pr_3134bd80-d46d-4285-9d30-610113bfd66b_p2" x="3533.02" y="7182.036"/> </glyph> <glyph class="process" orientation="vertical" id="pr_da1226c3-194c-41bd-b2df-f459d3dd185c"> <bbox w="10.0" h="10.0" x="3520.2551" y="7226.9805"/> <port id="pr_da1226c3-194c-41bd-b2df-f459d3dd185c_p1" x="3525.2551" y="7246.9805"/> <port id="pr_da1226c3-194c-41bd-b2df-f459d3dd185c_p2" x="3525.2551" y="7216.9805"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fc97a591-98fc-4b11-9036-cc7e55899c2f"> <bbox w="10.0" h="10.0" x="4833.466" y="6032.25"/> <port id="pr_fc97a591-98fc-4b11-9036-cc7e55899c2f_p1" x="4823.466" y="6037.25"/> <port id="pr_fc97a591-98fc-4b11-9036-cc7e55899c2f_p2" x="4853.466" y="6037.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5d7b19f4-267b-441e-929c-22b25bffec82"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12402042 in mouse splenic red pulp and colonic epithelium, upon irradiation in human, the p53 binding element is conserved PMID:15024076 in HT29 and CHO, HIF1-dependent hypoxia-induced repression of BID expression in SW480 upon hypoxia, interaction between HIF1 and BID promoter, by EMSA PMID:15240700 in mouse T cells, by E2F1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3801.46" y="7204.2793"/> <port id="pr_5d7b19f4-267b-441e-929c-22b25bffec82_p1" x="3806.46" y="7224.2793"/> <port id="pr_5d7b19f4-267b-441e-929c-22b25bffec82_p2" x="3806.46" y="7194.2793"/> </glyph> <glyph class="process" orientation="vertical" id="pr_eb4c285f-4e10-471b-877c-3287acba75bb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19211844 FOXO3 mediated inhibition PMID:11714700 TP53 mediated inhibition PMID:11965534 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3832.9082" y="7204.6836"/> <port id="pr_eb4c285f-4e10-471b-877c-3287acba75bb_p1" x="3837.9082" y="7224.6836"/> <port id="pr_eb4c285f-4e10-471b-877c-3287acba75bb_p2" x="3837.9082" y="7194.6836"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2be596c5-fa35-44af-a00f-db730b9caccb"> <bbox w="10.0" h="10.0" x="5742.368" y="5401.75"/> <port id="pr_2be596c5-fa35-44af-a00f-db730b9caccb_p1" x="5732.368" y="5406.75"/> <port id="pr_2be596c5-fa35-44af-a00f-db730b9caccb_p2" x="5762.368" y="5406.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1c5e7d33-8492-4519-a187-a117b52b4ec4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17000778 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3877.7705" y="7207.036"/> <port id="pr_1c5e7d33-8492-4519-a187-a117b52b4ec4_p1" x="3882.7705" y="7227.036"/> <port id="pr_1c5e7d33-8492-4519-a187-a117b52b4ec4_p2" x="3882.7705" y="7197.036"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9c3d25f4-72a6-4fa9-a028-b3b6de8a3568"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:7834749 by p53 PMID:15613549 in HEK 293, by NFkB, upon expression of LMP1 protein (from EBV). More precisely, p65/p50 dimer inhibits BAX promoter activity whereas p50/p50 dimer is actually an transcriptional activator or BAX. However p65 has to be inhibited to see p50/p50 mediated activation of BAX PMID:12676992 in MEF double knocked out by CTBP1 and CTBP2 (RT-PCR) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3909.6104" y="7203.6836"/> <port id="pr_9c3d25f4-72a6-4fa9-a028-b3b6de8a3568_p1" x="3914.6104" y="7223.6836"/> <port id="pr_9c3d25f4-72a6-4fa9-a028-b3b6de8a3568_p2" x="3914.6104" y="7193.6836"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6805dcaf-891a-4fb5-9774-4051c5a7eedc"> <bbox w="10.0" h="10.0" x="4866.4565" y="4945.75"/> <port id="pr_6805dcaf-891a-4fb5-9774-4051c5a7eedc_p1" x="4871.4565" y="4965.75"/> <port id="pr_6805dcaf-891a-4fb5-9774-4051c5a7eedc_p2" x="4871.4565" y="4935.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_88ceec0b-eb2a-449f-857d-a2e4d74a4271"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8242752 by TP53 PMID:12676992 in MEF by CTBP1 and CTBP2 (RT-PCR, double knocked out) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3951.117" y="7208.371"/> <port id="pr_88ceec0b-eb2a-449f-857d-a2e4d74a4271_p1" x="3956.117" y="7228.371"/> <port id="pr_88ceec0b-eb2a-449f-857d-a2e4d74a4271_p2" x="3956.117" y="7198.371"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a64996c8-0885-4f5e-b38e-eaf5ecdc4f3b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16728594 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3992.0615" y="7204.1826"/> <port id="pr_a64996c8-0885-4f5e-b38e-eaf5ecdc4f3b_p1" x="3997.0615" y="7224.1826"/> <port id="pr_a64996c8-0885-4f5e-b38e-eaf5ecdc4f3b_p2" x="3997.0615" y="7194.1826"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9d35e1d3-5366-423e-8835-e470117a84c7"> <bbox w="10.0" h="10.0" x="3160.708" y="6012.5117"/> <port id="pr_9d35e1d3-5366-423e-8835-e470117a84c7_p1" x="3165.708" y="6032.5117"/> <port id="pr_9d35e1d3-5366-423e-8835-e470117a84c7_p2" x="3165.708" y="6002.5117"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dfb30bfa-a1a7-47d0-8600-bf06ceb093da"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11389439 PMID:11591730 by p53 PMID:11559530 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4070.5132" y="7201.299"/> <port id="pr_dfb30bfa-a1a7-47d0-8600-bf06ceb093da_p1" x="4075.5132" y="7221.299"/> <port id="pr_dfb30bfa-a1a7-47d0-8600-bf06ceb093da_p2" x="4075.5132" y="7191.299"/> </glyph> <glyph class="process" orientation="vertical" id="pr_52256e42-1761-46f3-90aa-8e05e73b4fb3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16839880 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4106.1797" y="7219.1826"/> <port id="pr_52256e42-1761-46f3-90aa-8e05e73b4fb3_p1" x="4111.1797" y="7239.1826"/> <port id="pr_52256e42-1761-46f3-90aa-8e05e73b4fb3_p2" x="4111.1797" y="7209.1826"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1392a6c6-c24c-4ea2-a523-0059f65d5de8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17554199 by p53 PMID:17656095 PMID:17540599 PMID:17554337 PMID:19696787 in TIG3 TERT/ΔB-RAF:ER, by ELK1 (siRNA ELK1 and MIR34A PCR; ChIP) in HEK293 by ELK1, gene reporter References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3279.4248" y="7038.7725"/> <port id="pr_1392a6c6-c24c-4ea2-a523-0059f65d5de8_p1" x="3299.4248" y="7043.7725"/> <port id="pr_1392a6c6-c24c-4ea2-a523-0059f65d5de8_p2" x="3269.4248" y="7043.7725"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ec0616b8-5c08-4c81-ac0c-8b2ba74a4240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14985507 mouse homolog siah-1b is a direct target of p53 PMID:12077306 sequence analysis predicts SIAH1 as a p53 target gene PMID:12438652 in human colorectal carcinoma-derived cell lines with a somatic knock-out of p53 (p53 +/+, p53 +/−, and p53 −/−), SIAH1 expression correlates with that of p53 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4186.846" y="7220.473"/> <port id="pr_ec0616b8-5c08-4c81-ac0c-8b2ba74a4240_p1" x="4191.846" y="7240.473"/> <port id="pr_ec0616b8-5c08-4c81-ac0c-8b2ba74a4240_p2" x="4191.846" y="7210.473"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e5182065-2baf-4128-9530-5ef5d88a3023"> <bbox w="10.0" h="10.0" x="3296.8164" y="6614.61"/> <port id="pr_e5182065-2baf-4128-9530-5ef5d88a3023_p1" x="3316.8164" y="6619.61"/> <port id="pr_e5182065-2baf-4128-9530-5ef5d88a3023_p2" x="3286.8164" y="6619.61"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4ca134cb-e51c-4cf7-8823-40d21f08f472"> <bbox w="10.0" h="10.0" x="5345.3696" y="6468.9277"/> <port id="pr_4ca134cb-e51c-4cf7-8823-40d21f08f472_p1" x="5335.3696" y="6473.9277"/> <port id="pr_4ca134cb-e51c-4cf7-8823-40d21f08f472_p2" x="5365.3696" y="6473.9277"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3af1034b-508b-4200-98d2-0db6a2cacd05"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18328430 MIR17HG transactivation by E2F1 PMID:15944709 MIR17-92 cluster transactivation by MYC PMID:19696742 MIR17HG transactivation repressed by TP53. Proposed mechanism: TP53- and TBP- binding sites overlaps. in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization. in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53 in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4263.71" y="7189.5"/> <port id="pr_3af1034b-508b-4200-98d2-0db6a2cacd05_p1" x="4268.71" y="7209.5"/> <port id="pr_3af1034b-508b-4200-98d2-0db6a2cacd05_p2" x="4268.71" y="7179.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e15eb37f-ae18-4eeb-93e9-5847d2e5f781"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15136036 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3937.983" y="6864.424"/> <port id="pr_e15eb37f-ae18-4eeb-93e9-5847d2e5f781_p1" x="3957.983" y="6869.424"/> <port id="pr_e15eb37f-ae18-4eeb-93e9-5847d2e5f781_p2" x="3927.983" y="6869.424"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8236e90a-c6ae-497e-867f-54056cab785e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15944709 MIR20A and MIR17 repress E2F1. MYC, through MIR17 and MIR20A, inactivates E2F1 at the post-transcriptional level. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5648.468" y="6551.331"/> <port id="pr_8236e90a-c6ae-497e-867f-54056cab785e_p1" x="5638.468" y="6556.331"/> <port id="pr_8236e90a-c6ae-497e-867f-54056cab785e_p2" x="5668.468" y="6556.331"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_911924e7-f860-4638-b7dd-8368b894fb3d"> <bbox w="20.0" h="20.0" x="3097.4285" y="6811.555"/> <port id="logicglyph_911924e7-f860-4638-b7dd-8368b894fb3d_p1" x="3087.4285" y="6821.555"/> <port id="logicglyph_911924e7-f860-4638-b7dd-8368b894fb3d_p2" x="3127.4285" y="6821.555"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5e67aa2d-4cf5-4068-973b-84abeb9c732e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18328430 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4380.88" y="7019.549"/> <port id="pr_5e67aa2d-4cf5-4068-973b-84abeb9c732e_p1" x="4400.88" y="7024.549"/> <port id="pr_5e67aa2d-4cf5-4068-973b-84abeb9c732e_p2" x="4370.88" y="7024.549"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9a0848b7-6edf-4340-abb2-d6f088fa007e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18328430 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4506.557" y="7234.848"/> <port id="pr_9a0848b7-6edf-4340-abb2-d6f088fa007e_p1" x="4511.557" y="7254.848"/> <port id="pr_9a0848b7-6edf-4340-abb2-d6f088fa007e_p2" x="4511.557" y="7224.848"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5c54e830-9522-4a9c-b9da-c582bdbea05e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11050388 FOXO3 PMID:19494111 FOXO3, in Hep3B human hepatocarcinoma cell line PMID:17604722 CHOP CEBPA PMID:11495903 JNK PMID:11301023 JNK, in neurons in SH-EP, in NB15 neuroblastoma cell lines expressing a FOXO3-ER fusion, upon 4OHT. BIM knock down protects from apoptosis PMID:18281283 in mouse lymphocytes with targeted expression of p52 PMID:14684737 in NIH3T3, the 3 major isoforms are upregulated by E2F1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4708.3125" y="7233.674"/> <port id="pr_5c54e830-9522-4a9c-b9da-c582bdbea05e_p1" x="4713.3125" y="7253.674"/> <port id="pr_5c54e830-9522-4a9c-b9da-c582bdbea05e_p2" x="4713.3125" y="7223.674"/> </glyph> <glyph class="process" orientation="vertical" id="pr_48f2d72c-3401-4610-b2f2-1e5d60c24930"> <bbox w="10.0" h="10.0" x="4689.457" y="6997.25"/> <port id="pr_48f2d72c-3401-4610-b2f2-1e5d60c24930_p1" x="4694.457" y="7017.25"/> <port id="pr_48f2d72c-3401-4610-b2f2-1e5d60c24930_p2" x="4694.457" y="6987.25"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_7b229480-cd60-43a1-a967-8238137b24bd"> <bbox w="20.0" h="20.0" x="4019.0168" y="6782.3315"/> <port id="logicglyph_7b229480-cd60-43a1-a967-8238137b24bd_p1" x="4009.0168" y="6792.3315"/> 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<head> <title/> </head> <body>References_begin: PMID:18490439 ENO1 gene products interact with NOTCH1 intracellular domain, thus competing with YY1, to repress MYC expression PMID:19219071 MYC regulation by FUBP1 PMID:2191300 in WEHI 231 murine B-lymphoma cells, by NFkappaB References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5056.52" y="7198.75"/> <port id="pr_bc8241c0-b287-4fb2-86cb-8906c6c47a7d_p1" x="5061.52" y="7218.75"/> <port id="pr_bc8241c0-b287-4fb2-86cb-8906c6c47a7d_p2" x="5061.52" y="7188.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3ac2072c-ccba-4312-ae3e-53e2701aa69e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17942906 in Burkitt lymphoma cells PMID:9804616 in human rhabdomyosarcoma Rh30 but not Rh1 cells, rapamycin inhibits serum-induced expression of MYC 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PMID:11557773 by HIF1 PMID:14672622 in liver tumors by HIF1 PMID:16782875 by MLX:MLXIP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5123.598" y="7229.911"/> <port id="pr_ee09faf4-036d-43c9-ab39-0605c45b442e_p1" x="5128.598" y="7249.911"/> <port id="pr_ee09faf4-036d-43c9-ab39-0605c45b442e_p2" x="5128.598" y="7219.911"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_49093c3b-370d-48a1-8791-9b1d9555c02a"> <bbox w="10.0" h="10.0" x="3960.4824" y="6936.2656"/> <port id="pr_49093c3b-370d-48a1-8791-9b1d9555c02a_p1" x="3980.4824" y="6941.2656"/> <port id="pr_49093c3b-370d-48a1-8791-9b1d9555c02a_p2" x="3950.4824" y="6941.2656"/> </glyph> <glyph class="process" orientation="vertical" id="pr_27396e49-688f-4416-ba1c-0dd155c0b646"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11744734 in renal carcinoma 786-0 cells (VHL deficient), in HIF1 KO MEFs PMID:17143338 in pancreatic and gastric cancer cell lines (correlation HIF stabilisation and gene expression) PMID:16782875 by MLX:MLXIP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5135.0566" y="7199.75"/> <port id="pr_27396e49-688f-4416-ba1c-0dd155c0b646_p1" x="5140.0566" y="7219.75"/> <port id="pr_27396e49-688f-4416-ba1c-0dd155c0b646_p2" x="5140.0566" y="7189.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_95c8ebd6-c6ce-412b-9847-9d029c69b4e8"> <bbox w="10.0" h="10.0" x="3836.4607" y="6606.9707"/> <port id="pr_95c8ebd6-c6ce-412b-9847-9d029c69b4e8_p1" x="3856.4607" y="6611.9707"/> <port id="pr_95c8ebd6-c6ce-412b-9847-9d029c69b4e8_p2" x="3826.4607" y="6611.9707"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9aafb737-aad6-4180-8fa1-a8428d4d442b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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<head> <title/> </head> <body>References_begin: PMID:17418790 in Hela cells, in RCC4 renal carcinoma human cells, in mouse References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5212.3125" y="7197.25"/> <port id="pr_3f9e09a3-2abd-4be9-8854-9f1700657484_p1" x="5217.3125" y="7217.25"/> <port id="pr_3f9e09a3-2abd-4be9-8854-9f1700657484_p2" x="5217.3125" y="7187.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cc9c6735-c7d7-4985-a49a-de97888ed315"> <bbox w="10.0" h="10.0" x="3411.5" y="6613.955"/> <port id="pr_cc9c6735-c7d7-4985-a49a-de97888ed315_p1" x="3431.5" y="6618.955"/> <port id="pr_cc9c6735-c7d7-4985-a49a-de97888ed315_p2" x="3401.5" y="6618.955"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ba550a9e-968b-4a83-9956-e752d24941d3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17418790 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5277.005" y="7233.75"/> <port id="pr_ba550a9e-968b-4a83-9956-e752d24941d3_p1" x="5282.005" y="7253.75"/> <port id="pr_ba550a9e-968b-4a83-9956-e752d24941d3_p2" x="5282.005" y="7223.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5a089421-0ebb-42cd-9fda-c14b4ddb0681"> <bbox w="10.0" h="10.0" x="3658.375" y="5830.158"/> <port id="pr_5a089421-0ebb-42cd-9fda-c14b4ddb0681_p1" x="3678.375" y="5835.158"/> <port id="pr_5a089421-0ebb-42cd-9fda-c14b4ddb0681_p2" x="3648.375" y="5835.158"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5f9fcc9e-1591-436c-9e98-3766c7de0577"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17143338 in pancreatic and gastric cancer cell lines (correlation HIF stabilisation and gene expression) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5285.2676" y="7199.25"/> <port id="pr_5f9fcc9e-1591-436c-9e98-3766c7de0577_p1" x="5290.2676" y="7219.25"/> <port id="pr_5f9fcc9e-1591-436c-9e98-3766c7de0577_p2" x="5290.2676" y="7189.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a132e557-3e65-462f-8f59-2c0e689c9c0d"> <bbox w="10.0" h="10.0" x="5269.148" y="6994.25"/> <port id="pr_a132e557-3e65-462f-8f59-2c0e689c9c0d_p1" x="5274.148" y="7014.25"/> <port id="pr_a132e557-3e65-462f-8f59-2c0e689c9c0d_p2" x="5274.148" y="6984.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d536014e-b21d-44f4-b965-ee4858f1405d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8955077 in HepG3 PMID:8089148 in Hela and HepG3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5356.2188" y="7235.25"/> <port id="pr_d536014e-b21d-44f4-b965-ee4858f1405d_p1" x="5361.2188" y="7255.25"/> <port id="pr_d536014e-b21d-44f4-b965-ee4858f1405d_p2" x="5361.2188" y="7225.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d3e34281-173e-4695-89fa-755420964ca0"> <bbox w="10.0" h="10.0" x="5347.1367" y="7013.25"/> <port id="pr_d3e34281-173e-4695-89fa-755420964ca0_p1" x="5352.1367" y="7033.25"/> <port id="pr_d3e34281-173e-4695-89fa-755420964ca0_p2" x="5352.1367" y="7003.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_43d558b0-2fda-4b5d-b59c-f2fce0780e0b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16126909 in human breast carcinoma BT-549 cells, by HIF1 PMID:10823814 in rat1a rat fibroblasts upon c-myc overexpression References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5364.742" y="7200.75"/> <port id="pr_43d558b0-2fda-4b5d-b59c-f2fce0780e0b_p1" x="5369.742" y="7220.75"/> <port id="pr_43d558b0-2fda-4b5d-b59c-f2fce0780e0b_p2" x="5369.742" y="7190.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_548a7406-e23d-433b-85e0-7bb786ffe5ee"> <bbox w="10.0" h="10.0" x="3278.0781" y="3905.75"/> <port id="pr_548a7406-e23d-433b-85e0-7bb786ffe5ee_p1" x="3283.0781" y="3925.75"/> <port id="pr_548a7406-e23d-433b-85e0-7bb786ffe5ee_p2" x="3283.0781" y="3895.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_183a5c37-971d-459c-90a6-74f785aa5c8c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:7493931 in HepG2 by HIF1 (EMSA, reporter plasmids) PMID:9525945 in chinese hamster ovary cells by HIF1 PMID:15059920 in Saos2, in human embryonal rhabdomyosarcoma derived RD (ATCC no. CCL-136), in murine skeletal muscle-derived C2C12 myoblasts (ATCC no. CRL-1772), by TP53 (luciferase reporter) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5437.3506" y="7231.25"/> <port id="pr_183a5c37-971d-459c-90a6-74f785aa5c8c_p1" x="5442.3506" y="7251.25"/> <port id="pr_183a5c37-971d-459c-90a6-74f785aa5c8c_p2" x="5442.3506" y="7221.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d8e6bde3-6efc-4210-9bfd-b76ce2784af7"> <bbox w="10.0" h="10.0" x="3153.517" y="3719.25"/> <port id="pr_d8e6bde3-6efc-4210-9bfd-b76ce2784af7_p1" x="3158.517" y="3739.25"/> <port id="pr_d8e6bde3-6efc-4210-9bfd-b76ce2784af7_p2" x="3158.517" y="3709.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b1b6370f-2160-4104-b0ee-4d962acdefd6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15379897 in CCF-STTG1 human glial cells (EMSA + supershift with HRE derived from the PKM2 promoter) PMID:8089148 in Hela and HepG3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5439.991" y="7200.75"/> <port id="pr_b1b6370f-2160-4104-b0ee-4d962acdefd6_p1" x="5444.991" y="7220.75"/> <port id="pr_b1b6370f-2160-4104-b0ee-4d962acdefd6_p2" x="5444.991" y="7190.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5df03f51-bb82-4f20-a8fc-b6b45aad2565"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18464261 in human squamous cell carcinoma from the tongue References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5435.0938" y="6998.25"/> <port id="pr_5df03f51-bb82-4f20-a8fc-b6b45aad2565_p1" x="5440.0938" y="7018.25"/> <port id="pr_5df03f51-bb82-4f20-a8fc-b6b45aad2565_p2" x="5440.0938" y="6988.25"/> </glyph> <glyph class="or" 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PMID:7500013 in murine macrophage derived from C57BL/6 mice and transformed with J2 (v-raf1v-myc) recombinant retrovirus, by HIF1 PMID:9486205 in rat lung epithelia, by hypoxia in bovine pulmonary artery endothelial cells, HIF1 regulates the murine iNOS promoter (supershifted EMSA + gene reporter) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5672.922" y="7198.75"/> <port id="pr_8ee4c5fa-e6c9-4155-8242-897ac68ace7c_p1" x="5677.922" y="7218.75"/> <port id="pr_8ee4c5fa-e6c9-4155-8242-897ac68ace7c_p2" x="5677.922" y="7188.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_191d7314-2ab1-45c3-aa3b-2e3b86d85017"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19211554 in PC-3 human prostate cancer cell line by HIF, transactivation of the promoter (ChIP, EMSA, reporter gene assay) PMID:10435632 in murine immortalized bone marrow-derived pro-B-cell BA/F3, by STAT5 upon IL3 PMID:10428780 AND PMID:10428030 in murine erythroleukemia HCD-57 cells, by STAT5 upon EPO (HGNC:3415) treatment PMID:11756417 in UT-7/TPO human TPO-dependent megakaryocytic cell line, by STAT5 and NF-kappaB, upon TPO References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5741.9897" y="7225.333"/> <port id="pr_191d7314-2ab1-45c3-aa3b-2e3b86d85017_p1" x="5746.9897" y="7245.333"/> <port id="pr_191d7314-2ab1-45c3-aa3b-2e3b86d85017_p2" x="5746.9897" y="7215.333"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_39fb12b0-9e23-4d71-985b-262710b77eac"> <bbox w="10.0" h="10.0" x="5850.914" y="7010.75"/> <port id="pr_39fb12b0-9e23-4d71-985b-262710b77eac_p1" x="5840.914" y="7015.75"/> <port id="pr_39fb12b0-9e23-4d71-985b-262710b77eac_p2" x="5870.914" y="7015.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b985a02b-9106-4468-8c06-c11913c1ad87"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18158893 in MEFs, in MCF7 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5745.9473" y="7197.5"/> <port id="pr_b985a02b-9106-4468-8c06-c11913c1ad87_p1" x="5750.9473" y="7217.5"/> <port id="pr_b985a02b-9106-4468-8c06-c11913c1ad87_p2" x="5750.9473" y="7187.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_64f47331-4005-4abf-850f-81e6d2b63c6b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19188590 in melanomas, correlation between MIR182 expression and progression from primary to metastatic melanoma, anticorrelation with FOXO3 level. FOXO3 over-expression inhibits MIR182 metastatic effect FOXO3 is a direct target of MIR182 BIM downregulated by MIR182 supposedly through FOXO3 inhibition References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5902.755" y="6993.75"/> <port id="pr_64f47331-4005-4abf-850f-81e6d2b63c6b_p1" x="5892.755" y="6998.75"/> <port id="pr_64f47331-4005-4abf-850f-81e6d2b63c6b_p2" x="5922.755" y="6998.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_62a828b8-2cfe-4d95-8504-2a6b83d4acd3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15545625 PMID:11884613 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5820.106" y="7227.75"/> <port id="pr_62a828b8-2cfe-4d95-8504-2a6b83d4acd3_p1" x="5825.106" y="7247.75"/> <port id="pr_62a828b8-2cfe-4d95-8504-2a6b83d4acd3_p2" x="5825.106" 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20028863 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5980.654" y="7231.3994"/> <port id="pr_65f495b7-6a1e-4167-a009-03e3283a1e3e_p1" x="5985.654" y="7251.3994"/> <port id="pr_65f495b7-6a1e-4167-a009-03e3283a1e3e_p2" x="5985.654" y="7221.3994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6b582c0d-09bc-43d5-8fd4-9cb46221037f"> <bbox w="10.0" h="10.0" x="6573.507" y="6533.75"/> <port id="pr_6b582c0d-09bc-43d5-8fd4-9cb46221037f_p1" x="6563.507" y="6538.75"/> <port id="pr_6b582c0d-09bc-43d5-8fd4-9cb46221037f_p2" x="6593.507" y="6538.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8efbb28e-f1e4-4eba-b711-2c3ccadba59a"> <bbox w="10.0" h="10.0" x="6613.3345" y="6590.75"/> <port id="pr_8efbb28e-f1e4-4eba-b711-2c3ccadba59a_p1" x="6603.3345" y="6595.75"/> <port id="pr_8efbb28e-f1e4-4eba-b711-2c3ccadba59a_p2" x="6633.3345" y="6595.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cde0e78e-72b8-4125-8427-c5063377e6cd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:1829648 in human monocytes PMID:8096091 in Jurkat References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6054.244" y="7226.8994"/> <port id="pr_cde0e78e-72b8-4125-8427-c5063377e6cd_p1" x="6059.244" y="7246.8994"/> <port id="pr_cde0e78e-72b8-4125-8427-c5063377e6cd_p2" x="6059.244" y="7216.8994"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5383b5a7-a4f0-4fdc-b72c-bd5bd7a1ed1d"> <bbox w="10.0" h="10.0" x="5809.7324" y="4186.25"/> <port id="pr_5383b5a7-a4f0-4fdc-b72c-bd5bd7a1ed1d_p1" x="5814.7324" y="4206.25"/> <port 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x="6141.2544" y="6984.125"/> </glyph> <glyph class="process" orientation="vertical" id="pr_952a7b18-86b6-4f00-aaf3-add63970b049"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17438126 in murine C2C12 myoblast cells, in murine 10T1/2 fibroblast cells, in human 293T cells References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6129.377" y="7228.3994"/> <port id="pr_952a7b18-86b6-4f00-aaf3-add63970b049_p1" x="6134.377" y="7248.3994"/> <port id="pr_952a7b18-86b6-4f00-aaf3-add63970b049_p2" x="6134.377" y="7218.3994"/> </glyph> <glyph class="process" orientation="vertical" id="pr_432f55a8-e6c0-4003-a873-3f930a9b43d8"> <bbox w="10.0" h="10.0" x="6211.211" y="7009.25"/> <port id="pr_432f55a8-e6c0-4003-a873-3f930a9b43d8_p1" x="6216.211" y="7029.25"/> <port id="pr_432f55a8-e6c0-4003-a873-3f930a9b43d8_p2" x="6216.211" y="6999.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f31f6e2d-c5e7-462a-a0cc-ef6e46a3b445"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8051093 in Hela cells References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6134.1475" y="7199.3994"/> <port id="pr_f31f6e2d-c5e7-462a-a0cc-ef6e46a3b445_p1" x="6139.1475" y="7219.3994"/> <port id="pr_f31f6e2d-c5e7-462a-a0cc-ef6e46a3b445_p2" x="6139.1475" y="7189.3994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_66177046-4c7d-44e6-9777-dc84394c7869"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19293287 in SH-SY5Y human neuroblastoma cell line in Swiss-3T3 mouse fibroblast cell line in primary human lung fibroblasts in H1299 human non-small cell lung carcinoma cell line (p53 null) with ectopic expression of p53, identification of the miRNA site in the UTR References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6269.25" y="6993.75"/> <port id="pr_66177046-4c7d-44e6-9777-dc84394c7869_p1" x="6259.25" y="6998.75"/> <port id="pr_66177046-4c7d-44e6-9777-dc84394c7869_p2" x="6289.25" y="6998.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2658f68c-adcd-4240-a7ae-93bff94cd735"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15102937 in Hela References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6201.6636" y="7227.75"/> <port id="pr_2658f68c-adcd-4240-a7ae-93bff94cd735_p1" x="6206.6636" y="7247.75"/> <port 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id="pr_2ba2e9f9-430f-4e0c-9d3f-e8dca875b61b_p1" x="6484.4424" y="6998.75"/> <port id="pr_2ba2e9f9-430f-4e0c-9d3f-e8dca875b61b_p2" x="6514.4424" y="6998.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5cd44132-fbf0-4339-882d-90adf5d3b129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17724475 in Hela References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6452.841" y="7225.378"/> <port id="pr_5cd44132-fbf0-4339-882d-90adf5d3b129_p1" x="6457.841" y="7245.378"/> <port id="pr_5cd44132-fbf0-4339-882d-90adf5d3b129_p2" x="6457.841" y="7215.378"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f3b59b94-b368-4a62-bff7-77605136d42d"> <bbox w="10.0" h="10.0" x="7101.9316" y="6203.75"/> <port id="pr_f3b59b94-b368-4a62-bff7-77605136d42d_p1" x="7106.9316" y="6223.75"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16915281 PMID:22841746 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7107.1045" y="6653.375"/> <port id="pr_9b78b144-52e3-4ad4-96f1-85bd6a610f6d_p1" x="7097.1045" y="6658.375"/> <port id="pr_9b78b144-52e3-4ad4-96f1-85bd6a610f6d_p2" x="7127.1045" y="6658.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a838e637-aa1d-45a4-9d64-c2cbdf1902f4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:1332946 in BL41 human Burkit's lymphoma B cells upon infection with EBV References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6528.758" y="7224.3994"/> <port id="pr_a838e637-aa1d-45a4-9d64-c2cbdf1902f4_p1" x="6533.758" y="7244.3994"/> <port 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<body>References_begin: PMID:15774466 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7010.911" y="7200.8994"/> <port id="pr_700e7c48-e4b0-4542-b765-28e53f46cb91_p1" x="7015.911" y="7220.8994"/> <port id="pr_700e7c48-e4b0-4542-b765-28e53f46cb91_p2" x="7015.911" y="7190.8994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0366195c-1d08-4b33-aebd-5c451267a96e"> <bbox w="10.0" h="10.0" x="3853.375" y="5983.8594"/> <port id="pr_0366195c-1d08-4b33-aebd-5c451267a96e_p1" x="3873.375" y="5988.8594"/> <port id="pr_0366195c-1d08-4b33-aebd-5c451267a96e_p2" x="3843.375" y="5988.8594"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_15dd77b1-43d7-403b-a6f5-8b4977581a3d"> <bbox w="10.0" h="10.0" x="1636.0" y="1104.6896"/> <port id="pr_15dd77b1-43d7-403b-a6f5-8b4977581a3d_p1" x="1656.0" y="1109.6896"/> <port id="pr_15dd77b1-43d7-403b-a6f5-8b4977581a3d_p2" x="1626.0" y="1109.6896"/> </glyph> <glyph class="process" orientation="vertical" id="pr_835ec9ae-ad30-4f14-9fd4-2d5c3fa16d26"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10531306 allosterinc inhibition of HK1 by glucose 6P PMID:11078441 HK inhibition by long-chain acyl-CoAs PMID:10760476 PMID:7130182 GCK inhibition by long-chain acyl-CoAs PMID:12931191 in mouse liver mitochondria GCK activation by phosphorylated BAD within a mitochondrial protein complex References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="705.0" y="746.25"/> <port id="pr_835ec9ae-ad30-4f14-9fd4-2d5c3fa16d26_p1" x="710.0" y="736.25"/> <port id="pr_835ec9ae-ad30-4f14-9fd4-2d5c3fa16d26_p2" x="710.0" y="766.25"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_19172be8-1928-4b83-a865-ae5d6a10c014"> <bbox w="20.0" h="20.0" x="756.50415" y="730.43494"/> <port 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1503.0" y="1078.6896"/> <port id="pr_a9b933f1-ddcf-4013-86e5-a9b06a9eda85_p1" x="1508.0" y="1068.6896"/> <port id="pr_a9b933f1-ddcf-4013-86e5-a9b06a9eda85_p2" x="1508.0" y="1098.6896"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8ebccfb5-82fd-47e3-9357-6dd78f907c00"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PFK is a tetramer of the 1 to 3 of the different isoforms. Its exact composition depends on the cell type. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1502.0" y="1127.9396"/> <port id="pr_8ebccfb5-82fd-47e3-9357-6dd78f907c00_p1" x="1507.0" y="1147.9396"/> <port id="pr_8ebccfb5-82fd-47e3-9357-6dd78f907c00_p2" x="1507.0" y="1117.9396"/> </glyph> <glyph class="process" orientation="vertical" id="pr_23ebf300-7087-42e1-b9cf-8cbb9d74ffee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Dihydroxyacetone phosphate lies in the glycolysis metabolic pathway, and is one of the two products of breakdown of fructose 1,6-bisphosphate, along with glyceraldehyde 3-phosphate. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1135.0" y="1239.6875"/> <port id="pr_23ebf300-7087-42e1-b9cf-8cbb9d74ffee_p1" x="1140.0" y="1229.6875"/> <port id="pr_23ebf300-7087-42e1-b9cf-8cbb9d74ffee_p2" x="1140.0" y="1259.6875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f5838a89-9961-4604-99bf-89da0e8faca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8061610 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1210.0" y="1285.0"/> <port id="pr_f5838a89-9961-4604-99bf-89da0e8faca2_p1" x="1230.0" y="1290.0"/> <port id="pr_f5838a89-9961-4604-99bf-89da0e8faca2_p2" x="1200.0" y="1290.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ff6d8687-5fc5-4dbc-b2bf-2b013e998c80"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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PMID:10653665 fructose 6-phosphate was found to be a potent activator (60-fold) of the unphosphorylated recombinant enzyme References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="734.24347" y="2738.625"/> <port id="pr_9d36cff3-288e-44a9-bbc8-060570866f74_p1" x="739.24347" y="2728.625"/> <port id="pr_9d36cff3-288e-44a9-bbc8-060570866f74_p2" x="739.24347" y="2758.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5e0f8e1d-98c7-4206-aad3-b739708b5439"> <bbox w="10.0" h="10.0" x="1331.7163" y="2010.8988"/> <port id="pr_5e0f8e1d-98c7-4206-aad3-b739708b5439_p1" x="1351.7163" y="2015.8988"/> <port id="pr_5e0f8e1d-98c7-4206-aad3-b739708b5439_p2" x="1321.7163" y="2015.8988"/> </glyph> <glyph class="process" orientation="vertical" id="pr_98015d41-8e26-4c6c-9c9c-a382841b6563"> <bbox w="10.0" h="10.0" x="1135.0" y="1481.875"/> <port id="pr_98015d41-8e26-4c6c-9c9c-a382841b6563_p1" x="1140.0" y="1471.875"/> <port id="pr_98015d41-8e26-4c6c-9c9c-a382841b6563_p2" x="1140.0" y="1501.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_47435ed6-2c78-4fe6-8e57-7bdbce062cfd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18408758 in human epithelial ovarian cancer cells References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6214.16" y="4170.75"/> <port id="pr_47435ed6-2c78-4fe6-8e57-7bdbce062cfd_p1" x="6219.16" y="4190.75"/> <port id="pr_47435ed6-2c78-4fe6-8e57-7bdbce062cfd_p2" x="6219.16" y="4160.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d0026750-53b2-4a4e-9a1b-2b972269e02f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17435549 References_end 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lung, by NFE2L2 proposed also in human, and deregulation in patients with chronic obstructive pulmonary disorder References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6690.676" y="7200.91"/> <port id="pr_58620e47-6619-4cb4-ba60-9bb458b6c7ee_p1" x="6695.676" y="7220.91"/> <port id="pr_58620e47-6619-4cb4-ba60-9bb458b6c7ee_p2" x="6695.676" y="7190.91"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d4ee5da4-b95a-40f0-a278-daff7b9346fc"> <bbox w="10.0" h="10.0" x="9157.2705" y="4228.75"/> <port id="pr_d4ee5da4-b95a-40f0-a278-daff7b9346fc_p1" x="9162.2705" y="4248.75"/> <port id="pr_d4ee5da4-b95a-40f0-a278-daff7b9346fc_p2" x="9162.2705" y="4218.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_73a4182d-acb7-438b-afda-05f7d99a0b8c"> <bbox w="10.0" h="10.0" x="5611.414" y="5338.75"/> <port id="pr_73a4182d-acb7-438b-afda-05f7d99a0b8c_p1" x="5616.414" y="5358.75"/> <port id="pr_73a4182d-acb7-438b-afda-05f7d99a0b8c_p2" x="5616.414" y="5328.75"/> 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Its expression is confirmed and shown to be abrogated following infection with an Ad-virus encoding an NF-kB super-repressor (RT-PCR). References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6761.337" y="7235.91"/> <port id="pr_a0c6fc0a-f6f0-4f2b-b857-27c02078de71_p1" x="6766.337" y="7255.91"/> <port id="pr_a0c6fc0a-f6f0-4f2b-b857-27c02078de71_p2" x="6766.337" y="7225.91"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5d5cee08-bdc3-4b4e-83ad-83c232a9e136"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19494111 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5207.5" y="7805.5"/> <port id="pr_5d5cee08-bdc3-4b4e-83ad-83c232a9e136_p1" x="5212.5" y="7825.5"/> <port id="pr_5d5cee08-bdc3-4b4e-83ad-83c232a9e136_p2" x="5212.5" y="7795.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_72b34b3c-98f2-4240-80da-33c00c94ac1f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5086.625" y="7640.0"/> <port id="pr_72b34b3c-98f2-4240-80da-33c00c94ac1f_p1" x="5091.625" y="7660.0"/> <port id="pr_72b34b3c-98f2-4240-80da-33c00c94ac1f_p2" x="5091.625" y="7630.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7afc9b3c-6c2e-4956-b762-efaac28ba95f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10102273 in 293T, EMSA in CCL23 chinese hamster lung fibroblast cell line, gene reporter in cerebellar granule neurones and CCL23 cells, non phosphorylatable FOXO induces apoptosis that is blocked by a Fas decoy receptor in Jurkat, non phosphorylatable FOXO induces apoptosis that is blocked by FAS or FADD mutations References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4600.2646" y="7238.3633"/> <port id="pr_7afc9b3c-6c2e-4956-b762-efaac28ba95f_p1" x="4605.2646" y="7258.3633"/> <port id="pr_7afc9b3c-6c2e-4956-b762-efaac28ba95f_p2" x="4605.2646" y="7228.3633"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8767fa57-3c9b-4f4e-a883-08780cbf60f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7233.2573" y="4371.9316"/> <port id="pr_8767fa57-3c9b-4f4e-a883-08780cbf60f6_p1" x="7238.2573" y="4391.9316"/> <port id="pr_8767fa57-3c9b-4f4e-a883-08780cbf60f6_p2" x="7238.2573" y="4361.9316"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_00a6315b-a79f-491b-867c-188702f1b583"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9065430 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7935.75" y="1863.5"/> <port id="pr_00a6315b-a79f-491b-867c-188702f1b583_p1" x="7955.75" y="1868.5"/> <port id="pr_00a6315b-a79f-491b-867c-188702f1b583_p2" x="7925.75" y="1868.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e3ed7cfc-04ff-4ab5-8f93-12fb19fc1ccf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9065430 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7929.75" y="1935.5"/> <port id="pr_e3ed7cfc-04ff-4ab5-8f93-12fb19fc1ccf_p1" 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Phosphomutant of FOXO3 is not phosphorylated and the expression of a reporter gene is not inhibited. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8452.803" y="1788.4316"/> <port id="pr_e14ceb8f-c391-466b-a9f4-d00d9b4ea0b0_p1" x="8472.803" y="1793.4316"/> <port id="pr_e14ceb8f-c391-466b-a9f4-d00d9b4ea0b0_p2" x="8442.803" y="1793.4316"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0838ea51-d5e3-4a0f-b2de-43bfed64bf67"> <bbox w="10.0" h="10.0" x="8452.803" y="1808.4316"/> <port id="pr_0838ea51-d5e3-4a0f-b2de-43bfed64bf67_p1" x="8442.803" y="1813.4316"/> <port id="pr_0838ea51-d5e3-4a0f-b2de-43bfed64bf67_p2" x="8472.803" y="1813.4316"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ea37cc03-bcb5-4c99-afb6-0404d72908fb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: logical:re333_s2093=FALSE References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8400.47" y="1864.5"/> <port id="pr_ea37cc03-bcb5-4c99-afb6-0404d72908fb_p1" x="8405.47" y="1884.5"/> <port id="pr_ea37cc03-bcb5-4c99-afb6-0404d72908fb_p2" x="8405.47" y="1854.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d902cfc9-1c29-47ae-b60e-104b2aa33b3d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15509864 review PMID:16054095 by CAMKK2 PMID:16054096 PMID:17244528 by calcium via CAMKK2 and AMPK PMID:15980064 by CAMKK PMID:18692468 propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity. PMID:19197243 in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure in MCF10A upon Ca2+ by CAMKK2 High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation PMID:19037093PMID:17244528 PMID:20484410 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8298.5" y="2456.5"/> <port id="pr_d902cfc9-1c29-47ae-b60e-104b2aa33b3d_p1" x="8288.5" y="2461.5"/> <port id="pr_d902cfc9-1c29-47ae-b60e-104b2aa33b3d_p2" x="8318.5" y="2461.5"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_4286986c-2880-4216-89a7-95153b1639f9"> <bbox w="20.0" h="20.0" x="8296.991" y="2253.6746"/> <port id="logicglyph_4286986c-2880-4216-89a7-95153b1639f9_p1" x="8306.991" y="2243.6746"/> <port id="logicglyph_4286986c-2880-4216-89a7-95153b1639f9_p2" x="8306.991" y="2283.6746"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_ab6d3c5b-836f-4c42-9acc-2fc528acf3ce"> <bbox w="20.0" h="20.0" x="8375.002" y="2375.1052"/> <port id="logicglyph_ab6d3c5b-836f-4c42-9acc-2fc528acf3ce_p1" x="8405.002" y="2385.1052"/> <port id="logicglyph_ab6d3c5b-836f-4c42-9acc-2fc528acf3ce_p2" x="8365.002" y="2385.1052"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b6ed312b-f62f-4cba-94d1-97db731529a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15509864 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8010.0" y="2444.5"/> <port id="pr_b6ed312b-f62f-4cba-94d1-97db731529a4_p1" x="8000.0" y="2449.5"/> <port id="pr_b6ed312b-f62f-4cba-94d1-97db731529a4_p2" x="8030.0" y="2449.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_26034561-5a2e-4e51-b5ba-dae2a280394c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15509864 review PMID:8910387 by LKB1, from rat enzyme LKB1 dependent AMPK phosphorylation induced by glucose starvation PMID:19197243 in MCF10A upon starvation by LKB1 PMID:20160076 in EBV-immortalized B-lymphocytes from healthy individuals, but not from ATM-deficient AT patients, upon H2O2PMID:12546687 In normoxic cells, the very low AMP/ATP ratio (about 0.05) keeps AMPK mainly in the inactive form PMID:19942859 PMID:23030059 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8298.5" y="2484.5"/> <port id="pr_26034561-5a2e-4e51-b5ba-dae2a280394c_p1" x="8288.5" y="2489.5"/> <port id="pr_26034561-5a2e-4e51-b5ba-dae2a280394c_p2" x="8318.5" y="2489.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d6a3db38-a2e2-4067-ab64-ee599796eb6a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12150915 in NIH3T3 in HEK293 PMID:12172553 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8353.75" y="2913.3545"/> <port id="pr_d6a3db38-a2e2-4067-ab64-ee599796eb6a_p1" x="8358.75" y="2903.3545"/> <port id="pr_d6a3db38-a2e2-4067-ab64-ee599796eb6a_p2" x="8358.75" y="2933.3545"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ead17e8a-358f-40c2-9a04-25dec53edacb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14651849 PMID:19339977 review PMID:18692468 SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8526.5" y="2812.8333"/> <port id="pr_ead17e8a-358f-40c2-9a04-25dec53edacb_p1" x="8516.5" y="2817.8333"/> <port id="pr_ead17e8a-358f-40c2-9a04-25dec53edacb_p2" x="8546.5" y="2817.8333"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_e5a12c81-7bbc-4d72-af1a-5c63220637b8"> <bbox w="20.0" h="20.0" x="8522.891" y="2689.2866"/> <port id="logicglyph_e5a12c81-7bbc-4d72-af1a-5c63220637b8_p1" x="8532.891" y="2679.2866"/> <port id="logicglyph_e5a12c81-7bbc-4d72-af1a-5c63220637b8_p2" x="8532.891" y="2719.2866"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6784a350-34c8-4794-847c-1b21740f3fe7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15851026 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8309.25" y="2805.9165"/> <port id="pr_6784a350-34c8-4794-847c-1b21740f3fe7_p1" x="8329.25" y="2810.9165"/> <port id="pr_6784a350-34c8-4794-847c-1b21740f3fe7_p2" x="8299.25" y="2810.9165"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f863fc07-36f6-4675-8949-3e98e2d1b32d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: logical:re354_s2093=FALSE PMID:18198340 DDIT4 mediated hypoxic signalling to mTPMID:12468542 14-3-3_beta_ forms a ternary complex with TSC1 and Akt-phosphorylated TSC2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8295.121" y="3140.4673"/> <port id="pr_f863fc07-36f6-4675-8949-3e98e2d1b32d_p1" x="8315.121" y="3145.4673"/> <port id="pr_f863fc07-36f6-4675-8949-3e98e2d1b32d_p2" x="8285.121" y="3145.4673"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1b3cb756-c049-44f8-b193-216187a7052a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17693255 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8188.75" y="2921.9253"/> <port id="pr_1b3cb756-c049-44f8-b193-216187a7052a_p1" x="8208.75" y="2926.9253"/> <port id="pr_1b3cb756-c049-44f8-b193-216187a7052a_p2" x="8178.75" y="2926.9253"/> </glyph> <glyph class="process" orientation="vertical" id="pr_57cb4c61-fe48-4a64-bb62-4e87a0659cde"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15342917 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8450.104" y="2972.6914"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a inferred from re259 and re260 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8528.24" y="2916.3916"/> <port id="pr_3d1760f6-ecbb-406f-9e95-3788ea3177e8_p1" x="8533.24" y="2906.3916"/> <port id="pr_3d1760f6-ecbb-406f-9e95-3788ea3177e8_p2" x="8533.24" y="2936.3916"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2db54a86-2c7a-4c81-b1d3-ed5e494210a1"> <bbox w="10.0" h="10.0" x="8313.0" y="2818.4387"/> <port id="pr_2db54a86-2c7a-4c81-b1d3-ed5e494210a1_p1" x="8303.0" y="2823.4387"/> <port id="pr_2db54a86-2c7a-4c81-b1d3-ed5e494210a1_p2" x="8333.0" y="2823.4387"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_73cdda19-5887-46b9-82bf-978fd1f39495"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18974095 in HEK293, in vitro by DAPK1 (DAPK1 phosphorylation status not assessed) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8283.75" y="2840.5312"/> <port id="pr_73cdda19-5887-46b9-82bf-978fd1f39495_p1" x="8303.75" y="2845.5312"/> <port id="pr_73cdda19-5887-46b9-82bf-978fd1f39495_p2" x="8273.75" y="2845.5312"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5448cdcd-9bed-4aaa-99af-11f4072176e2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18974095 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8640.49" y="3224.9502"/> <port id="pr_5448cdcd-9bed-4aaa-99af-11f4072176e2_p1" x="8645.49" y="3244.9502"/> <port id="pr_5448cdcd-9bed-4aaa-99af-11f4072176e2_p2" x="8645.49" y="3214.9502"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cc5e590a-fd96-42e6-b8f4-86978e3fb197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16959574 in different murine cell lines, inhibited upon Wnt signalling in HEK293 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8676.75" y="2811.6665"/> <port id="pr_cc5e590a-fd96-42e6-b8f4-86978e3fb197_p1" x="8666.75" y="2816.6665"/> <port id="pr_cc5e590a-fd96-42e6-b8f4-86978e3fb197_p2" x="8696.75" y="2816.6665"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_55f1268c-624a-4aa1-b709-b8691057a24f"> <bbox w="10.0" h="10.0" x="8705.0" y="2915.15"/> <port id="pr_55f1268c-624a-4aa1-b709-b8691057a24f_p1" x="8725.0" y="2920.15"/> <port id="pr_55f1268c-624a-4aa1-b709-b8691057a24f_p2" x="8695.0" y="2920.15"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_af82a535-ada2-4d79-b7d8-dbf8a588f7cd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19339977 review PMID:12869586 PMID:12906785 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8920.5" y="3053.5"/> <port id="pr_af82a535-ada2-4d79-b7d8-dbf8a588f7cd_p1" x="8940.5" y="3058.5"/> <port id="pr_af82a535-ada2-4d79-b7d8-dbf8a588f7cd_p2" x="8910.5" y="3058.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_331d0e3c-a4e4-4d3f-829e-8095e8f88dd8"> <bbox w="10.0" h="10.0" x="8920.5" y="3006.5"/> <port id="pr_331d0e3c-a4e4-4d3f-829e-8095e8f88dd8_p1" x="8910.5" y="3011.5"/> <port id="pr_331d0e3c-a4e4-4d3f-829e-8095e8f88dd8_p2" x="8940.5" y="3011.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_51572f19-dc50-4987-bb83-a396f9f13126"> <bbox w="10.0" h="10.0" x="9116.832" y="2570.326"/> <port id="pr_51572f19-dc50-4987-bb83-a396f9f13126_p1" x="9106.832" y="2575.326"/> <port id="pr_51572f19-dc50-4987-bb83-a396f9f13126_p2" x="9136.832" y="2575.326"/> </glyph> <glyph class="process" orientation="vertical" id="pr_30ca84a8-df5d-41f1-8c4c-f7250bcf55f3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: reactants to re PMID:18372248 PMID:17277771 PMID:17517883 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9256.832" y="2473.9927"/> <port id="pr_30ca84a8-df5d-41f1-8c4c-f7250bcf55f3_p1" x="9261.832" y="2493.9927"/> <port id="pr_30ca84a8-df5d-41f1-8c4c-f7250bcf55f3_p2" x="9261.832" y="2463.9927"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c3acb0a4-3f7e-4c44-b601-d416972a2647"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: logical:re369_s2093=FALSE References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8329.361" y="3718.8567"/> <port id="pr_c3acb0a4-3f7e-4c44-b601-d416972a2647_p1" x="8334.361" y="3738.8567"/> <port id="pr_c3acb0a4-3f7e-4c44-b601-d416972a2647_p2" x="8334.361" y="3708.8567"/> </glyph> <glyph class="process" orientation="vertical" id="pr_88737221-0b21-4eb9-a273-8892199144ce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18439900 in HEK293 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8800.75" y="2352.25"/> <port id="pr_88737221-0b21-4eb9-a273-8892199144ce_p1" x="8805.75" y="2372.25"/> <port id="pr_88737221-0b21-4eb9-a273-8892199144ce_p2" x="8805.75" y="2342.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d44bf5df-8cce-4f48-bfcc-ce32e5aac204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants engagement of mTOR in mTORC1 does not titrate it out of mTORC2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9076.232" y="2382.0"/> <port id="pr_d44bf5df-8cce-4f48-bfcc-ce32e5aac204_p1" x="9081.232" y="2372.0"/> <port id="pr_d44bf5df-8cce-4f48-bfcc-ce32e5aac204_p2" x="9081.232" y="2402.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0bb472a0-a88c-4dd4-aa23-1cb4383068f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: logical:re372_s2093=FALSE PMID:18439900 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8629.199" y="2216.1628"/> <port id="pr_0bb472a0-a88c-4dd4-aa23-1cb4383068f6_p1" x="8634.199" y="2236.1628"/> <port id="pr_0bb472a0-a88c-4dd4-aa23-1cb4383068f6_p2" x="8634.199" y="2206.1628"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e50b610c-418f-41af-b49d-9a189905e41b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19339977 review proposed RSK mediated phosphorylation of RAPTOR might provide a mechanism to overcome the inhibitory effect of AKT1S1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8995.375" y="2680.0"/> <port 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orientation="horizontal" id="pr_269d4315-7867-4b5f-911f-9d67517d0af5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9465032 PMID:12087098 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9490.5" y="3142.5"/> <port id="pr_269d4315-7867-4b5f-911f-9d67517d0af5_p1" x="9480.5" y="3147.5"/> <port id="pr_269d4315-7867-4b5f-911f-9d67517d0af5_p2" x="9510.5" y="3147.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_71d6f2e5-e9a7-44d3-8ca0-fca04bc2315f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9465032 PMID:15690031 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9935.5" y="3150.5"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12482958 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9727.0" y="3263.0"/> <port id="pr_9fb3348e-b013-45fc-bc9a-ff2179fa29db_p1" x="9732.0" y="3253.0"/> <port id="pr_9fb3348e-b013-45fc-bc9a-ff2179fa29db_p2" x="9732.0" y="3283.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2c64adb8-d3c3-4888-854f-809ef24d6e02"> <bbox w="10.0" h="10.0" x="9447.5" y="3278.5"/> <port id="pr_2c64adb8-d3c3-4888-854f-809ef24d6e02_p1" x="9437.5" y="3283.5"/> <port id="pr_2c64adb8-d3c3-4888-854f-809ef24d6e02_p2" x="9467.5" y="3283.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_690246ce-14f3-4a12-90be-d58d0a24c760"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15105421 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id="pr_539f3a88-88c7-40c5-aafe-abb348c562b3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12702559 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7541.5" y="5920.75"/> <port id="pr_539f3a88-88c7-40c5-aafe-abb348c562b3_p1" x="7546.5" y="5910.75"/> <port id="pr_539f3a88-88c7-40c5-aafe-abb348c562b3_p2" x="7546.5" y="5940.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5a4246dc-5c17-4630-9aaf-abe7256bbc0f"> <bbox w="10.0" h="10.0" x="7320.0" y="6045.0"/> <port id="pr_5a4246dc-5c17-4630-9aaf-abe7256bbc0f_p1" x="7310.0" y="6050.0"/> <port id="pr_5a4246dc-5c17-4630-9aaf-abe7256bbc0f_p2" x="7340.0" y="6050.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ec586d56-2be1-4756-a27a-cc0d3b2776aa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9632793 in vitro techniques for proteine-DNA interactions, using Hela extracts and synthetic DNA from LDHA promoter References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5770.5" y="7650.0"/> <port id="pr_ec586d56-2be1-4756-a27a-cc0d3b2776aa_p1" x="5790.5" y="7655.0"/> <port id="pr_ec586d56-2be1-4756-a27a-cc0d3b2776aa_p2" x="5760.5" y="7655.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6d9e93d6-0252-423a-ab5b-e6087e85ad27"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11641274 PMID:12080085 PMID:12042299 PMID:12215170 PMID:22841746 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5907.5" y="7780.0"/> <port id="pr_6d9e93d6-0252-423a-ab5b-e6087e85ad27_p1" x="5912.5" y="7770.0"/> <port id="pr_6d9e93d6-0252-423a-ab5b-e6087e85ad27_p2" x="5912.5" y="7800.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_09917271-2797-429a-b658-f508aa018a56"> <bbox w="20.0" h="20.0" x="6069.88" y="7769.99"/> <port id="logicglyph_09917271-2797-429a-b658-f508aa018a56_p1" x="6099.88" y="7779.99"/> <port id="logicglyph_09917271-2797-429a-b658-f508aa018a56_p2" x="6059.88" y="7779.99"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7aa13a33-0d25-4ddc-bbba-fcb63e430a67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18838541 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6077.5" y="7560.0"/> <port id="pr_7aa13a33-0d25-4ddc-bbba-fcb63e430a67_p1" x="6082.5" y="7580.0"/> 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x="10802.0" y="1540.541"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1c73b4ea-a71f-40c4-ab36-975a3fce6ccb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10783894 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4721.413" y="7204.75"/> <port id="pr_1c73b4ea-a71f-40c4-ab36-975a3fce6ccb_p1" x="4726.413" y="7224.75"/> <port id="pr_1c73b4ea-a71f-40c4-ab36-975a3fce6ccb_p2" x="4726.413" y="7194.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2cbda736-a206-461a-a6bf-0f505aa13741"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18521080 in human hepatocellular carcinoma References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4727.1406" y="7367.4434"/> <port id="pr_2cbda736-a206-461a-a6bf-0f505aa13741_p1" x="4732.1406" y="7357.4434"/> <port id="pr_2cbda736-a206-461a-a6bf-0f505aa13741_p2" x="4732.1406" y="7387.4434"/> </glyph> <glyph class="process" orientation="vertical" id="pr_48aeb1fc-6469-4c30-957c-a409769b08f3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9765397 PMID:10604474 PMID:16179260 PMID:17106237 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9820.116" y="2169.0"/> <port id="pr_48aeb1fc-6469-4c30-957c-a409769b08f3_p1" x="9825.116" y="2189.0"/> <port id="pr_48aeb1fc-6469-4c30-957c-a409769b08f3_p2" x="9825.116" y="2159.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3113bbcb-238f-4134-80ad-416e1f558a09"> <notes> <html 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18677096 >From abstract (no acces to the article) interaction BIM (all 3 major isoforms) - MIF in vitro and in HEK293 and K562 immortalised human myelogenous leukaemia cell line (bcr:abl positive). MIF displays negative effect on BIM mediated apoptosis when over-expressed. MIF targeting siRNA in K562 increases diamide-induced apoptosis. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4338.185" y="2887.875"/> <port id="pr_2fa655a9-4fca-4970-bb72-d2307c146df6_p1" x="4343.185" y="2907.875"/> <port id="pr_2fa655a9-4fca-4970-bb72-d2307c146df6_p2" x="4343.185" y="2877.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_52712946-1b0b-4a4e-9460-65fac34de4c5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12591950 in vitro, phosphorylation of BimL by JNK, mutant Bim used for identification of phospho-sites in 293T upon UV radiations References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5082.4766" y="3248.9902"/> <port id="pr_52712946-1b0b-4a4e-9460-65fac34de4c5_p1" x="5072.4766" y="3253.9902"/> <port id="pr_52712946-1b0b-4a4e-9460-65fac34de4c5_p2" x="5102.4766" y="3253.9902"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ce297b11-ccd5-4c61-943d-645dec80b913"> <bbox w="10.0" h="10.0" x="4902.117" y="3099.6152"/> <port id="pr_ce297b11-ccd5-4c61-943d-645dec80b913_p1" x="4907.117" y="3089.6152"/> <port id="pr_ce297b11-ccd5-4c61-943d-645dec80b913_p2" x="4907.117" y="3119.6152"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cac1a1d7-ba1d-4180-a2eb-94a8c395c0f2"> <bbox w="10.0" h="10.0" x="5139.1357" y="3100.2085"/> <port id="pr_cac1a1d7-ba1d-4180-a2eb-94a8c395c0f2_p1" x="5144.1357" y="3120.2085"/> <port id="pr_cac1a1d7-ba1d-4180-a2eb-94a8c395c0f2_p2" x="5144.1357" y="3090.2085"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9e2a0972-919e-4437-a259-fe88a0e953da"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4892.167" y="2954.2085"/> <port id="pr_9e2a0972-919e-4437-a259-fe88a0e953da_p1" x="4912.167" y="2959.2085"/> <port id="pr_9e2a0972-919e-4437-a259-fe88a0e953da_p2" x="4882.167" y="2959.2085"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f10108cd-22ea-4c36-b81f-85f00039085e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12646560 in CCL39 chinese hamster lung fibroblast cell line PMID:15486085 in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim) in vitro, ERK2 phosphorylates mouse BimEL in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated. PMID:19150432 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4811.167" y="2819.3335"/> <port id="pr_f10108cd-22ea-4c36-b81f-85f00039085e_p1" x="4801.167" y="2824.3335"/> <port id="pr_f10108cd-22ea-4c36-b81f-85f00039085e_p2" x="4831.167" y="2824.3335"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17b9c4a0-3564-48a3-9328-89a4a4e0d5e2"> <bbox w="10.0" h="10.0" x="4811.167" y="2799.3335"/> <port id="pr_17b9c4a0-3564-48a3-9328-89a4a4e0d5e2_p1" x="4831.167" y="2804.3335"/> <port id="pr_17b9c4a0-3564-48a3-9328-89a4a4e0d5e2_p2" x="4801.167" y="2804.3335"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_de414e0f-9d55-4831-9875-c1c06bee5a08"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19150432 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5145.2373" y="2807.37"/> <port id="pr_de414e0f-9d55-4831-9875-c1c06bee5a08_p1" x="5135.2373" y="2812.37"/> <port id="pr_de414e0f-9d55-4831-9875-c1c06bee5a08_p2" x="5165.2373" y="2812.37"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9ee781d0-e425-4903-b3ea-62e6dc615fc5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19150432 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4985.8335" y="2817.3335"/> <port id="pr_9ee781d0-e425-4903-b3ea-62e6dc615fc5_p1" x="4975.8335" y="2822.3335"/> <port id="pr_9ee781d0-e425-4903-b3ea-62e6dc615fc5_p2" x="5005.8335" y="2822.3335"/> </glyph> <glyph class="process" orientation="vertical" id="pr_da32c281-128c-4474-84c4-c57b22a40ece"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4703.148" y="3048.375"/> <port id="pr_da32c281-128c-4474-84c4-c57b22a40ece_p1" x="4708.148" y="3038.375"/> <port id="pr_da32c281-128c-4474-84c4-c57b22a40ece_p2" x="4708.148" y="3068.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8f6736ef-ec97-4273-9fec-423bd347601c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4772.25" y="2954.375"/> <port id="pr_8f6736ef-ec97-4273-9fec-423bd347601c_p1" x="4777.25" y="2944.375"/> <port id="pr_8f6736ef-ec97-4273-9fec-423bd347601c_p2" x="4777.25" y="2974.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8dfc14d7-9488-4a26-8043-b78897768607"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16282323 in murine BA/F3 IL3-dependent cells, multisite phosphorylation of BimEL upon IL3. Attenuated by ERK and PI3K inhibitors. in vitro, active mouse Akt purified from IL3 treated BAF3 cells phosphorylates recombinant human BimEL. Blocked by mutation of S87 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4729.0" y="2732.0"/> <port id="pr_8dfc14d7-9488-4a26-8043-b78897768607_p1" x="4734.0" y="2752.0"/> <port id="pr_8dfc14d7-9488-4a26-8043-b78897768607_p2" x="4734.0" y="2722.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_daf84941-ebcb-4ac2-8d81-933079fa079c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16282323 in HepG3 cells, insulin activates Akt but not ERK, and induces interaction between 14-3-3 and Bim (IP). In the same cell line, BimEL S87 phosphorylation was not assessed. The authors propose that the 14-3-3 bind to Akt-phosphorylated BimEL References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4656.3135" y="2612.9617"/> <port id="pr_daf84941-ebcb-4ac2-8d81-933079fa079c_p1" x="4676.3135" y="2617.9617"/> <port id="pr_daf84941-ebcb-4ac2-8d81-933079fa079c_p2" x="4646.3135" y="2617.9617"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a23f8c16-9cd2-4b32-b418-f07ebbf8e3a9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18420585 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4508.7617" y="3282.7014"/> <port id="pr_a23f8c16-9cd2-4b32-b418-f07ebbf8e3a9_p1" x="4528.7617" y="3287.7014"/> <port id="pr_a23f8c16-9cd2-4b32-b418-f07ebbf8e3a9_p2" x="4498.7617" y="3287.7014"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_245b0d34-fbc5-4089-8b88-aa00f0f98e8b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18420585 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4584.5" y="2810.0"/> <port id="pr_245b0d34-fbc5-4089-8b88-aa00f0f98e8b_p1" x="4604.5" y="2815.0"/> <port id="pr_245b0d34-fbc5-4089-8b88-aa00f0f98e8b_p2" x="4574.5" y="2815.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_04d952b4-9200-4c8c-bcc0-15c2fc05bf39"> <bbox w="10.0" h="10.0" x="4613.2974" y="3220.3943"/> <port id="pr_04d952b4-9200-4c8c-bcc0-15c2fc05bf39_p1" x="4618.2974" y="3210.3943"/> <port id="pr_04d952b4-9200-4c8c-bcc0-15c2fc05bf39_p2" x="4618.2974" y="3240.3943"/> </glyph> <glyph class="process" orientation="vertical" id="pr_85faaabc-c373-47be-b1b8-8f230d415bcd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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<notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16508011 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3880.0" y="7670.0"/> <port id="pr_cb4b3dde-c687-41cc-aba0-2d2e9b3723c2_p1" x="3870.0" y="7675.0"/> <port id="pr_cb4b3dde-c687-41cc-aba0-2d2e9b3723c2_p2" x="3900.0" y="7675.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_010427e2-a9aa-440b-925f-bf1a15bdc070"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15708980 in H1299 by HIPK2 upon UV PMID:16984892 in vitro in H1299 upon JNK1 sustained activation (ectopic expression, UV or cisPlatin, in COS7), by JNK in MEFs upon UV, but not in JNK1 KO MEFs 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<head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3572.5" y="7670.0"/> <port id="pr_abe535a8-5437-4251-a4a7-2db5825d05ea_p1" x="3562.5" y="7675.0"/> <port id="pr_abe535a8-5437-4251-a4a7-2db5825d05ea_p2" x="3592.5" y="7675.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4a227b20-0f41-4d06-953d-c18b9ad57ec0"> <bbox w="10.0" h="10.0" x="2831.789" y="6978.31"/> <port id="pr_4a227b20-0f41-4d06-953d-c18b9ad57ec0_p1" x="2836.789" y="6998.31"/> <port id="pr_4a227b20-0f41-4d06-953d-c18b9ad57ec0_p2" x="2836.789" y="6968.31"/> </glyph> <glyph class="process" orientation="vertical" id="pr_39df7cf6-8e26-4012-b243-1f9ee17c9a1e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15753124 in CHO cell with overexpressed human insulin 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positive influence on apoptosome assembly PMID:18439902 CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6693.75" y="5731.25"/> <port id="pr_1ca72379-795e-4708-9896-20b431f898dd_p1" x="6683.75" y="5736.25"/> <port id="pr_1ca72379-795e-4708-9896-20b431f898dd_p2" x="6713.75" y="5736.25"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_304bf01d-e89a-46d6-8857-d2ab7c77929f"> <bbox w="20.0" h="20.0" x="6556.882" y="5950.1714"/> <port id="logicglyph_304bf01d-e89a-46d6-8857-d2ab7c77929f_p1" x="6566.882" y="5980.1714"/> <port id="logicglyph_304bf01d-e89a-46d6-8857-d2ab7c77929f_p2" x="6566.882" y="5940.1714"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f9d79af6-85b3-4593-ab9d-72a0e2d5decd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10980706 PMID:10544189 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6546.5312" y="5626.0"/> <port id="pr_f9d79af6-85b3-4593-ab9d-72a0e2d5decd_p1" x="6551.5312" y="5646.0"/> <port id="pr_f9d79af6-85b3-4593-ab9d-72a0e2d5decd_p2" x="6551.5312" y="5616.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_eba1f78b-9737-4652-888a-24315856d16d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15210107 reviews the differerent hypothesis concerning the biochemical events leading to activation of CASP9 PMID:12773388 in vitro, survivin and HBXIP together inhibits CASP9 processing and activation in HT1080 cells, coexpression of BIRC5 and HBXIP suppresses staurosporin-induced apoptosis in cell extracts from Hela transfected with siRNA against HBXIP, CYCS induced caspase activation is suppressed PMID:10329646 by NOD1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6920.0" y="5415.0"/> <port id="pr_eba1f78b-9737-4652-888a-24315856d16d_p1" x="6910.0" y="5420.0"/> <port id="pr_eba1f78b-9737-4652-888a-24315856d16d_p2" x="6940.0" y="5420.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9287b036-275a-48cb-8a09-058723b5bd48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10949025 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6947.0" y="6115.0"/> <port id="pr_9287b036-275a-48cb-8a09-058723b5bd48_p1" x="6937.0" y="6120.0"/> <port id="pr_9287b036-275a-48cb-8a09-058723b5bd48_p2" x="6967.0" y="6120.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_11ce9ec0-1b87-410c-9e7e-d204885585fe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10934467 in 293, HeLa and Jurkat cells, interaction HSP70 - APAF1 in vitro, the interaction is ATP dependent HSP70 interactions competes for oligomerization and formation of the apoptosome PMID:10934466 in vitro, HSP70 blocks the recruitment of CASP9 into the apoptosome by binding to APAF1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6802.0" y="6015.0"/> <port id="pr_11ce9ec0-1b87-410c-9e7e-d204885585fe_p1" x="6792.0" y="6020.0"/> <port id="pr_11ce9ec0-1b87-410c-9e7e-d204885585fe_p2" x="6822.0" y="6020.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_07a53d76-9de8-4325-9196-0ddfad19cb53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15262985 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6622.0" y="6125.0"/> <port id="pr_07a53d76-9de8-4325-9196-0ddfad19cb53_p1" x="6612.0" y="6130.0"/> <port id="pr_07a53d76-9de8-4325-9196-0ddfad19cb53_p2" x="6642.0" y="6130.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b74cebeb-4182-4191-b148-0571f460519f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10944114 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6917.0" y="5884.75"/> <port id="pr_b74cebeb-4182-4191-b148-0571f460519f_p1" x="6907.0" y="5889.75"/> <port id="pr_b74cebeb-4182-4191-b148-0571f460519f_p2" x="6937.0" y="5889.75"/> </glyph> <glyph class="process" orientation="horizontal" 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PMID:9812896 in 267 and MDCK (dog) cell lines in vitro direct phosphorylation with human recombinant proteins References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7106.875" y="5276.25"/> <port id="pr_06808edd-b44f-4c2e-a862-b9d0a4802d2f_p1" x="7096.875" y="5281.25"/> <port id="pr_06808edd-b44f-4c2e-a862-b9d0a4802d2f_p2" x="7126.875" y="5281.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_89e5179a-c364-4fe9-abaf-cec16c80511d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6906.875" y="5346.25"/> <port id="pr_89e5179a-c364-4fe9-abaf-cec16c80511d_p1" x="6896.875" y="5351.25"/> <port id="pr_89e5179a-c364-4fe9-abaf-cec16c80511d_p2" x="6926.875" y="5351.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_848cef90-175e-4d55-a658-3afaff7c6dd9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16287866 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6860.667" y="4897.0"/> <port id="pr_848cef90-175e-4d55-a658-3afaff7c6dd9_p1" x="6850.667" y="4902.0"/> <port id="pr_848cef90-175e-4d55-a658-3afaff7c6dd9_p2" x="6880.667" y="4902.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_537e6801-4f2d-4adf-950a-d6977f40bec6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16287866 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6860.667" y="4917.0"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12792650 Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2 in Hela cells, interaction GST-CASP9 / ERK in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA PMID:17466630 CASP9 T125 phosphorylation by CCNB1:CDC2 comment: phosphorylation during mitosis, when nuclear envelope is broken down PMID:19081073 CASP9 T125 phosphorylation by DYRK1A PMID:19016842 PMID:19586613 CASP9 T125 phosphorylation by DYRK1A and p38 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6859.666" y="3811.2236"/> <port id="pr_2368483c-15ab-4c6c-9436-c5dae1de63a2_p1" x="6849.666" y="3816.2236"/> <port id="pr_2368483c-15ab-4c6c-9436-c5dae1de63a2_p2" x="6879.666" y="3816.2236"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d1f7a8d3-a2dc-4002-971e-843d424c06aa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12792650 okadaic acid PMID:16888006 in a murine T cell line stably transfected with the human IL2R, IL2 withdrawal induces PP1 alpha catalytic subunit PP1CA dephosphorylation and activation and CASP9 dephosphorylation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6859.666" y="3831.2236"/> <port id="pr_d1f7a8d3-a2dc-4002-971e-843d424c06aa_p1" x="6879.666" y="3836.2236"/> <port id="pr_d1f7a8d3-a2dc-4002-971e-843d424c06aa_p2" x="6849.666" y="3836.2236"/> </glyph> <glyph class="process" orientation="vertical" id="pr_006c0274-3351-440e-ac1d-06c741f4616d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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<notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12620238 cristal structure of the complex References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6687.0" y="5178.5"/> <port id="pr_a4d8802f-28b7-4fc8-b9e5-69a82d5e1e37_p1" x="6677.0" y="5183.5"/> <port id="pr_a4d8802f-28b7-4fc8-b9e5-69a82d5e1e37_p2" x="6707.0" y="5183.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b7e1535a-207a-4c87-81f1-fb7b77ec3431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10671558 in vitro with recombinant proteins cleavage of recombinant CASP9 by cellular extract, in a Ca2+ dose-dependent manner in Hela cell extracts, preincubation with Ca2+ and CAPN2 prevents Cyt_c-mediated CASP3 cleavage in SH-SY5Y human neuroblastoma cells Ca2+ ionophore (A23187) treatment CAPN2-cleaved CASP9 is inactive CASP78 are also cleaved by CAPN2, but the effect on their activity is unknown References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6615.0" y="5082.5"/> <port id="pr_b7e1535a-207a-4c87-81f1-fb7b77ec3431_p1" x="6620.0" y="5102.5"/> <port id="pr_b7e1535a-207a-4c87-81f1-fb7b77ec3431_p2" x="6620.0" y="5072.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c1ea674d-7f03-4057-b974-210503115df9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4712.13" y="3141.75"/> <port id="pr_c1ea674d-7f03-4057-b974-210503115df9_p1" x="4717.13" y="3131.75"/> <port 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PMID:11085742 in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria PMID:10364179 cleavage of BID by CASP8 and CASP3 PMID:11832478 in vitro by CASP2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6778.125" y="2485.9048"/> <port id="pr_6ddc6182-664a-4318-ac7b-4dbb66e260a2_p1" x="6768.125" y="2490.9048"/> <port id="pr_6ddc6182-664a-4318-ac7b-4dbb66e260a2_p2" x="6798.125" y="2490.9048"/> </glyph> <glyph class="or" orientation="vertical" id="logicglyph_95799f51-7f03-466a-8015-aab8c80bdf4c"> <bbox w="20.0" h="20.0" x="6801.5747" y="2424.2456"/> <port id="logicglyph_95799f51-7f03-466a-8015-aab8c80bdf4c_p1" x="6811.5747" y="2414.2456"/> <port id="logicglyph_95799f51-7f03-466a-8015-aab8c80bdf4c_p2" x="6811.5747" y="2454.2456"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5717161a-a1d1-4596-9352-f189c9063a9f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11583622 BID phosphorylated in Hela, in L929 (murine fibrosarcoma cell line), in other cell lines mass spectrometry analysis of BID phosphorylated in vitro by Jurkat or Hela extracts mutagenesis experiments identifies S61 and S64 as the main phosphorylation site purification of kinase activity in 3 different chromatography fractions CSNK inhibits Fas-induced apoptosis in Hela D98/AH2 (Fas sensitive Hela) PMID:12598529 by CSNK2 at T59 PMID:20356928 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6661.3994" y="2548.25"/> <port id="pr_5717161a-a1d1-4596-9352-f189c9063a9f_p1" x="6666.3994" y="2538.25"/> <port id="pr_5717161a-a1d1-4596-9352-f189c9063a9f_p2" x="6666.3994" y="2568.25"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_771eb00c-7db9-45fb-b262-c8687435cfb6"> <bbox w="20.0" h="20.0" x="6607.076" y="2533.621"/> <port id="logicglyph_771eb00c-7db9-45fb-b262-c8687435cfb6_p1" x="6597.076" y="2543.621"/> <port id="logicglyph_771eb00c-7db9-45fb-b262-c8687435cfb6_p2" x="6637.076" y="2543.621"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a43f9558-48c4-44a6-b0e2-019f3dafd500"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6777.5" y="2547.0"/> <port id="pr_a43f9558-48c4-44a6-b0e2-019f3dafd500_p1" x="6767.5" y="2552.0"/> <port id="pr_a43f9558-48c4-44a6-b0e2-019f3dafd500_p2" x="6797.5" y="2552.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_aa030827-6bfa-4267-b1b4-bfb9e70e8430"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6777.625" y="2608.4897"/> <port id="pr_aa030827-6bfa-4267-b1b4-bfb9e70e8430_p1" x="6767.625" y="2613.4897"/> <port id="pr_aa030827-6bfa-4267-b1b4-bfb9e70e8430_p2" x="6797.625" y="2613.4897"/> </glyph> <glyph class="process" orientation="vertical" id="pr_62d3225e-8db0-40d1-8e54-9a06b4428651"> <bbox w="10.0" h="10.0" x="5210.243" y="4766.5"/> <port id="pr_62d3225e-8db0-40d1-8e54-9a06b4428651_p1" x="5215.243" y="4786.5"/> <port id="pr_62d3225e-8db0-40d1-8e54-9a06b4428651_p2" x="5215.243" y="4756.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ffe50881-c9b6-4183-83f7-94ffd7c565bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11583622 in vitro, phosphorylation of BID has no effect on Granzyme B mediated cleavage References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6782.77" y="2557.5"/> <port id="pr_ffe50881-c9b6-4183-83f7-94ffd7c565bc_p1" x="6772.77" y="2562.5"/> <port id="pr_ffe50881-c9b6-4183-83f7-94ffd7c565bc_p2" x="6802.77" y="2562.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9199a3b2-8a77-4d20-955d-6327d7a201b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11940658 in vitro cleavage of BID by m-calpain in human metastatic melanoma cell line, 224, in CASP3 deficient MCF-7 breast carcinoma cells, cleavage of BID by calpains and apoptosis in response to cisplatin use of calpain inhibitors involvment of mu-calpain cannot be ruled out PMID:11404357 in rabbit heart mounted onto a Langendorff's perfusion apparatus, upon ischemia/reperfusion, cleavage of BID by calpains in vitro cleavage of BID by recombinant mu-calpain PMID:17264306 in human neutrophils, upon bacteria-induced lysosomal permeabilization, BID cleavage and apoptosis are reversed by cathepsin but not caspase inhibition PMID:18469004 in different human cell lines (HeLa, MCF-7, SH-SY5Y, HaCaT, CaCo-2,HepG2), upon LeuLeuOMe-induced lysosomal membrane permeabilisation, cleavage of Bid and apoptosis, rescued by E-64d cathepsin inhibitor References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6894.375" y="2546.25"/> <port id="pr_9199a3b2-8a77-4d20-955d-6327d7a201b2_p1" x="6899.375" y="2566.25"/> <port id="pr_9199a3b2-8a77-4d20-955d-6327d7a201b2_p2" x="6899.375" y="2536.25"/> </glyph> <glyph class="or" orientation="vertical" id="logicglyph_7b06072f-fe3f-4a44-b408-8a8713b26109"> <bbox w="20.0" h="20.0" x="6860.7295" y="2450.7927"/> <port id="logicglyph_7b06072f-fe3f-4a44-b408-8a8713b26109_p1" x="6870.7295" y="2440.7927"/> <port id="logicglyph_7b06072f-fe3f-4a44-b408-8a8713b26109_p2" x="6870.7295" y="2480.7927"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_92f09587-e24a-450b-9487-469fdac3575d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11099414 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7005.0" y="2485.0"/> <port id="pr_92f09587-e24a-450b-9487-469fdac3575d_p1" x="6995.0" y="2490.0"/> <port id="pr_92f09587-e24a-450b-9487-469fdac3575d_p2" x="7025.0" y="2490.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_96ce8339-d030-40ba-90e3-8948d623d1cb"> <bbox w="10.0" h="10.0" x="5790.4023" y="3301.5"/> <port id="pr_96ce8339-d030-40ba-90e3-8948d623d1cb_p1" x="5810.4023" y="3306.5"/> <port id="pr_96ce8339-d030-40ba-90e3-8948d623d1cb_p2" x="5780.4023" y="3306.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_459f6e99-4305-4823-9a68-e25450eb66de"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14687661 in NIH3T3 mouse embryonic fibroblasts over-expression of human HSP90B1 protects from TNF+CHX-induced apoptosis co-IP experiments in same cells (not very convincing) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6607.964" y="2686.074"/> <port id="pr_459f6e99-4305-4823-9a68-e25450eb66de_p1" x="6627.964" y="2691.074"/> <port id="pr_459f6e99-4305-4823-9a68-e25450eb66de_p2" x="6597.964" y="2691.074"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_84c2336b-898e-4db8-9bf9-9f0ceb7cb0fc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17053147 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9543.449" y="3477.226"/> <port id="pr_84c2336b-898e-4db8-9bf9-9f0ceb7cb0fc_p1" x="9533.449" y="3482.226"/> <port id="pr_84c2336b-898e-4db8-9bf9-9f0ceb7cb0fc_p2" x="9563.449" y="3482.226"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1c5a0367-c14f-449e-b622-c3b5bb046ae7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17053147 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9751.027" y="3477.7634"/> <port id="pr_1c5a0367-c14f-449e-b622-c3b5bb046ae7_p1" x="9741.027" y="3482.7634"/> <port id="pr_1c5a0367-c14f-449e-b622-c3b5bb046ae7_p2" x="9771.027" y="3482.7634"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_49149bb6-e13e-4525-804c-18883a39950e"> <bbox w="10.0" h="10.0" x="9910.027" y="3477.2634"/> <port id="pr_49149bb6-e13e-4525-804c-18883a39950e_p1" x="9900.027" y="3482.2634"/> <port id="pr_49149bb6-e13e-4525-804c-18883a39950e_p2" x="9930.027" y="3482.2634"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b8f4302e-e227-496d-a7f7-a7c91ff7a4c4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17928295 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8956.0" y="3270.4783"/> <port id="pr_b8f4302e-e227-496d-a7f7-a7c91ff7a4c4_p1" x="8946.0" y="3275.4783"/> <port id="pr_b8f4302e-e227-496d-a7f7-a7c91ff7a4c4_p2" x="8976.0" y="3275.4783"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_88d283c9-2412-4584-baa6-a846b2cb277b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reviewed in the uniprot entries for PDP1 and PDPR References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2022.8823" y="5903.4585"/> <port id="pr_88d283c9-2412-4584-baa6-a846b2cb277b_p1" x="2042.8823" y="5908.4585"/> <port id="pr_88d283c9-2412-4584-baa6-a846b2cb277b_p2" x="2012.8823" y="5908.4585"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5b123009-5e23-4221-80a4-1d4ffbb3e1ba"> <bbox w="10.0" h="10.0" x="3451.262" y="6979.185"/> <port id="pr_5b123009-5e23-4221-80a4-1d4ffbb3e1ba_p1" x="3456.262" y="6999.185"/> <port id="pr_5b123009-5e23-4221-80a4-1d4ffbb3e1ba_p2" x="3456.262" y="6969.185"/> </glyph> <glyph class="process" orientation="vertical" id="pr_623b4671-d7db-4cb5-b8b3-b1a84c3a09c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19581926 in vitro, SCF FBXO45 complex ubiquitinates TP73 in SH-5YSY neuroblastoma cells, FBXO45 mediates proteasome dependent degradation of TP73 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3487.5" y="7640.0"/> <port id="pr_623b4671-d7db-4cb5-b8b3-b1a84c3a09c7_p1" x="3492.5" y="7630.0"/> <port id="pr_623b4671-d7db-4cb5-b8b3-b1a84c3a09c7_p2" x="3492.5" y="7660.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_577d56d7-2847-4b1c-85ae-1e424509eb15"> <bbox w="10.0" h="10.0" x="4490.7227" y="6979.685"/> <port id="pr_577d56d7-2847-4b1c-85ae-1e424509eb15_p1" x="4495.7227" y="6999.685"/> <port id="pr_577d56d7-2847-4b1c-85ae-1e424509eb15_p2" x="4495.7227" y="6969.685"/> </glyph> <glyph 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class="process" orientation="horizontal" id="pr_ba6d07bd-8ff3-479d-99b4-b10d687da6c8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9430630 PMID:15486085 BCL2-BimEL interaction in mitochondrial fraction independent of BIM S69 phosphorylation status PMID:15724238 in human tonsil B cells, constitutive interaction PMID:10198631 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4228.4375" y="4235.0"/> <port id="pr_ba6d07bd-8ff3-479d-99b4-b10d687da6c8_p1" x="4248.4375" y="4240.0"/> <port id="pr_ba6d07bd-8ff3-479d-99b4-b10d687da6c8_p2" x="4218.4375" y="4240.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_014683a6-ac9e-4269-ba15-5b59d5e599c5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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id="pr_f9ed1643-de6a-4da2-a060-7a8f48039206"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16608847 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4733.0" y="4365.323"/> <port id="pr_f9ed1643-de6a-4da2-a060-7a8f48039206_p1" x="4753.0" y="4370.323"/> <port id="pr_f9ed1643-de6a-4da2-a060-7a8f48039206_p2" x="4723.0" y="4370.323"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e8af3906-2093-4ab9-923a-ebac11a050a4"> <bbox w="10.0" h="10.0" x="4733.0" y="4505.0"/> <port id="pr_e8af3906-2093-4ab9-923a-ebac11a050a4_p1" x="4753.0" y="4510.0"/> <port id="pr_e8af3906-2093-4ab9-923a-ebac11a050a4_p2" x="4723.0" y="4510.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5bc08353-153c-46f9-94d5-29855345ae9c"> <bbox w="10.0" h="10.0" x="4733.0" y="4637.2812"/> <port 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y="5309.3877"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_58395cf3-8257-4196-8f2e-79bc0132bd02"> <bbox w="10.0" h="10.0" x="4348.0" y="5427.469"/> <port id="pr_58395cf3-8257-4196-8f2e-79bc0132bd02_p1" x="4368.0" y="5432.469"/> <port id="pr_58395cf3-8257-4196-8f2e-79bc0132bd02_p2" x="4338.0" y="5432.469"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ad8a7fe6-ccbd-41fc-8412-f34677b753ed"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11546872 in HEK293T, coIP Y2H References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5013.0" y="4234.6553"/> <port id="pr_ad8a7fe6-ccbd-41fc-8412-f34677b753ed_p1" x="5033.0" y="4239.6553"/> <port id="pr_ad8a7fe6-ccbd-41fc-8412-f34677b753ed_p2" x="5003.0" y="4239.6553"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fa1b9d88-7230-45ce-ad57-f510f4359d4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11546872 in HEK293T, coIP Y2H References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5013.0" y="4387.0547"/> <port id="pr_fa1b9d88-7230-45ce-ad57-f510f4359d4b_p1" x="5033.0" y="4392.0547"/> <port id="pr_fa1b9d88-7230-45ce-ad57-f510f4359d4b_p2" x="5003.0" y="4392.0547"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7249a564-418e-4c84-9d0a-275098ce89bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11546872 in HEK293T, coIP Y2H References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5013.0" y="4525.3447"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9130713 PMID:10075695 in 293T, IP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4753.4375" y="5164.827"/> <port id="pr_9140194f-f4af-4f02-9d11-ffe4215b172b_p1" x="4773.4375" y="5169.827"/> <port id="pr_9140194f-f4af-4f02-9d11-ffe4215b172b_p2" x="4743.4375" y="5169.827"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_34ae08e2-7e43-4999-8028-ffe33ac8a5b1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9130713 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4753.4375" y="4995.0"/> <port id="pr_34ae08e2-7e43-4999-8028-ffe33ac8a5b1_p1" x="4773.4375" y="5000.0"/> <port id="pr_34ae08e2-7e43-4999-8028-ffe33ac8a5b1_p2" x="4743.4375" y="5000.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a76eef13-f767-4c0f-9869-5f41d3d5ced4"> <bbox w="10.0" h="10.0" x="4398.0" y="5869.2495"/> <port id="pr_a76eef13-f767-4c0f-9869-5f41d3d5ced4_p1" x="4418.0" y="5874.2495"/> <port id="pr_a76eef13-f767-4c0f-9869-5f41d3d5ced4_p2" x="4388.0" y="5874.2495"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_026f3ee7-66ee-4c16-bc39-8d0513205b52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12687019 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7590.3823" y="7205.8994"/> <port id="pr_026f3ee7-66ee-4c16-bc39-8d0513205b52_p1" x="7580.3823" y="7210.8994"/> <port id="pr_026f3ee7-66ee-4c16-bc39-8d0513205b52_p2" x="7610.3823" y="7210.8994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4f908eef-cfdf-4801-b8c6-7188928457f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15031724 Y2H with human cDNA References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4759.375" y="5325.6562"/> <port id="pr_4f908eef-cfdf-4801-b8c6-7188928457f6_p1" x="4779.375" y="5330.6562"/> <port id="pr_4f908eef-cfdf-4801-b8c6-7188928457f6_p2" x="4749.375" y="5330.6562"/> </glyph> <glyph class="process" orientation="vertical" id="pr_578dd2f4-cfdc-4801-9720-d0d20be2404a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15031724 Y2H by Y2H and coIP a p32 mutant defective for interaction with HRK fails to target HRK to mitochondria and 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12049737 in vitro with recombinant murine proteines in COS cells with ectopic expression of BAD in rat granule neurons upon suppression of neuronal activity, cdc2 is induced, phosphorylates BAD S128 in rat neurones expressing ectopic proteins, cdc2 induced apoptosis is inhibited by a BAD S118 mutant in vitro, AKT mediated BAD S136 phosphorylation is not blocked by prior cdc2 mediated BAD S128 phosphorylations BAD S128 phosphorylation inhibits BAD phospho S136 : 14-3-3 interaction References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3086.625" y="3121.2666"/> <port id="pr_aaf694c2-253b-4992-861f-1aae06990f16_p1" x="3091.625" y="3111.2666"/> <port id="pr_aaf694c2-253b-4992-861f-1aae06990f16_p2" x="3091.625" y="3141.2666"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_845447eb-2474-454a-9128-78b88a708598"> <notes> <html 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mitochondria localized PKA is a BAD-S112(human S75) kinase PMID:10558990 in vitro purified activated RSK2/RPS6KA3 phosphorylates a peptide encompassing BAD S112(humanS75) phospho-site. Far less efficient as a BAD-S136 kinase in 293T, over-expression of RSK2 and MEK1 induces phsophorylation of BAD (anti-BAD pS112) in BDNF-treated cerebellar granule cells, BDNF induces S112 phosphorylation of BAD, in a MEK1-dependent manner (PD098059) PMID:10837486 RSK is a BAD S112 kinase (anti BAD-phosphoS112) in vitro, in HEK293 upon forskolin TPA isoproterenol or insulin-like growth factor, PKA mediated phosphorylation of S155 of murine BAD (human S118) S118 lies in the BH3 domain of BAD phosphorylation of S155 independent of that of S112/136 RSK1-2-3 are BAD S155 kinases PMID:12954615 in vitro, murine PIM2 immunoprecipitated from trasfected U2OS phosphorylates BAD in U2OS, PIM2 expression but not that of a kinase dead mutant induces BAD S112 phosphorylation in FDCP1 murine IL3 dependent hematopoietic cells, upon IL3 withdrawal or doxorubicin, PIM2 ectopic expression is protective PMID:15280015 BAD S112 phosphorylation by PIM1 PMID:17270021 in SW480 human colon carcinoma cell line, correlation between PIM3 expression and BAD phosphorylation. siRNA against PIM3 abrogates BAD S112 and S136 phosphorylation and induces apoptosis in a set of human colon cancers, correlation and colocalization of PIM3 and BAD phospho-S112 PMID:11493700 S6K purified as a BAD kinase from FL5.12 BCL-XL/BAD cells in vitro with recombinant proteins, BAD S136 phosphorylation in FL5.12 by S6K upon IGF, inhibited by rapamycin in ES p70S6K-/- cells, IGF-induced BAD S136 phosphorylation is lost PMID:10611223 in FL5.12 upon IL3, PAK1 phosphorylates BAD on S112 and S136, which results in decreased interaction with BCL2 and BCL2L1, and increased interaction with 14-3-3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3103.375" y="2934.9292"/> <port id="pr_845447eb-2474-454a-9128-78b88a708598_p1" x="3093.375" y="2939.9292"/> <port id="pr_845447eb-2474-454a-9128-78b88a708598_p2" x="3123.375" y="2939.9292"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f0b8eee9-fccd-45b9-9836-cde334f57af1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: logical:re632_s2093=FALSE PMID:10837486 interaction between BAD S155 and 14-3-3 delta and epsilon PMID:8929531 in FL5.12 co-IP of mouse BAD phosphorylated and YWHAQ in FL5.12 BAD phosphorylated only on S112 or S136 still binds 14-3-3 (S to A mutants, co-IP) in FL5.12 phosphorylation and binding to 14-3-3 inhibits BAD interaction with Bcl-XL and pro-apoptotic activity PMID:12657644 in 293T, BAD:YWHAE interaction, inhibited by caspase-mediated cleavage of YWHAE PMID:17979178 BAD:YWHAH interaction tandem affinity purification in a complex with Raf (cited by IntAct) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3295.0" y="3032.0"/> <port id="pr_f0b8eee9-fccd-45b9-9836-cde334f57af1_p1" x="3300.0" y="3022.0"/> 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relocalizes to mitochondria in response to cytoplasmic Ca2+ increased (THG, A23187) in primaryin primary rat hippocampal neurons, L-glutamate induces cell death and relocalization to mitochondria of BAD-GFP, which are both inhibited by co-expression of dominant negative DeltaCnA(H101Q) in 293T cells or 293T cells expressing mitochondria-targeted RAF1, upon over-expression of constitutive active calcineurin (DeltaCnA/CnB) References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3103.375" y="2954.9292"/> <port id="pr_6c1f1f4b-a125-4b65-9314-d778d15a8c55_p1" x="3123.375" y="2959.9292"/> <port id="pr_6c1f1f4b-a125-4b65-9314-d778d15a8c55_p2" x="3093.375" y="2959.9292"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4a150776-aa0b-42bf-a710-d55772ff0fdd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> 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<notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2850.25" y="2774.6084"/> <port id="pr_bc4bb394-22fa-4229-81c2-64ea35cb0ce1_p1" x="2840.25" y="2779.6084"/> <port id="pr_bc4bb394-22fa-4229-81c2-64ea35cb0ce1_p2" x="2870.25" y="2779.6084"/> </glyph> <glyph class="process" orientation="vertical" id="pr_041555c4-ccbc-49c4-be9a-3003146ed28e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a logical:re631_s3146_re638=FALSE logical:re633_s3146_re638=FALSE References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3144.375" y="3006.1958"/> <port 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12931191 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4270.0" y="3977.0"/> <port id="pr_8ac201ee-0cf5-4123-a44d-082a5f47eec2_p1" x="4260.0" y="3982.0"/> <port id="pr_8ac201ee-0cf5-4123-a44d-082a5f47eec2_p2" x="4290.0" y="3982.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c71f76c0-b170-407d-a06c-4260d42325fb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12931191 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4270.0" y="3935.0"/> <port id="pr_c71f76c0-b170-407d-a06c-4260d42325fb_p1" x="4290.0" y="3940.0"/> <port id="pr_c71f76c0-b170-407d-a06c-4260d42325fb_p2" x="4260.0" y="3940.0"/> 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id="pr_c760549e-02a1-4e16-9be2-d14a1b96b555"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11331593 in in FDCP-Mix and FL5.12 hematopoietic progenitor cells, by DREAM/KCNIP3 inhibition released upon IL3 withdrawal PMID:12217801 in Jurkat, upon Fas References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4517.7925" y="7202.75"/> <port id="pr_c760549e-02a1-4e16-9be2-d14a1b96b555_p1" x="4522.7925" y="7222.75"/> <port id="pr_c760549e-02a1-4e16-9be2-d14a1b96b555_p2" x="4522.7925" y="7192.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e6cd812a-3def-48ef-b089-5a65bc515710"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP reactionType:casp.cleavage PMID:11741536 in MCF7 upon TNF in Hela upon TNF + CHX References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5352.0" y="1277.0"/> <port id="pr_e6cd812a-3def-48ef-b089-5a65bc515710_p1" x="5357.0" y="1267.0"/> <port id="pr_e6cd812a-3def-48ef-b089-5a65bc515710_p2" x="5357.0" y="1297.0"/> </glyph> <glyph class="or" orientation="vertical" id="logicglyph_de158fd7-9d13-47f4-b45b-43b7776fb496"> <bbox w="20.0" h="20.0" x="7290.149" y="4724.7075"/> <port id="logicglyph_de158fd7-9d13-47f4-b45b-43b7776fb496_p1" x="7300.149" y="4754.7075"/> <port id="logicglyph_de158fd7-9d13-47f4-b45b-43b7776fb496_p2" x="7300.149" y="4714.7075"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_78e63a9b-be82-40dd-9c93-7cffe4030ce5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: in vitro by CASP3, CASP7, CASP8 in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavagePMID:23377657 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10352.75" y="2665.0"/> <port id="pr_78e63a9b-be82-40dd-9c93-7cffe4030ce5_p1" x="10342.75" y="2670.0"/> <port id="pr_78e63a9b-be82-40dd-9c93-7cffe4030ce5_p2" x="10372.75" y="2670.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_db723fb4-264b-4587-9858-06cacfbd323f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: in vitro by CASP3, CASP7, CASP8 in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage in Ba/F3 upon doxorubicin or etoposide or anti-FasPMID:23377657 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10232.5" y="2477.5"/> <port id="pr_db723fb4-264b-4587-9858-06cacfbd323f_p1" x="10222.5" y="2482.5"/> <port id="pr_db723fb4-264b-4587-9858-06cacfbd323f_p2" x="10252.5" y="2482.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2ed9d80e-fd93-431a-b86c-bd4a9fcfc8e8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: in Ba/F3 upon IL3 deprivation (cell fractionation) in Hela expressing the tagged C-terminal cleavage product of BECN1 (microscopy)PMID:23377657 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7731.25" y="4248.75"/> <port id="pr_2ed9d80e-fd93-431a-b86c-bd4a9fcfc8e8_p1" x="7751.25" y="4253.75"/> <port id="pr_2ed9d80e-fd93-431a-b86c-bd4a9fcfc8e8_p2" x="7721.25" y="4253.75"/> </glyph> <glyph class="process" orientation="vertical" 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<glyph class="process" orientation="horizontal" id="pr_6667ee91-b9ee-4b06-85ec-4eaa9fb546af"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15781261 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6433.0" y="5059.0"/> <port id="pr_6667ee91-b9ee-4b06-85ec-4eaa9fb546af_p1" x="6453.0" y="5064.0"/> <port id="pr_6667ee91-b9ee-4b06-85ec-4eaa9fb546af_p2" x="6423.0" y="5064.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_18d26590-2e8d-4d29-af89-5864150b4291"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14765125 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6505.5" y="4971.5"/> <port id="pr_18d26590-2e8d-4d29-af89-5864150b4291_p1" x="6510.5" y="4991.5"/> <port id="pr_18d26590-2e8d-4d29-af89-5864150b4291_p2" x="6510.5" y="4961.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_21e998e7-de7a-413d-9fd1-cdac9a9ef7a2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11583623 PMID:12835328 PMID:12815069 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7044.5" y="3195.0"/> <port id="pr_21e998e7-de7a-413d-9fd1-cdac9a9ef7a2_p1" x="7064.5" y="3200.0"/> <port id="pr_21e998e7-de7a-413d-9fd1-cdac9a9ef7a2_p2" x="7034.5" y="3200.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ef30a024-3fd7-415a-b691-4d4c1f666fc1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11175744 in vitro, Y2H in vitro, GST pulldown in transfected Hela cells, coIP in Hela cells expressing fluorescent proein fusions, XAF1 is nuclear and its co-expression with XIAP induces XIAP nuclear retention in vitro, XIAP mediated inhibition of CASP3 activity is blocked by XAF1 in HEL-299 human embryonic lung cells, XAF1 expression reverts the protective effect of XIAP expression toward serum deprivation-induced cell death References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4966.2554" y="7174.5"/> <port id="pr_ef30a024-3fd7-415a-b691-4d4c1f666fc1_p1" x="4971.2554" y="7164.5"/> <port id="pr_ef30a024-3fd7-415a-b691-4d4c1f666fc1_p2" x="4971.2554" y="7194.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_00db7a6e-c689-42e8-b520-d9e483b82416"> <bbox w="10.0" h="10.0" x="3584.5" y="7690.5"/> <port id="pr_00db7a6e-c689-42e8-b520-d9e483b82416_p1" x="3574.5" y="7695.5"/> <port id="pr_00db7a6e-c689-42e8-b520-d9e483b82416_p2" x="3604.5" y="7695.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5e117cbf-9e4d-4def-8458-7ded4318a6ac"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12773388 in vitro survivin_BIRC5 alone does not suppress CASP3/7/9 activities in HepG2, interaction by coIP of endogenous proteins in HEK293 or in vitro, preferential binding to T34 phosphorylated BIRC5, as determined through the use of unphosphorylatable or phosphomimetic mutants in Hela expression of a dominant negative CDC2 decreases interaction References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7565.0" y="3598.0"/> <port id="pr_5e117cbf-9e4d-4def-8458-7ded4318a6ac_p1" x="7570.0" y="3618.0"/> <port id="pr_5e117cbf-9e4d-4def-8458-7ded4318a6ac_p2" x="7570.0" y="3588.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b946dc94-6a52-4803-9332-7eae13a1ab9d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11069302 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7645.0" y="3705.0"/> <port id="pr_b946dc94-6a52-4803-9332-7eae13a1ab9d_p1" x="7665.0" y="3710.0"/> <port id="pr_b946dc94-6a52-4803-9332-7eae13a1ab9d_p2" x="7635.0" y="3710.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3f22abd0-9499-406d-85f1-f7a2ca7eaebb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15029247 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5467.5" y="3827.1206"/> <port id="pr_3f22abd0-9499-406d-85f1-f7a2ca7eaebb_p1" x="5457.5" y="3832.1206"/> <port id="pr_3f22abd0-9499-406d-85f1-f7a2ca7eaebb_p2" x="5487.5" y="3832.1206"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a206b898-0728-4964-bdf7-c96074e3856a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15199070 ARF binds to and inhibits MYC, in a p53 independent manner. ARF induces MYC localization to nucleolus References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6662.0" y="8017.4053"/> <port id="pr_a206b898-0728-4964-bdf7-c96074e3856a_p1" x="6652.0" y="8022.4053"/> <port id="pr_a206b898-0728-4964-bdf7-c96074e3856a_p2" x="6682.0" y="8022.4053"/> </glyph> <glyph class="process" orientation="vertical" id="pr_625270c6-53aa-482c-ace2-3015b8ffcb75"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6937.5" y="7555.0"/> <port id="pr_625270c6-53aa-482c-ace2-3015b8ffcb75_p1" x="6942.5" y="7575.0"/> <port id="pr_625270c6-53aa-482c-ace2-3015b8ffcb75_p2" x="6942.5" y="7545.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4b3fe086-59e5-4b11-b3b6-c942bec01654"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15029247 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7175.0" y="3322.0"/> <port id="pr_4b3fe086-59e5-4b11-b3b6-c942bec01654_p1" x="7180.0" y="3312.0"/> <port id="pr_4b3fe086-59e5-4b11-b3b6-c942bec01654_p2" x="7180.0" y="3342.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f28e4ded-15d0-41c4-8760-d7145f974033"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12865429 in HEK293 expressing full length GSPT1-FLAG, 10 to 20% of the protein is cleaved in HEK293, mass spectrometry identification of GSPT1 cleaved at position 70 after purification of BIR3 domain binding proteins References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7435.0" y="3215.0"/> <port id="pr_f28e4ded-15d0-41c4-8760-d7145f974033_p1" x="7455.0" y="3220.0"/> <port id="pr_f28e4ded-15d0-41c4-8760-d7145f974033_p2" x="7425.0" y="3220.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_05a98d27-8c04-425b-9bb6-43358366b652"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12865429 cleaved GSPT1 harbors a IAP binding motif at tis C-terminal, AKPF, related to those found in DIABLO or HTRA2 in vitro, cleaved GSPT1 and XIAP interact in HEK293, interaction between endogenous proteins in HEK293 cytoplasmic extract (S100 fraction), cleaved GSPT1 increases CYCS+ATP induced cleavage of CASP3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7344.532" y="3100.5698"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7020.0" y="4745.5"/> <port id="pr_f9908149-6c96-440c-81ed-f7dcd2109d28_p1" x="7025.0" y="4735.5"/> <port id="pr_f9908149-6c96-440c-81ed-f7dcd2109d28_p2" x="7025.0" y="4765.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b1b4ed79-92a1-4957-9dc8-b8995d24f177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7310.0" y="4385.0"/> <port id="pr_b1b4ed79-92a1-4957-9dc8-b8995d24f177_p1" x="7315.0" y="4375.0"/> <port id="pr_b1b4ed79-92a1-4957-9dc8-b8995d24f177_p2" x="7315.0" y="4405.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1b72f9df-f74d-49d7-8a30-2dbe038e2d6b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7110.0" y="4745.0"/> <port id="pr_1b72f9df-f74d-49d7-8a30-2dbe038e2d6b_p1" x="7115.0" y="4735.0"/> <port id="pr_1b72f9df-f74d-49d7-8a30-2dbe038e2d6b_p2" x="7115.0" y="4765.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_05e6a32c-b099-4de6-b584-5142b2a06539"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11896143 in mouse primary neurons, expression of NAIP protects from camptothecin induced cell death in Hela, expression of NAIP protects from etoposide-induced cell death in vitro, with reconbinant proteins, NAIP inhibits CASP3 activity References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7362.0" y="4535.0"/> <port id="pr_05e6a32c-b099-4de6-b584-5142b2a06539_p1" x="7352.0" y="4540.0"/> <port id="pr_05e6a32c-b099-4de6-b584-5142b2a06539_p2" x="7382.0" y="4540.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7de55c7e-db34-4d9f-a736-d0715ba092fe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11896143 in mouse primary neurons, expression of NAIP protects from camptothecin induced cell death in Hela, expression of NAIP protects from etoposide-induced cell death in vitro, with reconbinant proteins, NAIP inhibits CASP7 activity References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7647.0" y="4594.667"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP reactionType:casp.cleavage PMID:9092486 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4857.5" y="8003.0"/> <port id="pr_301e2950-787a-4e4c-96d9-f98198874700_p1" x="4847.5" y="8008.0"/> <port id="pr_301e2950-787a-4e4c-96d9-f98198874700_p2" x="4877.5" y="8008.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_30b815ca-e2b7-4f0b-8404-a3ecdc06a759"> <bbox w="10.0" h="10.0" x="6112.0" y="6084.0"/> <port id="pr_30b815ca-e2b7-4f0b-8404-a3ecdc06a759_p1" x="6117.0" y="6074.0"/> <port id="pr_30b815ca-e2b7-4f0b-8404-a3ecdc06a759_p2" x="6117.0" y="6104.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0fe81140-e994-463a-889a-60daafac9d5a"> <bbox w="10.0" h="10.0" x="5956.25" y="6317.5"/> <port id="pr_0fe81140-e994-463a-889a-60daafac9d5a_p1" x="5961.25" y="6307.5"/> <port id="pr_0fe81140-e994-463a-889a-60daafac9d5a_p2" x="5961.25" y="6337.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ff688b42-b512-4c1d-ab4a-c7514287e6b4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: hierarchical:post-MOMP reactionType:casp.cleavage PMID:9108473 purification of DFFA:DFFB activity from Hela cells cytosol in vitro, CASP3 mediated of DFFA necessary for nucleosomal DNA fragmentation in U937 monocyte cells, in Hela cells, in SV589 human fibroblasts, upon staurosporin, DFFA cleaved into the same fragments as in vitro PMID:9422506 purification and cloning of ICAD:CAD (mouse homologs) from mouse T-cell lymphoma cytosol CASP3-mediated cleavage of ICAD releases CAD, leading to activation of its enzymatic activity and its nuclear localization References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="985.0" y="6709.0"/> <port 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11788820 by HIP1:IFT57 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7380.0" y="4105.0"/> <port id="pr_13bfef9d-e575-4e58-988b-70f9d640009e_p1" x="7370.0" y="4110.0"/> <port id="pr_13bfef9d-e575-4e58-988b-70f9d640009e_p2" x="7400.0" y="4110.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bfd1e6af-1024-4bb4-8e78-8be9e6077c5a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8978814 PMID:8900201 PMID:8663580 PMID:8710882 PMID:11058599 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5661.5" y="7929.75"/> <port id="pr_bfd1e6af-1024-4bb4-8e78-8be9e6077c5a_p1" x="5651.5" y="7934.75"/> <port id="pr_bfd1e6af-1024-4bb4-8e78-8be9e6077c5a_p2" x="5681.5" 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id="pr_b5a4d241-a1a5-4713-ac33-4d1a56e1dc44"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12389032 in IMR90 and MEFs, active E2F1 induces CASP9 transcription References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4983.467" y="7201.25"/> <port id="pr_b5a4d241-a1a5-4713-ac33-4d1a56e1dc44_p1" x="4988.467" y="7221.25"/> <port id="pr_b5a4d241-a1a5-4713-ac33-4d1a56e1dc44_p2" x="4988.467" y="7191.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_48ca8299-9a2c-4c81-b883-d00b1a74b57f"> <bbox w="10.0" h="10.0" x="6091.773" y="5707.034"/> <port id="pr_48ca8299-9a2c-4c81-b883-d00b1a74b57f_p1" x="6096.773" y="5727.034"/> <port id="pr_48ca8299-9a2c-4c81-b883-d00b1a74b57f_p2" x="6096.773" y="5697.034"/> </glyph> <glyph class="process" orientation="horizontal" 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11788820 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7460.0" y="3948.0"/> <port id="pr_373d34eb-6384-474d-a940-c732ced086b2_p1" x="7480.0" y="3953.0"/> <port id="pr_373d34eb-6384-474d-a940-c732ced086b2_p2" x="7450.0" y="3953.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f88f1f3c-6690-4cac-9e0a-59dc527bdc1f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12665579 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7075.0" y="5025.0"/> <port id="pr_f88f1f3c-6690-4cac-9e0a-59dc527bdc1f_p1" x="7080.0" y="5015.0"/> <port 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<title/> </head> <body>References_begin: PMID:11031250 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6937.5" y="7743.0"/> <port id="pr_b0ff0b1d-4aa9-438a-a78f-9ebcbc3ffe74_p1" x="6942.5" y="7763.0"/> <port id="pr_b0ff0b1d-4aa9-438a-a78f-9ebcbc3ffe74_p2" x="6942.5" y="7733.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dcfdaa79-b33d-4dbd-aa8d-e91b2e24e962"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11031250 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6781.1875" y="7582.0"/> <port id="pr_dcfdaa79-b33d-4dbd-aa8d-e91b2e24e962_p1" x="6786.1875" y="7602.0"/> <port id="pr_dcfdaa79-b33d-4dbd-aa8d-e91b2e24e962_p2" x="6786.1875" y="7572.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_63701862-6669-4d95-b08f-817ec045b443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15665297 in Hela, cIAP1 is a nuclear protein, that partially translocates to the cytoplasm upon apoptotic stimuli (UV, staurosporin, TRAIL, TNF+CHX), and in a capase-dependent manner References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6098.877" y="4001.374"/> <port id="pr_63701862-6669-4d95-b08f-817ec045b443_p1" x="6103.877" y="4021.374"/> <port id="pr_63701862-6669-4d95-b08f-817ec045b443_p2" x="6103.877" y="3991.374"/> </glyph> <glyph class="process" orientation="vertical" id="pr_55881e66-67ec-4a87-828b-a432c3b69c65"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a 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id="pr_9e98f436-dd72-4ab4-8de1-c658b3f6723f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12176997 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8239.54" y="1813.4775"/> <port id="pr_9e98f436-dd72-4ab4-8de1-c658b3f6723f_p1" x="8244.54" y="1803.4775"/> <port id="pr_9e98f436-dd72-4ab4-8de1-c658b3f6723f_p2" x="8244.54" y="1833.4775"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8a0abc4b-320d-45c3-a96c-1ec4a4736cf9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15775970 AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction PMID:15590628 calpain 1 mediated processing PMID:15933737 cathepsins and calpain 1 PMID:11278689 flavin not necessary for apoptotic function References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2635.849" y="4254.9966"/> <port id="pr_8a0abc4b-320d-45c3-a96c-1ec4a4736cf9_p1" x="2625.849" y="4259.9966"/> <port id="pr_8a0abc4b-320d-45c3-a96c-1ec4a4736cf9_p2" x="2655.849" y="4259.9966"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_7268d3db-0891-4721-ab8f-b199e0f347b5"> <bbox w="20.0" h="20.0" x="612.5772" y="4124.142"/> <port id="logicglyph_7268d3db-0891-4721-ab8f-b199e0f347b5_p1" x="602.5772" y="4134.142"/> <port id="logicglyph_7268d3db-0891-4721-ab8f-b199e0f347b5_p2" x="642.5772" y="4134.142"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_df8c86d9-c5ed-4119-ab37-317360700092"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17116881 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3686.25" y="5207.5"/> <port id="pr_df8c86d9-c5ed-4119-ab37-317360700092_p1" x="3706.25" y="5212.5"/> <port id="pr_df8c86d9-c5ed-4119-ab37-317360700092_p2" x="3676.25" y="5212.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a60f9562-f3a7-4733-9c7c-4a18a0e902b1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5718.855" y="5582.749"/> <port id="pr_a60f9562-f3a7-4733-9c7c-4a18a0e902b1_p1" x="5738.855" y="5587.749"/> <port id="pr_a60f9562-f3a7-4733-9c7c-4a18a0e902b1_p2" x="5708.855" y="5587.749"/> </glyph> <glyph class="process" orientation="vertical" 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orientation="horizontal" id="pr_fa4af869-582b-4f53-a32c-4fc0a55dfcec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10929711 identification of DIABLO as an inhibitor of XIAP PMID:11140637 structure of XIAP BIR3 complexed to a peptide from DIABLO PMID:15078891 DIABLO inhibits XIAP ubiquitin-ligase activity References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7312.0" y="3335.0"/> <port id="pr_fa4af869-582b-4f53-a32c-4fc0a55dfcec_p1" x="7302.0" y="3340.0"/> <port id="pr_fa4af869-582b-4f53-a32c-4fc0a55dfcec_p2" x="7332.0" y="3340.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_de356f15-32d4-4706-964c-3d9e94657657"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12660240 in Hela, upon taxol treatment, interaction detected by GST pull-down, BIRC5 antagonizes DIABLO pro-apoptotic effect References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7425.0" y="3673.0"/> <port id="pr_de356f15-32d4-4706-964c-3d9e94657657_p1" x="7430.0" y="3693.0"/> <port id="pr_de356f15-32d4-4706-964c-3d9e94657657_p2" x="7430.0" y="3663.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cfa0e0d8-8fd8-41a5-95eb-a10e3ffbd98c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11801603 in 293T, interaction between ectopically expressed proteins in vitro, interaction between a DIABLO peptide and the BIR domain of ML-IAP in 293T, binding of DIABLO to BIRC7 antagonizes the binding of processed CASP9 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7285.0" y="3673.0"/> <port id="pr_cfa0e0d8-8fd8-41a5-95eb-a10e3ffbd98c_p1" x="7290.0" y="3693.0"/> <port id="pr_cfa0e0d8-8fd8-41a5-95eb-a10e3ffbd98c_p2" x="7290.0" y="3663.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e25568a1-eefb-450b-aaf2-522c11a51f4e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11801603 in 293T, interaction of overexpressed proteins, by coIP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7095.7188" y="5515.0"/> <port id="pr_e25568a1-eefb-450b-aaf2-522c11a51f4e_p1" x="7085.7188" y="5520.0"/> <port id="pr_e25568a1-eefb-450b-aaf2-522c11a51f4e_p2" x="7115.7188" y="5520.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_96d5dbeb-d509-44d6-b1ce-8f5246484e38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11157976 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7210.9375" y="5415.0"/> <port id="pr_96d5dbeb-d509-44d6-b1ce-8f5246484e38_p1" x="7200.9375" y="5420.0"/> <port id="pr_96d5dbeb-d509-44d6-b1ce-8f5246484e38_p2" x="7230.9375" y="5420.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9eb4914b-5739-4ecd-a830-187dea34e88c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:1457818 cloning of the human oxoglutarate-malate transporter References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="997.53613" y="3923.0085"/> <port id="pr_9eb4914b-5739-4ecd-a830-187dea34e88c_p1" 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</head> <body>References_begin: PMID:11243884 by SLC38A5 and SLC38A3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="514.375" y="3349.0"/> <port id="pr_b304f831-735b-410d-81be-6f6cca01b404_p1" x="504.375" y="3354.0"/> <port id="pr_b304f831-735b-410d-81be-6f6cca01b404_p2" x="534.375" y="3354.0"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_5020b5da-61b4-4fed-a3e6-f65050bd2039"> <bbox w="20.0" h="20.0" x="268.97443" y="3238.62"/> <port id="logicglyph_5020b5da-61b4-4fed-a3e6-f65050bd2039_p1" x="258.97443" y="3248.62"/> <port id="logicglyph_5020b5da-61b4-4fed-a3e6-f65050bd2039_p2" x="298.97443" y="3248.62"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c7aa1d9e-648e-4c35-ad4c-6159d2272bcc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19033189 in human glioma SF188 cells, which display MYC deregulation, shRNA against MYC represses SLC38A5 expression, as assessed by qPCR, and MYC is recruited to SLC38A5 promoter, as assessed by ChIP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7156.491" y="7220.3994"/> <port id="pr_c7aa1d9e-648e-4c35-ad4c-6159d2272bcc_p1" x="7161.491" y="7240.3994"/> <port id="pr_c7aa1d9e-648e-4c35-ad4c-6159d2272bcc_p2" x="7161.491" y="7210.3994"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b86a2c6e-4057-414d-b100-f05c155d4ab9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19033189 in human glioma SF188 cells, which display MYC deregulation, shRNA against MYC represses SLC1A5 expression, as assessed by qPCR, and MYC is recruited to SLC1A5 promoter, as assessed by ChIP in MEFs expressing a MYC-ER fusion, upon 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y="6830.7935"/> <port id="logicglyph_a65551cc-63e7-4adc-b756-5b01b5200274_p2" x="7126.3486" y="6830.7935"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0f961f46-49ff-40c7-82bb-b00197e3a835"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19219026 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7187.25" y="6941.0"/> <port id="pr_0f961f46-49ff-40c7-82bb-b00197e3a835_p1" x="7192.25" y="6961.0"/> <port id="pr_0f961f46-49ff-40c7-82bb-b00197e3a835_p2" x="7192.25" y="6931.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8b819203-5b6f-46c8-98d3-91d614ece380"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> 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orientation="horizontal" id="pr_cb9f6206-91ea-45e0-b776-8c56b88593ad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16839620 review heme biosynthesis in mammals References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="668.1831" y="4119.6826"/> <port id="pr_cb9f6206-91ea-45e0-b776-8c56b88593ad_p1" x="658.1831" y="4124.6826"/> <port id="pr_cb9f6206-91ea-45e0-b776-8c56b88593ad_p2" x="688.1831" y="4124.6826"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b8d1b634-24eb-4d9b-8a19-21475b3bf57f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10561552 caracterization of human ferrochelatase as a Fe-S homodimer 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</head> <body>References_begin: PMID:16115609 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10291.277" y="1461.6345"/> <port id="pr_0d30f421-edc7-4ba2-8658-978ae9290960_p1" x="10296.277" y="1451.6345"/> <port id="pr_0d30f421-edc7-4ba2-8658-978ae9290960_p2" x="10296.277" y="1481.6345"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_060567ac-e9d7-406b-9ef1-8868001b2fcf"> <bbox w="10.0" h="10.0" x="6787.4863" y="2829.4194"/> <port id="pr_060567ac-e9d7-406b-9ef1-8868001b2fcf_p1" x="6777.4863" y="2834.4194"/> <port id="pr_060567ac-e9d7-406b-9ef1-8868001b2fcf_p2" x="6807.4863" y="2834.4194"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ce26c3bd-b085-474a-bd46-acdf9ff2ac99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10874044 in MCF7 by NFE2L2, upon cadmium exposure PMID:10821856 in mouse primary peritoneal macrophages, by NFE2L2 PMID:12356737 by BACH1 PMID:12511571 in A549 by BACH1 upon hypoxia References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8005.0" y="7135.0"/> <port id="pr_ce26c3bd-b085-474a-bd46-acdf9ff2ac99_p1" x="8010.0" y="7155.0"/> <port id="pr_ce26c3bd-b085-474a-bd46-acdf9ff2ac99_p2" x="8010.0" y="7125.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f95d3231-0df2-49d3-994c-3e99ccb77658"> <bbox w="10.0" h="10.0" x="9103.529" y="4273.75"/> <port id="pr_f95d3231-0df2-49d3-994c-3e99ccb77658_p1" x="9108.529" y="4293.75"/> <port id="pr_f95d3231-0df2-49d3-994c-3e99ccb77658_p2" x="9108.529" y="4263.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c8a34693-9119-466e-92b0-8c2a8c2c8c0e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10821856 in mouse primary peritoneal macrophages, by NFE2L2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7349.4434" y="7207.8994"/> <port id="pr_c8a34693-9119-466e-92b0-8c2a8c2c8c0e_p1" x="7339.4434" y="7212.8994"/> <port id="pr_c8a34693-9119-466e-92b0-8c2a8c2c8c0e_p2" x="7369.4434" y="7212.8994"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c98edc0b-44ab-4d7c-b4c5-2f63684fadc7"> <bbox w="10.0" h="10.0" x="9586.182" y="4341.25"/> <port id="pr_c98edc0b-44ab-4d7c-b4c5-2f63684fadc7_p1" x="9591.182" y="4361.25"/> <port id="pr_c98edc0b-44ab-4d7c-b4c5-2f63684fadc7_p2" x="9591.182" y="4331.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_81108c34-1ea0-4165-bfdb-7bec571e35ab"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: 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y="2828.9998"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_986a127b-7664-4ae2-b230-299dcd37b7f3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16915281 in mouse, PML directs mTOR to the nucleus, thereby inhibiting its interaction with Rheb and its ability to promote HIF1A translation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2728.75" y="7833.75"/> <port id="pr_986a127b-7664-4ae2-b230-299dcd37b7f3_p1" x="2748.75" y="7838.75"/> <port id="pr_986a127b-7664-4ae2-b230-299dcd37b7f3_p2" x="2718.75" y="7838.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5a5b3664-dabe-4bca-bb4f-47df7b0991b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:8882641 access only to abstract References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2963.6946" y="7226.375"/> <port id="pr_5a5b3664-dabe-4bca-bb4f-47df7b0991b2_p1" x="2968.6946" y="7246.375"/> <port id="pr_5a5b3664-dabe-4bca-bb4f-47df7b0991b2_p2" x="2968.6946" y="7216.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_347a0c58-d115-4f6e-90c1-33e829be46fe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12011429 in human 2091 primary fibroblasts References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7338.091" y="7237.8994"/> <port id="pr_347a0c58-d115-4f6e-90c1-33e829be46fe_p1" x="7343.091" y="7257.8994"/> <port id="pr_347a0c58-d115-4f6e-90c1-33e829be46fe_p2" x="7343.091" y="7227.8994"/> </glyph> <glyph class="process" 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id="pr_ffb81604-f4f6-49b9-a90c-b46cac40c351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18046414 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2718.7124" y="7207.125"/> <port id="pr_ffb81604-f4f6-49b9-a90c-b46cac40c351_p1" x="2723.7124" y="7227.125"/> <port id="pr_ffb81604-f4f6-49b9-a90c-b46cac40c351_p2" x="2723.7124" y="7197.125"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c57f2b49-0c39-4860-a579-3527a6095dff"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18046414 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2647.5" y="7214.75"/> <port 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x="1924.25" y="7014.6436"/> </glyph> <glyph class="process" orientation="vertical" id="pr_216b0188-1fb5-4f75-946f-001db11d40b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16864783 in MEFs in MCF7 HEK293T References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1967.5" y="7730.0"/> <port id="pr_216b0188-1fb5-4f75-946f-001db11d40b2_p1" x="1972.5" y="7720.0"/> <port id="pr_216b0188-1fb5-4f75-946f-001db11d40b2_p2" x="1972.5" y="7750.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6380da4a-f881-4977-acb3-2ef073bd49e6"> <bbox w="10.0" h="10.0" x="2039.25" y="7630.0"/> <port id="pr_6380da4a-f881-4977-acb3-2ef073bd49e6_p1" x="2029.25" y="7635.0"/> <port id="pr_6380da4a-f881-4977-acb3-2ef073bd49e6_p2" x="2059.25" y="7635.0"/> </glyph> <glyph class="process" orientation="horizontal" 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15004004 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1848.7507" y="7214.25"/> <port id="pr_9783c1c1-6da3-488f-9276-673f50495198_p1" x="1853.7507" y="7234.25"/> <port id="pr_9783c1c1-6da3-488f-9276-673f50495198_p2" x="1853.7507" y="7204.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b8118b0b-4744-4f95-a7c5-6d043d596419"> <bbox w="10.0" h="10.0" x="1845.4192" y="6604.25"/> <port id="pr_b8118b0b-4744-4f95-a7c5-6d043d596419_p1" x="1850.4192" y="6624.25"/> <port id="pr_b8118b0b-4744-4f95-a7c5-6d043d596419_p2" x="1850.4192" y="6594.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f072c5b3-7927-49b6-b8f9-9abf09d44d62"> <bbox w="10.0" h="10.0" x="1430.1201" y="4869.094"/> <port id="pr_f072c5b3-7927-49b6-b8f9-9abf09d44d62_p1" x="1435.1201" y="4859.094"/> <port id="pr_f072c5b3-7927-49b6-b8f9-9abf09d44d62_p2" x="1435.1201" y="4889.094"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f683e254-012a-4111-bd97-16ff52ffcb7d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11410595 ATPAF1 role in assembly of mitochondrial ATP synthase inferred from yeast, on the basis that ATPAF1 interacts with ATP5B (Y2H) and complements the yeast mutant similar function suggested for ATPAF2 PMID:14701807 in vitro, human ATPAF2 functions as a protein chaperone PMID:14757859 a mutation found in gene ATPAF2 from a patient with mitochondrial encephalomyopathies supports the role of ATPAF2 as an ATPase assembly gene PMID:18953340 TMEM70 is involved in mitochondrial ATP synthase biogenesis 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y="4888.5"/> <port id="pr_3c388273-9a8c-4780-9729-eba702f99f7d_p1" x="3454.2834" y="4908.5"/> <port id="pr_3c388273-9a8c-4780-9729-eba702f99f7d_p2" x="3454.2834" y="4878.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_24471ffa-81ea-4a6c-be13-c94786b0fe4d"> <bbox w="10.0" h="10.0" x="3535.75" y="4875.0"/> <port id="pr_24471ffa-81ea-4a6c-be13-c94786b0fe4d_p1" x="3540.75" y="4865.0"/> <port id="pr_24471ffa-81ea-4a6c-be13-c94786b0fe4d_p2" x="3540.75" y="4895.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c3539b14-5043-4cdb-b600-c1ad0a989df1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: from unipathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1385.3218" y="3929.6057"/> <port id="pr_c3539b14-5043-4cdb-b600-c1ad0a989df1_p1" x="1405.3218" y="3934.6057"/> 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<notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12743597 in 786-O human carcinoma cell line References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5984.0117" y="7194.3994"/> <port id="pr_d513f227-d82a-4b0f-8ebc-4893a891191c_p1" x="5989.0117" y="7214.3994"/> <port id="pr_d513f227-d82a-4b0f-8ebc-4893a891191c_p2" x="5989.0117" y="7184.3994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_22096068-ccf9-4d7c-9733-a3b58e5d622b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9603954 rapamycin-induced inhibition of CCND1 translation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4128.0" y="7398.619"/> <port id="pr_22096068-ccf9-4d7c-9733-a3b58e5d622b_p1" x="4148.0" y="7403.619"/> <port id="pr_22096068-ccf9-4d7c-9733-a3b58e5d622b_p2" x="4118.0" y="7403.619"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4853dbbb-c920-4992-ad62-5dc3a1c20d79"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9316.8125" y="2726.001"/> <port id="pr_4853dbbb-c920-4992-ad62-5dc3a1c20d79_p1" x="9306.8125" y="2731.001"/> <port id="pr_4853dbbb-c920-4992-ad62-5dc3a1c20d79_p2" x="9336.8125" y="2731.001"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f2fb651c-77d3-4b66-87ce-06e331215f0c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9328.25" y="2783.4084"/> <port id="pr_f2fb651c-77d3-4b66-87ce-06e331215f0c_p1" x="9318.25" y="2788.4084"/> <port id="pr_f2fb651c-77d3-4b66-87ce-06e331215f0c_p2" x="9348.25" y="2788.4084"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4ab0b5b5-7859-453f-b756-4b1476b25194"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17991864 FKBP8 antagonizes mTORC1, and mediates RHEB induced mTORC1 activation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9223.867" y="2847.75"/> <port id="pr_4ab0b5b5-7859-453f-b756-4b1476b25194_p1" x="9228.867" y="2867.75"/> <port 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in HEK293, co-precipitation of ectopically expressed tagged proteins in HeLa cells infected with G0S2-HA Ad virus, co-precipitation of endogenous BCL2 with HA antibody in HCT116 (transient transfection), interaction detected by FRET Competition between G0S2 and BAX for binding to BCL2 in HEK293, co-IP experiments with tagged protein shows that G0S2 competes with BAX for binding to BCL2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5215.5" y="5011.7"/> <port id="pr_b8ff3ed5-02db-4682-8ac5-f7f62aeef141_p1" x="5235.5" y="5016.7"/> <port id="pr_b8ff3ed5-02db-4682-8ac5-f7f62aeef141_p2" x="5205.5" y="5016.7"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ef9c3114-8eda-4811-961c-2674b97589d0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9660918 References_end </body> </html> 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id="pr_4d603c8c-b089-4521-a8d9-219beb98e4ce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11909699 in HepG2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7510.555" y="7202.8994"/> <port id="pr_4d603c8c-b089-4521-a8d9-219beb98e4ce_p1" x="7500.555" y="7207.8994"/> <port id="pr_4d603c8c-b089-4521-a8d9-219beb98e4ce_p2" x="7530.555" y="7207.8994"/> </glyph> <glyph class="process" orientation="vertical" id="pr_754289f5-f7f3-47f9-a9c6-32a60aaa6e7c"> <bbox w="10.0" h="10.0" x="8096.8945" y="3817.75"/> <port id="pr_754289f5-f7f3-47f9-a9c6-32a60aaa6e7c_p1" x="8101.8945" y="3837.75"/> <port id="pr_754289f5-f7f3-47f9-a9c6-32a60aaa6e7c_p2" x="8101.8945" y="3807.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ae1b4155-a512-4208-8b5e-1c2e87579650"> <notes> <html 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<head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9395.0" y="527.5"/> <port id="pr_5874e2bd-4a90-47f7-8acb-5003cf0a62b7_p1" x="9400.0" y="517.5"/> <port id="pr_5874e2bd-4a90-47f7-8acb-5003cf0a62b7_p2" x="9400.0" y="547.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_53ef6781-c6e4-46c4-b31c-ebb0e61b5c81"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9350.0" y="527.5"/> <port id="pr_53ef6781-c6e4-46c4-b31c-ebb0e61b5c81_p1" x="9355.0" y="517.5"/> <port id="pr_53ef6781-c6e4-46c4-b31c-ebb0e61b5c81_p2" x="9355.0" y="547.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_53928905-235c-4e7d-99a5-3781f0b11341"> <bbox w="10.0" h="10.0" x="4936.125" y="6996.821"/> <port id="pr_53928905-235c-4e7d-99a5-3781f0b11341_p1" x="4956.125" y="7001.821"/> <port id="pr_53928905-235c-4e7d-99a5-3781f0b11341_p2" x="4926.125" y="7001.821"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_53e71969-2ce4-4d22-9714-7f3482ea9c1c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10213689 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7093.9746" y="4315.784"/> <port id="pr_53e71969-2ce4-4d22-9714-7f3482ea9c1c_p1" x="7113.9746" y="4320.784"/> <port id="pr_53e71969-2ce4-4d22-9714-7f3482ea9c1c_p2" x="7083.9746" y="4320.784"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1404b115-4ccb-440c-9a70-25dbb1b58789"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation. 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<body>References_begin: PMID:15229189 SCO1, SCO2, and COX17 act cooperatively to load MT-CO2 with copper (copper chaperones) PMID:19393246 in Hela, COX17 siRNA interferes with copper loading into MT-CO2 PMID:18458339 detailed description of COX17 mediated copper loading of SCO proteins, and interactions with the disulfide based modifications of these proteins References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2418.25" y="5116.5"/> <port id="pr_36b28f63-3f91-43db-a9af-b4c87deead37_p1" x="2438.25" y="5121.5"/> <port id="pr_36b28f63-3f91-43db-a9af-b4c87deead37_p2" x="2408.25" y="5121.5"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_0b009d84-36b0-4d54-9ac3-a6b3c81ad11e"> <bbox w="20.0" h="20.0" x="2416.138" y="5081.5107"/> <port id="logicglyph_0b009d84-36b0-4d54-9ac3-a6b3c81ad11e_p1" x="2426.138" y="5071.5107"/> <port id="logicglyph_0b009d84-36b0-4d54-9ac3-a6b3c81ad11e_p2" x="2426.138" y="5111.5107"/> </glyph> <glyph class="process" orientation="vertical" id="pr_77b0fcda-6e48-49df-9c61-2145fca0e93a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14966295 in NIH3T3 by FOXO3 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4431.7236" y="7230.299"/> <port id="pr_77b0fcda-6e48-49df-9c61-2145fca0e93a_p1" x="4436.7236" y="7250.299"/> <port id="pr_77b0fcda-6e48-49df-9c61-2145fca0e93a_p2" x="4436.7236" y="7220.299"/> </glyph> <glyph class="process" orientation="vertical" id="pr_86f5c3fc-3d97-450a-a1de-18cc78d7b0a2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4625.0" y="7510.0"/> <port id="pr_86f5c3fc-3d97-450a-a1de-18cc78d7b0a2_p1" x="4630.0" y="7500.0"/> <port id="pr_86f5c3fc-3d97-450a-a1de-18cc78d7b0a2_p2" x="4630.0" y="7530.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1c28114a-f2e4-4e87-9309-52b8e62430fa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4650.0" y="7510.0"/> <port id="pr_1c28114a-f2e4-4e87-9309-52b8e62430fa_p1" x="4655.0" y="7530.0"/> <port id="pr_1c28114a-f2e4-4e87-9309-52b8e62430fa_p2" x="4655.0" y="7500.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4d02078f-2b10-4d2f-9980-f492233e1080"> <bbox w="10.0" h="10.0" x="4454.4316" y="7316.299"/> <port id="pr_4d02078f-2b10-4d2f-9980-f492233e1080_p1" x="4459.4316" y="7306.299"/> <port id="pr_4d02078f-2b10-4d2f-9980-f492233e1080_p2" x="4459.4316" y="7336.299"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cd930a6e-dc5e-4d1e-a817-61881add35a3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19834492 in different cancer cell lines (CEM, C666-1 and HCT116) that express empty or BCL2 plasmids References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2552.875" y="4207.5"/> <port id="pr_cd930a6e-dc5e-4d1e-a817-61881add35a3_p1" x="2557.875" y="4197.5"/> <port id="pr_cd930a6e-dc5e-4d1e-a817-61881add35a3_p2" x="2557.875" y="4227.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d985d7a0-78fe-43fb-b4d9-a0940f707d28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3939.5" y="6661.5"/> <port id="pr_d985d7a0-78fe-43fb-b4d9-a0940f707d28_p1" x="3944.5" y="6651.5"/> <port id="pr_d985d7a0-78fe-43fb-b4d9-a0940f707d28_p2" x="3944.5" y="6681.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ed04e142-df7a-46ba-9dd5-a02aed7cf165"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3901.5" y="6662.0"/> <port id="pr_ed04e142-df7a-46ba-9dd5-a02aed7cf165_p1" x="3906.5" y="6652.0"/> <port id="pr_ed04e142-df7a-46ba-9dd5-a02aed7cf165_p2" x="3906.5" y="6682.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_073dc8a6-44cf-4675-8c53-ffe7d3b1712a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19960022 in Saos2 human primary osteosarcoma cell line conditionally expressing E2F1, increased expression of MIR449A in U2OS and H1299 MIR449 expression upon transient transfection of E2F1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4354.294" y="7227.25"/> <port id="pr_073dc8a6-44cf-4675-8c53-ffe7d3b1712a_p1" x="4359.294" y="7247.25"/> <port id="pr_073dc8a6-44cf-4675-8c53-ffe7d3b1712a_p2" x="4359.294" y="7217.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5b937ea7-a359-4ada-a3f3-677584a86523"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19960022 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4349.5" y="7017.0"/> <port id="pr_5b937ea7-a359-4ada-a3f3-677584a86523_p1" x="4354.5" y="7037.0"/> <port id="pr_5b937ea7-a359-4ada-a3f3-677584a86523_p2" x="4354.5" y="7007.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_59484051-8464-4b17-81ae-3a42921e11d0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19960022 by MIR34A and MIR449A PMID:18755897 by MIR34A PMID:20185821 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2225.9546" y="6606.495"/> <port id="pr_59484051-8464-4b17-81ae-3a42921e11d0_p1" x="2230.9546" y="6626.495"/> <port id="pr_59484051-8464-4b17-81ae-3a42921e11d0_p2" x="2230.9546" y="6596.495"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_6fcc25b6-eb0f-4d3f-b956-a7872373767b"> <bbox w="20.0" h="20.0" x="1127.7072" y="6825.6904"/> <port id="logicglyph_6fcc25b6-eb0f-4d3f-b956-a7872373767b_p1" x="1117.7072" y="6835.6904"/> <port id="logicglyph_6fcc25b6-eb0f-4d3f-b956-a7872373767b_p2" x="1157.7072" y="6835.6904"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_004508a0-777d-4196-a42c-c66c82553ba0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4287.5" y="7550.0"/> <port id="pr_004508a0-777d-4196-a42c-c66c82553ba0_p1" x="4292.5" y="7540.0"/> <port id="pr_004508a0-777d-4196-a42c-c66c82553ba0_p2" x="4292.5" y="7570.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2fa47860-4754-43f0-a3e4-e2eb1384b089"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19960022 by MIR34A and MIR449A References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5876.801" y="6542.7603"/> <port id="pr_2fa47860-4754-43f0-a3e4-e2eb1384b089_p1" x="5866.801" y="6547.7603"/> <port id="pr_2fa47860-4754-43f0-a3e4-e2eb1384b089_p2" x="5896.801" y="6547.7603"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_545397be-7fe8-44f9-ba9b-7b97846e2be0"> <bbox w="20.0" h="20.0" x="3598.245" y="6801.727"/> <port id="logicglyph_545397be-7fe8-44f9-ba9b-7b97846e2be0_p1" x="3588.245" y="6811.727"/> <port id="logicglyph_545397be-7fe8-44f9-ba9b-7b97846e2be0_p2" x="3628.245" y="6811.727"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_9b8f5ec0-8cec-4c9d-a3b3-5274b88163c5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19590512 Siva1 and mdm2 PMID:15989956 HUWE1 PMID:19960022 effect of SIRT1 K382-deacetylation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3590.0" y="7520.0"/> <port id="pr_9b8f5ec0-8cec-4c9d-a3b3-5274b88163c5_p1" x="3580.0" y="7525.0"/> <port id="pr_9b8f5ec0-8cec-4c9d-a3b3-5274b88163c5_p2" x="3610.0" y="7525.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_c646700d-a984-4ddd-930e-6d10827bd24d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23030059 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3620.0" y="7510.0"/> <port id="pr_c646700d-a984-4ddd-930e-6d10827bd24d_p1" x="3640.0" y="7515.0"/> <port id="pr_c646700d-a984-4ddd-930e-6d10827bd24d_p2" x="3610.0" y="7515.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_73bd1f26-d35e-45d9-b18c-72bf317431cf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4247.5" y="7550.0"/> <port id="pr_73bd1f26-d35e-45d9-b18c-72bf317431cf_p1" x="4252.5" y="7570.0"/> <port id="pr_73bd1f26-d35e-45d9-b18c-72bf317431cf_p2" x="4252.5" y="7540.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dac9d54c-5e24-4b18-b823-7b7dad54f442"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12011449 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5387.0" y="5165.0"/> <port id="pr_dac9d54c-5e24-4b18-b823-7b7dad54f442_p1" x="5377.0" y="5170.0"/> <port id="pr_dac9d54c-5e24-4b18-b823-7b7dad54f442_p2" x="5407.0" y="5170.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_678933b0-8085-44f1-9bf3-47d782a3e095"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18593906 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4724.349" y="7725.6934"/> <port id="pr_678933b0-8085-44f1-9bf3-47d782a3e095_p1" x="4729.349" y="7715.6934"/> <port id="pr_678933b0-8085-44f1-9bf3-47d782a3e095_p2" x="4729.349" y="7745.6934"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a06cf32d-776b-4c6b-8015-3991cde4d828"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18593906 in HEK293T with transfected proteins References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5148.0" y="6356.17"/> <port id="pr_a06cf32d-776b-4c6b-8015-3991cde4d828_p1" x="5168.0" y="6361.17"/> <port id="pr_a06cf32d-776b-4c6b-8015-3991cde4d828_p2" x="5138.0" y="6361.17"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1848111b-c412-44a3-9eab-35d778b5389a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17603038 in HLE B3 human lens epithelial cells, TXNIP interacts with TXN and its over-expression decreases TXN disulfide reductase activity PMID:19847012 in HEK293, upon TXNIP ectopic expression, suppression of TXN denitrosylase activity PMID:17976314 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="11303.25" y="1686.5754"/> <port id="pr_1848111b-c412-44a3-9eab-35d778b5389a_p1" x="11323.25" y="1691.5754"/> <port id="pr_1848111b-c412-44a3-9eab-35d778b5389a_p2" x="11293.25" y="1691.5754"/> </glyph> <glyph class="process" orientation="vertical" id="pr_47ae7521-5231-47f9-b142-0aa56c6f33e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20068034 in H1299, ITCH downregulates the expression of TXNIP (siRNA against ITCH, ITCH ectopic expression), ITCH interacts with TXNIP and promotes its ubiquitinylation in vitro, in H1299, reconstitution of the ubiquitin-ligase system References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="11345.0" y="1825.0"/> <port id="pr_47ae7521-5231-47f9-b142-0aa56c6f33e7_p1" x="11350.0" y="1815.0"/> <port id="pr_47ae7521-5231-47f9-b142-0aa56c6f33e7_p2" x="11350.0" y="1845.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8e8267fa-88c4-4bcf-a54d-279a9c22b1b9"> <bbox w="10.0" h="10.0" x="11345.0" y="1927.5"/> <port id="pr_8e8267fa-88c4-4bcf-a54d-279a9c22b1b9_p1" x="11350.0" y="1917.5"/> <port 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4372.0" y="1010.0"/> <port id="pr_bf8ff04f-9858-4d82-b417-b38c4a362ee8_p1" x="4362.0" y="1015.0"/> <port id="pr_bf8ff04f-9858-4d82-b417-b38c4a362ee8_p2" x="4392.0" y="1015.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b63234dd-14f8-41a6-a67f-20993a0f4506"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: logical:re1143_s3865_re1141=FALSE logical:re1143_s3866_re1142=FALSE PMID:16469705 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4305.0" y="980.0"/> <port id="pr_b63234dd-14f8-41a6-a67f-20993a0f4506_p1" x="4310.0" y="970.0"/> <port id="pr_b63234dd-14f8-41a6-a67f-20993a0f4506_p2" x="4310.0" y="1000.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fffbc31b-2961-4409-9b6c-1bfebb29a174"> <notes> <html 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16469705 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4305.0" y="1105.0"/> <port id="pr_f0c925b1-3e1c-43c5-9659-f9c4501bea8f_p1" x="4325.0" y="1110.0"/> <port id="pr_f0c925b1-3e1c-43c5-9659-f9c4501bea8f_p2" x="4295.0" y="1110.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_90aec0c1-13b1-4531-aa5e-6b95840c2f5b"> <bbox w="10.0" h="10.0" x="4225.0" y="1147.5"/> <port id="pr_90aec0c1-13b1-4531-aa5e-6b95840c2f5b_p1" x="4230.0" y="1137.5"/> <port id="pr_90aec0c1-13b1-4531-aa5e-6b95840c2f5b_p2" x="4230.0" y="1167.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4aaea4d8-4a57-4964-adfc-af87770c5ebc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12531547 PMID:11279185 CD95-mediated clustering by ceramide is prerequisite for signaling and death PMID:26801188 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4655.0" y="393.5"/> <port id="pr_4aaea4d8-4a57-4964-adfc-af87770c5ebc_p1" x="4660.0" y="383.5"/> <port id="pr_4aaea4d8-4a57-4964-adfc-af87770c5ebc_p2" x="4660.0" y="413.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2b60ab52-0aa2-422c-b0bf-a93a309246dc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12441346 in murine L929 cell line, RIPK1 is a HSP90 client protein References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5125.0" y="410.0"/> <port id="pr_2b60ab52-0aa2-422c-b0bf-a93a309246dc_p1" x="5130.0" y="400.0"/> <port 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class="process" orientation="vertical" id="pr_dd4bcabc-67a2-4195-9dfb-880c30e9df7c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5447.627" y="406.1239"/> <port id="pr_dd4bcabc-67a2-4195-9dfb-880c30e9df7c_p1" x="5452.627" y="396.1239"/> <port id="pr_dd4bcabc-67a2-4195-9dfb-880c30e9df7c_p2" x="5452.627" y="426.1239"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7f01a5b0-676a-4900-bc3f-2930b643159a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18022362 SMAC mimetic induces cIAP auto-ubiquitinylation and degradation PMID:18022363 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5478.0" y="685.25"/> <port id="pr_7f01a5b0-676a-4900-bc3f-2930b643159a_p1" x="5483.0" y="675.25"/> <port id="pr_7f01a5b0-676a-4900-bc3f-2930b643159a_p2" x="5483.0" y="705.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4266d60c-7dfa-4bdd-91c1-7435d4f2def0"> <bbox w="10.0" h="10.0" x="5478.0" y="782.75"/> <port id="pr_4266d60c-7dfa-4bdd-91c1-7435d4f2def0_p1" x="5483.0" y="772.75"/> <port id="pr_4266d60c-7dfa-4bdd-91c1-7435d4f2def0_p2" x="5483.0" y="802.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_86ba7c8f-7abb-42b2-b90d-1e318e31acb5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8134.5" y="6298.0"/> <port id="pr_86ba7c8f-7abb-42b2-b90d-1e318e31acb5_p1" x="8154.5" y="6303.0"/> <port id="pr_86ba7c8f-7abb-42b2-b90d-1e318e31acb5_p2" x="8124.5" y="6303.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_234c0511-52a6-410d-bf54-847e1cf9f66b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20111001 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7985.875" y="6197.875"/> <port id="pr_234c0511-52a6-410d-bf54-847e1cf9f66b_p1" x="7975.875" y="6202.875"/> <port id="pr_234c0511-52a6-410d-bf54-847e1cf9f66b_p2" x="8005.875" y="6202.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0f26c25d-9b56-41c0-90e2-9147d36493c6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4167.5" y="7760.0"/> <port id="pr_0f26c25d-9b56-41c0-90e2-9147d36493c6_p1" x="4172.5" y="7750.0"/> <port id="pr_0f26c25d-9b56-41c0-90e2-9147d36493c6_p2" x="4172.5" y="7780.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_26df3db1-59ca-4d2f-8703-6e5459cc8659"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4207.5" y="7760.0"/> <port id="pr_26df3db1-59ca-4d2f-8703-6e5459cc8659_p1" x="4212.5" y="7780.0"/> <port id="pr_26df3db1-59ca-4d2f-8703-6e5459cc8659_p2" x="4212.5" y="7750.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9c72ac1c-574c-486b-ad2f-0ed78cf926a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cf. Rb pathway References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4214.625" y="7930.0"/> <port id="pr_9c72ac1c-574c-486b-ad2f-0ed78cf926a4_p1" x="4204.625" y="7935.0"/> <port id="pr_9c72ac1c-574c-486b-ad2f-0ed78cf926a4_p2" x="4234.625" y="7935.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_057598a0-49d4-4ab3-9518-fd169b03d0e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1558.75" y="818.6552"/> <port id="pr_057598a0-49d4-4ab3-9518-fd169b03d0e7_p1" x="1548.75" y="823.6552"/> <port id="pr_057598a0-49d4-4ab3-9518-fd169b03d0e7_p2" x="1578.75" y="823.6552"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1b958742-3e05-47b9-a9ca-9a9cdd99d7ea"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1685.25" y="816.4052"/> <port id="pr_1b958742-3e05-47b9-a9ca-9a9cdd99d7ea_p1" x="1690.25" y="806.4052"/> <port id="pr_1b958742-3e05-47b9-a9ca-9a9cdd99d7ea_p2" x="1690.25" y="836.4052"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_391af298-252f-42d8-b618-89b7550557b1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19448625 in rat cortical neuron primary culture References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1760.25" y="856.4052"/> <port id="pr_391af298-252f-42d8-b618-89b7550557b1_p1" x="1750.25" y="861.4052"/> <port id="pr_391af298-252f-42d8-b618-89b7550557b1_p2" x="1780.25" y="861.4052"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2a4b1e02-d302-40f4-8a1c-de2e37b5bddd"> <bbox w="10.0" h="10.0" x="1916.0" y="854.0"/> <port id="pr_2a4b1e02-d302-40f4-8a1c-de2e37b5bddd_p1" x="1906.0" y="859.0"/> <port id="pr_2a4b1e02-d302-40f4-8a1c-de2e37b5bddd_p2" x="1936.0" y="859.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e05a5dda-e7c1-4f52-aeb6-114255904fa9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20208519 TRIP12 is a E3 ubiquitin ligase for ARF MYC, independently of its DNA binding domain, inhibits TRIP12-mediated ARF degradation through direct interaction with TRIP12 Nucleophosmin protects ARF from TRIP12-mediated ubiquitination by targeting it to the 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<body>References_begin: source UNIPROT References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="601.1646" y="4491.329"/> <port id="pr_0292692b-9ba3-4492-b8ab-3587b4a672d2_p1" x="591.1646" y="4496.329"/> <port id="pr_0292692b-9ba3-4492-b8ab-3587b4a672d2_p2" x="621.1646" y="4496.329"/> </glyph> <glyph class="process" orientation="vertical" id="pr_34a14766-4bf3-4d03-9723-e944cf51e73c"> <bbox w="10.0" h="10.0" x="1097.4994" y="3594.8306"/> <port id="pr_34a14766-4bf3-4d03-9723-e944cf51e73c_p1" x="1102.4994" y="3614.8306"/> <port id="pr_34a14766-4bf3-4d03-9723-e944cf51e73c_p2" x="1102.4994" y="3584.8306"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b027ee50-1057-4755-b9a5-e464ec22c8db"> <bbox w="10.0" h="10.0" x="882.0839" y="3833.3643"/> <port id="pr_b027ee50-1057-4755-b9a5-e464ec22c8db_p1" x="887.0839" y="3823.3643"/> <port id="pr_b027ee50-1057-4755-b9a5-e464ec22c8db_p2" x="887.0839" y="3853.3643"/> </glyph> <glyph class="omitted process" orientation="vertical" 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CCL-136), in murine skeletal muscle-derived C2C12 myoblasts (ATCC no. CRL-1772), by TP53 (luciferase reporter) upon transfection, but not by mutant TP53 in vitro binding of in vitro translated TP53 to the promoter References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4784.064" y="7232.25"/> <port id="pr_3b410a25-2217-4252-8497-7ad2e083dfc7_p1" x="4789.064" y="7252.25"/> <port id="pr_3b410a25-2217-4252-8497-7ad2e083dfc7_p2" x="4789.064" y="7222.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_684a51fc-321b-490c-9441-8bbad12b7c36"> <bbox w="10.0" h="10.0" x="2677.3455" y="3720.25"/> <port id="pr_684a51fc-321b-490c-9441-8bbad12b7c36_p1" x="2682.3455" y="3740.25"/> <port id="pr_684a51fc-321b-490c-9441-8bbad12b7c36_p2" x="2682.3455" y="3710.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b0ad72ab-8db3-4ee5-9d41-191d144956e8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20125124 by HTRA2 PMID:10521396 by CASP8 PMID:19935698 by CASP2 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5138.0" y="885.25"/> <port id="pr_b0ad72ab-8db3-4ee5-9d41-191d144956e8_p1" x="5143.0" y="875.25"/> <port id="pr_b0ad72ab-8db3-4ee5-9d41-191d144956e8_p2" x="5143.0" y="905.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_907ad1d0-1b6a-4d4c-80e2-3d7bd1e89be5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16839881 PMID:23030059 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4030.435" y="7204.0576"/> <port id="pr_907ad1d0-1b6a-4d4c-80e2-3d7bd1e89be5_p1" x="4035.435" y="7224.0576"/> <port id="pr_907ad1d0-1b6a-4d4c-80e2-3d7bd1e89be5_p2" x="4035.435" y="7194.0576"/> </glyph> <glyph class="process" 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y="5068.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7f6226c8-1f2b-40d8-8028-f0b589fecbaf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3218.5" y="5085.0"/> <port id="pr_7f6226c8-1f2b-40d8-8028-f0b589fecbaf_p1" x="3208.5" y="5090.0"/> <port id="pr_7f6226c8-1f2b-40d8-8028-f0b589fecbaf_p2" x="3238.5" y="5090.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_629cef66-e358-40b6-a956-37cbc59caa68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20823910 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" 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y="6659.25"/> <port id="pr_1aca32c6-a92f-42b5-8a0b-27b039d47e06_p2" x="6416.5" y="6689.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e6d83c46-04d4-44de-8d23-e411a1972ed8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6361.464" y="6669.0"/> <port id="pr_e6d83c46-04d4-44de-8d23-e411a1972ed8_p1" x="6351.464" y="6674.0"/> <port id="pr_e6d83c46-04d4-44de-8d23-e411a1972ed8_p2" x="6381.464" y="6674.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_83032ead-66c5-43b5-b47b-4881c3fd40dc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: 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id="pr_327d5942-708c-4038-9747-c574dc5509a3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6507.468" y="5828.643"/> <port id="pr_327d5942-708c-4038-9747-c574dc5509a3_p1" x="6497.468" y="5833.643"/> <port id="pr_327d5942-708c-4038-9747-c574dc5509a3_p2" x="6527.468" y="5833.643"/> </glyph> <glyph class="process" orientation="vertical" id="pr_89a50121-88b0-4096-bc9a-8cae3583c47b"> <bbox w="10.0" h="10.0" x="3894.8713" y="6327.75"/> <port id="pr_89a50121-88b0-4096-bc9a-8cae3583c47b_p1" x="3899.8713" y="6347.75"/> <port id="pr_89a50121-88b0-4096-bc9a-8cae3583c47b_p2" x="3899.8713" y="6317.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5711482b-e150-4d6c-a1ca-accda709c61b"> <notes> <html 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PMID:9915703 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4538.0" y="265.0"/> <port id="pr_a4cc3167-4b30-4751-86ce-8fc7fdd021db_p1" x="4558.0" y="270.0"/> <port id="pr_a4cc3167-4b30-4751-86ce-8fc7fdd021db_p2" x="4528.0" y="270.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c6516294-7a59-4a59-920a-a5937ef5dbf6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15310755 DAB2IP would be present at the membrane bound to TNF receptor even in the absence of stimulation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4995.0" y="535.0"/> <port id="pr_c6516294-7a59-4a59-920a-a5937ef5dbf6_p1" x="5000.0" y="525.0"/> <port id="pr_c6516294-7a59-4a59-920a-a5937ef5dbf6_p2" x="5000.0" y="555.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a845e8a2-ffcd-4d4c-87b1-a79915cd52b9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17389591 in aortic endothelial cells References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5011.5" y="667.625"/> <port id="pr_a845e8a2-ffcd-4d4c-87b1-a79915cd52b9_p1" x="5016.5" y="657.625"/> <port id="pr_a845e8a2-ffcd-4d4c-87b1-a79915cd52b9_p2" x="5016.5" y="687.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_51639b6f-8bcb-4d47-9ee3-8d7c1bedbc75"> <bbox w="10.0" h="10.0" x="5038.25" y="1932.0"/> <port id="pr_51639b6f-8bcb-4d47-9ee3-8d7c1bedbc75_p1" x="5028.25" y="1937.0"/> <port id="pr_51639b6f-8bcb-4d47-9ee3-8d7c1bedbc75_p2" x="5058.25" y="1937.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f380750a-320a-4258-b0d3-08550fb9f155"> <bbox w="10.0" h="10.0" x="5038.25" y="1985.0"/> <port id="pr_f380750a-320a-4258-b0d3-08550fb9f155_p1" x="5028.25" y="1990.0"/> <port id="pr_f380750a-320a-4258-b0d3-08550fb9f155_p2" x="5058.25" y="1990.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6f9c621f-04d1-43a7-9128-db8f88eb496b"> <bbox w="10.0" h="10.0" x="5039.75" y="2037.5"/> <port id="pr_6f9c621f-04d1-43a7-9128-db8f88eb496b_p1" x="5029.75" y="2042.5"/> <port id="pr_6f9c621f-04d1-43a7-9128-db8f88eb496b_p2" x="5059.75" y="2042.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_70ca9ead-bae4-4d30-9b09-e8c49bc75b69"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10688666 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4855.46" y="1552.0"/> <port id="pr_70ca9ead-bae4-4d30-9b09-e8c49bc75b69_p1" x="4860.46" y="1542.0"/> <port 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The abstract suggests that ASK1 activation could procede through autophosphorylation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5085.0" y="1570.0"/> <port id="pr_69e18399-2d20-4022-b7ba-160a728c8618_p1" x="5090.0" y="1560.0"/> <port id="pr_69e18399-2d20-4022-b7ba-160a728c8618_p2" x="5090.0" y="1590.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_69f59ff1-52cc-425e-a63c-94bbbf152035"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10411906 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4760.0" y="1455.0"/> <port id="pr_69f59ff1-52cc-425e-a63c-94bbbf152035_p1" x="4780.0" y="1460.0"/> <port id="pr_69f59ff1-52cc-425e-a63c-94bbbf152035_p2" x="4750.0" y="1460.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_db6475bc-ae08-4e06-a1ac-6e4f008854b1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10411906 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4607.0" y="1568.625"/> <port id="pr_db6475bc-ae08-4e06-a1ac-6e4f008854b1_p1" x="4627.0" y="1573.625"/> <port id="pr_db6475bc-ae08-4e06-a1ac-6e4f008854b1_p2" x="4597.0" y="1573.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_63aec81c-9113-4375-939a-d6d94a262c4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10411906 in Hela, overexpression of 14-3-3 isoform YWHAZ suppresses ASK1 overexpression-induced apoptosis PMID:18292600 by PP2A PMID:12813029 identification of DAB2IP as a negative regulator of ASK1:14-3-3 interaction AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4760.0" y="1475.0"/> <port id="pr_63aec81c-9113-4375-939a-d6d94a262c4b_p1" x="4750.0" y="1480.0"/> <port id="pr_63aec81c-9113-4375-939a-d6d94a262c4b_p2" x="4780.0" y="1480.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_a92cf1a3-b6a7-4ddb-b0f3-ba941e9ad255"> <bbox w="20.0" h="20.0" x="4789.928" y="1402.1721"/> <port id="logicglyph_a92cf1a3-b6a7-4ddb-b0f3-ba941e9ad255_p1" x="4799.928" y="1392.1721"/> <port id="logicglyph_a92cf1a3-b6a7-4ddb-b0f3-ba941e9ad255_p2" x="4799.928" y="1432.1721"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ed2023b3-7e72-4fcb-917f-060724987d52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4290.0" y="2057.0"/> <port id="pr_ed2023b3-7e72-4fcb-917f-060724987d52_p1" x="4280.0" y="2062.0"/> <port id="pr_ed2023b3-7e72-4fcb-917f-060724987d52_p2" x="4310.0" y="2062.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5e21a899-1aa8-4ac2-a876-f55d9711f04c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4335.0" y="2057.0"/> <port id="pr_5e21a899-1aa8-4ac2-a876-f55d9711f04c_p1" x="4340.0" y="2047.0"/> <port id="pr_5e21a899-1aa8-4ac2-a876-f55d9711f04c_p2" x="4340.0" y="2077.0"/> </glyph> <glyph class="process" orientation="horizontal" 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<glyph class="process" orientation="vertical" id="pr_a049903e-3a6e-449f-9e8b-40d4ef1e9968"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12624093 in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2KsPMID:19037093 under glucose deprivation condition, ROS are generated leading to an inactivation of JNK activity References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4315.0" y="2152.0"/> <port id="pr_a049903e-3a6e-449f-9e8b-40d4ef1e9968_p1" x="4320.0" y="2142.0"/> <port id="pr_a049903e-3a6e-449f-9e8b-40d4ef1e9968_p2" x="4320.0" y="2172.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7dfe14f0-7349-4298-8b57-b41fd2a796dc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11064451 DUSP1 PMID:11359773 DUSP16 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4335.0" y="2253.5"/> <port id="pr_7dfe14f0-7349-4298-8b57-b41fd2a796dc_p1" x="4340.0" y="2273.5"/> <port id="pr_7dfe14f0-7349-4298-8b57-b41fd2a796dc_p2" x="4340.0" y="2243.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_db375318-5652-4bfb-b511-8e3307aa3179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5415.0" y="2090.0"/> <port id="pr_db375318-5652-4bfb-b511-8e3307aa3179_p1" x="5435.0" y="2095.0"/> <port 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5414.5" y="2135.0"/> <port id="pr_4efa3a53-77e1-4a76-929d-e4f17d228642_p1" x="5434.5" y="2140.0"/> <port id="pr_4efa3a53-77e1-4a76-929d-e4f17d228642_p2" x="5404.5" y="2140.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_864b3e08-ba1b-4c24-82ba-20d670d39d62"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5415.0" y="2157.0"/> <port id="pr_864b3e08-ba1b-4c24-82ba-20d670d39d62_p1" x="5435.0" y="2162.0"/> <port id="pr_864b3e08-ba1b-4c24-82ba-20d670d39d62_p2" x="5405.0" y="2162.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ffabaf63-1021-4077-af74-b1a8e012b64c"> <bbox w="10.0" h="10.0" x="5285.0" y="2115.0"/> <port id="pr_ffabaf63-1021-4077-af74-b1a8e012b64c_p1" x="5305.0" y="2120.0"/> <port id="pr_ffabaf63-1021-4077-af74-b1a8e012b64c_p2" x="5275.0" y="2120.0"/> </glyph> <glyph class="or" orientation="vertical" id="logicglyph_81895fd6-3f80-4899-b5c9-bccf130fcbf8"> <bbox w="20.0" h="20.0" x="5274.755" y="1997.745"/> <port id="logicglyph_81895fd6-3f80-4899-b5c9-bccf130fcbf8_p1" x="5284.755" y="1987.745"/> <port id="logicglyph_81895fd6-3f80-4899-b5c9-bccf130fcbf8_p2" x="5284.755" y="2027.745"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_73e47702-27fc-476d-abeb-d520c915506f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11359773 by DUSP16 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5285.0" y="2135.0"/> <port id="pr_73e47702-27fc-476d-abeb-d520c915506f_p1" x="5275.0" y="2140.0"/> <port id="pr_73e47702-27fc-476d-abeb-d520c915506f_p2" x="5305.0" y="2140.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_820b5a45-abae-43b9-9d0d-fec9169ec977"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11689443 in 293T, in Hela, in L929, interaction between ectopically expressed tagged ASK1 and PPP5 in Hela, PPP5 expression inhibits ASK1 activity in vitro, purified ASK1 dephosphorylated by recombinant PPP5 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5045.0" y="1570.0"/> <port id="pr_820b5a45-abae-43b9-9d0d-fec9169ec977_p1" x="5050.0" y="1590.0"/> <port id="pr_820b5a45-abae-43b9-9d0d-fec9169ec977_p2" x="5050.0" y="1560.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1479f704-cc36-4c0d-aa2d-fa9b324e713a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9774977 ASK1 activation by TRAF2 upon TNF PMID:18292600 in vascular endothelial cell, by DAB2IP PMID:15310755 DAB2IP PMID:16252010 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4960.0" y="1465.0"/> <port id="pr_1479f704-cc36-4c0d-aa2d-fa9b324e713a_p1" x="4950.0" y="1470.0"/> <port id="pr_1479f704-cc36-4c0d-aa2d-fa9b324e713a_p2" x="4980.0" y="1470.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_7a61a2a1-d20b-4ec8-bfe3-9a1c88012284"> <bbox w="20.0" h="20.0" x="5007.0" y="1429.495"/> <port id="logicglyph_7a61a2a1-d20b-4ec8-bfe3-9a1c88012284_p1" x="5037.0" y="1439.495"/> <port id="logicglyph_7a61a2a1-d20b-4ec8-bfe3-9a1c88012284_p2" x="4997.0" y="1439.495"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7b52783c-2500-4464-b388-a1d25be6746d"> <notes> <html 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orientation="horizontal" id="pr_62b838e0-2663-4382-ad98-41d1bece98ab"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19131965 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5053.0" y="810.25"/> <port id="pr_62b838e0-2663-4382-ad98-41d1bece98ab_p1" x="5073.0" y="815.25"/> <port id="pr_62b838e0-2663-4382-ad98-41d1bece98ab_p2" x="5043.0" y="815.25"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_faf6af98-a1b7-4b1b-a476-b617cd62f5df"> <bbox w="20.0" h="20.0" x="4563.462" y="840.9545"/> <port id="logicglyph_faf6af98-a1b7-4b1b-a476-b617cd62f5df_p1" x="4553.462" y="850.9545"/> <port id="logicglyph_faf6af98-a1b7-4b1b-a476-b617cd62f5df_p2" x="4593.462" y="850.9545"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d99afd34-44b9-4283-adc3-ffed96877445"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23010170 TRADD recruits FADD and caspase-8, forming complex IIA, where caspase-8 is activated and apoptosis is initiated PMID:12887920 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4627.5" y="1224.6085"/> <port id="pr_d99afd34-44b9-4283-adc3-ffed96877445_p1" x="4647.5" y="1229.6085"/> <port id="pr_d99afd34-44b9-4283-adc3-ffed96877445_p2" x="4617.5" y="1229.6085"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1e91a167-29c9-48a1-bc4f-4d6183413fd4"> <bbox w="10.0" h="10.0" x="4806.26" y="1022.625"/> <port id="pr_1e91a167-29c9-48a1-bc4f-4d6183413fd4_p1" x="4811.26" y="1042.625"/> <port id="pr_1e91a167-29c9-48a1-bc4f-4d6183413fd4_p2" x="4811.26" y="1012.625"/> </glyph> <glyph class="process" orientation="horizontal" 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id="pr_d400901d-09a9-4e6c-a27b-8e1d1ec34e4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6544.0" y="1813.0"/> <port id="pr_d400901d-09a9-4e6c-a27b-8e1d1ec34e4b_p1" x="6534.0" y="1818.0"/> <port id="pr_d400901d-09a9-4e6c-a27b-8e1d1ec34e4b_p2" x="6564.0" y="1818.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_aff76756-618a-4f9a-ab7e-316ee56bf9ad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6544.0" y="1793.0"/> <port id="pr_aff76756-618a-4f9a-ab7e-316ee56bf9ad_p1" 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x="7341.25" y="4351.25"/> <port id="pr_1e87eaab-603e-4486-9674-481af5884478_p1" x="7331.25" y="4356.25"/> <port id="pr_1e87eaab-603e-4486-9674-481af5884478_p2" x="7361.25" y="4356.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b87fc29e-f5ff-4398-9f0e-4623988835f0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17446862 PMID:17106237 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9102.818" y="3405.5"/> <port id="pr_b87fc29e-f5ff-4398-9f0e-4623988835f0_p1" x="9107.818" y="3425.5"/> <port id="pr_b87fc29e-f5ff-4398-9f0e-4623988835f0_p2" x="9107.818" y="3395.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c8784ed0-eada-4201-a656-95e50c32df5d"> <bbox w="10.0" h="10.0" x="7569.75" y="4451.5"/> <port id="pr_c8784ed0-eada-4201-a656-95e50c32df5d_p1" x="7574.75" 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PMID:9694806 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7232.052" y="7202.3994"/> <port id="pr_5007d455-9dff-4bd8-92e6-d701d6548c29_p1" x="7237.052" y="7222.3994"/> <port id="pr_5007d455-9dff-4bd8-92e6-d701d6548c29_p2" x="7237.052" y="7192.3994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fe614f82-714e-4df1-b373-c97a12f5408d"> <bbox w="10.0" h="10.0" x="5356.0" y="7492.8477"/> <port id="pr_fe614f82-714e-4df1-b373-c97a12f5408d_p1" x="5376.0" y="7497.8477"/> <port id="pr_fe614f82-714e-4df1-b373-c97a12f5408d_p2" x="5346.0" y="7497.8477"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7bca796b-bf55-4b1b-b0ee-ea07e88a5cbc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5220.3174" y="2214.0"/> <port id="pr_7bca796b-bf55-4b1b-b0ee-ea07e88a5cbc_p1" x="5210.3174" y="2219.0"/> <port id="pr_7bca796b-bf55-4b1b-b0ee-ea07e88a5cbc_p2" x="5240.3174" y="2219.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_39b6bce1-c40b-4f3d-87f0-f9d777708bfe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15766528 in Hela, DUSP1-16-6-10, in response to TNF References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5358.0" y="2264.0"/> <port id="pr_39b6bce1-c40b-4f3d-87f0-f9d777708bfe_p1" x="5348.0" y="2269.0"/> <port id="pr_39b6bce1-c40b-4f3d-87f0-f9d777708bfe_p2" x="5378.0" y="2269.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cbdc0afb-a5c4-4fda-a537-f6ec4bdc228a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5217.706" y="2309.0"/> <port id="pr_d80c7de7-de0b-4a33-bf4c-b71729383a1b_p1" x="5207.706" y="2314.0"/> <port id="pr_d80c7de7-de0b-4a33-bf4c-b71729383a1b_p2" x="5237.706" y="2314.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2a6fbd28-30c8-4e7d-8207-9dba521a2948"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19203584 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="647.5" y="7240.0"/> <port id="pr_2a6fbd28-30c8-4e7d-8207-9dba521a2948_p1" x="667.5" y="7245.0"/> <port id="pr_2a6fbd28-30c8-4e7d-8207-9dba521a2948_p2" x="637.5" y="7245.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a42e635d-8768-4f7c-9d33-8999084c10eb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19203584 involvment of CRADD is doubtful References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="557.5" y="7190.0"/> <port id="pr_a42e635d-8768-4f7c-9d33-8999084c10eb_p1" x="562.5" y="7210.0"/> <port id="pr_a42e635d-8768-4f7c-9d33-8999084c10eb_p2" x="562.5" y="7180.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f9936136-901b-417b-8db8-4c5f05ad15e2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15073321 PMID:10973264 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3090.3506" y="7190.125"/> <port id="pr_f9936136-901b-417b-8db8-4c5f05ad15e2_p1" x="3095.3506" y="7210.125"/> <port 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class="process" orientation="horizontal" id="pr_61265277-d886-459f-9626-13f441655736"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18845789 unphosphorylated TP53 from coIP experiments with okadaic acid (PKC inhibitor) or ceramide C2 (potent inductor of PP1/2A PMID:26801188 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5220.5" y="4637.875"/> <port id="pr_61265277-d886-459f-9626-13f441655736_p1" x="5240.5" y="4642.875"/> <port id="pr_61265277-d886-459f-9626-13f441655736_p2" x="5210.5" y="4642.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f1a64e4e-3057-4c94-9c22-194f89598570"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5325.0" y="4467.5"/> <port id="pr_f1a64e4e-3057-4c94-9c22-194f89598570_p1" x="5330.0" y="4457.5"/> <port id="pr_f1a64e4e-3057-4c94-9c22-194f89598570_p2" x="5330.0" y="4487.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5daa1ff7-0613-4e2c-b9e4-71106fbe24e2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5325.0" y="4552.5"/> <port id="pr_5daa1ff7-0613-4e2c-b9e4-71106fbe24e2_p1" x="5330.0" y="4542.5"/> <port id="pr_5daa1ff7-0613-4e2c-b9e4-71106fbe24e2_p2" x="5330.0" y="4572.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2e1b8e52-953b-4551-b4dc-f1f1d1bfa509"> <notes> <html 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orientation="horizontal" id="pr_4027b25c-ec40-4b82-a637-01e31efbf370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15897452 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7346.75" y="5844.25"/> <port id="pr_4027b25c-ec40-4b82-a637-01e31efbf370_p1" x="7366.75" y="5849.25"/> <port id="pr_4027b25c-ec40-4b82-a637-01e31efbf370_p2" x="7336.75" y="5849.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fc795562-4bfb-4327-8138-4fa9b3cb8802"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20103683 in head and neck squamous cell carcinoma cells, enhanced TKTL1 expression and promoter hypomethylation TKTL1 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<body>References_begin: PMID:20865015 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4964.8394" y="6546.7695"/> <port id="pr_c281d977-da8c-4fbd-a307-d42480f8f4a6_p1" x="4969.8394" y="6536.7695"/> <port id="pr_c281d977-da8c-4fbd-a307-d42480f8f4a6_p2" x="4969.8394" y="6566.7695"/> </glyph> <glyph class="process" orientation="vertical" id="pr_86e8eb0b-017b-4683-947f-1047e4b13e1a"> <bbox w="10.0" h="10.0" x="3475.75" y="5797.5"/> <port id="pr_86e8eb0b-017b-4683-947f-1047e4b13e1a_p1" x="3480.75" y="5787.5"/> <port id="pr_86e8eb0b-017b-4683-947f-1047e4b13e1a_p2" x="3480.75" y="5817.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_72ec6a3f-e15e-45de-991d-7b7bd4924f3a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to products PMID:18087291 review, more specifically retention of NBN PMID:18001824 NBN interacts even with MDC1 mutated on its 3 phosphoacceptor sites References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="492.5" y="7670.0"/> <port id="pr_a70df922-193e-4e84-9ffe-32029201d63c_p1" x="512.5" y="7675.0"/> <port id="pr_a70df922-193e-4e84-9ffe-32029201d63c_p2" x="482.5" y="7675.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a30c95aa-f132-4141-9b4d-4b6d72aedefe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16377563 PMID:16049003 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="805.9204" y="7801.828"/> <port id="pr_a30c95aa-f132-4141-9b4d-4b6d72aedefe_p1" x="810.9204" y="7821.828"/> <port id="pr_a30c95aa-f132-4141-9b4d-4b6d72aedefe_p2" x="810.9204" y="7791.828"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9e031985-0b66-4fd9-b8b9-b33366dce5c5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18001824 PMID:18006705 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="807.5" y="7620.0"/> <port id="pr_9e031985-0b66-4fd9-b8b9-b33366dce5c5_p1" x="812.5" y="7640.0"/> <port id="pr_9e031985-0b66-4fd9-b8b9-b33366dce5c5_p2" x="812.5" y="7610.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2150c1e2-2da5-4792-ac18-224bfe89d8c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="722.5" y="7595.0"/> <port id="pr_2150c1e2-2da5-4792-ac18-224bfe89d8c7_p1" x="742.5" y="7600.0"/> <port id="pr_2150c1e2-2da5-4792-ac18-224bfe89d8c7_p2" x="712.5" y="7600.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9a24c3f4-3f82-4b34-b138-76b98839883e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="722.5" y="7640.0"/> <port id="pr_9a24c3f4-3f82-4b34-b138-76b98839883e_p1" x="742.5" y="7645.0"/> <port id="pr_9a24c3f4-3f82-4b34-b138-76b98839883e_p2" x="712.5" y="7645.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_00fb9e1f-60b7-42d1-bfa7-0931d97bc903"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18411308 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="804.6704" y="7969.328"/> <port id="pr_00fb9e1f-60b7-42d1-bfa7-0931d97bc903_p1" x="809.6704" y="7989.328"/> <port id="pr_00fb9e1f-60b7-42d1-bfa7-0931d97bc903_p2" x="809.6704" y="7959.328"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_937e3ae8-5718-4997-aee8-e66eab61e38f"> <bbox w="10.0" h="10.0" x="420.75" y="7740.547"/> <port id="pr_937e3ae8-5718-4997-aee8-e66eab61e38f_p1" x="410.75" y="7745.547"/> <port id="pr_937e3ae8-5718-4997-aee8-e66eab61e38f_p2" x="440.75" y="7745.547"/> </glyph> <glyph class="process" orientation="vertical" id="pr_603abab2-50ee-489e-b57f-3e1e36b03163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants PMID:17486112 by NBN References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1017.5" y="7872.5"/> <port id="pr_603abab2-50ee-489e-b57f-3e1e36b03163_p1" x="1022.5" y="7892.5"/> <port id="pr_603abab2-50ee-489e-b57f-3e1e36b03163_p2" x="1022.5" y="7862.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c0c964ed-b8dc-4eba-87f3-6614ba639567"> <bbox w="10.0" h="10.0" x="999.2808" y="7747.549"/> <port id="pr_c0c964ed-b8dc-4eba-87f3-6614ba639567_p1" x="1004.2808" y="7767.549"/> <port id="pr_c0c964ed-b8dc-4eba-87f3-6614ba639567_p2" x="1004.2808" y="7737.549"/> </glyph> <glyph class="process" orientation="vertical" id="pr_35439f69-25fc-4e6c-b2f7-1a6190673131"> <bbox w="10.0" h="10.0" x="1040.7808" y="7747.549"/> <port id="pr_35439f69-25fc-4e6c-b2f7-1a6190673131_p1" x="1045.7808" y="7737.549"/> <port id="pr_35439f69-25fc-4e6c-b2f7-1a6190673131_p2" x="1045.7808" y="7767.549"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f1ebdaf6-f2d3-42c3-9bce-3de55191ef55"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants PMID:9488723 PMID:11571274 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="587.5" y="7550.0"/> <port id="pr_f1ebdaf6-f2d3-42c3-9bce-3de55191ef55_p1" x="577.5" y="7555.0"/> <port id="pr_f1ebdaf6-f2d3-42c3-9bce-3de55191ef55_p2" x="607.5" y="7555.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dc230a74-62d6-4f3b-9ece-e8ee02ac2a2e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20118229 by PPM1D PMID:20101220 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="587.5" y="7530.0"/> <port id="pr_dc230a74-62d6-4f3b-9ece-e8ee02ac2a2e_p1" x="607.5" y="7535.0"/> <port id="pr_dc230a74-62d6-4f3b-9ece-e8ee02ac2a2e_p2" x="577.5" y="7535.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_47c3d6b7-cc67-477e-816c-310557e196b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: reactants to re PMID:19092802 by WICH complex (subunit identification by mass spectrometry: WSTF and SNF2H) PMID:19234442 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="467.5" y="7495.0"/> <port id="pr_47c3d6b7-cc67-477e-816c-310557e196b2_p1" x="472.5" y="7515.0"/> <port id="pr_47c3d6b7-cc67-477e-816c-310557e196b2_p2" x="472.5" y="7485.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_74ce0a4e-fea2-4e60-815c-0defa13b4678"> <bbox w="10.0" h="10.0" x="297.5" y="7491.0"/> <port id="pr_74ce0a4e-fea2-4e60-815c-0defa13b4678_p1" x="287.5" y="7496.0"/> <port id="pr_74ce0a4e-fea2-4e60-815c-0defa13b4678_p2" x="317.5" y="7496.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4d597b34-e79f-4c4e-bfd3-14ff2187c93f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="583.75" y="7345.0"/> <port id="pr_4d597b34-e79f-4c4e-bfd3-14ff2187c93f_p1" x="603.75" y="7350.0"/> <port id="pr_4d597b34-e79f-4c4e-bfd3-14ff2187c93f_p2" x="573.75" y="7350.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_594980da-9224-44ee-931d-caafda0fb181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="583.75" y="7370.0"/> <port id="pr_594980da-9224-44ee-931d-caafda0fb181_p1" x="603.75" y="7375.0"/> <port id="pr_594980da-9224-44ee-931d-caafda0fb181_p2" x="573.75" y="7375.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a3bc3b60-2935-48eb-9b58-fbd06c0500f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16818236 upon UVA irradiation (no DSB), phosphorylation of H2AX S139 by JNK effect of Y142 phosphorylation not assessed PMID:19234442 interaction between JNK1 and H2AX Y142_pho dependent on FE65 (proposed FE65 scaffolding JNK to Y142_pho) they propose H2AX Y142 phosphorylation as a switch toward apoptosis. Even if not fully documented, the information from these 2 papers is merged into this representation where doubly phosphorylated H2AX cooperated with CAD for DNA fragmentation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="467.5" y="7375.0"/> <port id="pr_a3bc3b60-2935-48eb-9b58-fbd06c0500f6_p1" x="472.5" y="7395.0"/> <port id="pr_a3bc3b60-2935-48eb-9b58-fbd06c0500f6_p2" x="472.5" y="7365.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_dd03cdb1-1c63-40f5-b4f3-8eab52c426c8"> <bbox w="20.0" h="20.0" x="384.53247" y="7377.8887"/> <port id="logicglyph_dd03cdb1-1c63-40f5-b4f3-8eab52c426c8_p1" x="374.53247" y="7387.8887"/> <port id="logicglyph_dd03cdb1-1c63-40f5-b4f3-8eab52c426c8_p2" x="414.53247" y="7387.8887"/> </glyph> <glyph class="process" orientation="vertical" id="pr_488323a1-a632-4e34-8fe7-26a23c37529f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19234442 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="487.5" y="7495.0"/> <port id="pr_488323a1-a632-4e34-8fe7-26a23c37529f_p1" x="492.5" y="7485.0"/> <port id="pr_488323a1-a632-4e34-8fe7-26a23c37529f_p2" x="492.5" y="7515.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ce611b13-680b-4204-b8ec-bc20ce4eb668"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to products PMID:18087291 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1433.75" y="7697.5"/> <port id="pr_ce611b13-680b-4204-b8ec-bc20ce4eb668_p1" x="1438.75" y="7717.5"/> <port id="pr_ce611b13-680b-4204-b8ec-bc20ce4eb668_p2" x="1438.75" y="7687.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b042a754-1486-4b03-b803-7c05d2a0ef50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to products PMID:18087291 review References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1062.5703" y="7562.948"/> <port id="pr_b042a754-1486-4b03-b803-7c05d2a0ef50_p1" x="1067.5703" y="7582.948"/> <port id="pr_b042a754-1486-4b03-b803-7c05d2a0ef50_p2" x="1067.5703" y="7552.948"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ee18f12b-5c63-44a5-aa1d-d57387bfd727"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants PMID:18001824 PMID:18006705 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1348.5" y="7860.0"/> <port id="pr_ee18f12b-5c63-44a5-aa1d-d57387bfd727_p1" x="1353.5" y="7880.0"/> <port id="pr_ee18f12b-5c63-44a5-aa1d-d57387bfd727_p2" x="1353.5" y="7850.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_09c0122f-1b33-4871-a944-8576fe43446a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19203579 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1473.75" y="7592.5"/> <port id="pr_09c0122f-1b33-4871-a944-8576fe43446a_p1" x="1478.75" y="7582.5"/> <port id="pr_09c0122f-1b33-4871-a944-8576fe43446a_p2" x="1478.75" y="7612.5"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_522da8d3-85de-445c-b7c5-8455cb6d2558"> <bbox w="20.0" h="20.0" x="1513.7728" y="7523.5137"/> <port 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id="pr_7f08bc90-a90a-4154-97cb-9297a9404975_p1" x="1540.0" y="7795.0"/> <port id="pr_7f08bc90-a90a-4154-97cb-9297a9404975_p2" x="1510.0" y="7795.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_01550e0e-bf82-4e46-ac96-8702458b223f"> <bbox w="10.0" h="10.0" x="1433.75" y="7592.5"/> <port id="pr_01550e0e-bf82-4e46-ac96-8702458b223f_p1" x="1438.75" y="7612.5"/> <port id="pr_01550e0e-bf82-4e46-ac96-8702458b223f_p2" x="1438.75" y="7582.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f4f41123-42fe-46d5-b7d1-19b72d0fed97"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1081.75" y="7517.457"/> <port id="pr_f4f41123-42fe-46d5-b7d1-19b72d0fed97_p1" x="1071.75" y="7522.457"/> <port id="pr_f4f41123-42fe-46d5-b7d1-19b72d0fed97_p2" x="1101.75" y="7522.457"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c8ab644c-6369-4ec0-98b7-f8cdfe60c668"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants PMID:19342239 review genetic arguments for the components of this complex being recruited all together References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1238.0" y="7519.7363"/> <port id="pr_c8ab644c-6369-4ec0-98b7-f8cdfe60c668_p1" x="1228.0" y="7524.7363"/> <port id="pr_c8ab644c-6369-4ec0-98b7-f8cdfe60c668_p2" x="1258.0" y="7524.7363"/> </glyph> <glyph class="process" orientation="vertical" id="pr_271dea8a-81d6-453d-91fe-71ac295a3771"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: influenceDelete: re to reactants References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1473.75" y="7697.5"/> <port id="pr_271dea8a-81d6-453d-91fe-71ac295a3771_p1" x="1478.75" y="7687.5"/> <port id="pr_271dea8a-81d6-453d-91fe-71ac295a3771_p2" x="1478.75" y="7717.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5553cd80-666d-4f8e-95c7-b896013f2e46"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="961.12" y="7874.0"/> <port id="pr_5553cd80-666d-4f8e-95c7-b896013f2e46_p1" x="966.12" y="7864.0"/> <port id="pr_5553cd80-666d-4f8e-95c7-b896013f2e46_p2" x="966.12" y="7894.0"/> </glyph> <glyph class="process" 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9465.0" y="2510.0"/> <port id="pr_a22c3fef-11c3-431c-86b0-e6f0f2b4e36a_p1" x="9455.0" y="2515.0"/> <port id="pr_a22c3fef-11c3-431c-86b0-e6f0f2b4e36a_p2" x="9485.0" y="2515.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cf709bf9-d69e-464c-9183-68e5b6165abd"> <bbox w="10.0" h="10.0" x="9592.5" y="2510.0"/> <port id="pr_cf709bf9-d69e-464c-9183-68e5b6165abd_p1" x="9582.5" y="2515.0"/> <port id="pr_cf709bf9-d69e-464c-9183-68e5b6165abd_p2" x="9612.5" y="2515.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dad0d550-6fe2-42b0-af67-ed36d30a5c9c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19446321 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9264.0" y="2345.2637"/> <port 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5253.0" y="810.25"/> <port id="pr_f00d5200-64f6-4bc4-8ed8-3f109d4a6cfb_p1" x="5243.0" y="815.25"/> <port id="pr_f00d5200-64f6-4bc4-8ed8-3f109d4a6cfb_p2" x="5273.0" y="815.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ad395e0c-2332-4081-aad6-e0804a1dd5c8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19498109 RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3757.75" y="751.0"/> <port id="pr_ad395e0c-2332-4081-aad6-e0804a1dd5c8_p1" x="3777.75" y="756.0"/> <port id="pr_ad395e0c-2332-4081-aad6-e0804a1dd5c8_p2" x="3747.75" y="756.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_14cd500a-56e9-4579-93be-fc71e132c697"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22421439 Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. MLKL functions downstream of RIP1 and RIP3 and is recruited to the necrosome through its interaction with RIP3 PMID:23073834 new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI PMID:19632174 RIP3 directly interacts with glycogen phosphorylase (PYGL), glutamate ammonia ligase (GLUL), and glutamate dehydrogenase 1 (GLUD1 PMID:20823910 Molecular mechanisms of necroptosis: an ordered cellular explosion PMID:27959630 PMID:26024392 The phosphorylation of Ser345 is not required for the interaction between RIPK3 and MLKL in the necrosome, but is essential for MLKL translocation, accumulation in the plasma membrane, and consequent necroptosis. 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PMID:22265414 PGAM5S recruited the mitochondrial fission factor Drp1 and activated its GTPase activity by dephosphorylating the serine 637 site of Drp1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2265.5" y="987.0"/> <port id="pr_9ae5b89b-d070-4e17-9f01-22b798b25206_p1" x="2270.5" y="977.0"/> <port id="pr_9ae5b89b-d070-4e17-9f01-22b798b25206_p2" x="2270.5" y="1007.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e50926fb-4184-4517-97c3-0c2021bc6435"> <bbox w="10.0" h="10.0" x="2503.5" y="1245.75"/> <port id="pr_e50926fb-4184-4517-97c3-0c2021bc6435_p1" x="2508.5" y="1235.75"/> <port id="pr_e50926fb-4184-4517-97c3-0c2021bc6435_p2" x="2508.5" y="1265.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_83dab4ea-80b2-40b9-927c-28759eb52fa6"> <bbox w="10.0" h="10.0" x="2573.5" y="1247.0"/> <port id="pr_83dab4ea-80b2-40b9-927c-28759eb52fa6_p1" x="2578.5" y="1237.0"/> <port id="pr_83dab4ea-80b2-40b9-927c-28759eb52fa6_p2" x="2578.5" y="1267.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d1a3386c-ee9c-4369-a3fc-f77a6c690be3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23073834 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2265.231" y="1089.75"/> <port id="pr_d1a3386c-ee9c-4369-a3fc-f77a6c690be3_p1" x="2270.231" y="1079.75"/> <port id="pr_d1a3386c-ee9c-4369-a3fc-f77a6c690be3_p2" x="2270.231" y="1109.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dbf080c4-c4ce-4c1b-a569-2aaefe80ac51"> <bbox w="10.0" h="10.0" x="2461.5" y="1149.5"/> <port id="pr_dbf080c4-c4ce-4c1b-a569-2aaefe80ac51_p1" x="2466.5" y="1139.5"/> <port id="pr_dbf080c4-c4ce-4c1b-a569-2aaefe80ac51_p2" x="2466.5" y="1169.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_93e168cc-26ac-41ea-ab14-2205cb240ac9"> <bbox w="10.0" h="10.0" x="2609.9688" y="1150.75"/> <port id="pr_93e168cc-26ac-41ea-ab14-2205cb240ac9_p1" x="2614.9688" y="1140.75"/> <port id="pr_93e168cc-26ac-41ea-ab14-2205cb240ac9_p2" x="2614.9688" y="1170.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a65f723f-2aec-4b16-907c-c44b8c709711"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19037093 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4245.0" y="1952.0"/> <port id="pr_a65f723f-2aec-4b16-907c-c44b8c709711_p1" x="4250.0" y="1972.0"/> <port id="pr_a65f723f-2aec-4b16-907c-c44b8c709711_p2" x="4250.0" y="1942.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cc02a8cf-338a-4468-9068-f935362f6034"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Tumor necrosis factor-alpha-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool. 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4075.0" y="1746.0"/> <port id="pr_d87b813b-2c10-4111-a571-00fdd342a417_p1" x="4080.0" y="1766.0"/> <port id="pr_d87b813b-2c10-4111-a571-00fdd342a417_p2" x="4080.0" y="1736.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_906e5e94-7ac1-439d-8cd7-aeb589488452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17603935 Tumor necrosis factor-alpha-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4195.0" y="1748.0"/> <port id="pr_906e5e94-7ac1-439d-8cd7-aeb589488452_p1" x="4200.0" y="1768.0"/> <port id="pr_906e5e94-7ac1-439d-8cd7-aeb589488452_p2" x="4200.0" y="1738.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_078cde8d-b3d6-4d37-ae1c-9e600479ee5d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16469705 The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4375.0" y="1892.0"/> <port id="pr_078cde8d-b3d6-4d37-ae1c-9e600479ee5d_p1" x="4380.0" y="1912.0"/> <port id="pr_078cde8d-b3d6-4d37-ae1c-9e600479ee5d_p2" x="4380.0" y="1882.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1af38b5b-61c6-40c7-bf7b-eb8f0facf75a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16469705 JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L). 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PMID:26801188 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2433.75" y="1402.5"/> <port id="pr_6bd1895e-ff5a-49a6-9030-e7e58c1f02d6_p1" x="2438.75" y="1422.5"/> <port id="pr_6bd1895e-ff5a-49a6-9030-e7e58c1f02d6_p2" x="2438.75" y="1392.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ac88290d-dba4-486b-acf6-a8ff08354bb9"> <bbox w="10.0" h="10.0" x="2453.75" y="1402.5"/> <port id="pr_ac88290d-dba4-486b-acf6-a8ff08354bb9_p1" x="2458.75" y="1392.5"/> <port id="pr_ac88290d-dba4-486b-acf6-a8ff08354bb9_p2" x="2458.75" y="1422.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5eb238ec-1064-4904-b51f-8443857c7fbc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10792026 Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2900.0" y="1795.0"/> <port id="pr_5eb238ec-1064-4904-b51f-8443857c7fbc_p1" x="2890.0" y="1800.0"/> <port id="pr_5eb238ec-1064-4904-b51f-8443857c7fbc_p2" x="2920.0" y="1800.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1b57f6c6-0ead-4325-a0a0-7d013b261a01"> <bbox w="10.0" h="10.0" x="3027.5" y="1795.0"/> <port id="pr_1b57f6c6-0ead-4325-a0a0-7d013b261a01_p1" x="3017.5" y="1800.0"/> <port id="pr_1b57f6c6-0ead-4325-a0a0-7d013b261a01_p2" x="3047.5" y="1800.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_59084a0e-8fc1-48c6-8fc2-72d40d8550fc"> <bbox w="10.0" h="10.0" x="4552.0" y="1486.2155"/> <port id="pr_59084a0e-8fc1-48c6-8fc2-72d40d8550fc_p1" x="4572.0" y="1491.2155"/> <port id="pr_59084a0e-8fc1-48c6-8fc2-72d40d8550fc_p2" x="4542.0" y="1491.2155"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_34f51da1-3549-41e9-afd1-b11ac0afa1c1"> <bbox w="10.0" h="10.0" x="3446.25" y="1672.5"/> <port id="pr_34f51da1-3549-41e9-afd1-b11ac0afa1c1_p1" x="3466.25" y="1677.5"/> <port id="pr_34f51da1-3549-41e9-afd1-b11ac0afa1c1_p2" x="3436.25" y="1677.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ebd52b70-e37f-4177-9ac8-557cda5a77de"> <bbox w="10.0" h="10.0" x="3446.25" y="1707.5"/> <port id="pr_ebd52b70-e37f-4177-9ac8-557cda5a77de_p1" x="3466.25" y="1712.5"/> <port id="pr_ebd52b70-e37f-4177-9ac8-557cda5a77de_p2" x="3436.25" y="1712.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_abf6da4f-b7ba-498a-8b13-eecc352227b3"> <bbox w="10.0" h="10.0" x="2754.625" y="1887.5577"/> <port id="pr_abf6da4f-b7ba-498a-8b13-eecc352227b3_p1" x="2744.625" y="1892.5577"/> <port id="pr_abf6da4f-b7ba-498a-8b13-eecc352227b3_p2" x="2774.625" y="1892.5577"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a090a311-f44c-4e8d-992c-844d008399fe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9443821 phingosine potentiates the transduction process of stimulus-PLA2 activation, resulting in enhancement of arachidonic acid liberation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3255.0" y="1830.0"/> <port id="pr_a090a311-f44c-4e8d-992c-844d008399fe_p1" x="3260.0" y="1820.0"/> <port id="pr_a090a311-f44c-4e8d-992c-844d008399fe_p2" x="3260.0" y="1850.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3323d9f5-df62-46bb-9928-a626b457a4da"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2139.903" y="4509.75"/> <port id="pr_3323d9f5-df62-46bb-9928-a626b457a4da_p1" x="2144.903" y="4499.75"/> <port id="pr_3323d9f5-df62-46bb-9928-a626b457a4da_p2" x="2144.903" y="4529.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_92851597-b831-43f3-a916-92d44893782a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22476944 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3376.25" y="1757.5"/> <port id="pr_92851597-b831-43f3-a916-92d44893782a_p1" x="3381.25" y="1747.5"/> <port id="pr_92851597-b831-43f3-a916-92d44893782a_p2" x="3381.25" y="1777.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_07077a93-741c-486a-8f90-13931ce3bfa0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9443821 phingosine potentiates the transduction process of stimulus-PLA2 activation, resulting in enhancement of arachidonic acid liberation PMID:22454477 Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. 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PMID:11085742 in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria PMID:10364179 cleavage of BID by CASP8 and CASP3 PMID:11832478 in vitro by CASP2 PMID:18955971 LMP causes the proteolytic activation of Bid (which is cleaved by the two lysosomal cathepsins B and D), which then induces MOMP References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3307.5" y="2449.0"/> <port id="pr_f6629087-a161-4b3b-8d6f-a11fcfd77294_p1" x="3327.5" y="2454.0"/> <port id="pr_f6629087-a161-4b3b-8d6f-a11fcfd77294_p2" x="3297.5" y="2454.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fb1cfe4e-fa6c-4d85-bf79-6f141415f6d7"> <bbox w="10.0" h="10.0" x="2975.0" y="2160.0"/> <port id="pr_fb1cfe4e-fa6c-4d85-bf79-6f141415f6d7_p1" x="2980.0" y="2180.0"/> <port id="pr_fb1cfe4e-fa6c-4d85-bf79-6f141415f6d7_p2" x="2980.0" y="2150.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6c183a0e-8768-45c5-aca0-480306ee0ffb"> <notes> <html 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<glyph class="process" orientation="horizontal" id="pr_bcfcf5d6-a455-48d7-80f9-108f3a72def0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9242610 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6537.0" y="160.63635"/> <port id="pr_bcfcf5d6-a455-48d7-80f9-108f3a72def0_p1" x="6527.0" y="165.63635"/> <port id="pr_bcfcf5d6-a455-48d7-80f9-108f3a72def0_p2" x="6557.0" y="165.63635"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ae79e27-2f0f-4a28-8ef1-4d0431bbf299"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19090789 Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling PMID:17767167 Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. PMID:10894161 Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5 PMID:28258062 The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="6697.5" y="196.05978"/> <port id="pr_0ae79e27-2f0f-4a28-8ef1-4d0431bbf299_p1" x="6687.5" y="201.05978"/> <port id="pr_0ae79e27-2f0f-4a28-8ef1-4d0431bbf299_p2" x="6717.5" y="201.05978"/> </glyph> <glyph class="process" orientation="vertical" id="pr_377eb4ea-e048-44c3-b159-371136e6dc4e"> <bbox w="10.0" h="10.0" x="6915.0" y="370.0"/> <port id="pr_377eb4ea-e048-44c3-b159-371136e6dc4e_p1" x="6920.0" y="390.0"/> <port id="pr_377eb4ea-e048-44c3-b159-371136e6dc4e_p2" x="6920.0" y="360.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6fd21acf-5c0e-41d1-9a01-f3a4a9d1cec3"> <bbox w="10.0" h="10.0" x="6860.0" y="370.0"/> <port id="pr_6fd21acf-5c0e-41d1-9a01-f3a4a9d1cec3_p1" x="6865.0" y="390.0"/> <port id="pr_6fd21acf-5c0e-41d1-9a01-f3a4a9d1cec3_p2" x="6865.0" y="360.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_90db2f60-f1b7-41b0-b076-fa2f93c392dc"> <notes> <html 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19427028 Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7265.75" y="246.25339"/> <port id="pr_2d860f6a-84de-4f71-9347-e6d5ac49378e_p1" x="7255.75" y="251.25339"/> <port id="pr_2d860f6a-84de-4f71-9347-e6d5ac49378e_p2" x="7285.75" y="251.25339"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_21f26fbb-f44e-4ac9-ae0a-ebb6d98c40a7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20599425 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7253.75" y="195.0"/> <port id="pr_21f26fbb-f44e-4ac9-ae0a-ebb6d98c40a7_p1" x="7273.75" y="200.0"/> <port 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p62-dependent foci, leading to full activation and processing of the enzyme and driving commitment to cell death References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7389.2744" y="586.71875"/> <port id="pr_cf77e966-ddb5-409f-9331-732faf18b645_p1" x="7394.2744" y="576.71875"/> <port id="pr_cf77e966-ddb5-409f-9331-732faf18b645_p2" x="7394.2744" y="606.71875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_33c7abb9-b6d9-4670-b8a7-782137c86e5d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15760909 endogenous c-FLIP(L) functions primarily as an inhibitor of death receptor-mediated apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7621.0938" y="195.0"/> <port id="pr_33c7abb9-b6d9-4670-b8a7-782137c86e5d_p1" x="7611.0938" y="200.0"/> <port 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y="3805.0"/> <port id="pr_00c21419-5144-4cf3-b223-10bfcd44314b_p1" x="6177.5" y="3810.0"/> <port id="pr_00c21419-5144-4cf3-b223-10bfcd44314b_p2" x="6207.5" y="3810.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_986ecf47-ff63-42ea-b185-1bfc95c12f40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21887410 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5062.5" y="3599.6528"/> <port id="pr_986ecf47-ff63-42ea-b185-1bfc95c12f40_p1" x="5082.5" y="3604.6528"/> <port id="pr_986ecf47-ff63-42ea-b185-1bfc95c12f40_p2" x="5052.5" y="3604.6528"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7eb35c72-5ad8-465e-8553-121d98e5bce9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface PMID:12724420 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="8016.4473" y="287.5"/> <port id="pr_3fe4d8b0-7951-490c-8af4-58585cf7560a_p1" x="8036.4473" y="292.5"/> <port id="pr_3fe4d8b0-7951-490c-8af4-58585cf7560a_p2" x="8006.4473" y="292.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4c61378e-c91e-4b60-be3f-5e0daa58d76d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23069999 At least five levels of life-death cell regulation via CD95 could be tracked: extracellular, membrane, DISC, mitochondrial, and miRNA References_end </body> 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id="pr_23d18966-7014-4e1d-8100-4afb78c7e180"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 PMID:20173780 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1708.0514" y="269.4311"/> <port id="pr_23d18966-7014-4e1d-8100-4afb78c7e180_p1" x="1698.0514" y="274.4311"/> <port id="pr_23d18966-7014-4e1d-8100-4afb78c7e180_p2" x="1728.0514" y="274.4311"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2916be9b-4a35-4a80-8bd7-c5788fd89cee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19543238 Interfering with multimerization of netrin-1 receptors triggers tumor cell death References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1428.5514" y="175.31999"/> <port id="pr_2916be9b-4a35-4a80-8bd7-c5788fd89cee_p1" x="1418.5514" y="180.31999"/> <port id="pr_2916be9b-4a35-4a80-8bd7-c5788fd89cee_p2" x="1448.5514" y="180.31999"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_533ae606-d495-49b1-99d5-ee5bb5722123"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12011067 DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="1550.0514" y="267.07394"/> <port id="pr_533ae606-d495-49b1-99d5-ee5bb5722123_p1" x="1540.0514" y="272.07394"/> <port id="pr_533ae606-d495-49b1-99d5-ee5bb5722123_p2" x="1570.0514" y="272.07394"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2ea65ee1-add3-4e23-b962-06889cfc912e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19543238 PMID:21172653 The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1 in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2023.0" y="232.18163"/> <port id="pr_2ea65ee1-add3-4e23-b962-06889cfc912e_p1" x="2013.0" y="237.18163"/> <port id="pr_2ea65ee1-add3-4e23-b962-06889cfc912e_p2" x="2043.0" y="237.18163"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_00e8bcec-f720-4598-a387-4499036f08d6"> <notes> <html 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changes that enable binding of the PR65b subunit of PP2A. This drives dephosphorylation and activation of DAPK, thereby inducing proapoptotic signaling References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2212.026" y="284.4311"/> <port id="pr_232bf0d1-1aab-4273-ab9c-0c47cfdc4694_p1" x="2202.026" y="289.4311"/> <port id="pr_232bf0d1-1aab-4273-ab9c-0c47cfdc4694_p2" x="2232.026" y="289.4311"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2a3e0c3d-d35f-460c-855b-fe3ab21b8cc0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19543238 PMID:21172653 The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2526.0515" y="185.7811"/> <port id="pr_2a3e0c3d-d35f-460c-855b-fe3ab21b8cc0_p1" x="2516.0515" y="190.7811"/> <port id="pr_2a3e0c3d-d35f-460c-855b-fe3ab21b8cc0_p2" x="2546.0515" y="190.7811"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7f003567-2c5c-4fc3-85a0-6177fae6e10a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12376548 NRAGE may act to sequester and inactivate XIAP, leading to a potentiation of caspase-mediated cell death in a promyeloid leukemic cell line PMID:11546791 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2690.0515" y="334.4311"/> <port id="pr_7f003567-2c5c-4fc3-85a0-6177fae6e10a_p1" x="2680.0515" y="339.4311"/> <port id="pr_7f003567-2c5c-4fc3-85a0-6177fae6e10a_p2" x="2710.0515" y="339.4311"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_be523894-c8a2-4ebd-97e1-62f099fbe760"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19465923 in the absence of Shh, Ptc recruits a protein complex that includes DRAL, one of the caspase recruitment (CARD)-domain containing proteins TUCAN (family member, 8) or NALP1 (NLR family, pyrin domain containing 1) and apical caspase-9 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3037.0" y="236.33334"/> <port id="pr_be523894-c8a2-4ebd-97e1-62f099fbe760_p1" x="3027.0" y="241.33334"/> <port id="pr_be523894-c8a2-4ebd-97e1-62f099fbe760_p2" x="3057.0" y="241.33334"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8542d096-b697-4d64-83c1-ece0d58260c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20495383 In the absence of SHH; Patched recruits a dral-tucan complex that lead to apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="2903.5" y="190.0"/> <port id="pr_8542d096-b697-4d64-83c1-ece0d58260c7_p1" x="2893.5" y="195.0"/> <port id="pr_8542d096-b697-4d64-83c1-ece0d58260c7_p2" x="2923.5" y="195.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cd015be4-9172-4192-b4a2-42136a0492be"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22679284 Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3120.0" y="525.0"/> <port id="pr_cd015be4-9172-4192-b4a2-42136a0492be_p1" x="3110.0" y="530.0"/> <port id="pr_cd015be4-9172-4192-b4a2-42136a0492be_p2" x="3140.0" y="530.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_214c0e6b-9ce3-4650-8e35-a67bffe690e1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22465479 PI3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), in a reaction that can be reversed by the PIP3 phosphatase PTEN References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3275.0" y="385.0"/> <port id="pr_214c0e6b-9ce3-4650-8e35-a67bffe690e1_p1" x="3265.0" y="390.0"/> <port id="pr_214c0e6b-9ce3-4650-8e35-a67bffe690e1_p2" x="3295.0" y="390.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bdecd3ce-fa24-4597-ba47-d6b1ab37b896"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19203586 PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, thereby inhibiting Akt translocation to the cellular membrane and activation PMID:15718470 TORC2 complex as AKT S473 kinase PMID:17604717 PDK1 phosphorylates the activation loop of AKT at T308 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3520.0" y="495.0"/> <port id="pr_bdecd3ce-fa24-4597-ba47-d6b1ab37b896_p1" x="3540.0" y="500.0"/> <port id="pr_bdecd3ce-fa24-4597-ba47-d6b1ab37b896_p2" x="3510.0" y="500.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c94f3517-bf62-43d0-8123-2dcfb08bd559"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17604717 AKT and PDK1 bind to PIP3 at the plasma membrane, References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3437.0" y="385.0"/> <port id="pr_c94f3517-bf62-43d0-8123-2dcfb08bd559_p1" x="3427.0" y="390.0"/> <port id="pr_c94f3517-bf62-43d0-8123-2dcfb08bd559_p2" x="3457.0" y="390.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_89ba9bde-2dd0-4c97-94bc-1ebf6d3fe90e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3328.0" y="230.4"/> <port id="pr_89ba9bde-2dd0-4c97-94bc-1ebf6d3fe90e_p1" x="3348.0" y="235.4"/> <port id="pr_89ba9bde-2dd0-4c97-94bc-1ebf6d3fe90e_p2" x="3318.0" y="235.4"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a65e2b70-6567-4b45-98bd-7dd2bb849c55"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16939974 neurotrophin binding to Trk receptors results in receptor dimerization and autophosphorylation of their cytoplasmic kinase domains References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3510.5" y="175.0"/> <port id="pr_a65e2b70-6567-4b45-98bd-7dd2bb849c55_p1" x="3530.5" y="180.0"/> <port id="pr_a65e2b70-6567-4b45-98bd-7dd2bb849c55_p2" x="3500.5" y="180.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3120bb93-72be-4602-9e14-8fe6a13b6eb5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22465479 PI3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), in a reaction that can be reversed by the PIP3 phosphatase PTEN References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3275.0" y="397.5"/> <port id="pr_3120bb93-72be-4602-9e14-8fe6a13b6eb5_p1" x="3295.0" y="402.5"/> <port id="pr_3120bb93-72be-4602-9e14-8fe6a13b6eb5_p2" x="3265.0" y="402.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_be0d4fa3-b92d-4b7d-9558-f26550abf910"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15721744 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3788.25" y="186.33"/> <port id="pr_be0d4fa3-b92d-4b7d-9558-f26550abf910_p1" x="3778.25" y="191.33"/> <port id="pr_be0d4fa3-b92d-4b7d-9558-f26550abf910_p2" x="3808.25" y="191.33"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_88255672-2d27-49d1-997b-aa3b78be4b78"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12376548 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3468.0" y="648.3077"/> <port id="pr_88255672-2d27-49d1-997b-aa3b78be4b78_p1" x="3488.0" y="653.3077"/> <port id="pr_88255672-2d27-49d1-997b-aa3b78be4b78_p2" x="3458.0" y="653.3077"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a136f306-25c6-4198-8af8-199c8c6a1861"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21893191 PMID:11756498 Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3230.0" y="755.0"/> <port id="pr_a136f306-25c6-4198-8af8-199c8c6a1861_p1" x="3220.0" y="760.0"/> <port id="pr_a136f306-25c6-4198-8af8-199c8c6a1861_p2" x="3250.0" y="760.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_da7e9ae9-ec33-4e54-b678-d70461e35769"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17488777 NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death. References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3857.5" y="475.0"/> <port id="pr_da7e9ae9-ec33-4e54-b678-d70461e35769_p1" x="3847.5" y="480.0"/> <port id="pr_da7e9ae9-ec33-4e54-b678-d70461e35769_p2" x="3877.5" y="480.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4698d8a4-125e-487f-8602-1867faacac6c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11756498 Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3162.0" y="925.0"/> <port id="pr_4698d8a4-125e-487f-8602-1867faacac6c_p1" x="3152.0" y="930.0"/> <port id="pr_4698d8a4-125e-487f-8602-1867faacac6c_p2" x="3182.0" y="930.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dbc431c4-d20e-4369-852e-72298a074faf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16252010 NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation. PMID:16630834 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3995.0" y="283.125"/> <port id="pr_dbc431c4-d20e-4369-852e-72298a074faf_p1" x="3985.0" y="288.125"/> <port id="pr_dbc431c4-d20e-4369-852e-72298a074faf_p2" x="4015.0" y="288.125"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_206756e3-20ed-43d8-b42e-67de6c3a23a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16252010 NRIF undergoes K63 polyubiquitination, associates with TRAF6 and p62, and translocates to the nucleus References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4115.0" y="575.0"/> <port id="pr_206756e3-20ed-43d8-b42e-67de6c3a23a1_p1" x="4135.0" y="580.0"/> <port id="pr_206756e3-20ed-43d8-b42e-67de6c3a23a1_p2" x="4105.0" y="580.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_03c7bc19-88f6-446c-81bd-368e6359cd1b"> <bbox w="10.0" h="10.0" x="4035.0" y="693.25"/> <port id="pr_03c7bc19-88f6-446c-81bd-368e6359cd1b_p1" x="4040.0" y="683.25"/> <port id="pr_03c7bc19-88f6-446c-81bd-368e6359cd1b_p2" x="4040.0" y="713.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b2c02c42-3162-44be-9779-cc6a00ec9951"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16252010 activating the receptor causes NRIF to enter the nucleus and regulate the expression of genes that regulate neuronal survival/apoptosis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5915.0" y="4141.25"/> <port id="pr_b2c02c42-3162-44be-9779-cc6a00ec9951_p1" x="5920.0" y="4131.25"/> <port id="pr_b2c02c42-3162-44be-9779-cc6a00ec9951_p2" x="5920.0" y="4161.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2a7be8e5-2f86-4948-8a95-b477af3e5c19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10764727 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3750.974" y="815.2844"/> <port id="pr_2a7be8e5-2f86-4948-8a95-b477af3e5c19_p1" x="3740.974" y="820.2844"/> <port id="pr_2a7be8e5-2f86-4948-8a95-b477af3e5c19_p2" x="3770.974" y="820.2844"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f229d6c9-91b0-4acc-9845-fcd26387c046"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10764727 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3740.0" y="885.0"/> <port id="pr_f229d6c9-91b0-4acc-9845-fcd26387c046_p1" x="3730.0" y="890.0"/> <port id="pr_f229d6c9-91b0-4acc-9845-fcd26387c046_p2" x="3760.0" y="890.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2398e255-feee-4947-928f-2c95404324c2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11278287 14-3-3ε plays an important role in the modulation of nerve growth factor-dependent p75NTR/NADE-mediated apoptosis by binding zith NADE References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3745.0" y="559.5"/> <port id="pr_2398e255-feee-4947-928f-2c95404324c2_p1" x="3750.0" y="549.5"/> <port id="pr_2398e255-feee-4947-928f-2c95404324c2_p2" x="3750.0" y="579.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5d4f1789-b6df-4601-8eb7-995d4e45fc05"> <bbox w="10.0" h="10.0" x="2966.5" y="635.1129"/> <port id="pr_5d4f1789-b6df-4601-8eb7-995d4e45fc05_p1" x="2956.5" y="640.1129"/> <port id="pr_5d4f1789-b6df-4601-8eb7-995d4e45fc05_p2" x="2986.5" y="640.1129"/> </glyph> <glyph class="process" orientation="vertical" id="pr_64a29998-c407-4d52-90c0-9f61a24dc4af"> <bbox w="10.0" h="10.0" x="3102.25" y="687.0"/> <port id="pr_64a29998-c407-4d52-90c0-9f61a24dc4af_p1" x="3107.25" y="677.0"/> <port id="pr_64a29998-c407-4d52-90c0-9f61a24dc4af_p2" x="3107.25" y="707.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1d602fe8-6364-4f08-81c4-489c7e653ed8"> <bbox w="10.0" h="10.0" x="4355.0" y="2253.5"/> <port id="pr_1d602fe8-6364-4f08-81c4-489c7e653ed8_p1" x="4360.0" y="2243.5"/> <port id="pr_1d602fe8-6364-4f08-81c4-489c7e653ed8_p2" x="4360.0" y="2273.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_691ade83-4f7a-45d0-aa7f-9e7be050a0cf"> <bbox w="10.0" h="10.0" x="5986.25" y="4672.5"/> <port id="pr_691ade83-4f7a-45d0-aa7f-9e7be050a0cf_p1" x="5991.25" y="4662.5"/> <port id="pr_691ade83-4f7a-45d0-aa7f-9e7be050a0cf_p2" x="5991.25" y="4692.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_80f4baa1-7fb6-4f17-b65f-0f9a87ccfc23"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17496911 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="5038.0" y="1875.0"/> <port id="pr_80f4baa1-7fb6-4f17-b65f-0f9a87ccfc23_p1" x="5028.0" y="1880.0"/> <port id="pr_80f4baa1-7fb6-4f17-b65f-0f9a87ccfc23_p2" x="5058.0" y="1880.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f8605f44-3861-4259-9b9d-9853347f0da2"> <bbox w="10.0" h="10.0" x="4849.5" y="1757.0"/> <port id="pr_f8605f44-3861-4259-9b9d-9853347f0da2_p1" x="4839.5" y="1762.0"/> <port id="pr_f8605f44-3861-4259-9b9d-9853347f0da2_p2" x="4869.5" y="1762.0"/> </glyph> <glyph 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x="11597.5" y="2671.72"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3b4fafb8-d40a-4f31-b23f-1983a1882681"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18545270 Regulation of TNFR1 and CD95 signalling by receptor compartmentalization PMID:14744430 caspase-8 is polyubiquitylated at the DISC in response to Apo2L/TRAIL PMID:20531300 PMID:19427028 The ubiquitin-binding protein p62/sequestosome-1 promoted aggregation of CUL3-modified caspase-8 within p62-dependent foci, leading to full activation and processing of the enzyme and driving commitment to cell deathReferences_end References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="7498.5" y="953.6953"/> <port id="pr_3b4fafb8-d40a-4f31-b23f-1983a1882681_p1" x="7518.5" y="958.6953"/> <port id="pr_3b4fafb8-d40a-4f31-b23f-1983a1882681_p2" 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References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10475.375" y="2877.2915"/> <port id="pr_e5754ccc-80f1-473c-bc91-4f1f296fdace_p1" x="10495.375" y="2882.2915"/> <port id="pr_e5754ccc-80f1-473c-bc91-4f1f296fdace_p2" x="10465.375" y="2882.2915"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0f8c6730-e061-43f6-abda-8b521608d8d3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22441670 Cleavage of AMBRA1 by Capases PMID:23377657 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9847.875" y="2526.7915"/> <port id="pr_0f8c6730-e061-43f6-abda-8b521608d8d3_p1" x="9852.875" y="2516.7915"/> <port id="pr_0f8c6730-e061-43f6-abda-8b521608d8d3_p2" x="9852.875" y="2546.7915"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_81e772f9-18c9-40a8-a72c-8e67775b30dd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23377657 PMID:20724831 PMID:23991959 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="11341.285" y="2947.2568"/> <port id="pr_81e772f9-18c9-40a8-a72c-8e67775b30dd_p1" x="11331.285" y="2952.2568"/> <port id="pr_81e772f9-18c9-40a8-a72c-8e67775b30dd_p2" x="11361.285" y="2952.2568"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_a1904991-a6d9-4f09-80d5-d8c18f2a5c8b"> <bbox w="20.0" h="20.0" x="11004.11" y="3252.4287"/> <port id="logicglyph_a1904991-a6d9-4f09-80d5-d8c18f2a5c8b_p1" x="10994.11" y="3262.4287"/> <port id="logicglyph_a1904991-a6d9-4f09-80d5-d8c18f2a5c8b_p2" x="11034.11" y="3262.4287"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d7f17731-215c-4187-ba4e-184cdbf6012a"> <bbox w="10.0" h="10.0" x="9244.035" y="3456.1787"/> <port id="pr_d7f17731-215c-4187-ba4e-184cdbf6012a_p1" x="9234.035" y="3461.1787"/> <port id="pr_d7f17731-215c-4187-ba4e-184cdbf6012a_p2" x="9264.035" y="3461.1787"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_08a32e15-f635-42cf-a98e-f6fbe4b3503b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23242420 Calcium induced calpain-mediated Bax and Atg5 cleavage resulted in the collapse of the mitochondrial membrane potential and cytochrome c release References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="4477.3105" y="5744.0605"/> <port id="pr_08a32e15-f635-42cf-a98e-f6fbe4b3503b_p1" x="4467.3105" y="5749.0605"/> <port id="pr_08a32e15-f635-42cf-a98e-f6fbe4b3503b_p2" x="4497.3105" y="5749.0605"/> </glyph> <glyph class="process" orientation="horizontal" 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id="pr_10eb4dde-f135-42cb-a105-e90e7349a0d4"> <bbox w="10.0" h="10.0" x="10516.0" y="3312.625"/> <port id="pr_10eb4dde-f135-42cb-a105-e90e7349a0d4_p1" x="10506.0" y="3317.625"/> <port id="pr_10eb4dde-f135-42cb-a105-e90e7349a0d4_p2" x="10536.0" y="3317.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_760f248d-7537-41d4-8228-5cf6d4791140"> <bbox w="10.0" h="10.0" x="10516.0" y="3367.875"/> <port id="pr_760f248d-7537-41d4-8228-5cf6d4791140_p1" x="10536.0" y="3372.875"/> <port id="pr_760f248d-7537-41d4-8228-5cf6d4791140_p2" x="10506.0" y="3372.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fbe07ca1-b318-46a7-819d-9aee3831e554"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18612260 PMID:16143105 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10686.686" y="3304.5"/> <port id="pr_fbe07ca1-b318-46a7-819d-9aee3831e554_p1" x="10691.686" y="3294.5"/> <port id="pr_fbe07ca1-b318-46a7-819d-9aee3831e554_p2" x="10691.686" y="3324.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d73f97a7-6b97-4863-b3ae-0e452a2665d0"> <bbox w="10.0" h="10.0" x="7255.574" y="3449.0"/> <port id="pr_d73f97a7-6b97-4863-b3ae-0e452a2665d0_p1" x="7245.574" y="3454.0"/> <port id="pr_d73f97a7-6b97-4863-b3ae-0e452a2665d0_p2" x="7275.574" y="3454.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_714bc9aa-3c79-44e9-8cf0-101b73f01897"> <bbox w="10.0" h="10.0" x="10708.5" y="3610.4712"/> <port id="pr_714bc9aa-3c79-44e9-8cf0-101b73f01897_p1" x="10698.5" y="3615.4712"/> <port id="pr_714bc9aa-3c79-44e9-8cf0-101b73f01897_p2" x="10728.5" y="3615.4712"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3eb63a3a-4bba-4716-9b88-63364a4fd5f9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23774579 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10785.75" y="3568.0"/> <port id="pr_3eb63a3a-4bba-4716-9b88-63364a4fd5f9_p1" x="10790.75" y="3558.0"/> <port id="pr_3eb63a3a-4bba-4716-9b88-63364a4fd5f9_p2" x="10790.75" y="3588.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ece5b05b-9486-4255-b335-a28028ce6382"> <bbox w="10.0" h="10.0" x="10526.098" y="2328.5"/> <port id="pr_ece5b05b-9486-4255-b335-a28028ce6382_p1" x="10531.098" y="2348.5"/> <port id="pr_ece5b05b-9486-4255-b335-a28028ce6382_p2" x="10531.098" y="2318.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_401508b1-07b4-4ccd-a8a3-8be0d12fc4d2"> <bbox w="10.0" h="10.0" x="2245.5" y="987.0"/> <port id="pr_401508b1-07b4-4ccd-a8a3-8be0d12fc4d2_p1" x="2250.5" y="1007.0"/> <port id="pr_401508b1-07b4-4ccd-a8a3-8be0d12fc4d2_p2" x="2250.5" y="977.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_95387a8c-4e54-4e34-b0f6-4894d1322f68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23073834 PGAM5L/PGAM5S activate the mitochondrial fission regulator Drp1 by dephosphorylation, thus leading to mitochondrial fission. PMID:22265414 PGAM5S recruited the mitochondrial fission factor Drp1 and activated its GTPase activity by dephosphorylating the serine 637 site of Drp1 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10090.78" y="3541.625"/> <port id="pr_95387a8c-4e54-4e34-b0f6-4894d1322f68_p1" x="10095.78" y="3531.625"/> <port id="pr_95387a8c-4e54-4e34-b0f6-4894d1322f68_p2" x="10095.78" y="3561.625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fa4797c6-3e39-41c0-97bf-cae1cc51fcb4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:23073834 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10091.561" y="3647.0"/> <port id="pr_fa4797c6-3e39-41c0-97bf-cae1cc51fcb4_p1" x="10096.561" y="3637.0"/> <port id="pr_fa4797c6-3e39-41c0-97bf-cae1cc51fcb4_p2" x="10096.561" y="3667.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9d4de00c-def4-441f-911a-347ad0514df8"> <bbox w="10.0" h="10.0" x="10070.78" y="3541.625"/> <port id="pr_9d4de00c-def4-441f-911a-347ad0514df8_p1" x="10075.78" y="3561.625"/> <port id="pr_9d4de00c-def4-441f-911a-347ad0514df8_p2" x="10075.78" y="3531.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1f1950c7-ffca-497e-a441-68acf98e0b14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19942859 Lipolityc signal induce PKA activation that leads to AMPK activation and so lipid resynthesis References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="9715.502" y="3590.333"/> <port id="pr_1f1950c7-ffca-497e-a441-68acf98e0b14_p1" x="9705.502" y="3595.333"/> <port id="pr_1f1950c7-ffca-497e-a441-68acf98e0b14_p2" x="9735.502" y="3595.333"/> </glyph> 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thus inhibited References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="10493.375" y="3006.5415"/> <port id="pr_ad651164-c75f-423e-91c3-2fcdfda21af4_p1" x="10498.375" y="2996.5415"/> <port id="pr_ad651164-c75f-423e-91c3-2fcdfda21af4_p2" x="10498.375" y="3026.5415"/> </glyph> <glyph class="process" orientation="vertical" id="pr_06ebb9f0-5750-4387-8aac-0b1a5decf93c"> <bbox w="10.0" h="10.0" x="814.72595" y="3124.75"/> <port id="pr_06ebb9f0-5750-4387-8aac-0b1a5decf93c_p1" x="819.72595" y="3114.75"/> <port id="pr_06ebb9f0-5750-4387-8aac-0b1a5decf93c_p2" x="819.72595" y="3144.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a3112788-f364-41a6-ab67-5637c5dbec32"> <bbox w="10.0" h="10.0" x="10676.728" y="3492.5"/> <port id="pr_a3112788-f364-41a6-ab67-5637c5dbec32_p1" x="10696.728" y="3497.5"/> <port id="pr_a3112788-f364-41a6-ab67-5637c5dbec32_p2" x="10666.728" y="3497.5"/> </glyph> <glyph class="process" orientation="vertical" 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y="3592.3818"/> <port id="pr_fbfe6fd9-4bc8-4c37-9732-1fae1f4eb00b_p1" x="9315.543" y="3582.3818"/> <port id="pr_fbfe6fd9-4bc8-4c37-9732-1fae1f4eb00b_p2" x="9315.543" y="3612.3818"/> </glyph> <glyph class="process" orientation="vertical" id="pr_06fac7ed-22a0-4f73-801f-49b94fdcdf8b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21179058 PMID:23846383 References_end </body> </html> </notes> <bbox w="10.0" h="10.0" x="3645.0" y="6150.0"/> <port id="pr_06fac7ed-22a0-4f73-801f-49b94fdcdf8b_p1" x="3650.0" y="6140.0"/> <port id="pr_06fac7ed-22a0-4f73-801f-49b94fdcdf8b_p2" x="3650.0" y="6170.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6c0854b9-cb50-4e59-bd45-872a7a879af2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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<body>References_begin: PMID:28552631 PMID:27646922 Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis. 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