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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate CAS:N/A PUBCHEM:7726, CHEBI:18348, KEGGCOMPOUND:C04637</body> </html> </notes> <label text="PI4,5-P2"/> <bbox w="70.0" h="25.0" x="1637.5" y="438.0"/> </glyph> <glyph class="macromolecule" id="s157_sa5" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:ACTA1, HUGO:ACTA2, HUGO:ACTB, HUGO:ACTC1, HUGO:ACTG1, HUGO:ACTG2 Identifiers_end</body> </html> </notes> <label text="Actin fibers*"/> <bbox w="80.0" h="40.0" x="2024.5" y="256.5"/> </glyph> <glyph class="macromolecule" id="s109_sa7" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:EZR Ezrin</body> </html> </notes> <label text="EZR"/> <bbox w="80.0" h="40.0" x="1840.9615" y="264.19232"/> <glyph class="state variable" id="_b8e398dc-023f-457b-a386-0da9ac9bbacb"> <state value="" variable="Thr 567"/> <bbox w="45.0" h="10.0" x="1875.4109" y="259.19232"/> </glyph> </glyph> <glyph class="phenotype" id="s160_sa11" compartmentRef="c1_ca1"> <label text="Cell-cell adhesions"/> <bbox w="147.0" h="42.0" x="2182.5" y="65.5"/> </glyph> <glyph class="phenotype" id="s194_sa13" compartmentRef="c1_ca1"> <label text="Metastasis"/> <bbox w="80.0" h="30.0" x="2106.5" y="707.5"/> </glyph> <glyph class="phenotype" id="s193_sa14" compartmentRef="c1_ca1"> <label text="Stress-induced apoptosis resistance"/> <bbox w="239.0" h="43.0" x="1808.5" y="652.5"/> </glyph> <glyph class="phenotype" id="s162_sa15" compartmentRef="c1_ca1"> <label text="Cytoskeleton remodeling"/> <bbox w="171.0" h="49.0" x="2820.5" y="256.5"/> </glyph> <glyph class="phenotype" id="s178_sa229"> <label text="Cell-matrix adhesions"/> <bbox 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</notes> <label text="FOXO*"/> <bbox w="80.0" h="40.0" x="1822.375" y="974.625"/> <glyph class="state variable" id="_3500b782-ba37-40df-9040-6f96935e4141"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1871.4436" y="969.625"/> </glyph> </glyph> <glyph class="macromolecule" id="s105_sa29" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>BCAR1, Cas family scaffolding protein HUGO:BCAR1</body> </html> </notes> <label text="p130Cas*"/> <bbox w="80.0" h="40.0" x="3251.3057" y="718.80554"/> <glyph class="state variable" id="_8c329b01-d187-4cf6-b400-9b3128dea66e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3300.3743" y="713.80554"/> </glyph> </glyph> <glyph class="macromolecule" id="s43_sa32" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:GSK3A glycogen synthase kinase 3 alpha HUGO:GSK3B glycogen synthase kinase 3 beta</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="1405.0" y="959.0"/> <glyph class="state variable" id="_67d5236e-cc93-46c1-aa11-f125d51183d5"> <state value="P" variable="Ser9"/> <bbox w="35.0" h="10.0" x="1467.5" y="982.29565"/> </glyph> </glyph> <glyph class="macromolecule" id="s20_sa33" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:MDM2 Mdm2 p53 binding protein homolog (mouse)</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="2915.5" y="1064.5"/> <glyph class="state variable" id="_493b99b5-24c3-427e-891f-b40ccaaae77d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2964.5686" y="1059.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s19_sa34" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:MDM2 Mdm2 p53 binding protein homolog (mouse)</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="2773.0" y="1064.0"/> <glyph class="state variable" id="_1c529543-40d5-4b65-8bfc-df252f21ed78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2824.5686" y="1059.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s123_sa38" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Cytosolic retention ----- content merged by Celldesigner to SBGN-ML translation ------ HUGO:CDKN1A cyclin dependent kinase inhibitor 1A</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="1894.375" y="1071.125"/> <glyph class="state variable" id="_e7949591-9bbe-4a87-8b9c-5f9692a37ad7"> <state value="P" 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y="793.0"/> <glyph class="state variable" id="_27a12818-b8d9-41b8-8565-3d31c5b7e08c"> <state value="" variable="Y527"/> <bbox w="30.0" h="10.0" x="3412.9492" y="788.0"/> </glyph> </glyph> <glyph class="phenotype" id="s290_sa42" compartmentRef="c1_ca1"> <label text="Adherens junctions"/> <bbox w="123.0" h="42.0" x="1209.75" y="1195.25"/> </glyph> <glyph class="macromolecule" id="s64_sa45" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TP53 tumor protein p53</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="3000.0" y="1143.5"/> <glyph class="state variable" id="_1d7dad26-a87f-4e5f-9158-8f2f93f7bd56"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="3046.5686" y="1138.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s53_sa46" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 HUGO:SRC</body> </html> </notes> <label text="Src"/> <bbox w="80.0" h="40.0" x="3721.0" y="806.0"/> <glyph class="state variable" id="_6443c141-e7ee-4b28-8a15-e9b8973ea0e9"> <state value="" variable="Tyr416"/> <bbox w="40.0" h="10.0" x="3740.9045" y="841.0"/> </glyph> <glyph class="state variable" id="_33db38c0-6ec1-4765-ab8b-e5106b013252"> <state value="P" variable="Tyr527"/> <bbox w="45.0" h="10.0" x="3778.5" y="829.29565"/> </glyph> </glyph> <glyph class="macromolecule" id="s50_sa47" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>c-src tyrosine kinase HUGO:CSK</body> </html> </notes> <label text="Csk"/> <bbox w="80.0" h="40.0" x="3077.0" y="1423.0"/> </glyph> <glyph class="macromolecule" id="s24_sa48" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 HUGO:SRC</body> </html> </notes> <label text="Src"/> <bbox w="80.0" h="40.0" x="3530.0" y="789.0"/> <glyph class="state variable" id="_fc79a7b9-d40e-4d8d-bd23-0fdee09108ad"> <state value="" variable="Tyr416"/> <bbox w="40.0" h="10.0" x="3549.9045" y="824.0"/> </glyph> <glyph class="state variable" id="_dedd4574-8c2a-4ca8-8528-07304e04f7e5"> <state value="" variable="Tyr527"/> <bbox w="40.0" h="10.0" x="3590.0" y="812.29565"/> </glyph> </glyph> <glyph class="macromolecule" id="s314_sa49" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RCHY1 ring finger and CHY zinc finger domain containing 1</body> </html> </notes> <label text="PIRH2*"/> <bbox w="80.0" h="40.0" x="3125.125" y="1276.875"/> </glyph> <glyph class="macromolecule" id="s306_sa50" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CTNNB1 catenin beta 1</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="728.0" y="1331.0"/> </glyph> <glyph class="macromolecule" id="s298_sa52" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:VIM Vimentin</body> </html> </notes> <label text="Vimentin*"/> <bbox w="80.0" h="40.0" x="944.0" y="1329.0"/> </glyph> <glyph class="macromolecule" id="s73_sa53" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CDH1 cadherin 1, type 1, E-cadherin (epithelial)</body> </html> </notes> <label text="E-cadherin*"/> <bbox w="80.0" h="40.0" x="1349.0" y="1333.0"/> </glyph> <glyph class="macromolecule" id="s72_sa54" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO: catenin (cadherin-associated protein), delta 1 ----- content merged by Celldesigner to SBGN-ML translation ------ HUGO:CTNND1 catenin (cadherin-associated protein), delta 1</body> </html> </notes> <label text="γ-catenin*"/> <bbox w="80.0" h="40.0" x="1231.0" y="1333.0"/> </glyph> <glyph class="macromolecule" id="s71_sa55" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:ITGB3 integrin subunit beta 3</body> </html> </notes> <label text="ITGB3"/> <bbox w="80.0" h="40.0" x="1087.0" y="1333.0"/> </glyph> <glyph class="nucleic acid feature" id="s51_sa56" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>c-src tyrosine kinase HUGO:CSK</body> </html> </notes> <label text="Csk"/> <bbox w="90.0" h="25.0" x="3062.0" y="1537.5"/> <glyph class="unit of information" id="_cc8f408a-25d1-47ae-89e1-9499485d7f4d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3097.0" y="1532.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s52_sa57" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>eukaryotic translation initiation factor 2 subunit alpha HUGO:EIF2S1 eukaryotic translation initiation factor 2 subunit beta HUGO:EIF2S2 eukaryotic translation initiation factor 2 subunit gamma HUGO:EIF2S3</body> </html> </notes> <label text="eIF2*"/> <bbox w="80.0" h="40.0" x="3824.0" y="791.0"/> <glyph class="state variable" id="_98cdeb50-c888-476d-82a0-ddc441834988"> <state value="P" variable="Ser51"/> <bbox w="40.0" h="10.0" x="3860.9492" y="786.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s311_sa60" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>early growth response 1 HUGO:EGR1</body> </html> </notes> <label text="EGR1"/> <bbox w="80.0" h="40.0" x="2814.125" y="1422.875"/> </glyph> <glyph class="macromolecule" id="s49_sa62" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>eukaryotic translation initiation factor 2 subunit alpha HUGO:EIF2S1 eukaryotic translation initiation factor 2 subunit beta HUGO:EIF2S2 eukaryotic translation initiation factor 2 subunit gamma HUGO:EIF2S3</body> </html> </notes> <label text="eIF2*"/> <bbox w="80.0" h="40.0" x="3734.5" y="996.5"/> <glyph class="state variable" id="_41c3e153-6d92-4ae1-b911-57ba2e37b0fa"> <state value="" variable="Ser51"/> <bbox w="35.0" h="10.0" x="3773.9492" y="991.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s313_sa64" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RCHY1 ring finger and CHY zinc finger domain containing 1</body> </html> </notes> <label text="PIRH2*"/> <bbox w="90.0" h="25.0" x="2954.125" y="1432.375"/> <glyph class="unit of information" id="_1c4ffdfb-a765-4270-8f81-66658a172198"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2989.125" y="1427.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s168_sa65" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:ACTA1, HUGO:ACTA2, HUGO:ACTB, HUGO:ACTC1, HUGO:ACTG1, HUGO:ACTG2 Identifiers_end</body> </html> </notes> <label text="Actin cytoskeletal*"/> <bbox w="162.0" h="37.0" x="4935.0" y="561.0"/> </glyph> <glyph class="macromolecule" id="s164_sa66" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Profilin 1 HUGO:PFN1</body> </html> </notes> <label text="Profilin*"/> <bbox w="80.0" h="40.0" x="4837.0" y="396.0"/> </glyph> <glyph class="phenotype" id="s124_sa71" compartmentRef="c2_ca2"> <label text="G1 Cell cycle arrest"/> <bbox w="80.0" h="30.0" x="1819.5" y="1426.0"/> </glyph> <glyph class="macromolecule" id="s99_sa72" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>FK506 binding protein 8 HUGO:FKBP8</body> </html> </notes> <label text="FKBP38*"/> <bbox w="80.0" h="44.0" x="1608.0" y="114.0"/> </glyph> <glyph class="macromolecule" id="s70_sa74" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>poly(rC) binding protein 1 HUGO:PCBP1</body> </html> </notes> <label text="PCBP1"/> <bbox w="80.0" h="40.0" x="4338.0" y="1487.0"/> </glyph> <glyph class="nucleic acid feature" id="s310_sa75" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>early growth response 1 HUGO:EGR1</body> </html> </notes> <label text="EGR1"/> <bbox w="90.0" h="25.0" x="2779.125" y="1514.375"/> <glyph class="unit of information" id="_dd9b0536-35a6-448a-956c-38aeeaa3aa9d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2814.125" y="1509.375"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s305_sa76" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CTNNB1 catenin beta 1</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="90.0" h="25.0" x="694.0" y="1439.5"/> <glyph class="unit of information" id="_9817fc65-9f44-4735-a163-1dc66d3b6816"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="729.0" y="1434.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s302_sa77" compartmentRef="c2_ca2"> <label text="Cytokeratin*"/> <bbox w="90.0" h="25.0" x="800.0" y="1439.5"/> <glyph class="unit of information" id="_77f7b58c-4a7b-49bb-b234-92cb5ede88ed"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="835.0" y="1434.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s296_sa78" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:VIM Vimentin</body> </html> </notes> <label text="Vimentin*"/> <bbox w="90.0" h="25.0" x="910.0" y="1439.5"/> <glyph class="unit of information" id="_432e4a2e-4499-42c1-ba70-7c554e01c14d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="945.0" y="1434.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s141_sa79" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Examples of target genes : Raf1, Map4k4, Bicc1, Mapk10 (JNK3), Txnl2, Azi2, Tera, Sema3a, Lrp4, Actc1, Myl3, Hspg2, Pgm2, Hif3a, Asb5, E2f5, Npm1, Cenpb, Rbbp6,Scyl1,</body> </html> </notes> <label text="target genes*"/> <bbox w="134.0" h="24.0" x="2467.0" y="1821.0"/> <glyph class="unit of information" id="_c74b9e4e-c454-4777-8112-6bbb2c2a80b1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2524.0" y="1816.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s140_sa80" compartmentRef="c2_ca2"> <label text="target genes*"/> <bbox w="97.0" h="25.0" x="2461.0" y="1740.0"/> </glyph> <glyph class="source and sink" id="s98_sa81" compartmentRef="c3_ca3"> <label text="sa80_degraded"/> <bbox w="30.0" h="30.0" x="1617.4773" y="234.81818"/> </glyph> <glyph class="nucleic acid feature" id="s59_sa82" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTP4A3 protein tyrosine phosphatase type IVA, member 3</body> </html> </notes> <label text="PTP4A3"/> <bbox w="90.0" h="25.0" x="4002.0" y="1434.5"/> <glyph class="unit of information" id="_eb1ccb9e-8ded-4e0d-a68a-dd66dd7d8ebf"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4037.0" y="1429.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s58_sa83" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:ITGB3 integrin subunit beta 3</body> </html> </notes> <label text="ITGB3"/> <bbox w="90.0" h="25.0" x="1054.5" y="1440.5"/> <glyph class="unit of information" id="_1aeca73a-e2ae-40c6-96c3-a102f73cc804"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1089.5" y="1435.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s56_sa84" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CTNND1 catenin (cadherin-associated protein), delta 1</body> </html> </notes> <label text="γ-catenin*"/> <bbox w="90.0" h="25.0" x="1199.0" y="1442.5"/> <glyph class="unit of information" id="_c2689899-4b20-49f7-b007-963f6fa121be"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1234.0" y="1437.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s48_sa85" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CDH1 cadherin 1, type 1, E-cadherin (epithelial)</body> </html> </notes> <label text="E-cadherin*"/> <bbox w="90.0" h="25.0" x="1316.0" y="1442.5"/> <glyph class="unit of information" id="_736689f8-319f-444b-8b87-66100df8a23c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1351.0" y="1437.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s312_sa87" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RCHY1 ring finger and CHY zinc finger domain containing 1</body> </html> </notes> <label text="PIRH2*"/> <bbox w="70.0" h="25.0" x="2914.125" y="1531.375"/> </glyph> <glyph class="nucleic acid feature" id="s228_sa88" compartmentRef="c2_ca2"> <label text="MIR495"/> <bbox w="70.0" h="25.0" x="4289.0" y="1564.5"/> </glyph> <glyph class="nucleic acid feature" id="s226_sa89" compartmentRef="c2_ca2"> <label text="MIR495"/> <bbox w="90.0" h="25.0" x="4090.0" y="1562.5"/> <glyph class="unit of information" id="_8443fc34-ddfc-4622-baa5-d153eeac4de4"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4120.0" y="1557.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s309_sa90" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>early growth response 1 HUGO:EGR1</body> </html> </notes> <label text="EGR1"/> <bbox w="70.0" h="25.0" x="2775.125" y="1608.375"/> </glyph> <glyph class="nucleic acid feature" id="s304_sa91" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CTNNB1 catenin beta 1</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="70.0" h="25.0" x="692.0" y="1539.5"/> </glyph> <glyph class="nucleic acid feature" id="s300_sa92" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Cytokeratin*</body> </html> </notes> <label text="KRT*"/> <bbox w="70.0" h="25.0" x="798.0" y="1539.5"/> </glyph> <glyph class="nucleic acid feature" id="s295_sa93" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:VIM Vimentin</body> </html> </notes> <label text="Vimentin*"/> <bbox w="70.0" h="25.0" x="908.0" y="1539.5"/> </glyph> <glyph class="nucleic acid feature" id="s227_sa94" compartmentRef="c2_ca2"> <label text="MIR551A"/> <bbox w="90.0" h="25.0" x="4092.0" y="1471.5"/> <glyph class="unit of information" id="_17ef83b2-09de-4a5d-95eb-5604613c4692"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4122.0" y="1466.5"/> </glyph> </glyph> <glyph class="phenotype" id="s173_sa95" compartmentRef="c1_ca1"> <label text="Actin polymerisation"/> <bbox w="135.0" h="36.0" x="4213.0" y="1045.0"/> </glyph> <glyph class="macromolecule" id="s121_sa96" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="1894.5" y="1513.0"/> </glyph> <glyph class="nucleic acid feature" id="s57_sa98" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:ITGB3 integrin subunit beta 3</body> </html> </notes> <label text="ITGB3"/> <bbox w="70.0" h="25.0" x="1051.5" y="1541.5"/> </glyph> <glyph class="nucleic acid feature" id="s54_sa99" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CTNND1 catenin (cadherin-associated protein), delta 1</body> </html> </notes> <label text="γ-catenin*"/> <bbox w="70.0" h="25.0" x="1194.0" y="1549.5"/> </glyph> <glyph class="nucleic acid feature" id="s47_sa100" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CDH1 cadherin 1, type 1, E-cadherin (epithelial)</body> </html> </notes> <label text="E-cadherin*"/> <bbox w="70.0" h="25.0" x="1312.0" y="1549.5"/> </glyph> <glyph class="nucleic acid feature" id="s23_sa101" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTP4A3 protein tyrosine phosphatase type IVA, member 3</body> </html> </notes> <label text="PTP4A3"/> <bbox w="70.0" h="25.0" x="4004.0" y="1550.5"/> </glyph> <glyph class="nucleic acid feature" id="s231_sa102" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>PMID:25475733</body> </html> </notes> <label text="CpG Island MIR495 promoter*"/> <bbox w="179.0" h="27.0" x="4258.0" y="1610.5"/> <glyph class="state variable" id="_167276dd-8f76-4fb6-86a8-9deb4fe5d9d6"> <state value="Me" variable=""/> <bbox w="20.0" h="10.0" x="4291.1704" y="1605.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s120_sa103" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="90.0" h="25.0" x="1882.0" y="1642.5"/> <glyph class="unit of information" id="_b3f7217c-24ab-46ca-bc7e-1a7083809ff4"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1917.0" y="1637.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s117_sa104" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CDKN1A cyclin dependent kinase inhibitor 1A</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="90.0" h="25.0" x="1767.0" y="1656.5"/> <glyph class="unit of information" id="_971be351-504c-42d9-8293-4ba64b2f7c29"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1802.0" y="1651.5"/> </glyph> </glyph> <glyph class="phenotype" id="s111_sa105" compartmentRef="c2_ca2"> <label text="DNA damage"/> <bbox w="80.0" h="30.0" x="2222.125" y="1672.875"/> </glyph> <glyph class="simple chemical" id="s235_sa110" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>PMID:25475733</body> </html> </notes> <label text="5-Aza-dC*"/> <bbox w="80.0" h="30.0" x="3983.0" y="1624.0"/> <glyph class="unit of information" id="_e86a9b12-b4d6-4aa7-8614-1ebac4006626"> <label text="drug"/> <bbox w="25.0" h="10.0" x="4010.5" y="1619.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s233_sa111" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>PMID:25475733 ----- content merged by Celldesigner to SBGN-ML translation ------ DNA methyltransferase 1 HUGO:DMNT1</body> </html> </notes> <label text="DNMT*"/> <bbox w="80.0" h="40.0" x="4083.0" y="1623.0"/> </glyph> <glyph class="nucleic acid feature" id="s232_sa112" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>PMID:25475733</body> </html> </notes> <label text="CpG Island MIR495 promoter*"/> <bbox w="185.0" h="26.0" x="4271.375" y="1672.125"/> <glyph class="state variable" id="_48493726-df26-4593-98fb-7123f39d63b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4310.9927" y="1667.125"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s119_sa113" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="70.0" h="25.0" x="1884.0" y="1740.5"/> </glyph> <glyph class="nucleic acid feature" id="s116_sa114" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CDKN1A cyclin dependent kinase inhibitor 1A</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="70.0" h="25.0" x="1766.0" y="1754.5"/> </glyph> <glyph class="phenotype" id="s429_sa117"> <label text="Escape to immune response"/> <bbox w="150.0" h="25.0" x="5290.0" y="1102.0"/> </glyph> <glyph class="macromolecule" id="s425_sa118" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein family D (Hsp60) member 1 HUGO:HSPD1</body> </html> </notes> <label text="HSP60*"/> <bbox w="80.0" h="40.0" x="4559.0" y="1015.0"/> <glyph class="state variable" id="_5cd20d76-e7a1-46ad-9467-99398dbe04a9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4610.5684" y="1010.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s395_sa119" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>UL16 binding protein 2 HUGO:ULBP2</body> </html> </notes> <label text="ULBP2"/> <bbox w="90.0" h="25.0" x="4355.0" y="2114.5"/> <glyph class="unit of information" id="_26dd5525-fb2b-4164-b2b6-c0e9a5e990b6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4390.0" y="2109.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s394_sa120" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>UL16 binding protein 2 HUGO:ULBP2</body> </html> </notes> <label text="ULBP2"/> <bbox w="70.0" h="25.0" x="4235.0" y="2114.5"/> </glyph> <glyph class="macromolecule" id="s221_sa121" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:SNAI1, HUGO:SNAI2, HUGO:SNAI3 Identifieres_end</body> </html> </notes> <label text="Snail*"/> <bbox w="80.0" h="40.0" x="1334.5" y="1682.0"/> <glyph class="state variable" id="_f779a5a2-c375-4323-b1fa-0b0e880a1fb8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1409.5" y="1705.2843"/> </glyph> </glyph> <glyph class="macromolecule" id="s46_sa122" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:SNAI1, HUGO:SNAI2, HUGO:SNAI3 Identifieres_end</body> </html> </notes> <label text="Snail*"/> <bbox w="80.0" h="40.0" x="1496.0" y="1678.0"/> <glyph class="state variable" id="_14ae67b4-b98e-4ef9-8eae-b9b09f9dd69c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1568.5" y="1701.2843"/> </glyph> </glyph> <glyph class="macromolecule" id="s398_sa127" compartmentRef="c6_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein family D (Hsp60) member 1 HUGO:HSPD1</body> </html> </notes> <label text="HSP60*"/> <bbox w="80.0" h="40.0" x="4969.0" y="1197.0"/> <glyph class="state variable" id="_a6bbba8a-70fe-4774-b6ec-f153a5e37d2e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5018.0684" y="1192.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s389_sa129" compartmentRef="c2_ca2"> <label text="PTP4A3 promoter biding site*"/> <bbox w="185.0" h="22.5" x="4296.5" y="1997.75"/> </glyph> <glyph class="nucleic acid feature" id="s188_sa130" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>There are 2 Smad binding element sites (SBE: E1 and E4) in PRL-3 promoter</body> </html> </notes> <label text="SBE promoter*"/> <bbox w="117.0" h="22.0" x="3568.5" y="1633.0"/> 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compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>myocyte enhancer factor 2C HUGO:MEF2C</body> </html> </notes> <label text="MEF2C"/> <bbox w="90.0" h="25.0" x="3639.0" y="1865.5"/> <glyph class="unit of information" id="_505b501b-406e-4fed-9735-1b509e4360ac"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3674.0" y="1860.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s385_sa135" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>myocyte enhancer factor 2C HUGO:MEF2C</body> </html> </notes> <label text="MEF2C"/> <bbox w="70.0" h="25.0" x="3779.0" y="1865.5"/> </glyph> <glyph class="macromolecule" id="s289_sa138" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>histone cluster 1 H3 family member a HUGO:HIST1H3A histone cluster 1 H3 family member b HUGO:HIST1H3B histone cluster 1 H3 family member c HUGO:HIST1H3C histone cluster 1 H3 family member d HUGO:HIST1H3D histone cluster 1 H3 family member e HUGO:HIST1H3E histone cluster 1 H3 family member f HUGO:HIST1H3F histone cluster 1 H3 family member g HUGO:HIST1H3G histone cluster 1 H3 family member h HUGO:HIST1H3H histone cluster 1 H3 family member i HUGO:HIST1H3I histone cluster 1 H3 family member j HUGO:HIST1H3J histone cluster 1 H3 pseudogene 1 HUGO:HIST1H3PS1</body> </html> </notes> <label text="Histone H3*"/> <bbox w="122.0" h="52.0" x="1452.053" y="2186.7727"/> <glyph class="state variable" id="_8a26532b-312a-4ca6-b0f9-6bca3c0f3ddc"> <state value="" variable="K9"/> <bbox w="20.0" h="10.0" x="1503.1016" y="2181.7727"/> </glyph> <glyph class="state variable" id="_3dcc772e-0b60-40e6-bb64-a8474b59076a"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1473.0354" y="2181.7727"/> </glyph> <glyph class="state variable" id="_9bf11cac-95f7-4d52-9ff9-68a8cd506c14"> <state value="" variable="K9"/> <bbox w="20.0" h="10.0" x="1528.9006" y="2181.7727"/> </glyph> </glyph> <glyph class="macromolecule" id="s288_sa139" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>histone cluster 1 H3 family member a HUGO:HIST1H3A histone cluster 1 H3 family member b HUGO:HIST1H3B histone cluster 1 H3 family member c HUGO:HIST1H3C histone cluster 1 H3 family member d HUGO:HIST1H3D histone cluster 1 H3 family member e HUGO:HIST1H3E histone cluster 1 H3 family member f HUGO:HIST1H3F histone cluster 1 H3 family member g HUGO:HIST1H3G histone cluster 1 H3 family member h HUGO:HIST1H3H histone cluster 1 H3 family member i HUGO:HIST1H3I histone cluster 1 H3 family member j HUGO:HIST1H3J histone cluster 1 H3 pseudogene 1 HUGO:HIST1H3PS1</body> </html> </notes> <label text="Histone H3*"/> <bbox w="122.0" h="52.0" x="1245.053" y="2154.7727"/> <glyph class="state variable" id="_c2f9cc8f-94f1-4110-a908-6e277b67b3af"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1291.1016" y="2149.7727"/> </glyph> <glyph class="state variable" id="_37fa96ee-7160-42b8-90fa-f01425d2b16d"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1266.0354" y="2149.7727"/> </glyph> <glyph class="state variable" id="_3800feae-1803-4a00-9c69-29cf09f3a4a4"> <state value="" variable="K9"/> <bbox w="20.0" h="10.0" x="1321.9006" y="2149.7727"/> </glyph> </glyph> <glyph class="macromolecule" id="s287_sa140" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>histone cluster 1 H3 family member a HUGO:HIST1H3A histone cluster 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y="2040.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s319_sa151" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>vascular endothelial growth factor A HUGO:VEGFA vascular endothelial growth factor B HUGO:VEGFB vascular endothelial growth factor C HUGO:VEGFC vascular endothelial growth factor D HUGO:VEGFD</body> </html> </notes> <label text="VEGF*"/> <bbox w="70.0" h="25.0" x="3469.0" y="2045.5"/> </glyph> <glyph class="nucleic acid feature" id="s259_sa154" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>paxillin HUGO:PXN</body> </html> </notes> <label text="PXN"/> <bbox w="70.0" h="25.0" x="2592.0" y="2079.5"/> </glyph> <glyph class="nucleic acid feature" id="s254_sa155" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>FBJ murine osteosarcoma viral oncogene homolog HUGO:FOS</body> </html> </notes> <label text="FOS"/> <bbox w="70.0" h="25.0" x="2372.0" y="2089.5"/> </glyph> <glyph class="nucleic acid feature" id="s250_sa156" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>TERF2 interacting protein HUGO:TERF2IP</body> </html> </notes> <label text="RAP1*"/> <bbox w="70.0" h="25.0" x="1019.625" y="1656.375"/> </glyph> <glyph class="nucleic acid feature" id="s212_sa157" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>potassium calcium-activated channel subfamily N member 4 HUGO:KCNN4</body> </html> </notes> <label text="KCNN4"/> <bbox 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metallopeptidase inhibitor 2 "tissue inhibitor of metalloproteinase 2" HUGO:TIMP2</body> </html> </notes> <label text="TIMP2"/> <bbox w="70.0" h="25.0" x="3397.0" y="2259.5"/> </glyph> <glyph class="nucleic acid feature" id="s371_sa162" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 2 HUGO:MMP2</body> </html> </notes> <label text="MMP2"/> <bbox w="90.0" h="25.0" x="3260.0" y="2359.5"/> <glyph class="unit of information" id="_982bbfb1-0061-4e44-9ffa-aefdd33c47cb"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3295.0" y="2354.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s370_sa163" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 2 HUGO:MMP2</body> </html> </notes> <label text="MMP2"/> <bbox w="70.0" h="25.0" x="3274.0" y="2259.5"/> </glyph> <glyph class="nucleic acid feature" id="s332_sa164" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) HUGO:ITGB1</body> </html> </notes> <label text="ITGB1"/> <bbox w="90.0" h="25.0" x="2265.0" y="1890.5"/> <glyph class="unit of information" id="_10503a16-9c29-44b8-bf8e-d07d75741ea9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2300.0" y="1885.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s331_sa165" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) HUGO:ITGB1</body> </html> 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text="Angiogenesis"/> <bbox w="100.0" h="35.0" x="5366.0" y="3108.5"/> </glyph> <glyph class="nucleic acid feature" id="s260_sa173" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>paxillin HUGO:PXN</body> </html> </notes> <label text="PXN"/> <bbox w="90.0" h="25.0" x="2572.0" y="2209.5"/> <glyph class="unit of information" id="_4d96df70-63bd-4b0a-8ce1-69cf1027d9ab"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2607.0" y="2204.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s258_sa174" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) CD49B HUGO:ITGA2</body> </html> </notes> <label text="ITGA2"/> <bbox w="90.0" h="25.0" x="2211.0" y="2332.5"/> <glyph class="unit of 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text="MIR21"/> <bbox w="70.0" h="25.0" x="4821.0" y="1867.5"/> </glyph> <glyph class="nucleic acid feature" id="s517_sa244" compartmentRef="c2_ca2"> <label text="MIR17"/> <bbox w="70.0" h="25.0" x="4621.0" y="1867.5"/> </glyph> <glyph class="nucleic acid feature" id="s518_sa245" compartmentRef="c2_ca2"> <label text="MIR17"/> <bbox w="90.0" h="25.0" x="4598.0" y="1788.5"/> <glyph class="unit of information" id="_14f1294d-0743-4fca-8dd6-93c4b8439ab7"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4628.0" y="1783.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s519_sa246" compartmentRef="c2_ca2"> <label text="MIR19A"/> <bbox w="90.0" h="25.0" x="4698.0" y="1788.5"/> <glyph class="unit of information" id="_03a4843c-4ebc-4f9c-8bd7-c5cbf83a6696"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4728.0" y="1783.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s520_sa247" compartmentRef="c2_ca2"> <label text="MIR21"/> <bbox w="90.0" h="25.0" x="4798.0" y="1788.5"/> <glyph class="unit of information" id="_7f187c63-5e56-4603-a66f-27db6cd12a8a"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4828.0" y="1783.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s521_sa248" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTEN phosphatase and tensin homolog</body> </html> </notes> <label text="PTEN"/> <bbox w="70.0" h="25.0" x="4772.0" y="1628.5"/> </glyph> <glyph class="nucleic acid feature" id="s522_sa249" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTEN phosphatase and tensin homolog</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="4793.0" y="1548.5"/> <glyph class="unit of information" id="_ca32e77e-43fa-41c4-b2a7-b5a219d45ede"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4828.0" y="1543.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s531_sa251" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>c-src tyrosine kinase HUGO:CSK</body> </html> </notes> <label text="Csk"/> <bbox w="70.0" h="25.0" x="3053.0" y="1612.5"/> </glyph> <glyph class="macromolecule" id="s533_sa253" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: ADP ribosylation factor like GTPase family HUGO:ARFGAP1, HUGO:ARFGAP2, HUGO:ARFGAP3 Identifiers_end</body> </html> </notes> <label text="ARF1_GAPs*"/> <bbox w="80.0" h="20.0" x="3668.0" y="3330.0"/> </glyph> <glyph class="macromolecule" id="s534_sa254" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ADP ribosylation factor guanine nucleotide exchange factor 1 HUGO:ARFGEF1 ADP ribosylation factor guanine nucleotide exchange factor 2 HUGO:ARFGEF2</body> </html> </notes> <label text="ARF1_GEFs*"/> <bbox w="80.0" h="20.0" x="3668.0" y="3200.0"/> </glyph> <glyph class="macromolecule" id="s546_sa256" compartmentRef="c1_ca1"> <label text="Ca2+_channel"/> <bbox w="130.0" h="40.0" x="613.0" y="61.0"/> <glyph class="unit of information" id="_fe2f0cf0-760a-412d-b918-43492111158c"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="648.0" y="56.0"/> </glyph> <glyph class="state variable" id="_cee8d852-dccc-4a3c-8801-d26505c263cb"> <state value="open" variable=""/> <bbox w="30.0" h="10.0" x="663.0" y="96.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s183_sa258" compartmentRef="c1_ca1"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="703.0" y="131.0"/> </glyph> <glyph class="macromolecule" id="s551_sa259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>calcium/calmodulin-dependent protein kinase II alpha HUGO:CAMK2A calcium/calmodulin-dependent protein kinase II beta HUGO:CAMK2B calcium/calmodulin-dependent protein kinase II delta HUGO:CAMK2D calcium/calmodulin-dependent protein kinase II gamma HUGO:CAMK2G</body> </html> </notes> <label text="CAMK2*"/> <bbox w="80.0" h="40.0" x="863.0" y="271.0"/> </glyph> <glyph class="macromolecule" id="s552_sa260" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>calmodulin 1 (phosphorylase kinase, delta) HUGO:CALM1 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="773.0" y="131.0"/> </glyph> <glyph class="nucleic acid feature" id="s560_sa261" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Stathmins family Stathmin 1 HUGO:STMN1 Stathmin 2 HUGO:STMN2 Stathmin 3 HUGO:STMN3 Stathmin 4 HUGO:STMN4</body> </html> </notes> <label text="Stathmin*"/> <bbox w="70.0" h="25.0" x="3718.0" y="2154.5"/> </glyph> <glyph class="nucleic acid feature" id="s561_sa262" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Stathmins family Stathmin 1 HUGO:STMN1 Stathmin 2 HUGO:STMN2 Stathmin 3 HUGO:STMN3 Stathmin 4 HUGO:STMN4</body> </html> </notes> <label text="Stathmin*"/> <bbox w="90.0" h="25.0" x="3707.0" y="2254.5"/> <glyph class="unit of information" id="_3b252dd3-2f73-48b2-a6b1-a9a0a34e4a5b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3742.0" y="2249.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s562_sa264" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Stathmins family Stathmin 1 HUGO:STMN1 Stathmin 2 HUGO:STMN2 Stathmin 3 HUGO:STMN3 Stathmin 4 HUGO:STMN4</body> </html> </notes> <label text="Stathmin*"/> <bbox w="80.0" h="40.0" x="3865.0" y="2734.0"/> <glyph class="state variable" id="_37cfe364-c867-45b2-b8c0-2443c95d2dd3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3916.5686" y="2729.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s564_sa265" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Stathmins family Stathmin 1 HUGO:STMN1 Stathmin 2 HUGO:STMN2 Stathmin 3 HUGO:STMN3 Stathmin 4 HUGO:STMN4</body> </html> </notes> <label text="Stathmin*"/> <bbox w="80.0" h="40.0" x="3709.0" y="2734.0"/> <glyph class="state variable" id="_c6389a30-3010-43fe-81c0-3829990b0d63"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3758.0686" y="2729.0"/> </glyph> </glyph> <glyph class="phenotype" id="s568_sa266" compartmentRef="c1_ca1"> <label text="microtubule fomation"/> <bbox w="150.0" h="25.0" x="4207.0" y="2827.5"/> </glyph> <glyph class="phenotype" id="s573_sa267" compartmentRef="c1_ca1"> <label text="destabilizing microtubule"/> <bbox w="160.0" h="25.0" x="3792.0" y="3097.5"/> </glyph> <glyph class="macromolecule" id="s575_sa269" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>protein tyrosine phosphatase, non-receptor type 1 HUGO:PTPN1</body> </html> </notes> <label text="PTP1B*"/> <bbox w="80.0" h="40.0" x="4602.0" y="2492.0"/> </glyph> <glyph class="nucleic acid feature" id="s576_sa270" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>protein tyrosine phosphatase, non-receptor type 1 HUGO:PTPN1</body> </html> </notes> <label text="PTP1B*"/> <bbox w="70.0" h="25.0" x="4117.0" y="2318.5"/> </glyph> <glyph class="nucleic acid feature" id="s577_sa271" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>protein tyrosine phosphatase, non-receptor type 1 HUGO:PTPN1</body> </html> </notes> <label text="PTP1B*"/> <bbox w="90.0" h="25.0" x="4307.0" y="2318.5"/> <glyph class="unit of information" id="_9fe2697f-8814-48bd-b9c8-ef1c3dd3bb60"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4342.0" y="2313.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s578_sa273" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Receptor tyrosine kinase epidermal growth factor receptor HUGO:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) HUGO:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) HUGO:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) HUGO:ERBB4</body> </html> </notes> <label text="EGFR family*"/> <bbox w="80.0" h="50.0" x="5187.0" y="2126.0"/> <glyph class="state variable" id="_edbdb167-f0d3-4a2c-9db9-6f657affda4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5222.0" y="2121.0"/> </glyph> <glyph class="unit of information" id="_c909b69c-89e7-4913-b4c3-228dd15987aa"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="5204.5" y="2121.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s579_sa274"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>transforming growth factor, alpha HUGO:TGFA heparin-binding EGF-like growth factor HUGO:HBEGF epidermal growth factor HUGO:EGF</body> </html> </notes> <label text="EGF family*"/> <bbox w="80.0" h="40.0" x="5334.0" y="2264.0"/> </glyph> <glyph class="phenotype" id="s591_sa276" compartmentRef="c1_ca1"> <label text="F-actin–rich membrane protrusions"/> <bbox w="280.0" h="25.0" x="4591.0" y="2635.5"/> </glyph> <glyph class="phenotype" id="s593_sa278"> <label text="PI3K AKT MTOR pathway"/> <bbox w="80.0" h="30.0" x="5382.0" y="2478.0"/> </glyph> <glyph class="phenotype" id="s594_sa279"> <label text="STAT pathway"/> <bbox w="80.0" h="30.0" x="5382.0" y="2538.0"/> </glyph> <glyph class="macromolecule" id="s601_sa283" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SLC9A3 regulator 1 HUGO:SLC9A3</body> </html> </notes> <label text="NHERF1*"/> <bbox w="80.0" h="40.0" x="689.0" y="2176.0"/> <glyph class="state variable" id="_7021919f-3c5e-43f4-9cf2-254c42ff8a61"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="738.06854" y="2171.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s604_sa284" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SLC9A3 regulator 1 HUGO:SLC9A3</body> </html> </notes> <label text="NHERF1*"/> <bbox w="80.0" h="40.0" x="839.0" y="2176.0"/> <glyph class="state variable" id="_60eb0c4e-fe78-4b63-b8d0-a1f61e9e827f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="890.56854" y="2171.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s609_sa287" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>lysine demethylase 4C "jumonji domain containing 2C", "lysine (K)-specific demethylase 4C" HUGO:KDM4C</body> </html> </notes> <label text="JMJD2C*"/> <bbox w="80.0" h="40.0" x="1063.0" y="1873.0"/> </glyph> <glyph class="nucleic acid feature" id="s632_sa288" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>LEO1 homolog, Paf1/RNA polymerase II complex component HUGO:LEO1</body> </html> </notes> <label text="LEO1"/> <bbox w="70.0" h="25.0" x="1719.0" y="1795.5"/> </glyph> <glyph class="nucleic acid feature" id="s633_sa289" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>LEO1 homolog, Paf1/RNA polymerase II complex component HUGO:LEO1</body> </html> </notes> <label text="LEO1"/> <bbox w="90.0" h="25.0" x="1697.0" y="1905.5"/> <glyph class="unit of information" id="_34e5de99-f7cd-4e2a-9a93-c358fed780c7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1732.0" y="1900.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s634_sa290" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>LEO1 homolog, Paf1/RNA polymerase II complex component HUGO:LEO1</body> </html> </notes> <label text="LEO1"/> <bbox w="80.0" h="40.0" x="1689.0" y="1998.0"/> </glyph> <glyph class="macromolecule" id="s635_sa291" compartmentRef="c2_ca2"> <label text="LEO1_binding partners*"/> <bbox w="160.0" h="20.0" x="1829.0" y="2018.0"/> </glyph> <glyph class="nucleic acid feature" id="s639_sa292" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SRY (sex determining region Y)-box 2 HUGO:SOX2</body> </html> </notes> <label text="SOX2"/> <bbox w="70.0" h="25.0" x="1969.0" y="2099.5"/> </glyph> <glyph class="nucleic acid feature" id="s640_sa293" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SRY (sex determining region Y)-box 2 HUGO:SOX2</body> </html> </notes> <label text="SOX2"/> <bbox w="90.0" h="25.0" x="1946.0" y="2185.5"/> <glyph class="unit of information" id="_f948a481-2cb0-4ffa-a540-91f184aee13f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="1981.0" y="2180.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s641_sa294" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SRY (sex determining region Y)-box 4 HUGO:SOX4</body> </html> </notes> <label text="SOX4"/> <bbox w="70.0" h="25.0" x="2083.0" y="2103.5"/> </glyph> <glyph class="nucleic acid feature" id="s642_sa295" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SRY (sex determining region Y)-box 4 HUGO:SOX4</body> </html> </notes> <label text="SOX4"/> <bbox w="90.0" h="25.0" x="2061.0" y="2190.5"/> <glyph class="unit of information" id="_5ce9864c-12e2-44aa-84b7-bccebf73e730"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2096.0" y="2185.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s446_sa296" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 HUGO:RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2</body> </html> </notes> <label text="S6K*"/> <bbox w="80.0" h="40.0" x="2012.0" y="1213.0"/> <glyph class="state variable" id="_99c2a796-2a64-4db2-8671-26519b9b6dc3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2063.5686" y="1208.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s650_sa299" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>golgi associated, gamma adaptin ear containing, ARF binding protein 1 HUGO:GGA1</body> </html> </notes> <label text="GGA1"/> <bbox w="80.0" h="40.0" x="4372.0" y="3378.0"/> </glyph> <glyph class="phenotype" id="s665_sa304" compartmentRef="c1_ca1"> <label text="ITGA5 & TFRC recycling"/> <bbox w="230.0" h="35.0" x="4674.0" y="2993.5"/> </glyph> <glyph class="phenotype" id="s666_sa305" compartmentRef="c1_ca1"> <label text="Migration"/> <bbox w="80.0" h="30.0" x="4749.0" y="2867.0"/> </glyph> <glyph class="macromolecule" id="s670_sa306" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Vinculin HUGO:VCL</body> </html> </notes> <label text="Vinculin*"/> <bbox w="80.0" h="40.0" x="2865.0" y="2948.0"/> </glyph> <glyph class="macromolecule" id="s671_sa307" compartmentRef="c1_ca1"> <label text="others*"/> <bbox w="80.0" h="40.0" x="2895.0" y="2848.0"/> </glyph> <glyph class="nucleic acid feature" id="s672_sa309" compartmentRef="c2_ca2"> <label text="MIR137"/> <bbox w="90.0" h="25.0" x="4335.0" y="1438.5"/> <glyph class="unit of information" id="_31523d87-1082-4d06-bb95-c93666fb1ace"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4365.0" y="1433.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s673_sa310" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 9 HUGO:MMP9</body> </html> </notes> <label text="MMP9"/> <bbox w="70.0" h="25.0" x="2945.0" y="2259.5"/> </glyph> <glyph class="nucleic acid feature" id="s674_sa311" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 9 HUGO:MMP9</body> </html> </notes> <label text="MMP9"/> <bbox w="90.0" h="25.0" x="2925.0" y="2361.5"/> <glyph class="unit of information" id="_e7c1e1ae-c299-48b6-94d4-fb6e4c8d2a3b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2960.0" y="2356.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s175_sa313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 9 HUGO:MMP9</body> </html> </notes> <label text="MMP9"/> <bbox w="80.0" h="40.0" x="3120.0" y="3469.0"/> </glyph> <glyph class="macromolecule" id="s677_sa314"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 9 (in extracellular space) HUGO:MMP9</body> </html> </notes> <label text="MMP9*"/> <bbox w="80.0" h="40.0" x="3120.0" y="3549.0"/> <glyph class="unit of information" id="_6a561fa6-04a9-4392-896b-807295286e99"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="3135.0" y="3544.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s678_sa315" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 14 HUGO:MMP14</body> </html> </notes> <label text="MMP14"/> <bbox w="70.0" h="25.0" x="2745.0" y="2259.5"/> </glyph> <glyph class="nucleic acid feature" id="s679_sa316" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 14 HUGO:MMP14</body> </html> </notes> <label text="MMP14"/> <bbox w="90.0" h="25.0" x="2727.0" y="2360.5"/> <glyph class="unit of information" id="_7bb4ba68-9731-4252-a0a1-a9a7c3b20f89"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2762.0" y="2355.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s682_sa319" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 10 HUGO:MMP10</body> </html> </notes> <label text="MMP10"/> <bbox w="70.0" h="25.0" x="2835.0" y="2259.5"/> </glyph> <glyph class="nucleic acid feature" id="s683_sa320" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 10 HUGO:MMP10</body> </html> </notes> <label text="MMP10"/> <bbox w="90.0" h="25.0" x="2820.0" y="2359.5"/> <glyph class="unit of information" id="_5c9481d5-1d2b-4cc2-851e-66e5f830b503"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2855.0" y="2354.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s177_sa322"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 10 HUGO:MMP10</body> </html> </notes> <label text="MMP10"/> <bbox w="80.0" h="40.0" x="3010.0" y="3469.0"/> </glyph> <glyph class="macromolecule" id="s686_sa323"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>matrix metallopeptidase 10 (in extracellular space) HUGO:MMP10</body> </html> </notes> <label text="MMP10*"/> <bbox w="80.0" h="40.0" x="3010.0" y="3549.0"/> <glyph class="unit of information" id="_094f67c4-fc1e-4ad1-8286-5c3c80c95e15"> <label text="truncated"/> <bbox w="50.0" h="10.0" 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as-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) HUGO:RAC3 as-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)</body> </html> </notes> <label text="RAC*"/> <bbox w="80.0" h="40.0" x="4579.0" y="1432.0"/> </glyph> <glyph class="phenotype" id="s693_sa330" compartmentRef="c1_ca1"> <label text="Actin remodeling"/> <bbox w="120.0" h="25.0" x="4504.0" y="1301.5"/> </glyph> <glyph class="macromolecule" id="s695_sa332" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:KDR Kinase insert domain receptor</body> </html> </notes> <label text="VEGFR2"/> <bbox w="80.0" h="50.0" x="5191.0" y="2594.0"/> <glyph class="state variable" id="_4a8580da-359b-4968-b4b8-534765c92114"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5186.0" y="2603.6448"/> </glyph> <glyph class="unit of information" id="_6f8252b6-b382-426d-8093-87cde54cae62"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="5208.5" y="2589.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s706_sa333" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 HUGO:SRC</body> </html> </notes> <label text="Src"/> <bbox w="80.0" h="40.0" x="3566.875" y="914.625"/> <glyph class="state variable" id="_740919cf-1841-4a9f-b34e-713abd552e3d"> <state value="P" variable="Tyr416"/> <bbox w="45.0" h="10.0" x="3584.2795" y="949.625"/> </glyph> <glyph class="state variable" id="_7ee099fe-1925-4a9a-a358-442873ba8e57"> <state value="" variable="Tyr527"/> <bbox w="40.0" h="10.0" x="3626.875" y="937.92065"/> </glyph> </glyph> <glyph class="phenotype" id="s707_sa334" compartmentRef="c1_ca1"> <label text="MAPK* activation"/> <bbox w="80.0" h="30.0" x="4640.0" y="2792.0"/> </glyph> <glyph class="macromolecule" id="s708_sa337"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TNF Tumor necrosis factor</body> </html> </notes> <label text="TNFα*"/> <bbox w="80.0" h="40.0" x="6.0" y="1371.0"/> </glyph> <glyph class="macromolecule" id="s709_sa338" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TNFRSF1A TNF receptor superfamily member 1A</body> </html> </notes> <label text="TNF-R1*"/> <bbox w="80.0" h="50.0" x="119.0" y="1394.0"/> <glyph class="unit of information" id="_a387a379-feed-41f5-8ba7-5b581a822fc4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="136.5" y="1389.0"/> </glyph> </glyph> <glyph class="phenotype" id="s714_sa339" compartmentRef="c1_ca1"> <label text="Senescence"/> <bbox w="80.0" h="30.0" x="359.0" y="1612.0"/> </glyph> <glyph class="phenotype" id="s715_sa340" compartmentRef="c1_ca1"> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="363.0" y="1702.0"/> </glyph> <glyph class="macromolecule" id="s717_sa341"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:MMP14 Identifiers_end</body> </html> </notes> <label text="MMP14*"/> <bbox w="80.0" h="40.0" x="2872.0" y="3555.0"/> <glyph class="unit of information" id="_bc2f5fc7-446e-4ceb-8900-1fe2c3289ebd"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="2887.0" y="3550.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s718_sa343" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:JAM2 junctional adhesion molecule 2</body> </html> </notes> <label text="JAM2"/> <bbox w="80.0" h="40.0" x="1913.0" y="3137.0"/> </glyph> <glyph class="phenotype" id="s722_sa344"> <label text="Cell adhesion"/> <bbox w="80.0" h="30.0" x="1984.0" y="3460.0"/> </glyph> <glyph class="phenotype" id="s724_sa346" compartmentRef="c1_ca1"> <label text="Autophagy"/> <bbox w="80.0" h="30.0" x="1772.0" y="508.0"/> </glyph> <glyph class="nucleic acid feature" id="s725_sa347" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:IL4 Interleukin 4</body> </html> </notes> <label text="IL-4*"/> <bbox w="70.0" h="25.0" x="3696.0" y="2312.5"/> </glyph> <glyph class="nucleic acid feature" id="s726_sa348" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:IL4 Interleukin 4</body> </html> </notes> <label text="IL-4*"/> <bbox w="90.0" h="25.0" x="3837.0" y="2317.5"/> <glyph class="unit of information" id="_e9ea0908-4c6b-4b9e-80c3-68c4582403be"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="3872.0" y="2312.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s727_sa349" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:IL4 Interleukin 4</body> </html> </notes> <label text="IL-4*"/> <bbox w="80.0" h="40.0" x="3993.0" y="2309.0"/> </glyph> <glyph class="phenotype" id="s728_sa350" compartmentRef="c1_ca1"> <label text="BCR-ABL signalling"/> <bbox w="174.0" h="28.0" x="1307.0" y="223.0"/> </glyph> <glyph class="macromolecule" id="s730_sa353" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:IL6 Interleukin 6</body> </html> </notes> <label text="IL-6*"/> <bbox w="80.0" h="40.0" x="3888.0" y="1425.0"/> </glyph> <glyph class="macromolecule" id="s755_sa354" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>FBJ murine osteosarcoma viral oncogene homolog HUGO:FOS</body> </html> </notes> <label text="FOS"/> <bbox w="80.0" h="40.0" x="2345.125" y="2389.5"/> <glyph class="state variable" id="_36c116f1-2741-4855-bf5d-dfa5528159ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2394.1936" y="2384.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s756_sa355" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>mitogen-activated protein kinase 8 JNK1 HUGO:MAPK8 mitogen-activated protein kinase 9 JNK2 HUGO:MAPK9 mitogen-activated protein kinase 10 JNK3 HUGO:MAPK10 JNK1, mitogen-activated protein kinase 8 JNK2, mitogen-activated protein kinase 9 JNK3, mitogen-activated protein kinase 10 PRKM8 PRKM9 PRKM10</body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="2466.5" y="2240.0"/> <glyph class="state variable" id="_f1b8f10f-22de-45e3-94cf-b2157515dd27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2518.0686" y="2235.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s757_sa356" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>mitogen-activated protein kinase 8 JNK1 HUGO:MAPK8 mitogen-activated protein kinase 9 JNK2 HUGO:MAPK9 mitogen-activated protein kinase 10 JNK3 HUGO:MAPK10 JNK1, mitogen-activated protein kinase 8 JNK2, mitogen-activated protein kinase 9 JNK3, mitogen-activated protein kinase 10 PRKM8 PRKM9 PRKM10</body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="2467.625" y="2330.5"/> <glyph class="state variable" id="_bd0b5934-ee68-4c93-8c73-ce0cecb55ea3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2516.6936" y="2325.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s758_sa357" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)"</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="2593.5" y="2282.0"/> <glyph class="state variable" id="_f1ed86b9-08a5-4676-be5b-5a2884ab27fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2668.5" y="2288.7158"/> </glyph> </glyph> <glyph class="macromolecule" id="s759_sa358" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)"</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="2597.125" y="2396.5"/> <glyph class="state variable" id="_0509b34f-c596-410f-81f6-f43a5a95d00a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2669.625" y="2403.2158"/> </glyph> </glyph> <glyph class="macromolecule" id="s760_sa359" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>cyclin-dependent kinase inhibitor 2A CDKN2 "cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4)" MLM HUGO:CDKN2A</body> </html> </notes> <label text="p14ARF*"/> <bbox w="80.0" h="40.0" x="2386.5" y="1323.0"/> </glyph> <glyph class="nucleic acid feature" id="s761_sa360" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>cyclin-dependent kinase inhibitor 2A CDKN2 "cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4)" MLM HUGO:CDKN2A</body> </html> </notes> <label text="p14ARF*"/> <bbox w="70.0" h="25.0" x="2346.5" y="1516.5"/> </glyph> <glyph class="nucleic acid feature" id="s762_sa361" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>cyclin-dependent kinase inhibitor 2A CDKN2 "cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4)" MLM HUGO:CDKN2A</body> </html> </notes> <label text="p14ARF*"/> <bbox w="90.0" h="25.0" x="2347.5" y="1435.5"/> <glyph class="unit of information" id="_a6bbabd6-6fc0-49b5-9b3a-d5a9e630a43a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2382.5" y="1430.5"/> </glyph> </glyph> <glyph class="phenotype" id="s764_sa363" compartmentRef="c1_ca1"> <label text="G2/M phase"/> <bbox w="80.0" h="30.0" x="3178.5" y="930.0"/> </glyph> <glyph class="nucleic acid feature" id="s765_sa364" compartmentRef="c2_ca2"> <label text="CCL26"/> <bbox w="70.0" h="25.0" x="2208.5" y="1600.5"/> </glyph> <glyph class="nucleic acid feature" id="s766_sa365" compartmentRef="c2_ca2"> <label text="CCL26"/> <bbox w="90.0" h="25.0" x="2216.5" y="1528.5"/> <glyph class="unit of information" id="_10640d6c-3dac-4aaf-a466-fee86fa936dc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="2251.5" y="1523.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s767_sa367"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CCL26 C-C motif chemokine ligand 26</body> </html> </notes> <label text="CCL26"/> <bbox w="80.0" h="40.0" x="2808.3333" y="18.666666"/> </glyph> <glyph class="macromolecule" id="s769_sa368" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:CCR3 C-C motif chemokine receptor 3</body> </html> </notes> <label text="CCR3"/> <bbox w="80.0" h="50.0" x="2870.5" y="55.0"/> <glyph class="unit of information" id="_bb212dae-ab2f-4262-b322-a7fa1f0f4f34"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2888.0" y="50.0"/> </glyph> </glyph> <glyph class="phenotype" id="s775_sa369" compartmentRef="c1_ca1"> <label text="TAM infiltration"/> <bbox w="80.0" h="30.0" x="3254.5" y="48.0"/> </glyph> <glyph class="complex" id="s159_csa1" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>PMID:18078820</body> </html> </notes> <label text="Actin fibers* / Ezrin"/> <bbox w="199.0" h="118.0" x="2165.5" y="271.5"/> <glyph class="macromolecule" id="s156_sa370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:EZR Ezrin</body> </html> </notes> <label text="EZR"/> <bbox w="80.0" h="40.0" x="2220.8333" y="282.5"/> <glyph class="state variable" id="_cb8b3913-8c73-4cd9-a52d-4cbaae09ee6d"> <state value="P" variable="Thr 567"/> <bbox w="50.0" h="10.0" x="2252.7825" y="277.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s158_sa371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:ACTA1, HUGO:ACTA2, HUGO:ACTB, HUGO:ACTC1, HUGO:ACTG1, HUGO:ACTG2 Identifiers_end</body> </html> </notes> <label text="Actin fibers*"/> <bbox w="182.0" h="35.0" x="2173.8333" y="332.5"/> </glyph> </glyph> <glyph class="complex" id="s87_csa2" compartmentRef="c1_ca1"> <label text="RAC1_GTP"/> <bbox w="100.0" h="120.0" x="4196.0" y="129.71428"/> <glyph class="macromolecule" id="s85_sa372"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RAC1 as-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="4206.7144" y="159.71428"/> </glyph> <glyph class="simple chemical" id="s84_sa373"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="4213.0" y="201.21428"/> </glyph> </glyph> <glyph class="complex" id="s86_csa3" compartmentRef="c1_ca1"> <label text="RAC1_GDP"/> <bbox w="100.0" h="120.0" x="4475.0" y="129.71428"/> <glyph class="macromolecule" id="s82_sa374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RAC1 as-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="4484.0" y="156.71428"/> </glyph> <glyph class="simple chemical" id="s81_sa375"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="4488.0" y="199.21428"/> </glyph> </glyph> <glyph class="complex" id="s169_csa4" compartmentRef="c1_ca1"> <label text="Formin*/Profilin*/Actin cytoskeletal*"/> <bbox w="180.0" h="214.0" x="4334.0" y="679.0"/> <glyph class="macromolecule" id="s172_sa376"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Identifiers_begin: HUGO:ACTA1, HUGO:ACTA2, HUGO:ACTB, HUGO:ACTC1, HUGO:ACTG1, HUGO:ACTG2 Identifiers_end</body> </html> </notes> <label text="Actin cytoskeletal*"/> <bbox w="162.0" h="37.0" x="4341.4116" y="799.82355"/> </glyph> <glyph class="macromolecule" id="s170_sa377"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>formin 1 HUGO:FMN1</body> </html> </notes> <label text="Formin*"/> <bbox w="80.0" h="40.0" x="4384.0" y="696.0"/> </glyph> <glyph class="macromolecule" id="s171_sa378"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Profilin 1 HUGO:PFN1</body> </html> </notes> <label text="Profilin*"/> <bbox w="80.0" h="40.0" x="4379.4116" y="744.82355"/> </glyph> </glyph> <glyph class="complex" id="s165_csa5" compartmentRef="c1_ca1"> <label text="Formin*/Profilin"/> <bbox w="115.0" h="143.0" x="4746.0" y="505.0"/> <glyph class="macromolecule" id="s166_sa379"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>formin 1 HUGO:FMN1</body> </html> </notes> <label text="Formin*"/> <bbox w="80.0" h="40.0" x="4762.4116" y="516.4706"/> </glyph> <glyph class="macromolecule" id="s167_sa380"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Profilin 1 HUGO:PFN1</body> </html> </notes> <label text="Profilin*"/> <bbox w="80.0" h="40.0" x="4762.4116" y="569.4706"/> </glyph> </glyph> <glyph class="complex" id="s88_csa6" compartmentRef="c1_ca1"> <label text="RhoA_GTP"/> <bbox w="100.0" h="120.0" x="4196.0" y="319.0"/> <glyph class="macromolecule" id="s77_sa381"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ras homolog family member A HUGO:RHOA</body> </html> </notes> <label text="RHOA"/> <bbox w="80.0" h="40.0" x="4206.7144" y="349.0"/> </glyph> <glyph class="simple chemical" id="s79_sa382"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="4213.0" y="390.5"/> </glyph> </glyph> <glyph class="complex" id="s96_csa7" compartmentRef="c1_ca1"> <label text="RhoC_GTP"/> <bbox w="100.0" h="120.0" x="4196.0" y="471.85715"/> <glyph class="macromolecule" id="s94_sa383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ras homolog family member C HUGO:RHOC</body> </html> </notes> <label text="RHOC"/> <bbox w="80.0" h="40.0" x="4206.7144" y="501.85715"/> </glyph> <glyph class="simple chemical" id="s93_sa384"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="4213.0" y="543.3571"/> </glyph> </glyph> <glyph class="complex" id="s95_csa8" compartmentRef="c1_ca1"> <label text="RhoC_GDP"/> <bbox w="100.0" h="120.0" x="4475.0" y="471.85715"/> <glyph class="macromolecule" id="s91_sa385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ras homolog family member C HUGO:RHOC</body> </html> </notes> <label text="RHOC"/> <bbox w="80.0" h="40.0" x="4484.0" y="498.85715"/> </glyph> <glyph class="simple chemical" id="s90_sa386"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="4488.0" y="541.3571"/> </glyph> </glyph> <glyph class="complex" id="s75_csa9" compartmentRef="c1_ca1"> <label text="RhoA_GDP"/> <bbox w="100.0" h="120.0" x="4475.0" y="319.0"/> <glyph class="macromolecule" id="s74_sa387"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ras homolog family member A HUGO:RHOA</body> </html> </notes> <label text="RHOA"/> <bbox w="80.0" h="40.0" x="4484.0" y="346.0"/> </glyph> <glyph class="simple chemical" id="s97_sa388"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="4489.0713" y="388.5"/> </glyph> </glyph> <glyph class="complex" id="s409_csa10" compartmentRef="c6_ca6"> <label text="ULBP2/HSP60*"/> <bbox w="100.0" h="120.0" x="4679.0" y="955.0"/> <glyph class="macromolecule" id="s410_sa389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>UL16 binding protein 2 HUGO:ULBP2</body> </html> </notes> <label text="ULBP2"/> <bbox w="80.0" h="40.0" x="4689.0" y="965.0"/> <glyph class="state variable" id="_28b10684-b13b-490e-8873-8938cb59e9ce"> <state value="" variable="GPI"/> <bbox w="25.0" h="10.0" x="4700.095" y="960.0"/> </glyph> <glyph class="state variable" id="_290c6635-fee5-4adf-9362-82d807baaa41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4740.5684" y="960.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s411_sa390"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein family D (Hsp60) member 1 HUGO:HSPD1</body> </html> </notes> <label text="HSP60*"/> <bbox w="80.0" h="40.0" x="4689.0" y="1015.0"/> <glyph class="state variable" id="_bc450b41-37a9-4006-9475-380c27c8baca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4740.5684" y="1010.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s390_csa11" compartmentRef="c2_ca2"> <label text="MEF2C/PTP4A3"/> <bbox w="220.0" h="110.0" x="4351.0" y="1780.0"/> <glyph class="nucleic acid feature" id="s392_sa391"> <label text="PTP4A3 promoter biding site*"/> <bbox w="185.0" h="22.5" x="4368.5" y="1848.75"/> </glyph> <glyph class="macromolecule" id="s391_sa392"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>myocyte enhancer factor 2C HUGO:MEF2C</body> </html> </notes> <label text="MEF2C"/> <bbox w="80.0" h="40.0" x="4421.0" y="1790.0"/> </glyph> </glyph> <glyph class="complex" id="s236_csa12" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>5-Aza-dC sequesters DNMT enzyme activity by irreversibly binding DNMT PMID:25475733</body> </html> </notes> <label text="DNMT/5-Aza-dC*"/> <bbox w="100.0" h="120.0" x="4121.0" y="1729.0"/> <glyph class="macromolecule" id="s237_sa393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>DNA methyltransferase 1 HUGO:DMNT1</body> </html> </notes> <label text="DNMT*"/> <bbox w="80.0" h="40.0" x="4131.0527" y="1740.8422"/> </glyph> <glyph class="simple chemical" id="s238_sa394"> <label text="5-Aza-dC*"/> <bbox w="80.0" h="30.0" x="4130.0527" y="1782.8422"/> <glyph class="unit of information" id="_ed212d27-c866-42ca-ace3-2c57d3aa6857"> <label text="drug"/> <bbox w="25.0" h="10.0" x="4157.5527" y="1777.8422"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s418_csa13" compartmentRef="c6_ca6"> <label text="ULBP2/HSP60*"/> <bbox w="100.0" h="120.0" x="4839.0" y="1127.0"/> <glyph class="macromolecule" id="s420_sa395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>UL16 binding protein 2 HUGO:ULBP2</body> </html> </notes> <label text="ULBP2"/> <bbox w="80.0" h="40.0" x="4849.0" y="1137.0"/> <glyph class="state variable" id="_502d980a-f16e-4dbe-a534-55a15f11262f"> <state value="*" variable="GPI"/> <bbox w="30.0" h="10.0" x="4857.595" y="1132.0"/> </glyph> <glyph class="state variable" id="_72a6c2dc-9d6f-46fa-82ba-efe865de377c"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="4898.0684" y="1132.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s419_sa396"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein family D (Hsp60) member 1 HUGO:HSPD1</body> </html> </notes> <label text="HSP60*"/> <bbox w="80.0" h="40.0" x="4849.0" y="1187.0"/> <glyph class="state variable" id="_b5981d7b-2fd5-4c35-a757-d8a5e63c3b12"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4898.0684" y="1182.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s426_csa14" compartmentRef="c6_ca6"> <label text="ULBP2/HSP60*"/> <bbox w="100.0" h="120.0" x="4679.0" y="1127.0"/> <glyph class="macromolecule" id="s427_sa397"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>UL16 binding protein 2 HUGO:ULBP2</body> </html> </notes> <label text="ULBP2"/> <bbox w="80.0" h="40.0" x="4689.0" y="1137.0"/> <glyph class="state variable" id="_b560c5f3-92aa-4d0d-8e28-e886ca5dbdad"> <state value="" variable="GPI"/> <bbox w="25.0" h="10.0" x="4700.095" y="1132.0"/> </glyph> <glyph class="state variable" id="_110baffc-3735-4c5d-88b6-c0ae6328aef3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4740.5684" y="1132.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s428_sa398"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>heat shock protein family D (Hsp60) member 1 HUGO:HSPD1</body> </html> </notes> <label text="HSP60*"/> <bbox w="80.0" h="40.0" x="4689.0" y="1187.0"/> <glyph class="state variable" id="_015ad85f-fff4-4907-b2a5-9d942658dafc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4738.0684" y="1182.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s196_csa15" compartmentRef="c2_ca2"> <label text="SMAD2_3*/SMAD4/SBE promoter*"/> <bbox w="147.0" h="173.0" x="3748.5" y="1507.5"/> <glyph class="macromolecule" id="s190_sa399"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SMAD family member 2 HUGO:SMAD2 SMAD family member 3 HUGO:SMAD3</body> </html> </notes> <label text="SMAD2_3*"/> <bbox w="80.0" h="40.0" x="3780.5" y="1516.8334"/> <glyph class="state variable" id="_4c753971-c4fd-4baf-812f-c46163bb39c1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3829.5686" y="1511.8334"/> </glyph> </glyph> <glyph class="macromolecule" id="s191_sa400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SMAD family member 4 HUGO:SMAD4</body> </html> </notes> <label text="SMAD4"/> <bbox w="80.0" h="40.0" x="3780.5" y="1574.8334"/> <glyph class="state variable" id="_764c38e6-1ace-4de2-b171-94bb87e96c26"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3829.5686" y="1569.8334"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s192_sa401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>There are 2 Smad binding element sites (SBE: E1 and E4) in PRL-3 promoter</body> </html> </notes> <label text="SBE promoter*"/> <bbox w="117.0" h="22.0" x="3763.5" y="1626.8334"/> </glyph> </glyph> <glyph class="complex" id="s195_csa16" compartmentRef="c2_ca2"> <label text="SMAD2_3*/SMAD4"/> <bbox w="111.0" h="149.0" x="3561.5" y="1424.5"/> <glyph class="macromolecule" id="s186_sa402"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SMAD family member 2 HUGO:SMAD2 SMAD family member 3 HUGO:SMAD3</body> </html> </notes> <label text="SMAD2_3*"/> <bbox w="80.0" h="40.0" x="3574.9285" y="1439.0714"/> <glyph class="state variable" id="_7477ec19-348a-4651-b153-20ebae9d3b1b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3623.997" y="1434.0714"/> </glyph> </glyph> <glyph class="macromolecule" id="s187_sa403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>SMAD family member 4 HUGO:SMAD4</body> </html> </notes> <label text="SMAD4"/> <bbox w="80.0" h="40.0" x="3573.9285" y="1494.0714"/> <glyph class="state variable" id="_94301434-e60e-438c-93dd-b90fad8442a0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3622.997" y="1489.0714"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s246_csa17" compartmentRef="c1_ca1"> <label text="PTP4A3/RAP1*"/> <bbox w="100.0" h="120.0" x="239.0" y="1733.5"/> <glyph class="macromolecule" id="s243_sa404"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>TERF2 interacting protein HUGO:TERF2IP</body> </html> </notes> <label text="RAP1*"/> <bbox w="80.0" h="40.0" x="251.0" y="1792.5"/> </glyph> <glyph class="macromolecule" id="s245_sa405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTP4A3 protein tyrosine phosphatase type IVA, member 3</body> </html> </notes> <label text="PTP4A3"/> <bbox w="80.0" h="40.0" x="251.08333" y="1747.1666"/> <glyph class="state 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class="state variable" id="_efec396d-32ba-4732-b8f3-fc75d7cf063d"> <state value="" variable="Y53"/> <bbox w="25.0" h="10.0" x="1999.0686" y="3026.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s348_sa407"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, alpha 1 HUGO:ITGA1</body> </html> </notes> <label text="ITGA1"/> <bbox w="80.0" h="40.0" x="1955.0" y="2931.0"/> </glyph> <glyph class="macromolecule" id="s362_sa408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) HUGO:ITGB1</body> </html> </notes> <label text="ITGB1"/> <bbox w="80.0" h="40.0" x="1954.0" y="2980.0"/> <glyph class="state variable" id="_7570e1d9-67ce-41e5-83aa-4d6e6e26a831"> <state value="P" variable="Y783"/> <bbox 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTP4A3 protein tyrosine phosphatase type IVA, member 3</body> </html> </notes> <label text="PTP4A3"/> <bbox w="80.0" h="40.0" x="1795.0" y="3027.0"/> <glyph class="state variable" id="_4be41a18-2ede-4da9-a2ef-f02561a4d919"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1790.0" y="3033.7158"/> </glyph> <glyph class="state variable" id="_6b164643-8e9b-41a5-b475-ddb0fb358d18"> <state value="" variable="Y53"/> <bbox w="25.0" h="10.0" x="1839.0686" y="3022.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s365_sa415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, alpha 1 HUGO:ITGA1</body> </html> </notes> <label text="ITGA1"/> <bbox w="80.0" h="40.0" x="1795.0" y="2927.0"/> </glyph> </glyph> <glyph class="complex" id="s780_csa22" compartmentRef="c1_ca1"> <label text="a1b1*"/> <bbox w="100.0" h="120.0" x="1994.0" y="2569.0"/> <glyph class="macromolecule" id="s781_sa416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, alpha 1 HUGO:ITGA1</body> </html> </notes> <label text="ITGA1"/> <bbox w="80.0" h="40.0" x="2003.0" y="2642.0"/> </glyph> <glyph class="macromolecule" id="s781_sa417"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, alpha 1 HUGO:ITGA1</body> </html> </notes> <label text="ITGA1"/> <bbox w="80.0" h="40.0" x="2004.0" y="2579.0"/> </glyph> <glyph class="macromolecule" id="s782_sa418"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) HUGO:ITGB1</body> </html> </notes> <label text="ITGB1"/> <bbox w="80.0" h="40.0" x="2004.0" y="2614.0"/> <glyph class="state variable" id="_6c072d58-f49b-4b42-809b-79d6c3f8c23e"> <state value="" variable="Y783"/> <bbox w="30.0" h="10.0" x="2045.9493" y="2609.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s743_csa24" compartmentRef="c1_ca1"> <label text="a1b1*"/> <bbox w="100.0" h="120.0" x="1792.0" y="3165.0"/> <glyph class="macromolecule" id="s744_sa421"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, alpha 1 HUGO:ITGA1</body> </html> </notes> <label text="ITGA1"/> <bbox w="80.0" h="40.0" x="1802.0" y="3175.0"/> </glyph> <glyph class="macromolecule" id="s745_sa422"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) HUGO:ITGB1</body> </html> </notes> <label text="ITGB1"/> <bbox w="80.0" h="40.0" x="1802.0" y="3225.0"/> <glyph class="state variable" id="_ed00aad6-544f-4516-8d55-07151aa21080"> <state value="" variable="Y783"/> <bbox w="30.0" h="10.0" x="1843.9493" y="3220.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s274_csa26" compartmentRef="c1_ca1"> <label text="Focal adhesion complex*"/> <bbox w="232.5" h="144.0" x="2552.5" y="2886.0"/> <glyph class="macromolecule" id="s275_sa425"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>paxillin HUGO:PXN</body> </html> </notes> <label text="PXN"/> <bbox w="80.0" h="40.0" x="2579.8845" y="2901.6924"/> <glyph class="state variable" id="_e1fe054d-e5dd-44b2-a063-59baffe6c4f2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2628.9531" y="2896.6924"/> </glyph> </glyph> <glyph class="macromolecule" id="s276_sa426"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>protein tyrosine kinase 2 HUGO:PTK2</body> </html> </notes> <label text="FAK*"/> <bbox w="80.0" h="40.0" x="2581.8845" y="2956.6924"/> <glyph class="state variable" id="_38bc9fe2-55b6-4dd7-b539-f61306833599"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2630.9531" y="2951.6924"/> </glyph> </glyph> <glyph class="macromolecule" id="s668_sa427"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Vinculin HUGO:VCL</body> </html> </notes> <label text="Vinculin*"/> <bbox w="80.0" h="40.0" x="2675.0" y="2950.0"/> </glyph> <glyph class="macromolecule" id="s669_sa428"> <label text="others*"/> <bbox w="80.0" h="40.0" x="2675.0" y="2900.0"/> </glyph> </glyph> <glyph class="complex" id="s204_csa28" compartmentRef="c1_ca1"> <label text="ARF1_GTP"/> <bbox w="100.0" h="120.0" x="3788.0" y="3230.0"/> <glyph class="simple chemical" id="s203_sa432"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="3803.0" y="3287.5"/> </glyph> <glyph class="macromolecule" id="s201_sa433"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ADP ribosylation factor 1 HUGO:ARF1</body> </html> </notes> <label text="ARF1"/> <bbox w="80.0" h="40.0" x="3801.3333" y="3241.3333"/> </glyph> </glyph> <glyph class="complex" id="s200_csa29" compartmentRef="c1_ca1"> <label text="ARF1_GDP"/> <bbox w="100.0" h="120.0" x="3528.0" y="3230.0"/> <glyph class="macromolecule" id="s198_sa434"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ADP ribosylation factor 1 HUGO:ARF1</body> </html> </notes> <label text="ARF1"/> <bbox w="80.0" h="40.0" x="3537.0" y="3243.0"/> 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w="80.0" h="40.0" x="3599.0" y="385.5"/> </glyph> <glyph class="macromolecule" id="s499_sa446"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Rag guanine nucleotide exchange factor HUGO:RRAGA, HUGO:RRAGB</body> </html> </notes> <label text="Rag A/B*"/> <bbox w="80.0" h="40.0" x="3599.0" y="315.5"/> </glyph> </glyph> <glyph class="complex" id="s456_csa33" compartmentRef="c5_ca5"> <label text="RHEB:GDP"/> <bbox w="100.0" h="120.0" x="2474.125" y="607.5"/> <glyph class="macromolecule" id="s457_sa447"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RHEB Ras homolog enriched in brain</body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="2484.125" y="617.5"/> </glyph> <glyph class="simple chemical" id="s454_sa448"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="2489.125" y="665.0"/> </glyph> </glyph> <glyph class="complex" id="s458_csa34" compartmentRef="c5_ca5"> <label text="RHEB:GTP"/> <bbox w="100.0" h="120.0" x="2624.125" y="607.5"/> <glyph class="macromolecule" id="s453_sa449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RHEB Ras homolog enriched in brain</body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="2634.125" y="617.5"/> </glyph> <glyph class="simple chemical" id="s455_sa450"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="2639.125" y="665.0"/> </glyph> </glyph> <glyph class="complex" id="s489_csa36" compartmentRef="c1_ca1"> <label text="RTK*_Ligand"/> <bbox w="130.0" h="160.0" x="1158.0" y="11.0"/> <glyph class="macromolecule" id="s491_sa454"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Receptor tyrosine kinase epidermal growth factor receptor HUGO:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian)NGL HUGO:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)LCCS2 HUGO:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) HUGO:ERBB4 fibroblast growth factor receptor 1 HUGO:FGFR1 fibroblast growth factor receptor 2 HUGO:FGFR2 fibroblast growth factor receptor 3 HUGO:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 fms-related tyrosine kinase 1 FLT HUGO:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA platelet-derived growth factor receptor beta polypeptide HUGO:PDGFRB v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog insulin-like growth factor 1 receptor HUGO:IGF1R EPH receptor A1 HUGO:EPHA1 EPH receptor A2 EPH receptor B1 EPH receptor B2 PDGFR A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="105.0" x="1183.0" y="48.5"/> <glyph class="state variable" id="_cbb94020-67ac-49c8-b0c7-2157607e03ba"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1265.5" y="117.746216"/> </glyph> <glyph class="state variable" id="_d3254dda-0855-47ea-8600-e6bed566c957"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1265.5" y="74.253784"/> </glyph> <glyph class="unit of information" id="_7b9c17bd-984d-44cf-b53e-0e699c18a116"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1205.5" y="43.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s491_sa455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Receptor tyrosine kinase epidermal growth factor receptor HUGO:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian)NGL HUGO:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)LCCS2 HUGO:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) HUGO:ERBB4 fibroblast growth factor receptor 1 HUGO:FGFR1 fibroblast growth factor receptor 2 HUGO:FGFR2 fibroblast growth factor receptor 3 HUGO:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 fms-related tyrosine kinase 1 FLT HUGO:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA platelet-derived growth factor receptor beta polypeptide HUGO:PDGFRB v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog insulin-like growth factor 1 receptor HUGO:IGF1R EPH receptor A1 HUGO:EPHA1 EPH receptor A2 EPH receptor B1 EPH receptor B2 PDGFR A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="105.0" x="1173.0" y="38.5"/> <glyph class="state variable" id="_77c295c9-d892-43f1-a45f-1e5b894887ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1255.5" y="107.746216"/> </glyph> <glyph class="state variable" id="_569649ca-4aa9-4e07-817b-112ef09fa74b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1255.5" y="64.253784"/> </glyph> <glyph class="unit of information" id="_2ae1203d-cdb9-4e25-a6c4-4e1554a4c12c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1195.5" y="33.5"/> </glyph> </glyph> <glyph class="simple chemical" id="s490_sa456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Growth factor</body> </html> </notes> <label text="GF"/> <bbox w="70.0" h="25.0" x="1183.0" y="18.5"/> </glyph> </glyph> <glyph class="complex" id="s493_csa37" compartmentRef="c5_ca5"> <label text="TSC1/2"/> <bbox w="100.0" h="120.0" x="2624.125" y="437.5"/> <glyph class="macromolecule" id="s434_sa457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TSC2 tuberous sclerosis 2</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="2634.125" y="497.5"/> <glyph class="state variable" id="_94cc3fdc-1d20-4da5-9661-26488a2358c7"> <state value="P" variable="S939"/> <bbox w="35.0" h="10.0" x="2674.5261" y="492.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s492_sa458"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TSC1 tuberous sclerosis 1</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="2634.125" y="447.5"/> </glyph> </glyph> <glyph class="complex" id="s494_csa38" compartmentRef="c5_ca5"> <label text="TSC1/2"/> <bbox w="100.0" h="120.0" x="2474.125" y="437.5"/> <glyph class="macromolecule" id="s433_sa459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TSC2 tuberous sclerosis 2</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="2484.125" y="497.5"/> <glyph class="state variable" id="_691e4d95-5a6f-49e2-821a-b10541fb08c6"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="2527.0261" y="492.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s495_sa460"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TSC1 tuberous sclerosis 1</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="2484.125" y="447.5"/> </glyph> </glyph> <glyph class="complex" id="s35_csa39" compartmentRef="c1_ca1"> <label text="RagGTPases"/> <bbox w="120.0" h="165.0" x="3281.0" y="312.5"/> <glyph class="macromolecule" id="s37_sa461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Rag guanine nucleotide exchange factor HUGO:RRAGC, HUGO:RRAGD</body> </html> </notes> <label text="Rag C/D*"/> <bbox w="80.0" h="40.0" x="3301.0" y="387.5"/> </glyph> <glyph class="simple chemical" id="s38_sa462"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="3306.0" y="425.0"/> </glyph> <glyph class="macromolecule" id="s39_sa463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Rag guanine nucleotide exchange factor HUGO:RRAGA, HUGO:RRAGB</body> </html> </notes> <label text="Rag A/B*"/> <bbox w="80.0" h="40.0" x="3301.0" y="317.5"/> </glyph> <glyph class="simple chemical" id="s40_sa464"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="3306.0" y="355.0"/> </glyph> <glyph class="simple chemical" id="s38_sa465"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="3284.0" y="428.0"/> </glyph> <glyph class="simple chemical" id="s38_sa466"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="3284.0" y="358.0"/> </glyph> </glyph> <glyph class="complex" id="s280_csa41" compartmentRef="c5_ca5"> <label text="RagGTPases"/> <bbox w="120.0" h="165.0" x="2895.375" y="770.0"/> <glyph class="macromolecule" id="s281_sa470"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Rag guanine nucleotide exchange factor HUGO:RRAGC, HUGO:RRAGD</body> </html> </notes> <label text="Rag C/D*"/> <bbox w="80.0" h="40.0" x="2915.375" y="845.0"/> </glyph> <glyph class="simple chemical" id="s282_sa471"> <label text="GDP"/> <bbox w="70.0" h="25.0" x="2920.375" y="882.5"/> </glyph> <glyph class="macromolecule" id="s283_sa472"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Rag guanine nucleotide exchange factor HUGO:RRAGA, HUGO:RRAGB</body> </html> </notes> <label text="Rag A/B*"/> <bbox w="80.0" h="40.0" x="2915.375" y="775.0"/> </glyph> <glyph class="simple chemical" id="s284_sa473"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="2920.375" y="812.5"/> </glyph> </glyph> <glyph class="complex" id="s510_csa42" compartmentRef="c5_ca5"> <label text="mTORC1"/> <bbox w="100.0" h="180.0" x="2525.375" y="763.5"/> <glyph class="macromolecule" id="s511_sa474"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="2535.375" y="773.5"/> </glyph> <glyph class="macromolecule" id="s512_sa475"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:MTOR mechanistic target of rapamycin (serine/threonine kinase)</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="2535.375" y="823.5"/> <glyph class="state variable" id="_a342d7bb-0b99-4bd6-9fae-bb5bbf97b4b5"> <state value="P" variable="S2448"/> <bbox w="40.0" h="10.0" x="2572.3242" y="818.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s513_sa476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:RPTOR regulatory associated protein of MTOR, complex 1</body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="40.0" x="2535.375" y="873.5"/> </glyph> </glyph> <glyph class="complex" id="s528_csa43" compartmentRef="c2_ca2"> <label text="miR-19a_PTEN"/> <bbox w="100.0" h="120.0" x="4980.0" y="1556.0"/> <glyph class="nucleic acid feature" id="s529_sa477"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTEN phosphatase and tensin homolog</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="4985.0" y="1603.5"/> <glyph class="unit of information" id="_a5506949-6d5f-47f5-9efa-e248ecdbe264"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5020.0" y="1598.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s530_sa478"> <label text="MIR19A"/> <bbox w="90.0" h="25.0" x="4985.0" y="1573.5"/> <glyph class="unit of information" id="_5916105e-9f23-4e6d-8cf1-d958fb1fea07"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5015.0" y="1568.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s527_csa44" compartmentRef="c2_ca2"> <label text="miR-21_PTEN"/> <bbox w="100.0" h="100.0" x="4980.0" y="1444.0"/> <glyph class="nucleic acid feature" id="s525_sa479"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:PTEN phosphatase and tensin homolog</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="4985.0" y="1491.5"/> <glyph class="unit of information" id="_979c1013-ae5a-4291-b61b-a7a7d49cf233"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5020.0" y="1486.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s526_sa480"> <label text="MIR21"/> <bbox w="90.0" h="25.0" x="4985.0" y="1461.5"/> <glyph class="unit of information" id="_2bae3657-2516-4d97-b10c-9d42ecdeaac1"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5015.0" y="1456.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s553_csa45" compartmentRef="c1_ca1"> <label text="Calmodulin/Ca2+"/> <bbox w="100.0" h="110.0" x="713.0" y="226.0"/> <glyph class="simple chemical" id="s554_sa481"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="750.5" y="283.5"/> </glyph> <glyph class="macromolecule" id="s555_sa482"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>calmodulin 1 (phosphorylase kinase, delta) HUGO:CALM1 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="723.0" y="236.0"/> </glyph> </glyph> <glyph class="complex" id="s556_csa46" compartmentRef="c1_ca1"> <label text="Ca2+/CAMK2"/> <bbox w="100.0" h="150.0" x="790.0" y="392.0"/> <glyph class="macromolecule" id="s557_sa483"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>calcium/calmodulin-dependent protein kinase II alpha HUGO:CAMK2A calcium/calmodulin-dependent protein kinase II beta HUGO:CAMK2B calcium/calmodulin-dependent protein kinase II delta HUGO:CAMK2D calcium/calmodulin-dependent protein kinase II gamma HUGO:CAMK2G</body> </html> </notes> <label text="CAMK2*"/> <bbox w="80.0" h="40.0" x="798.0" y="455.0"/> </glyph> <glyph class="macromolecule" id="s558_sa484"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>calmodulin 1 (phosphorylase kinase, delta) HUGO:CALM1 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="800.0" y="402.0"/> </glyph> <glyph class="simple chemical" id="s559_sa485"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="827.5" y="499.5"/> </glyph> </glyph> <glyph class="complex" id="s571_csa47" compartmentRef="c1_ca1"> <label text="Tubulin-α*/Tubulin-β*/Stathmin*"/> <bbox w="100.0" h="180.0" x="3819.0" y="2874.0"/> <glyph class="macromolecule" id="s569_sa486"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>tubulin, alpha 1a HUGO:TUBA1A tubulin, alpha 1b HUGO:TUBA1B tubulin, alpha 1c HUGO:TUBA1C tubulin, alpha 3c HUGO:TUBA3C tubulin, alpha 3d HUGO:TUBA3D tubulin, alpha 3e HUGO:TUBA3E tubulin, alpha 4a HUGO:TUBA4A tubulin, alpha 8 HUGO:TUBA8</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="3829.0" y="2884.0"/> </glyph> <glyph class="macromolecule" id="s570_sa487"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TUBB1 tubulin beta 1 class VI HUGO:TUBB2A tubulin beta 2A class IIa HUGO:TUBB2B tubulin beta 2B class IIb HUGO:TUBB3 tubulin beta 3 class III HUGO:TUBB4A tubulin beta 4A class IVa HUGO:TUBB4B tubulin beta 4B class IVb HUGO:TUBB6 tubulin beta 6 class V HUGO:TUBB7P tubulin beta 7 pseudogene HUGO:TUBB8 tubulin beta 8 class VIII</body> </html> </notes> <label text="Tubulin-β*"/> <bbox w="80.0" h="40.0" x="3829.0" y="2934.0"/> </glyph> <glyph class="macromolecule" id="s572_sa488"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Stathmins family Stathmin 1 HUGO:STMN1 Stathmin 2 HUGO:STMN2 Stathmin 3 HUGO:STMN3 Stathmin 4 HUGO:STMN4</body> </html> </notes> <label text="Stathmin*"/> <bbox w="80.0" h="40.0" x="3829.0" y="2984.0"/> <glyph class="state variable" id="_deae6896-2f58-4380-8844-41f03e7517a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3880.5686" y="2979.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s567_csa48" compartmentRef="c1_ca1"> <label text="Tubulin-α*/Tubulin-β*"/> <bbox w="120.0" h="140.0" x="3989.0" y="2764.0"/> <glyph class="macromolecule" id="s565_sa489"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>tubulin, alpha 1a HUGO:TUBA1A tubulin, alpha 1b HUGO:TUBA1B tubulin, alpha 1c HUGO:TUBA1C tubulin, alpha 3c HUGO:TUBA3C tubulin, alpha 3d HUGO:TUBA3D tubulin, alpha 3e HUGO:TUBA3E tubulin, alpha 4a HUGO:TUBA4A tubulin, alpha 8 HUGO:TUBA8</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="4009.0" y="2774.0"/> </glyph> <glyph class="macromolecule" id="s566_sa490"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:TUBB1 tubulin beta 1 class VI HUGO:TUBB2A tubulin beta 2A class IIa HUGO:TUBB2B tubulin beta 2B class IIb HUGO:TUBB3 tubulin beta 3 class III HUGO:TUBB4A tubulin beta 4A class IVa HUGO:TUBB4B tubulin beta 4B class IVb HUGO:TUBB6 tubulin beta 6 class V HUGO:TUBB7P tubulin beta 7 pseudogene HUGO:TUBB8 tubulin beta 8 class VIII</body> </html> </notes> <label text="Tubulin-β*"/> <bbox w="80.0" h="40.0" x="4009.0" y="2824.0"/> </glyph> </glyph> <glyph class="complex" id="s582_csa49" compartmentRef="c1_ca1"> <label text="(EGF family/EGFR)"/> <bbox w="100.0" h="120.0" x="5182.0" y="2237.0"/> 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id="s586_sa492"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>transforming growth factor, alpha HUGO:TGFA heparin-binding EGF-like growth factor HUGO:HBEGF epidermal growth factor HUGO:EGF</body> </html> </notes> <label text="EGF family*"/> <bbox w="80.0" h="40.0" x="5192.0" y="2247.0"/> </glyph> </glyph> <glyph class="complex" id="s587_csa50" compartmentRef="c1_ca1"> <label text="(EGF family/EGFR)"/> <bbox w="100.0" h="120.0" x="5182.0" y="2410.0"/> <glyph class="macromolecule" id="s589_sa493"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>Receptor tyrosine kinase epidermal growth factor receptor HUGO:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) HUGO:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) HUGO:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) HUGO:ERBB4</body> </html> </notes> <label text="EGFR family*"/> <bbox w="80.0" h="50.0" x="5192.0" y="2465.0"/> <glyph class="state variable" id="_06fea7c9-60a0-4561-9db7-a0056334b177"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5224.5" y="2460.0"/> </glyph> <glyph class="unit of information" id="_e7e49c9f-4957-43b2-95ca-980c859cb9e8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="5209.5" y="2460.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s588_sa494"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>transforming growth factor, alpha HUGO:TGFA heparin-binding EGF-like growth factor HUGO:HBEGF epidermal growth factor HUGO:EGF</body> </html> </notes> <label text="EGF family*"/> <bbox w="80.0" h="40.0" x="5192.0" y="2420.0"/> </glyph> </glyph> <glyph class="complex" id="s624_csa51" compartmentRef="c2_ca2"> <label text="JMJD2C/Histone H3*/LEO1 promoter*"/> <bbox w="150.0" h="160.0" x="1438.0" y="1992.0"/> <glyph class="macromolecule" id="s625_sa495"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>lysine demethylase 4C "jumonji domain containing 2C", "lysine (K)-specific demethylase 4C" HUGO:KDM4C</body> </html> </notes> <label text="JMJD2C*"/> <bbox w="80.0" h="40.0" x="1468.0" y="2002.0"/> </glyph> <glyph class="nucleic acid feature" id="s626_sa496"> <label text="LEO1 promoter*"/> <bbox w="135.0" h="22.5" x="1440.5" y="2100.75"/> </glyph> <glyph class="macromolecule" id="s627_sa497"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>histone cluster 1 H3 family member a HUGO:HIST1H3A histone cluster 1 H3 family member b HUGO:HIST1H3B histone cluster 1 H3 family member c 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histone cluster 1 H3 family member b HUGO:HIST1H3B histone cluster 1 H3 family member c HUGO:HIST1H3C histone cluster 1 H3 family member d HUGO:HIST1H3D histone cluster 1 H3 family member e HUGO:HIST1H3E histone cluster 1 H3 family member f HUGO:HIST1H3F histone cluster 1 H3 family member g HUGO:HIST1H3G histone cluster 1 H3 family member h HUGO:HIST1H3H histone cluster 1 H3 family member i HUGO:HIST1H3I histone cluster 1 H3 family member j HUGO:HIST1H3J histone cluster 1 H3 pseudogene 1 HUGO:HIST1H3PS1</body> </html> </notes> <label text="Histone H3*"/> <bbox w="95.5" h="33.0" x="1489.25" y="1847.5"/> <glyph class="state variable" id="_77f92129-6097-45f8-9272-7d6e77c91935"> <state value="" variable="K9"/> <bbox w="20.0" h="10.0" x="1527.038" y="1842.5"/> </glyph> <glyph class="state variable" id="_7c3d966f-5571-42db-91b6-d99a261dca3a"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1502.4165" y="1842.5"/> </glyph> <glyph class="state variable" 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family member f HUGO:HIST1H3F histone cluster 1 H3 family member g HUGO:HIST1H3G histone cluster 1 H3 family member h HUGO:HIST1H3H histone cluster 1 H3 family member i HUGO:HIST1H3I histone cluster 1 H3 family member j HUGO:HIST1H3J histone cluster 1 H3 pseudogene 1 HUGO:HIST1H3PS1</body> </html> </notes> <label text="Histone H3*"/> <bbox w="101.0" h="36.0" x="1014.5" y="1963.0"/> <glyph class="state variable" id="_b024e242-e75b-405d-994e-3dff4b7cbcd1"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1050.0402" y="1958.0"/> </glyph> <glyph class="state variable" id="_aef77acc-ab9e-4f19-83c5-dad4b94f228c"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1029.2887" y="1958.0"/> </glyph> <glyph class="state variable" id="_4e5eccca-c4cf-4c9c-a6e7-42ce41b39f8d"> <state value="Me" variable="K9"/> <bbox w="30.0" h="10.0" x="1071.3984" y="1958.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s636_csa57" compartmentRef="c2_ca2"> <label text="PAF complex"/> 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text="GGA1"/> <bbox w="80.0" h="40.0" x="4494.0" y="3296.0"/> </glyph> <glyph class="macromolecule" id="s646_sa513"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>ADP ribosylation factor 1 HUGO:ARF1</body> </html> </notes> <label text="ARF1"/> <bbox w="80.0" h="40.0" x="4494.0" y="3236.0"/> </glyph> <glyph class="simple chemical" id="s647_sa514"> <label text="GTP"/> <bbox w="70.0" h="25.0" x="4499.0" y="3273.5"/> </glyph> </glyph> <glyph class="complex" id="s698_csa60" compartmentRef="c1_ca1"> <label text="VEGFR2/VEGF*"/> <bbox w="100.0" h="120.0" x="5181.0" y="2681.0"/> <glyph class="macromolecule" id="s701_sa518"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>HUGO:KDR Kinase insert domain receptor</body> </html> </notes> <label text="VEGFR2"/> <bbox w="80.0" h="50.0" x="5190.727" y="2692.182"/> <glyph class="state variable" id="_ae4e3a64-c501-4976-bb7a-b785a987fd98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5185.727" y="2701.8267"/> </glyph> <glyph class="unit of information" id="_15ce403e-759a-42a2-96e2-a05316ad2c96"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="5208.227" y="2687.182"/> </glyph> </glyph> <glyph class="macromolecule" id="s702_sa519"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner"> <head> <title/> </head> <body>vascular endothelial growth factor A HUGO:VEGFA vascular endothelial growth factor B HUGO:VEGFB vascular endothelial growth factor C HUGO:VEGFC vascular endothelial growth factor D HUGO:VEGFD</body> </html> </notes> <label text="VEGF*"/> <bbox w="80.0" h="40.0" x="5188.727" y="2742.182"/> </glyph> </glyph> <glyph class="complex" id="s703_csa61" compartmentRef="c1_ca1"> <label text="VEGFR2/VEGF*"/> <bbox w="100.0" h="120.0" x="5189.727" y="2870.0908"/> 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