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</head> <body>Identifiers_begin: Irradiation x-rays and gamma rays Damage types are uracil, abasic site, 8-oxiguqnine, singne strand break, double strand break, intra strand crosslink Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ MODULE:TLS MODULE:SSA Maps_Modules_end References_begin: http://dnatraffic.ibb.waw.pl/classification/dna_damages PMID:22258607, PMID:19267553, PMID:18256616 For BER PMID:19414382, PMID:21204762, PMID:20832016, PMID:17892593 For C_NHEJ PMID:20691907, PMID:23012265, PMID:21785230 FOR HR PMID:20723763 For A_NHEJ PMID:19357644 References_end</body> </html> </notes> <label text="IR"/> <bbox w="70.0" h="25.0" x="5150.7695" y="5435.5"/> </glyph> <glyph class="unspecified entity" id="s3231_sa1492" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ultraviolet light or radiation (UV-A and UV-B) Damage types are bulky adducts, 6-4 phosphoproducts, cyclobutane pyrimidinr dimer (CPD), pyrimidine dimer, thymidine dimer. Causes direct damage, NER gap, stalled transcription and stalled replication fork or indirect damage by formation of free radicals Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:C_NHEJ MODULE:FANCONI MODULE:TLS MODULE:DR Maps_Modules_end References_begin: http://dnatraffic.ibb.waw.pl/classification/dna_damages PMID:22258607, PMID:19267553, PMID:18256616 For NER PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527 For C_NHEJ PMID:17293412, PMID:15367581 FOR HR PMID:21646340, PMID:22987150, PMID:22860035 For TLS PMID:22521143 For Fanconi PMID:17145857 References_end</body> </html> </notes> <label text="UV"/> <bbox w="70.0" h="25.0" x="5412.7695" y="5432.5"/> </glyph> <glyph class="simple chemical" id="s185_sa24" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="3'ddR5P"/> <bbox w="70.0" h="25.0" x="1746.269" y="7341.5"/> </glyph> <glyph class="simple chemical" id="s34_sa4" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="5'dRP"/> <bbox w="70.0" h="25.0" x="2225.269" y="7325.5"/> </glyph> <glyph class="simple chemical" id="s3250_sa1538" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Nitrogen mustards Cyclophosphamide Mechlorethamine or mustine (HN2) (trade name Mustardgen) Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Nitrosoureas Carmustine Lomustine Streptozocin Alkyl sulfonates Busulfan Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:NER MODULE:DR MODULE:MMR Maps_Modules_end References_begin: PMID:22237395, PMID:22122467, PMID:21113301, PMID:22911013, PMID:22788764, PMID:22709253 References_end</body> </html> </notes> <label text="Alkylating agents*"/> <bbox w="160.0" h="28.0" x="3518.769" y="5421.0"/> </glyph> <glyph class="simple chemical" id="s3379_sa1591" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Dbait is a short stabilized double stranded DNA molecule mimicking double strand breaks and inducing false DNA damage signaling and DNA repair pathways Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:DR MODULE:C_NHEJ MODULE:A_NHEJ MODULE:TLS Maps_Modules_end References_begin: PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083 References_end</body> </html> </notes> <label text="Dbait*"/> <bbox w="104.0" h="25.0" x="4922.7695" y="5432.5"/> </glyph> <glyph class="simple chemical" id="s3254_sa1542" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Lipid peroxides cause damage similar to reactive oxygen species (ROS) Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:DR Maps_Modules_end References_begin: http://dnatraffic.ibb.waw.pl/classification/dna_damages PMID:22257221, PMID:16909291 References_end</body> </html> </notes> <label text="Lipid peroxides*"/> <bbox w="171.0" h="30.0" x="3840.769" y="5428.5"/> </glyph> <glyph class="simple chemical" id="s106_sa11" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="Modified 2-12 nucl fragment"/> <bbox w="163.0" h="26.0" x="2717.269" y="7568.5"/> </glyph> <glyph class="simple chemical" id="s282_sa40" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="Modified 24-32 nucleotides fragment"/> <bbox w="214.0" h="30.0" x="428.7412" y="7364.5"/> </glyph> <glyph class="simple chemical" id="s3233_sa1494" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Reactive oxygen species cause base or single strand damage by inducing DNA with oxidized or ring-saturated base or hydrolysed base Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:DR MODULE:NER Maps_Modules_end References_begin: http://dnatraffic.ibb.waw.pl/classification/dna_damages PMID:22258607, PMID:19267553, PMID:18256616 For BER PMID:23249296, PMID:22122466, PMID:20510258, PMID:21251944 ROS activate NER for repating intrastrand crosslink PMID:22581771 ROS activate NER for bulky adducts PMID:18189366 References_end</body> </html> </notes> <label text="ROS"/> <bbox w="88.0" h="29.0" x="4172.436" y="5424.5"/> </glyph> <glyph class="nucleic acid feature" id="s2530_sa1146" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB, HGNC:12849, ENTREZ:7529 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG, HGNC:12852, ENTREZ:7532 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH, HGNC:12853, ENTREZ:7533 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE, HGNC:12851, ENTREZ:7531 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ, HGNC:12854, ENTREZ:10971 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ, HGNC:12855, ENTREZ:7534 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="90.0" h="25.0" x="7899.7686" y="2072.0"/> <glyph class="unit of information" id="_125e282d-7e49-46ad-a654-1415ec707110"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7934.7686" y="2067.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1542_sa286" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1813.9694"/> <glyph class="unit of information" id="_0e65cc41-7ae9-4705-8971-d9555405b48a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1808.9694"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2591_sa1188" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog (yeast) HUGO:BUB1, HGNC:1148, ENTREZ:699 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:9790499 References_end</body> </html> </notes> <label text="BUB1"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1168.8932"/> <glyph class="unit of information" id="_c1453e14-7bcd-47d1-a824-68a9c57da3b0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1163.8932"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2291_sa931" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="90.0" h="25.0" x="7912.2686" y="781.8473"/> <glyph class="unit of information" id="_ee830b26-095b-4a63-84cc-e6932fc30d51"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="776.8473"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2511_sa1132" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 25 homolog A (S. pombe) HUGO:CDC25A, HGNC:1725, ENTREZ:993 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25A"/> <bbox w="90.0" h="25.0" x="7912.2686" y="910.8626"/> <glyph class="unit of information" id="_64083c35-fb6b-4046-835f-9dfe742fd316"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="905.8626"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s3064_sa1417" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1684.9541"/> <glyph class="unit of information" id="_b56ada1d-6b22-4b5a-b6b3-fb70adf19322"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1679.9541"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2183_sa841" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A, HGNC:1784, ENTREZ:1026 cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B, HGNC:1785, ENTREZ:1027 cyclin-dependent kinase inhibitor 1C (p57, Kip2) HUGO:CDKN1C, HGNC:1786, ENTREZ:1028 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CIP/KIP*"/> <bbox w="90.0" h="25.0" x="7897.015" y="394.8014"/> <glyph class="unit of information" id="_26680ef2-ff6d-480e-b648-ddcc71208ca9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7932.015" y="389.8014"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2069_sa362" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin A1 HUGO:CCNA1, HGNC:1577, ENTREZ:8900 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinA1*"/> <bbox w="90.0" h="25.0" x="7897.015" y="136.77094"/> <glyph class="unit of information" id="_5144e093-b0aa-4902-ba17-bd279528b859"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7932.015" y="131.77094"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2185_sa843" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin B1 HUGO:CCNB1, HGNC:1579, ENTREZ:891 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="90.0" h="25.0" x="7912.2686" y="652.83185"/> <glyph class="unit of information" id="_3e4b02c7-c889-40ca-963d-15c286199002"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="647.83185"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2505_sa1127" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="90.0" h="25.0" x="7897.015" y="523.81665"/> <glyph class="unit of information" id="_ca24ef57-0442-46fd-9e4c-90bcf289255c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7932.015" y="518.81665"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2055_sa358" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1, HGNC:1589, ENTREZ:898 cyclin E2 HUGO:CCNE2, HGNC:1590, ENTREZ:9134 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="88.0" h="27.0" x="7899.015" y="45.755585"/> <glyph class="unit of information" id="_f4daf992-1849-419b-93c4-c6be352cf48e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7933.015" y="40.755585"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1538_sa282" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 2, 48kDa HUGO:DDB2, HGNC:2718, ENTREZ:1643 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB2"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1555.939"/> <glyph class="unit of information" id="_ecc46450-267e-46e9-a385-abb735c6d6ee"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1550.939"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1536_sa280" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Growth arrest and DNA-damage-inducible, alpha HUGO:GADD45A, HGNC:4095, ENTREZ:1647 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:NER Maps_Modules_end References_begin: PMID:19004803 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1297.9084"/> <glyph class="unit of information" id="_9968c8cd-eb34-4b20-a5db-e6fd2c3fdafc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1292.9084"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2503_sa1125" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), p16INK4A, p19ARF HUGO:CDKN2A, HGNC:1787, ENTREZ:1029 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), p15INK4b HUGO:CDKN2B, HGNC:1788, ENTREZ:1030 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), INK4C HUGO:CDKN2C, HGNC:1789, ENTREZ:1031 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4), INK4D HUGO:CDKN2D, NC:1790, ENTREZ:1032 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="INK4*"/> <bbox w="90.0" h="25.0" x="7897.015" y="265.78616"/> <glyph class="unit of information" id="_0d50e87a-89f4-477b-9c15-ffc20e2c2d14"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7932.015" y="260.78616"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s2588_sa1185" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD2 mitotic arrest deficient-like 1 (yeast) HUGO:MAD2L1, HGNC:6763, ENTREZ:4085 MAD2 mitotic arrest deficient-like 2 (yeast) HUGO:MAD2L2, HGNC:6764, ENTREZ:10459 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:8824189, PMID:17498870, PMID:15024386, PMID:18022367 References_end</body> </html> </notes> <label text="MAD2*"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1039.8779"/> <glyph class="unit of information" id="_91d263d8-ae90-461f-b104-613c07aec476"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1034.8779"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1292_sa247" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 1 HUGO:USP1, HGNC:12607, ENTREZ:7398 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="USP1"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1942.9846"/> <glyph class="unit of information" id="_8a0406ea-177a-4037-8cc5-8107c81b0611"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1937.9846"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s1540_sa284" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group C HUGO:XPC, HGNC:12816, ENTREZ:7508 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPC"/> <bbox w="90.0" h="25.0" x="7912.2686" y="1426.9236"/> <glyph class="unit of information" id="_8bd957fa-9bee-4e23-85b4-fc3c0f8f946b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7947.2686" y="1421.9236"/> </glyph> </glyph> <glyph class="macromolecule" id="s2515_sa1134" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB, HGNC:12849, ENTREZ:7529, UNIPROT:P31946 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG, HGNC:12852, ENTREZ:7532, UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH, HGNC:12853, ENTREZ:7533, UNIPROT:Q04917 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE, HGNC:12851, ENTREZ:7531, UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ, HGNC:12854, ENTREZ:10971, UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ, HGNC:12855, ENTREZ:7534, UNIPROT:Q6NUR9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4913.7695" y="1674.5"/> </glyph> <glyph class="macromolecule" id="s3204_sa1482" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Alkylated DNA repair protein alkB homolog HUGO:ALKBH2, HGNC:32487, ENTREZ:121642, UNIPROT:Q6NS38 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:DR Maps_Modules_end References_begin: PMID:12486230, PMID:16174769, PMID:18519673, PMID:19153659, PMID:19290481 References_end</body> </html> </notes> <label text="ABH2*"/> <bbox w="80.0" h="40.0" x="10105.769" y="6507.5"/> </glyph> <glyph class="macromolecule" id="s3205_sa1483" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: alkB, alkylation repair homolog 3 HUGO:ALKBH3, HGNC:30141, ENTREZ:221120, UNIPROT:Q96Q83 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:DR Maps_Modules_end References_begin: PMID:12486230, PMID:16174769, PMID:18519673, PMID:19153659, PMID:19290481 References_end</body> </html> </notes> <label text="ABH3*"/> <bbox w="80.0" h="40.0" x="10105.769" y="6563.5"/> </glyph> <glyph class="macromolecule" id="s2486_sa62" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: c-abl oncogene 1, receptor tyrosine kinase HUGO:ABL1, HGNC:76, ENTREZ:25, UNIPROT:P00519 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:21435002, PMID:21199784, PMID:21051857 References_end</body> </html> </notes> <label text="ABL1"/> <bbox w="80.0" h="40.0" x="2887.537" y="2300.668"/> <glyph class="state variable" id="_9a41e1d3-29e0-43a0-a0c7-c895f18e483b"> <state value="P" variable="S465"/> <bbox w="35.0" h="10.0" x="2870.037" y="2315.6362"/> </glyph> </glyph> <glyph class="macromolecule" id="s1509_sa59" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: c-abl oncogene 1, receptor tyrosine kinase HUGO:ABL1, HGNC:76, ENTREZ:25, UNIPROT:P00519 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:21435002, PMID:21199784, PMID:21051857 References_end</body> </html> </notes> <label text="ABL1"/> <bbox w="80.0" h="40.0" x="2889.287" y="2165.0"/> <glyph class="state variable" id="_41d1046c-0fe4-405d-bbc4-f77808408fc2"> <state value="" variable="S465"/> <bbox w="30.0" h="10.0" x="2874.287" y="2179.9683"/> </glyph> </glyph> <glyph class="macromolecule" id="s2536_sa1155" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1, HGNC:391, ENTREZ:207, UNIPROT:P31749 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2, HGNC:392, ENTREZ:208, UNIPROT:P31751 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) HUGO:AKT3, HGNC:393, ENTREZ:10000, UNIPROT:Q9Y243 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="3678.769" y="2247.5"/> </glyph> <glyph class="macromolecule" id="s2300_sa953" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC1, HGNC:19988, ENTREZ:64682, UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="3002.281" y="1078.02"/> </glyph> <glyph class="macromolecule" id="s2316_sa963" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="3172.281" y="1121.0201"/> </glyph> <glyph class="macromolecule" id="s2315_sa961" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="3172.281" y="1163.02"/> </glyph> <glyph class="macromolecule" id="s2314_sa962" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="3172.281" y="1206.02"/> </glyph> <glyph class="macromolecule" id="s2299_sa954" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="3002.281" y="1121.0201"/> </glyph> <glyph class="macromolecule" id="s2306_sa958" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 homolog (S. cerevisiae) HUGO:CDC27, HGNC:1728, ENTREZ:996, UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="3002.281" y="1163.02"/> </glyph> <glyph class="macromolecule" id="s2307_sa960" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="3002.281" y="1206.02"/> </glyph> <glyph class="macromolecule" id="s2308_sa956" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="3087.281" y="1078.02"/> </glyph> <glyph class="macromolecule" id="s2309_sa955" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="3087.281" y="1120.0201"/> </glyph> <glyph class="macromolecule" id="s2312_sa957" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="3087.281" y="1163.02"/> </glyph> <glyph class="macromolecule" id="s2313_sa959" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="3087.281" y="1206.02"/> </glyph> <glyph class="macromolecule" id="s3372_sa26" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: APEX nuclease (multifunctional DNA repair enzyme) 1 HUGO:APEX1, ENTREZ:328, UNIPROT:P27695 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 HUGO:APEX2, ENTREZ:27301, UNIPROT:Q9UBZ4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: Apyrimidinic endonucleases, APE PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362 For Phosphorylation by CK2 PMID:20955519, PMID:9407949 Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death PMID:23110144, PMID:22455312 CDK5 and MDM2 activate APE for shift to BER activity PMID:21727086, PMID:21922195 References_end</body> </html> </notes> <label text="APE*"/> <bbox w="80.0" h="40.0" x="2256.769" y="7212.5"/> <glyph class="state variable" id="_dd98540a-2bbd-4535-b1c0-3c1fa0b0e856"> <state value="P" variable="Thr233"/> <bbox w="45.0" h="10.0" x="2283.5623" y="7207.5"/> </glyph> <glyph class="state variable" id="_6fa17485-284f-4534-ba55-2ad86ce9350a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2251.769" y="7221.4185"/> </glyph> <glyph class="state variable" id="_ef7093b6-cf83-421c-97aa-968ad57e434d"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="2326.769" y="7221.7676"/> </glyph> </glyph> <glyph class="macromolecule" id="s3184_sa1465" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: APEX nuclease (multifunctional DNA repair enzyme) 1 HUGO:APEX1, ENTREZ:328, UNIPROT:P27695 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 HUGO:APEX2, ENTREZ:27301, UNIPROT:Q9UBZ4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: Apyrimidinic endonucleases, APE PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362 For Phosphorylation by CK2 PMID:20955519, PMID:9407949 Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death PMID:23110144, PMID:22455312 CDK5 and MDM2 activate APE for shift to BER activity PMID:21727086, PMID:21922195 References_end</body> </html> </notes> <label text="APE*"/> <bbox w="80.0" h="40.0" x="2437.9358" y="7204.3335"/> <glyph class="state variable" id="_5893b7b6-5884-47cf-bc9c-6c963fa9c9db"> <state value="" variable="Thr233"/> <bbox w="40.0" h="10.0" x="2467.229" y="7199.3335"/> </glyph> <glyph class="state variable" id="_d669f9bf-7431-4479-8179-b77fd24bab70"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2430.4358" y="7213.252"/> </glyph> <glyph class="state variable" id="_13216a47-ecf7-4a17-8cd5-e4a70d275d39"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2512.9358" y="7213.601"/> </glyph> </glyph> <glyph class="macromolecule" id="s149_sa1585" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: APEX nuclease (multifunctional DNA repair enzyme) 1 HUGO:APEX1, ENTREZ:328, UNIPROT:P27695 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 HUGO:APEX2, ENTREZ:27301, UNIPROT:Q9UBZ4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: Apyrimidinic endonucleases, APE PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362 For Phosphorylation by CK2 PMID:20955519, PMID:9407949 Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death PMID:23110144, PMID:22455312 CDK5 and MDM2 activate APE for shift to BER activity PMID:21727086, PMID:21922195 References_end</body> </html> </notes> <label text="APE*"/> <bbox w="80.0" h="40.0" x="2204.4673" y="7096.5"/> <glyph class="state variable" id="_8b02478f-c594-4860-beac-e9d4c7ff013a"> <state value="" variable="Thr233"/> <bbox w="40.0" h="10.0" x="2233.7605" y="7091.5"/> </glyph> <glyph class="state variable" id="_0b4e76e1-71f9-4df8-8e08-9273c7c4e5ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2199.4673" y="7105.4185"/> </glyph> <glyph class="state variable" id="_cf53bbca-cb44-4a04-bd9c-cd581f7531ff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2279.4673" y="7105.7676"/> </glyph> </glyph> <glyph class="macromolecule" id="s3405_sa1599" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: aprataxin and PNKP like factor HUGO:APLF HGNC:28724 ENTREZ:200558 UNIPROT:Q8IW19 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ References_end</body> </html> </notes> <label text="APLF"/> <bbox w="80.0" h="40.0" x="5916.7686" y="7872.5005"/> </glyph> <glyph class="macromolecule" id="s608_sa63" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: DDR by ATM PMID:23847781 PMID:17303408, PMID:16163361, PMID:15964794 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:11877377 References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="4626.518" y="2968.3225"/> <glyph class="state variable" id="_cf77abf9-dbb1-4aec-8066-0a7857a3583e"> <state value="P" variable="S367"/> <bbox w="35.0" h="10.0" x="4623.166" y="2963.3225"/> </glyph> <glyph class="state variable" id="_8ae96027-681f-443d-8135-0a5d95b2478b"> <state value="P" variable="S1981"/> <bbox w="40.0" h="10.0" x="4606.518" y="2983.2908"/> </glyph> <glyph class="state variable" id="_7fc24f7b-1cbf-43fb-bfa3-70c8bae8191f"> <state value="P" variable="S1893"/> <bbox w="40.0" h="10.0" x="4606.518" y="2998.8528"/> </glyph> </glyph> <glyph class="macromolecule" id="s599_sa55" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: DDR by ATM PMID:23847781 PMID:17303408, PMID:16163361, PMID:15964794 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:11877377 References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="4628.517" y="2707.0"/> <glyph class="state variable" id="_68d91a9a-830a-4131-a16c-34079ebbad33"> <state value="" variable="S367"/> <bbox w="30.0" h="10.0" x="4627.665" y="2702.0"/> </glyph> <glyph class="state variable" id="_b75f6c36-aa92-416d-9c04-9f97c69fd536"> <state value="" variable="S1981"/> <bbox w="35.0" h="10.0" x="4611.017" y="2721.9683"/> </glyph> <glyph class="state variable" id="_778ef27a-11ab-4aeb-a124-a172a1721114"> <state value="" variable="S1893"/> <bbox w="35.0" h="10.0" x="4611.017" y="2737.5303"/> </glyph> </glyph> <glyph class="macromolecule" id="s626_sa66" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="3918.019" y="2973.6682"/> <glyph class="state variable" id="_4f0cd013-2864-4a7b-b81f-43684c047ff4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3910.519" y="2988.6682"/> </glyph> </glyph> <glyph class="macromolecule" id="s600_sa56" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="3917.769" y="2707.0"/> <glyph class="state variable" id="_84304b1c-3d98-4dfa-b60d-732caed25674"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3912.769" y="2722.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1511_sa60" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5033.2695" y="2981.6682"/> </glyph> <glyph class="macromolecule" id="s2449_sa1044" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: aurora kinase B HUGO:AURKB, HGNC:11390, ENTREZ:9212, UNIPROT:Q96GD4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:14767480 Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="AURKB"/> <bbox w="80.0" h="40.0" x="3234.769" y="4824.5"/> <glyph class="state variable" id="_a8316ca8-3dac-4945-bd42-c2f170f38035"> <state value="P" variable="T232"/> <bbox w="35.0" h="10.0" x="3217.269" y="4839.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2399_sa1095" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: aurora kinase B HUGO:AURKB, HGNC:11390, ENTREZ:9212, UNIPROT:Q96GD4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:14767480 Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="AURKB"/> <bbox w="80.0" h="40.0" x="3226.5918" y="4927.6387"/> <glyph class="state variable" id="_63e35265-f6d9-4cdf-89dc-59df1fc96c85"> <state value="" variable="T232"/> <bbox w="30.0" h="10.0" x="3211.5918" y="4942.6387"/> </glyph> </glyph> <glyph class="macromolecule" id="s916_sa139" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1C, HGNC:17642, ENTREZ:64421, UNIPROT:Q5JSS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495 References_end</body> </html> </notes> <label text="Artemis*"/> <bbox w="80.0" h="40.0" x="5950.2686" y="7444.4077"/> <glyph class="state variable" id="_9c848fd6-c5ac-4698-b289-d2b90b7ad9c5"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="5956.364" y="7439.4077"/> </glyph> <glyph class="state variable" id="_7eec0366-2ecd-4976-86fa-737e8a4e9a3c"> <state value="P" variable="S645"/> <bbox w="35.0" h="10.0" x="5933.261" y="7439.4077"/> </glyph> <glyph class="state variable" id="_b17628fe-38f9-41bb-a266-853a6bbe10da"> <state value="P" variable="S518"/> <bbox w="35.0" h="10.0" x="5989.718" y="7439.4077"/> </glyph> <glyph class="state variable" id="_e763c56b-d01d-44b0-901f-4f04af6d0740"> <state value="P" variable="S516"/> <bbox w="35.0" h="10.0" x="5972.8003" y="7439.4077"/> </glyph> </glyph> <glyph class="macromolecule" id="s915_sa138" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1C, HGNC:17642, ENTREZ:64421, UNIPROT:Q5JSS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495 References_end</body> </html> </notes> <label text="Artemis*"/> <bbox w="80.0" h="40.0" x="6118.0205" y="7444.4077"/> <glyph class="state variable" id="_19c36823-e0f1-46e4-93a5-71458e817bcc"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="6126.6157" y="7439.4077"/> </glyph> <glyph class="state variable" id="_810fc45e-775f-4063-99b6-959fdacf264c"> <state value="" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Bloom syndrome, RecQ helicase-like HUGO:BLM, HGNC:1058, ENTREZ:641, UNIPROT:P54132 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: For HR pathway, PMID:22657828 PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 BLM in telomere maintenance PMID:23253856 Resolving stalled replication fork BLM inhibits A_NHEJ (alt_NHEJ): PMID:24089143 PMID:24095737 References_end</body> </html> </notes> <label text="BLM"/> <bbox w="80.0" h="40.0" x="7343.6064" y="5990.0"/> </glyph> <glyph class="macromolecule" id="s3225_sa1487" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BMI1 polycomb ring finger oncogene HUGO:BMI1, HGNC:1066, ENTREZ:648, UNIPROT:P35226 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:17936558, PMID:21678481, PMID:21685941, PMID:21383063 References_end</body> </html> </notes> <label text="BMI1"/> <bbox w="80.0" h="40.0" x="3546.1536" y="2169.1924"/> <glyph class="state variable" id="_1910d459-aba4-4c32-bfbe-ad70e6d39ea7"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3538.6536" y="2184.1924"/> </glyph> </glyph> <glyph class="macromolecule" id="s2534_sa1156" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BMI1 polycomb ring finger oncogene HUGO:BMI1, HGNC:1066, ENTREZ:648, UNIPROT:P35226 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:17936558, PMID:21678481, PMID:21685941, PMID:21383063 References_end</body> </html> </notes> <label text="BMI1"/> <bbox w="80.0" h="40.0" x="3548.8174" y="2329.4668"/> <glyph class="state variable" id="_7e6c189c-8f6d-4784-9a2f-419ac201b8e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3543.8174" y="2344.4668"/> </glyph> </glyph> <glyph class="macromolecule" id="s3243_sa1531" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="8160.2686" y="7043.0"/> <glyph class="state variable" id="_a6b33e23-9934-4356-9c18-656536300101"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="8222.769" y="7043.2393"/> </glyph> <glyph class="state variable" id="_b62b5b45-9fba-4eaf-89b6-1e1882b034ce"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="8200.131" y="7038.0"/> </glyph> <glyph class="state variable" id="_fadb05e7-bda7-4001-8c28-d62666b8ca94"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="8180.02" y="7038.0"/> </glyph> <glyph class="state variable" id="_dc07275b-5f14-40b3-ab32-f397e1b13d55"> <state value="" variable="S1423"/> 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MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7965.621" y="6936.7783"/> <glyph class="state variable" id="_2e561520-5cb5-4606-a2af-6be038257235"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="8028.121" y="6937.0176"/> </glyph> <glyph class="state variable" id="_ae3f7c1b-82fc-4de3-b550-5fd48dd670cc"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="8005.483" y="6931.7783"/> </glyph> <glyph class="state variable" id="_2db929b6-b3d7-4f7c-a967-51b0ef906fbf"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="7985.3726" y="6931.7783"/> </glyph> <glyph class="state variable" id="_fe5cd7dd-9561-4e33-b4ca-8e7ce9043779"> <state 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Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7824.031" y="7046.0"/> <glyph class="state variable" id="_a4a0c1e6-393c-4f42-a536-3addc2b6c595"> <state value="P" variable="S1387"/> <bbox w="40.0" h="10.0" x="7884.031" y="7046.2393"/> </glyph> <glyph class="state variable" id="_42e666b9-b1af-48ec-a089-1de5ab10f812"> <state value="P" variable="S988"/> <bbox w="35.0" h="10.0" x="7861.3926" y="7041.0"/> </glyph> <glyph class="state variable" id="_df1be241-62a4-4fd9-a149-b1c507e7be6e"> <state value="P" variable="S1497"/> <bbox w="40.0" h="10.0" x="7841.282" y="7041.0"/> </glyph> <glyph class="state variable" 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ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7964.1816" y="7043.198"/> <glyph class="state variable" id="_6ef81df7-4632-4356-8aab-20d4f21f8b10"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="8026.6816" y="7043.4375"/> </glyph> <glyph class="state variable" id="_37db451d-0f16-425f-bfc5-bc356667ca80"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="8004.0435" y="7038.198"/> </glyph> <glyph class="state variable" id="_89cb0290-0fc9-40c7-be9d-45d6a0886d64"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="7983.933" y="7038.198"/> </glyph> 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onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7346.6064" y="5854.0"/> </glyph> <glyph class="macromolecule" id="s3060_sa1414" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCT-repeat inhibitor of TERT expression 1 (BRIT1), Microcephalin(MCPH1) HUGO:MCPH1, HGNC:6954, ENTREZ:79648, UNIPROT:Q8NEM0 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:20376879, PMID:15220350, PMID:19525936, PMID:18660752 References_end</body> </html> </notes> <label text="BRIT1*"/> <bbox w="80.0" h="40.0" x="7557.1064" y="6864.5"/> </glyph> <glyph class="macromolecule" id="s2456_sa1043" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog (yeast) HUGO:BUB1, HGNC:1148, ENTREZ:699, UNIPROT:O43683 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:9790499 References_end</body> </html> </notes> <label text="BUB1"/> <bbox w="80.0" h="40.0" x="4069.769" y="4676.4995"/> <glyph class="state variable" id="_b3b4c05c-e1be-4dfc-8a65-159e74ad7b5d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4075.8213" y="4671.4995"/> </glyph> </glyph> <glyph class="macromolecule" id="s2398_sa1100" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog (yeast) HUGO:BUB1, HGNC:1148, ENTREZ:699, UNIPROT:O43683 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:9790499 References_end</body> </html> </notes> <label text="BUB1"/> <bbox w="80.0" h="40.0" x="3957.0088" y="4678.317"/> <glyph class="state variable" id="_b7780022-afeb-4c97-84db-5bca3c4c74bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3965.561" y="4673.317"/> </glyph> </glyph> <glyph class="macromolecule" id="s2405_sa1049" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 3 homolog (yeast) HUGO:BUB3, HGNC:1151, ENTREZ:9184, UNIPROT:O43684 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with BUB1 and BUBR1* PMID:19182530, PMID:11535616 References_end</body> </html> </notes> <label text="BUB3"/> <bbox w="80.0" h="40.0" x="4064.769" y="4479.5"/> </glyph> <glyph class="macromolecule" id="s2402_sa1047" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog beta (yeast) HUGO:BUB1B, HGNC:1149, ENTREZ:701, UNIPROT:Q59HH6 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3 PMID:17376779, PMID:10477750, PMID:19503101, PMID:11535616, PMID:15592459 As a part of MCC complex, act as pseudo-substrate of APC complex PMID:19154723 References_end</body> </html> </notes> <label text="BUBR1*"/> <bbox w="80.0" h="40.0" x="4064.769" y="4525.5"/> </glyph> <glyph class="macromolecule" id="s2407_sa1050" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle associated 8, Borealin HUGO:CDCA8, HGNC:14629, ENTREZ:55143, UNIPROT:Q53HL2 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="Borealin*"/> <bbox w="80.0" h="40.0" x="3508.0796" y="4829.072"/> <glyph class="state variable" id="_ea0bcccf-9f1f-4085-93b2-39d798c06065"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3500.5796" y="4844.072"/> </glyph> </glyph> <glyph class="macromolecule" id="s2400_sa1045" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle associated 8, Borealin HUGO:CDCA8, HGNC:14629, ENTREZ:55143, UNIPROT:Q53HL2 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="Borealin*"/> <bbox w="80.0" h="40.0" x="3505.769" y="4923.5"/> <glyph class="state variable" id="_4661d000-980f-426a-88cc-8322604e3e94"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3500.769" y="4938.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3039_sa1398" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cullin-associated and neddylation-dissociated 1 HUGO:CAND1, HGNC:30688, ENTREZ:55832, UNIPROT:Q9H0G2 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15537541, PMID:12504025, PMID:12504026 References_end</body> </html> </notes> <label text="CAND1"/> <bbox w="80.0" h="40.0" x="3030.269" y="766.5"/> </glyph> <glyph class="macromolecule" id="s2490_sa1112" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CREB binding protein, CBP HUGO:CREBBP, HGNC:2348, ENTREZ:1387, UNIPROT:Q92793 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:20144767 References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="4252.7695" y="2277.5"/> </glyph> <glyph class="macromolecule" id="s3227_sa1489" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CDC14 cell division cycle 14 homolog A (S. cerevisiae) HUGO:CDC14A, HGNC:1718, ENTREZ:8556, UNIPROT:Q9UNH5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:20144767 References_end</body> </html> </notes> <label text="CDC14A"/> <bbox w="80.0" h="40.0" x="4077.3145" y="1416.0454"/> <glyph class="state variable" id="_1718e291-42b5-4677-a1d3-01a68bba58c1"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4069.8145" y="1431.0454"/> </glyph> </glyph> <glyph class="macromolecule" id="s2477_sa1107" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CDC14 cell division cycle 14 homolog A (S. cerevisiae) HUGO:CDC14A, HGNC:1718, ENTREZ:8556, UNIPROT:Q9UNH5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:20144767 References_end</body> </html> </notes> <label text="CDC14A"/> <bbox w="80.0" h="40.0" x="3919.107" y="1405.3818"/> <glyph class="state variable" id="_1d418bb3-634e-4183-ac45-af0dc0a79915"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3914.107" y="1420.3818"/> </glyph> </glyph> <glyph class="macromolecule" id="s2_sa307" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991, UNIPROT:Q12834 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="80.0" h="40.0" x="3495.769" y="1023.87506"/> <glyph class="state variable" id="_9c67315f-d185-42b7-b1fc-9bf982e79b24"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3490.769" y="1038.875"/> </glyph> </glyph> <glyph class="macromolecule" id="s1956_sa345" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 25 homolog A (S. pombe) HUGO:CDC25A, HGNC:1725, ENTREZ:993, UNIPROT:P30304 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25A"/> <bbox w="80.0" h="40.0" x="4623.545" y="1499.7695"/> <glyph class="state variable" id="_7b7b49ee-d09b-4a44-8028-bfd19d8fc0fe"> <state value="" variable="S178"/> <bbox w="30.0" h="10.0" x="4608.545" y="1511.0043"/> </glyph> <glyph class="state variable" id="_9a2b300a-15b4-4433-8d76-c2f8d6cf87ae"> <state value="" variable="S76"/> <bbox w="25.0" h="10.0" x="4653.33" y="1494.7695"/> </glyph> <glyph class="state variable" id="_91add3aa-548a-4f2d-b531-95a6d8d45fb4"> <state value="" variable="S279"/> <bbox w="30.0" h="10.0" x="4608.545" y="1518.8645"/> </glyph> <glyph class="state variable" id="_d5fe79be-7e00-4d19-8d3c-cf53881ce8d4"> <state value="" variable="S124"/> <bbox w="30.0" h="10.0" x="4608.545" y="1501.121"/> </glyph> <glyph class="state variable" id="_8cd0a28b-e55c-4546-b61a-421c1bbdf8f5"> <state value="P" variable="S18"/> <bbox w="30.0" h="10.0" x="4672.0513" y="1494.7695"/> </glyph> <glyph class="state variable" 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<label text="CDC25A"/> <bbox w="80.0" h="40.0" x="4620.307" y="1264.4922"/> <glyph class="state variable" id="_6b3fdefc-0dce-48e1-8e43-8cc1193718af"> <state value="P" variable="S178"/> <bbox w="35.0" h="10.0" x="4602.807" y="1275.7269"/> </glyph> <glyph class="state variable" id="_728eaa42-fa63-4abf-8d2d-65b8332da948"> <state value="P" variable="S76"/> <bbox w="30.0" h="10.0" x="4647.5923" y="1259.4922"/> </glyph> <glyph class="state variable" id="_c9d45063-9854-409a-941b-7804d732c260"> <state value="P" variable="S279"/> <bbox w="35.0" h="10.0" x="4602.807" y="1283.5872"/> </glyph> <glyph class="state variable" id="_7d001d2a-570d-472a-bc0c-c46db0669aa0"> <state value="P" variable="S124"/> <bbox w="35.0" h="10.0" x="4602.807" y="1265.8436"/> </glyph> <glyph class="state variable" id="_fa7bb005-cc2d-4760-b427-3dc669e3fdd8"> <state value="" variable="S18"/> <bbox w="25.0" h="10.0" x="4671.3135" y="1259.4922"/> </glyph> <glyph class="state variable" 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<label text="CDC25A"/> <bbox w="80.0" h="40.0" x="4619.269" y="1376.2617"/> <glyph class="state variable" id="_f2f081d4-5e60-4cb7-8341-ccf8ccd492f8"> <state value="" variable="S178"/> <bbox w="30.0" h="10.0" x="4604.269" y="1387.4965"/> </glyph> <glyph class="state variable" id="_3989f068-0489-42a8-bee9-da2fca34c49f"> <state value="" variable="S76"/> <bbox w="25.0" h="10.0" x="4649.054" y="1371.2617"/> </glyph> <glyph class="state variable" id="_7e862550-b2e1-4b2d-90d7-0ef525c18869"> <state value="" variable="S279"/> <bbox w="30.0" h="10.0" x="4604.269" y="1395.3567"/> </glyph> <glyph class="state variable" id="_469449da-e2ab-4224-9565-2b3a49cfbde7"> <state value="" variable="S124"/> <bbox w="30.0" h="10.0" x="4604.269" y="1377.6132"/> </glyph> <glyph class="state variable" id="_868d2f2c-cebf-41da-970b-46f5f44817e9"> <state value="" variable="S18"/> <bbox w="25.0" h="10.0" x="4670.2754" y="1371.2617"/> </glyph> <glyph class="state variable" id="_3693342e-ce2c-485a-92e1-9d85e1ea1e21"> 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division cycle 25 homolog B (S. pombe) HUGO:CDC25B, HGNC:1726, ENTREZ:994, UNIPROT:P30305 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25B"/> <bbox w="80.0" h="40.0" x="4897.742" y="1264.4922"/> <glyph class="state variable" id="_694b90e0-e5b5-4278-933c-56920ab42a7b"> <state value="P" variable="S230"/> <bbox w="35.0" h="10.0" x="4880.242" y="1279.4603"/> </glyph> <glyph class="state variable" id="_a0be773f-0f0f-42a7-bcb8-e42689012c1c"> <state value="" variable="S353"/> <bbox w="30.0" h="10.0" x="4939.2217" y="1259.4922"/> </glyph> <glyph class="state variable" id="_9a03c12c-4631-4031-abe6-7612abf5e9d3"> <state value="P" variable="S323"/> <bbox w="35.0" h="10.0" x="4880.242" y="1290.377"/> </glyph> <glyph class="state variable" 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Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25C"/> <bbox w="80.0" h="40.0" x="5212.1953" y="1372.2617"/> <glyph class="state variable" id="_dafe5e2f-3488-412f-8e6d-4c65b304cc84"> <state value="" variable="S191"/> <bbox w="30.0" h="10.0" x="5197.1953" y="1387.6299"/> </glyph> <glyph class="state variable" id="_08985b59-1b3c-4b11-9e9d-a7c4bb8d0f2f"> <state value="" variable="S216"/> <bbox w="30.0" h="10.0" x="5254.1445" y="1367.2617"/> </glyph> <glyph class="state variable" id="_e5b7a5ce-cc31-4167-9157-77bd9b7286e9"> <state value="" variable="S214"/> <bbox w="30.0" h="10.0" x="5198.0815" y="1407.2617"/> </glyph> <glyph class="state variable" id="_5007a2ca-62e6-43a9-b61b-81acaef7e19d"> <state value="" variable="S198"/> <bbox w="30.0" h="10.0" x="5197.1953" y="1374.5078"/> </glyph> </glyph> <glyph class="macromolecule" id="s1927_sa348" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 25 homolog C (S. pombe) HUGO:CDC25C, HGNC:1727, ENTREZ:995, UNIPROT:P30307 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25C"/> <bbox w="80.0" h="40.0" x="5216.949" y="1496.919"/> <glyph class="state variable" id="_96d0edd2-f95a-4ee2-860d-203da98f6cd1"> <state value="P" variable="S191"/> <bbox w="35.0" h="10.0" x="5199.449" y="1512.2871"/> </glyph> <glyph class="state variable" 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PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25C"/> <bbox w="80.0" h="40.0" x="5209.2695" y="1264.4922"/> <glyph class="state variable" id="_5d83e6d0-f317-4083-8aea-d5f82f11deb9"> <state value="" variable="S191"/> <bbox w="30.0" h="10.0" x="5194.2695" y="1279.8604"/> </glyph> <glyph class="state variable" id="_ec31f885-784c-4911-96b5-bcdf12a65f05"> <state value="P" variable="S216"/> <bbox w="35.0" h="10.0" x="5248.7188" y="1259.4922"/> </glyph> <glyph class="state variable" id="_674e8092-d06b-4a73-9137-b683b993a5c1"> <state value="" variable="S214"/> <bbox w="30.0" h="10.0" x="5195.156" y="1299.4922"/> </glyph> <glyph class="state variable" id="_274169d0-b16f-4f1f-9a67-505a0010887b"> <state value="" variable="S198"/> <bbox w="30.0" h="10.0" x="5194.2695" y="1266.7383"/> </glyph> </glyph> <glyph class="macromolecule" id="s2190_sa847" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 45 homolog (S. cerevisiae) HUGO:CDC45, HGNC:1739, ENTREZ:8318, UNIPROT:O75419 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17608804, PMID:17887956, PMID:12185086, PMID:10882098, PMID:21527023, PMID:21406556, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC45"/> <bbox w="80.0" h="40.0" x="5613.7695" y="832.5"/> </glyph> <glyph class="macromolecule" id="s2205_sa862" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 6 homolog (S. cerevisiae) HUGO:CDC6, HGNC:1744, ENTREZ:990, UNIPROT:Q99741 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC6"/> <bbox w="80.0" h="40.0" x="5702.769" y="831.5"/> </glyph> <glyph class="macromolecule" id="s2238_sa903" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 7 homolog (S. cerevisiae) HUGO:CDC7, HGNC:1745, ENTREZ:8317, UNIPROT:O00311 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17018296, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC7"/> <bbox w="80.0" h="40.0" x="6111.7686" y="792.5"/> </glyph> <glyph class="macromolecule" id="s924_sa321" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1, HGNC:1722, ENTREZ:983, UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="5299.0195" y="1713.875"/> <glyph class="state variable" id="_0eb3e739-9783-4256-b21a-f72db8ba1ecc"> <state value="" variable="T161"/> <bbox w="30.0" h="10.0" x="5364.0195" y="1728.475"/> </glyph> <glyph class="state variable" id="_f1fa24aa-2098-4767-ace6-6045e2aa390a"> <state value="" variable="Y14/15"/> <bbox w="40.0" h="10.0" x="5335.9688" y="1708.875"/> </glyph> <glyph class="state variable" id="_da11bbf3-29f4-4a58-89b4-65040e14c495"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5294.0195" y="1728.8431"/> </glyph> </glyph> <glyph class="macromolecule" id="s42_sa310" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2, HGNC:1771, ENTREZ:1017, UNIPROT:P24941 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17303408, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="3616.644" y="86.87503"/> <glyph class="state variable" id="_50f84285-0e95-403e-abb6-532cadfed00a"> <state value="" variable="Y14/15"/> <bbox w="40.0" h="10.0" x="3616.4695" y="81.87503"/> </glyph> <glyph class="state variable" id="_b099fdbf-44ad-4a26-952e-e5b1e8172c16"> <state value="" variable="T160"/> <bbox w="30.0" h="10.0" x="3601.644" y="101.84318"/> </glyph> </glyph> <glyph class="macromolecule" id="s3371_sa1584" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 5 HUGO:CDK5 HGNC:1774 ENTREZ:1020 UNIPROT:Q00535 Identifiers_end Maps_Modules_begin: MODULE:BER MODULE:DNA_REPAIR Maps_Modules_end References_begin: Triple phosphorylation by CDK5 inhibits PARP1 PMID:21922195 Stabilisation of USP1 by phosphorylaton by CDK5 PMID:23589330 References_end</body> </html> </notes> <label text="CDK5"/> <bbox w="80.0" h="40.0" x="2342.769" y="7127.5"/> </glyph> <glyph class="macromolecule" id="s1815_sa334" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 7 HUGO:CDK7, HGNC:1778, ENTREZ:1022, UNIPROT:P50613 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 CDK7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II References_end</body> </html> </notes> <label text="CDK7"/> <bbox w="80.0" h="40.0" x="4788.519" y="357.5"/> </glyph> <glyph class="macromolecule" id="s2206_sa863" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromatin licensing and DNA replication factor 1 HUGO:CDT1, HGNC:24576, ENTREZ:81620, UNIPROT:Q9H211 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDT1"/> <bbox w="80.0" h="40.0" x="5789.7686" y="832.5"/> </glyph> <glyph class="macromolecule" id="s324_sa38" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Centrin, EF-hand protein, 2 HUGO:CETN2, HGNC:1867, ENTREZ:1069, UNIPROT:P41208 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CETN2"/> <bbox w="80.0" h="40.0" x="1629.8798" y="6825.5674"/> </glyph> <glyph class="macromolecule" id="s1514_sa58" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111, UNIPROT:O14757 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <bbox w="80.0" h="40.0" x="5376.2656" y="2707.0"/> <glyph class="state variable" id="_dc967958-fa7a-4916-b670-7cbc9d30c15d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5371.2656" y="2722.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1517_sa112" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK2 checkpoint homolog (S. pombe) HUGO:CHEK2, HGNC:16627, ENTREZ:11200, Q9UGF0 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:15810020, PMID:18566216, PMID:17464182 References_end</body> </html> </notes> <label text="CHEK2"/> <bbox w="80.0" h="40.0" x="5799.7627" y="2707.0"/> <glyph class="state variable" id="_f56d29e5-4e29-45fb-93d7-e9addc8c5ca7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5794.7627" y="2722.4597"/> </glyph> </glyph> <glyph class="macromolecule" id="s1516_sa111" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK2 checkpoint homolog (S. pombe) HUGO:CHEK2, HGNC:16627, ENTREZ:11200, Q9UGF0 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:15810020, PMID:18566216, PMID:17464182 References_end</body> </html> </notes> <label text="CHEK2"/> <bbox w="80.0" h="40.0" x="5809.2686" y="2973.6682"/> <glyph class="state variable" id="_4b303b4d-8acd-418a-be9e-597e062ac42b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5801.7686" y="2989.128"/> </glyph> </glyph> <glyph class="macromolecule" id="s3148_sa1430" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) HUGO:CHTF18, HGNC:18435, ENTREZ:63922, UNIPROT:Q8WVB6 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:12930902, PMID:20227374 References_end</body> </html> </notes> <label text="CHTF18"/> <bbox w="80.0" h="40.0" x="1220.322" y="7743.95"/> </glyph> <glyph class="macromolecule" id="s2179_sa311" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A, HGNC:1784, ENTREZ:1026, UNIPROT:P38936 cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B, HGNC:1785, ENTREZ:1027, UNIPROT:P46527 cyclin-dependent kinase inhibitor 1C (p57, Kip2) HUGO:CDKN1C, HGNC:1786, ENTREZ:1028, UNIPROT:P49918 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CIP1_KIP1*"/> <bbox w="80.0" h="40.0" x="4619.644" y="205.87506"/> </glyph> <glyph class="macromolecule" id="s3183_sa1464" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 2, alpha 1 polypeptide HUGO:CSNK2A1, HGNC:2457, ENTREZ:1457, UNIPROT:P68400 casein kinase 2, alpha prime polypeptide HUGO:CSNK2A2, HGNC:2459, ENTREZ:1459, UNIPROT:P19784 casein kinase 2, beta polypeptide HUGO:CSNK2B, HGNC:2460, ENTREZ:1460, UNIPROT:P67870 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:NER MODULE:HR Maps_Modules_end References_begin: PMID:20471329, PMID:15066279, PMID:18583988, PMID:18583988, PMID:20533398, PMID:19118383, PMID:21118972, PMID:20507565, PMID:21576760, PMID:21592330 References_end</body> </html> </notes> <label text="CK2*"/> <bbox w="80.0" h="40.0" x="2376.769" y="6964.5"/> <glyph class="state variable" id="_07ba624f-1c9b-43e5-84c1-138c8f046911"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2369.269" y="6979.4683"/> </glyph> </glyph> <glyph class="macromolecule" id="s2979_sa350" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="5758.0186" y="3242.5002"/> <glyph class="state variable" id="_ea38537b-121f-4ec3-a16b-67f5b157435f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5830.5186" y="3249.216"/> </glyph> </glyph> <glyph class="macromolecule" id="s1932_sa1358" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="5937.4395" y="3246.501"/> <glyph class="state variable" id="_d47a4ac8-0339-422d-8864-891dc3f1a2ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6012.4395" y="3253.2168"/> </glyph> </glyph> <glyph class="macromolecule" id="s400_sa46" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cockayne syndrome 1 (classical) excision repair cross-complementing rodent repair deficiency, complementation group 8 HUGO:ERCC8, HGNC:3439, ENTREZ:1161, UNIPROT:Q13216 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CSA*"/> <bbox w="80.0" h="40.0" x="307.28467" y="6593.0566"/> </glyph> <glyph class="macromolecule" id="s399_sa47" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cockayne syndrome B protein Excision repair cross-complementing rodent repair deficiency, complementation group 6 HUGO:ERCC6, HGNC:3438, ENTREZ:2074, UNIPROT:Q03468 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CSB*"/> <bbox w="80.0" h="40.0" x="271.74146" y="6784.0"/> </glyph> <glyph class="macromolecule" id="s2514_sa1133" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1, HGNC:2494, ENTREZ:1487, UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2, HGNC:2495, ENTREZ:1488, UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21681822, PMID:20964627, PMID:19506021, PMID:19216735 References_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="4211.5625" y="2565.0771"/> <glyph class="state variable" id="_6246e5fc-c851-4013-a99a-9112ba95a75c"> <state value="P" variable="S181"/> <bbox w="35.0" h="10.0" x="4245.0312" y="2560.0771"/> </glyph> <glyph class="state variable" id="_ce0f83e7-96bf-4f5f-8dcd-e0e12e91d9c7"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="4272.922" y="2560.0771"/> </glyph> <glyph class="state variable" id="_8a8cd89b-2318-4a7a-b62e-91389f66fe1a"> <state value="P" variable="S185"/> <bbox w="35.0" h="10.0" x="4227.9277" y="2560.0771"/> </glyph> <glyph class="state variable" id="_3e4d241f-9be5-4cc4-a1ce-5d0584147e79"> <state value="P" variable="T179"/> <bbox w="35.0" h="10.0" x="4212.711" y="2560.0771"/> </glyph> </glyph> <glyph class="macromolecule" id="s712_sa95" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1, HGNC:2494, ENTREZ:1487, UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2, HGNC:2495, ENTREZ:1488, UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21681822, PMID:20964627, PMID:19506021, PMID:19216735 References_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="4364.7773" y="2456.5505"/> <glyph class="state variable" id="_35385a97-1c72-4915-82e7-e9ec89694c2c"> <state value="" variable="S181"/> <bbox w="30.0" h="10.0" x="4400.746" y="2451.5505"/> </glyph> <glyph class="state variable" id="_916bb422-b5eb-4c8b-9faf-1b4dfb373e44"> <state value="P" variable="S422"/> <bbox w="35.0" h="10.0" x="4423.6367" y="2451.5505"/> </glyph> <glyph class="state variable" id="_0364c28f-dac8-4d81-b099-e93b39a28b4e"> <state value="" variable="S185"/> <bbox w="30.0" h="10.0" x="4383.6426" y="2451.5505"/> </glyph> <glyph class="state variable" id="_13de289d-f33b-4016-82a6-bf8a1b5022c2"> <state value="" variable="T179"/> <bbox w="30.0" h="10.0" x="4368.426" y="2451.5505"/> </glyph> </glyph> <glyph class="macromolecule" id="s711_sa94" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1, HGNC:2494, ENTREZ:1487, UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2, HGNC:2495, ENTREZ:1488, UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21681822, PMID:20964627, PMID:19506021, PMID:19216735 References_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="4209.2695" y="2453.9998"/> <glyph class="state variable" id="_4fb177f2-34ec-4e8b-b7bf-72917977152f"> <state value="" variable="S181"/> <bbox w="30.0" h="10.0" x="4245.2383" y="2448.9998"/> </glyph> <glyph class="state variable" id="_ac149a43-0fd3-455f-a100-c67c40f7c265"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="4270.629" y="2448.9998"/> </glyph> <glyph class="state variable" id="_2f4eca1e-d7ca-4c98-84b4-f671250ced7d"> <state value="" variable="S185"/> <bbox w="30.0" h="10.0" x="4228.135" y="2448.9998"/> </glyph> <glyph class="state variable" id="_b0f7f995-0eb7-41c6-a5bb-b5077b212e16"> <state value="" variable="T179"/> <bbox w="30.0" h="10.0" x="4212.918" y="2448.9998"/> </glyph> </glyph> <glyph class="macromolecule" id="s1093_sa146" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="6083.2686" y="2150.0"/> <glyph class="state variable" id="_2a1500ca-69b8-453d-b01e-e3c42ee7cdf4"> <state value="P" variable="S372"/> <bbox w="35.0" h="10.0" x="6089.364" y="2145.0"/> </glyph> <glyph class="state variable" id="_b51f7da5-1934-4787-aa90-4dafbeb2a7e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6078.2686" y="2165.0"/> </glyph> <glyph class="state variable" id="_b8c58258-4f1f-46c4-ab37-b072d6e140b1"> <state value="P" variable="S267"/> <bbox w="35.0" h="10.0" x="6065.7686" y="2175.3718"/> </glyph> <glyph class="state variable" id="_113aa9a2-da26-4588-bd88-d6afff8a34c2"> <state value="P" variable="T847"/> <bbox w="35.0" h="10.0" x="6065.7686" y="2151.851"/> </glyph> <glyph class="state variable" id="_0f3b6348-5178-42e0-8b65-52f54cf9b709"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="6087.137" y="2185.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1091_sa159" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="6083.2686" y="2331.0"/> <glyph class="state variable" id="_e8bee4c6-35b2-4a81-bc1b-eebabec90723"> <state value="P" variable="S372"/> <bbox w="35.0" h="10.0" x="6089.364" y="2326.0"/> </glyph> <glyph class="state variable" id="_3362485a-3412-4cfb-94cb-998fbb579146"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6078.2686" y="2346.0"/> </glyph> <glyph class="state variable" id="_f4d79be1-c1bd-4302-a3af-e1f6dd1e7fe9"> <state value="P" variable="S267"/> <bbox w="35.0" h="10.0" x="6065.7686" y="2356.3718"/> </glyph> <glyph class="state variable" id="_2f479759-3a79-4887-839c-6cff465c8cca"> <state value="P" variable="T847"/> <bbox w="35.0" h="10.0" x="6065.7686" y="2332.851"/> </glyph> <glyph class="state variable" id="_d9e0f4ee-c566-4042-9ba4-339df4efcc46"> <state value="Ub" variable="BRCA1-dep"/> <bbox w="65.0" h="10.0" x="6082.137" y="2366.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s949_sa150" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="5896.2686" y="2337.0"/> <glyph class="state variable" id="_93bc8a0c-8520-431e-923c-0448238be39c"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="5904.864" y="2332.0"/> </glyph> <glyph class="state variable" id="_fee0fddc-07de-4741-bee4-5c750b39ed4f"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5886.2686" y="2352.0"/> </glyph> <glyph class="state variable" id="_6e23c45b-4e90-4b29-a5c2-33c8d46aa955"> <state value="" variable="S267"/> <bbox w="30.0" h="10.0" x="5881.2686" y="2362.3718"/> </glyph> <glyph class="state variable" id="_67857a4b-3c22-4c77-8fa4-8ade722aa0c4"> <state value="" variable="T847"/> <bbox w="30.0" h="10.0" x="5881.2686" y="2338.851"/> </glyph> <glyph class="state variable" id="_eb1f964c-b5a3-4eeb-af3c-b05539e5b2bd"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="5900.137" y="2372.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s929_sa145" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="5896.0186" y="2150.0"/> <glyph class="state variable" id="_ab9e67e7-0177-4317-8a67-52160dd0e417"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="5904.614" y="2145.0"/> </glyph> <glyph class="state variable" id="_45822367-cfd6-4985-bc1f-005a90221fe2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5891.0186" y="2165.0"/> </glyph> <glyph class="state variable" id="_d328ce5b-a05f-4883-a649-56a2073f0af3"> <state value="" variable="S267"/> <bbox w="30.0" h="10.0" x="5881.0186" y="2175.3718"/> </glyph> <glyph class="state variable" id="_55d9cd45-4939-4775-b314-ea9d0924c71b"> <state value="" variable="T847"/> <bbox w="30.0" h="10.0" x="5881.0186" y="2151.851"/> </glyph> <glyph class="state variable" id="_6f672cc0-1612-4ba3-a2bc-d14a773a6ebb"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="5899.887" y="2185.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1135_sa218" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cullin 1 HUGO:CUL1, HGNC:2551, ENTREZ:8454, UNIPROT:Q13616 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: Regulates Fanconi pathway in cell cycle dependent manner PMID:19686080, PMID:19622404, PMID:18931676 For checkpoint PMID:15459660 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="3030.019" y="658.24994"/> </glyph> <glyph class="macromolecule" id="s3036_sa1395" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cullin 4A HUGO:CUL4A, HGNC:2554, ENTREZ:8451, UNIPROT:Q13619 Cullin 4B HUGO:CUL4B, HGNC:2555, ENTREZ:8450, UNIPROT:Q13620 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CUL4*"/> <bbox w="80.0" h="40.0" x="308.2954" y="6356.536"/> <glyph class="state variable" id="_528509f8-f316-4d9e-a641-e34bfa1374aa"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="298.2954" y="6371.536"/> </glyph> </glyph> <glyph class="macromolecule" id="s327_sa44" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cullin 4A HUGO:CUL4A, HGNC:2554, ENTREZ:8451, UNIPROT:Q13619 Cullin 4B HUGO:CUL4B, HGNC:2555, ENTREZ:8450, UNIPROT:Q13620 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CUL4*"/> <bbox w="80.0" h="40.0" x="311.28467" y="6483.312"/> <glyph class="state variable" id="_78d86175-8242-4366-80e9-37c450fd7254"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="306.28467" y="6498.312"/> </glyph> </glyph> <glyph class="macromolecule" id="s5_sa309" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin A1 HUGO:CCNA1, HGNC:1577, ENTREZ:8900, UNIPROT:P78396 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinA1*"/> <bbox w="80.0" h="40.0" x="3612.144" y="204.87506"/> </glyph> <glyph class="macromolecule" id="s1957_sa308" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin B1 HUGO:CCNB1, HGNC:1579, ENTREZ:891, UNIPROT:P14635 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="80.0" h="40.0" x="5299.7695" y="1771.8749"/> </glyph> <glyph class="macromolecule" id="s2050_sa355" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="3662.1333" y="748.4908"/> <glyph class="state variable" id="_e8b4a5ad-9d37-46ee-8bc8-671241987aa5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3654.6333" y="763.4908"/> </glyph> </glyph> <glyph class="macromolecule" id="s1948_sa313" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="3663.769" y="660.1363"/> <glyph class="state variable" id="_ea1fdf9c-e87c-4f60-b968-b455c0a047d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3658.769" y="675.1363"/> </glyph> </glyph> <glyph class="macromolecule" id="s2070_sa320" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1, HGNC:1589, ENTREZ:898, UNIPROT:P24864 cyclin E2 HUGO:CCNE2, HGNC:1590, ENTREZ:9134, UNIPROT:O96020 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="3612.019" y="33.375"/> </glyph> <glyph class="macromolecule" id="s1904_sa343" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CyclinH HUGO:CCNH, HGNC:1594, ENTREZ:902, UNIPROT:P51946 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery: PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="CyclinH*"/> <bbox w="80.0" h="40.0" x="4788.7017" y="407.964"/> </glyph> <glyph class="macromolecule" id="s2240_sa907" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DBF4 homolog (S. cerevisiae) HUGO:DBF4, HGNC:17364, ENTREZ:10926, UNIPROT:Q9UBU7 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17018296, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="DBF4"/> <bbox w="80.0" h="40.0" x="6111.538" y="853.52856"/> </glyph> <glyph class="macromolecule" id="s328_sa45" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 1, 127kDa, XPE, p48 HUGO:DDB1, HGNC:2717, ENTREZ:1642, UNIPROT:Q16531 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:1570337, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB1"/> <bbox w="80.0" h="40.0" x="307.28467" y="6535.184"/> </glyph> <glyph class="macromolecule" id="s329_sa42" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 2, 48kDa HUGO:DDB2, HGNC:2718, ENTREZ:1643, UNIPROT:Q92466 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB2"/> <bbox w="80.0" h="40.0" x="1629.2843" y="6645.5674"/> </glyph> <glyph class="macromolecule" id="s3196_sa1475" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="6219.298" y="7387.3823"/> <glyph class="state variable" id="_98940f0a-48cf-4a8f-86a8-a46b079cee5a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6211.798" y="7402.3823"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s912_sa125" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="5923.2686" y="7387.4077"/> <glyph class="unit of information" id="_0725c6cf-e2bd-4ac2-9326-68d724f5e0ec"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5953.2686" y="7382.4077"/> </glyph> <glyph class="state variable" id="_0505a81f-3ac3-462e-b832-e425bfcf3b6f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5918.2686" y="7402.4077"/> </glyph> </glyph> <glyph class="macromolecule" id="s1499_sa276" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA replication helicase 2 homolog (yeast) HUGO:DNA2, HGNC:2939, ENTREZ:1763, UNIPROT:P51530 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19473888 References_end</body> </html> </notes> <label text="DNA2"/> <bbox w="80.0" h="40.0" x="7092.7686" y="6411.0"/> </glyph> <glyph class="macromolecule" id="s3389_sa180" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: split hand/foot malformation (ectrodactyly) type 1 HUGO:SHFM1, HGNC:10845 ENTREZ:7979, UNIPROT:P60896 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="DSS1*"/> <bbox w="80.0" h="40.0" x="7756.4443" y="6951.0"/> </glyph> <glyph class="macromolecule" id="s80_sa326" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cadherin 1, type 1, E-cadherin (epithelial) HUGO:CDH1, HGNC:1748, ENTREZ:999, UNIPROT:P12830 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="80.0" h="40.0" x="3480.269" y="1388.375"/> <glyph class="state variable" id="_d16f2cae-93f6-4c61-809d-0dd4c30bf665"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3475.269" y="1403.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s77_sa324" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1, HGNC:3113, ENTREZ:1869, UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="4618.644" y="821.375"/> <glyph class="state variable" id="_dc443ec9-c9ee-448f-89e0-597ef4c8b7d2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4691.144" y="836.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s13_sa316" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1, HGNC:3113, ENTREZ:1869, UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="4615.644" y="893.375"/> <glyph class="state variable" id="_1cd693ae-15f0-4283-ade1-cd52c85a1b34"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4690.644" y="908.375"/> </glyph> </glyph> <glyph class="macromolecule" id="s1972_sa315" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 4, p107/p130-binding HUGO:E2F4, HGNC:3118, ENTREZ:1874, UNIPROT:Q16254 E2F transcription factor 5, p130-binding HUGO:E2F5, HGNC:3119, ENTREZ:1875, UNIPROT:Q15329 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F4_5*"/> <bbox w="80.0" h="40.0" x="4789.769" y="669.87494"/> </glyph> <glyph class="macromolecule" id="s1064_sa188" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: essential meiotic endonuclease 1 homolog 1 (S. pombe) HUGO:EME1, HGNC:24965, ENTREZ:146956, UNIPROT:Q96AY2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="EME1"/> <bbox w="80.0" h="40.0" x="7427.6064" y="8226.999"/> </glyph> <glyph class="macromolecule" id="s2297_sa936" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: F-box protein 5 HUGO:FBXO5, HGNC:13584, ENTREZ:26271, UNIPROT:Q9UKT4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="EMI1*"/> <bbox w="80.0" h="40.0" x="4180.5938" y="1333.5"/> <glyph class="state variable" id="_bf9679a6-fff7-41c0-9c44-8b6d72ffc463"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4173.0938" y="1348.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2296_sa935" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: F-box protein 5 HUGO:FBXO5, HGNC:13584, ENTREZ:26271, UNIPROT:Q9UKT4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="EMI1*"/> <bbox w="80.0" h="40.0" x="4043.769" y="1333.5"/> <glyph class="state variable" id="_8e642a14-d247-4373-a244-795bbf0f49a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4038.769" y="1348.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s232_sa37" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) HUGO:ERCC1, HGNC:3433, ENTREZ:2067, UNIPROT:P07992 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G, PMID:11900249 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="ERCC1"/> <bbox w="80.0" h="40.0" x="1062.8796" y="7126.568"/> </glyph> <glyph class="macromolecule" id="s2476_sa1102" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase 1 HUGO:MAPK1, HGNC:6871, ENTREZ:5594, UNIPROT:P28482 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:21196257, PMID:21196179 References_end</body> </html> </notes> <label text="ERK2*"/> <bbox w="80.0" h="40.0" x="3682.769" y="4810.5"/> </glyph> <glyph class="macromolecule" id="s1502_sa109" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: exonuclease 1 HUGO:EXO1, HGNC:3511, ENTREZ:9156, UNIPROT:Q9UQ84 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:14676842, PMID:15474417, PMID:18756267, PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:19490890, PMID:11438669, PMID:20019063, PMID:18048416 References_end</body> </html> </notes> <label text="EXO1"/> <bbox w="80.0" h="40.0" x="7516.999" y="6045.86"/> <glyph class="state variable" id="_bc9f37d1-5bc9-4041-b290-b22a4033630d"> <state value="P" variable="S372"/> <bbox w="35.0" h="10.0" x="7499.499" y="6077.129"/> </glyph> <glyph class="state variable" id="_9d9ac42b-8249-4d27-8186-82e7993afcbc"> <state value="P" variable="S692"/> <bbox w="35.0" h="10.0" x="7556.448" y="6040.86"/> </glyph> <glyph class="state variable" id="_36f3c856-7f15-4c7a-b432-e514308ed590"> <state value="P" variable="S587"/> <bbox w="35.0" h="10.0" x="7499.499" y="6058.853"/> </glyph> <glyph class="state variable" id="_ed8dac43-1b6a-49da-ac2a-a52ed9a4729e"> <state value="P" variable="S567"/> <bbox w="35.0" h="10.0" x="7499.499" y="6044.8657"/> </glyph> </glyph> <glyph class="macromolecule" id="s578_sa54" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: exonuclease 1 HUGO:EXO1, HGNC:3511, ENTREZ:9156, UNIPROT:Q9UQ84 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:14676842, PMID:15474417, PMID:18756267, PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:19490890, PMID:11438669, PMID:20019063, PMID:18048416 References_end</body> </html> </notes> <label text="EXO1"/> <bbox w="80.0" h="40.0" x="7337.7686" y="6043.0"/> <glyph class="state variable" id="_6711152e-433d-4aa5-b597-a7697a552ee5"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="7322.7686" y="6074.269"/> </glyph> <glyph class="state variable" id="_eea78a81-8a30-47b2-b23c-00c138438b8c"> <state value="" variable="S692"/> <bbox w="30.0" h="10.0" x="7379.718" y="6038.0"/> </glyph> <glyph class="state variable" id="_72ffed9e-667e-4dde-96d4-34026091d6f8"> <state value="" variable="S587"/> <bbox w="30.0" h="10.0" x="7322.7686" y="6055.993"/> </glyph> <glyph class="state variable" id="_d4dcdaf2-b4aa-4be2-944b-04c4aa2c77f3"> <state value="" variable="S567"/> <bbox w="30.0" h="10.0" x="7322.7686" y="6042.006"/> </glyph> </glyph> <glyph class="macromolecule" id="s1113_sa207" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: some 17 open reading frame 70, FAAP100 HUGO:C17orf70, HGNC:26171, ENTREZ:80233, UNIPROT:Q0VG06 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP100*"/> <bbox w="80.0" h="40.0" x="9316.443" y="7902.89"/> </glyph> <glyph class="macromolecule" id="s3238_sa1500" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 1 open reading frame 86 HUGO:C1orf86, HGNC:26428, ENTREZ:199990, UNIPROT:Q6NZ36 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP20*"/> <bbox w="80.0" h="40.0" x="9032.768" y="7539.5"/> </glyph> <glyph class="macromolecule" id="s1098_sa198" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 19 open reading frame 40, "Fanconi anemia-associated protein, 24 kDa" HUGO:C19orf40, HGNC:28467, ENTREZ:91442, UNIPROT:Q9BTP7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP24*"/> <bbox w="80.0" h="40.0" x="8847.268" y="6442.0"/> </glyph> <glyph class="macromolecule" id="s1276_sa199" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group A HUGO:FANCA, HGNC:3582, ENTREZ:2175, UNIPROT:Q9UEL9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCA"/> <bbox w="80.0" h="40.0" x="9190.521" y="8039.9995"/> <glyph class="state variable" id="_4ae38e9b-08e6-4d7e-8909-cb42565315da"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9263.021" y="8054.9995"/> </glyph> </glyph> <glyph class="macromolecule" id="s1105_sa200" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group B HUGO:FANCB, HGNC:3583, ENTREZ:2187, UNIPROT:Q8NB91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCB"/> <bbox w="80.0" h="40.0" x="9316.443" y="7811.8887"/> </glyph> <glyph class="macromolecule" id="s1106_sa201" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group C HUGO:FANCC, HGNC:3584, ENTREZ:2176, UNIPROT:Q00597 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCC"/> <bbox w="80.0" h="40.0" x="7346.4355" y="5943.8335"/> </glyph> <glyph class="macromolecule" id="s1308_sa254" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="8094.2686" y="6734.159"/> <glyph class="state variable" id="_7153d5d2-3200-457c-9867-3b7f91eb8347"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8089.2686" y="6740.875"/> </glyph> <glyph class="state variable" id="_69612bb7-557b-4f9d-b368-cb4b4de197a6"> <state value="" variable="K561"/> <bbox w="30.0" h="10.0" x="8119.173" y="6769.159"/> </glyph> <glyph class="state variable" id="_b43e2b8f-b708-43d1-9526-98bccff50310"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="8117.6006" y="6729.159"/> </glyph> </glyph> <glyph class="macromolecule" id="s1280_sa222" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7565.165" y="6753.159"/> <glyph class="state variable" id="_cc1e2a32-591a-4793-a36f-7549655b41cb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7557.665" y="6759.875"/> </glyph> <glyph class="state variable" id="_8ab835c0-e1c3-424a-8541-470449aa32fb"> <state value="Ub" variable="K561"/> <bbox w="40.0" h="10.0" x="7585.0693" y="6788.159"/> </glyph> <glyph class="state variable" id="_6584869f-992b-4edf-985f-2fbd56542eab"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="7590.997" y="6748.159"/> </glyph> </glyph> <glyph class="macromolecule" id="s1279_sa202" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7733.4443" y="6754.159"/> <glyph class="state variable" id="_c45fb701-3405-4e83-8e3f-ac38b985d36c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7725.9443" y="6760.875"/> </glyph> <glyph class="state variable" id="_710f7fdd-0e06-4127-9935-3094859c299c"> <state value="" variable="K561"/> <bbox w="30.0" h="10.0" x="7758.3486" y="6789.159"/> </glyph> <glyph class="state variable" id="_93d06421-4cc6-4a65-b77e-7500e4b5e0b3"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="7759.2764" y="6749.159"/> </glyph> </glyph> <glyph class="macromolecule" id="s1107_sa244" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7888.002" y="6754.159"/> <glyph class="state variable" id="_cda4d89d-7cb4-4854-99fb-ef052d65596a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7883.002" y="6760.875"/> </glyph> <glyph class="state variable" id="_203c27c8-4fc4-45a4-9bf2-c9d82f5d31cc"> <state value="" variable="K561"/> <bbox w="30.0" h="10.0" x="7912.9062" y="6789.159"/> </glyph> <glyph class="state variable" id="_aaec9205-91da-48a5-94cd-42da4b47c62a"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="7913.834" y="6749.159"/> </glyph> </glyph> <glyph class="macromolecule" id="s1301_sa203" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group E HUGO:FANCE, HGNC:3586, ENTREZ:2178, UNIPROT:Q9HB96 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCE"/> <bbox w="80.0" h="40.0" x="9312.943" y="7690.8887"/> <glyph class="state variable" id="_470e4821-de0d-46b4-9de5-e105f7a0eef5"> <state value="P" variable="T346"/> <bbox w="35.0" h="10.0" x="9295.443" y="7705.857"/> </glyph> <glyph class="state variable" id="_ffdcb999-a8c9-420d-905d-bbab9d2ca348"> <state value="P" variable="S376"/> <bbox w="35.0" h="10.0" x="9295.443" y="7697.395"/> </glyph> </glyph> <glyph class="macromolecule" id="s1108_sa245" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group E HUGO:FANCE, HGNC:3586, ENTREZ:2178, UNIPROT:Q9HB96 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCE"/> <bbox w="80.0" h="40.0" x="9466.557" y="7694.383"/> <glyph class="state variable" id="_e5b2fa16-68e4-4d41-b4b7-f56f23ef007d"> <state value="" variable="T346"/> <bbox w="30.0" h="10.0" x="9451.557" y="7709.351"/> </glyph> <glyph class="state variable" id="_02f11dda-5da3-4b6c-8650-f6c0e152d241"> <state value="" variable="S376"/> <bbox w="30.0" h="10.0" x="9451.557" y="7700.889"/> </glyph> </glyph> <glyph class="macromolecule" id="s1110_sa205" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group F HUGO:FANCF, HGNC:3587, ENTREZ:2188, UNIPROT:Q9NPI8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCF"/> <bbox w="80.0" h="40.0" x="9316.443" y="7743.8887"/> </glyph> <glyph class="macromolecule" id="s1286_sa208" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group G HUGO:FANCG, HGNC:3588, UNIPROT:O15287 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCG"/> <bbox w="80.0" h="40.0" x="7346.2686" y="5900.0"/> <glyph class="state variable" id="_33ef794b-26ef-4443-b95c-4f88a832433e"> <state value="P" variable="S7"/> <bbox w="25.0" h="10.0" x="7357.364" y="5895.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1114_sa246" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group G HUGO:FANCG, HGNC:3588, UNIPROT:O15287 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCG"/> <bbox w="80.0" h="40.0" x="7540.455" y="5896.2656"/> <glyph class="state variable" id="_5e8784ee-cfdc-41aa-8da9-6733ecd4b8a9"> <state value="" variable="S7"/> <bbox w="20.0" h="10.0" x="7554.0503" y="5891.2656"/> </glyph> </glyph> <glyph class="macromolecule" id="s1185_sa223" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="9140.588" y="7462.3184"/> <glyph class="state variable" id="_b41f0e54-7433-497e-9050-c0024f2547ed"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9213.088" y="7497.3184"/> </glyph> <glyph class="state 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class="state variable" id="_02dcca39-6910-4d0b-8b5c-5b89f953ee6b"> <state value="" variable="K523"/> <bbox w="30.0" h="10.0" x="9344.147" y="7500.8896"/> </glyph> </glyph> <glyph class="macromolecule" id="s1109_sa225" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="9470.588" y="7469.3184"/> <glyph class="state variable" id="_9d423857-f1ef-4ba8-b154-9be28208ab7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9545.588" y="7504.3184"/> </glyph> <glyph class="state variable" id="_0dd7c57f-dfed-4f8c-b365-28a76f3e6e8b"> <state value="" variable="K523"/> <bbox w="30.0" h="10.0" x="9494.292" y="7504.3184"/> </glyph> </glyph> <glyph class="macromolecule" id="s1648_sa298" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ HUGO:BRIP1, HGNC:20473, ENTREZ:83990, UNIPROT:Q9BX63 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:TLS MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism PMID:20173781 References_end</body> </html> </notes> <label text="FANCJ*"/> <bbox w="80.0" h="40.0" x="7344.1064" y="6553.5"/> <glyph class="state variable" id="_4a5e5a4f-4ef8-475d-b909-251eaada026c"> <state value="P" variable="S990"/> <bbox w="35.0" h="10.0" x="7366.638" y="6548.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1116_sa209" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ HUGO:BRIP1, HGNC:20473, ENTREZ:83990, UNIPROT:Q9BX63 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:TLS MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism PMID:20173781 References_end</body> </html> </notes> <label text="FANCJ*"/> <bbox w="80.0" h="40.0" x="7555.3604" y="6550.0"/> <glyph class="state variable" id="_c9302fa6-3012-4a35-ae0d-feec321184a8"> <state value="" variable="S990"/> <bbox w="30.0" h="10.0" x="7580.392" y="6545.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1112_sa206" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group L HUGO:FANCL, HGNC:20748, ENTREZ:55120, UNIPROT:Q9NW38 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: The enzyme possesses E3 ubiquitin ligase activity, the active part in the Fanconi core complex PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCL"/> <bbox w="80.0" h="40.0" x="9316.443" y="7856.8887"/> </glyph> <glyph class="macromolecule" id="s1296_sa250" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group M HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:NER MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 Link between Fanconi and NER PMID:22615860 Fanconi and cross-linking agents PMID:21948210 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCM"/> <bbox w="80.0" h="40.0" x="9022.961" y="6485.05"/> <glyph class="state variable" id="_5dfcd8ec-29bd-4a74-adaa-216a3acccbef"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9055.461" y="6480.05"/> </glyph> </glyph> <glyph class="macromolecule" id="s1101_sa197" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group M HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:NER MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 Link between Fanconi and NER PMID:22615860 Fanconi and cross-linking agents PMID:21948210 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCM"/> <bbox w="80.0" h="40.0" x="8848.268" y="6497.0"/> <glyph class="state variable" id="_af6c7255-6807-4cfb-a611-24e9f11f1642"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8883.268" y="6492.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1117_sa210" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: "Fanconi anemia, complementation group N" HUGO:PALB2, HGNC:26144, ENTREZ:79728, UNIPROT:Q86YC2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:22505525 Parthner and localizer of BRCA2. For Fancony anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="FANCN*"/> <bbox w="80.0" h="40.0" x="7563.246" y="6640.328"/> </glyph> <glyph class="macromolecule" id="s3058_sa10" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: flap structure-specific endonuclease 1 HUGO:FEN1, HGNC:3650, ENTREZ:2237, UNIPROT:P39748 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:23161013 References_end</body> </html> </notes> <label text="FEN1"/> <bbox w="80.0" h="40.0" x="3137.3115" y="7399.067"/> </glyph> <glyph class="macromolecule" id="s3226_sa1488" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1, HGNC:3819, ENTREZ:2308, UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3, HGNC:3821, ENTREZ:2309, UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21613825, PMID:11154281, PMID:17940099, PMID:19380174, PMID:15084260 References_end</body> </html> </notes> <label text="FOXO*"/> <bbox w="80.0" h="40.0" x="3784.7156" y="2171.875"/> <glyph class="state variable" id="_682a8623-e69d-40f0-a4c3-10f957eb83f2"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="3777.2156" y="2186.875"/> </glyph> </glyph> <glyph class="macromolecule" id="s2535_sa1154" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1, HGNC:3819, ENTREZ:2308, UNIPROT:Q12778 forkhead box O3 HUGO:FOXO3, HGNC:3821, ENTREZ:2309, UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21613825, PMID:11154281, PMID:17940099, PMID:19380174, PMID:15084260 References_end</body> </html> </notes> <label text="FOXO*"/> <bbox w="80.0" h="40.0" x="3769.4233" y="2319.1106"/> <glyph class="state variable" id="_1a2a9391-0bbe-4a32-b937-d7723bd80ee1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3764.4233" y="2334.1106"/> </glyph> </glyph> <glyph class="macromolecule" id="s1659_sa278" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Growth arrest and DNA-damage-inducible, alpha HUGO:GADD45A, HGNC:4095, ENTREZ:1647, UNIPROT:P24522 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19004803 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 Role in BER PMID:23485469 References_end</body> </html> </notes> <label text="GADD45A"/> <bbox w="80.0" h="40.0" x="2267.269" y="7388.5107"/> </glyph> <glyph class="macromolecule" id="s1068_sa189" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gen homolog 1, endonuclease (Drosophila) HUGO:GEN1, HGNC:26881, ENTREZ:348654, UNIPROT:Q17RS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="GEN1"/> <bbox w="80.0" h="40.0" x="7201.6064" y="7895.999"/> </glyph> <glyph class="macromolecule" id="s2957_sa1346" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 1 (Psf1 homolog) HUGO:GINS1 HGNC:28980 ENTREZ:9837 UNIPROT:Q14691 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 1 (Psf1 homolog) PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS1"/> <bbox w="80.0" h="40.0" x="6400.4995" y="725.3837"/> </glyph> <glyph class="macromolecule" id="s2958_sa1347" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 2 (Psf2 homolog) HUGO:GINS2 HGNC:24575 ENTREZ:51659 UNIPROT:Q9Y248 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 2 (Psf2 homolog) PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS2"/> <bbox w="80.0" h="40.0" x="6401.4995" y="768.3838"/> </glyph> <glyph class="macromolecule" id="s2959_sa1348" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 3 (Psf3 homolog) HUGO:GINS3 HGNC:25851 ENTREZ:64785 UNIPROT:Q9BRX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 3 (Psf3 homolog) CC phase:S PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS3"/> <bbox w="80.0" h="40.0" x="6484.4995" y="725.3837"/> </glyph> <glyph class="macromolecule" id="s2960_sa1349" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 4 (Sld5 homolog) HUGO:GINS4 HGNC:28226 ENTREZ:84296 UNIPROT:Q9BRT9 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 4 (Sld5 homolog) PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS4"/> <bbox w="80.0" h="40.0" x="6487.4995" y="768.3838"/> </glyph> <glyph class="macromolecule" id="s2049_sa354" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B, HGNC:4617, ENTREZ:2932, UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:10486203, PMID:12969793, PMID:11152665, PMID:18167338, PMID:19757160 References_end</body> </html> </notes> <label text="GSK3β"/> <bbox w="80.0" h="40.0" x="3866.019" y="713.49994"/> </glyph> <glyph class="macromolecule" id="s1482_sa194" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="7827.874" y="7409.801"/> <glyph class="state variable" id="_6a876c63-9462-4dff-a349-f3a9757d013e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7817.874" y="7407.7334"/> </glyph> <glyph class="state variable" id="_86f69797-4bdf-4d54-9438-11a706717bd6"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7810.374" y="7424.801"/> </glyph> </glyph> <glyph class="macromolecule" id="s1480_sa132" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="6271.2686" y="2152.0"/> <glyph class="state variable" id="_f1c46685-1f5e-4592-873c-2cb3f2a8bac6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6266.2686" y="2149.9329"/> </glyph> <glyph class="state variable" id="_567f8456-14bb-47de-9d0d-bc9159c8a8d4"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="6253.7686" y="2167.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1479_sa131" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="6273.7686" y="2329.4077"/> <glyph class="state variable" id="_f4dd882a-eec8-4613-b623-426c698c9c6e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6268.7686" y="2327.3406"/> </glyph> <glyph class="state variable" id="_f226808c-51c6-4592-bb5d-7fb7b6a2f018"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="6258.7686" y="2344.4077"/> </glyph> </glyph> <glyph class="macromolecule" id="s1150_sa219" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TEL2, telomere maintenance 2, homolog (S. cerevisiae) Protein clk-2 homolog , HCLK2 HUGO:TELO2, HGNC:29099, ENTREZ:9894, UNIPROT:Q9Y4R8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 For regulation of Fanconi pathway via cell cycle PMID:18995830, PMID:17384638 For S-phase checkpoint PMID:17384638, PMID:19793801 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 References_end</body> </html> </notes> <label text="HCLK2*"/> <bbox w="80.0" h="40.0" x="5999.2686" y="4070.0"/> </glyph> <glyph class="macromolecule" id="s1420_sa261" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: helicase, POLQ-like HUGO:HELQ, HGNC:18536, ENTREZ:113510, UNIPROT:Q8TDG4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20122407, PMID:20493853, PMID:21195035 References_end</body> </html> </notes> <label text="HEL308*"/> <bbox w="80.0" h="40.0" x="7196.6064" y="7760.0"/> </glyph> <glyph class="macromolecule" id="s1404_sa258" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hairy and enhancer of split 1, (Drosophila) HUGO:HES1, HGNC:5192, ENTREZ:3280, UNIPROT:Q14469 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:8020957, PMID:12535671, PMID:12972610, PMID:18550849, PMID:20832754 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="HES1"/> <bbox w="80.0" h="40.0" x="9039.443" y="7605.8896"/> </glyph> <glyph class="macromolecule" id="s684_sa80" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: homeodomain interacting protein kinase 2 HUGO:HIPK2, HGNC:14402, ENTREZ:28996, UNIPROT:Q9H2X6 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:12851404, PMID:11925430, PMID:19828042, PMID:17349959 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="3604.687" y="2444.3772"/> <glyph class="state variable" id="_6ab2c34d-fcdd-404f-882d-11ab99d6590b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3597.187" y="2459.3772"/> </glyph> </glyph> <glyph class="macromolecule" id="s683_sa79" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: homeodomain interacting protein kinase 2 HUGO:HIPK2, HGNC:14402, ENTREZ:28996, UNIPROT:Q9H2X6 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:12851404, PMID:11925430, PMID:19828042, PMID:17349959 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="3779.269" y="2445.9998"/> <glyph class="state variable" id="_0bfbadd6-0793-4c90-af28-55f468b85d7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3774.269" y="2460.9998"/> </glyph> </glyph> <glyph class="macromolecule" id="s3244_sa1532" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: heat shock protein 90kDa alpha (cytosolic), class B member HUGO:HSPC2, HGNC:5258, ENTREZ:3326, UNIPROT:P08238 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE_REGULATORS MODULE:HR MODULE:FANCONI MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:22869732, PMID:17327415 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="80.0" h="40.0" x="8070.7686" y="7112.5"/> </glyph> <glyph class="macromolecule" id="s2907_sa1299" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUS1 checkpoint homolog (S. pombe) HUGO:HUS1, HGNC:5309, ENTREZ:3364, UNIPROT:O60921 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:9524127, PMID:17493829 References_end</body> </html> </notes> <label text="HUS1"/> <bbox w="80.0" h="40.0" x="3337.3452" y="7041.5"/> </glyph> <glyph class="macromolecule" id="s2450_sa1055" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inner centromere protein antigens 135/155kDa HUGO:INCENP, HGNC:6058, ENTREZ:3619, UNIPROT:Q9NQS7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="INCENP"/> <bbox w="80.0" h="40.0" x="3327.769" y="4824.5"/> <glyph class="state variable" id="_ade62219-9166-478c-ad16-5f5ab82243aa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3320.269" y="4839.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2417_sa1094" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inner centromere protein antigens 135/155kDa HUGO:INCENP, HGNC:6058, ENTREZ:3619, UNIPROT:Q9NQS7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="INCENP"/> <bbox w="80.0" h="40.0" x="3327.5918" y="4925.6387"/> <glyph class="state variable" id="_ff46cebb-e9ce-4d7b-87b0-cb9576ca967d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3322.5918" y="4940.6387"/> </glyph> </glyph> <glyph class="macromolecule" id="s2487_sa312" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), p16INK4A, p19ARF HUGO:CDKN2A, HGNC:1787, ENTREZ:1029, UNIPROT:Q8N726 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), p15INK4b HUGO:CDKN2B, HGNC:1788, ENTREZ:1030, UNIPROT:P42772 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), INK4C HUGO:CDKN2C, HGNC:1789, ENTREZ:1031, UNIPROT:P42773 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4), INK4D HUGO:CDKN2D, NC:1790, ENTREZ:1032, UNIPROT:P55273 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="INK4*"/> <bbox w="80.0" h="40.0" x="3663.769" y="539.87494"/> </glyph> <glyph class="macromolecule" id="s708_sa91" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: itchy E3 ubiquitin protein ligase homolog (mouse) HUGO:ITCH, HGNC:13890, ENTREZ:83737, UNIPROT:Q96J02 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:11318614, PMID:18628966, PMID:10940313, PMID:16861923, PMID:21107885, PMID:21383157 References_end</body> </html> </notes> <label text="ITCH"/> <bbox w="80.0" h="40.0" x="5330.2695" y="4636.9995"/> </glyph> <glyph class="macromolecule" id="s923_sa98" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: JNK1, mitogen-activated protein kinase 8 HUGO:MAPK8, HGNC:6881, ENTREZ:5599, UNIPROT:P45983 JNK2, mitogen-activated protein kinase 9 HUGO:MAPK9, HGNC:6886, ENTREZ:5601, UNIPROT:P45984 JNK3, mitogen-activated protein kinase 10 HUGO:MAPK10, HGNC:6872, ENTREZ:5602, UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21438496, PMID:21372320, PMID:19591900, PMID:17496919, PMID:15611655, PMID:8608010, PMID:20512932, PMID:20220133, PMID:20054826, PMID:19616017 References_end</body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="4107.627" y="2167.5"/> <glyph class="state variable" id="_66e0b1fb-0e20-4c8e-9a6a-9f8c08102a54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4159.1953" y="2162.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s922_sa97" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: JNK1, mitogen-activated protein kinase 8 HUGO:MAPK8, HGNC:6881, ENTREZ:5599, UNIPROT:P45983 JNK2, mitogen-activated protein kinase 9 HUGO:MAPK9, HGNC:6886, ENTREZ:5601, UNIPROT:P45984 JNK3, mitogen-activated protein kinase 10 HUGO:MAPK10, HGNC:6872, ENTREZ:5602, UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21438496, PMID:21372320, PMID:19591900, PMID:17496919, PMID:15611655, PMID:8608010, PMID:20512932, PMID:20220133, PMID:20054826, PMID:19616017 References_end</body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="4110.2695" y="2311.0"/> <glyph class="state variable" id="_d80c78a2-c3c2-48aa-891b-a7bd3d315ab0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4159.338" y="2306.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s996_sa166" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <bbox w="80.0" h="40.0" x="5945.0205" y="6674.909"/> <glyph class="state variable" id="_48c5686d-a507-491f-a61f-550328ed6781"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5958.452" y="6669.909"/> </glyph> </glyph> <glyph class="macromolecule" id="s98_sa9" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ligase I, DNA, ATP-dependent HUGO:LIG1, HGNC:6598, ENTREZ:3978, UNIPROT:P18858 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:NER MODULE:MMR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 ,PMID:24050180 References_end</body> </html> </notes> <label text="LIG1"/> <bbox w="80.0" h="40.0" x="4885.269" y="7787.0"/> </glyph> <glyph class="macromolecule" id="s192_sa29" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ligase III DNA, ATP-dependent HUGO:LIG3, HGNC:6600, ENTREZ:3980, UNIPROT:P49916 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: For BER: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 For NER: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 Activation of WRN in cancers PMID:18524993 References_end</body> </html> </notes> <label text="LIG3"/> <bbox w="80.0" h="40.0" x="2255.769" y="8001.5"/> </glyph> <glyph class="macromolecule" id="s3385_sa126" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ligase IV, DNA, ATP-dependent HUGO:LIG4, HGNC:6601, ENTREZ:3981, UNIPROT:P49917 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:12471202, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="LIG4"/> <bbox w="80.0" h="40.0" x="6115.3066" y="7750.408"/> </glyph> <glyph class="macromolecule" id="s2454_sa1042" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD1 mitotic arrest deficient-like 1 (yeast) HUGO:MAD1L1, HGNC:6762, ENTREZ:8379, UNIPROT:Q9Y6D9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with CPC complex PMID:11402067, PMID:12640463 References_end</body> </html> </notes> <label text="MAD1*"/> <bbox w="80.0" h="40.0" x="4071.769" y="4632.4995"/> <glyph class="state variable" id="_3237d99f-ff4b-4867-8bc2-62b30051d114"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4074.6555" y="4627.4995"/> </glyph> </glyph> <glyph class="macromolecule" id="s2396_sa1098" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD1 mitotic arrest deficient-like 1 (yeast) HUGO:MAD1L1, HGNC:6762, ENTREZ:8379, UNIPROT:Q9Y6D9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with CPC complex PMID:11402067, PMID:12640463 References_end</body> </html> </notes> <label text="MAD1*"/> <bbox w="80.0" h="40.0" x="3955.33" y="4632.638"/> <glyph class="state variable" id="_d19d3605-0dad-48a6-b90b-643959f6246c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3960.7166" y="4627.638"/> </glyph> </glyph> <glyph class="macromolecule" id="s2278_sa924" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD2 mitotic arrest deficient-like 1 (yeast) HUGO:MAD2L1, HGNC:6763, ENTREZ:4085, UNIPROT:13257 MAD2 mitotic arrest deficient-like 2 (yeast) HUGO:MAD2L2, HGNC:6764, ENTREZ:10459, UNIPROT:Q9UI95 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:8824189, PMID:17498870, PMID:15024386, PMID:18022367 References_end</body> </html> </notes> <label text="MAD2*"/> <bbox w="80.0" h="40.0" x="4065.769" y="4583.5"/> </glyph> <glyph class="macromolecule" id="s2494_sa1116" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MYC associated factor X HUGO:MAX, HGNC:6913, ENTREZ:4149, UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:2006410, PMID:15121849, PMID:8425218, PMID:16908182 References_end</body> </html> </notes> <label text="MAX"/> <bbox w="80.0" h="40.0" x="4360.7695" y="2162.5"/> </glyph> <glyph class="macromolecule" id="s769_sa117" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: methyl-CpG binding domain protein 4 HUGO:MBD4, HGNC:6919, ENTREZ:8930, UNIPROT:O95243 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:MMR Maps_Modules_end References_begin: PMID:10545939, PMID:12417741, PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="MBD4"/> <bbox w="80.0" h="40.0" x="3330.3452" y="6584.0"/> </glyph> <glyph class="macromolecule" id="s2207_sa864" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 2 HUGO:MCM2, HGNC:6944, ENTREZ:4171, UNIPROT:P49736 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM2"/> <bbox w="80.0" h="40.0" x="5154.2695" y="727.49994"/> </glyph> <glyph class="macromolecule" id="s2208_sa865" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 3 HUGO:MCM3, HGNC:6945, ENTREZ:4172, UNIPROT:P25205 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM3"/> <bbox w="80.0" h="40.0" x="5154.2695" y="770.5"/> </glyph> <glyph class="macromolecule" id="s2209_sa866" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 4 HUGO:MCM4, HGNC:6947, ENTREZ:4173, UNIPROT:P33991 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM4"/> <bbox w="80.0" h="40.0" x="5154.2695" y="813.5"/> </glyph> <glyph class="macromolecule" id="s2210_sa867" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 5 HUGO:MCM5, HGNC:6948, ENTREZ:4174, UNIPROT:P33992 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM5"/> <bbox w="80.0" h="40.0" x="5154.2695" y="857.5"/> </glyph> <glyph class="macromolecule" id="s2211_sa868" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 6 HUGO:MCM6, HGNC:6949, ENTREZ:4175, UNIPROT:Q14566 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM6"/> <bbox w="80.0" h="40.0" x="5154.2695" y="901.50006"/> </glyph> <glyph class="macromolecule" id="s2212_sa869" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 7 HUGO:MCM7, HGNC:6950, ENTREZ:4176, UNIPROT:P33993 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM7"/> <bbox w="80.0" h="40.0" x="5154.2695" y="943.50006"/> </glyph> <glyph class="macromolecule" id="s1929_sa349" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1, HGNC:21163, ENTREZ:9656, UNIPROT:Q2TAZ4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:C_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890 References_end</body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="7451.3027" y="6284.8735"/> <glyph class="state variable" id="_8291cf2e-e2b4-4d6b-b274-bafdec402946"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7446.3027" y="6299.842"/> </glyph> </glyph> <glyph class="macromolecule" id="s1087_sa136" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1, HGNC:21163, ENTREZ:9656, UNIPROT:Q2TAZ4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:C_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890 References_end</body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="7304.7686" y="6284.4077"/> <glyph class="state variable" id="_b4c8bdbb-e07d-4a88-b88b-bc9ca790ce8d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7297.2686" y="6299.376"/> </glyph> </glyph> <glyph class="macromolecule" id="s687_sa83" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mdm2 p53 binding protein homolog (mouse) HUGO:MDM2, HGNC:6973, ENTREZ:4193, UNIPROT:Q13301 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:14761977, PMID:11779693, PMID:17110379, PMID:9450543, PMID:15876864 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="3130.0032" y="2311.668"/> <glyph class="state variable" id="_c5c7d616-d92c-4081-8f17-853a27889900"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3122.5032" y="2326.668"/> </glyph> </glyph> <glyph class="macromolecule" id="s685_sa81" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mdm2 p53 binding protein homolog (mouse) HUGO:MDM2, HGNC:6973, ENTREZ:4193, UNIPROT:Q13301 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:14761977, PMID:11779693, PMID:17110379, PMID:9450543, PMID:15876864 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="3128.0112" y="2171.0"/> <glyph class="state variable" id="_8269a789-84c6-44ed-ab92-23424470315c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3123.0112" y="2186.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3203_sa1481" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: O-6-methylguanine-DNA methyltransferase HUGO:MGMT, HGNC:7059, ENTREZ:4255, UNIPROT:P16455 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:DR Maps_Modules_end References_begin: PMID:18285820, PMID:17482892, PMID:8202360, PMID:17112791, PMID:19153659 References_end</body> </html> </notes> <label text="MGMT"/> <bbox w="80.0" h="40.0" x="10105.769" y="6451.5"/> </glyph> <glyph class="macromolecule" id="s2498_sa1119" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: zinc finger and BTB domain containing 17, MIZ1 HUGO:ZBTB17, HGNC:12936, ENTREZ:7709, UNIPROT:Q13105 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:9312026, PMID:15095404, PMID:19901969, PMID:19815509 References_end</body> </html> </notes> <label text="MIZ1*"/> <bbox w="80.0" h="40.0" x="4747.269" y="2347.5"/> </glyph> <glyph class="macromolecule" id="s1668_sa300" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="4522.1265" y="6943.2856"/> </glyph> <glyph class="macromolecule" id="s1669_sa301" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 3 (E. coli) HUGO:MLH3, HGNC:7128, ENTREZ:27030, UNIPROT:Q9UHC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH3"/> <bbox w="80.0" h="40.0" x="4515.005" y="6856.9854"/> </glyph> <glyph class="macromolecule" id="s1905_sa344" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) HUGO:MNAT1 , HGNC:7181, ENTREZ:4331, UNIPROT:P51948 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G,PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="MNAT1"/> <bbox w="80.0" h="40.0" x="4788.7017" y="459.964"/> </glyph> <glyph class="macromolecule" id="s3000_sa1376" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: N-methylpurine-DNA glycosylase HUGO:MPG, HGNC:7211, ENTREZ:4350, UNIPROT:P29372 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:14679184, PMID:9684856 References_end</body> </html> </notes> <label text="MPG"/> <bbox w="80.0" h="40.0" x="3179.269" y="6543.5"/> </glyph> <glyph class="macromolecule" id="s2409_sa1041" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TTK protein kinase, Cancer/testis antigen 96, MPS1 HUGO:TTK, HGNC:12401, ENTREZ:7272, UNIPROT:P33981 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: MPS1 phosphorylates Borealin and regulates AuroraB PMID:18243099 References_end</body> </html> </notes> <label text="MPS1*"/> <bbox w="80.0" h="40.0" x="3607.769" y="4873.5"/> <glyph class="state variable" id="_e9f9ea18-e2e3-417d-959c-1863862c98da"> <state value="P" variable="T676"/> <bbox w="35.0" h="10.0" x="3604.108" y="4868.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2394_sa1051" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TTK protein kinase, Cancer/testis antigen 96, MPS1 HUGO:TTK, HGNC:12401, ENTREZ:7272, UNIPROT:P33981 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: MPS1 phosphorylates Borealin and regulates AuroraB PMID:18243099 References_end</body> </html> </notes> <label text="MPS1*"/> <bbox w="80.0" h="40.0" x="3754.0796" y="4873.072"/> <glyph class="state variable" id="_66ab66d8-6ced-455a-8cf2-65b98c77f195"> <state value="" variable="T676"/> <bbox w="30.0" h="10.0" x="3752.9185" y="4868.072"/> </glyph> </glyph> <glyph class="macromolecule" id="s1518_sa133" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A, HGNC:7230, ENTREZ:4361, UNIPROT:P49959 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) HUGO:RE11B, HGNC:7231, ENTREZ:4362 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="7504.6875" y="5608.4077"/> </glyph> <glyph class="macromolecule" id="s3399_sa390" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="2251.5735" y="6840.753"/> <glyph class="state variable" id="_66cb6df3-39c2-4361-9cbe-962e90d13e54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2246.5735" y="6855.753"/> </glyph> </glyph> <glyph class="macromolecule" id="s634_sa69" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="2410.1326" y="6828.1274"/> <glyph class="state variable" id="_c9906aaf-1143-43d6-9eef-c7225e05b5f2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2402.6326" y="6843.1274"/> </glyph> </glyph> <glyph class="macromolecule" id="s1671_sa303" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 3 (E. coli) HUGO:MSH3, HGNC:7326, ENTREZ:4437, UNIPROT:P20585 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:SSA Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH3"/> <bbox w="80.0" h="40.0" x="4527.186" y="6721.75"/> </glyph> <glyph class="macromolecule" id="s635_sa70" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 6 (E. coli) HUGO:MSH6, HGNC:7329, ENTREZ:2956, UNIPROT:P52701 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MSH6"/> <bbox w="80.0" h="40.0" x="2407.1326" y="6906.456"/> <glyph class="state variable" id="_b8384e21-41f3-4ee6-9b1a-38ed43a254cb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2399.6326" y="6921.456"/> </glyph> </glyph> <glyph class="macromolecule" id="s630_sa68" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 6 (E. coli) HUGO:MSH6, HGNC:7329, ENTREZ:2956, UNIPROT:P52701 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MSH6"/> <bbox w="80.0" h="40.0" x="2257.7344" y="6897.1475"/> <glyph class="state variable" id="_05682190-90d3-439f-9355-658a061399f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2252.7344" y="6912.1475"/> </glyph> </glyph> <glyph class="macromolecule" id="s1063_sa187" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MUS81 endonuclease homolog (S. cerevisiae) HUGO:MUS81, HGNC:29814, ENTREZ:80198, UNIPROT:Q96NY9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258, PMID:22101340 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MUS81"/> <bbox w="80.0" h="40.0" x="7427.6064" y="8275.999"/> </glyph> <glyph class="macromolecule" id="s763_sa115" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutY homolog (E. coli) HUGO:MUTYH, HGNC:7527, ENTREZ:4595, UNIPROT:Q9UIF7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:23507534 References_end</body> </html> </notes> <label text="MUTH*"/> <bbox w="80.0" h="40.0" x="2261.3115" y="6964.067"/> </glyph> <glyph class="macromolecule" id="s2506_sa1128" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC, HGNC:7553, ENTREZ:4609, UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4365.162" y="2324.024"/> <glyph class="state variable" id="_1d94bf17-6308-4cfe-978a-b6eba3312a74"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="4355.162" y="2339.024"/> </glyph> </glyph> <glyph class="macromolecule" id="s2493_sa1115" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC, HGNC:7553, ENTREZ:4609, UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4365.2695" y="2243.262"/> <glyph class="state variable" id="_4b45fdec-7d48-456a-8c88-11feba27b097"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4360.2695" y="2258.262"/> </glyph> </glyph> <glyph class="macromolecule" id="s2480_sa1106" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: multiple endocrine neoplasia I HUGO:MEN1, HGNC:7010, ENTREZ:4221, UNIPROT:O00255 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:12874027, PMID:19407509, PMID:11302744 References_end</body> </html> </notes> <label text="Menin*"/> <bbox w="80.0" h="40.0" x="3988.769" y="1453.5"/> </glyph> <glyph class="macromolecule" id="s1526_sa256" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="7653.7686" y="5528.5"/> <glyph class="state variable" id="_65becd9d-e839-457e-91c8-5e80beeff6bf"> <state value="" variable="S343"/> <bbox w="30.0" h="10.0" x="7638.7686" y="5551.684"/> </glyph> </glyph> <glyph class="macromolecule" id="s1525_sa135" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="7509.1875" y="5530.4077"/> <glyph class="state variable" id="_520f669b-1243-4d65-89b6-d0207e06053d"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="7491.6875" y="5553.592"/> </glyph> </glyph> <glyph class="macromolecule" id="s3028_sa1393" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: neural precursor cell expressed, developmentally sown regulated 4 HUGO:NEDD4, HGNC:7727, ENTREZ:4734, UNIPROT:P46934 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17996703 References_end</body> </html> </notes> <label text="NEDD4"/> <bbox w="80.0" h="40.0" x="102.76929" y="6692.5"/> </glyph> <glyph class="macromolecule" id="s3038_sa1397" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: neural precursor cell expressed, developmentally down-regulated 8 HUGO:NEDD8, HGNC:7732, ENTREZ:4738, UNIPROT:Q15843 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:9694792, PMID:18805092, PMID:19250909 References_end</body> </html> </notes> <label text="NEDD8"/> <bbox w="80.0" h="40.0" x="381.38037" y="6407.0674"/> </glyph> <glyph class="macromolecule" id="s2995_sa1372" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nei like 1 (E. coli) HUGO:NEIL1, HGNC:18448, ENTREZ:79661, UNIPROT:Q96FI4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="NEIL1"/> <bbox w="80.0" h="40.0" x="2257.8115" y="6646.567"/> </glyph> <glyph class="macromolecule" id="s2996_sa1373" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nei like 2 (E. coli) HUGO:NEIL2, HGNC:18956, ENTREZ:252969, UNIPROT:Q969S2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="NEIL2"/> <bbox w="80.0" h="40.0" x="2071.269" y="6521.5"/> </glyph> <glyph class="macromolecule" id="s2997_sa1374" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nei like 3 (E. coli) HUGO:NEIL3, HGNC:24573, ENTREZ:55247, UNIPROT:Q8TAT5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="NEIL3"/> <bbox w="80.0" h="40.0" x="2077.269" y="6475.5"/> </glyph> <glyph class="macromolecule" id="s897_sa118" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nth endonuclease III-like 1 (E. coli) HUGO:NTHL1, HGNC:8028, ENTREZ:4913, UNIPROT:P78549 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="NTH1*"/> <bbox w="80.0" h="40.0" x="2257.855" y="6552.106"/> </glyph> <glyph class="macromolecule" id="s754_sa114" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 8-oxoguanine DNA glycosylase HUGO:OGG1, HGNC:8125, ENTREZ:4968, UNIPROT:Q9Y6C4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:11307145, PMID:11948476, PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="OGG1"/> <bbox w="80.0" h="40.0" x="2251.3115" y="6783.067"/> </glyph> <glyph class="macromolecule" id="s2192_sa848" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 1-like (yeast) HUGO:ORC1L, HGNC:8487, ENTREZ:4998, UNIPROT:Q13415 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC1*"/> <bbox w="80.0" h="40.0" x="5154.2695" y="432.50003"/> </glyph> <glyph class="macromolecule" id="s2193_sa849" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 2-like (yeast) HUGO:ORC2L, HGNC:8488, ENTREZ:4999, UNIPROT:Q13416 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC2*"/> <bbox w="80.0" h="40.0" x="5154.2695" y="476.49997"/> </glyph> <glyph class="macromolecule" id="s2194_sa850" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 3-like (yeast) HUGO:ORC3L, HGNC:8489, ENTREZ:23595, UNIPROT:Q9UNT6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC3*"/> <bbox w="80.0" h="40.0" x="5154.2695" y="517.49994"/> </glyph> <glyph class="macromolecule" id="s2195_sa853" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 4-like (yeast) HUGO:ORC4L, HGNC:8490, ENTREZ:5000, UNIPROT:O43929 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC4*"/> <bbox w="80.0" h="40.0" x="5154.2695" y="560.49994"/> </glyph> <glyph class="macromolecule" id="s2196_sa854" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 5-like (yeast) HUGO:ORC5L, HGNC:8491, ENTREZ:5001, UNIPROT:O43913 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC5*"/> <bbox w="80.0" h="40.0" x="5154.2695" y="604.49994"/> </glyph> <glyph class="macromolecule" id="s2197_sa855" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 6-like (yeast) HUGO:ORC6L, HGNC:17151, ENTREZ:23594, UNIPROT:Q9Y5N6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC6*"/> <bbox w="80.0" h="40.0" x="5154.2695" y="646.49994"/> </glyph> <glyph class="macromolecule" id="s3370_sa1583" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) glycohydrolase HUGO:PARG, HGNC:8605, ENTREZ:8505, UNIPRIT:Q86W56 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22713970, PMID:22469522, PMID:196269035 References_end</body> </html> </notes> <label text="PARG"/> <bbox w="80.0" h="40.0" x="2351.769" y="7760.5"/> </glyph> <glyph class="macromolecule" id="s3373_sa1586" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="79.0" h="40.0" x="2586.064" y="7693.269"/> <glyph class="state variable" id="_1a3e40c7-0f0a-4aaa-b611-8d2146d65d29"> <state value="" variable="PolyADPribose"/> <bbox w="75.0" h="10.0" x="2583.7332" y="7688.269"/> </glyph> <glyph class="state variable" id="_2e2d3441-4c52-4a4b-9da7-3622cf773c8e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2660.064" y="7708.269"/> </glyph> <glyph class="state variable" id="_037695a3-d5a2-484e-ac22-d5993c2fc593"> <state value="P" variable="Ser786"/> <bbox w="45.0" h="10.0" x="2572.2563" y="7728.269"/> </glyph> <glyph class="state variable" id="_e52e4984-c700-401a-8e2e-48bd742fcdcd"> <state value="P" variable="Ser782"/> <bbox w="45.0" h="10.0" x="2563.564" y="7712.4985"/> </glyph> <glyph class="state variable" id="_40502b48-763b-4f1b-a03b-1bf548bca9f4"> <state value="P" variable="Ser785"/> <bbox w="45.0" h="10.0" x="2563.564" y="7722.2"/> </glyph> </glyph> <glyph class="macromolecule" id="s2567_sa1166" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="75.0" h="43.0" x="2448.425" y="7680.068"/> <glyph class="state variable" id="_c92b8392-0587-4e36-b063-b6ad5acca8ac"> <state value="" variable="PolyADPribose"/> <bbox w="75.0" h="10.0" x="2444.3135" y="7675.068"/> </glyph> <glyph class="state variable" id="_eb3fb4ca-a567-4da6-b6f5-d72fa8095b30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2518.425" y="7696.568"/> </glyph> <glyph class="state variable" id="_7040c9c8-2bf9-4447-9a8e-94c1acdfe57e"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="2436.6772" y="7718.068"/> </glyph> <glyph class="state variable" id="_7e0afe68-296c-4c53-a3dc-d738fc5faae6"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="2428.425" y="7701.1147"/> </glyph> <glyph class="state variable" id="_5cc996ae-c246-4b43-91ab-f55e7ffb28df"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="2428.425" y="7711.544"/> </glyph> </glyph> <glyph class="macromolecule" id="s3266_sa1548" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 2 HUGO:PARP2, HGNC:272, ENTREZ:10038, Q9UGN5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARPs in cellular functions PMID:22713970 PARP1 and PARP2 in HR and in inhibition of C_NHEJ PMID:22469522, PMID:196269035 PARP2 in chromatin remodeling PMID:22469522, PMID:22713970 References_end</body> </html> </notes> <label text="PARP2"/> <bbox w="80.0" h="40.0" x="2258.769" y="7598.5"/> <glyph class="state variable" id="_9d378bb8-b263-4af9-9dfd-fafa01302ab3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2331.269" y="7612.78"/> </glyph> <glyph class="state variable" id="_cca39ef4-f73f-46fe-baa4-2aadbabe22c0"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="2288.6782" y="7593.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3260_sa1554" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 2 HUGO:PARP2, HGNC:272, ENTREZ:10038, Q9UGN5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARPs in cellular functions PMID:22713970 PARP1 and PARP2 in HR and in inhibition of C_NHEJ PMID:22469522, PMID:196269035 PARP2 in chromatin remodeling PMID:22469522, PMID:22713970 References_end</body> </html> </notes> <label text="PARP2"/> <bbox w="80.0" h="40.0" x="2419.7273" y="7599.9585"/> <glyph class="state variable" id="_592fcdf6-39ee-4ff7-bddf-ad789f408722"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2494.7273" y="7614.2383"/> </glyph> <glyph class="state variable" id="_c222400c-71b3-4415-88f9-6bf168afac77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2452.1365" y="7594.9585"/> </glyph> </glyph> <glyph class="macromolecule" id="s2485_sa1110" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: K(lysine) acetyltransferase 2A HUGO:KAT2A, HGNC:4201, ENTREZ:2648, UNIPROT:Q92830 K(lysine) acetyltransferase 2B HUGO:KAT2B, HGNC:8638, ENTREZ:8850, UNIPROT:Q92831 KAT3B, E1A binding protein p300 HUGO:EP300, HGNC:3373, ENTREZ:2033, UNIPROT:Q09472 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:11804596, PMID:19407812, PMID:12660246 References_end</body> </html> </notes> <label text="PCAF*"/> <bbox w="80.0" h="40.0" x="5123.7695" y="4752.5"/> </glyph> <glyph class="macromolecule" id="s3056_sa12" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="7827.637" y="7296.422"/> <glyph class="state variable" id="_ef0464c9-e6b7-4d87-811b-13246c298f50"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="7816.621" y="7291.422"/> </glyph> <glyph class="state variable" id="_9d3de99f-e249-4ce2-89f3-231dc1d2213a"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="7812.637" y="7311.422"/> </glyph> <glyph class="state variable" id="_4b369821-e86f-4629-a0f4-ad6b31bcd9a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7846.069" y="7331.422"/> </glyph> <glyph class="state variable" id="_a6fd901f-faa9-4eef-b326-d944247bcdcf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7822.637" y="7331.422"/> </glyph> <glyph class="state variable" id="_d3bc34cb-3b12-4b8a-997d-480f679939d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7862.637" y="7331.422"/> </glyph> </glyph> <glyph class="macromolecule" id="s1264_sa238" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="9979.931" y="6981.4014"/> <glyph class="state variable" id="_b020bf58-7e59-4347-96c4-64c0b25e9799"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9968.914" y="6976.4014"/> </glyph> <glyph class="state variable" id="_4688c941-d298-4a4f-902e-efc0a5d7be3d"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9959.931" y="6996.4014"/> </glyph> <glyph class="state variable" id="_5ade8a5f-14a3-4bf6-950d-f341683059c8"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9993.362" y="7016.4014"/> </glyph> <glyph class="state variable" id="_5355c486-f090-48b2-b297-4ebe7432d158"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9969.931" y="7016.4014"/> </glyph> <glyph class="state variable" id="_24eb3eab-fb91-4761-a298-ca9eb609fa42"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10009.931" y="7016.4014"/> </glyph> </glyph> <glyph class="macromolecule" id="s1256_sa234" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="7348.0586" y="5344.685"/> <glyph class="state variable" id="_718b8518-ce7d-45e0-9213-c624fad4d41d"> <state value="*" variable="K127"/> <bbox w="35.0" h="10.0" x="7334.5425" y="5339.685"/> </glyph> <glyph class="state variable" id="_50698c33-3c1f-4d92-8874-6fb6ece38c6e"> <state value="*" variable="K164"/> <bbox w="35.0" h="10.0" x="7330.5586" y="5359.685"/> </glyph> <glyph class="state variable" id="_44a6adbd-5b59-4b59-a26a-35968d0fab33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7366.49" y="5379.685"/> </glyph> <glyph class="state variable" id="_6dd4babf-5145-4e53-ad39-5c981a08981d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7343.0586" y="5379.685"/> </glyph> <glyph class="state variable" id="_a3d8c655-07b3-411b-ba81-94ff5a7085d5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7383.0586" y="5379.685"/> </glyph> </glyph> <glyph class="macromolecule" id="s646_sa73" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase C, alpha HUGO:PRKCA, HGNC:9393, ENTREZ:5578, UNIPROT:P17252 protein kinase C, beta HUGO:PRKCB, HGNC:9395, ENTREZ:5579, UNIPROT:P05771 protein kinase C, gamma HUGO:PRKCG, HGNC:9402, ENTREZ:5582, UNIPROT:P05129 protein kinase C, delta HUGO:PRKCD, HGNC:9399, ENTREZ:5580, UNIPROT:Q05655 protein kinase C, epsilon HUGO:PRKCE, HGNC:9401, ENTREZ:5581, UNIPROT:Q02156 protein kinase C, zeta HUGO:PRKCZ, HGNC:9412, ENTREZ:5590, UNIPROT:Q05513 protein kinase C, eta HUGO:PRKCH, HGNC:9403, ENTREZ:5583, UNIPROT:P24723 protein kinase C, theta HUGO:PRKCQ, HGNC:9410, ENTREZ:5588, UNIPROT:Q04759 protein kinase C, iota HUGO:PRKCI, HGNC:9404, ENTREZ:5584, UNIPROT:P41743 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:20647370, PMID:21720730, PMID:21715253, PMID:21720730, PMID:21441608 References_end</body> </html> </notes> <label text="PKC*"/> <bbox w="80.0" h="40.0" x="5728.8574" y="2335.3423"/> <glyph class="state variable" id="_664dbc71-4341-4685-95c5-cb614eb1b3cb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5721.3574" y="2350.3423"/> </glyph> </glyph> <glyph class="macromolecule" id="s644_sa71" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase C, alpha HUGO:PRKCA, HGNC:9393, ENTREZ:5578, UNIPROT:P17252 protein kinase C, beta HUGO:PRKCB, HGNC:9395, ENTREZ:5579, UNIPROT:P05771 protein kinase C, gamma HUGO:PRKCG, HGNC:9402, ENTREZ:5582, UNIPROT:P05129 protein kinase C, delta HUGO:PRKCD, HGNC:9399, ENTREZ:5580, UNIPROT:Q05655 protein kinase C, epsilon HUGO:PRKCE, HGNC:9401, ENTREZ:5581, UNIPROT:Q02156 protein kinase C, zeta HUGO:PRKCZ, HGNC:9412, ENTREZ:5590, UNIPROT:Q05513 protein kinase C, eta HUGO:PRKCH, HGNC:9403, ENTREZ:5583, UNIPROT:P24723 protein kinase C, theta HUGO:PRKCQ, HGNC:9410, ENTREZ:5588, UNIPROT:Q04759 protein kinase C, iota HUGO:PRKCI, HGNC:9404, ENTREZ:5584, UNIPROT:P41743 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:20647370, PMID:21720730, PMID:21715253, PMID:21720730, PMID:21441608 References_end</body> </html> </notes> <label text="PKC*"/> <bbox w="80.0" h="40.0" x="5723.269" y="2151.0"/> <glyph class="state variable" id="_71e27cdf-e4d3-454f-9a73-912fe6b65855"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5718.269" y="2166.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2246_sa911" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, membrane associated tyrosine/threonine 1 HUGO:PKMYT1, HGNC:29650, ENTREZ:9088, UNIPROT:Q99640 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:10504341, PMID:10373560, PMID:12738781 References_end</body> </html> </notes> <label text="PKMYT1"/> <bbox w="80.0" h="40.0" x="4721.166" y="2222.4302"/> <glyph class="state variable" id="_b5bbb64b-379c-43f1-a615-acc6ed0dc5b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4716.166" y="2237.4302"/> </glyph> </glyph> <glyph class="macromolecule" id="s2263_sa215" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polo-like kinase 1 (Drosophila) HUGO:PLK1, HGNC:9077, ENTREZ:5347, UNIPROT:P53350 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis. PMID:19270156 References_end</body> </html> </notes> <label text="PLK1"/> <bbox w="80.0" h="40.0" x="5022.2695" y="2166.0"/> <glyph class="state variable" id="_5d6b6efe-6fea-4a94-b312-96f101431b77"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5014.7695" y="2181.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1128_sa914" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polo-like kinase 1 (Drosophila) HUGO:PLK1, HGNC:9077, ENTREZ:5347, UNIPROT:P53350 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis. PMID:19270156 References_end</body> </html> </notes> <label text="PLK1"/> <bbox w="80.0" h="40.0" x="5023.4727" y="2323.1006"/> <glyph class="state variable" id="_c4585347-4b12-411e-af25-1eecc839e055"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5018.4727" y="2338.1006"/> </glyph> </glyph> <glyph class="macromolecule" id="s1670_sa302" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PMS1 postmeiotic segregation increased 1 (S. cerevisiae) HUGO:PMS1, HGNC:9121, ENTREZ:5378, UNIPROT:P54277 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="PMS1"/> <bbox w="80.0" h="40.0" x="4515.005" y="7030.9854"/> </glyph> <glyph class="macromolecule" id="s1672_sa304" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PMS1 postmeiotic segregation increased 2 (S. cerevisiae) HUGO:PMS2, HGNC:9122, ENTREZ:5395, UNIPROT:P54278 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="PMS2"/> <bbox w="80.0" h="40.0" x="4172.1865" y="6729.75"/> </glyph> <glyph class="macromolecule" id="s3191_sa1472" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Polynucleotide kinase 3'-phosphatase HUGO:PNKP, HGNC:9154, ENTREZ:11284, UNIPROT:Q96T60 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ MODULE:BER Maps_Modules_end References_begin: PMID:20691907 For C_NHEJ PMID:17638872, PMID:15385968, PMID:12032095 For BER PMID:11163244, PMID:19546231 References_end</body> </html> </notes> <label text="PNK*"/> <bbox w="80.0" h="40.0" x="5831.3145" y="7032.409"/> </glyph> <glyph class="macromolecule" id="s2266_sa918" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), alpha 1, catalytic subunit HUGO:POLA1, HGNC:9173, ENTREZ:5422, UNIPROT:P09884 polymerase (DNA directed), alpha 2 (70kD subunit) HUGO:POLA2, HGNC:30073, ENTREZ:23649, UNIPROT:Q14181 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="POLA*"/> <bbox w="80.0" h="40.0" x="5614.6074" y="783.27234"/> </glyph> <glyph class="macromolecule" id="s3057_sa27" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PolB, polymerase (DNA directed), beta HUGO:POLB, HGNC:9174, ENTREZ:5423, UNIPROT:P06746 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs PMID:20510258, PMID:21251944 References_end</body> </html> </notes> <label text="POLB"/> <bbox w="80.0" h="40.0" x="2067.269" y="7134.5"/> </glyph> <glyph class="macromolecule" id="s108_sa171" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), delta 1, catalytic subunit 125kDa HUGO:POLD1, HGNC:9175, ENTREZ:5424, UNIPROT:P28340 polymerase (DNA directed), delta 2, regulatory subunit 50kDa HUGO:POLD2, HGNC:9176, ENTREZ:5425, UNIPROT:P49005 polymerase (DNA-directed), delta 3, accessory subunit HUGO:POLD3, HGNC:20932, ENTREZ:10714, UNIPROT:Q15054 polymerase (DNA-directed), delta 4 HUGO:POLD4, HGNC:14106, ENTREZ:57804, UNIPROT:Q9HCU8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20478261 For A_NHEJ PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 References_end</body> </html> </notes> <label text="POLD*"/> <bbox w="80.0" h="40.0" x="7200.875" y="7830.4"/> </glyph> <glyph class="macromolecule" id="s109_sa13" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), epsilon HUGO:POLE, HGNC:9177, ENTREZ:5426, UNIPROT:Q07864 polymerase (DNA directed), epsilon 2 (p59 subunit) HUGO:POLE2, HGNC:9178, ENTREZ:5427, UNIPROT:P56282 polymerase (DNA directed), epsilon 3 (p17 subunit) HUGO:POLE3, HGNC:13546, ENTREZ:54107, UNIPROT:Q9NRF9 polymerase (DNA-directed), epsilon 4 (p12 subunit) HUGO:POLE4, HGNC:18755, ENTREZ:56655, UNIPROT:Q9NR33 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="POLE*"/> <bbox w="80.0" h="40.0" x="1310.0859" y="7743.882"/> </glyph> <glyph class="macromolecule" id="s1244_sa232" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), eta HUGO:POLH, HGNC:9181, ENTREZ:5429, UNIPROT:Q9Y253 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to the Y-family polymerases PMID:19258535 POLH participates in the D-loop formation in HR PMID:16337602, PMID:16337601 Bypasses thymidine-thymidine (T-T) cyclobutane pyrimidine dimer (CPD) very accurately PMID:15189446 Cisplatin tolerance in cells with active POLH PMID:22562137 References_end</body> </html> </notes> <label text="POLH"/> <bbox w="80.0" h="40.0" x="9798.305" y="6934.073"/> </glyph> <glyph class="macromolecule" id="s1251_sa233" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) iota HUGO:POLI, HGNC:9182, ENTREZ:11201, UNIPROT:Q9UNA4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to the Y-family polymerases PMID:19258535 Bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta PMID:15189446, PMID:12466554 References_end</body> </html> </notes> <label text="POLI"/> <bbox w="80.0" h="40.0" x="7091.286" y="5189.073"/> </glyph> <glyph class="macromolecule" id="s1240_sa231" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) kappa HUGO:POLK, HGNC:9183, ENTREZ:51426, UNIPROT:Q96Q87 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:NER Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to Y-family polymerases PMID:19258535 Bypasses benzo(a)pyrene (B(a)P) adducts on guanine (dG-n2-BPDE adducts) PMID:15189466 For NER pathway PMID:20227374 References_end</body> </html> </notes> <label text="POLK"/> <bbox w="80.0" h="40.0" x="9798.769" y="6800.5"/> </glyph> <glyph class="macromolecule" id="s990_sa272" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), lambda HUGO:POLL, HGNC:9184, ENTREZ:27343, UNIPROT:Q9UGP5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ MODULE:FANCONI MODULE:C_NHEJ Maps_Modules_end References_begin: For A_NHEJ PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 For Fanconi anemia PATHWAY PMID:19686080, PMID:19622404, PMID:18931676 For PoLL in C_NHEJ PMID:16738138, PMID:19806195, PMID:18585102 References_end</body> </html> </notes> <label text="POLL"/> <bbox w="80.0" h="40.0" x="3528.731" y="6423.0"/> </glyph> <glyph class="macromolecule" id="s3048_sa1406" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), mu HUGO:POLM, HGNC:9185, ENTREZ:27434, UNIPROT:Q9NP87 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17483519, PMID:17631059, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="POLM"/> <bbox w="80.0" h="40.0" x="5706.731" y="7598.5"/> </glyph> <glyph class="macromolecule" id="s991_sa164" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) nu HUGO:POLN, HGNC:18870, ENTREZ:353497, UNIPROT:Q7Z5Q5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR PMID:19772495, PMID:16697054, PMID:19847258 For A_NHEJ PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 Complex PolN:HEL308 participates in HR and in Fanconi pathways PMID:19995904 References_end</body> </html> </notes> <label text="POLN"/> <bbox w="80.0" h="40.0" x="7196.1064" y="7699.0"/> </glyph> <glyph class="macromolecule" id="s1433_sa263" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), theta HUGO:POLQ, HGNC:9186, ENTREZ:10721, UNIPROT:O75417 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:FANCONI Maps_Modules_end References_begin: PMID:10395804, PMID:14576298, PMID:18503084, PMID:15496986 PMID:20624954, PMID:18472307 References_end</body> </html> </notes> <label text="POLQ"/> <bbox w="80.0" h="40.0" x="2059.269" y="7452.25"/> </glyph> <glyph class="macromolecule" id="s1124_sa212" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV3-like, catalytic subunit of DNA polymerase zeta (yeast) HUGO:REV3L, HGNC:9968, ENTREZ:5980, UNIPROT:O60673 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: Related to the B-family polymerases. The first subunit of the Pol zeta complex (the second subunit is REV7) PMID:19686080, PMID:19622404, PMID:18931676 PMID:23065650 References_end</body> </html> </notes> <label text="POLZ*"/> <bbox w="80.0" h="40.0" x="9559.268" y="6442.0"/> </glyph> <glyph class="macromolecule" id="s1478_sa137" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2A activator, regulatory subunit 4 HUGO:PPP2R4, HGNC:9308, ENTREZ:5524, UNIPROT:Q9NNZ7 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform HUGO:PPP2CA, HGNC:9299, ENTREZ:5515, UNIPROT:P67775 protein phosphatase 2, regulatory subunit B', gamma isoform HUGO:PPP2R5C , HGNC:9311, ENTREZ:5527, UNIPROT:Q13362 protein phosphatase 2, regulatory subunit B', delta isoform HUGO:PPP2R5D , HGNC:9312, ENTREZ:5528, UNIPROT:Q14738 protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform HUGO:PPP2R2B, HGNC:9305, ENTREZ:5521, UNIPROT:Q00005 protein phosphatase 2, regulatory subunit B', alpha isoform HUGO:PPP2R5A , HGNC:9309, ENTREZ:5525, UNIPROT:Q15172 protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform HUGO:PPP2R2A , HGNC:9304, ENTREZ:5520, UNIPROT:P63151 protein phosphatase 2, regulatory subunit B', epsilon isoform HUGO:PPP2R5E , HGNC:9313, ENTREZ:5529, UNIPROT:Q16537 protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform HUGO:PPP2R1B , HGNC:9303, ENTREZ:5519, UNIPROT:P30154 protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform HUGO:PPP2R1A, HGNC:9302, ENTREZ:5518, UNIPROT:P30153 protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform HUGO:PPP2R2C, HGNC:9306, ENTREZ:5522, UNIPROT:Q9Y2T4 protein phosphatase 2, regulatory subunit B', beta isoform HUGO:PPP2R5B , HGNC:9310, ENTREZ:5526, UNIPROT:Q15173 protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha HUGO:PPP2R3A , HGNC:9307, ENTREZ:5523, UNIPROT:Q06190 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform HUGO:PPP2CB , HGNC:9300, ENTREZ:5516, UNIPROT:P62714 HUGO:PPP2R2D , HGNC:23732, ENTREZ:55844, UNIPROT:Q66LE6 protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta HUGO:PPP2R3B , HGNC:13417, ENTREZ:28227, UNIPROT:Q9Y5P8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:16885030, PMID:16916641, PMID:19890961, PMID:12370081, PMID:10921877, PMID:21376459, PMID:21159657 References_end</body> </html> </notes> <label text="PP2A*"/> <bbox w="80.0" h="40.0" x="6202.7686" y="2245.4077"/> </glyph> <glyph class="macromolecule" id="s2931_sa1317" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein phosphatase 5, catalytic subunit HUGO:PPP5C, HGNC:9322, ENTREZ:5536, UNIPROT:P53041 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:16260606, PMID:14871926 References_end</body> </html> </notes> <label text="PPP5C"/> <bbox w="80.0" h="40.0" x="5931.7686" y="3112.5002"/> </glyph> <glyph class="macromolecule" id="s2268_sa919" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: primase, DNA, polypeptide 1 (49kDa) HUGO:PRIM1, HGNC:9369, ENTREZ:5557, UNIPROT:P49642 primase, DNA, polypeptide 2 (58kDa) HUGO:PRIM2, HGNC:9370, ENTREZ:5558, UNIPROT:P49643 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="PRIM*"/> <bbox w="80.0" h="40.0" x="5704.769" y="784.5"/> </glyph> <glyph class="macromolecule" id="s2929_sa1315" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase C, delta HUGO:PRKCD, HGNC:9399, ENTREZ:5580, UNIPROT:Q05655 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="PRKCD"/> <bbox w="80.0" h="40.0" x="3436.3452" y="7042.5"/> </glyph> <glyph class="macromolecule" id="s2905_sa1297" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD1 homolog (S. pombe) HUGO:RAD1, HGNC:9806, ENTREZ:5810, UNIPROT:O60671 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="RAD1"/> <bbox w="80.0" h="40.0" x="3337.769" y="7146.5"/> </glyph> <glyph class="macromolecule" id="s1943_sa352" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD17 homolog (S. pombe) HUGO:RAD17, HGNC:9807, ENTREZ:5884, UNIPROT:O75943 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:16885023, PMID:17303408 References_end</body> </html> </notes> <label text="RAD17"/> <bbox w="80.0" h="40.0" x="5760.0186" y="3198.5002"/> <glyph class="state variable" id="_85577c9e-508f-40dd-84f3-204864e922e7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5752.5186" y="3213.5002"/> </glyph> </glyph> <glyph class="macromolecule" id="s1941_sa353" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD17 homolog (S. pombe) HUGO:RAD17, HGNC:9807, ENTREZ:5884, UNIPROT:O75943 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:16885023, PMID:17303408 References_end</body> </html> </notes> <label text="RAD17"/> <bbox w="80.0" h="40.0" x="5941.3936" y="3188.4062"/> <glyph class="state variable" id="_e134b732-3bc2-4e48-adfa-12b6c086164f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5936.3936" y="3203.4062"/> </glyph> </glyph> <glyph class="macromolecule" id="s1223_sa230" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD18 homolog (S. cerevisiae) HUGO:RAD18, HGNC:18278, ENTREZ:56852, UNIPROT:Q9NS91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: Rad 18 in complex with UBE2B (or UBE2A) ubiquitinates PCNA that maked PCNA available to TLS pathway specifically PMID:20129063 RAD18 is a E3 ligase PMID:10884424, PMID:18363965, PMID:19013543, PMID:16611994, PMID:19396164, PMID:19258535, PMID:20675655, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="RAD18"/> <bbox w="80.0" h="40.0" x="9889.269" y="6628.0"/> </glyph> <glyph class="macromolecule" id="s830_sa32" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD23 homolog A (S. cerevisiae) HUGO:RAD23A, HGNC:9812, ENTREZ:5886, UNIPROT:P54725 RAD23 homolog B HUGO:RAD23B, HGNC:9813, ENTREZ:5887, UNIPROT:P54727 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="RAD23*"/> <bbox w="80.0" h="40.0" x="3340.3452" y="6724.0"/> </glyph> <glyph class="macromolecule" id="s1259_sa237" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SNF2 histone linker PHD RING helicase, Rad5 HUGO:SHPRH, HGNC:19336, ENTREZ:257218, UNIPROT:Q8NBR7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:10880451, PMID:16224103, PMID:19851286, PMID:18647995 References_end</body> </html> </notes> <label text="RAD5*"/> <bbox w="80.0" h="40.0" x="9880.269" y="6934.0"/> </glyph> <glyph class="macromolecule" id="s53_sa134" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="7504.6875" y="5660.4077"/> </glyph> <glyph class="macromolecule" id="s1027_sa193" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51A HUGO:RAD51, HGNC:9817, ENTREZ:5888, UNIPROT:Q06609 RAD51-like 1 (S. cerevisiae), RAD51B HUGO:RAD51L1, HGNC:9822, ENTREZ:5890, UNIPROT:Q86U92 RAD51 homolog C (S. cerevisiae) HUGO:RAD51C, HGNC:9820, ENTREZ:5889, UNIPROT:O43502 RAD51-like 3 (S. cerevisiae), RAD51D HUGO:RAD51L3, HGNC:9823, ENTREZ:5892, UNIPROT:O94908 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="80.0" h="40.0" x="7823.3687" y="7246.0"/> </glyph> <glyph class="macromolecule" id="s1069_sa190" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD52 homolog (S. cerevisiae) HUGO:RAD52, HGNC:9824, ENTREZ:5893, UNIPROT:P43351 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For SSA pathway PMID:19473888, PMID:12947387 RAD52 in SSA pathway is acting as RAD51 in HR. RAD52 is a key factor initating SSA pathway PMID:11571269, PMID:20081207 References_end</body> </html> </notes> <label text="RAD52"/> <bbox w="80.0" h="40.0" x="7565.2686" y="6698.0"/> </glyph> <glyph class="macromolecule" id="s1055_sa184" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD54 homolog B (S. cerevisiae) HUGO:RAD54B, HGNC:17228, ENTREZ:25788, UNIPROT:Q9Y620 RAD54-like (S. cerevisiae) HUGO:RAD54L, HGNC:9826, ENTREZ:8438, UNIPROT:Q92698 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="RAD54*"/> <bbox w="80.0" h="40.0" x="7201.6064" y="7943.999"/> </glyph> <glyph class="macromolecule" id="s1269_sa242" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A (RAD6 homolog) HUGO:UBE2A, HGNC:12472, ENTREZ:7319, UNIPROT:P49459 ubiquitin-conjugating enzyme E2B (RAD6 homolog) HUGO:UBE2B, HGNC:12473, ENTREZ:7320, UNIPROT:P63146 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 In complex with RAD18 ubiquitinates PCNA at Lys164 making PCNA specific for TLS DNA repair activation PMID:19258535 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="9889.269" y="6574.0"/> </glyph> <glyph class="macromolecule" id="s2928_sa1298" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="3335.769" y="7094.5"/> <glyph class="state variable" id="_cf05c9de-4f6a-49be-896c-aedce42fe5b0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3368.269" y="7089.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s2906_sa1314" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="3522.3452" y="7093.8643"/> <glyph class="state variable" id="_c7b43e97-c845-4e80-981d-6ffe5ed34ad6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3557.3452" y="7088.8643"/> </glyph> </glyph> <glyph class="macromolecule" id="s75_sa323" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma 1 HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440 References_end</body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="4613.644" y="1037.3751"/> <glyph class="state variable" id="_5e6bc5a8-9a43-41c5-bef7-fe970fe1b283"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4686.144" y="1052.3751"/> </glyph> </glyph> <glyph class="macromolecule" id="s11_sa314" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma 1 HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440 References_end</body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="4613.644" y="965.3751"/> <glyph class="state variable" id="_2c46715d-34f0-45d6-94be-4eac26c6402b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4688.644" y="980.3751"/> </glyph> </glyph> <glyph class="macromolecule" id="s2689_sa43" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring-box 1 HUGO:RBX1, HGNC:9928, ENTREZ:9978, UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:NER MODULE:FANCONI Maps_Modules_end References_begin: PMID:15459660 For NER pathway: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For Fanconi pathway: PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="1626.2843" y="6700.44"/> </glyph> <glyph class="macromolecule" id="s1058_sa185" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RecQ protein-like 5 HUGO:RECQL5, HGNC:9950, ENTREZ:9400, UNIPROT:O94762 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:BER Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258,PMID:23161013 Activates BER PMID:22973052 References_end</body> </html> </notes> <label text="RECQL5 "/> <bbox w="80.0" h="40.0" x="7091.6875" y="5078.0"/> </glyph> <glyph class="macromolecule" id="s1267_sa240" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9560.268" y="6389.6475"/> <glyph class="state variable" id="_7031f793-48da-4e6e-b57f-993ca1d247d4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9632.768" y="6424.6475"/> </glyph> <glyph class="state variable" id="_72e33435-0a5a-431d-8df5-51b34c77fcff"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9632.768" y="6404.6475"/> </glyph> <glyph class="state variable" id="_d0afdc3e-7d7e-4bc5-96ad-87137870f993"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9632.768" y="6384.6475"/> </glyph> </glyph> <glyph class="macromolecule" id="s1266_sa239" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9790.768" y="6394.6475"/> <glyph class="state variable" id="_e35fae68-df4e-4331-bbcc-5749c9d0d6cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9865.768" y="6429.6475"/> </glyph> <glyph class="state variable" id="_d86b9546-7426-4e87-9f2c-16e7bb527efe"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9863.268" y="6409.6475"/> </glyph> <glyph class="state variable" id="_8011298d-2116-4d8d-8b2d-7ab749b51484"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9865.768" y="6389.6475"/> </glyph> </glyph> <glyph class="macromolecule" id="s3387_sa14" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication factor C (activator 1) 1, 145kDa HUGO:RFC1, HGNC:9969, ENTREZ:5981, UNIPROT:P35251 replication factor C (activator 1) 2, 40kDa HUGO:RFC2, HGNC:9970, ENTREZ:5982, UNIPROT:P35250 replication factor C (activator 1) 3, 38kDa HUGO:RFC3, HGNC:9971, ENTREZ:5983, UNIPROT:P40938 replication factor C (activator 1) 4, 37kDa HUGO:RFC4, HGNC:9972, ENTREZ:5984, UNIPROT:P35249 replication factor C (activator 1) 5, 36.5kDa HUGO:RFC5, HGNC:9973, ENTREZ:5985, UNIPROT:P40937 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="RFC*"/> <bbox w="80.0" h="40.0" x="4185.7695" y="7003.5"/> </glyph> <glyph class="macromolecule" id="s1447_sa266" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) HUGO:RMI1, HGNC:25764, ENTREZ:80010, UNIPROT:Q9H9A7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:16537486, PMID:19945966, PMID:20826342, PMID:16595695 References_end</body> </html> </notes> <label text="RMI1"/> <bbox w="80.0" h="40.0" x="7427.6064" y="8077.9985"/> </glyph> <glyph class="macromolecule" id="s1086_sa195" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring finger protein 8 HUGO:RNF8, HGNC:10071, ENTREZ:9025, UNIPROT:O76064 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:18006705, PMID:19772495 References_end</body> </html> </notes> <label text="RNF8"/> <bbox w="80.0" h="40.0" x="7343.2686" y="6135.0"/> </glyph> <glyph class="macromolecule" id="s651_sa78" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="5184.042" y="6880.362"/> <glyph class="state variable" id="_945291b9-3e2b-4f04-abdf-8bb671de118a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5176.542" y="6895.362"/> </glyph> </glyph> <glyph class="macromolecule" id="s2886_sa1282" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD21 homolog (S. pombe), hHR21, SCC1 HUGO:RAD21, HGNC:9811, ENTREZ:5885, UNIPROT:O60216 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:1159013 References_end</body> </html> </notes> <label text="SCC1*"/> <bbox w="80.0" h="40.0" x="5241.377" y="2159.8364"/> <glyph class="state variable" id="_9e2783be-6fe5-4c56-9368-20dea6223953"> <state value="" variable="ATM-dep."/> <bbox w="50.0" h="10.0" x="5216.377" y="2174.8047"/> </glyph> <glyph class="state variable" id="_fd53f8fa-aa0f-419f-9a34-d9ad9ad50651"> <state value="P" variable="PLK1-dep."/> <bbox w="60.0" h="10.0" x="5291.377" y="2174.8364"/> </glyph> </glyph> <glyph class="macromolecule" id="s2881_sa1276" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD21 homolog (S. pombe), hHR21, SCC1 HUGO:RAD21, HGNC:9811, ENTREZ:5885, UNIPROT:O60216 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:1159013 References_end</body> </html> </notes> <label text="SCC1*"/> <bbox w="80.0" h="40.0" x="5240.158" y="2315.478"/> <glyph class="state variable" id="_531295f4-5ac3-485b-aae1-6b30da0cbb94"> <state value="" variable="ATM-dep."/> <bbox w="50.0" h="10.0" x="5215.158" y="2330.4463"/> </glyph> <glyph class="state variable" id="_4e546c48-da06-4eb5-8c0f-2d58eaa7115a"> <state value="" variable="PLK1-dep."/> <bbox w="55.0" h="10.0" x="5292.658" y="2330.478"/> </glyph> </glyph> <glyph class="macromolecule" id="s3145_sa1428" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Splicing factor proline/glutamine-rich (SFPQ), Polypyrimidine tract binding protein associated (PSF) HUGO:SFPQ, HGNC:10774, ENTREZ:6421, UNIPROT:P23246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:20813759, PMID:10931916, PMID:15590677, PMID:19759212, PMID:10858305 References_end</body> </html> </notes> <label text="SFPQ"/> <bbox w="80.0" h="40.0" x="7556.1064" y="6810.5"/> </glyph> <glyph class="macromolecule" id="s702_sa86" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: seven in absentia homolog 1 (Drosophila) HUGO:SIAH1, HGNC:10857, ENTREZ:6477, UNIPROT:Q8IUQ4 seven in absentia homolog 2 (Drosophila) HUGO:SIAH2, HGNC:10858, ENTREZ:6478, UNIPROT:O43255 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19788416, PMID:9403064, PMID:21466614, PMID:20682032, PMID:19607803 References_end</body> </html> </notes> <label text="SIAH*"/> <bbox w="80.0" h="40.0" x="3697.795" y="2526.3772"/> <glyph class="state variable" id="_f622b53d-f70d-4b97-966d-21b2a058971b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3746.8635" y="2521.3772"/> </glyph> </glyph> <glyph class="macromolecule" id="s699_sa142" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: seven in absentia homolog 1 (Drosophila) HUGO:SIAH1, HGNC:10857, ENTREZ:6477, UNIPROT:Q8IUQ4 seven in absentia homolog 2 (Drosophila) HUGO:SIAH2, HGNC:10858, ENTREZ:6478, UNIPROT:O43255 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19788416, PMID:9403064, PMID:21466614, PMID:20682032, PMID:19607803 References_end</body> </html> </notes> <label text="SIAH*"/> <bbox w="80.0" h="40.0" x="3858.269" y="2525.9998"/> <glyph class="state variable" id="_1b56e345-04b4-414b-b44c-be36186cdb79"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3909.8376" y="2520.9998"/> </glyph> </glyph> <glyph class="macromolecule" id="s1133_sa217" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1, HGNC:10899, ENTREZ:6500, UNIPROT:P63208 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: Regulates Fanconi pathway in cell cycle dependent manner PMID:19686080, PMID:19622404, PMID:18931676 For checkpoint PMID:15459660 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="3030.019" y="604.12494"/> </glyph> <glyph class="macromolecule" id="s2491_sa1113" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 2 (p45) HUGO:SKP2, HGNC:10901, ENTREZ:6502, UNIPROT:Q13309 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="SKP2"/> <bbox w="80.0" h="40.0" x="3030.269" y="712.37494"/> </glyph> <glyph class="macromolecule" id="s1586_sa297" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GIY-YIG domain containing 1 HUGO:SLX1A, HGNC:20922, ENTREZ:548593, UNIPROT:Q9BQ83 GIY-YIG domain containing 2 GIYD2, HGNC:28748, ENTREZ:79008, UNIPROT:Q9BQ83 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="SLX1*"/> <bbox w="80.0" h="40.0" x="5044.5195" y="7389.0"/> </glyph> <glyph class="macromolecule" id="s1578_sa291" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BTB (POZ) domain containing 12 Structure-specific endonuclease subunit SLX4 HUGO:BTBD12, HGNC:23845, ENTREZ:84464, UNIPROT:Q8IY92 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236, PMID:22101340 References_end</body> </html> </notes> <label text="SLX4*"/> <bbox w="80.0" h="40.0" x="5044.417" y="7327.3086"/> </glyph> <glyph class="macromolecule" id="s1006_sa168" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 HUGO:SMARCAL1, HGNC:11102, ENTREZ:50485, UNIPROT:Q9NZC9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19841479 For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination PMID:19841479, PMID:19793861, PMID:19793862 References_end</body> </html> </notes> <label text="SMARCAL1"/> <bbox w="80.0" h="40.0" x="7347.2686" y="6654.0"/> <glyph class="state variable" id="_a674045a-3886-461f-9e6d-79453bece0be"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7339.7686" y="6668.9683"/> </glyph> </glyph> <glyph class="macromolecule" id="s998_sa169" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 HUGO:SMARCAL1, HGNC:11102, ENTREZ:50485, UNIPROT:Q9NZC9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19841479 For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination PMID:19841479, PMID:19793861, PMID:19793862 References_end</body> </html> </notes> <label text="SMARCAL1"/> <bbox w="80.0" h="40.0" x="7469.8936" y="6652.0166"/> <glyph class="state variable" id="_e0f287fb-b708-4cd2-b0e6-909d5283220a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7464.8936" y="6666.985"/> </glyph> </glyph> <glyph class="macromolecule" id="s2887_sa1283" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 1A HUGO:SMC1A , HGNC:11111, ENTREZ:8243, UNIPROT:Q14683 structural maintenance of chromosomes 1B HUGO:SMC1B , HGNC:11112, ENTREZ:27127 UNIPROT:Q8NDV3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC1*"/> <bbox w="80.0" h="40.0" x="7346.2236" y="5400.655"/> <glyph class="state variable" id="_e9c42e3b-4d5c-42c7-8cee-bb8fbd630670"> <state value="P" variable="S966"/> <bbox w="35.0" h="10.0" x="7350.9697" y="5395.655"/> </glyph> <glyph 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<label text="SMC1*"/> <bbox w="80.0" h="40.0" x="7504.6064" y="5400.0"/> <glyph class="state variable" id="_31749586-4d62-4c20-8196-58be9dfa6df3"> <state value="" variable="S966"/> <bbox w="30.0" h="10.0" x="7511.8525" y="5395.0"/> </glyph> <glyph class="state variable" id="_4732674d-60a5-40d0-bba5-80b638d02de6"> <state value="" variable="S957"/> <bbox w="30.0" h="10.0" x="7541.1206" y="5395.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2888_sa1284" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Structural maintenance of chromosomes 3 HUGO:SMC3, HGNC:2468, ENTREZ:9126, UNIPROT:Q9UQE7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC3"/> <bbox w="80.0" h="40.0" x="7346.2236" y="5456.655"/> <glyph class="state variable" id="_0d95ec39-7591-4b43-b773-787d0b7c17ec"> <state value="P" variable="S1083"/> <bbox w="40.0" h="10.0" x="7379.118" y="5451.655"/> </glyph> </glyph> <glyph class="macromolecule" id="s1013_sa173" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Structural maintenance of chromosomes 3 HUGO:SMC3, HGNC:2468, ENTREZ:9126, UNIPROT:Q9UQE7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC3"/> <bbox w="80.0" h="40.0" x="7504.6064" y="5458.0"/> <glyph class="state variable" id="_e5b613d8-d1e3-4635-965c-a0fdcbcd61c2"> <state value="" variable="S1083"/> <bbox w="35.0" h="10.0" x="7540.001" y="5453.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1017_sa174" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 5 HUGO:SMC5, HGNC:20465, ENTREZ:23137, UNIPROT:Q8IY18 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="SMC5"/> <bbox w="80.0" h="40.0" x="7346.6064" y="5260.0"/> </glyph> <glyph class="macromolecule" id="s1018_sa175" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 6 HUGO:SMC6, HGNC:20466, ENTREZ:79677, UNIPROT:Q96SB8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="SMC6"/> <bbox w="80.0" h="40.0" x="7346.6064" y="5310.0"/> </glyph> <glyph class="macromolecule" id="s3001_sa1377" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: single-strand-selective 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y="8216.499"/> <glyph class="state variable" id="_a1a2b6c6-5e17-4c8c-b5fa-4c694c5b7f27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3967.4768" y="8251.499"/> </glyph> <glyph class="state variable" id="_c4d79c67-2d1d-4f1c-8f82-864945d2129a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3979.3306" y="8211.499"/> </glyph> </glyph> <glyph class="macromolecule" id="s3258_sa1546" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: snail homolog 1 (Drosophila) HUGO:SNAI1, HGNC:11128, ENTREZ:6615, UNIPROT:O95863 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PARP1 poly(ADP)ribosylates SNAI1 and activates it and EMT program PMID:21577210 References_end</body> </html> </notes> <label text="SNAI1"/> <bbox w="80.0" h="40.0" x="4181.077" y="8216.499"/> <glyph class="state variable" id="_9bd0caf6-092d-4156-8568-1a678f4bba75"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4210.6597" y="8251.499"/> </glyph> <glyph class="state variable" id="_53f887c7-335b-4450-95cf-59a2bb88bbbc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4227.5137" y="8211.499"/> </glyph> </glyph> <glyph class="macromolecule" id="s3256_sa1544" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: snail homolog 1 (Drosophila) HUGO:SNAI1, HGNC:11128, ENTREZ:6615, UNIPROT:O95863 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PARP1 poly(ADP)ribosylates SNAI1 and activates it and EMT program PMID:21577210 References_end</body> </html> </notes> <label text="SNAI1"/> <bbox w="80.0" h="40.0" x="4057.4229" y="8216.499"/> <glyph class="state variable" id="_17dd22d3-78da-4d7f-b933-55d50c21968c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4092.0056" y="8251.499"/> </glyph> <glyph class="state variable" id="_b089f917-d0e3-4175-861f-7679a105c73f"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="4101.3594" y="8211.499"/> </glyph> </glyph> <glyph class="macromolecule" id="s1399_sa259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1B, HGNC:17641, ENTREZ:64858, UNIPROT:Q9H816 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20655466, PMID:18469862 References_end</body> </html> </notes> <label text="SNM1B*"/> <bbox w="80.0" h="40.0" x="7432.411" y="8328.284"/> </glyph> <glyph class="macromolecule" id="s2885_sa1281" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: stromal antigen 1 HUGO:STAG1, HGNC:11354, ENTREZ:10274, UNIPROT:Q8WVM7 stromal antigen 2 HUGO:STAG2, HGNC:11355, ENTREZ:10735, UNIPROT:Q8N3U4 stromal antigen 3 HUGO:STAG3, HGNC:11356, ENTREZ:10734, UNIPROT:Q9UJ98 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:CELL_CYCLE MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:11076961 References_end</body> </html> </notes> <label text="STAG*"/> <bbox w="80.0" h="40.0" x="5493.2695" y="2325.0"/> <glyph class="state variable" id="_fb78f577-20a9-43be-8698-f95a4e5ea702"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5565.7695" y="2340.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2882_sa1277" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: stromal antigen 1 HUGO:STAG1, HGNC:11354, ENTREZ:10274, UNIPROT:Q8WVM7 stromal antigen 2 HUGO:STAG2, HGNC:11355, ENTREZ:10735, UNIPROT:Q8N3U4 stromal antigen 3 HUGO:STAG3, HGNC:11356, ENTREZ:10734, UNIPROT:Q9UJ98 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:CELL_CYCLE MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:11076961 References_end</body> </html> </notes> <label text="STAG*"/> <bbox w="80.0" h="40.0" x="5492.158" y="2156.478"/> <glyph class="state variable" id="_c1e6264b-3186-4613-b6a0-66f493780397"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5567.158" y="2171.478"/> </glyph> </glyph> <glyph class="macromolecule" id="s3378_sa1590" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: signal transducer and activator of transcription 3 (acute-phase response factor) HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 Identifiers_end</body> </html> </notes> <label text="STAT3"/> <bbox w="80.0" h="40.0" x="6971.352" y="8099.499"/> <glyph class="state variable" id="_13b82a18-49bd-41ca-aa69-83a4c27ceb2e"> <state value="P" variable="Ser727"/> <bbox w="45.0" h="10.0" x="7002.7744" y="8094.499"/> </glyph> </glyph> <glyph class="macromolecule" id="s2437_sa1037" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pituitary tumor-transforming 1, Securin HUGO:PTTG1, HGNC:9690, ENTREZ:9232, UNIPROT:O95997 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:SPINDLE_CHECKPOINT MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17962814, PMID:11238996, PMID:20691907 References_end</body> </html> </notes> <label text="Securin*"/> <bbox w="80.0" h="40.0" x="3196.769" y="1581.6372"/> <glyph class="state variable" id="_9a5e75c7-e50e-4bb9-89bf-a23d1b8e6c30"> <state value="P" variable="S165"/> <bbox w="35.0" h="10.0" x="3190.7607" y="1576.6372"/> </glyph> </glyph> <glyph class="macromolecule" id="s2387_sa1084" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pituitary tumor-transforming 1, Securin HUGO:PTTG1, HGNC:9690, ENTREZ:9232, UNIPROT:O95997 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:SPINDLE_CHECKPOINT MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17962814, PMID:11238996, PMID:20691907 References_end</body> </html> </notes> <label text="Securin*"/> <bbox w="80.0" h="40.0" x="3195.2036" y="1663.0686"/> <glyph class="state variable" id="_6a52cc5e-83ee-40eb-b28a-5fd898b0d041"> <state value="" variable="S165"/> <bbox w="30.0" h="10.0" x="3191.6953" y="1658.0686"/> </glyph> </glyph> <glyph class="macromolecule" id="s2513_sa1086" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: extra spindle pole bodies homolog 1 (S. cerevisiae), Separin, Separase HUGO:ESPL1, HGNC:16856, ENTREZ:9700, UNIPROT:Q14674 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:12297314, PMID:17604273, PMID:19342897, PMID:20144767, PMID:19758559 References_end</body> </html> </notes> <label text="Separin*"/> <bbox w="80.0" h="40.0" x="3195.769" y="1744.5"/> </glyph> <glyph class="macromolecule" id="s1304_sa252" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thymine-DNA glycosylase HUGO:TDG, HGNC:11700, ENTREZ:6996, UNIPROT:Q13569 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="TDG"/> <bbox w="80.0" h="40.0" x="3476.1687" y="6832.21"/> <glyph class="state variable" id="_671cf9d8-667b-4759-b570-4360a3cff20c"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="3468.6687" y="6838.926"/> </glyph> </glyph> <glyph class="macromolecule" id="s764_sa116" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thymine-DNA glycosylase HUGO:TDG, HGNC:11700, ENTREZ:6996, UNIPROT:Q13569 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="TDG"/> <bbox w="80.0" h="40.0" x="3341.3452" y="6834.067"/> <glyph class="state variable" id="_61d69a63-9ae7-421a-950a-6a3c1b0f7c30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3336.3452" y="6840.7827"/> </glyph> </glyph> <glyph class="macromolecule" id="s516_sa49" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosyl-DNA phosphodiesterase 1 HUGO:TDP1, HGNC:18884, ENTREZ:55775, UNIPROT:Q9NUW8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:11572945, PMID:20009512 References_end</body> </html> </notes> <label text="TDP1"/> <bbox w="80.0" h="40.0" x="2063.769" y="7183.0"/> </glyph> <glyph class="macromolecule" id="s1891_sa339" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 1, 62kDa HUGO:GTF2H1, HGNC:4655, ENTREZ:HGNC:2965, UNIPROT:P32780 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH1*"/> <bbox w="80.0" h="40.0" x="721.1631" y="6187.792"/> </glyph> <glyph class="macromolecule" id="s1892_sa340" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 2, 44kDa HUGO:GTF2H2, HGNC:4656, ENTREZ:2966, UNIPROT:Q13888 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH2*"/> <bbox w="80.0" h="40.0" x="721.1631" y="6235.1255"/> </glyph> <glyph class="macromolecule" id="s1893_sa341" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 3, 34kDa HUGO:GTF2H3, HGNC:4657, ENTREZ:2967, UNIPROT:Q13889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH3*"/> <bbox w="80.0" h="40.0" x="721.1631" y="6282.4585"/> </glyph> <glyph class="macromolecule" id="s1894_sa342" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 4, 52kDa HUGO:GTF2H4, HGNC:4658, ENTREZ:2968, UNIPROT:Q92759 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH4*"/> <bbox w="80.0" h="40.0" x="721.1631" y="6329.792"/> </glyph> <glyph class="macromolecule" id="s1889_sa337" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 5 HUGO:GTF2H5, HGNC:21157, ENTREZ:404672, UNIPROT:Q6ZYL4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH5*"/> <bbox w="80.0" h="40.0" x="625.6633" y="6282.292"/> </glyph> <glyph class="macromolecule" id="s2936_sa1321" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: timeless homolog (Drosophila) HUGO:TIMELESS, HGNC:11813, ENTREZ:8914, UNIPROT:Q9UNS1 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725, PMID:15798197 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIM1*"/> <bbox w="80.0" h="40.0" x="5412.7695" y="3553.5002"/> </glyph> <glyph class="macromolecule" id="s1417_sa260" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: K(lysine) acetyltransferase 5 HUGO:KAT5, HGNC:5275, ENTREZ:10524, UNIPROT:Q92993 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:12551922, PMID:11927554, PMID:21574959, PMID:18085520 References_end</body> </html> </notes> <label text="TIP60*"/> <bbox w="80.0" h="40.0" x="7823.3687" y="7355.0"/> </glyph> <glyph class="macromolecule" id="s2935_sa1320" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TIMELESS interacting protein HUGO:TIPIN, HGNC:30750, ENTREZ:54962, UNIPROT:Q9BVW5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIPIN"/> <bbox w="80.0" h="40.0" x="5317.7695" y="3554.5002"/> </glyph> <glyph class="macromolecule" id="s3347_sa1563" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (PARP5) HUGO:TNKS, HGNC:11941, ENTREZ:8658, UNIPROT:O95271 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: Tankyrase in telomere maintenance PMID:21818122, PMID:21076181, PMID:21037379, PMID:18835851 Tankyrase for WNT activation PMID:23197039, PMID:22738915, PMID:23144924, PMID:23148305, PMID:22440753 Tankyrase activated spindle checkpoint PMID:23197039 PARPs in cellular functions PMID:22713970 References_end</body> </html> </notes> <label text="TNKS1*"/> <bbox w="80.0" h="40.0" x="2533.769" y="7602.5"/> </glyph> <glyph class="macromolecule" id="s1059_sa186" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: topoisomerase (DNA) III alpha HUGO:TOP3A, HGNC:11992, ENTREZ:7156, UNIPROT:Q13472 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="TOP3A"/> <clone/> <bbox w="80.0" h="40.0" x="7427.6064" y="8119.999"/> </glyph> <glyph class="macromolecule" id="s1059_sa220" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: topoisomerase (DNA) III alpha HUGO:TOP3A, HGNC:11992, ENTREZ:7156, UNIPROT:Q13472 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="TOP3A"/> <clone/> <bbox w="80.0" h="40.0" x="8733.229" y="7947.2793"/> </glyph> <glyph class="macromolecule" id="s1934_sa351" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: topoisomerase (DNA) II binding protein 1 HUGO:TOPBP1, HGNC:17008, ENTREZ:11073, UNIPROT:Q92547 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:17303408, PMID:16530042 References_end</body> </html> </notes> <label text="TOPBP1"/> <bbox w="80.0" h="40.0" x="5757.019" y="3140.5002"/> </glyph> <glyph class="macromolecule" id="s1498_sa274" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor protein p53 binding protein 1 HUGO:TP53BP1, HGNC:11999, ENTREZ:7158, UNIPROT:Q12888 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:9748285, PMID:11042216, PMID:20646866, PMID:11877378 53BP1* binds to DNA and stops DNA resection and therefore stops HR during cell cycle exept S-pthase, because 53BP1* is phosphorylated by CDK1(CDC2) during S-phase, this phosphorylation inhibits 53BP1* activity PMID:17243194 References_end</body> </html> </notes> <label text="TP53BP1"/> <bbox w="80.0" h="40.0" x="7250.2686" y="5126.0"/> <glyph class="state variable" id="_dc16a689-8294-44bf-a7ba-c3d3cedf9b3d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7242.7686" y="5141.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s1497_sa275" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor protein p53 binding protein 1 HUGO:TP53BP1, HGNC:11999, ENTREZ:7158, UNIPROT:Q12888 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:9748285, PMID:11042216, PMID:20646866, PMID:11877378 53BP1* binds to DNA and stops DNA resection and therefore stops HR during cell cycle exept S-pthase, because 53BP1* is phosphorylated by CDK1(CDC2) during S-phase, this phosphorylation inhibits 53BP1* activity PMID:17243194 References_end</body> </html> </notes> <label text="TP53BP1"/> <bbox w="80.0" h="40.0" x="7090.0186" y="5131.7144"/> <glyph class="state variable" id="_1ee1027f-fb15-43e4-81af-457a69136d46"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7085.0186" y="5146.7144"/> </glyph> </glyph> <glyph class="macromolecule" id="s3049_sa1408" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: deoxynucleotidyltransferase, terminal, TdT HUGO:DNTT, HGNC:2983, ENTREZ:1791, UNIPROT:P04053 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17631059, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="TdT* "/> <bbox w="80.0" h="40.0" x="5709.731" y="7550.064"/> </glyph> <glyph class="macromolecule" id="s3035_sa1394" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Transcription complex Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="Transcription machine (RNAPII)*"/> <bbox w="123.0" h="40.0" x="7.269287" y="6638.5"/> <glyph class="state variable" id="_33a9a672-d407-47d4-9ca4-3aad6761aecd"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="-2.730713" y="6654.2686"/> </glyph> </glyph> <glyph class="macromolecule" id="s1127_sa213" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WD repeat domain 48, USP1 associated factor 1 HUGO:WDR48, HGNC:30914, ENTREZ:57599, UNIPROT:Q8TAF3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: For UAF1 PMID:19264559, PMID:19075014 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="UAF1*"/> <bbox w="80.0" h="40.0" x="9391.443" y="7395.8896"/> </glyph> <glyph class="macromolecule" id="s1272_sa235" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2 variant 2 HUGO:UBE2V2, HGNC:12495, ENTREZ:7336, UNIPROT:Q15819 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:20675655, PMID:16518696, PMID:18525240, PMID:18157158, PMID:19258535, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="UBC12*"/> <bbox w="80.0" h="40.0" x="9883.269" y="6875.0"/> </glyph> <glyph class="macromolecule" id="s1274_sa236" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) HUGO:UBE2N, HGNC:12492, ENTREZ:7334, UNIPROT:P61088 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="UBE2N"/> <bbox w="80.0" h="40.0" x="7092.2686" y="6457.0"/> </glyph> <glyph class="macromolecule" id="s1435_sa264" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2T (putative) HUGO:UBE2T, HGNC:25009, ENTREZ:29089, UNIPROT:Q9NPD8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:NER Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Link between Fanconi and NER PMID:22615860 References_end</body> </html> </notes> <label text="UBE2T"/> <bbox w="80.0" h="40.0" x="9450.469" y="7602.461"/> <glyph class="state variable" id="_75ec4ebf-1130-429d-8342-cfe42b900eeb"> <state value="Ub" variable="k91"/> <bbox w="35.0" h="10.0" x="9455.944" y="7637.461"/> </glyph> </glyph> <glyph class="macromolecule" id="s1183_sa224" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2T (putative) HUGO:UBE2T, HGNC:25009, ENTREZ:29089, UNIPROT:Q9NPD8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:NER Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Link between Fanconi and NER PMID:22615860 References_end</body> </html> </notes> <label text="UBE2T"/> <bbox w="80.0" h="40.0" x="9301.268" y="7603.0"/> <glyph class="state variable" id="_3fa497d5-1cfc-4761-957d-ff00eb5ee234"> <state value="" variable="k91"/> <bbox w="25.0" h="10.0" x="9311.743" y="7638.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s2999_sa1375" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: uracil-DNA glycosylase HUGO:UNG, HGNC:12572, ENTREZ:7374, UNIPROT:P13051 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="UNG"/> <bbox w="80.0" h="40.0" x="3174.269" y="6498.5"/> </glyph> <glyph class="macromolecule" id="s3382_sa214" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 1 HUGO:USP1, HGNC:12607, ENTREZ:7398, UNIPROT:O94782 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Stabilisation by phosphorylaton by CDK5 PMID:23589330 References_end</body> </html> </notes> <label text="USP1"/> <bbox w="80.0" h="40.0" x="9391.443" y="7345.8896"/> <glyph class="state variable" id="_7d6a3985-ea66-4e26-97fc-a71f7f0c337c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9430.026" y="7340.8896"/> </glyph> </glyph> <glyph class="macromolecule" id="s1126_sa1593" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 1 HUGO:USP1, HGNC:12607, ENTREZ:7398, UNIPROT:O94782 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Stabilisation by phosphorylaton by CDK5 PMID:23589330 References_end</body> </html> </notes> <label text="USP1"/> <bbox w="80.0" h="40.0" x="9387.436" y="7234.0"/> <glyph class="state variable" id="_e2e28b52-c3e3-4cae-b06f-8db9e05cc0f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9428.519" y="7229.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3434_sa317" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WEE1 homolog (S. pombe) HUGO:WEE1, HGNC:12761, ENTREZ:7465, UNIPROT:P30291 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="WEE1"/> <bbox w="80.0" h="40.0" x="4647.019" y="270.37503"/> <glyph class="state variable" id="_653ede12-6b00-47df-ad69-182e41cfcb08"> <state value="P" variable="CHEK1site"/> <bbox w="60.0" h="10.0" x="4654.6206" y="265.37503"/> </glyph> <glyph class="state variable" id="_ab9b91ad-9f96-45d1-87ae-11261ce18084"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4642.019" y="285.37503"/> </glyph> </glyph> <glyph class="macromolecule" id="s3433_sa1623" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WEE1 homolog (S. pombe) HUGO:WEE1, HGNC:12761, ENTREZ:7465, UNIPROT:P30291 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="WEE1"/> <bbox w="80.0" h="40.0" x="4499.7695" y="276.5"/> <glyph class="state variable" id="_9e819ea4-3856-409a-8481-f3fe7611fec8"> <state value="" variable="CHEK1site"/> <bbox w="55.0" h="10.0" x="4509.871" y="271.5"/> </glyph> <glyph class="state variable" id="_b6e5ec50-fb65-4e34-8a62-ca219a8ede68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4494.7695" y="291.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s73_sa322" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WEE1 homolog (S. pombe) HUGO:WEE1, HGNC:12761, ENTREZ:7465, UNIPROT:P30291 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="WEE1"/> <bbox w="80.0" h="40.0" x="4793.019" y="269.87503"/> <glyph class="state variable" id="_a8c5f01e-2613-4c1c-8932-0ae5a0d8ce82"> <state value="" variable="CHEK1site"/> <bbox w="55.0" h="10.0" x="4803.1206" y="264.87503"/> </glyph> <glyph class="state variable" id="_12475b87-2ae2-420b-8717-21617e00ef80"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4785.519" y="284.87503"/> </glyph> </glyph> <glyph class="macromolecule" id="s3381_sa1592" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="7318.587" y="7994.4077"/> <glyph class="state variable" id="_fdcf9041-44c4-443e-9000-52bce3db3308"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="7349.8345" y="7989.4077"/> </glyph> </glyph> <glyph class="macromolecule" id="s3174_sa1456" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="2248.8547" y="7810.417"/> <glyph class="state variable" id="_22f21297-ed8b-441e-b2fc-92b526c2783e"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="2277.6025" y="7805.417"/> </glyph> </glyph> <glyph class="macromolecule" id="s1544_sa288" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XPA binding protein 2 HUGO:XAB2, HGNC:14089, ENTREZ:56949, UNIPROT:Q9HCS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XAB2"/> <bbox w="80.0" h="40.0" x="1031.4514" y="6807.139"/> </glyph> <glyph class="macromolecule" id="s3384_sa127" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XLF nonhomologous end-joining factor 1 HUGO:C_NHEJ1, HGNC:25737, ENTREZ:79840, UNIPROT:Q9H9Q4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:16439205 References_end</body> </html> </notes> <label text="XLF*"/> <bbox w="80.0" h="40.0" x="6115.3066" y="7691.4077"/> </glyph> <glyph class="macromolecule" id="s1545_sa287" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group A HUGO:XPA, HGNC:12814, ENTREZ:7507, UNIPROT:P23025 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470 PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPA"/> <bbox w="80.0" h="40.0" x="1033.4514" y="6748.139"/> <glyph class="state variable" id="_1520b07d-aa96-426a-b2ea-2f26364461da"> <state value="P" variable="S196"/> <bbox w="35.0" h="10.0" x="1015.9514" y="6754.6455"/> </glyph> </glyph> <glyph class="macromolecule" id="s1543_sa289" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group A HUGO:XPA, HGNC:12814, ENTREZ:7507, UNIPROT:P23025 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470 PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPA"/> <bbox w="80.0" h="40.0" x="1034.4515" y="6669.139"/> <glyph class="state variable" id="_139bbdfb-6398-4232-8ba7-9ceddabf6e98"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="1019.45154" y="6675.6455"/> </glyph> </glyph> <glyph class="macromolecule" id="s1887_sa335" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) HUGO:ERCC3, HGNC:3435, ENTREZ:2071, UNIPROT:P19447 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPB*"/> <bbox w="80.0" h="40.0" x="625.6633" y="6187.292"/> </glyph> <glyph class="macromolecule" id="s206_sa31" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group C HUGO:XPC, HGNC:12816, ENTREZ:7508, UNIPROT:Q01831 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPC"/> <bbox w="80.0" h="40.0" x="3341.3452" y="6775.0"/> </glyph> <glyph class="macromolecule" id="s1888_sa336" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 2 HUGO:ERCC2, HGNC:3434, ENTREZ:2068, UNIPROT:P18074 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPD*"/> <bbox w="80.0" h="40.0" x="625.6633" y="6234.792"/> </glyph> <glyph class="macromolecule" id="s891_sa36" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 4 HUGO:ERCC4, HGNC:3436, ENTREZ:2072, UNIPROT:Q92889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:22101340, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For Fanconi pathway PMID:19686080 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XPF*"/> <bbox w="80.0" h="40.0" x="1062.8796" y="7197.068"/> </glyph> <glyph class="macromolecule" id="s893_sa35" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 5 HUGO:ERCC5, HGNC:3437, ENTREZ:2073, UNIPROT:P28715 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPG*"/> <bbox w="80.0" h="40.0" x="2258.269" y="6599.0"/> </glyph> <glyph class="macromolecule" id="s731_sa28" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="2261.8113" y="7907.567"/> <glyph class="state variable" id="_b1560b44-6af0-49fd-b6cd-57d0d66ab036"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2310.88" y="7902.567"/> </glyph> </glyph> <glyph class="macromolecule" id="s191_sa108" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="2420.8564" y="7908.11"/> <glyph class="state variable" id="_d15e06d1-1680-4271-b927-a463b8e17ef9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2472.425" y="7903.11"/> </glyph> </glyph> <glyph class="macromolecule" id="s1071_sa191" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 2 HUGO:XRCC2, HGNC:12829, ENTREZ:7516, UNIPROT:O43543 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC2"/> <bbox w="80.0" h="40.0" x="7823.3687" y="7176.0"/> </glyph> <glyph class="macromolecule" id="s1076_sa192" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 3 HUGO:XRCC3, HGNC:12830, ENTREZ:7517, UNIPROT:O43542 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC3"/> <bbox w="80.0" h="40.0" x="7346.6064" y="5809.0"/> </glyph> <glyph class="macromolecule multimer" id="s3386_sa129" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing 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<label text="S phase"/> <bbox w="132.0" h="28.0" x="4834.269" y="3996.0"/> </glyph> <glyph class="phenotype" id="s3265_sa1553" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Link to Telomere maintenance map Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:21818122, PMID:21076181, PMID:21037379 References_end</body> </html> </notes> <label text="Telomere maintenance"/> <bbox w="158.0" h="27.0" x="3449.769" y="8311.498"/> </glyph> <glyph class="phenotype" id="s3253_sa1541" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:DR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="Toxic compounds"/> <bbox w="140.0" h="32.0" x="3653.769" y="5300.5"/> </glyph> <glyph class="phenotype" id="s3348_sa1564" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Link to Cell survival map Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:23197039, PMID:22738915, PMID:23144924, PMID:23148305, PMID:22440753 References_end</body> </html> </notes> <label text="WNT pathway"/> <bbox w="200.0" h="33.0" x="3842.769" y="8311.498"/> </glyph> <glyph class="simple chemical" id="s125_sa22" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="Mg2+"/> <bbox w="35.0" h="31.0" x="2189.8115" y="7219.5674"/> </glyph> <glyph class="nucleic acid feature" id="s1709_sa119" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C_NHEJ:DNA:st1 DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22258607, PMID:22918414, PMID:20691907, PMID:23897299, PMID:23892398, PMID:23760025, PMID:24050180 Double strand break triggers MRN complex association:first step in DNA damage recognition and initiation of G2/M checkpoint PMID:17303408 C_NHEJ in dividing and non-dividing cells PMID:23684800 References_end</body> </html> </notes> <label text=" C_NHEJ_DNA_st1*"/> <bbox w="150.0" h="26.0" x="5406.9736" y="6584.988"/> </glyph> <glyph class="nucleic acid feature" id="s2529_sa1145" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB, HGNC:12849, ENTREZ:7529 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG, HGNC:12852, ENTREZ:7532 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH, HGNC:12853, ENTREZ:7533 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE, HGNC:12851, ENTREZ:7531 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ, HGNC:12854, ENTREZ:10971 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ, HGNC:12855, ENTREZ:7534 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="70.0" h="25.0" x="7760.7686" y="2071.0"/> </glyph> <glyph class="nucleic acid feature" id="s3427_sa1617" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:23892398 References_end</body> </html> </notes> <label text="6-4_phosphoproducts*"/> <bbox w="241.0" h="26.0" x="1418.7689" y="6366.0"/> </glyph> <glyph class="nucleic acid feature" id="s3422_sa1612" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:23892398 For A_NHEJ: PMID:22258607, PMID:22918414, PMID:21376743, PMID:24050180, PMID:22743550, PMID:23897299 Double strand break trigers MRN complex association, the first step in DNA damage recognition and initiation of G2/M checkpoint PMID:17303408 References_end</body> </html> </notes> <label text="A_NHEJ_DNA_st1*"/> <bbox w="150.0" h="26.0" x="6230.926" y="6528.0"/> </glyph> <glyph class="nucleic acid feature" id="s1713_sa144" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Additional pathway names: alternative NHEJ (A_NHEJ or alt_NHEJ) or backup NHEJ (B_NHEJ) or MMEJ A_NHEJ:DNA:st2 Resected DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="A_NHEJ_DNA_st2*"/> <bbox w="150.0" h="26.0" x="6230.926" y="6863.2725"/> </glyph> <glyph class="nucleic acid feature" id="s1714_sa162" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Additional pathway names: alternative NHEJ (A_NHEJ or alt_NHEJ) or backup NHEJ (B_NHEJ) or MMEJ A_NHEJ:DNA:st3 Annealed DNA using microhomology sequences with branched un-annealed ends Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="A_NHEJ_DNA_st3*"/> <bbox w="150.0" h="26.0" x="6230.926" y="7103.7456"/> </glyph> <glyph class="nucleic acid feature" id="s1715_sa163" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Additional pathway names: alternative NHEJ (A_NHEJ or alt_NHEJ) or backup NHEJ (B_NHEJ) or MMEJ A_NHEJ:DNA:st4 Annealed and resected DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="A_NHEJ_DNA_st4*"/> <bbox w="150.0" h="26.0" x="6230.926" y="7332.2188"/> </glyph> <glyph class="nucleic acid feature" id="s1716_sa271" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Additional pathway names: alternative NHEJ (A_NHEJ or alt_NHEJ) or backup NHEJ (B_NHEJ) or MMEJ A_NHEJ:DNA:st5 Gap filled DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="A_NHEJ_DNA_st5*"/> <bbox w="150.0" h="26.0" x="6230.926" y="7638.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3160_sa1444" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Additional pathway names: alternative NHEJ (A_NHEJ or alt_NHEJ) or backup NHEJ (B_NHEJ) or MMEJ A_NHEJ:DNA:st6 Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="A_NHEJ_DNA_st6*"/> <bbox w="150.0" h="26.0" x="6230.926" y="7885.0005"/> </glyph> <glyph class="nucleic acid feature" id="s1698_sa306" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BER:B-glyc:DNA:st2 Base-free DNA containing an apurinic/apyrimidinic (AP) site Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:DR Maps_Modules_end</body> </html> </notes> <label text="BER_B-glyc_DNA_st2*"/> <bbox w="150.0" h="26.0" x="1746.6428" y="6909.6787"/> </glyph> <glyph class="nucleic acid feature" id="s1693_sa18" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BER:B-glyc:DNA:st3 DNA with 3'ddR5P DNA with ssb Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="BER_B-glyc_DNA_st3*"/> <bbox w="150.0" h="26.0" x="1746.6428" y="7146.5586"/> </glyph> <glyph class="nucleic acid feature" id="s2998_sa2" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BER:M-glyc:DNA:st2 Base-free DNA containing an apurinic/apyrimidinic (AP) site Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:DR Maps_Modules_end</body> </html> </notes> <label text="BER_M-glyc_DNA_st2*"/> <bbox w="150.0" h="26.0" x="2853.334" y="6785.338"/> </glyph> <glyph class="nucleic acid feature" id="s3021_sa5" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BER:M-glyc:DNA:st3 5'dRP and 3'OH DNA with ssb, containing incision in AP site Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="BER_M-glyc_DNA_st3*"/> <bbox w="150.0" h="26.0" x="2853.334" y="7048.8765"/> </glyph> <glyph class="nucleic acid feature" id="s1541_sa285" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1812.1249"/> </glyph> <glyph class="nucleic acid feature" id="s2590_sa1187" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog (yeast) HUGO:BUB1, HGNC:1148, ENTREZ:699 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:9790499 References_end</body> </html> </notes> <label text="BUB1"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1164.9376"/> </glyph> <glyph class="nucleic acid feature" id="s3428_sa1618" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:DR MODULE:TLS Maps_Modules_end References_begin: PMID:23892398 References_end</body> </html> </notes> <label text="Bbulky_adducts*"/> <bbox w="234.0" h="28.0" x="1014.76904" y="6265.0"/> </glyph> <glyph class="nucleic acid feature" id="s2290_sa930" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="70.0" h="25.0" x="7760.2686" y="776.625"/> </glyph> <glyph class="nucleic acid feature" id="s2510_sa1131" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 25 homolog A (S. pombe) HUGO:CDC25A, HGNC:1725, ENTREZ:993 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25A"/> <bbox w="70.0" h="25.0" x="7760.2686" y="906.06256"/> </glyph> <glyph class="nucleic acid feature" id="s3063_sa1416" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1682.6875"/> </glyph> <glyph class="nucleic acid feature" id="s2178_sa840" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A, HGNC:1784, ENTREZ:1026 cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B, HGNC:1785, ENTREZ:1027 cyclin-dependent kinase inhibitor 1C (p57, Kip2) HUGO:CDKN1C, HGNC:1786, ENTREZ:1028 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CIP/KIP*"/> <bbox w="70.0" h="25.0" x="7770.7686" y="388.3125"/> </glyph> <glyph class="nucleic acid feature" id="s1710_sa267" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C_NHEJ:DNA:st2 Recognized DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:24050180 References_end</body> </html> </notes> <label text="C_NHEJ_DNA_st2*"/> <bbox w="150.0" h="26.0" x="5406.9736" y="6823.2944"/> </glyph> <glyph class="nucleic acid feature" id="s3185_sa1466" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C_NHEJ:DNA:st3 Recognized end processed DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:24050180 References_end</body> </html> </notes> <label text="C_NHEJ_DNA_st3*"/> <bbox w="150.0" h="26.0" x="5406.9736" y="7338.0"/> </glyph> <glyph class="nucleic acid feature" id="s1711_sa122" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C_NHEJ:DNA:st4 DNA with processed (ligatable) ends, gap-filled by POLG or POLM Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:24050180 References_end</body> </html> </notes> <label text="C_NHEJ_DNA_st4*"/> <bbox w="150.0" h="26.0" x="5406.9736" y="7647.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3159_sa1443" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C_NHEJ:DNA:st5 Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:24050180 References_end</body> </html> </notes> <label text="C_NHEJ_DNA_st5*"/> <bbox w="150.0" h="26.0" x="5406.9736" y="7876.0005"/> </glyph> <glyph class="nucleic acid feature" id="s2068_sa361" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin A1 HUGO:CCNA1, HGNC:1577, ENTREZ:8900 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinA1*"/> <bbox w="70.0" h="25.0" x="7770.7686" y="129.43756"/> </glyph> <glyph class="nucleic acid feature" id="s2184_sa842" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin B1 HUGO:CCNB1, HGNC:1579, ENTREZ:891 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="70.0" h="25.0" x="7760.2686" y="647.18744"/> </glyph> <glyph class="nucleic acid feature" id="s2504_sa1126" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="70.0" h="25.0" x="7770.7686" y="517.74994"/> </glyph> <glyph class="nucleic acid feature" id="s2054_sa359" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1, HGNC:1589, ENTREZ:898 cyclin E2 HUGO:CCNE2, HGNC:1590, ENTREZ:9134 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="70.0" h="25.0" x="7770.7686" y="25.0"/> </glyph> <glyph class="nucleic acid feature" id="s1537_sa281" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 2, 48kDa HUGO:DDB2, HGNC:2718, ENTREZ:1643 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB2"/> <bbox w="70.0" h="25.0" x="7761.7686" y="1549.0"/> </glyph> <glyph class="nucleic acid feature" id="s3201_sa1479" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DR:DNA:st1 Direct reversal Alkylated/methylated DNA or pyrimidine dimers Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:DR Maps_Modules_end References_begin: PMID:22258607, PMID:22918414, PMID:21701511, PMID:23892398 References_end</body> </html> </notes> <label text="DR_DNA_st1*"/> <bbox w="120.0" h="26.0" x="9995.269" y="6419.0"/> </glyph> <glyph class="nucleic acid feature" id="s3202_sa1480" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DR:DNA:st2 Direct reversal Repared DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:DR Maps_Modules_end</body> </html> </notes> <label text="DR_DNA_st2*"/> <bbox w="120.0" h="26.0" x="9995.269" y="6609.0"/> </glyph> <glyph class="nucleic acid feature" id="s2967_sa228" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damaged DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR Maps_Modules_end References_begin: PMID:23892398 References_end</body> </html> </notes> <label text="Damaged_DNA*"/> <bbox w="315.0" h="32.0" x="4655.269" y="5714.5"/> </glyph> <glyph class="nucleic acid feature" id="s1694_sa1" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA with deaminated, alkylated, mistmached base Damage caused by Alkylating agents or x-rays Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:23892398 PMID:22258607, PMID:22918414 PMID:23473643, PMID:23408852 References_end</body> </html> </notes> <label text="Deaminated_alkylated_mismatched_base*"/> <bbox w="342.0" h="29.0" x="2755.334" y="6483.8"/> </glyph> <glyph class="nucleic acid feature" id="s3432_sa1622" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ MODULE:SSA Maps_Modules_end References_begin: PMID:23892398, PMID:23804754 Node_Type:Generic References_end</body> </html> </notes> <label text="Double_strand_breaks_DSB*"/> <bbox w="245.0" h="22.0" x="4900.7695" y="6267.0"/> </glyph> <glyph class="nucleic acid feature" id="s1725_sa196" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi:DNA:st1 DNA with inter chromasomal crosslinks (ICL) and/or stalled replication fork and/or intrachromasomal crosslinks induced by X rays or UV light or alkylators (cisplatin, mitomycin C, nitrogen mustard) Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:22258607, PMID:22918414 PMID:23444773, PMID:23637285, PMID:23892398 For activation of Fanconi by UV light PMID:17145857, PMUID:22751496 Fanconi is activated by interstrand crosslinking agents PMID:23444773, PMID:21948210, PMID:21701511 References_end</body> </html> </notes> <label text="Fanconi_DNA_st1*"/> <bbox w="120.0" h="26.0" x="8369.861" y="6101.286"/> </glyph> <glyph class="nucleic acid feature" id="s1726_sa257" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi:DNA:st2 Recognised DNA with inter chromasomal crosslinks (ICL) and/or stalled replication fork Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:21948210 References_end</body> </html> </notes> <label text="Fanconi_DNA_st2*"/> <bbox w="120.0" h="26.0" x="8374.611" y="6568.1094"/> </glyph> <glyph class="nucleic acid feature" id="s1727_sa221" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi:DNA:st3 Reversed-fork structured DNA with inter chromasomal crosslinks (ICL) and/or stalled replication fork Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:21948210 References_end</body> </html> </notes> <label text="Fanconi_DNA_st3*"/> <bbox w="120.0" h="26.0" x="8374.611" y="6771.0356"/> </glyph> <glyph class="nucleic acid feature" id="s1728_sa226" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi:DNA:st4 Reversed-fork structured DNA with unhooked and insices inter chromasomal crosslinks (ICL) region Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="Fanconi_DNA_st4*"/> <bbox w="120.0" h="26.0" x="8374.611" y="7346.9746"/> </glyph> <glyph class="nucleic acid feature" id="s1729_sa227" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi:DNA:st5 DNA with filled gaps using bipass-mechanism (trans lesion repair-TLS) Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="Fanconi_DNA_st5*"/> <bbox w="120.0" h="26.0" x="8374.611" y="7557.17"/> </glyph> <glyph class="nucleic acid feature" id="s1535_sa279" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Growth arrest and DNA-damage-inducible, alpha HUGO:GADD45A, HGNC:4095, ENTREZ:1647 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:NER Maps_Modules_end References_begin: PMID:19004803 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1294.375"/> </glyph> <glyph class="nucleic acid feature" id="s1684_sa30" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GG-NER:DNA:st1 Transcriptionally silent chemically or stracturally modyfied DNA Damage types are bulky adducts, 6-4 phosphoproducts, cyclobutane, pyrimidine dimer, methylated bases caused by UV light, hydrocarbons, alkylators Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:23892398 PMID:20211143, PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 ROS activate NER for repating intrastrand crosslink PMID:22581771 ROS activate NER for bulky adducts PMID:18189366 References_end</body> </html> </notes> <label text="GG-NER_DNA_st1*"/> <bbox w="170.0" h="26.0" x="1182.7733" y="6555.8"/> </glyph> <glyph class="nucleic acid feature" id="s1685_sa299" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GG-NER:DNA:st2 Transcriptionally silent chemically or stracturally modyfied DNA, damage-recognition Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="GG-NER_DNA_st2*"/> <bbox w="170.0" h="26.0" x="1179.7733" y="6924.8"/> </glyph> <glyph class="nucleic acid feature" id="s1717_sa152" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st1 DNA with double strand break or interstrand crosslink (ICL) Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:22258607, PMID:22918414, PMID:20723763 PMID:22920291, PMID:23897299, PMID:23892398, HR in dividing and non-dividing cells PMID:23684800 Double strand break trigers MRN complex association:first step in DNA damage recognition and initiation of G2/M checkpoint PMID:17303408 Interstrand crosslinking agents activate HR PMID:21701511 Ends resection PMID:21910633 HR as part of stalled replication fork resolution PMID:23637285 References_end</body> </html> </notes> <label text="HR_DNA_st1*"/> <bbox w="120.0" h="26.0" x="6738.832" y="5179.8"/> </glyph> <glyph class="nucleic acid feature" id="s1718_sa153" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st2 Resected DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="HR_DNA_st2*"/> <bbox w="120.0" h="26.0" x="6738.832" y="6494.9746"/> </glyph> <glyph class="nucleic acid feature" id="s1719_sa177" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st3 Resected DNA with RAD51 filaments Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="HR_DNA_st3*"/> <bbox w="120.0" h="26.0" x="6738.832" y="7500.8438"/> </glyph> <glyph class="nucleic acid feature" id="s1720_sa182" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st4 Synaptic stable pairing/D-loop structure formation between recombining DNA molecules(strand invasion, branches migration) followed by pairing between invading strand and complementary heteroduplex strand Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="HR_DNA_st4*"/> <bbox w="120.0" h="26.0" x="6738.832" y="7756.461"/> </glyph> <glyph class="nucleic acid feature" id="s1721_sa181" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st5 Gap filling: DNA with D-loop structure with extended pairing between invading strand and complementary heteroduplex strand and containing newly synthesized ends Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="HR_DNA_st5*"/> <bbox w="120.0" h="26.0" x="6738.832" y="7920.078"/> </glyph> <glyph class="nucleic acid feature" id="s3050_sa183" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st6 DNA after branches migration (non-cross-over mechanism) or DNA after sister chromatid exchange (SCE)-cross-over mechanism Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="HR_DNA_st6*"/> <bbox w="120.0" h="26.0" x="6738.832" y="8163.9873"/> </glyph> <glyph class="nucleic acid feature" id="s3161_sa1445" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HR:DNA:st7 Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="HR_DNA_st7*"/> <bbox w="120.0" h="26.0" x="6738.832" y="8274.999"/> </glyph> <glyph class="nucleic acid feature" id="s2502_sa1124" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), p16INK4A, p19ARF HUGO:CDKN2A, HGNC:1787, ENTREZ:1029 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), p15INK4b HUGO:CDKN2B, HGNC:1788, ENTREZ:1030 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), INK4C HUGO:CDKN2C, HGNC:1789, ENTREZ:1031 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4), INK4D HUGO:CDKN2D, NC:1790, ENTREZ:1032 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="INK4*"/> <bbox w="70.0" h="25.0" x="7770.7686" y="258.87503"/> </glyph> <glyph class="nucleic acid feature" id="s3235_sa1496" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Undamaged DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:NER MODULE:MMR MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ MODULE:FANCONI MODULE:TLS MODULE:SSA MODULE:DR Maps_Modules_end References_begin: PMID:23892398 References_end</body> </html> </notes> <label text="Intact_DNA*"/> <bbox w="217.0" h="25.0" x="4704.269" y="5855.0"/> </glyph> <glyph class="nucleic acid feature" id="s3424_sa1614" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: Node_Type:Generic PMID:23892398 References_end</body> </html> </notes> <label text="Interstrand_crosslinks_ICL*"/> <bbox w="241.0" h="26.0" x="4692.269" y="6035.0"/> </glyph> <glyph class="nucleic acid feature" id="s3423_sa1613" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: Node_Type:Generic PMID:23892398 References_end</body> </html> </notes> <label text="Intrastrand_crosslinks*"/> <bbox w="231.0" h="24.0" x="4563.769" y="6267.0"/> </glyph> <glyph class="nucleic acid feature" id="s3025_sa1392" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: LnP:BER:M-glyc:st4 Long patch BER: multiple-nucleotide patch replacement pathway DNA with ssb containing replaced unligated multiple-nucleotide patch Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="LnP_BER_M-glyc_st4*"/> <bbox w="150.0" h="26.0" x="2853.334" y="7357.5957"/> </glyph> <glyph class="nucleic acid feature" id="s3026_sa8" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: LnP:BER:M-glyc:st5 Long patch BER:multiple nucleotide patch replacement pathway Gap filled end processed DNA containing unligated DNA patch Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="LnP_BER_M-glyc_st5*"/> <bbox w="150.0" h="26.0" x="2853.334" y="7702.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3156_sa1438" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: LnP:BER:M-glyc:st6 Long patch BER: multiple nucleotide patch replacement pathway Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="LnP_BER_M-glyc_st6*"/> <bbox w="150.0" h="26.0" x="2853.334" y="7953.333"/> </glyph> <glyph class="nucleic acid feature" id="s2589_sa1186" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD2 mitotic arrest deficient-like 1 (yeast) HUGO:MAD2L1, HGNC:6763, ENTREZ:4085 MAD2 mitotic arrest deficient-like 2 (yeast) HUGO:MAD2L2, HGNC:6764, ENTREZ:10459 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:8824189, PMID:17498870, PMID:15024386, PMID:18022367 References_end</body> </html> </notes> <label text="MAD2*"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1035.5001"/> </glyph> <glyph class="nucleic acid feature" id="s1706_sa51" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MMR:DNA:st2 3' and 5' incised-nicked DNA with mismatched nucleotide incorporation Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MMR_DNA_st2*"/> <bbox w="120.0" h="26.0" x="3658.9604" y="6805.5293"/> </glyph> <glyph class="nucleic acid feature" id="s1707_sa53" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MMR:DNA:st3 DNA with excised DNA fragment Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MMR_DNA_st3*"/> <bbox w="120.0" h="26.0" x="3658.9604" y="7048.259"/> </glyph> <glyph class="nucleic acid feature" id="s1708_sa268" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MMR:DNA:st4 DNA with newly synthesized un-ligated DNA fragment Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MMR_DNA_st4*"/> <bbox w="120.0" h="26.0" x="3658.9604" y="7307.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3157_sa1440" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MMR:DNA:st5 Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MMR_DNA_st5*"/> <bbox w="120.0" h="26.0" x="3658.9604" y="7475.3335"/> </glyph> <glyph class="nucleic acid feature" id="s3431_sa1621" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:DR Maps_Modules_end References_begin: DNA with methylated guanine or adenine or cytosine Node_Type:Generic PMID:23892398 References_end</body> </html> </notes> <label text="Methylated_base*"/> <bbox w="173.0" h="27.0" x="9968.769" y="6277.0"/> </glyph> <glyph class="nucleic acid feature" id="s1705_sa52" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA with mismatched nucleotide incorporation Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:23892398 PMID:22258607, PMID:22918414, PMID:20478261 PMID:22976800, PMID:22475811, PMID:22237395 References_end</body> </html> </notes> <label text="Mismatched_nucleotide*"/> <bbox w="175.0" h="26.0" x="3631.4604" y="6580.988"/> </glyph> <glyph class="nucleic acid feature" id="s1691_sa19" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BER:B-glyc:DNA:st1 DNA with oxidized or ring-saturated base or hydrolysed base Damage caused by ROS* or X-rays Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:23892398, PMID:22258607, PMID:22918414 PMID:23545420 References_end</body> </html> </notes> <label text="Oxidized_ring-saturated_hydrolysed_base*"/> <bbox w="318.0" h="30.0" x="1678.6428" y="6484.8"/> </glyph> <glyph class="nucleic acid feature" id="s3426_sa1616" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:23892398 References_end</body> </html> </notes> <label text="Pyrimidine_dimer*"/> <bbox w="236.0" h="25.0" x="1125.7689" y="6432.0"/> </glyph> <glyph class="nucleic acid feature" id="s1690_sa39" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ligated and repaired DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR Maps_Modules_end</body> </html> </notes> <label text="Repaired_DNA*"/> <bbox w="144.0" h="26.0" x="4683.769" y="8224.999"/> </glyph> <glyph class="nucleic acid feature" id="s1730_sa292" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SSA:DNA:st1 DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:22258607, PMID:22918414, PMID:23897299, PMID:23892398 References_end</body> </html> </notes> <label text="SSA_DNA_st1*"/> <bbox w="120.0" h="26.0" x="4677.351" y="6582.988"/> </glyph> <glyph class="nucleic acid feature" id="s1731_sa293" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SSA:DNA:st2 resected DNA with double strand break Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end</body> </html> </notes> <label text="SSA_DNA_st2*"/> <bbox w="120.0" h="26.0" x="4677.351" y="6756.2373"/> </glyph> <glyph class="nucleic acid feature" id="s1732_sa294" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SSA:DNA:st3 DNA with RAD52 filaments Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end</body> </html> </notes> <label text="SSA_DNA_st3*"/> <bbox w="120.0" h="26.0" x="4677.351" y="7042.7676"/> </glyph> <glyph class="nucleic acid feature" id="s1733_sa295" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SSA:DNA:st4 Annealed DNA with branched un-annealed DNA ends Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end</body> </html> </notes> <label text="SSA_DNA_st4*"/> <bbox w="120.0" h="26.0" x="4677.351" y="7403.299"/> </glyph> <glyph class="nucleic acid feature" id="s1734_sa296" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SSA:DNA:st5 Annealed DNA with trimmed branched un-annealed DNA ends Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end</body> </html> </notes> <label text="SSA_DNA_st5*"/> <bbox w="120.0" h="26.0" x="4677.351" y="7680.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3158_sa1442" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SSA:DNA:st6 Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end</body> </html> </notes> <label text="SSA_DNA_st6*"/> <bbox w="120.0" h="26.0" x="4683.351" y="7859.7227"/> </glyph> <glyph class="nucleic acid feature" id="s3023_sa6" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ShP:BER:M-glyc:st4:B-glyc:DNA:st4 Short patch BER:singe nucleotide replacement pathway DNA with ssb containing incision in AP site, end processed Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="ShP_BER_M-glyc_st4_B-glyc_DNA_st4*"/> <bbox w="254.0" h="26.0" x="1694.6428" y="7414.1055"/> </glyph> <glyph class="nucleic acid feature" id="s3024_sa7" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ShP:BER:M-glyc:st5:B-glyc:DNA:st5 Short patch BER:singe nucleotide replacement pathway DNA with ssb containing replaced unligated residue Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="ShP_BER_M-glyc_st5_B-glyc_DNA_st5*"/> <bbox w="254.0" h="26.0" x="1694.6428" y="7754.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3155_sa1437" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ShP:BER:M-glyc:st4:B-glyc:DNA:st6 Short patch BER: singe nucleotide replacement pathway Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="ShP_BER_M-glyc_st5_B-glyc_DNA_st6*"/> <bbox w="254.0" h="26.0" x="1694.6428" y="7969.333"/> </glyph> <glyph class="nucleic acid feature" id="s3421_sa1611" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: Node_Type:Generic PMID:23892398 References_end</body> </html> </notes> <label text="Single_strand_breaks_SSB*"/> <bbox w="238.0" h="27.0" x="2433.769" y="6287.0"/> </glyph> <glyph class="nucleic acid feature" id="s3425_sa1615" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: Node_Type:Generic PMID:23892398 References_end</body> </html> </notes> <label text="Stalled_replication_fork*"/> <bbox w="242.0" h="23.0" x="4691.769" y="6170.0"/> </glyph> <glyph class="nucleic acid feature" id="s3430_sa1620" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:DNA st1 Transcriptionaly-active chemically or structurally damaged DNA coupled to transcription machinery Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:23892398 PMID:20211143 PMID:22258607, PMID:22918414 PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 UV light causes bulky adducts damage in DNA that repared by NER pathway PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527 Transcription-dependent NER and damage by UV PMID:20045328, PMID:14599741 Interstrand crosslinking agents induce NER PMID:21701511 References_end</body> </html> </notes> <label text="TC-NER_DNA_st1*"/> <bbox w="170.0" h="26.0" x="136.0" y="6449.731"/> </glyph> <glyph class="nucleic acid feature" id="s1682_sa34" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:DNA st2 Transcriptionaly-active chemically or structurally damaged DNA dissociated to transcription machinery Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: Transcription-dependent NER and damage by UV PMID:20045328, PMID:14599741 References_end</body> </html> </notes> <label text="TC-NER_DNA_st2*"/> <bbox w="170.0" h="26.0" x="98.76929" y="6924.8"/> </glyph> <glyph class="nucleic acid feature" id="s1686_sa33" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:GG-NER:DNA:st3 Unwined DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="TC-NER_GG-NER_DNA_st3*"/> <bbox w="170.0" h="26.0" x="594.656" y="7200.1733"/> </glyph> <glyph class="nucleic acid feature" id="s1687_sa269" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:GG-NER:DNA:st4 DNA with 3' and 5' incisions Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:FANCONI Maps_Modules_end References_begin: NER as part of reprication fork resolution PMID:23637285 References_end</body> </html> </notes> <label text="TC-NER_GG-NER_DNA_st4*"/> <bbox w="170.0" h="26.0" x="594.656" y="7522.189"/> </glyph> <glyph class="nucleic acid feature" id="s1689_sa270" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:GG-NER:DNA:st5 DNA with newly synthesized un-ligated DNA fragment Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="TC-NER_GG-NER_DNA_st5*"/> <bbox w="170.0" h="26.0" x="594.656" y="7830.9883"/> </glyph> <glyph class="nucleic acid feature" id="s3154_sa1434" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:GG-NER:DNA:st6 Repaired ligated DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="TC-NER_GG-NER_DNA_st6*"/> <bbox w="170.0" h="26.0" x="594.656" y="7988.5"/> </glyph> <glyph class="nucleic acid feature" id="s3162_sa1446" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TLS:DNA:st1 DNA with AP site or ICL or intrastrand crosslinks. These lesions resulting in stalled replication fork, resolved by TLS during DNA replication. Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:22258607, PMID:22918414, PMID:21701511, PMID:23637285, PMID:23892398 UV double strand damage is repaired by TLS (ICL or intrastrand crosslinks) PMID:22521143 For activation of TLS by cross-linking agents PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263 References_end</body> </html> </notes> <label text="TLS_DNA_st1*"/> <bbox w="120.0" h="26.0" x="9312.768" y="6422.0"/> </glyph> <glyph class="nucleic acid feature" id="s3163_sa1447" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TLS:DNA:st2 Repaired DNA Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: For actovation of TLS by cross-linking agents PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263 References_end</body> </html> </notes> <label text="TLS_DNA_st2*"/> <bbox w="120.0" h="26.0" x="9312.768" y="6574.0"/> </glyph> <glyph class="nucleic acid feature" id="s1293_sa248" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 1 HUGO:USP1, HGNC:12607, ENTREZ:7398 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="USP1"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1941.5625"/> </glyph> <glyph class="nucleic acid feature" id="s1539_sa283" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group C HUGO:XPC, HGNC:12816, ENTREZ:7508 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPC"/> <bbox w="70.0" h="25.0" x="7760.2686" y="1423.8125"/> </glyph> <glyph class="simple chemical" id="s3236_sa1497" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cisplatin CAS:15663-27-1, PUBCHEM:301178, KEGGDRUG:D00275 Mitomicyn C CAS:50-07-7, PUBCHEM:5746, KEGGDRUG:D00208 Oxaliplatin 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</glyph> <glyph class="complex" id="s2318_csa208" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="APC1*/APC2*/APC3*/APC4*/APC5*/APC6*/APC7*/APC8*/APC9*/APC10*/APC11*/APC12"/> <bbox w="259.0" h="197.0" x="3324.4722" y="1073.3562"/> <glyph class="macromolecule" id="s2330_sa938"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end 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HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="3331.4722" y="1205.3562"/> </glyph> <glyph class="macromolecule" id="s2322_sa942"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="3415.4722" y="1078.3562"/> </glyph> <glyph class="macromolecule" id="s2323_sa943"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="3415.4722" y="1120.3562"/> </glyph> <glyph class="macromolecule" id="s2324_sa944"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="3414.4722" y="1163.3562"/> </glyph> <glyph class="macromolecule" id="s2325_sa946"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="3413.4722" y="1205.3562"/> </glyph> <glyph class="macromolecule" id="s2326_sa947"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="3495.4722" y="1205.3562"/> </glyph> <glyph class="macromolecule" id="s2327_sa948"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="3495.4722" y="1165.3562"/> </glyph> <glyph class="macromolecule" id="s2328_sa951"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="3497.4722" y="1121.3562"/> </glyph> </glyph> <glyph class="complex" id="s2472_csa207" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:BUB1:BUB3:BUBR1*:CDC20:MAD1*:MAD2* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="APC1*/APC2*/APC3*/APC4*/APC5*/APC6*/APC7*/APC8*/APC9*/APC10*/APC11*/APC12/BUB1/BUB3/BUBR1*/CDC20/MAD1/MAD2"/> <bbox w="285.0" h="338.0" x="4261.472" y="4483.3564"/> <glyph class="macromolecule" id="s2285_sa926"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991, UNIPROT:Q12834 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="80.0" h="40.0" x="4492.7666" y="4942.922"/> <glyph class="state variable" id="_6f0b908d-da76-4fa6-9a64-b70f9a5513f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4487.7666" y="4957.922"/> </glyph> </glyph> <glyph class="macromolecule" id="s2287_sa928"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD2 mitotic arrest deficient-like 1 (yeast) HUGO:MAD2L1, HGNC:6763, ENTREZ:4085, UNIPROT:13257 MAD2 mitotic arrest deficient-like 2 (yeast) HUGO:MAD2L2, HGNC:6764, ENTREZ:10459, UNIPROT:Q9UI95 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:8824189, PMID:17498870, PMID:15024386, PMID:18022367 References_end</body> </html> </notes> <label text="MAD2*"/> <bbox w="80.0" h="40.0" x="4448.472" y="4533.3564"/> </glyph> <glyph class="macromolecule" id="s2444_sa1092"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 3 homolog (yeast) HUGO:BUB3, HGNC:1151, ENTREZ:9184, UNIPROT:O43684 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with BUB1 and BUBR1* PMID:19182530, PMID:11535616 References_end</body> </html> </notes> <label text="BUB3"/> <bbox w="80.0" h="40.0" x="4366.213" y="4490.056"/> </glyph> <glyph class="macromolecule" id="s2445_sa1093"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog beta (yeast) HUGO:BUB1B, HGNC:1149, ENTREZ:701, UNIPROT:Q59HH6 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3 PMID:17376779, PMID:10477750, PMID:19503101, PMID:11535616, PMID:15592459 As a part of MCC complex, act as pseudo-substrate of APC complex PMID:19154723 References_end</body> </html> </notes> <label text="BUBR1*"/> <bbox w="80.0" h="40.0" x="4364.213" y="4533.056"/> </glyph> <glyph class="macromolecule" id="s2455_sa1099"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAD1 mitotic arrest deficient-like 1 (yeast) HUGO:MAD1L1, HGNC:6762, ENTREZ:8379, UNIPROT:Q9Y6D9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Interacts with CPC complex PMID:11402067, PMID:12640463 References_end</body> </html> </notes> <label text="MAD1*"/> <bbox w="80.0" h="40.0" x="4283.9453" y="4534.252"/> <glyph class="state variable" id="_c708ca43-15fa-4b9a-be84-9f5f7689534a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4286.832" y="4529.252"/> </glyph> </glyph> <glyph class="macromolecule" id="s2457_sa1101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: budding uninhibited by benzimidazoles 1 homolog (yeast) HUGO:BUB1, HGNC:1148, ENTREZ:699, UNIPROT:O43683 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:9790499 References_end</body> </html> </notes> <label text="BUB1"/> <bbox w="80.0" h="40.0" x="4282.9453" y="4490.252"/> <glyph class="state variable" id="_a6e872eb-89b3-4348-8757-ad0aa7749a0a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4288.9976" y="4485.252"/> </glyph> </glyph> <glyph class="macromolecule" id="s2285_sa1160"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991, UNIPROT:Q12834 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="80.0" h="40.0" x="4446.491" y="4574.6396"/> <glyph class="state variable" id="_1a999d79-0eaf-44e3-ad90-548391178011"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4441.491" y="4589.6396"/> </glyph> </glyph> <glyph class="macromolecule" id="s2676_sa1195"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="4282.8965" y="4662.615"/> </glyph> <glyph class="macromolecule" id="s2680_sa1196"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC1, HGNC:19988, ENTREZ:64682, UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="4283.9824" y="4618.9937"/> </glyph> <glyph class="macromolecule" id="s2679_sa1197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 homolog (S. cerevisiae) HUGO:CDC27, HGNC:1728, ENTREZ:996, UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="4280.8965" y="4701.615"/> </glyph> <glyph class="macromolecule" id="s2670_sa1198"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="4279.8965" y="4742.615"/> </glyph> <glyph class="macromolecule" id="s2675_sa1199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="4367.8965" y="4618.615"/> </glyph> <glyph class="macromolecule" id="s2677_sa1200"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="4363.8965" y="4660.615"/> </glyph> <glyph class="macromolecule" id="s2671_sa1201"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="4365.8965" y="4701.615"/> </glyph> <glyph class="macromolecule" id="s2672_sa1202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="4363.8965" y="4743.615"/> </glyph> <glyph class="macromolecule" id="s2673_sa1203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="4445.8965" y="4742.615"/> </glyph> <glyph class="macromolecule" id="s2683_sa1204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="4446.8965" y="4702.615"/> </glyph> <glyph class="macromolecule" id="s2682_sa1205"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="4446.8965" y="4661.615"/> </glyph> </glyph> <glyph class="complex" id="s3310_csa112" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:CDC20 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="APC1*/APC2*/APC3*/APC4*/APC5*/APC6*/APC7*/APC8*/APC9*/APC10*/APC11*/APC12/CDC20"/> <bbox w="278.0" h="214.0" x="3736.4722" y="1063.3562"/> <glyph class="macromolecule" id="s83_sa772"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991, UNIPROT:Q12834 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="80.0" h="40.0" x="3930.4944" y="1071.9775"/> <glyph class="state variable" id="_42957b65-a9c4-41e5-9b73-a2dd6b59a6a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3925.4944" y="1086.9775"/> </glyph> </glyph> <glyph class="macromolecule" id="s3311_sa977"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="3750.4944" y="1115.8467"/> </glyph> <glyph class="macromolecule" id="s3312_sa978"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC1, HGNC:19988, ENTREZ:64682, UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="3752.4944" y="1073.3372"/> </glyph> <glyph class="macromolecule" id="s3313_sa979"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 homolog (S. cerevisiae) HUGO:CDC27, HGNC:1728, ENTREZ:996, UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="3752.4944" y="1159.3372"/> </glyph> <glyph class="macromolecule" id="s3314_sa980"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="3753.4944" y="1204.3372"/> </glyph> <glyph class="macromolecule" id="s3315_sa981"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="3841.08" y="1073.3372"/> </glyph> <glyph class="macromolecule" id="s3316_sa982"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="3839.08" y="1115.8467"/> </glyph> <glyph class="macromolecule" id="s3317_sa983"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="3839.08" y="1159.3372"/> </glyph> <glyph class="macromolecule" id="s3318_sa984"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="3839.08" y="1204.3372"/> </glyph> <glyph class="macromolecule" id="s3319_sa985"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="3925.4944" y="1204.3372"/> </glyph> <glyph class="macromolecule" id="s3320_sa986"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="3925.4944" y="1159.3372"/> </glyph> <glyph class="macromolecule" id="s3321_sa987"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="3925.4944" y="1115.8467"/> </glyph> </glyph> <glyph class="complex" id="s2372_csa114" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:CDC20:CyclinA1* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="APC1*/APC2*/APC3*/APC4*/APC5*/APC6*/APC7*/APC8*/APC9*/APC10*/APC11*/APC12/CDC20"/> <bbox w="278.0" h="215.0" x="4157.472" y="1064.3562"/> <glyph class="macromolecule" id="s91_sa776"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 homolog (S. cerevisiae) HUGO:CDC20, HGNC:1723, ENTREZ:991, UNIPROT:Q12834 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC20"/> <bbox w="80.0" h="40.0" x="4347.472" y="1074.3562"/> <glyph class="state variable" id="_54b4a9a2-fe6c-4a3d-8fb9-b80cb06e9c7a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4339.972" y="1089.3562"/> </glyph> </glyph> <glyph class="macromolecule" id="s2091_sa909"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin A1 HUGO:CCNA1, HGNC:1577, ENTREZ:8900, UNIPROT:P78396 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinA1*"/> <bbox w="80.0" h="40.0" x="4266.1367" y="1171.439"/> </glyph> <glyph class="macromolecule" id="s2622_sa989"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="4176.9946" y="1117.8372"/> </glyph> <glyph class="macromolecule" id="s2631_sa990"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC1, HGNC:19988, ENTREZ:64682, UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="4178.0806" y="1075.2158"/> </glyph> <glyph class="macromolecule" id="s2625_sa991"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 homolog (S. cerevisiae) HUGO:CDC27, HGNC:1728, ENTREZ:996, UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="4176.9946" y="1161.8372"/> </glyph> <glyph class="macromolecule" id="s2628_sa992"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="4177.9946" y="1201.8372"/> </glyph> <glyph class="macromolecule" id="s2620_sa993"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="4261.9946" y="1074.8372"/> </glyph> <glyph class="macromolecule" id="s2623_sa994"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="4261.9946" y="1116.8372"/> </glyph> <glyph class="macromolecule" id="s2626_sa995"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="4260.9946" y="1159.8372"/> </glyph> <glyph class="macromolecule" id="s2629_sa996"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="4259.9946" y="1201.8372"/> </glyph> <glyph class="macromolecule" id="s2630_sa997"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="4341.9946" y="1201.8372"/> </glyph> <glyph class="macromolecule" id="s2627_sa998"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="4341.9946" y="1161.8372"/> </glyph> <glyph class="macromolecule" id="s2624_sa999"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="4343.9946" y="1117.8372"/> </glyph> </glyph> <glyph class="complex" id="s3323_csa111" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:E-Cadherin* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="APC1*/APC2*/APC3*/APC4*/APC5*/APC6*/APC7*/APC8*/APC9*/APC10*/APC11*/APC12/CDH1"/> <bbox w="267.0" h="240.0" x="3745.4722" y="1514.3562"/> <glyph class="macromolecule" id="s86_sa770"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cadherin 1, type 1, E-cadherin (epithelial) HUGO:CDH1, HGNC:1748, ENTREZ:999, UNIPROT:P12830 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="80.0" h="40.0" x="3756.2222" y="1518.3562"/> <glyph class="state variable" id="_13aa352b-9fb1-4d31-952e-2b0ea94238c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3751.2222" y="1533.3562"/> </glyph> </glyph> <glyph class="macromolecule" id="s3324_sa965"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="3756.2222" y="1603.3562"/> </glyph> <glyph class="macromolecule" id="s3325_sa966"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC1, HGNC:19988, ENTREZ:64682, UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="3756.2222" y="1560.735"/> </glyph> <glyph class="macromolecule" id="s3326_sa967"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 homolog (S. cerevisiae) HUGO:CDC27, HGNC:1728, ENTREZ:996, UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="3756.2222" y="1649.3562"/> </glyph> <glyph class="macromolecule" id="s3327_sa968"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="3756.2222" y="1689.3562"/> </glyph> <glyph class="macromolecule" id="s3328_sa969"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="3839.4722" y="1560.3562"/> </glyph> <glyph class="macromolecule" id="s3329_sa970"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="3839.4722" y="1604.3562"/> </glyph> <glyph class="macromolecule" id="s3330_sa971"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="3839.4722" y="1647.3562"/> </glyph> <glyph class="macromolecule" id="s3331_sa972"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="3839.4722" y="1689.3562"/> </glyph> <glyph class="macromolecule" id="s3332_sa973"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="3922.4722" y="1689.3562"/> </glyph> <glyph class="macromolecule" id="s3333_sa974"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="3924.4722" y="1648.3562"/> </glyph> <glyph class="macromolecule" id="s3334_sa975"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="3924.4722" y="1605.3562"/> </glyph> </glyph> <glyph class="complex" id="s2386_csa113" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:E-Cadherin* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="APC1*/APC2*/APC3*/APC4*/APC5*/APC6*/APC7*/APC8*/APC9*/APC10*/APC11*/APC12/CDH1"/> <bbox w="259.0" h="238.0" x="4184.472" y="1516.3562"/> <glyph class="macromolecule" id="s94_sa774"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cadherin 1, type 1, E-cadherin (epithelial) HUGO:CDH1, HGNC:1748, ENTREZ:999, UNIPROT:P12830 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="80.0" h="40.0" x="4190.9946" y="1519.3562"/> <glyph class="state variable" id="_c4b6869e-e1b1-47e2-823e-b4a5afdda0ac"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4183.4946" y="1534.3562"/> </glyph> </glyph> <glyph class="macromolecule" id="s2636_sa1001"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="4190.9946" y="1603.8372"/> </glyph> <glyph class="macromolecule" id="s2643_sa1002"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC1, HGNC:19988, ENTREZ:64682, UNIPROT:Q9H1A4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="4190.9946" y="1561.2158"/> </glyph> <glyph class="macromolecule" id="s2639_sa1003"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 homolog (S. cerevisiae) HUGO:CDC27, HGNC:1728, ENTREZ:996, UNIPROT:P30260 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="4190.9946" y="1647.8372"/> </glyph> <glyph class="macromolecule" id="s2642_sa1004"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4, HGNC:19990, ENTREZ:29945, UNIPROT:Q9UJX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="4190.9946" y="1687.8372"/> </glyph> <glyph class="macromolecule" id="s2635_sa1005"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5, HGNC:15713, ENTREZ:51433, UNIPROT:Q9UJX4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="4274.9946" y="1560.8372"/> </glyph> <glyph class="macromolecule" id="s2637_sa1006"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 homolog (S. cerevisiae) HUGO:CDC16, HGNC:1720, ENTREZ:8881, UNIPROT:Q13042 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="4274.9946" y="1602.8372"/> </glyph> <glyph class="macromolecule" id="s2640_sa1007"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7, HGNC:17380, ENTREZ:51434, UNIPROT:Q9UJX3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="4274.9946" y="1645.8372"/> </glyph> <glyph class="macromolecule" id="s2633_sa1008"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 homolog (S. cerevisiae) HUGO:CDC23, HGNC:1724, ENTREZ:8697, UNIPROT:Q9UJX2 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="4274.9946" y="1687.8372"/> </glyph> <glyph class="macromolecule" id="s2634_sa1009"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 homolog (S. cerevisiae) HUGO:CDC26, HGNC:17839, ENTREZ:246184, UNIPROT:Q8NHZ8 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="4355.9946" y="1687.8372"/> </glyph> <glyph class="macromolecule" id="s2641_sa1010"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 HUGO:ANAPC11, HGNC:14452, ENTREZ:51529, UNIPROT:Q9NYG5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="4355.9946" y="1645.1704"/> </glyph> <glyph class="macromolecule" id="s2638_sa1011"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10, HGNC:24077, ENTREZ:10393, UNIPROT:Q9UM13 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:M_CC_PHASE MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="4355.9946" y="1602.5038"/> </glyph> </glyph> <glyph class="complex" id="s3178_csa25" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APE*:Mg2+:PCNA:WRN Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:19748837, PMID:12637553, PMID:10858306, PMID:11948190, PMID:16442856, PMID:15385537, PMID:17116323 References_end</body> </html> </notes> <label text="APE*/PCNA/WRN/Mg2+"/> <bbox w="140.0" h="210.0" x="2020.4722" y="7236.3564"/> <glyph class="simple chemical" id="s176_sa486"> <label text="Mg2+"/> <bbox w="35.0" h="31.0" x="2067.9722" y="7292.8564"/> </glyph> <glyph class="macromolecule" id="s517_sa487"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: APEX nuclease (multifunctional DNA repair enzyme) 1 HUGO:APEX1, ENTREZ:328, UNIPROT:P27695 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 HUGO:APEX2, ENTREZ:27301, UNIPROT:Q9UBZ4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: Apyrimidinic endonucleases, APE PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362 For Phosphorylation by CK2 PMID:20955519, PMID:9407949 Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death PMID:23110144, PMID:22455312 CDK5 and MDM2 activate APE for shift to BER activity PMID:21727086, PMID:21922195 References_end</body> </html> </notes> <label text="APE*"/> <bbox w="80.0" h="40.0" x="2048.9722" y="7333.8564"/> <glyph class="state variable" id="_09adb4b0-59ef-4ee1-b403-9f19a0c65442"> <state value="P" variable="Thr233"/> <bbox w="45.0" h="10.0" x="2075.7654" y="7328.8564"/> </glyph> <glyph class="state variable" id="_8b704989-4260-450a-b6d6-86fa72b81aac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2043.9722" y="7342.775"/> </glyph> <glyph class="state variable" id="_afa605dc-d857-4aba-b170-62e44f4da038"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="2118.9722" y="7343.124"/> </glyph> </glyph> <glyph class="macromolecule" id="s1652_sa488"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="2049.9722" y="7381.7847"/> <glyph class="state variable" id="_c7e50f9a-9de6-4ff8-b893-3257356f3ed9"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="2038.956" y="7376.7847"/> </glyph> <glyph class="state variable" id="_351488d9-1da7-4e5e-982a-06ec227a1edc"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="2034.9722" y="7396.7847"/> </glyph> <glyph class="state variable" id="_ba53ec38-8a79-4c39-87a6-48cb973dd7eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2068.4036" y="7416.7847"/> </glyph> <glyph class="state variable" id="_15c3d26a-bb4a-431e-a553-f5f2c92a5605"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2044.9722" y="7416.7847"/> </glyph> <glyph class="state variable" id="_2874b084-4475-4cb5-9bf6-6926c5aaef63"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2084.9722" y="7416.7847"/> </glyph> </glyph> <glyph class="macromolecule" id="s3177_sa1459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="2048.2222" y="7255.1064"/> <glyph class="state variable" id="_b794e9b8-90d8-4c37-a1a5-ead911bacc19"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2081.97" y="7250.1064"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3413_csa35" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATM:CTIP*:MRE11*:NBS1*:RAD50:WRN Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 Activation of WRN in cancers PMID:18524993 http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 References_end</body> </html> </notes> <label text="ATM/CtIP*/MRE11*/NBS*/RAD50/WRN"/> <bbox w="196.0" h="161.0" x="6431.472" y="6778.3564"/> <glyph class="macromolecule" id="s978_sa530"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="6538.222" y="6836.3564"/> <glyph class="state variable" id="_367d3eae-95ce-4e3e-934c-74d8dd6777cc"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="6546.8174" y="6831.3564"/> </glyph> <glyph class="state variable" id="_41f5b225-78df-4cbd-b55b-470aaa3e63f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6533.222" y="6851.3564"/> </glyph> <glyph class="state variable" id="_3f0720d0-0610-4e17-bfa1-f33be76a5704"> <state value="" variable="S267"/> <bbox w="30.0" h="10.0" x="6523.222" y="6861.728"/> </glyph> <glyph class="state variable" id="_45ea11fe-b106-4e09-b758-eba1a0967997"> <state value="" variable="T847"/> <bbox w="30.0" h="10.0" x="6523.222" y="6838.2075"/> </glyph> <glyph class="state variable" id="_284e5c1a-c92f-47e7-944c-658b1f240fad"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="6542.091" y="6871.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s1523_sa532"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A, HGNC:7230, ENTREZ:4361, UNIPROT:P49959 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) HUGO:RE11B, HGNC:7231, ENTREZ:4362 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="6534.972" y="6790.3564"/> </glyph> <glyph class="macromolecule" id="s983_sa533"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="6447.972" y="6879.3564"/> </glyph> <glyph class="macromolecule" id="s3221_sa534"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="6444.222" y="6837.8564"/> <glyph class="state variable" id="_3c39bb03-5f0e-45ca-a42f-5d0905228244"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="6426.722" y="6861.0405"/> </glyph> </glyph> <glyph class="macromolecule" id="s3047_sa1405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: DDR by ATM PMID:23847781 PMID:17303408, PMID:16163361, PMID:15964794 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:11877377 References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="6442.2124" y="6790.5894"/> <glyph class="state variable" id="_51c4cf6d-0aee-4ecb-bf90-91c3b35cf1c7"> <state value="P" variable="S367"/> <bbox w="35.0" h="10.0" x="6438.8604" y="6785.5894"/> </glyph> <glyph class="state variable" id="_38587609-0c09-4dac-af52-df302a1f41c4"> <state value="P" variable="S1981"/> <bbox w="40.0" h="10.0" x="6422.2124" y="6805.5576"/> </glyph> <glyph class="state variable" id="_41145d8c-de60-4064-a1e1-75a81cc644b4"> <state value="P" variable="S1893"/> <bbox w="40.0" h="10.0" x="6422.2124" y="6821.1196"/> </glyph> </glyph> <glyph class="macromolecule" id="s3412_sa1604"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="6538.0107" y="6878.2793"/> <glyph class="state variable" id="_efdc5f1d-9816-4a28-a51a-2af0fc7ad2b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6571.7583" y="6873.2793"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s72_csa34" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATM:H2AFX:MDC1:MRE11*:NBS1*:RAD50 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17303408, PMID:16531125 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="ATM/H2AX*/MDC1/MRE11*/NBS*/RAD50"/> <bbox w="281.0" h="115.0" x="5847.472" y="4400.3564"/> <glyph class="macromolecule" id="s1521_sa524"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A, HGNC:7230, ENTREZ:4361, UNIPROT:P49959 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) HUGO:RE11B, HGNC:7231, ENTREZ:4362 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="6040.222" y="4409.3564"/> </glyph> <glyph class="macromolecule" id="s3214_sa526"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1, HGNC:21163, ENTREZ:9656, UNIPROT:Q2TAZ4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:C_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890 References_end</body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="5863.1323" y="4452.7227"/> <glyph class="state variable" id="_9bf6cb1e-e14a-4717-8a15-9d47df75615d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5855.6323" y="4467.691"/> </glyph> </glyph> <glyph class="macromolecule" id="s806_sa527"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="5953.222" y="4454.3564"/> </glyph> <glyph class="macromolecule" id="s3215_sa529"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="6041.722" y="4452.4487"/> <glyph class="state variable" id="_1c9f2fd3-5c17-492b-9ce0-d08e5b3baf6c"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="6024.222" y="4475.633"/> </glyph> </glyph> <glyph class="macromolecule" id="s3044_sa1402"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="5861.776" y="4408.6665"/> <glyph class="state variable" id="_9981e677-33a2-4079-84d3-69142d749600"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5851.776" y="4406.599"/> </glyph> <glyph class="state variable" id="_37d2f87b-be2e-4abd-bc35-7559368ccf79"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="5844.276" y="4423.6665"/> </glyph> </glyph> <glyph class="macromolecule" id="s3046_sa1404"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: DDR by ATM PMID:23847781 PMID:17303408, PMID:16163361, PMID:15964794 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:11877377 References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="5952.7124" y="4408.7964"/> <glyph class="state variable" id="_630f5c7b-6ee0-48e6-818d-ce7266130118"> <state value="P" variable="S367"/> <bbox w="35.0" h="10.0" x="5949.3604" y="4403.7964"/> </glyph> <glyph class="state variable" id="_c10ce2ef-b141-4d03-ad60-c6743625b91f"> <state value="P" variable="S1981"/> <bbox w="40.0" h="10.0" x="5932.7124" y="4423.7646"/> </glyph> <glyph class="state variable" id="_dedde3c1-182e-4655-9815-4a8983b4dd21"> <state value="P" variable="S1893"/> <bbox w="40.0" h="10.0" x="5932.7124" y="4439.3267"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s63_csa33" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATM:MRE11*:NBS1*:RAD50 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17303408, PMID:16163361, PMID:15964794 References_end</body> </html> </notes> <label text="ATM/MRE11*/NBS*/RAD50"/> <bbox w="187.0" h="117.0" x="6999.472" y="5515.3564"/> <glyph class="macromolecule" id="s807_sa520"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: DDR by ATM PMID:23847781 PMID:17303408, PMID:16163361, PMID:15964794 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:11877377 References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="7012.6895" y="5529.4077"/> <glyph class="state variable" id="_0f5d0a4c-75ce-4a86-85f8-43625713f4e4"> <state value="P" variable="S367"/> <bbox w="35.0" h="10.0" x="7009.3374" y="5524.4077"/> </glyph> <glyph class="state variable" id="_ec8a6250-ceac-452e-b19b-b11a8491658d"> <state value="P" variable="S1981"/> <bbox w="40.0" h="10.0" x="6992.6895" y="5544.376"/> </glyph> <glyph class="state variable" id="_5f736920-2f46-4ef4-b91c-df82893ab45b"> <state value="P" variable="S1893"/> <bbox w="40.0" h="10.0" x="6992.6895" y="5559.938"/> </glyph> </glyph> <glyph class="macromolecule" id="s2871_sa521"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A, HGNC:7230, ENTREZ:4361, UNIPROT:P49959 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) HUGO:RE11B, HGNC:7231, ENTREZ:4362 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="7094.722" y="5529.8564"/> </glyph> <glyph class="macromolecule" id="s2869_sa522"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="7095.722" y="5571.8564"/> </glyph> <glyph class="macromolecule" id="s3217_sa1485"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="7011.0557" y="5573.023"/> <glyph class="state variable" id="_02e36e2f-82cf-4de2-9031-99c904c9b840"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="6993.5557" y="5596.207"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1414_csa87" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATM:SNM1B* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end</body> </html> </notes> <label text="ATM/SNM1B*"/> <bbox w="100.0" h="120.0" x="5127.472" y="3834.3562"/> <glyph class="macromolecule" id="s1415_sa710"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1B, HGNC:17641, ENTREZ:64858, UNIPROT:Q9H816 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20655466, PMID:18469862 References_end</body> </html> </notes> <label text="SNM1B*"/> <bbox w="80.0" h="40.0" x="5136.472" y="3893.3562"/> </glyph> <glyph class="macromolecule" id="s3045_sa1403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated HUGO:ATM, HGNC:795, ENTREZ:472, UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: DDR by ATM PMID:23847781 PMID:17303408, PMID:16163361, PMID:15964794 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:11877377 References_end</body> </html> </notes> <label text="ATM"/> <bbox w="80.0" h="40.0" x="5138.3364" y="3845.1118"/> <glyph class="state variable" id="_09a01686-0a45-4a85-8d83-9a7abdc7f4f1"> <state value="P" variable="S367"/> <bbox w="35.0" h="10.0" x="5134.9844" y="3840.1118"/> </glyph> <glyph class="state variable" id="_f95a5a21-45da-46f7-8506-1f516350f6d2"> <state value="P" variable="S1981"/> <bbox w="40.0" h="10.0" x="5118.3364" y="3860.08"/> </glyph> <glyph class="state variable" id="_4393c7d2-1721-477a-b69a-159b4ce0de7c"> <state value="P" variable="S1893"/> <bbox w="40.0" h="10.0" x="5118.3364" y="3875.642"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1673_csa101" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:ATRIP Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15743907 ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair: PMID:16713580 References_end</body> </html> </notes> <label text="ATR/ATRIP"/> <bbox w="100.0" h="120.0" x="5020.472" y="2708.3562"/> <glyph class="macromolecule" id="s1675_sa746"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5034.472" y="2765.642"/> <glyph class="state variable" id="_6d8ead77-0eeb-4721-ad14-d01268d9526f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5026.972" y="2780.642"/> </glyph> </glyph> <glyph class="macromolecule" id="s1674_sa747"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5031.472" y="2723.642"/> </glyph> </glyph> <glyph class="complex" id="s2945_csa253" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:ATRIP:CHEK1:CLSPN:HCLK2* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:17384638, PMID:19793801 References_end</body> </html> </notes> <label text="ATR/ATRIP/CHEK1/CLSPN/HCLK2*"/> <bbox w="193.0" h="161.0" x="5703.472" y="4014.3562"/> <glyph class="macromolecule" id="s2949_sa1331"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TEL2, telomere maintenance 2, homolog (S. cerevisiae) Protein clk-2 homolog , HCLK2 HUGO:TELO2, HGNC:29099, ENTREZ:9894, UNIPROT:Q9Y4R8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 For regulation of Fanconi pathway via cell cycle PMID:18995830, PMID:17384638 For S-phase checkpoint PMID:17384638, PMID:19793801 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 References_end</body> </html> </notes> <label text="HCLK2*"/> <bbox w="80.0" h="40.0" x="5717.9663" y="4024.1262"/> </glyph> <glyph class="macromolecule" id="s2948_sa1332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5720.9663" y="4108.4116"/> <glyph class="state variable" id="_9a6f9d07-07f4-4464-bbfb-061046ff3cb1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5713.4663" y="4123.4116"/> </glyph> </glyph> <glyph class="macromolecule" id="s2947_sa1333"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5717.9663" y="4066.4119"/> </glyph> <glyph class="macromolecule" id="s2950_sa1336"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111, UNIPROT:O14757 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <bbox w="80.0" h="40.0" x="5805.226" y="4068.1262"/> <glyph class="state variable" id="_00cbe424-3ecf-4946-8615-694c1bef0cd5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5797.726" y="4083.1262"/> </glyph> </glyph> <glyph class="macromolecule" id="s2983_sa1362"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="5799.932" y="4023.3906"/> <glyph class="state variable" id="_5011d0cb-8f49-4e4a-83fa-3760480195da"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5872.432" y="4030.1064"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2969_csa258" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:ATRIP:CHEK1:CLSPN:PCNA:TIM1* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105 References_end</body> </html> </notes> <label text="ATR/ATRIP/CHEK1/PCNA/TIM1*"/> <bbox w="272.0" h="118.0" x="5848.472" y="4251.3564"/> <glyph class="macromolecule" id="s2974_sa1350"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="6029.005" y="4259.8354"/> <glyph class="state variable" id="_08523cea-799b-4602-b1b8-f3ed23efddf5"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="6017.989" y="4254.8354"/> </glyph> <glyph class="state variable" id="_012c3c16-77af-4097-8e3f-d8e8f54a99c2"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="6009.005" y="4274.8354"/> </glyph> <glyph class="state variable" id="_4d8bad11-dbbb-4beb-80d3-1119f3c41a02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6047.4365" y="4294.8354"/> </glyph> <glyph class="state variable" id="_64e2d6bd-5987-40b9-9bbd-2dd70f555e30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6024.005" y="4294.8354"/> </glyph> <glyph class="state variable" id="_efb4dda8-7a17-4ee4-8b02-a5dc1dcf6d2f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6064.005" y="4294.8354"/> </glyph> </glyph> <glyph class="macromolecule" id="s2972_sa1351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: timeless homolog (Drosophila) HUGO:TIMELESS, HGNC:11813, ENTREZ:8914, UNIPROT:Q9UNS1 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725, PMID:15798197 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIM1*"/> <bbox w="80.0" h="40.0" x="5941.4277" y="4302.4214"/> </glyph> <glyph class="macromolecule" id="s2971_sa1352"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5858.4277" y="4302.707"/> <glyph class="state variable" id="_28e4b163-6673-4800-a874-83ee78ff92b1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5850.9277" y="4317.707"/> </glyph> </glyph> <glyph class="macromolecule" id="s2973_sa1353"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5854.4277" y="4256.707"/> </glyph> <glyph class="macromolecule" id="s2970_sa1354"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111, UNIPROT:O14757 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <bbox w="80.0" h="40.0" x="5939.4277" y="4258.4214"/> <glyph class="state variable" id="_66efe797-f8bb-46cd-b063-c7503a5c248d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5931.9277" y="4273.4214"/> </glyph> </glyph> <glyph class="macromolecule" id="s2984_sa1363"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="6022.932" y="4301.3906"/> <glyph class="state variable" id="_6f88fc58-8c7f-4ea7-8cd9-0a73ca3ac29c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6095.432" y="4308.1064"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2985_csa260" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:ATRIP:CHEK1:CLSPN:RPA1:RPA2:RPA3:TIM1*:TIPIN Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: Stalled replication forks or double strand breaks in the S-phase re-orient activity of TIM1*/TIPIN from the DNA replication to DNA repair. TIM1*/TIPIN as part of this complex inhibits teplication and stablises stalled replication forks till DNA damage is repaired PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATR/ATRIP/CLSPN/CHEK1/RPA1/RPA2/RPA3/TIM1*/TIPIN"/> <bbox w="335.0" h="160.0" x="5303.472" y="3825.3562"/> <glyph class="macromolecule" id="s2990_sa1341"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111, UNIPROT:O14757 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <bbox w="80.0" h="40.0" x="5514.395" y="3920.5173"/> <glyph class="state variable" id="_c14a5578-6626-4aab-bd30-0633200e4af6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5506.895" y="3935.5173"/> </glyph> </glyph> <glyph class="macromolecule" id="s2992_sa1364"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: timeless homolog (Drosophila) HUGO:TIMELESS, HGNC:11813, ENTREZ:8914, UNIPROT:Q9UNS1 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725, PMID:15798197 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIM1*"/> <bbox w="80.0" h="40.0" x="5345.521" y="3834.8826"/> </glyph> <glyph class="macromolecule" id="s2993_sa1365"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TIMELESS interacting protein HUGO:TIPIN, HGNC:30750, ENTREZ:54962, UNIPROT:Q9BVW5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIPIN"/> <bbox w="80.0" h="40.0" x="5425.521" y="3835.8826"/> </glyph> <glyph class="macromolecule" id="s2994_sa1366"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="5506.646" y="3834.9563"/> <glyph class="state variable" id="_2514e73e-0c05-4919-84f7-f6bfc42b1deb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5579.146" y="3841.672"/> </glyph> </glyph> <glyph class="macromolecule" id="s2989_sa1367"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="5348.514" y="3878.4658"/> </glyph> <glyph class="macromolecule" id="s2988_sa1368"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="5427.514" y="3875.4658"/> <glyph class="state variable" id="_de4449f8-71f8-43ef-841f-1c16c0175cb6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5422.514" y="3890.4658"/> </glyph> </glyph> <glyph class="macromolecule" id="s2987_sa1369"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="5505.514" y="3875.4658"/> </glyph> <glyph class="macromolecule" id="s2986_sa1370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5351.5835" y="3918.6743"/> </glyph> <glyph class="macromolecule" id="s2991_sa1371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5434.5835" y="3918.6743"/> <glyph class="state variable" id="_0ab8132b-18a1-4fa9-aaf7-d878f5772586"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5427.0835" y="3933.6743"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2921_csa249" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:ATRIP:CLSPN:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:17303408 References_end</body> </html> </notes> <label text="ATR/ATRIP/CLSPN/RPA1/RPA2/RPA3"/> <bbox w="191.0" h="161.0" x="5520.472" y="3444.3562"/> <glyph class="macromolecule" id="s2926_sa1308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="5532.5225" y="3451.2756"/> </glyph> <glyph class="macromolecule" id="s2925_sa1309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="5530.5225" y="3493.2756"/> <glyph class="state variable" id="_e172426b-fdeb-48f2-996f-22c5b89f2dce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5525.5225" y="3508.2756"/> </glyph> </glyph> <glyph class="macromolecule" id="s2922_sa1310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="5530.5225" y="3535.2756"/> </glyph> <glyph class="macromolecule" id="s2923_sa1312"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5616.156" y="3493.2668"/> </glyph> <glyph class="macromolecule" id="s2924_sa1313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5616.156" y="3535.2668"/> <glyph class="state variable" id="_7663b57d-d3be-4ded-bdc5-646452405da2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5608.656" y="3550.2668"/> </glyph> </glyph> <glyph class="macromolecule" id="s2981_sa1360"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="5613.1426" y="3451.357"/> <glyph class="state variable" id="_21b54f59-72ad-4b33-b7e4-73ca1d4c77fd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5685.6426" y="3458.0728"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1935_csa123" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:ATRIP:CLSPN:RAD17:TOPBP1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="ATR/ATRIP/TOPBP1"/> <bbox w="112.0" h="236.0" x="5533.472" y="3138.3562"/> <glyph class="macromolecule" id="s1937_sa796"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: topoisomerase (DNA) II binding protein 1 HUGO:TOPBP1, HGNC:17008, ENTREZ:11073, UNIPROT:Q92547 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:17303408, PMID:16530042 References_end</body> </html> </notes> <label text="TOPBP1"/> <bbox w="80.0" h="40.0" x="5550.7734" y="3225.9124"/> </glyph> <glyph class="macromolecule" id="s1936_sa797"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATR interacting protein HUGO:ATRIP, HGNC:33499, ENTREZ:84126, UNIPROT:Q9HA30 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:15798197, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="ATRIP"/> <bbox w="80.0" h="40.0" x="5548.7734" y="3269.4124"/> </glyph> <glyph class="macromolecule" id="s1939_sa798"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5549.7734" y="3311.0923"/> <glyph class="state variable" id="_f43187fe-a9fd-4f04-9ca2-ce063c3cfd5d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5542.2734" y="3326.0923"/> </glyph> </glyph> <glyph class="macromolecule" id="s1944_sa800"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD17 homolog (S. pombe) HUGO:RAD17, HGNC:9807, ENTREZ:5884, UNIPROT:O75943 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:16885023, PMID:17303408 References_end</body> </html> </notes> <label text="RAD17"/> <bbox w="80.0" h="40.0" x="5548.847" y="3145.2622"/> <glyph class="state variable" id="_8efd306f-4324-44a7-b2ef-33c944d57e61"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5541.347" y="3160.2622"/> </glyph> </glyph> <glyph class="macromolecule" id="s2980_sa1359"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Claspin HUGO:CLSPN, HGNC:19715, ENTREZ:63967, UNIPROT:Q9HAW4 PMID:17303408, PMID:16880517, PMID:16934469 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152 References_end</body> </html> </notes> <label text="CLSPN"/> <bbox w="80.0" h="40.0" x="5550.8926" y="3185.357"/> <glyph class="state variable" id="_bd18e901-9638-4409-ad4d-fbdfc8af3848"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5623.3926" y="3192.0728"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1309_csa78" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:FAAP24*:FANCM:HCLK2* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 References_end</body> </html> </notes> <label text="ATR/FAAP24*/FANCM/HCLK2*"/> <bbox w="183.0" h="132.0" x="5712.472" y="3826.3562"/> <glyph class="macromolecule" id="s1310_sa690"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TEL2, telomere maintenance 2, homolog (S. cerevisiae) Protein clk-2 homolog , HCLK2 HUGO:TELO2, HGNC:29099, ENTREZ:9894, UNIPROT:Q9Y4R8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 For regulation of Fanconi pathway via cell cycle PMID:18995830, PMID:17384638 For S-phase checkpoint PMID:17384638, PMID:19793801 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 References_end</body> </html> </notes> <label text="HCLK2*"/> <bbox w="80.0" h="40.0" x="5721.329" y="3836.785"/> </glyph> <glyph class="macromolecule" id="s1311_sa691"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 19 open reading frame 40, "Fanconi anemia-associated protein, 24 kDa" HUGO:C19orf40, HGNC:28467, ENTREZ:91442, UNIPROT:Q9BTP7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP24*"/> <bbox w="80.0" h="40.0" x="5804.329" y="3836.785"/> </glyph> <glyph class="macromolecule" id="s1312_sa692"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group M HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:NER MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 Link between Fanconi and NER PMID:22615860 Fanconi and cross-linking agents PMID:21948210 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCM"/> <bbox w="80.0" h="40.0" x="5806.329" y="3886.785"/> <glyph class="state variable" id="_e37544ee-f301-477b-a20e-df03697bb55b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5841.329" y="3881.785"/> </glyph> </glyph> <glyph class="macromolecule" id="s1313_sa693"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5725.615" y="3885.0706"/> <glyph class="state variable" id="_35beef25-81dd-476b-b96d-99b80a130e45"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5718.115" y="3900.0706"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1371_csa68" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATR:FANCD2:MRE11*:NBS1*:RAD50 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS Maps_Modules_end References_begin: PMID:15136767 References_end</body> </html> </notes> <label text="ATR/FANCD2/MRE11*/NBS*/RAD50A"/> <bbox w="200.0" h="178.0" x="5407.472" y="4239.3564"/> <glyph class="macromolecule" id="s1376_sa662"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia and Rad3 related HUGO:ATR, HGNC:882, ENTREZ:545, UNIPROT:Q13535 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase PMID:19282663, PMID:19622404 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="ATR"/> <bbox w="80.0" h="40.0" x="5518.472" y="4250.3564"/> <glyph class="state variable" id="_480c0acb-7991-4ec1-b969-c88e0bc240da"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5510.972" y="4265.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s1377_sa663"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="5518.222" y="4304.3564"/> <glyph class="state variable" id="_a3f86247-6aa2-4677-9f94-07aab578b878"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5510.722" y="4311.0723"/> </glyph> <glyph class="state variable" id="_bc09580c-f28a-4287-b418-984fc46b501b"> <state value="Ub" variable="K561"/> <bbox w="40.0" h="10.0" x="5538.1265" y="4339.3564"/> </glyph> <glyph class="state variable" id="_b63f335a-4c2b-4d34-a160-0c9319dddbfc"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="5544.054" y="4299.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2867_sa664"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A, HGNC:7230, ENTREZ:4361, UNIPROT:P49959 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) HUGO:RE11B, HGNC:7231, ENTREZ:4362 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="5416.615" y="4247.7134"/> </glyph> <glyph class="macromolecule" id="s2865_sa665"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="5416.615" y="4287.7134"/> </glyph> <glyph class="macromolecule" id="s3220_sa666"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="5420.222" y="4335.8564"/> <glyph class="state variable" id="_da60f44c-b8ef-4e67-ba68-53a9a80a2e39"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="5402.722" y="4359.0405"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2585_csa233" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AURKA:BRCA1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="AURCA/BRCA1"/> <bbox w="113.0" h="120.0" x="8137.472" y="6802.3564"/> <glyph class="macromolecule" id="s2587_sa1183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="8153.557" y="6814.5444"/> <glyph class="state variable" id="_9ece344d-0086-40a4-8c79-4c076fc316d4"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="8216.057" y="6814.7837"/> </glyph> <glyph class="state variable" id="_a29179c7-872a-4b8d-ac72-8f9bd31395a8"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="8193.419" y="6809.5444"/> </glyph> <glyph class="state variable" id="_801b5dd5-ab18-4baa-acc9-b6521c12c813"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="8173.3086" y="6809.5444"/> </glyph> <glyph class="state variable" id="_959f04c4-86aa-426a-8b4b-b319ee85519a"> <state value="" variable="S1423"/> <bbox w="35.0" h="10.0" x="8155.184" y="6809.5444"/> </glyph> <glyph class="state variable" id="_49f151f8-16e9-40c2-88c1-b8fd66922c26"> <state value="P" variable="S308"/> <bbox w="35.0" h="10.0" x="8136.057" y="6845.0156"/> </glyph> <glyph class="state variable" id="_47d2e6b5-bfef-4625-8d98-fd88ed7ea76a"> <state value="" variable="S1524"/> <bbox w="35.0" h="10.0" x="8136.057" y="6829.5127"/> </glyph> <glyph class="state variable" id="_850d77d2-96a7-4098-a7d8-5dc4b25ca157"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8225.643" y="6849.5444"/> </glyph> </glyph> <glyph class="macromolecule" id="s2586_sa1184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: aurora kinase A HUGO:AURKA, HGNC:11393, ENTREZ:6790, UNIPROT:O14965 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: AURKA phosphorylates and activates CDC25B on Ser339 to allow G2/M transition PMID:19075565, PMID:20011137 References_end</body> </html> </notes> <label text="AURKA"/> <bbox w="80.0" h="40.0" x="8154.807" y="6859.5444"/> </glyph> </glyph> <glyph class="complex" id="s2413_csa216" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AURKB:BIRC5:Borealin*:INCENP Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="AURCB/Borealin*/INCENP/Survivin*"/> <bbox w="191.0" h="115.0" x="3964.4722" y="4744.3564"/> <glyph class="macromolecule" id="s2415_sa1052"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: aurora kinase B HUGO:AURKB, HGNC:11390, ENTREZ:9212, UNIPROT:Q96GD4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:14767480 Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="AURKB"/> <bbox w="80.0" h="40.0" x="3976.7827" y="4754.0146"/> <glyph class="state variable" id="_4b5b7b92-e294-4313-9b5b-0fa980357aec"> <state value="P" variable="T232"/> <bbox w="35.0" h="10.0" x="3959.2827" y="4769.0146"/> </glyph> </glyph> <glyph class="macromolecule" id="s2416_sa1053"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle associated 8, Borealin HUGO:CDCA8, HGNC:14629, ENTREZ:55143, UNIPROT:Q53HL2 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="Borealin*"/> <bbox w="80.0" h="40.0" x="4068.7827" y="4753.9526"/> <glyph class="state variable" id="_7923da88-a288-428c-bf27-cddd1d57834c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4061.2827" y="4768.9526"/> </glyph> </glyph> <glyph class="macromolecule" id="s2414_sa1054"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: baculoviral IAP repeat-containing 5, Surverin HUGO:BIRC5, HGNC:593, ENTREZ:332, UNIPROT:Q9P2W8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="BIRC5"/> <bbox w="80.0" h="40.0" x="3976.7827" y="4796.9526"/> </glyph> <glyph class="macromolecule" id="s2418_sa1056"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inner centromere protein antigens 135/155kDa HUGO:INCENP, HGNC:6058, ENTREZ:3619, UNIPROT:Q9NQS7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Component of the chromosomal passenger complex (CPC) PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674 References_end</body> </html> </notes> <label text="INCENP"/> <bbox w="80.0" h="40.0" x="4068.7827" y="4793.928"/> <glyph class="state variable" id="_5f2b0fdc-74aa-4b4a-ba9e-3f3cd41aea48"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4061.2827" y="4808.928"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3407_csa31" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APLF:Artemis*:DNA-PK*:Ku70*:Ku80*:LIG4:PARP3:XLF*:XRCC4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PARP1 and PARP3 in C_NHEJ PMID:22469522 APLF and PARP3 PMID:21211721‎ PMID:23178593 PMID:18077224‎ References_end</body> </html> </notes> <label text="Artemis*/APLF/DNA-PK*/Ku70*/Ku80*/LIG4/PARP3/XLF/XRCC4"/> <bbox w="307.0" h="189.0" x="5555.472" y="7680.3564"/> <glyph class="macromolecule" id="s2765_sa510"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="5562.472" y="7689.8564"/> </glyph> <glyph class="macromolecule" id="s2764_sa511"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <bbox w="80.0" h="40.0" x="5561.472" y="7736.8564"/> <glyph class="state variable" id="_3f9789fa-40cb-4c55-a8eb-2e374a053d72"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5579.904" y="7731.8564"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="s914_sa512"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="5744.722" y="7737.3564"/> <glyph class="unit of information" id="_21174384-59db-4fa8-aa3a-5ccd16df79a6"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5774.722" y="7732.3564"/> </glyph> <glyph class="state variable" id="_e33b7051-ce78-4348-9060-aceb161f1d79"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5739.722" y="7752.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s918_sa513"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1C, HGNC:17642, ENTREZ:64421, UNIPROT:Q5JSS7 Identifiers_end 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</glyph> </glyph> <glyph class="macromolecule" id="s2760_sa514"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ligase IV, DNA, ATP-dependent HUGO:LIG4, HGNC:6601, ENTREZ:3981, UNIPROT:P49917 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:12471202, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="LIG4"/> <bbox w="80.0" h="40.0" x="5649.472" y="7734.8564"/> </glyph> <glyph class="macromolecule" id="s2761_sa515"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XLF 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PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="XRCC4"/> <bbox w="80.0" h="40.0" x="5741.472" y="7690.8564"/> <glyph class="unit of information" id="_86a9301d-5b51-4d97-8d3e-995105740536"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5771.472" y="7685.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s3369_sa1582"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 3 HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 PARP3 in chromatin remodeling PMID:22469522, PMID:22713970 APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ PARP3 in C_NHEJ PMID:22743550 References_end</body> </html> </notes> <label text="PARP3"/> <bbox w="80.0" h="40.0" x="5648.329" y="7689.0703"/> </glyph> <glyph class="macromolecule" id="s3406_sa1600"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: aprataxin and PNKP like factor HUGO:APLF HGNC:28724 ENTREZ:200558 UNIPROT:Q8IW19 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ References_end</body> </html> </notes> <label text="APLF"/> <bbox w="80.0" h="40.0" x="5564.597" y="7784.3564"/> </glyph> </glyph> <glyph class="complex" id="s3409_csa29" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Artemis*:DNA-PK*:Ku70*:Ku80*:PARP3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: The complex presents in double amount to cover both ends of broken DNA double helix PMID:18558713 PARP3 and PARP1 in C_NHEJ PMID:22469522, PMID:196269035 References_end</body> </html> </notes> <label text="Artemis*/DNA-PK*/Ku70*/Ku80*/PARP1/PARP3"/> <bbox w="264.0" h="125.0" x="5535.472" y="7384.3564"/> <glyph class="macromolecule multimer" id="s913_sa496"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="5541.222" y="7395.3564"/> <glyph class="unit of information" id="_cd43d1dc-b813-4cc3-9080-11d304cf47c5"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5571.222" y="7390.3564"/> </glyph> <glyph class="state variable" id="_aebbd884-dd37-4c8e-8f4c-d1f03119590f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5536.222" y="7410.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s917_sa497"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1C, HGNC:17642, ENTREZ:64421, UNIPROT:Q5JSS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495 References_end</body> </html> </notes> <label text="Artemis*"/> <bbox w="80.0" h="40.0" x="5704.8057" y="7400.1895"/> <glyph class="state variable" id="_dfcd2d0b-529d-44c8-a1b8-97b2c3fe4cc1"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="5710.901" y="7395.1895"/> </glyph> <glyph class="state variable" id="_facc6e16-16ce-4e7f-99b7-a7125cfb1e47"> <state value="P" variable="S645"/> <bbox w="35.0" h="10.0" x="5687.7983" y="7395.1895"/> </glyph> <glyph class="state variable" 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binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="5619.472" y="7392.8564"/> </glyph> <glyph class="macromolecule" id="s2757_sa499"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <bbox w="80.0" h="40.0" x="5619.472" y="7437.8564"/> <glyph class="state variable" id="_d06cfd59-9726-4b89-a6aa-69b2b71a0cdf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5637.904" y="7432.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s3367_sa1580"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 3 HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 PARP3 in chromatin remodeling PMID:22469522, PMID:22713970 APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ PARP3 in C_NHEJ PMID:22743550 References_end</body> </html> </notes> <label text="PARP3"/> <bbox w="80.0" h="40.0" x="5539.1865" y="7444.6895"/> </glyph> </glyph> <glyph class="complex" id="s1029_csa59" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BARD1:BRCA1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="BARD1/BRCA1"/> <bbox w="93.0" h="105.0" x="7553.472" y="7034.3564"/> <glyph class="macromolecule" id="s1028_sa629"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 associated RING domain 1 HUGO:BARD1, HGNC:952, ENTREZ:580, UNIPROT:Q99728 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="BARD1"/> <bbox w="80.0" h="40.0" x="7557.472" y="7037.3564"/> </glyph> <glyph class="macromolecule" id="s1030_sa630"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7558.7803" y="7077.626"/> <glyph class="state variable" id="_2ea84481-269c-49b7-858e-629b00e2fb13"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7621.2803" y="7077.865"/> </glyph> <glyph class="state variable" id="_58ec7d42-9347-4244-a78a-a999cfb333fe"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="7598.642" y="7072.626"/> </glyph> <glyph class="state variable" id="_deb4ac88-13ec-4168-ab0a-b7d2b326ae65"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="7578.5317" y="7072.626"/> </glyph> <glyph class="state variable" id="_1dc78d5e-237b-4dd0-9de3-79e2dd150bf5"> <state value="" variable="S1423"/> <bbox w="35.0" h="10.0" x="7560.407" y="7072.626"/> </glyph> <glyph class="state variable" id="_acf8382a-ed92-4d02-8e76-4650354eb31c"> <state value="" variable="S308"/> <bbox w="30.0" h="10.0" x="7543.7803" 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For Fancony anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="FANCN*"/> <bbox w="80.0" h="40.0" x="6989.112" y="6990.249"/> </glyph> <glyph class="macromolecule" id="s1378_sa502"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7070.722" y="6948.8564"/> <glyph class="state variable" id="_3c28a49c-59fa-49fa-9dfb-fdeac696849e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7063.222" y="6955.5723"/> </glyph> <glyph class="state variable" id="_abd1f503-2dd8-4c41-bcf3-69c70fcaccd3"> <state value="Ub" variable="K561"/> <bbox w="40.0" h="10.0" x="7090.6265" y="6983.8564"/> </glyph> <glyph class="state variable" id="_e7ce56bc-9515-41fa-9f82-cdb14eab52d8"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="7096.554" y="6943.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2863_sa503"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 associated RING domain 1 HUGO:BARD1, HGNC:952, ENTREZ:580, UNIPROT:Q99728 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="BARD1"/> <bbox w="80.0" h="40.0" x="6981.649" y="6866.202"/> </glyph> <glyph class="macromolecule" id="s2862_sa504"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="6982.957" y="6906.472"/> <glyph class="state variable" id="_a5430af2-1557-4c7f-a170-c5897549a296"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7045.457" y="6906.7114"/> </glyph> <glyph class="state variable" id="_1e037e57-6b95-4767-a12c-062bfb2d8e7b"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="7022.819" y="6901.472"/> </glyph> <glyph class="state variable" id="_6c806b79-b2ec-4bfa-853b-2ab85e93866b"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="7002.7085" y="6901.472"/> </glyph> <glyph class="state variable" id="_0d4d9ec9-e813-4fb7-a61e-1913d617bd76"> <state value="" variable="S1423"/> <bbox w="35.0" h="10.0" x="6984.584" y="6901.472"/> </glyph> <glyph class="state variable" id="_6ac298c3-88dd-47a7-b22a-d3b613658d90"> <state value="" variable="S308"/> <bbox w="30.0" h="10.0" x="6967.957" y="6936.9434"/> </glyph> <glyph class="state variable" id="_181d51cb-5ab7-4f03-9a19-e24a853bfe42"> <state value="" variable="S1524"/> <bbox w="35.0" h="10.0" x="6965.457" y="6921.4404"/> </glyph> <glyph class="state variable" id="_7cf81d28-c7d7-4dc0-8c59-9e38d882d2d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7055.043" y="6941.472"/> </glyph> </glyph> <glyph class="macromolecule" id="s2860_sa505"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7072.826" y="6867.491"/> </glyph> <glyph class="macromolecule" id="s2859_sa506"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: split hand/foot malformation (ectrodactyly) type 1 HUGO:SHFM1, HGNC:10845 ENTREZ:7979, UNIPROT:P60896 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="DSS1*"/> <bbox w="80.0" h="40.0" x="7071.826" y="6907.491"/> </glyph> <glyph class="macromolecule" id="s2857_sa507"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51A HUGO:RAD51, HGNC:9817, ENTREZ:5888, UNIPROT:Q06609 RAD51-like 1 (S. cerevisiae), RAD51B HUGO:RAD51L1, HGNC:9822, ENTREZ:5890, UNIPROT:Q86U92 RAD51 homolog C (S. cerevisiae) HUGO:RAD51C, HGNC:9820, ENTREZ:5889, UNIPROT:O43502 RAD51-like 3 (S. cerevisiae), RAD51D HUGO:RAD51L3, HGNC:9823, ENTREZ:5892, UNIPROT:O94908 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="80.0" h="40.0" x="7162.9185" y="6866.5474"/> </glyph> <glyph class="macromolecule" id="s2855_sa508"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 2 HUGO:XRCC2, HGNC:12829, ENTREZ:7516, UNIPROT:O43543 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC2"/> <bbox w="80.0" h="40.0" x="7157.9185" y="6906.5474"/> </glyph> <glyph class="macromolecule" id="s2856_sa509"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 3 HUGO:XRCC3, HGNC:12830, ENTREZ:7517, UNIPROT:O43542 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC3"/> <bbox w="80.0" h="40.0" x="7154.9185" y="6946.5474"/> </glyph> <glyph class="macromolecule" id="s3061_sa1415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCT-repeat inhibitor of TERT expression 1 (BRIT1), Microcephalin(MCPH1) HUGO:MCPH1, HGNC:6954, ENTREZ:79648, UNIPROT:Q8NEM0 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:20376879, PMID:15220350, PMID:19525936, PMID:18660752 References_end</body> </html> </notes> <label text="BRIT1*"/> <bbox w="80.0" h="40.0" x="7074.472" y="6991.3564"/> </glyph> <glyph class="macromolecule" id="s3146_sa1429"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Splicing factor proline/glutamine-rich (SFPQ), Polypyrimidine tract binding protein associated (PSF) HUGO:SFPQ, HGNC:10774, ENTREZ:6421, UNIPROT:P23246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:20813759, PMID:10931916, PMID:15590677, PMID:19759212, PMID:10858305 References_end</body> </html> </notes> <label text="SFPQ"/> <bbox w="80.0" h="40.0" x="7160.752" y="6988.3037"/> </glyph> </glyph> <glyph class="complex" id="s1023_csa52" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BLM:EXO1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="BLM/EXO1"/> <bbox w="100.0" h="120.0" x="7094.472" y="5982.3564"/> <glyph class="macromolecule" id="s1024_sa596"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Bloom syndrome, RecQ helicase-like HUGO:BLM, HGNC:1058, ENTREZ:641, UNIPROT:P54132 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: For HR pathway, PMID:22657828 PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 BLM in telomere maintenance PMID:23253856 Resolving stalled replication fork BLM inhibits A_NHEJ (alt_NHEJ): PMID:24089143 PMID:24095737 References_end</body> </html> </notes> <label text="BLM"/> <bbox w="80.0" h="40.0" x="7107.7515" y="6037.513"/> </glyph> <glyph class="macromolecule" id="s1025_sa597"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: exonuclease 1 HUGO:EXO1, HGNC:3511, ENTREZ:9156, UNIPROT:Q9UQ84 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:14676842, PMID:15474417, PMID:18756267, PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:19490890, PMID:11438669, PMID:20019063, PMID:18048416 References_end</body> </html> </notes> <label text="EXO1"/> <bbox w="80.0" h="40.0" x="7105.7515" y="5993.513"/> <glyph class="state variable" id="_f9443921-b76d-4929-96d0-ea167302d854"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="7090.7515" y="6024.782"/> </glyph> <glyph class="state variable" id="_a4952b2f-9556-41bd-9d71-64c362094740"> <state value="" variable="S692"/> <bbox w="30.0" h="10.0" x="7147.7007" y="5988.513"/> </glyph> <glyph class="state variable" id="_76593755-0c99-46d5-891a-7b34ddb1616e"> <state value="" variable="S587"/> <bbox w="30.0" h="10.0" x="7090.7515" y="6006.5063"/> </glyph> <glyph class="state variable" id="_131cd83f-d3fb-42db-964a-2a799979d8af"> <state value="" variable="S567"/> <bbox w="30.0" h="10.0" x="7090.7515" y="5992.519"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3241_csa3" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BLM:FAAP100*:FAAP20*:FAAP24*:FANCA:FANCB:FANCC:FANCE:FANCF:FANCG:FANCL:FANCM:HES1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: The complex has two functions, FANCM and BLM create reverse-fork structure creating four way junction and allowing initiation of repair for FA core complex and the following steps evolving NER and HR proteins. FANCL ubiquitinates FANCD2 that together with FANCI initiates the repair PMID:19622404 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="BLM/FAAP20*/FAAP24*/FAAP100*/FANCA/FANCB/FANCC/FANCE/FANCF/FANCG/FANCL/FANCM/HES1"/> <bbox w="360.0" h="198.0" x="8443.473" y="7708.3564"/> <glyph class="macromolecule" id="s1401_sa372"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Bloom syndrome, RecQ helicase-like HUGO:BLM, HGNC:1058, ENTREZ:641, UNIPROT:P54132 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: For HR pathway, PMID:22657828 PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 BLM in telomere maintenance PMID:23253856 Resolving stalled replication fork BLM inhibits A_NHEJ (alt_NHEJ): PMID:24089143 PMID:24095737 References_end</body> </html> </notes> <label text="BLM"/> <bbox w="80.0" h="40.0" x="8715.973" y="7718.8564"/> </glyph> <glyph class="macromolecule" id="s1405_sa373"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hairy and enhancer of split 1, (Drosophila) HUGO:HES1, HGNC:5192, ENTREZ:3280, UNIPROT:Q14469 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:8020957, PMID:12535671, PMID:12972610, PMID:18550849, PMID:20832754 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="HES1"/> <bbox w="80.0" h="40.0" x="8714.187" y="7762.3564"/> </glyph> <glyph class="macromolecule" id="s2827_sa374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group C HUGO:FANCC, HGNC:3584, ENTREZ:2176, UNIPROT:Q00597 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCC"/> <bbox w="80.0" h="40.0" x="8546.836" y="7793.981"/> </glyph> <glyph class="macromolecule" id="s2826_sa375"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group F HUGO:FANCF, HGNC:3587, ENTREZ:2188, UNIPROT:Q9NPI8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCF"/> <bbox w="80.0" h="40.0" x="8712.836" y="7842.981"/> </glyph> <glyph class="macromolecule" id="s2825_sa376"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group E HUGO:FANCE, HGNC:3586, ENTREZ:2178, UNIPROT:Q9HB96 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCE"/> <bbox w="80.0" h="40.0" x="8544.139" y="7839.416"/> <glyph class="state variable" id="_5afa8b21-4e15-43f4-9207-5d9e5ac939ba"> <state value="P" variable="T346"/> <bbox w="35.0" h="10.0" x="8526.639" y="7854.3843"/> </glyph> <glyph class="state variable" id="_514d4343-a169-4a19-96d7-bb246318a423"> <state value="P" variable="S376"/> <bbox w="35.0" h="10.0" x="8526.639" y="7845.9224"/> </glyph> </glyph> <glyph class="macromolecule" id="s2823_sa377"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group B HUGO:FANCB, HGNC:3583, ENTREZ:2187, UNIPROT:Q8NB91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCB"/> <bbox w="80.0" h="40.0" x="8627.836" y="7801.2046"/> </glyph> <glyph class="macromolecule" id="s2821_sa378"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group L HUGO:FANCL, HGNC:20748, ENTREZ:55120, UNIPROT:Q9NW38 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: The enzyme possesses E3 ubiquitin ligase activity, the active part in the Fanconi core complex PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCL"/> <bbox w="80.0" h="40.0" x="8628.836" y="7843.2046"/> </glyph> <glyph class="macromolecule" id="s2822_sa379"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: some 17 open reading frame 70, FAAP100 HUGO:C17orf70, HGNC:26171, ENTREZ:80233, UNIPROT:Q0VG06 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP100*"/> <bbox w="80.0" h="40.0" x="8713.836" y="7802.2046"/> </glyph> <glyph class="macromolecule" id="s2833_sa380"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 19 open reading frame 40, "Fanconi anemia-associated protein, 24 kDa" HUGO:C19orf40, HGNC:28467, ENTREZ:91442, UNIPROT:Q9BTP7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP24*"/> <bbox w="80.0" h="40.0" x="8628.3125" y="7714.6846"/> </glyph> <glyph class="macromolecule" id="s2832_sa381"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group M HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:NER MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 Link between Fanconi and NER PMID:22615860 Fanconi and cross-linking agents PMID:21948210 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCM"/> <bbox w="80.0" h="40.0" x="8628.3125" y="7757.6846"/> <glyph class="state variable" id="_230b2d3a-ba05-497e-a29e-52a74588e236"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8663.3125" y="7752.6846"/> </glyph> </glyph> <glyph class="macromolecule" id="s2830_sa382"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group A HUGO:FANCA, HGNC:3582, ENTREZ:2175, UNIPROT:Q9UEL9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCA"/> <bbox w="80.0" h="40.0" x="8539.912" y="7712.8496"/> <glyph class="state variable" id="_0cda7809-c5ea-4aa0-b218-cc811b52805d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8612.412" y="7727.8496"/> </glyph> </glyph> <glyph class="macromolecule" id="s2829_sa383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group G HUGO:FANCG, HGNC:3588, UNIPROT:O15287 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCG"/> <bbox w="80.0" h="40.0" x="8540.35" y="7754.6064"/> <glyph class="state variable" id="_33204242-6899-4405-ae9e-07f8539deedf"> <state value="P" variable="S7"/> <bbox w="25.0" h="10.0" x="8551.444" y="7749.6064"/> </glyph> </glyph> <glyph class="macromolecule" id="s3239_sa1513"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 1 open reading frame 86 HUGO:C1orf86, HGNC:26428, ENTREZ:199990, UNIPROT:Q6NZ36 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP20*"/> <bbox w="80.0" h="40.0" x="8454.264" y="7715.1064"/> </glyph> </glyph> <glyph class="complex" id="s3242_csa55" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BLM:FAAP100*:FAAP20*:FAAP24*:FANCA:FANCB:FANCC:FANCE:FANCF:FANCG:FANCL:FANCM:HES1:RPA1:RPA2:RPA3:TOP3A Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="BLM/FAAP20*/FAAP24*/FAAP100*/FANCA/FANCB/FANCC/FANCE/FANCF/FANCG/FANCL/FANCM/HES1/RPA1/RPA2/RPA3/TOP3A"/> <bbox w="439.0" h="197.0" x="8416.473" y="8016.3564"/> <glyph class="macromolecule" id="s1321_sa603"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: topoisomerase (DNA) III alpha HUGO:TOP3A, HGNC:11992, ENTREZ:7156, UNIPROT:Q13472 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="TOP3A"/> <bbox w="80.0" h="40.0" x="8760.329" y="8154.499"/> </glyph> <glyph class="macromolecule" id="s2837_sa605"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="8762.16" y="8029.0796"/> </glyph> <glyph class="macromolecule" id="s2835_sa606"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="8762.16" y="8071.0796"/> <glyph class="state variable" id="_428bb9b5-0265-4b1d-bed2-bfa46e6a26ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8757.16" y="8086.0796"/> </glyph> </glyph> <glyph class="macromolecule" id="s2836_sa607"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="8762.16" y="8111.0796"/> </glyph> <glyph class="macromolecule" id="s2839_sa1255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Bloom syndrome, RecQ helicase-like HUGO:BLM, HGNC:1058, ENTREZ:641, UNIPROT:P54132 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: For HR pathway, PMID:22657828 PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 BLM in telomere maintenance PMID:23253856 Resolving stalled replication fork BLM inhibits A_NHEJ (alt_NHEJ): PMID:24089143 PMID:24095737 References_end</body> </html> </notes> <label text="BLM"/> <bbox w="80.0" h="40.0" x="8677.462" y="8029.178"/> </glyph> <glyph class="macromolecule" id="s2840_sa1256"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hairy and enhancer of split 1, (Drosophila) HUGO:HES1, HGNC:5192, ENTREZ:3280, UNIPROT:Q14469 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:8020957, PMID:12535671, PMID:12972610, PMID:18550849, PMID:20832754 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="HES1"/> <bbox w="80.0" h="40.0" x="8675.677" y="8072.678"/> </glyph> <glyph class="macromolecule" id="s2848_sa1257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group C HUGO:FANCC, HGNC:3584, ENTREZ:2176, UNIPROT:Q00597 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCC"/> <bbox w="80.0" h="40.0" x="8503.326" y="8110.3027"/> </glyph> <glyph class="macromolecule" id="s2841_sa1258"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group F HUGO:FANCF, HGNC:3587, ENTREZ:2188, UNIPROT:Q9NPI8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCF"/> <bbox w="80.0" h="40.0" x="8502.326" y="8150.3027"/> </glyph> <glyph class="macromolecule" id="s2849_sa1259"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group E HUGO:FANCE, HGNC:3586, ENTREZ:2178, UNIPROT:Q9HB96 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCE"/> <bbox w="80.0" h="40.0" x="8426.629" y="8070.738"/> <glyph class="state variable" id="_cfe79a58-28da-41df-8741-e6cccfebc958"> <state value="P" variable="T346"/> <bbox w="35.0" h="10.0" x="8409.129" y="8085.706"/> </glyph> <glyph class="state variable" id="_e7d9647c-0366-40a9-9952-e72c84b71a1d"> <state value="P" variable="S376"/> <bbox w="35.0" h="10.0" x="8409.129" y="8077.244"/> </glyph> </glyph> <glyph class="macromolecule" id="s2842_sa1260"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group B HUGO:FANCB, HGNC:3583, ENTREZ:2187, UNIPROT:Q8NB91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCB"/> <bbox w="80.0" h="40.0" x="8586.326" y="8111.5264"/> </glyph> <glyph class="macromolecule" id="s2843_sa1261"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group L HUGO:FANCL, HGNC:20748, ENTREZ:55120, UNIPROT:Q9NW38 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: The enzyme possesses E3 ubiquitin ligase activity, the active part in the Fanconi core complex PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCL"/> <bbox w="80.0" h="40.0" x="8588.326" y="8151.5264"/> </glyph> <glyph class="macromolecule" id="s2844_sa1262"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: some 17 open reading frame 70, FAAP100 HUGO:C17orf70, HGNC:26171, ENTREZ:80233, UNIPROT:Q0VG06 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP100*"/> <bbox w="80.0" h="40.0" x="8675.326" y="8112.5264"/> </glyph> <glyph class="macromolecule" id="s2845_sa1263"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 19 open reading frame 40, "Fanconi anemia-associated protein, 24 kDa" HUGO:C19orf40, HGNC:28467, ENTREZ:91442, UNIPROT:Q9BTP7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP24*"/> <bbox w="80.0" h="40.0" x="8586.803" y="8025.0063"/> </glyph> <glyph class="macromolecule" id="s2846_sa1264"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group M HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:NER MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 Link between Fanconi and NER PMID:22615860 Fanconi and cross-linking agents PMID:21948210 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCM"/> <bbox w="80.0" h="40.0" x="8586.803" y="8068.0063"/> <glyph class="state variable" id="_b97c35a0-4039-4efd-bd72-3b90aaef94c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8621.803" y="8063.0063"/> </glyph> </glyph> <glyph class="macromolecule" id="s2850_sa1265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group A HUGO:FANCA, HGNC:3582, ENTREZ:2175, UNIPROT:Q9UEL9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCA"/> <bbox w="80.0" h="40.0" x="8501.401" y="8025.1714"/> <glyph class="state variable" id="_f7f4a796-80b7-436c-befd-68c9190fde09"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8573.901" y="8040.1714"/> </glyph> </glyph> <glyph class="macromolecule" id="s2847_sa1266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group G HUGO:FANCG, HGNC:3588, UNIPROT:O15287 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCG"/> <bbox w="80.0" h="40.0" x="8501.973" y="8068.0547"/> <glyph class="state variable" id="_fca9885d-e694-4a6c-978f-4472bda6f715"> <state value="P" variable="S7"/> <bbox w="25.0" h="10.0" x="8513.067" y="8063.0547"/> </glyph> </glyph> <glyph class="macromolecule" id="s3240_sa1514"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 1 open reading frame 86 HUGO:C1orf86, HGNC:26428, ENTREZ:199990, UNIPROT:Q6NZ36 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP20*"/> <bbox w="80.0" h="40.0" x="8418.264" y="8026.1064"/> </glyph> </glyph> <glyph class="complex" id="s1449_csa57" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BLM:RMI1:TOP3A Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="BLM/RMI1/TOP3A"/> <bbox w="111.0" h="149.0" x="7167.472" y="8052.3564"/> <glyph class="macromolecule" id="s1062_sa623"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: topoisomerase (DNA) III alpha HUGO:TOP3A, HGNC:11992, ENTREZ:7156, UNIPROT:Q13472 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="TOP3A"/> <bbox w="80.0" h="40.0" x="7176.6235" y="8104.4243"/> </glyph> <glyph class="macromolecule" id="s1061_sa624"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Bloom syndrome, RecQ helicase-like HUGO:BLM, HGNC:1058, ENTREZ:641, UNIPROT:P54132 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: For HR pathway, PMID:22657828 PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 BLM in telomere maintenance PMID:23253856 Resolving stalled replication fork BLM inhibits A_NHEJ (alt_NHEJ): PMID:24089143 PMID:24095737 References_end</body> </html> </notes> <label text="BLM"/> <bbox w="80.0" h="40.0" x="7175.6465" y="8063.4243"/> </glyph> <glyph class="macromolecule" id="s1448_sa625"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) HUGO:RMI1, HGNC:25764, ENTREZ:80010, UNIPROT:Q9H9A7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:16537486, PMID:19945966, PMID:20826342, PMID:16595695 References_end</body> </html> </notes> <label text="RMI1"/> <bbox w="80.0" h="40.0" x="7177.329" y="8142.9277"/> </glyph> </glyph> <glyph class="complex" id="s3300_csa37" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559 References_end</body> </html> </notes> <label text="BRCA1/BRCA2/FANCD2/FANCI/FANCJ*/FANCN*/RPA1/RPA2/RPA3"/> <bbox w="276.0" h="161.0" x="7391.472" y="7357.3564"/> <glyph class="macromolecule" id="s3301_sa537"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7404.615" y="7407.9277"/> </glyph> <glyph class="macromolecule" id="s3302_sa538"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7405.615" y="7364.9277"/> <glyph class="state variable" id="_b9979c36-1ca7-4cac-9942-461cfc0dadec"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7468.115" y="7365.167"/> </glyph> <glyph class="state variable" id="_f5846156-d219-49f8-a39c-2aef6e97c118"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="7445.477" y="7359.9277"/> </glyph> <glyph class="state variable" id="_860fc5df-1e19-46fd-ad88-dc1668bb862e"> <state value="" 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</head> <body>Identifiers_begin: BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ HUGO:BRIP1, HGNC:20473, ENTREZ:83990, UNIPROT:Q9BX63 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:TLS MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism PMID:20173781 References_end</body> </html> </notes> <label text="FANCJ*"/> <bbox w="80.0" h="40.0" x="7492.615" y="7364.9277"/> <glyph class="state variable" id="_bf6b83d7-31d9-4a84-be0c-b421e2945ef8"> <state value="" variable="S990"/> <bbox w="30.0" h="10.0" x="7517.647" y="7359.9277"/> </glyph> </glyph> <glyph class="macromolecule" id="s3304_sa540"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: "Fanconi anemia, complementation group N" HUGO:PALB2, HGNC:26144, ENTREZ:79728, UNIPROT:Q86YC2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:22505525 Parthner and localizer of BRCA2. For Fancony anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="FANCN*"/> <bbox w="80.0" h="40.0" x="7487.615" y="7410.499"/> </glyph> <glyph class="macromolecule" id="s2811_sa541"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="7490.115" y="7452.5703"/> <glyph class="state variable" id="_3dc15c2a-6c6e-4e52-b2cb-ccc28a7e8de5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7562.615" y="7487.5703"/> </glyph> <glyph class="state variable" id="_89682826-9f76-4bd9-812f-4fde53325a5c"> <state value="Ub" variable="K523"/> <bbox w="40.0" h="10.0" x="7508.8193" y="7487.5703"/> </glyph> </glyph> <glyph class="macromolecule" id="s2810_sa542"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7407.9785" y="7453.0"/> <glyph class="state variable" id="_2ba5e560-063f-4e2a-ab8e-b2d2608f6c75"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7400.4785" y="7459.716"/> </glyph> <glyph class="state variable" id="_195d9339-8fde-4378-8c86-dd08bd9793bc"> <state value="Ub" variable="K561"/> <bbox w="40.0" h="10.0" x="7427.883" y="7488.0"/> </glyph> <glyph class="state variable" id="_0b8685a4-8185-4a91-9f6b-58f218ffdbad"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="7433.8105" y="7448.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3305_sa543"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="7576.6416" y="7365.062"/> </glyph> <glyph class="macromolecule" id="s3306_sa544"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="7576.6416" y="7407.062"/> <glyph class="state variable" id="_5c02007a-f767-4999-84b4-884a7c462e98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7571.6416" y="7422.062"/> </glyph> </glyph> <glyph class="macromolecule" id="s3307_sa545"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="7576.6416" y="7447.062"/> </glyph> </glyph> <glyph class="complex" id="s1211_csa38" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559 References_end</body> </html> </notes> <label text="BRCA1/BRCA2/FANCD2/FANCI/FANCJ*/FANCN*/RPA1/RPA2/RPA3"/> <bbox w="295.0" h="161.0" x="7003.472" y="7491.3564"/> <glyph class="macromolecule" id="s1203_sa546"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7016.615" y="7541.9277"/> </glyph> <glyph class="macromolecule" id="s1204_sa547"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7017.615" y="7498.9277"/> <glyph class="state variable" id="_9e9c1929-1c3f-47b1-aed8-425500e5069d"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7080.115" y="7499.167"/> </glyph> <glyph class="state variable" id="_5d5b994c-96b7-4888-9b2a-b8a5d4e83f27"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="7057.477" y="7493.9277"/> </glyph> <glyph class="state 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ HUGO:BRIP1, HGNC:20473, ENTREZ:83990, UNIPROT:Q9BX63 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:TLS MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism PMID:20173781 References_end</body> </html> </notes> <label text="FANCJ*"/> <bbox w="80.0" h="40.0" x="7104.615" y="7498.9277"/> <glyph class="state variable" id="_c424ed78-0005-411f-9f48-ff9afc582a71"> <state value="" variable="S990"/> <bbox w="30.0" h="10.0" x="7129.647" y="7493.9277"/> </glyph> </glyph> <glyph class="macromolecule" id="s1210_sa549"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: "Fanconi anemia, complementation group N" HUGO:PALB2, HGNC:26144, ENTREZ:79728, UNIPROT:Q86YC2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:22505525 Parthner and localizer of BRCA2. For Fancony anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="FANCN*"/> <bbox w="80.0" h="40.0" x="7101.615" y="7545.499"/> </glyph> <glyph class="macromolecule" id="s1618_sa550"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7020.4785" y="7587.5"/> <glyph class="state variable" id="_3f30fc11-4e32-432c-9817-e679791fb72a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7012.9785" y="7594.216"/> </glyph> <glyph class="state variable" id="_70686a72-eaef-49bb-bff4-7f77e1a747ea"> <state value="" variable="K561"/> <bbox w="30.0" h="10.0" x="7045.383" y="7622.5"/> </glyph> <glyph class="state variable" id="_ca93faa4-bfe5-457e-b559-28358de157c5"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="7046.3105" y="7582.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s1617_sa551"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="7101.615" y="7588.0703"/> <glyph class="state variable" id="_49f27857-b2c1-4a95-ba77-f400f6f45591"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7174.115" y="7623.0703"/> </glyph> <glyph class="state variable" id="_27c19ad6-40cc-433b-8744-e585a107dc6a"> <state value="" variable="K523"/> <bbox w="30.0" h="10.0" x="7125.3193" y="7623.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s2814_sa554"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="7189.6416" y="7585.062"/> </glyph> <glyph class="macromolecule" id="s2813_sa553"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="7189.6416" y="7543.062"/> <glyph class="state variable" id="_29f1aafb-617a-4bb7-ae32-7c38ce474fd6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7184.6416" y="7558.062"/> </glyph> </glyph> <glyph class="macromolecule" id="s2815_sa552"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="7190.6416" y="7500.062"/> </glyph> </glyph> <glyph class="complex" id="s3292_csa45" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: The complex participates in the HR and S-checkpoint PMID:12239151, PMID:19686080 For Fanconi PMID:19622404 The complex is considered to be the actual repair structure of the pathway. MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559 References_end</body> </html> </notes> <label text="BRCA1/BRCA2/FANCD2/FANCI/H2AX*/NBS*/PCNA/RAD51/Tip60*"/> <bbox w="362.0" h="160.0" x="6939.472" y="7074.3564"/> <glyph class="macromolecule" id="s3293_sa572"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7036.472" y="7085.3564"/> </glyph> <glyph class="macromolecule" id="s3294_sa573"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7207.329" y="7129.047"/> <glyph class="state variable" id="_9eb2c9ea-fbc2-4b09-b2dc-52c84272d87f"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7269.829" 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x="7279.415" y="7164.047"/> </glyph> </glyph> <glyph class="macromolecule" id="s3295_sa574"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="7127.0435" y="7088.0703"/> <glyph class="state variable" id="_80fb96f9-7b1c-4111-ab4a-f576242b3e89"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="7116.0273" y="7083.0703"/> </glyph> <glyph class="state variable" id="_be168228-33ee-4f18-8ad7-2ff54ca7f641"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="7112.0435" y="7103.0703"/> </glyph> <glyph class="state variable" id="_bbbdad21-30c2-4b32-be00-d5d44dce3235"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7145.475" y="7123.0703"/> </glyph> <glyph class="state variable" id="_bbd99ee8-d389-4f00-bb41-167833482660"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7122.0435" y="7123.0703"/> </glyph> <glyph class="state variable" id="_f321c561-499e-4f57-90c5-fe4c1eaf19b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7162.0435" y="7123.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s3296_sa575"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="7126.579" y="7135.0703"/> <glyph class="state variable" id="_4f092bf2-2063-4fb9-87fb-ff12c0a26471"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7116.579" y="7133.003"/> </glyph> <glyph class="state variable" id="_e7d01683-4e70-4811-87c7-85b7cc89c4ef"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7109.079" y="7150.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s3297_sa576"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51A HUGO:RAD51, HGNC:9817, ENTREZ:5888, UNIPROT:Q06609 RAD51-like 1 (S. cerevisiae), RAD51B HUGO:RAD51L1, HGNC:9822, ENTREZ:5890, UNIPROT:Q86U92 RAD51 homolog C (S. cerevisiae) HUGO:RAD51C, HGNC:9820, ENTREZ:5889, UNIPROT:O43502 RAD51-like 3 (S. cerevisiae), RAD51D HUGO:RAD51L3, HGNC:9823, ENTREZ:5892, UNIPROT:O94908 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="80.0" h="40.0" x="7210.0435" y="7086.9277"/> </glyph> <glyph class="macromolecule" id="s3298_sa577"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="6956.722" y="7172.3564"/> <glyph class="state variable" id="_7e5aa9e6-c90b-45c7-b682-74946ad25aa2"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="6939.222" y="7195.5405"/> </glyph> </glyph> <glyph class="macromolecule" id="s3299_sa578"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: K(lysine) acetyltransferase 5 HUGO:KAT5, HGNC:5275, ENTREZ:10524, UNIPROT:Q92993 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:12551922, PMID:11927554, PMID:21574959, PMID:18085520 References_end</body> </html> </notes> <label text="TIP60*"/> <bbox w="80.0" h="40.0" x="7210.0557" y="7133.1064"/> </glyph> <glyph class="macromolecule" id="s1629_sa579"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="6951.472" y="7131.0703"/> <glyph class="state variable" id="_0c790f5a-a248-4a44-a2b7-ac33e6c94268"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7023.972" y="7166.0703"/> </glyph> <glyph class="state variable" id="_f6013615-3849-435b-b840-57e363822fd4"> <state value="" variable="K523"/> <bbox w="30.0" h="10.0" x="6975.1763" y="7166.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s1628_sa580"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="6953.3354" y="7085.5"/> <glyph class="state variable" id="_75bd3aaa-5dff-4f57-816d-ff1d79498ebe"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6945.8354" y="7092.216"/> </glyph> <glyph class="state variable" id="_9d76f1b5-5a4a-4b12-a40a-c50f1e62ad92"> <state value="" variable="K561"/> <bbox w="30.0" h="10.0" x="6978.2397" y="7120.5"/> </glyph> <glyph class="state variable" id="_f39cf7c2-774e-43eb-b778-e91efffef200"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="6979.1675" y="7080.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3073_csa61" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: The complex participates in the HR and S-checkpoint PMID:12239151, PMID:19686080 For Fanconi PMID:19622404 The complex is considered to be the actual repair structure of the pathway. MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559 References_end</body> </html> </notes> <label text="BRCA1/BRCA2/FANCD2/FANCI/H2AX*/NBS*/PCNA/RAD51/Tip60*"/> <bbox w="287.0" h="180.0" x="6981.472" y="7300.3564"/> <glyph class="macromolecule" id="s3074_sa635"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7083.472" y="7398.3564"/> </glyph> <glyph class="macromolecule" id="s3075_sa636"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7078.329" y="7354.047"/> <glyph class="state variable" id="_37d1f7c2-2abc-4f59-82f6-73856c40676f"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7140.829" 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x="7150.415" y="7389.047"/> </glyph> </glyph> <glyph class="macromolecule" id="s3076_sa637"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="6996.0435" y="7398.0703"/> <glyph class="state variable" id="_22bf3a36-4481-4ecf-9fde-7d1cd64de14a"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="6985.0273" y="7393.0703"/> </glyph> <glyph class="state variable" id="_419f11d2-bec6-41d2-af4d-f87cf8985dc6"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="6981.0435" y="7413.0703"/> </glyph> <glyph class="state variable" id="_98e7141c-0979-4c5b-a684-09d68441a8dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7014.475" y="7433.0703"/> </glyph> <glyph class="state variable" id="_ecaa6bae-6657-4055-907b-370e6a8b70ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6991.0435" y="7433.0703"/> </glyph> <glyph class="state variable" id="_74a4c64e-723f-420f-9462-20f66dec907b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7031.0435" y="7433.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s3077_sa638"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="6991.579" y="7308.0703"/> <glyph class="state variable" id="_7ee3f2fb-14f1-4dee-838f-d44f3047941b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6981.579" y="7306.003"/> </glyph> <glyph class="state variable" id="_809f23d9-9be2-4c74-a88d-af6ffe69e2d7"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="6974.079" y="7323.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s3078_sa639"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51A HUGO:RAD51, HGNC:9817, ENTREZ:5888, UNIPROT:Q06609 RAD51-like 1 (S. cerevisiae), RAD51B HUGO:RAD51L1, HGNC:9822, ENTREZ:5890, UNIPROT:Q86U92 RAD51 homolog C (S. cerevisiae) HUGO:RAD51C, HGNC:9820, ENTREZ:5889, UNIPROT:O43502 RAD51-like 3 (S. cerevisiae), RAD51D HUGO:RAD51L3, HGNC:9823, ENTREZ:5892, UNIPROT:O94908 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="80.0" h="40.0" x="7172.0435" y="7401.9277"/> </glyph> <glyph class="macromolecule" id="s3222_sa640"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="7080.722" y="7309.3564"/> <glyph class="state variable" id="_5752c375-9f79-4268-a0a7-0b619d966761"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="7063.222" y="7332.5405"/> </glyph> </glyph> <glyph class="macromolecule" id="s3080_sa641"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: K(lysine) acetyltransferase 5 HUGO:KAT5, HGNC:5275, ENTREZ:10524, UNIPROT:Q92993 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:12551922, PMID:11927554, PMID:21574959, PMID:18085520 References_end</body> </html> </notes> <label text="TIP60*"/> <bbox w="80.0" h="40.0" x="6993.0557" y="7353.1064"/> </glyph> <glyph class="macromolecule" id="s3170_sa642"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="7170.472" y="7359.0703"/> <glyph class="state variable" id="_0b17dc38-6360-4be1-9cdf-331ec03231d0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7242.972" y="7394.0703"/> </glyph> <glyph class="state variable" id="_14d87c29-cc83-4770-825b-a3b8a5e9496e"> <state value="Ub" variable="K523"/> <bbox w="40.0" h="10.0" x="7189.1763" y="7394.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s3169_sa643"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="7169.3354" y="7311.5"/> <glyph class="state variable" 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cycle-dependent manner PMID:15485915, PMID:19357644 References_end</body> </html> </notes> <label text="BRCA1/CtIP*"/> <bbox w="100.0" h="135.0" x="7324.472" y="5667.3564"/> <glyph class="macromolecule" id="s1092_sa582"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="7336.916" y="5734.192"/> <glyph class="state 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="7334.897" y="5683.013"/> <glyph class="state variable" id="_0fa5fe06-4f5d-4d45-9113-775b13377d8f"> <state value="P" variable="S1387"/> <bbox w="40.0" h="10.0" x="7394.897" y="5683.2524"/> </glyph> <glyph class="state variable" id="_83be92e8-51cf-470e-92ae-df46c983f0e9"> <state value="P" variable="S988"/> <bbox w="35.0" 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Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="7085.722" y="5736.4487"/> <glyph class="state variable" id="_3a3719f1-ca74-4033-91bf-fead1e66393a"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="7068.222" y="5759.633"/> </glyph> </glyph> <glyph class="macromolecule" id="s2800_sa562"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="6999.472" y="5663.3564"/> <glyph class="state variable" id="_368adf48-e531-4924-9e00-eda7a51246c8"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="7061.972" y="5663.5957"/> </glyph> <glyph class="state variable" id="_676ebaa8-9f1c-4a05-b6ea-a4c3a49316a9"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="7039.334" y="5658.3564"/> </glyph> <glyph class="state variable" id="_ed62b428-c72d-4012-854c-8c46531d16a1"> <state value="" variable="S1497"/> <bbox w="35.0" h="10.0" x="7019.2236" 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protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="7000.686" y="5709.4297"/> <glyph class="state variable" id="_e3606f30-a5a0-4afa-8986-9043d57224b8"> <state value="P" variable="S372"/> <bbox w="35.0" h="10.0" x="7006.7812" y="5704.4297"/> </glyph> <glyph class="state variable" id="_1b6ff367-c612-4615-89e7-470140548d30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6995.686" y="5724.4297"/> </glyph> <glyph class="state variable" id="_5d3a7362-e0f4-415d-81f1-ff7240c8f792"> <state value="P" variable="S267"/> <bbox w="35.0" h="10.0" 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MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="7089.972" y="5653.8564"/> </glyph> <glyph class="macromolecule" id="s2796_sa565"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="7088.972" y="5693.8564"/> </glyph> <glyph class="macromolecule" id="s3355_sa1572"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="79.0" h="40.0" x="7085.0557" y="5779.6895"/> <glyph class="state variable" id="_68596060-9574-4878-8184-4fdf870fed7c"> <state value="?" variable="PolyADPribose"/> <bbox w="79.0" 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<body>Identifiers_begin: poly (ADP-ribose) polymerase 2 HUGO:PARP2, HGNC:272, ENTREZ:10038, Q9UGN5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARPs in cellular functions PMID:22713970 PARP1 and PARP2 in HR and in inhibition of C_NHEJ PMID:22469522, PMID:196269035 PARP2 in chromatin remodeling PMID:22469522, PMID:22713970 References_end</body> </html> </notes> <label text="PARP2"/> <bbox w="80.0" h="40.0" x="6994.1865" y="5774.7847"/> <glyph class="state variable" id="_7aaad32f-f490-465b-8f87-0fc479336d09"> <state value="P" variable=""/> <bbox 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<body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1, HGNC:3113, ENTREZ:1869, UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="4460.502" y="4065.844"/> <glyph class="state variable" id="_0c10ec04-97f5-4d88-9ecb-e3eb8d04d9c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4535.502" y="4080.844"/> </glyph> </glyph> <glyph class="macromolecule" id="s2582_sa1178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma 1 HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440 References_end</body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="4457.502" y="4026.844"/> <glyph class="state variable" id="_b2516f81-6f48-4cc6-8406-4fdb447f6656"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4532.502" y="4041.844"/> </glyph> </glyph> <glyph class="macromolecule" id="s2581_sa1180"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="4455.5425" y="3985.5786"/> <glyph class="state variable" id="_c4a322ab-9851-4771-9a26-74a38f5514f2"> <state value="P" variable="S1387"/> <bbox w="40.0" h="10.0" x="4515.5425" y="3985.8179"/> </glyph> <glyph class="state variable" id="_1cf35cd9-cf93-422a-8e8a-a9b7657e516c"> <state value="P" variable="S988"/> <bbox w="35.0" h="10.0" x="4492.9043" y="3980.5786"/> </glyph> <glyph class="state variable" id="_c52bd76f-a39d-4bad-8d60-cdf8a28592cd"> <state value="P" variable="S1497"/> <bbox w="40.0" h="10.0" x="4472.794" y="3980.5786"/> </glyph> <glyph class="state variable" id="_83cbe7d2-f15e-49e8-987e-76394765ef22"> <state value="P" variable="S1423"/> <bbox w="40.0" h="10.0" x="4454.6694" y="3980.5786"/> </glyph> <glyph class="state variable" 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Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. 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This is a switch mechanism PMID:20173781 References_end</body> </html> </notes> <label text="FANCJ*"/> <bbox w="80.0" h="40.0" x="7091.972" y="6516.8564"/> <glyph class="state variable" id="_02ef66d6-aafc-4bca-9a6e-678fdcbce5e1"> <state value="P" variable="S990"/> <bbox w="35.0" h="10.0" x="7114.504" y="6511.8564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2889_csa240" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA1:SMC1* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="BRCA1/SMC1*"/> <bbox w="113.0" h="121.0" x="6735.472" y="532.35626"/> <glyph class="macromolecule" id="s2890_sa1285"> <notes> <html 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<head> <title/> </head> <body>Identifiers_begin: breast cancer 1, early onset HUGO:BRCA1, HGNC:1100, ENTREZ:672, UNIPROT:P38398 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331 References_end</body> </html> </notes> <label text="BRCA1"/> <bbox w="80.0" h="40.0" x="6612.9497" y="546.34894"/> <glyph class="state variable" id="_4c76ac34-0158-4736-9218-0d24b7401b30"> <state value="" variable="S1387"/> <bbox w="35.0" h="10.0" x="6675.4497" y="546.58826"/> </glyph> <glyph class="state variable" id="_2c3ad5f0-bd97-47cc-a6c5-8d39d7c91f13"> <state value="" variable="S988"/> <bbox w="30.0" h="10.0" x="6652.8115" y="541.34894"/> </glyph> <glyph class="state variable" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Structural maintenance of chromosomes 3 HUGO:SMC3, HGNC:2468, ENTREZ:9126, UNIPROT:Q9UQE7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC3"/> <bbox w="80.0" h="40.0" x="6612.1997" y="595.34894"/> <glyph class="state variable" id="_7c56d6d3-ed83-484f-ae45-98fa8e323db5"> <state value="P" variable="S1083"/> <bbox w="40.0" h="10.0" x="6645.094" y="590.34894"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1035_csa54" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA2:DSS1* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="BRCA2/DSS1*"/> <bbox w="96.0" h="111.0" x="7549.472" y="6912.3564"/> <glyph class="macromolecule" id="s1037_sa601"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7555.649" y="6917.588"/> </glyph> <glyph class="macromolecule" id="s1036_sa602"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: split hand/foot malformation (ectrodactyly) type 1 HUGO:SHFM1, HGNC:10845 ENTREZ:7979, UNIPROT:P60896 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="DSS1*"/> <bbox w="80.0" h="40.0" x="7555.649" y="6957.588"/> </glyph> </glyph> <glyph class="complex" id="s1356_csa81" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRCA2:FANCC:FANCG:XRCC3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="BRCA2/FANCC/FANCG/XRCC3"/> <bbox w="200.0" h="109.0" x="6986.472" y="5855.3564"/> <glyph class="macromolecule" id="s1352_sa698"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: breast cancer 2, early onset, FANCD1 HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="BRCA2"/> <bbox w="80.0" h="40.0" x="7007.615" y="5860.9277"/> </glyph> <glyph class="macromolecule" id="s1353_sa699"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group G HUGO:FANCG, HGNC:3588, UNIPROT:O15287 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCG"/> <bbox w="80.0" h="40.0" x="7010.6865" y="5904.499"/> <glyph class="state variable" id="_19d58c57-6b0b-4824-83e9-b2e6db5c3a9f"> <state value="P" variable="S7"/> <bbox w="25.0" h="10.0" x="7021.7817" y="5899.499"/> </glyph> </glyph> <glyph class="macromolecule" id="s1354_sa700"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 3 HUGO:XRCC3, HGNC:12830, ENTREZ:7517, UNIPROT:O43542 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC3"/> <bbox w="80.0" h="40.0" x="7093.0435" y="5899.9277"/> </glyph> <glyph class="macromolecule" id="s1355_sa701"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group C HUGO:FANCC, HGNC:3584, ENTREZ:2176, UNIPROT:Q00597 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCC"/> <bbox w="80.0" h="40.0" x="7089.329" y="5859.9277"/> </glyph> </glyph> <glyph class="complex" id="s1138_csa60" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:SKP1:SKP2:_beta_TRCP* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. 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PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="80.0" h="40.0" x="5462.972" y="1707.8562"/> </glyph> <glyph class="macromolecule" id="s68_sa791"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1, HGNC:1722, ENTREZ:983, UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="5462.972" y="1748.8562"/> <glyph 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h="105.0" x="5891.472" y="1704.3562"/> <glyph class="macromolecule" id="s3206_sa768"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin B1 HUGO:CCNB1, HGNC:1579, ENTREZ:891, UNIPROT:P14635 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="80.0" h="40.0" x="5904.972" y="1707.8562"/> </glyph> <glyph class="macromolecule" id="s2259_sa769"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1, HGNC:1722, ENTREZ:983, UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="5904.972" y="1748.8562"/> <glyph class="state variable" id="_64dc0ead-d248-427d-b9ad-3ed379e5dbbd"> <state value="P" variable="T161"/> <bbox w="35.0" h="10.0" x="5967.472" y="1763.4562"/> </glyph> <glyph class="state variable" id="_697119fe-f1b8-4516-8764-49428b802930"> <state value="" variable="Y14/15"/> <bbox w="40.0" h="10.0" x="5941.9214" y="1743.8562"/> </glyph> <glyph class="state variable" 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Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="80.0" h="40.0" x="6105.502" y="1686.3152"/> </glyph> <glyph class="macromolecule" id="s2517_sa1137"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB, HGNC:12849, ENTREZ:7529, UNIPROT:P31946 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG, HGNC:12852, ENTREZ:7532, UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH, HGNC:12853, ENTREZ:7533, UNIPROT:Q04917 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE, HGNC:12851, ENTREZ:7531, UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ, HGNC:12854, ENTREZ:10971, UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ, HGNC:12855, ENTREZ:7534, UNIPROT:Q6NUR9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6110.31" y="1767.1295"/> </glyph> <glyph class="macromolecule" id="s2875_sa1270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1, HGNC:1722, ENTREZ:983, UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="6107.4585" y="1728.0807"/> <glyph class="state variable" id="_388584ee-2e48-4fbc-89f1-f2b9fa33cf5d"> <state value="P" variable="T161"/> <bbox w="35.0" h="10.0" x="6169.9585" y="1742.6807"/> </glyph> <glyph class="state variable" id="_1c1aec29-f0a6-4fbd-8894-ea2918cc52e1"> <state value="" variable="Y14/15"/> <bbox w="40.0" h="10.0" x="6144.4077" y="1723.0807"/> </glyph> <glyph class="state variable" id="_09343759-1f13-4c89-b6b1-db93fd99a50f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6102.4585" y="1743.0488"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1664_csa100" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK1:CyclinB1*:GADD45A Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G2_M_CHECKPOINT MODULE:NER Maps_Modules_end References_begin: CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in response to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CDC2*/CycB*/GADD45A"/> <bbox w="141.0" h="158.0" x="4955.472" y="4752.3564"/> <glyph class="macromolecule" id="s1667_sa743"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Growth arrest and DNA-damage-inducible, alpha HUGO:GADD45A, HGNC:4095, ENTREZ:1647, UNIPROT:P24522 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19004803 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 Role in BER PMID:23485469 References_end</body> </html> </notes> <label text="GADD45A"/> <bbox w="80.0" h="40.0" x="4984.329" y="4848.2134"/> </glyph> <glyph class="macromolecule" id="s1666_sa745"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1, HGNC:1722, ENTREZ:983, UNIPROT:P06493 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="4984.758" y="4763.642"/> <glyph class="state variable" id="_b66b6a5d-6067-4cf6-a0d4-347ddfc7a6c6"> <state value="" variable="T161"/> <bbox w="30.0" h="10.0" x="5049.758" y="4778.242"/> </glyph> <glyph class="state variable" id="_2fd33c4b-2f91-4be3-a0a7-41e896c44f79"> <state value="" variable="Y14/15"/> <bbox w="40.0" h="10.0" x="5021.707" y="4758.642"/> </glyph> <glyph class="state variable" id="_d17703de-3c59-497c-94a7-cce94c240aee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4979.758" y="4778.6104"/> </glyph> </glyph> <glyph class="macromolecule" id="s3207_sa1484"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin B1 HUGO:CCNB1, HGNC:1579, ENTREZ:891, UNIPROT:P14635 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 References_end</body> </html> </notes> <label text="CyclinB1*"/> <bbox w="80.0" h="40.0" x="4984.296" y="4805.239"/> </glyph> </glyph> <glyph class="complex" id="s2523_csa226" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:CDC25B Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="CDC25B/14-3-3*"/> <bbox w="101.0" h="126.0" x="5066.472" y="1414.3562"/> <glyph class="macromolecule" id="s2524_sa1143"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB, HGNC:12849, ENTREZ:7529, UNIPROT:P31946 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG, HGNC:12852, ENTREZ:7532, UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH, HGNC:12853, ENTREZ:7533, UNIPROT:Q04917 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE, HGNC:12851, ENTREZ:7531, UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ, HGNC:12854, ENTREZ:10971, UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ, HGNC:12855, ENTREZ:7534, UNIPROT:Q6NUR9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5079.751" y="1473.247"/> </glyph> <glyph class="macromolecule" id="s2532_sa1149"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 25 homolog B (S. pombe) HUGO:CDC25B, HGNC:1726, ENTREZ:994, UNIPROT:P30305 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25B"/> <bbox w="80.0" h="40.0" x="5082.5474" y="1431.3638"/> <glyph class="state variable" id="_dc6c164c-a23c-434d-8191-6e0cff324da8"> <state value="P" variable="S230"/> <bbox w="35.0" h="10.0" x="5065.0474" y="1446.3319"/> </glyph> <glyph class="state variable" id="_64bac402-b737-4464-9feb-73e6aa7c7b77"> <state value="" variable="S353"/> <bbox w="30.0" h="10.0" x="5124.027" y="1426.3638"/> </glyph> <glyph class="state variable" id="_d48530c3-a2c3-4a9f-b94e-a953dd92cdd5"> <state value="P" variable="S323"/> <bbox w="35.0" h="10.0" x="5065.0474" y="1457.2485"/> </glyph> <glyph class="state variable" id="_8ef7aeb4-513c-4840-98e3-9b56837c0f86"> <state value="P" variable="S151"/> <bbox w="35.0" h="10.0" x="5065.0474" y="1435.6208"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2526_csa227" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:CDC25C Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="CDC25C/14-3-3*"/> <bbox w="96.0" h="128.0" x="5381.472" y="1417.3562"/> <glyph class="macromolecule" id="s2527_sa1144"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide HUGO:YWHAB, HGNC:12849, ENTREZ:7529, UNIPROT:P31946 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide HUGO:YWHAG, HGNC:12852, ENTREZ:7532, UNIPROT:P61981 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide HUGO:YWHAH, HGNC:12853, ENTREZ:7533, UNIPROT:Q04917 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide HUGO:YWHAE, HGNC:12851, ENTREZ:7531, UNIPROT:P62258 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide HUGO:YWHAQ, HGNC:12854, ENTREZ:10971, UNIPROT:P27348 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide HUGO:YWHAZ, HGNC:12855, ENTREZ:7534, UNIPROT:Q6NUR9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5391.097" y="1481.9612"/> </glyph> <glyph class="macromolecule" id="s2531_sa1148"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 25 homolog C (S. pombe) HUGO:CDC25C, HGNC:1727, ENTREZ:995, UNIPROT:P30307 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_CC_PHASE Maps_Modules_end References_begin: PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC25C"/> <bbox w="80.0" h="40.0" x="5393.3457" y="1434.3638"/> <glyph class="state variable" id="_410bcf3c-2308-43c1-aaa6-bb25ab014f8c"> <state value="P" variable="S191"/> <bbox w="35.0" h="10.0" x="5375.8457" y="1449.7319"/> </glyph> <glyph class="state variable" id="_fb4e1a7f-ef63-40b7-b816-9538650cfcf8"> <state value="" variable="S216"/> <bbox w="30.0" h="10.0" x="5435.295" y="1429.3638"/> </glyph> <glyph class="state variable" id="_d4ec59b3-ac83-406d-8203-974d6937b892"> <state value="P" variable="S214"/> <bbox w="35.0" h="10.0" x="5376.732" y="1469.3638"/> </glyph> <glyph class="state variable" id="_de5ebc61-4461-450e-af69-ddb978dcbeb9"> <state value="P" variable="S198"/> <bbox w="35.0" h="10.0" x="5375.8457" y="1436.6099"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2220_csa199" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDC6/CDT1/MCM2/MCM3/MCM4/MCM5/MCM6/MCM7/ORC1*/ORC2*/ORC3*/ORC4*/ORC5*/ORC6*/POLA*/PRIM*/RPA1/RPA2/RPA3"/> <bbox w="438.0" h="198.0" x="5931.472" y="532.35626"/> <glyph class="macromolecule" id="s2654_sa888"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 6-like (yeast) HUGO:ORC6L, HGNC:17151, ENTREZ:23594, UNIPROT:Q9Y5N6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC6*"/> <bbox w="80.0" h="40.0" x="6020.564" y="626.1618"/> </glyph> <glyph class="macromolecule" id="s2652_sa889"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 5-like (yeast) HUGO:ORC5L, HGNC:8491, ENTREZ:5001, UNIPROT:O43913 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC5*"/> <bbox w="80.0" h="40.0" x="6019.564" y="582.1618"/> </glyph> <glyph class="macromolecule" id="s2650_sa890"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 4-like (yeast) HUGO:ORC4L, HGNC:8490, ENTREZ:5000, UNIPROT:O43929 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC4*"/> <bbox w="80.0" h="40.0" x="6018.564" y="540.1618"/> </glyph> <glyph class="macromolecule" id="s2663_sa891"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 3-like (yeast) HUGO:ORC3L, HGNC:8489, ENTREZ:23595, UNIPROT:Q9UNT6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC3*"/> <bbox w="80.0" h="40.0" x="5938.564" y="627.1618"/> </glyph> <glyph class="macromolecule" id="s2664_sa892"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 2-like (yeast) HUGO:ORC2L, HGNC:8488, ENTREZ:4999, UNIPROT:Q13416 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC2*"/> <bbox w="80.0" h="40.0" x="5935.564" y="583.1618"/> </glyph> <glyph class="macromolecule" id="s2665_sa893"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 1-like (yeast) HUGO:ORC1L, HGNC:8487, ENTREZ:4998, UNIPROT:Q13415 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC1*"/> <bbox w="80.0" h="40.0" x="5938.564" y="540.1618"/> </glyph> <glyph class="macromolecule" id="s2662_sa894"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 2 HUGO:MCM2, HGNC:6944, ENTREZ:4171, UNIPROT:P49736 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM2"/> <bbox w="80.0" h="40.0" x="6104.2153" y="541.1123"/> </glyph> <glyph class="macromolecule" id="s2658_sa895"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 3 HUGO:MCM3, HGNC:6945, ENTREZ:4172, UNIPROT:P25205 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM3"/> <bbox w="80.0" h="40.0" x="6103.2153" y="584.1123"/> </glyph> <glyph class="macromolecule" id="s2660_sa896"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 4 HUGO:MCM4, HGNC:6947, ENTREZ:4173, UNIPROT:P33991 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM4"/> <bbox w="80.0" h="40.0" x="6103.2153" y="627.1123"/> </glyph> <glyph class="macromolecule" id="s2661_sa897"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 7 HUGO:MCM7, HGNC:6950, ENTREZ:4176, UNIPROT:P33993 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM7"/> <bbox w="80.0" h="40.0" x="6186.2153" y="626.1123"/> </glyph> <glyph class="macromolecule" id="s2659_sa898"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 6 HUGO:MCM6, HGNC:6949, ENTREZ:4175, UNIPROT:Q14566 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM6"/> <bbox w="80.0" h="40.0" x="6188.2153" y="584.1123"/> </glyph> <glyph class="macromolecule" id="s2657_sa899"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 5 HUGO:MCM5, HGNC:6948, ENTREZ:4174, UNIPROT:P33992 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM5"/> <bbox w="80.0" h="40.0" x="6185.2153" y="540.1123"/> </glyph> <glyph class="macromolecule" id="s2236_sa901"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 6 homolog (S. cerevisiae) HUGO:CDC6, HGNC:1744, ENTREZ:990, UNIPROT:Q99741 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC6"/> <bbox w="80.0" h="40.0" x="6024.5938" y="666.9843"/> </glyph> <glyph class="macromolecule" id="s2237_sa902"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromatin licensing and DNA replication factor 1 HUGO:CDT1, HGNC:24576, ENTREZ:81620, UNIPROT:Q9H211 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDT1"/> <bbox w="80.0" h="40.0" x="6108.5938" y="668.9843"/> </glyph> <glyph class="macromolecule" id="s2267_sa917"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), alpha 1, catalytic subunit HUGO:POLA1, HGNC:9173, ENTREZ:5422, UNIPROT:P09884 polymerase (DNA directed), alpha 2 (70kD subunit) HUGO:POLA2, HGNC:30073, ENTREZ:23649, UNIPROT:Q14181 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="POLA*"/> <bbox w="80.0" h="40.0" x="6192.472" y="670.35626"/> </glyph> <glyph class="macromolecule" id="s2269_sa920"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: primase, DNA, polypeptide 1 (49kDa) HUGO:PRIM1, HGNC:9369, ENTREZ:5557, UNIPROT:P49642 primase, DNA, polypeptide 2 (58kDa) HUGO:PRIM2, HGNC:9370, ENTREZ:5558, UNIPROT:P49643 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="PRIM*"/> <bbox w="80.0" h="40.0" x="6276.31" y="668.86304"/> </glyph> <glyph class="macromolecule" id="s2648_sa921"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="6276.059" y="544.33203"/> </glyph> <glyph class="macromolecule" id="s2646_sa922"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="6276.059" y="586.33203"/> <glyph class="state variable" id="_05a1a127-5934-4e30-bafd-a111627e30a5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6271.059" y="601.33203"/> </glyph> </glyph> <glyph class="macromolecule" id="s2647_sa923"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="6276.059" y="626.33203"/> </glyph> <glyph class="macromolecule" id="s3435_sa1624"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cell division cycle 45 homolog (S. cerevisiae) HUGO:CDC45, HGNC:1739, ENTREZ:8318, UNIPROT:O75419 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17608804, PMID:17887956, PMID:12185086, PMID:10882098, PMID:21527023, PMID:21406556, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC45"/> <bbox w="80.0" h="40.0" x="5940.472" y="667.6896"/> </glyph> </glyph> <glyph class="complex" id="s2243_csa203" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDC7:DBF4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDC7/DBF4"/> <bbox w="93.0" h="111.0" x="5936.472" y="786.35626"/> <glyph class="macromolecule" id="s2244_sa905"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DBF4 homolog (S. cerevisiae) HUGO:DBF4, HGNC:17364, ENTREZ:10926, UNIPROT:Q9UBU7 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17018296, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="DBF4"/> <bbox w="80.0" h="40.0" x="5941.472" y="789.35626"/> </glyph> <glyph class="macromolecule" id="s2245_sa906"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 7 homolog (S. cerevisiae) HUGO:CDC7, HGNC:1745, ENTREZ:8317, UNIPROT:O00311 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17018296, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDC7"/> <bbox w="80.0" h="40.0" x="5944.011" y="832.3849"/> </glyph> </glyph> <glyph class="complex" id="s1773_csa106" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK2:CIP1_KIP1*:CyclinA1* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK2/CIP/KIP*/CycA*"/> <bbox w="102.0" h="152.0" x="5390.472" y="202.35626"/> <glyph class="macromolecule" id="s55_sa758"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2, HGNC:1771, ENTREZ:1017, UNIPROT:P24941 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17303408, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK2"/> 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CIP1_KIP1*:CyclinD* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G1_CC_PHASE Maps_Modules_end References_begin: p53-dependentG1/S checkpoint References_end</body> </html> </notes> <label text="CDK4,6*/CIP/KIP*/CycD*"/> <bbox w="118.0" h="150.0" x="4369.472" y="593.35626"/> <glyph class="macromolecule" id="s1794_sa751"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 Cyclin-dependent kinase 6 HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="4383.472" y="639.85626"/> <glyph class="state variable" id="_15bd83c5-21ec-4b23-bb75-6d02d9cfc193"> <state value="" variable="Y14"/> <bbox w="25.0" h="10.0" x="4392.406" y="634.85626"/> </glyph> <glyph class="state variable" id="_a7a8551d-b146-4dc8-b696-10b0906b3068"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="4368.472" y="654.85626"/> </glyph> </glyph> <glyph class="macromolecule" id="s1950_sa752"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 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HUGO:CDKN1B, HGNC:1785, ENTREZ:1027, UNIPROT:P46527 cyclin-dependent kinase inhibitor 1C (p57, Kip2) HUGO:CDKN1C, HGNC:1786, ENTREZ:1028, UNIPROT:P49918 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CIP1_KIP1*"/> <bbox w="80.0" h="40.0" x="4384.472" y="679.85626"/> </glyph> </glyph> <glyph class="complex" id="s3336_csa124" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK4,6*/CycD*"/> <bbox w="100.0" h="111.0" x="3792.4722" y="761.35626"/> <glyph class="macromolecule" id="s3337_sa801"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 Cyclin-dependent kinase 6 HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="3802.4722" y="812.85626"/> <glyph class="state variable" id="_76cffe0a-86a1-426a-bc54-bf08800a7233"> <state value="" variable="Y14"/> <bbox w="25.0" h="10.0" x="3811.4058" y="807.85626"/> </glyph> <glyph class="state variable" id="_15525df9-6d42-463d-a269-1221b728c4ee"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="3787.4722" y="827.85626"/> </glyph> </glyph> <glyph class="macromolecule" id="s2048_sa802"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="3801.4722" y="765.85626"/> <glyph class="state variable" id="_6db8aa61-4cd1-4462-87cf-c15776abc54d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3793.9722" y="780.85626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3133_csa127" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK4,6*/CycD*"/> <bbox w="99.0" h="107.0" x="3926.4722" y="593.35626"/> <glyph class="macromolecule" id="s1964_sa807"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="3936.4722" y="596.85626"/> <glyph class="state variable" id="_3089c337-1ee6-49d3-8a45-8f8075ef7dd6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3931.4722" y="611.85626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3131_csa126" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK4,6*/CycD*"/> <bbox w="100.0" h="111.0" x="3792.4722" y="593.35626"/> <glyph class="macromolecule" id="s3130_sa805"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 Cyclin-dependent kinase 6 HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="3802.4722" y="644.85626"/> <glyph class="state variable" id="_4e14a6ee-395e-4b66-8493-530adc33d3f5"> <state value="" variable="Y14"/> <bbox w="25.0" h="10.0" x="3811.4058" y="639.85626"/> </glyph> <glyph class="state variable" id="_5bfa3abe-611f-4f9a-a6e2-cbe7c6a8d7c7"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="3787.4722" y="659.85626"/> </glyph> </glyph> <glyph class="macromolecule" id="s3338_sa806"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="3798.4722" y="597.85626"/> <glyph class="state variable" id="_3c985948-cd98-4cea-b0c1-52be1c6a4cf1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3793.4722" y="612.85626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3129_csa128" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK4,6*/CycD*"/> <bbox w="99.0" h="107.0" x="4069.4722" y="593.35626"/> <glyph class="macromolecule" id="s1968_sa809"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 Cyclin-dependent kinase 6 HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="4079.4722" y="636.85626"/> <glyph class="state variable" id="_d349d8db-0cf1-4415-9190-e8831a377a27"> <state value="P" variable="Y14"/> <bbox w="30.0" h="10.0" x="4085.9058" y="631.85626"/> </glyph> 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class="state variable" id="_40891c24-ca55-48e1-b7d3-13c28f791180"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4074.4722" y="611.85626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2164_csa129" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK4,6*/CycD*"/> <bbox w="99.0" h="107.0" x="4216.472" y="593.35626"/> <glyph class="macromolecule" id="s1971_sa811"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 Cyclin-dependent kinase 6 HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="4224.472" y="639.85626"/> <glyph class="state variable" id="_628ed349-249e-4947-8168-143499594d5e"> <state value="" variable="Y14"/> <bbox w="25.0" h="10.0" x="4233.406" y="634.85626"/> </glyph> <glyph class="state variable" id="_8f445d6d-09cb-465a-b438-db23a39051ae"> <state value="P" variable="T172"/> <bbox w="35.0" h="10.0" x="4206.972" y="654.85626"/> </glyph> </glyph> <glyph class="macromolecule" id="s2167_sa812"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin D1 HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385 Cyclin D2 HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279 Cyclin D3 HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="4226.472" y="596.85626"/> <glyph class="state variable" id="_ca2590cb-5233-448f-b111-dcd1378ddd31"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4221.472" y="611.85626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s31_csa104" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:INK4* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDK4,6*/INK4"/> <bbox w="105.0" h="106.0" x="3789.4722" y="463.35626"/> <glyph class="macromolecule" id="s1908_sa754"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802 Cyclin-dependent kinase 6 HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="3800.4722" y="508.85626"/> <glyph class="state variable" id="_1f618364-068e-42a6-ac89-7978f3c696de"> <state value="" variable="Y14"/> <bbox w="25.0" h="10.0" x="3809.4058" y="503.85626"/> </glyph> <glyph class="state variable" id="_e49ca6ce-49df-44d5-a3a5-85a24b159230"> <state value="" variable="T172"/> <bbox w="30.0" h="10.0" x="3785.4722" y="523.85626"/> </glyph> </glyph> <glyph class="macromolecule" id="s2488_sa755"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), p16INK4A, p19ARF HUGO:CDKN2A, HGNC:1787, ENTREZ:1029, UNIPROT:Q8N726 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), p15INK4b HUGO:CDKN2B, HGNC:1788, ENTREZ:1030, UNIPROT:P42772 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), INK4C HUGO:CDKN2C, HGNC:1789, ENTREZ:1031, UNIPROT:P42773 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4), INK4D HUGO:CDKN2D, NC:1790, ENTREZ:1032, UNIPROT:P55273 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="INK4*"/> <bbox w="80.0" h="40.0" x="3799.4722" y="468.35626"/> </glyph> </glyph> <glyph class="complex" id="s3375_csa272" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK5:EME1:STAT3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="CDK5/EME1/STAT3"/> <bbox w="111.0" h="160.0" x="6954.472" y="8216.356"/> <glyph class="macromolecule" id="s3376_sa1587"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: essential meiotic endonuclease 1 homolog 1 (S. pombe) HUGO:EME1, HGNC:24965, ENTREZ:146956, UNIPROT:Q96AY2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="EME1"/> <bbox w="80.0" h="40.0" x="6974.472" y="8223.022"/> </glyph> <glyph class="macromolecule" id="s3374_sa1588"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: signal transducer and activator of transcription 3 (acute-phase response factor) HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 Identifiers_end</body> </html> </notes> <label text="STAT3"/> <bbox w="80.0" h="40.0" x="6972.472" y="8269.356"/> <glyph class="state variable" id="_079bb8dc-3ab1-4a50-8f64-8157ae525e75"> <state value="P" variable="Ser727"/> <bbox w="45.0" h="10.0" x="7003.8945" y="8264.356"/> </glyph> </glyph> <glyph class="macromolecule" id="s3377_sa1589"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 5 HUGO:CDK5 HGNC:1774 ENTREZ:1020 UNIPROT:Q00535 Identifiers_end Maps_Modules_begin: MODULE:BER MODULE:DNA_REPAIR Maps_Modules_end References_begin: Triple phosphorylation by CDK5 inhibits PARP1 PMID:21922195 Stabilisation of USP1 by phosphorylaton by CDK5 PMID:23589330 References_end</body> </html> </notes> <label text="CDK5"/> <bbox w="80.0" h="40.0" x="6971.8057" y="8313.356"/> </glyph> </glyph> <glyph class="complex" id="s533_csa11" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK7:CyclinH*:ERCC1:MNAT1:RPA1:RPA2:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA:XPB*:XPD*:XPF*:XPG* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="CDK7/CycH*/ERCC1/MNAT1/TFB5*/TFIIH1*/TFIIH2*/TFIIH3*/TFIIH4*/TTDA*/RPA1/RPA2/RPA3/XAB2/XPA/XPB*/XPD*/XPF*/XPG*"/> <bbox w="375.0" h="264.0" x="744.47217" y="7241.3564"/> <glyph class="macromolecule" id="s2720_sa1224"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 5 HUGO:GTF2H5, HGNC:21157, ENTREZ:404672, UNIPROT:Q6ZYL4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH5*"/> <bbox w="80.0" h="40.0" x="764.2347" y="7332.4375"/> </glyph> <glyph class="macromolecule" id="s2719_sa1225"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 2 HUGO:ERCC2, HGNC:3434, ENTREZ:2068, UNIPROT:P18074 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPD*"/> <bbox w="80.0" h="40.0" x="764.2347" y="7295.1875"/> </glyph> <glyph class="macromolecule" id="s2724_sa1226"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) HUGO:ERCC3, HGNC:3435, ENTREZ:2071, UNIPROT:P19447 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPB*"/> <bbox w="80.0" h="40.0" x="762.2347" y="7253.9375"/> </glyph> <glyph class="macromolecule" id="s2709_sa1227"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 1, 62kDa HUGO:GTF2H1, HGNC:4655, ENTREZ:HGNC:2965, UNIPROT:P32780 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH1*"/> <bbox w="80.0" h="40.0" x="850.2347" y="7256.4375"/> </glyph> <glyph class="macromolecule" id="s2710_sa1228"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 2, 44kDa HUGO:GTF2H2, HGNC:4656, ENTREZ:2966, UNIPROT:Q13888 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH2*"/> <bbox w="80.0" h="40.0" x="850.2347" y="7291.4375"/> </glyph> <glyph class="macromolecule" id="s2711_sa1229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 3, 34kDa HUGO:GTF2H3, HGNC:4657, ENTREZ:2967, UNIPROT:Q13889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH3*"/> <bbox w="80.0" h="40.0" x="851.2347" y="7331.4375"/> </glyph> <glyph class="macromolecule" id="s2712_sa1230"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 4, 52kDa HUGO:GTF2H4, HGNC:4658, ENTREZ:2968, UNIPROT:Q92759 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH4*"/> <bbox w="80.0" h="40.0" x="852.2347" y="7373.4375"/> </glyph> <glyph class="macromolecule" id="s2722_sa1232"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) HUGO:MNAT1 , HGNC:7181, ENTREZ:4331, UNIPROT:P51948 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G,PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="MNAT1"/> <bbox w="80.0" h="40.0" x="761.2347" y="7371.4375"/> </glyph> <glyph class="macromolecule" id="s2723_sa1233"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 7 HUGO:CDK7, HGNC:1778, ENTREZ:1022, UNIPROT:P50613 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 CDK7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II References_end</body> </html> </notes> <label text="CDK7"/> <bbox w="80.0" h="40.0" x="762.2347" y="7414.4375"/> </glyph> <glyph class="macromolecule" id="s2713_sa1234"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CyclinH HUGO:CCNH, HGNC:1594, ENTREZ:902, UNIPROT:P51946 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery: PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="CyclinH*"/> <bbox w="80.0" h="40.0" x="851.2347" y="7416.4375"/> </glyph> <glyph class="macromolecule" id="s2727_sa1240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) HUGO:ERCC1, HGNC:3433, ENTREZ:2067, UNIPROT:P07992 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G, PMID:11900249 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="ERCC1"/> <bbox w="80.0" h="40.0" x="1028.7284" y="7262.647"/> </glyph> <glyph class="macromolecule" id="s2725_sa1241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 4 HUGO:ERCC4, HGNC:3436, ENTREZ:2072, UNIPROT:Q92889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:22101340, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For Fanconi pathway PMID:19686080 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XPF*"/> <bbox w="80.0" h="40.0" x="1028.7284" y="7305.147"/> </glyph> <glyph class="macromolecule" id="s2726_sa1242"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 5 HUGO:ERCC5, HGNC:3437, ENTREZ:2073, UNIPROT:P28715 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPG*"/> <bbox w="80.0" h="40.0" x="1029.7284" y="7350.647"/> </glyph> <glyph class="macromolecule" id="s2732_sa1243"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="942.5231" y="7413.2896"/> </glyph> <glyph class="macromolecule" id="s2728_sa1244"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="943.18414" y="7373.084"/> <glyph class="state variable" id="_dfa37d28-afd1-42a1-9a70-4672e7b3f0ee"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="935.68414" y="7388.084"/> </glyph> </glyph> <glyph class="macromolecule" id="s2729_sa1245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="943.5231" y="7339.2896"/> </glyph> <glyph class="macromolecule" id="s2730_sa1246"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group A HUGO:XPA, HGNC:12814, ENTREZ:7507, UNIPROT:P23025 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470 PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPA"/> <bbox w="80.0" h="40.0" x="939.9338" y="7297.5757"/> <glyph class="state variable" id="_1dd5a659-1915-4fde-96d7-4be1f2f22811"> <state value="P" variable="S196"/> <bbox w="35.0" h="10.0" x="922.4338" y="7304.082"/> </glyph> </glyph> <glyph class="macromolecule" id="s2731_sa1247"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XPA binding protein 2 HUGO:XAB2, HGNC:14089, ENTREZ:56949, UNIPROT:Q9HCS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XAB2"/> <bbox w="80.0" h="40.0" x="939.11237" y="7259.004"/> </glyph> </glyph> <glyph class="complex" id="s1814_csa119" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK7:CyclinH*:MNAT1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="CDK7/CycH*/MNAT1"/> <bbox w="96.0" h="147.0" x="4611.472" y="356.35626"/> <glyph class="macromolecule" id="s1819_sa787"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 7 HUGO:CDK7, HGNC:1778, ENTREZ:1022, UNIPROT:P50613 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 CDK7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II References_end</body> </html> </notes> <label text="CDK7"/> <bbox w="80.0" h="40.0" x="4619.7676" y="361.17444"/> </glyph> <glyph class="macromolecule" id="s1820_sa788"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) HUGO:MNAT1 , HGNC:7181, ENTREZ:4331, UNIPROT:P51948 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G,PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="MNAT1"/> <bbox w="80.0" h="40.0" x="4620.7676" y="445.17444"/> </glyph> <glyph class="macromolecule" id="s1901_sa789"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CyclinH HUGO:CCNH, HGNC:1594, ENTREZ:902, UNIPROT:P51946 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery: PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="CyclinH*"/> <bbox w="80.0" h="40.0" x="4620.6455" y="400.5012"/> </glyph> </glyph> <glyph class="complex" id="s674_csa9" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK7:CyclinH*:MNAT1:RPA1:RPA2:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA:XPB*:XPD* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="CDK7/CycH*/MNAT1/RPA1/RPA2/RPA3/TFB5*/TFIIH1*/TFIIH2*/TFIIH3*/TFIIH4*/TTDA*/XAB2/XPA/XPB*/XPD*"/> <bbox w="275.0" h="258.0" x="597.47217" y="6805.3564"/> <glyph class="macromolecule" id="s2698_sa1208"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 5 HUGO:GTF2H5, HGNC:21157, ENTREZ:404672, UNIPROT:Q6ZYL4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH5*"/> <bbox w="80.0" h="40.0" x="615.72845" y="6900.647"/> </glyph> <glyph class="macromolecule" id="s2697_sa1209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 2 HUGO:ERCC2, HGNC:3434, ENTREZ:2068, UNIPROT:P18074 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPD*"/> <bbox w="80.0" h="40.0" x="615.72845" y="6854.397"/> </glyph> <glyph class="macromolecule" id="s2702_sa1210"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) HUGO:ERCC3, HGNC:3435, ENTREZ:2071, UNIPROT:P19447 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPB*"/> <bbox w="80.0" h="40.0" x="615.72845" y="6813.147"/> </glyph> <glyph class="macromolecule" id="s2692_sa1211"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 1, 62kDa HUGO:GTF2H1, HGNC:4655, ENTREZ:HGNC:2965, UNIPROT:P32780 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH1*"/> <bbox w="80.0" h="40.0" x="697.72845" y="6815.647"/> </glyph> <glyph class="macromolecule" id="s2693_sa1212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 2, 44kDa HUGO:GTF2H2, HGNC:4656, ENTREZ:2966, UNIPROT:Q13888 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH2*"/> <bbox w="80.0" h="40.0" x="697.72845" y="6861.647"/> </glyph> <glyph class="macromolecule" id="s2694_sa1213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 3, 34kDa HUGO:GTF2H3, HGNC:4657, ENTREZ:2967, UNIPROT:Q13889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH3*"/> <bbox w="80.0" h="40.0" x="699.72845" y="6903.647"/> </glyph> <glyph class="macromolecule" id="s2695_sa1214"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 4, 52kDa HUGO:GTF2H4, HGNC:4658, ENTREZ:2968, UNIPROT:Q92759 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH4*"/> <bbox w="80.0" h="40.0" x="699.72845" y="6945.647"/> </glyph> <glyph class="macromolecule" id="s2700_sa1216"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) HUGO:MNAT1 , HGNC:7181, ENTREZ:4331, UNIPROT:P51948 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G,PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="MNAT1"/> <bbox w="80.0" h="40.0" x="615.35657" y="6944.647"/> </glyph> <glyph class="macromolecule" id="s2701_sa1217"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 7 HUGO:CDK7, HGNC:1778, ENTREZ:1022, UNIPROT:P50613 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 CDK7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II References_end</body> </html> </notes> <label text="CDK7"/> <bbox w="80.0" h="40.0" x="615.35657" y="6985.647"/> </glyph> <glyph class="macromolecule" id="s2696_sa1218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CyclinH HUGO:CCNH, HGNC:1594, ENTREZ:902, UNIPROT:P51946 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery: PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="CyclinH*"/> <bbox w="80.0" h="40.0" x="697.72845" y="6987.647"/> </glyph> <glyph class="macromolecule" id="s2704_sa1219"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XPA binding protein 2 HUGO:XAB2, HGNC:14089, ENTREZ:56949, UNIPROT:Q9HCS7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XAB2"/> <bbox w="80.0" h="40.0" x="780.3177" y="6816.3613"/> </glyph> <glyph class="macromolecule" id="s2703_sa1220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group A HUGO:XPA, HGNC:12814, ENTREZ:7507, UNIPROT:P23025 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470 PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPA"/> <bbox w="80.0" h="40.0" x="781.13916" y="6858.9326"/> <glyph class="state variable" id="_0044d6a3-cc6d-4d84-a01b-b8801bcda233"> <state value="P" variable="S196"/> <bbox w="35.0" h="10.0" x="763.63916" y="6865.439"/> </glyph> </glyph> <glyph class="macromolecule" id="s2707_sa1221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="782.72845" y="6902.647"/> </glyph> <glyph class="macromolecule" id="s2705_sa1222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="781.3895" y="6945.441"/> <glyph class="state variable" id="_e8c0ce26-a8b7-42ad-85de-1597a5001859"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="773.8895" y="6960.441"/> </glyph> </glyph> <glyph class="macromolecule" id="s2706_sa1223"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="780.72845" y="6989.647"/> </glyph> </glyph> <glyph class="complex" id="s3027_csa6" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK7:CyclinH*:MNAT1:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XPB*:XPD* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="CDK7/CycH*/MNAT1/TFB5*/TFIIH1*/TFIIH2*/TFIIH3*/TFIIH4*/TTDA*/XPB*/XPD*"/> <bbox w="191.0" h="263.0" x="628.47217" y="6452.3564"/> <glyph class="macromolecule" id="s413_sa392"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 5 HUGO:GTF2H5, HGNC:21157, ENTREZ:404672, UNIPROT:Q6ZYL4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH5*"/> <bbox w="80.0" h="40.0" x="636.97217" y="6544.3564"/> </glyph> <glyph class="macromolecule" id="s847_sa393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 2 HUGO:ERCC2, HGNC:3434, ENTREZ:2068, UNIPROT:P18074 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPD*"/> <bbox w="80.0" h="40.0" x="636.97217" y="6505.1064"/> </glyph> <glyph class="macromolecule" id="s842_sa394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) HUGO:ERCC3, HGNC:3435, ENTREZ:2071, UNIPROT:P19447 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPB*"/> <bbox w="80.0" h="40.0" x="634.97217" y="6463.8564"/> </glyph> <glyph class="macromolecule" id="s852_sa395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 1, 62kDa HUGO:GTF2H1, HGNC:4655, ENTREZ:HGNC:2965, UNIPROT:P32780 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH1*"/> <bbox w="80.0" h="40.0" x="726.97217" y="6474.3564"/> </glyph> <glyph class="macromolecule" id="s858_sa396"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 2, 44kDa HUGO:GTF2H2, HGNC:4656, ENTREZ:2966, UNIPROT:Q13888 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH2*"/> <bbox w="80.0" h="40.0" x="726.97217" y="6517.6064"/> </glyph> <glyph class="macromolecule" id="s855_sa397"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 3, 34kDa HUGO:GTF2H3, HGNC:4657, ENTREZ:2967, UNIPROT:Q13889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH3*"/> <bbox w="80.0" h="40.0" x="725.97217" y="6560.8564"/> </glyph> <glyph class="macromolecule" id="s861_sa398"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: general transcription factor IIH, polypeptide 4, 52kDa HUGO:GTF2H4, HGNC:4658, ENTREZ:2968, UNIPROT:Q92759 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="TFIIH4*"/> <bbox w="80.0" h="40.0" x="726.97217" y="6604.1064"/> </glyph> <glyph class="macromolecule" id="s351_sa400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) HUGO:MNAT1 , HGNC:7181, ENTREZ:4331, UNIPROT:P51948 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G,PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="MNAT1"/> <bbox w="80.0" h="40.0" x="634.97217" y="6614.3564"/> </glyph> <glyph class="macromolecule" id="s352_sa401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 7 HUGO:CDK7, HGNC:1778, ENTREZ:1022, UNIPROT:P50613 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:DNA_REPAIR MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery PMID:19667075, PMID:7533895 CDK7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II References_end</body> </html> </notes> <label text="CDK7"/> <bbox w="80.0" h="40.0" x="633.97217" y="6652.3564"/> </glyph> <glyph class="macromolecule" id="s1898_sa402"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CyclinH HUGO:CCNH, HGNC:1594, ENTREZ:902, UNIPROT:P51946 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261 Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery: PMID:19667075, PMID:7533895 References_end</body> </html> </notes> <label text="CyclinH*"/> <bbox w="80.0" h="40.0" x="728.97217" y="6647.3564"/> </glyph> </glyph> <glyph class="complex" id="s1657_csa10" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CETN2:RAD23*:XPC Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="CETN2/RAD23*/XPC"/> <bbox w="122.0" h="169.0" x="1453.4722" y="6797.3564"/> <glyph class="macromolecule" id="s3390_sa423"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: xeroderma pigmentosum, complementation group C HUGO:XPC, HGNC:12816, ENTREZ:7508, UNIPROT:Q01831 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPC"/> <bbox w="80.0" h="40.0" x="1478.9722" y="6802.8564"/> </glyph> <glyph class="macromolecule" id="s831_sa424"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD23 homolog A (S. cerevisiae) HUGO:RAD23A, HGNC:9812, ENTREZ:5886, UNIPROT:P54725 RAD23 homolog B HUGO:RAD23B, HGNC:9813, ENTREZ:5887, UNIPROT:P54727 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="RAD23*"/> <bbox w="80.0" h="40.0" x="1473.9722" y="6847.8564"/> </glyph> <glyph class="macromolecule" id="s363_sa425"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Centrin, EF-hand protein, 2 HUGO:CETN2, HGNC:1867, ENTREZ:1069, UNIPROT:P41208 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CETN2"/> <bbox w="80.0" h="40.0" x="1471.9722" y="6888.8564"/> </glyph> </glyph> <glyph class="complex" id="s3200_csa12" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CHTF18:PCNA:POLD*:POLE*:POLK:RFC*:RPA1:RPA2:RPA3:XRCC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:21282463 References_end</body> </html> </notes> <label text="CHTF18/PCNA/POLD*/POLE*/POLK/RFC/RPA1/RPA2/RPA3/XRCC1"/> <bbox w="332.0" h="210.0" x="751.47217" y="7580.3564"/> <glyph class="macromolecule" id="s519_sa448"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="955.6487" y="7684.2036"/> <glyph class="state variable" id="_8ce8e6a7-77bf-4685-a9fe-652aee634a23"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="944.6325" y="7679.2036"/> </glyph> <glyph class="state variable" id="_d26f45a1-88b8-4efb-be18-51ed21598cea"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="940.6487" y="7699.2036"/> </glyph> <glyph class="state variable" id="_f1048ccb-c2ca-4d0f-94eb-1fbdc0d58286"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="974.08014" y="7719.2036"/> </glyph> <glyph class="state variable" id="_86d870e5-e702-4884-b10f-428f40e1ef73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="950.6487" y="7719.2036"/> </glyph> <glyph class="state variable" id="_ee8e0da1-cc92-47e2-961b-d7aff93a9db4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="990.6487" y="7719.2036"/> </glyph> </glyph> <glyph class="macromolecule" id="s521_sa449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication factor C (activator 1) 1, 145kDa HUGO:RFC1, HGNC:9969, ENTREZ:5981, UNIPROT:P35251 replication factor C (activator 1) 2, 40kDa HUGO:RFC2, HGNC:9970, ENTREZ:5982, UNIPROT:P35250 replication factor C (activator 1) 3, 38kDa HUGO:RFC3, HGNC:9971, ENTREZ:5983, UNIPROT:P40938 replication factor C (activator 1) 4, 37kDa HUGO:RFC4, HGNC:9972, ENTREZ:5984, UNIPROT:P35249 replication factor C (activator 1) 5, 36.5kDa HUGO:RFC5, HGNC:9973, ENTREZ:5985, UNIPROT:P40937 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="RFC*"/> <bbox w="80.0" h="40.0" x="861.1487" y="7675.7036"/> </glyph> <glyph class="macromolecule" id="s321_sa450"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), epsilon HUGO:POLE, HGNC:9177, ENTREZ:5426, UNIPROT:Q07864 polymerase (DNA directed), epsilon 2 (p59 subunit) HUGO:POLE2, HGNC:9178, ENTREZ:5427, UNIPROT:P56282 polymerase (DNA directed), epsilon 3 (p17 subunit) HUGO:POLE3, HGNC:13546, ENTREZ:54107, UNIPROT:Q9NRF9 polymerase (DNA-directed), epsilon 4 (p12 subunit) HUGO:POLE4, HGNC:18755, ENTREZ:56655, UNIPROT:Q9NR33 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="POLE*"/> <bbox w="80.0" h="40.0" x="763.1487" y="7692.7036"/> </glyph> <glyph class="macromolecule" id="s320_sa451"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), delta 1, catalytic subunit 125kDa HUGO:POLD1, HGNC:9175, ENTREZ:5424, UNIPROT:P28340 polymerase (DNA directed), delta 2, regulatory subunit 50kDa HUGO:POLD2, HGNC:9176, ENTREZ:5425, UNIPROT:P49005 polymerase (DNA-directed), delta 3, accessory subunit HUGO:POLD3, HGNC:20932, ENTREZ:10714, UNIPROT:Q15054 polymerase (DNA-directed), delta 4 HUGO:POLD4, HGNC:14106, ENTREZ:57804, UNIPROT:Q9HCU8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20478261 For A_NHEJ PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 References_end</body> </html> </notes> <label text="POLD*"/> <bbox w="80.0" h="40.0" x="761.6487" y="7642.2036"/> </glyph> <glyph class="macromolecule" id="s3149_sa1431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) HUGO:CHTF18, HGNC:18435, ENTREZ:63922, UNIPROT:Q8WVB6 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:12930902, PMID:20227374 References_end</body> </html> </notes> <label text="CHTF18"/> <bbox w="80.0" h="40.0" x="954.6655" y="7638.7803"/> </glyph> <glyph class="macromolecule" id="s3150_sa1432"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) kappa HUGO:POLK, HGNC:9183, ENTREZ:51426, UNIPROT:Q96Q87 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:NER Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to Y-family polymerases PMID:19258535 Bypasses benzo(a)pyrene (B(a)P) adducts on guanine (dG-n2-BPDE adducts) PMID:15189466 For NER pathway PMID:20227374 References_end</body> </html> </notes> <label text="POLK"/> <bbox w="80.0" h="40.0" x="858.444" y="7726.886"/> </glyph> <glyph class="macromolecule" id="s3151_sa1433"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="762.7449" y="7594.9336"/> <glyph class="state variable" id="_95948fe4-5b6b-44dd-9e2e-0aa9fd39937f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="811.8134" y="7589.9336"/> </glyph> </glyph> <glyph class="macromolecule" id="s3197_sa1476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="859.40076" y="7631.7847"/> </glyph> <glyph class="macromolecule" id="s3199_sa1477"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="956.0618" y="7594.579"/> <glyph class="state variable" id="_bd618007-71f1-4508-a2c3-a86e2c3ef909"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="948.5618" y="7609.579"/> </glyph> </glyph> <glyph class="macromolecule" id="s3198_sa1478"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="860.40076" y="7585.7847"/> </glyph> </glyph> <glyph class="complex" id="s2575_csa230" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CIP1_KIP1*:PARP1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="CIP/KIP*/PARP*"/> <bbox w="100.0" h="120.0" x="4609.472" y="29.356262"/> <glyph class="macromolecule" id="s2577_sa1174"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="81.0" h="40.0" x="4616.194" y="81.8149"/> <glyph class="state variable" id="_6c067e51-0f34-46d2-b040-4eef4d9084d1"> <state value="" variable="PolyADPribose"/> <bbox w="75.0" h="10.0" x="4614.7534" y="76.8149"/> </glyph> <glyph class="state variable" id="_e762b96a-b4db-4b7f-8f78-e53c0f0f945a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4692.194" y="96.8149"/> </glyph> <glyph class="state variable" id="_562b17b0-4df5-49a9-aac8-6c69d5e2d978"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="4605.1064" y="116.8149"/> </glyph> <glyph class="state variable" id="_44798329-59f9-4717-a90e-433fe3fd6f8b"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="4596.194" y="101.044464"/> </glyph> <glyph class="state variable" id="_8c60c680-d0b4-4054-877a-c088a9050332"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="4596.194" y="110.745926"/> </glyph> </glyph> <glyph class="macromolecule" id="s2576_sa1176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (p21, Cip1) HUGO:CDKN1A, HGNC:1784, ENTREZ:1026, UNIPROT:P38936 cyclin-dependent kinase inhibitor 1B (p27, Kip1) HUGO:CDKN1B, HGNC:1785, ENTREZ:1027, UNIPROT:P46527 cyclin-dependent kinase inhibitor 1C (p57, Kip2) HUGO:CDKN1C, HGNC:1786, ENTREZ:1028, UNIPROT:P49918 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CIP1_KIP1*"/> <bbox w="80.0" h="40.0" x="4620.1704" y="36.338253"/> </glyph> </glyph> <glyph class="complex" id="s397_csa14" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CSA*:CUL4*:DDB1:RBX1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="CSA*/CUL4*/DDB1/RBX1"/> <bbox w="172.0" h="114.0" x="268.47217" y="6661.3564"/> <glyph class="macromolecule" id="s406_sa456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring-box 1 HUGO:RBX1, HGNC:9928, ENTREZ:9978, UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:NER MODULE:FANCONI Maps_Modules_end References_begin: PMID:15459660 For NER pathway: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For Fanconi pathway: PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="352.97217" y="6673.8564"/> </glyph> <glyph class="macromolecule" id="s404_sa457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cullin 4A HUGO:CUL4A, HGNC:2554, ENTREZ:8451, UNIPROT:Q13619 Cullin 4B HUGO:CUL4B, HGNC:2555, ENTREZ:8450, UNIPROT:Q13620 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CUL4*"/> <bbox w="80.0" h="40.0" x="275.97217" y="6713.8564"/> <glyph class="state variable" id="_a256571e-500e-4a6a-89bd-0c3f4f981846"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="270.97217" y="6728.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2690_sa458"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 1, 127kDa, XPE, p48 HUGO:DDB1, HGNC:2717, ENTREZ:1642, UNIPROT:Q16531 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:1570337, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB1"/> <bbox w="80.0" h="40.0" x="357.97217" y="6710.8564"/> </glyph> <glyph class="macromolecule" id="s402_sa459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cockayne syndrome 1 (classical) excision repair cross-complementing rodent repair deficiency, complementation group 8 HUGO:ERCC8, HGNC:3439, ENTREZ:1161, UNIPROT:Q13216 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CSA*"/> <bbox w="80.0" h="40.0" x="276.49292" y="6674.012"/> </glyph> </glyph> <glyph class="complex" id="s330_csa13" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL4*:DDB1:DDB2:RBX1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="CUL4*/DDB1/DDB2/RBX1"/> <bbox w="168.0" h="111.0" x="1412.4722" y="6643.3564"/> <glyph class="macromolecule" id="s826_sa452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring-box 1 HUGO:RBX1, HGNC:9928, ENTREZ:9978, UNIPROT:P62877 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:NER MODULE:FANCONI Maps_Modules_end References_begin: PMID:15459660 For NER pathway: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For Fanconi pathway: PMID:19686080, PMID:19622404, PMID:18931676 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="1495.9722" y="6653.8564"/> </glyph> <glyph class="macromolecule" id="s827_sa453"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cullin 4A HUGO:CUL4A, HGNC:2554, ENTREZ:8451, UNIPROT:Q13619 Cullin 4B HUGO:CUL4B, HGNC:2555, ENTREZ:8450, UNIPROT:Q13620 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="CUL4*"/> <bbox w="80.0" h="40.0" x="1418.9722" y="6693.8564"/> <glyph class="state variable" id="_88e6ace7-8d42-497a-b6e3-9090c0c41e93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1413.9722" y="6708.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s828_sa454"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 1, 127kDa, XPE, p48 HUGO:DDB1, HGNC:2717, ENTREZ:1642, UNIPROT:Q16531 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:1570337, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB1"/> <bbox w="80.0" h="40.0" x="1496.9722" y="6692.8564"/> </glyph> <glyph class="macromolecule" id="s829_sa455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Damage-specific DNA binding protein 2, 48kDa HUGO:DDB2, HGNC:2718, ENTREZ:1643, UNIPROT:Q92466 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="DDB2"/> <bbox w="80.0" h="40.0" x="1417.9722" y="6653.8564"/> </glyph> </glyph> <glyph class="complex" id="s933_csa43" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:CTIP* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="CtBP*/CtIP*"/> <bbox w="105.0" h="123.0" x="6436.472" y="6589.3564"/> <glyph class="macromolecule" id="s3052_sa1410"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="6450.992" y="6600.219"/> <glyph class="state variable" id="_dc87479e-9389-4875-a55f-97afda65e689"> <state value="P" variable="S372"/> <bbox w="35.0" h="10.0" x="6457.0874" y="6595.219"/> </glyph> <glyph class="state variable" id="_ec87fd73-9ebe-40d7-87ed-9a1fadbe9bde"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6445.992" y="6615.219"/> </glyph> <glyph class="state variable" id="_9225b938-cbf9-45be-8d92-5f6cad3c387a"> <state value="P" variable="S267"/> <bbox w="35.0" h="10.0" x="6433.492" y="6625.591"/> </glyph> <glyph class="state variable" id="_0a7492cd-5b97-48be-b0cd-7a112f4257b8"> <state value="P" variable="T847"/> <bbox w="35.0" h="10.0" x="6433.492" y="6602.0703"/> </glyph> <glyph class="state variable" id="_9b8b5d8e-9e54-4038-abc1-8b74c83e3ce0"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="6454.861" y="6635.219"/> </glyph> </glyph> <glyph class="macromolecule" id="s3053_sa1411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1, HGNC:2494, ENTREZ:1487, UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2, HGNC:2495, ENTREZ:1488, UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21681822, PMID:20964627, PMID:19506021, PMID:19216735 References_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="6450.1235" y="6650.219"/> <glyph class="state variable" id="_ddec0248-6f03-4fab-98ec-1d087bf0bd30"> <state value="P" variable="S181"/> <bbox w="35.0" h="10.0" x="6483.5923" y="6645.219"/> </glyph> <glyph class="state variable" id="_b0a5cc03-0795-458d-8cdf-e6dc82bf298d"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="6511.483" y="6645.219"/> </glyph> <glyph class="state variable" id="_93ba2ccf-8ae9-4658-b1f8-0757b04372bd"> <state value="P" variable="S185"/> <bbox w="35.0" h="10.0" x="6466.489" y="6645.219"/> </glyph> <glyph class="state variable" id="_277a25a6-abde-4d10-9710-cc51d98d9c81"> <state value="P" variable="T179"/> <bbox w="35.0" h="10.0" x="6451.272" y="6645.219"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3224_csa44" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:CTIP*:RB1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="CtBP*/CtIP*/RB1"/> <bbox w="106.0" h="171.0" x="4438.472" y="3585.3562"/> <glyph class="macromolecule" id="s3055_sa1412"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="4451.368" y="3597.945"/> <glyph class="state variable" id="_5bf73687-4fa2-45ea-a683-de3bb0d21d60"> <state value="P" variable="S372"/> <bbox w="35.0" h="10.0" x="4457.4634" y="3592.945"/> </glyph> <glyph class="state variable" id="_2a411c4e-9a15-4a01-a2a1-d774f1daf05b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4446.368" y="3612.945"/> </glyph> <glyph class="state variable" id="_cd3b217f-bc4d-44b6-8ac3-c30cbd0c725a"> <state value="P" variable="S267"/> <bbox w="35.0" h="10.0" x="4433.868" y="3623.317"/> </glyph> <glyph class="state variable" id="_e347d380-b2de-44c3-afa1-96c3ad0d55d0"> <state value="P" variable="T847"/> <bbox w="35.0" h="10.0" x="4433.868" y="3599.7961"/> </glyph> <glyph class="state variable" id="_3686eef6-9052-42cb-a238-592158ca1236"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="4455.237" y="3632.945"/> </glyph> </glyph> <glyph class="macromolecule" id="s3054_sa1413"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1, HGNC:2494, ENTREZ:1487, UNIPROT:Q13363 C-terminal binding protein 2 HUGO:CTBP2, HGNC:2495, ENTREZ:1488, UNIPROT:P56545 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:21681822, PMID:20964627, PMID:19506021, PMID:19216735 References_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="4450.4995" y="3647.945"/> <glyph class="state variable" id="_d8769e71-a523-4bd0-b852-9f9eee463606"> <state value="P" variable="S181"/> <bbox w="35.0" h="10.0" x="4483.9683" y="3642.945"/> </glyph> <glyph class="state variable" id="_60ecf277-728b-4b81-bff4-7662bd06ea50"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="4511.859" y="3642.945"/> </glyph> <glyph class="state variable" id="_38d43ba8-4e25-4772-8ab5-771bdaaa55da"> <state value="P" variable="S185"/> <bbox w="35.0" h="10.0" x="4466.8647" y="3642.945"/> </glyph> <glyph class="state variable" id="_1c04c6ba-82ff-4e06-980a-c1c461f56d86"> <state value="P" variable="T179"/> <bbox w="35.0" h="10.0" x="4451.648" y="3642.945"/> </glyph> </glyph> <glyph class="macromolecule" id="s3223_sa1486"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma 1 HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440 References_end</body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="4453.0176" y="3693.3562"/> <glyph class="state variable" id="_44f97742-2369-41ad-a1af-1925a2e5734d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4528.0176" y="3708.3562"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1491_csa91" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTIP*:PCNA Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex CtIP*/PCNA PMID:19342888 References_end</body> </html> </notes> <label text="CtIP*/PCNA"/> <bbox w="100.0" h="120.0" x="5126.472" y="3636.3562"/> <glyph class="macromolecule" id="s1492_sa719"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="5138.829" y="3692.0706"/> <glyph class="state variable" id="_23a062ee-0001-4aee-ad72-d329948c2164"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="5127.813" y="3687.0706"/> </glyph> <glyph class="state variable" id="_569fcc6c-14c5-4338-ab0b-4e6c872dbde4"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="5123.829" y="3707.0706"/> </glyph> <glyph class="state variable" id="_0971f9cd-7575-497b-a9f6-941c66ccef19"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5157.2607" y="3727.0706"/> </glyph> <glyph class="state variable" id="_22f3a7b8-7074-4327-bbcb-7b614f4c877d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5133.829" y="3727.0706"/> </glyph> <glyph class="state variable" id="_20d4687e-af64-4704-b477-0702024078b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5173.829" y="3727.0706"/> </glyph> </glyph> <glyph class="macromolecule" id="s2538_sa1159"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 8 (RIM) CTBP-interacting protein (CtIP) HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="CTIP*"/> <bbox w="80.0" h="40.0" x="5137.278" y="3646.8264"/> <glyph class="state variable" id="_a96c2e5b-1e83-45a7-bcde-aed79fa02e16"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="5145.873" y="3641.8264"/> </glyph> <glyph class="state variable" id="_a42696cf-99e2-4c7d-a502-35d93d865cc6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5132.278" y="3661.8264"/> </glyph> <glyph class="state variable" id="_c760f2d6-6c88-40b9-8db3-74704e3887a3"> <state value="" variable="S267"/> <bbox w="30.0" h="10.0" x="5122.278" y="3672.1982"/> </glyph> <glyph class="state variable" id="_a63c5f93-f1d3-48be-8528-c7cb304e375c"> <state value="" variable="T847"/> <bbox w="30.0" h="10.0" x="5122.278" y="3648.6775"/> </glyph> <glyph class="state variable" id="_af92dd75-9427-4d79-8996-e712697da1be"> <state value="" variable="BRCA1-dep"/> <bbox w="55.0" h="10.0" x="5141.1465" y="3681.8264"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3418_csa273" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DNA-PK*:Ku70*:Ku80*:WRN Identifiers_end References_begin: PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 References_end</body> </html> </notes> <label text="DNA-PK*/Ku70*/Ku80*/WRN"/> <bbox w="192.0" h="120.0" x="5867.472" y="6750.3564"/> <glyph class="macromolecule" id="s3416_sa1595"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="5965.296" y="6802.2974"/> <glyph class="state variable" id="_2980251a-cb93-467e-ba6e-5540932fc00c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5999.0435" y="6797.2974"/> </glyph> </glyph> <glyph class="macromolecule" id="s3415_sa1602"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="5880.0107" y="6759.2793"/> </glyph> <glyph class="macromolecule" id="s3411_sa1603"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <bbox w="80.0" h="40.0" x="5879.0107" y="6804.2793"/> <glyph class="state variable" id="_ef74daa4-e816-483d-892d-1d7b7c3c9693"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5897.4424" y="6799.2793"/> </glyph> </glyph> <glyph class="macromolecule" id="s3417_sa1606"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <bbox w="80.0" h="40.0" x="5965.347" y="6758.1064"/> <glyph class="state variable" id="_4b0c58d2-cde0-4345-944e-1fd8736baa79"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5960.347" y="6773.1064"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s396_csa7" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TC-NER_DNA_st1*:Transcription machine_br_ Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: UV light causes bulky adducts damage in DNA that repared by NER pathway PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527 Transcription-dependent NER and damage by UV PMID:20045328, PMID:14599741 Interstrand crosslinking agents induce NER PMID:21701511 References_end</body> </html> </notes> <label text="DNA/transcription machine"/> <bbox w="215.0" h="102.0" x="76.47217" y="6531.3564"/> <glyph class="nucleic acid feature" id="s1680_sa403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TC-NER:DNA st1 Transcriptionaly-active chemically or structurally damaged DNA coupled to transcription machinery Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end References_begin: PMID:23892398 PMID:20211143 PMID:22258607, PMID:22918414 PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 UV light causes bulky adducts damage in DNA that repared by NER pathway PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527 Transcription-dependent NER and damage by UV PMID:20045328, PMID:14599741 Interstrand crosslinking agents induce NER PMID:21701511 References_end</body> </html> </notes> <label text="TC-NER_DNA_st1*"/> <bbox w="170.0" h="26.0" x="105.47217" y="6585.8564"/> </glyph> <glyph class="macromolecule" id="s3033_sa1190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Transcription complex Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="Transcription machine (RNAPII)*"/> <bbox w="123.0" h="40.0" x="130.97217" y="6543.8564"/> <glyph class="state variable" id="_15079dd9-c9c0-41a2-90d4-0c36786c4318"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="125.97217" y="6559.625"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3065_csa266" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRIT1*:E2F1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: BRIT1*/E2F1 complex activates BRCA1 and CHEK1 transcription during S-phase and G2/M checkpoints PMID:15220350, PMID:18660752 References_end</body> </html> </notes> <label text="E2F1/BRIT1*"/> <bbox w="100.0" h="120.0" x="6407.472" y="2152.3562"/> <glyph class="macromolecule" id="s3066_sa1420"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1, HGNC:3113, ENTREZ:1869, UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="6416.472" y="2161.3562"/> <glyph class="state variable" id="_1ac04973-9e11-4dbd-965f-178bd8bb0e1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6491.472" y="2176.3562"/> </glyph> </glyph> <glyph class="macromolecule" id="s3067_sa1423"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCT-repeat inhibitor of TERT expression 1 (BRIT1), Microcephalin(MCPH1) HUGO:MCPH1, HGNC:6954, ENTREZ:79648, UNIPROT:Q8NEM0 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:20376879, PMID:15220350, PMID:19525936, PMID:18660752 References_end</body> </html> </notes> <label text="BRIT1*"/> <bbox w="80.0" h="40.0" x="6415.472" y="2207.3562"/> </glyph> </glyph> <glyph class="complex" id="s3343_csa105" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E2F1:RB1 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="E2F1/RB1"/> <bbox w="105.0" h="115.0" x="4785.472" y="878.35626"/> <glyph class="macromolecule" id="s3344_sa756"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1, HGNC:3113, ENTREZ:1869, UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="4795.472" y="884.35626"/> <glyph class="state variable" id="_d8d986a9-fef6-4739-9b74-bef80b719b46"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4870.472" y="899.35626"/> </glyph> </glyph> <glyph class="macromolecule" id="s1810_sa757"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma 1 HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440 References_end</body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="4795.472" y="926.35626"/> <glyph class="state variable" id="_05686b2d-0874-4ebe-bef1-1a4afb202a98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4870.472" y="941.35626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3081_csa107" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E2F1:RB1 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="E2F1/RB1"/> <bbox w="95.0" h="113.0" x="4997.472" y="877.35626"/> <glyph class="macromolecule" id="s3082_sa761"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1, HGNC:3113, ENTREZ:1869, UNIPROT:Q01094 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="5001.472" y="884.35626"/> <glyph class="state variable" id="_fae3bfd8-4f21-46c8-8f3c-ca715f3a67ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5076.472" y="899.35626"/> </glyph> </glyph> <glyph class="macromolecule" id="s24_sa762"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma 1 HUGO:RB1, HGNC:9884, ENTREZ:5925, UNIPROT:P06400 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440 References_end</body> </html> </notes> <label text="RB1"/> <bbox w="80.0" h="40.0" x="5003.472" y="926.35626"/> <glyph class="state variable" id="_81211e11-3528-4898-91cf-23717c2b020a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5075.972" y="941.35626"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2150_csa118" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E2F4_5*:p107* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="E2F4,5*/p107*"/> <bbox w="90.0" h="110.0" x="4616.472" y="535.35626"/> <glyph class="macromolecule" id="s2151_sa785"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 4, p107/p130-binding HUGO:E2F4, HGNC:3118, ENTREZ:1874, UNIPROT:Q16254 E2F transcription factor 5, p130-binding HUGO:E2F5, HGNC:3119, ENTREZ:1875, UNIPROT:Q15329 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F4_5*"/> <bbox w="80.0" h="40.0" x="4621.472" y="539.35626"/> </glyph> <glyph class="macromolecule" id="s103_sa786"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma-like 1 (p107) HUGO:RBL1, HGNC:9893, ENTREZ:5933, UNIPROT:P28749 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="p107*"/> <bbox w="80.0" h="40.0" x="4620.472" y="578.85626"/> <glyph class="state variable" id="_16d9f760-3d4a-40f4-922c-accda0ce273d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4695.472" y="590.2699"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3115_csa115" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E2F4_5*:p107* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="E2F4/p107*"/> <bbox w="93.0" h="110.0" x="4783.472" y="525.35626"/> <glyph class="macromolecule" id="s3116_sa778"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 4, p107/p130-binding HUGO:E2F4, HGNC:3118, ENTREZ:1874, UNIPROT:Q16254 E2F transcription factor 5, p130-binding HUGO:E2F5, HGNC:3119, ENTREZ:1875, UNIPROT:Q15329 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="E2F4_5*"/> <bbox w="80.0" h="40.0" x="4789.472" y="529.35626"/> </glyph> <glyph class="macromolecule" id="s1907_sa779"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma-like 1 (p107) HUGO:RBL1, HGNC:9893, ENTREZ:5933, UNIPROT:P28749 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="p107*"/> <bbox w="80.0" h="40.0" x="4789.472" y="568.85626"/> <glyph class="state variable" id="_fd91c5a4-beda-4a80-8f78-cc604fe79701"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4861.972" y="580.2699"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1412_csa63" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EME1:MSH2:MSH3:MUS81:SNM1B* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="EME1/MSH2/MSH3/MUS81/SNM1B*"/> <bbox w="198.0" h="165.0" x="8554.473" y="6984.3564"/> <glyph class="macromolecule" id="s2776_sa647"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: essential meiotic endonuclease 1 homolog 1 (S. pombe) HUGO:EME1, HGNC:24965, ENTREZ:146956, UNIPROT:Q96AY2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="EME1"/> <bbox w="80.0" h="40.0" x="8659.391" y="7036.331"/> </glyph> <glyph class="macromolecule" id="s2777_sa648"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MUS81 endonuclease homolog (S. cerevisiae) HUGO:MUS81, HGNC:29814, ENTREZ:80198, UNIPROT:Q96NY9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258, PMID:22101340 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MUS81"/> <bbox w="80.0" h="40.0" x="8661.391" y="7081.331"/> </glyph> <glyph class="macromolecule" id="s2778_sa649"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1B, HGNC:17641, ENTREZ:64858, UNIPROT:Q9H816 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20655466, PMID:18469862 References_end</body> </html> </notes> <label text="SNM1B*"/> <bbox w="80.0" h="40.0" x="8658.115" y="6992.2134"/> </glyph> <glyph class="macromolecule" id="s2773_sa650"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 3 (E. coli) HUGO:MSH3, HGNC:7326, ENTREZ:4437, UNIPROT:P20585 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:SSA Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH3"/> <bbox w="80.0" h="40.0" x="8571.973" y="7033.3564"/> </glyph> <glyph class="macromolecule" id="s2774_sa651"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="8572.473" y="6992.3564"/> <glyph class="state variable" id="_e325c50a-1ae4-44c9-be4b-ce012b086ecb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8567.473" y="7007.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1605_csa95" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EME1:MUS81:SLX4* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="EME1/MUS81/SLX4*"/> <bbox w="119.0" h="162.0" x="4848.472" y="7614.3564"/> <glyph class="macromolecule" id="s1594_sa730"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MUS81 endonuclease homolog (S. cerevisiae) HUGO:MUS81, HGNC:29814, ENTREZ:80198, UNIPROT:Q96NY9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258, PMID:22101340 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MUS81"/> <bbox w="80.0" h="40.0" x="4867.329" y="7624.499"/> </glyph> <glyph class="macromolecule" id="s1595_sa731"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: essential meiotic endonuclease 1 homolog 1 (S. pombe) HUGO:EME1, HGNC:24965, ENTREZ:146956, UNIPROT:Q96AY2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="EME1"/> <bbox w="80.0" h="40.0" x="4868.329" y="7668.499"/> </glyph> <glyph class="macromolecule" id="s1604_sa732"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BTB (POZ) domain containing 12 Structure-specific endonuclease subunit SLX4 HUGO:BTBD12, HGNC:23845, ENTREZ:84464, UNIPROT:Q8IY92 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236, PMID:22101340 References_end</body> </html> </notes> <label text="SLX4*"/> <bbox w="80.0" h="40.0" x="4868.901" y="7711.3564"/> </glyph> </glyph> <glyph class="complex" id="s1407_csa58" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EME1:MUS81:SNM1B* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="EME1/MUS81/SNM1B*"/> <bbox w="123.0" h="166.0" x="7155.472" y="8222.356"/> <glyph class="macromolecule" id="s1067_sa626"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: essential meiotic endonuclease 1 homolog 1 (S. pombe) HUGO:EME1, HGNC:24965, ENTREZ:146956, UNIPROT:Q96AY2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: For HR pathway PMID:19772495, PMID:16697054, PMID:19847258 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="EME1"/> <bbox w="80.0" h="40.0" x="7185.748" y="8278.474"/> </glyph> <glyph class="macromolecule" id="s1066_sa627"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MUS81 endonuclease homolog (S. cerevisiae) HUGO:MUS81, HGNC:29814, ENTREZ:80198, UNIPROT:Q96NY9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258, PMID:22101340 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MUS81"/> <bbox w="80.0" h="40.0" x="7187.748" y="8320.474"/> </glyph> <glyph class="macromolecule" id="s1406_sa628"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HUGO:DCLRE1B, HGNC:17641, ENTREZ:64858, UNIPROT:Q9H816 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20655466, PMID:18469862 References_end</body> </html> </notes> <label text="SNM1B*"/> <bbox w="80.0" h="40.0" x="7187.472" y="8233.356"/> </glyph> </glyph> <glyph class="complex" id="s1392_csa23" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERCC1:MLH1:PMS2:XPF* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="ERCC1/PMS2/MLH1/XPF*"/> <bbox w="191.0" h="114.0" x="8562.473" y="6850.3564"/> <glyph class="macromolecule" id="s2771_sa479"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) HUGO:ERCC1, HGNC:3433, ENTREZ:2067, UNIPROT:P07992 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G, PMID:11900249 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="ERCC1"/> <bbox w="80.0" h="40.0" x="8656.473" y="6857.8564"/> </glyph> <glyph class="macromolecule" id="s2770_sa480"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 4 HUGO:ERCC4, HGNC:3436, ENTREZ:2072, UNIPROT:Q92889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:22101340, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For Fanconi pathway PMID:19686080 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XPF*"/> <bbox w="80.0" h="40.0" x="8656.473" y="6896.8564"/> </glyph> <glyph class="macromolecule" id="s2768_sa481"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="8573.973" y="6857.3564"/> </glyph> <glyph class="macromolecule" id="s2767_sa482"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PMS1 postmeiotic segregation increased 2 (S. cerevisiae) HUGO:PMS2, HGNC:9122, ENTREZ:5395, UNIPROT:P54278 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="PMS2"/> <bbox w="80.0" h="40.0" x="8573.973" y="6899.3564"/> </glyph> </glyph> <glyph class="complex" id="s1606_csa97" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERCC1:SLX4*:XPF* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="ERCC1/SLX4/XPF*"/> <bbox w="121.0" h="157.0" x="4846.472" y="7447.3564"/> <glyph class="macromolecule" id="s1610_sa735"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BTB (POZ) domain containing 12 Structure-specific endonuclease subunit SLX4 HUGO:BTBD12, HGNC:23845, ENTREZ:84464, UNIPROT:Q8IY92 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236, PMID:22101340 References_end</body> </html> </notes> <label text="SLX4*"/> <bbox w="80.0" h="40.0" x="4865.722" y="7540.9395"/> </glyph> <glyph class="macromolecule" id="s2785_sa736"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) HUGO:ERCC1, HGNC:3433, ENTREZ:2067, UNIPROT:P07992 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G, PMID:11900249 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="ERCC1"/> <bbox w="80.0" h="40.0" x="4868.722" y="7454.4395"/> </glyph> <glyph class="macromolecule" id="s2784_sa737"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 4 HUGO:ERCC4, HGNC:3436, ENTREZ:2072, UNIPROT:Q92889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:22101340, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For Fanconi pathway PMID:19686080 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XPF*"/> <bbox w="80.0" h="40.0" x="4867.722" y="7499.4395"/> </glyph> </glyph> <glyph class="complex" id="s987_csa21" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERCC1:XPF* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ MODULE:FANCONI Maps_Modules_end References_begin: For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="ERCC1/XPF*"/> <bbox w="100.0" h="120.0" x="6495.472" y="7107.3564"/> <glyph class="macromolecule" id="s988_sa474"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) HUGO:ERCC1, HGNC:3433, ENTREZ:2067, UNIPROT:P07992 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI MODULE:SSA Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G, PMID:11900249 For Fanconi pathway PMID:19686080 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="ERCC1"/> <bbox w="80.0" h="40.0" x="6504.472" y="7114.8564"/> </glyph> <glyph class="macromolecule" id="s989_sa475"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 4 HUGO:ERCC4, HGNC:3436, ENTREZ:2072, UNIPROT:Q92889 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:A_NHEJ MODULE:FANCONI Maps_Modules_end References_begin: PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761 PMID:22101340, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For SSA pathway PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 For Fanconi pathway PMID:19686080 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XPF*"/> <bbox w="80.0" h="40.0" x="6507.472" y="7158.8564"/> </glyph> </glyph> <glyph class="complex" id="s664_csa2" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EXO1:PCNA:RFC*:RPA1:RPA2:RPA3:hMutL*:hMutS* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="EXO1/hMutL*/hMutS*/PCNA/RFC*/RPA1/RPA2/RPA3"/> <bbox w="288.0" h="171.0" x="3788.4722" y="6869.3564"/> <glyph class="macromolecule" id="s576_sa366"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication factor C (activator 1) 1, 145kDa HUGO:RFC1, HGNC:9969, ENTREZ:5981, UNIPROT:P35251 replication factor C (activator 1) 2, 40kDa HUGO:RFC2, HGNC:9970, ENTREZ:5982, UNIPROT:P35250 replication factor C (activator 1) 3, 38kDa HUGO:RFC3, HGNC:9971, ENTREZ:5983, UNIPROT:P40938 replication factor C (activator 1) 4, 37kDa HUGO:RFC4, HGNC:9972, ENTREZ:5984, UNIPROT:P35249 replication factor C (activator 1) 5, 36.5kDa HUGO:RFC5, HGNC:9973, ENTREZ:5985, UNIPROT:P40937 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="RFC*"/> <bbox w="80.0" h="40.0" x="3800.9722" y="6923.3564"/> </glyph> <glyph class="macromolecule" id="s577_sa367"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="3888.4722" y="6967.3564"/> <glyph class="state variable" id="_f9600d83-afcb-40d2-b615-14de10197631"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="3877.456" y="6962.3564"/> </glyph> <glyph class="state variable" id="_6e735536-3a85-4a48-aacc-afbba09b0426"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="3873.4722" y="6982.3564"/> </glyph> <glyph class="state variable" id="_aa73ad49-e02e-4421-b7d4-bd54a34669fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3906.9036" y="7002.3564"/> </glyph> <glyph class="state variable" id="_76f3612f-2560-4167-b497-7af5adf0a8cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3883.4722" y="7002.3564"/> </glyph> <glyph class="state variable" id="_be0bea2d-97d9-4e1f-a48d-4cfe3f7ee31f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3923.4722" y="7002.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s579_sa368"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: exonuclease 1 HUGO:EXO1, HGNC:3511, ENTREZ:9156, UNIPROT:Q9UQ84 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:14676842, PMID:15474417, PMID:18756267, PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:19490890, PMID:11438669, PMID:20019063, PMID:18048416 References_end</body> </html> </notes> <label text="EXO1"/> <bbox w="80.0" h="40.0" x="3889.8184" y="6919.769"/> <glyph class="state variable" id="_e1307a12-a73e-4faa-bfda-3f00eaa300d0"> <state value="" variable="S372"/> <bbox w="30.0" h="10.0" x="3874.8184" y="6951.038"/> </glyph> <glyph class="state variable" id="_be7ab77e-5090-4072-ace9-9db82fe757ea"> <state value="" variable="S692"/> <bbox w="30.0" h="10.0" x="3931.7676" y="6914.769"/> </glyph> <glyph class="state variable" id="_4ad6b9c0-e9dc-43f0-b4bf-747b61061cf9"> <state value="" variable="S587"/> <bbox w="30.0" h="10.0" x="3874.8184" y="6932.762"/> </glyph> <glyph class="state variable" id="_19e5928b-ed25-4cd5-a574-858355e0b7d9"> <state value="" variable="S567"/> <bbox w="30.0" h="10.0" x="3874.8184" y="6918.775"/> </glyph> </glyph> <glyph class="macromolecule" id="s2741_sa369"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="3973.8357" y="6878.9224"/> </glyph> <glyph class="macromolecule" id="s2739_sa370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="3977.8357" y="6962.9224"/> </glyph> <glyph class="macromolecule" id="s2740_sa371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="3975.3535" y="6921.58"/> <glyph class="state variable" id="_0cd6f409-8079-4825-893d-427142112cc3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3970.3535" y="6936.58"/> </glyph> </glyph> <glyph class="macromolecule" id="s2750_sa1253"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hMutL* Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="hMutL*"/> <bbox w="80.0" h="40.0" x="3800.5747" y="6877.497"/> </glyph> <glyph class="macromolecule" id="s2751_sa1254"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hMutS* Node_Type:Generic Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="hMutS*"/> <bbox w="80.0" h="40.0" x="3881.5747" y="6876.497"/> </glyph> </glyph> <glyph class="complex" id="s1158_csa65" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAAP100*:FANCB:FANCL Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="FAAP100/FANCB/FANCL"/> <bbox w="134.0" h="151.0" x="8978.473" y="7832.3564"/> <glyph class="macromolecule" id="s1161_sa655"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group B HUGO:FANCB, HGNC:3583, ENTREZ:2187, UNIPROT:Q8NB91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCB"/> <bbox w="80.0" h="40.0" x="9012.404" y="7841.052"/> </glyph> <glyph class="macromolecule" id="s1160_sa656"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group L HUGO:FANCL, HGNC:20748, ENTREZ:55120, UNIPROT:Q9NW38 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: The enzyme possesses E3 ubiquitin ligase activity, the active part in the Fanconi core complex PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCL"/> <bbox w="80.0" h="40.0" x="9013.404" y="7882.052"/> </glyph> <glyph class="macromolecule" id="s1159_sa657"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: some 17 open reading frame 70, FAAP100 HUGO:C17orf70, HGNC:26171, ENTREZ:80233, UNIPROT:Q0VG06 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP100*"/> <bbox w="80.0" h="40.0" x="9012.404" y="7922.052"/> </glyph> </glyph> <glyph class="complex" id="s1100_csa66" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FAAP24*:FANCM Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex, function is damage recognition PMID:19622404 References_end</body> </html> </notes> <label text="FAAP24*/FANCM"/> <bbox w="100.0" h="120.0" x="8589.473" y="6423.3564"/> <glyph class="macromolecule" id="s1103_sa658"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromosome 19 open reading frame 40, "Fanconi anemia-associated protein, 24 kDa" HUGO:C19orf40, HGNC:28467, ENTREZ:91442, UNIPROT:Q9BTP7 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FAAP24*"/> <bbox w="80.0" h="40.0" x="8600.881" y="6436.0317"/> </glyph> <glyph class="macromolecule" id="s1102_sa659"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group M HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:FANCONI MODULE:NER MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773 FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex PMID:19622404 HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase PMID:19282663, PMID:19622404 Link between Fanconi and NER PMID:22615860 Fanconi and cross-linking agents PMID:21948210 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCM"/> <bbox w="80.0" h="40.0" x="8600.881" y="6479.0317"/> <glyph class="state variable" id="_901a9805-58e4-4650-94c1-c1fae282c767"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8635.881" y="6474.0317"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1151_csa67" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FANCA:FANCG Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="FANCA/FANCG"/> <bbox w="100.0" h="120.0" x="9008.473" y="8003.3564"/> <glyph class="macromolecule" id="s1277_sa660"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group A HUGO:FANCA, HGNC:3582, ENTREZ:2175, UNIPROT:Q9UEL9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCA"/> <bbox w="80.0" h="40.0" x="9017.912" y="8014.8496"/> <glyph class="state variable" id="_4c849dfb-2195-4262-953e-bd7e98928ab7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9090.412" y="8029.8496"/> </glyph> </glyph> <glyph class="macromolecule" id="s1287_sa661"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group G HUGO:FANCG, HGNC:3588, UNIPROT:O15287 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCG"/> <bbox w="80.0" h="40.0" x="9017.482" y="8059.733"/> <glyph class="state variable" id="_b5540e7b-70f6-4fb7-abfb-6d2c2521eb96"> <state value="P" variable="S7"/> <bbox w="25.0" h="10.0" x="9028.577" y="8054.733"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1154_csa64" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FANCC:FANCE:FANCF Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="FANCC/FANCE/FANCF"/> <bbox w="127.0" h="151.0" x="8988.473" y="7662.3564"/> <glyph class="macromolecule" id="s1157_sa652"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group C HUGO:FANCC, HGNC:3584, ENTREZ:2176, UNIPROT:Q00597 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCC"/> <bbox w="80.0" h="40.0" x="9011.404" y="7670.828"/> </glyph> <glyph class="macromolecule" id="s1155_sa653"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group F HUGO:FANCF, HGNC:3587, ENTREZ:2188, UNIPROT:Q9NPI8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCF"/> <bbox w="80.0" h="40.0" x="9015.404" y="7750.828"/> </glyph> <glyph class="macromolecule" id="s1302_sa654"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group E HUGO:FANCE, HGNC:3586, ENTREZ:2178, UNIPROT:Q9HB96 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <label text="FANCE"/> <bbox w="80.0" h="40.0" x="9014.139" y="7712.416"/> <glyph class="state variable" id="_ce47b37f-38af-40f1-9cba-1e7882af2848"> <state value="P" variable="T346"/> <bbox w="35.0" h="10.0" x="8996.639" y="7727.3843"/> </glyph> <glyph class="state variable" id="_4e107f8a-dcd6-4642-95e2-94ee2bfc3ef7"> <state value="P" variable="S376"/> <bbox w="35.0" h="10.0" x="8996.639" y="7718.9224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1186_csa69" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FANCD2:FANCI Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="FANCD2/FANCI"/> <bbox w="100.0" h="120.0" x="8873.473" y="7418.3564"/> <glyph class="macromolecule" id="s1188_sa667"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="8883.615" y="7470.0703"/> <glyph class="state variable" id="_129d86d5-db79-4048-8684-be6c15fffa7e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8956.115" y="7505.0703"/> </glyph> <glyph class="state variable" id="_1af85a47-a368-4d23-8ff1-490c65d227d4"> <state value="Ub" variable="K523"/> <bbox w="40.0" h="10.0" x="8902.319" y="7505.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s1281_sa668"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="8882.336" y="7424.9077"/> <glyph class="state variable" id="_b0d6e7ca-ce1b-45a3-9687-62f560e6b2af"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8874.836" y="7431.6235"/> </glyph> <glyph class="state variable" id="_060897e9-16bf-4f31-b641-07b9061c9e24"> <state value="Ub" variable="K561"/> <bbox w="40.0" h="10.0" x="8902.24" y="7459.9077"/> </glyph> <glyph class="state variable" id="_0ae67c72-b195-4bc1-93d0-e78014b41f56"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="8908.168" y="7419.9077"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1424_csa89" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FANCD2:FANCI:POLN Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PolN:FANCD2:FANCI complex activate HR PMID:16337602 References_end</body> </html> </notes> <label text="FANCD2/FANCI/POLN"/> <bbox w="125.0" h="160.0" x="8636.473" y="7520.3564"/> <glyph class="macromolecule" id="s1427_sa713"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) nu HUGO:POLN, HGNC:18870, ENTREZ:353497, UNIPROT:Q7Z5Q5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR PMID:19772495, PMID:16697054, PMID:19847258 For A_NHEJ PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 Complex PolN:HEL308 participates in HR and in Fanconi pathways PMID:19995904 References_end</body> </html> </notes> <label text="POLN"/> <bbox w="80.0" h="40.0" x="8659.187" y="7618.3564"/> </glyph> <glyph class="macromolecule" id="s2819_sa714"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group I HUGO:FANCI, HGNC:25568, ENTREZ:55215, UNIPROT:Q9NVI1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22101340 References_end</body> </html> </notes> <label text="FANCI"/> <bbox w="80.0" h="40.0" x="8658.615" y="7572.0703"/> <glyph class="state variable" id="_68581ff0-ac06-41ed-98e9-98103fa67e5d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8731.115" y="7607.0703"/> </glyph> <glyph class="state variable" id="_6c3a385f-e27a-40cb-a533-49fbd44a419b"> <state value="Ub" variable="K523"/> <bbox w="40.0" h="10.0" x="8677.319" y="7607.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s2818_sa715"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fanconi anemia, complementation group D2 HUGO:FANCD2, HGNC:3585, ENTREZ:2177, UNIPROT:Q9BXW9 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676, PMID:22751496, PMID:23444773, PMID:20723763 References_end</body> </html> </notes> <label text="FANCD2"/> <bbox w="80.0" h="40.0" x="8659.336" y="7527.9077"/> <glyph class="state variable" id="_a1670fcf-0cb6-478e-bdb0-9cd1730e4c45"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8651.836" y="7534.6235"/> </glyph> <glyph class="state variable" id="_c595c452-7531-434d-b965-de53ad3780dd"> <state value="Ub" variable="K561"/> <bbox w="40.0" h="10.0" x="8679.24" y="7562.9077"/> </glyph> <glyph class="state variable" id="_9fd8e599-1a09-4684-86fe-8992f8f36b8d"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="8685.168" y="7522.9077"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1643_csa84" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FANCJ*:MLH1:PMS2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:FANCONI Maps_Modules_end References_begin: 17581638 Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism 20173781 References_end</body> </html> </notes> <label text="FANCJ*/MLH1/PMS2"/> <bbox w="122.0" h="155.0" x="8630.473" y="7162.3564"/> <glyph class="macromolecule" id="s1647_sa704"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 interacting protein C-terminal helicase 1, BACH1, FANCJ HUGO:BRIP1, HGNC:20473, ENTREZ:83990, UNIPROT:Q9BX63 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:TLS MODULE:FANCONI Maps_Modules_end References_begin: PMID:19686080, PMID:19622404, PMID:18931676 Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism PMID:20173781 References_end</body> </html> </notes> <label text="FANCJ*"/> <bbox w="80.0" h="40.0" x="8654.973" y="7255.8564"/> <glyph class="state variable" id="_82b1db5e-b6ad-468c-b382-07cd096f57c2"> <state value="" variable="S990"/> <bbox w="30.0" h="10.0" x="8680.005" y="7250.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2853_sa705"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="8652.473" y="7167.8564"/> </glyph> <glyph class="macromolecule" id="s2852_sa706"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PMS1 postmeiotic segregation increased 2 (S. cerevisiae) HUGO:PMS2, HGNC:9122, ENTREZ:5395, UNIPROT:P54278 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="PMS2"/> <bbox w="80.0" h="40.0" x="8653.473" y="7213.8564"/> </glyph> </glyph> <glyph class="complex" id="s3173_csa62" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FEN1:PCNA:WRN Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 References_end</body> </html> </notes> <label text="FEN1/PCNA/WRN"/> <bbox w="126.0" h="178.0" x="3116.4722" y="7452.3564"/> <glyph class="macromolecule" id="s104_sa644"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: flap structure-specific endonuclease 1 HUGO:FEN1, HGNC:3650, ENTREZ:2237, UNIPROT:P39748 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:23161013 References_end</body> </html> </notes> <label text="FEN1"/> <bbox w="80.0" h="40.0" x="3139.7222" y="7523.6064"/> </glyph> <glyph class="macromolecule" id="s3020_sa646"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="3142.7222" y="7566.8564"/> <glyph class="state variable" id="_7989d21c-cc0f-4aaa-b90c-b88d6e210426"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="3131.706" y="7561.8564"/> </glyph> <glyph class="state variable" id="_7cc2b2f3-bb36-44e1-8a98-ebf397c8c62a"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="3127.7222" y="7581.8564"/> </glyph> <glyph class="state variable" id="_132d29ae-369f-4476-b163-47014c867ec7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3161.1536" y="7601.8564"/> </glyph> <glyph class="state variable" id="_7bcd2de9-3610-4283-9b07-90a62e6fc565"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3137.7222" y="7601.8564"/> </glyph> <glyph class="state variable" id="_e9694c2b-55ba-43c9-96cd-abfdcc0b6dd4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3177.7222" y="7601.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s3172_sa1457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="3135.72" y="7473.773"/> <glyph class="state variable" id="_c68a846e-eddc-4a7d-9ed1-763f6fe35933"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3169.4678" y="7468.773"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1660_csa99" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GADD45A:PCNA Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:NER Maps_Modules_end References_begin: GADD45 interacts with PCNA and activates NER-only Global(GG-NER) 19652693, 10779360 References_end</body> </html> </notes> <label text="GADD45A/PCNA"/> <bbox w="100.0" h="120.0" x="1143.4722" y="6719.3564"/> <glyph class="macromolecule" id="s1662_sa741"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="1152.2579" y="6731.2134"/> <glyph class="state variable" id="_f251cbdd-e175-4d29-8464-067550c0bbea"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="1141.2418" y="6726.2134"/> </glyph> <glyph class="state variable" id="_e1bceff3-7d93-471b-9470-1500b90ae545"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="1137.2579" y="6746.2134"/> </glyph> <glyph class="state variable" id="_5cdb8230-0603-4685-8c3b-96b5bd1b959c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1170.6893" y="6766.2134"/> </glyph> <glyph class="state variable" id="_b5b040ff-674a-4592-bded-fad85874add4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1147.2579" y="6766.2134"/> </glyph> <glyph class="state variable" id="_4f31928e-93ae-4fa2-bd57-6f3bce78f21a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1187.2579" y="6766.2134"/> </glyph> </glyph> <glyph class="macromolecule" id="s1661_sa742"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Growth arrest and DNA-damage-inducible, alpha HUGO:GADD45A, HGNC:4095, ENTREZ:1647, UNIPROT:P24522 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19004803 CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest PMID:12124778, PMID:19652693, PMID:15917306 Role in BER PMID:23485469 References_end</body> </html> </notes> <label text="GADD45A"/> <bbox w="80.0" h="40.0" x="1152.7579" y="6772.2134"/> </glyph> </glyph> <glyph class="complex" id="s2961_csa256" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GINS1:GINS2:GINS3:GINS4 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="GINS1/GINS2/GINS3/GINS4"/> <bbox w="176.0" h="114.0" x="6397.472" y="532.35626"/> <glyph class="macromolecule" id="s2963_sa1342"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 1 (Psf1 homolog) HUGO:GINS1 HGNC:28980 ENTREZ:9837 UNIPROT:Q14691 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 1 (Psf1 homolog) PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS1"/> <bbox w="80.0" h="40.0" x="6401.472" y="543.35626"/> </glyph> <glyph class="macromolecule" id="s2964_sa1343"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 2 (Psf2 homolog) HUGO:GINS2 HGNC:24575 ENTREZ:51659 UNIPROT:Q9Y248 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 2 (Psf2 homolog) PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS2"/> <bbox w="80.0" h="40.0" x="6402.472" y="584.35626"/> </glyph> <glyph class="macromolecule" id="s2965_sa1344"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 3 (Psf3 homolog) HUGO:GINS3 HGNC:25851 ENTREZ:64785 UNIPROT:Q9BRX5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 3 (Psf3 homolog) CC phase:S PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS3"/> <bbox w="80.0" h="40.0" x="6486.472" y="543.35626"/> </glyph> <glyph class="macromolecule" id="s2962_sa1345"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GINS complex subunit 4 (Sld5 homolog) HUGO:GINS4 HGNC:28226 ENTREZ:84296 UNIPROT:Q9BRT9 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: GINS complex subunit 4 (Sld5 homolog) PMID:17417653, PMID:17652513, PMID:19223333, PMID:16531994 References_end</body> </html> </notes> <label text="GINS4"/> <bbox w="80.0" h="40.0" x="6488.472" y="585.35626"/> </glyph> </glyph> <glyph class="complex" id="s60_csa92" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:H2AFX:MDC1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:17303408, PMID:16377563 References_end</body> </html> </notes> <label text="H2AX*/MDC1"/> <bbox w="95.0" h="116.0" x="7088.472" y="6253.3564"/> <glyph class="macromolecule" id="s1483_sa720"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="7099.2217" y="6258.984"/> <glyph class="state variable" id="_4448bd38-b319-4660-adc0-2cbc3e8f6d99"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="7089.2217" y="6256.9165"/> </glyph> <glyph class="state variable" id="_f3f25522-5504-46b4-aa92-9821ad38867b"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7081.7217" y="6273.984"/> </glyph> </glyph> <glyph class="macromolecule" id="s3219_sa721"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1, HGNC:21163, ENTREZ:9656, UNIPROT:Q2TAZ4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:C_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890 References_end</body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="7099.0063" y="6302.8223"/> <glyph class="state variable" id="_859863ac-96f3-4495-989f-fd8bc431e095"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7091.5063" y="6317.7905"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2569_csa228" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:H2AFX:PARP1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="H2AX*/PARP*"/> <bbox w="100.0" h="120.0" x="4451.472" y="4141.3564"/> <glyph class="macromolecule" id="s2570_sa1168"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family, member X HUGO:H2AFX , HGNC:4739, ENTREZ:3014, UNIPROT:P16104 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:9488723, PMID:19772495, PMID:17303408 For S-phase checkpoint PMID:15459660, PMID:12607003 References_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="4466.472" y="4141.3564"/> <glyph class="state variable" id="_5fca46b2-1798-4c9e-a117-85a35c301ce6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4461.472" y="4139.289"/> </glyph> <glyph class="state variable" id="_2b00b2fa-c9ae-45a0-adc8-f2f0f067f7ac"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="4451.472" y="4156.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2571_sa1169"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="72.0" h="50.0" x="4460.471" y="4191.251"/> <glyph class="state variable" id="_6ab97c53-89fd-4de4-a1ca-1c689aac1be2"> <state value="" variable="PolyADPribose"/> <bbox w="72.0" h="10.0" x="4456.524" y="4186.251"/> </glyph> <glyph class="state variable" id="_76b8d966-5e14-4099-92b7-36df1a85120a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4527.471" y="4211.251"/> </glyph> <glyph class="state variable" id="_8f413a37-fa9e-4739-b633-f87f1c3f904d"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="4448.3936" y="4236.251"/> </glyph> <glyph class="state variable" id="_5c14fc5d-1d1a-4583-b0cb-96e3832e2e2d"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="4440.471" y="4216.538"/> </glyph> <glyph class="state variable" id="_bca9d833-2fa3-47f3-9341-01c28774af5d"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="4440.471" y="4228.6646"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1487_csa90" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HEL308*:POLQ Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end</body> </html> </notes> <label text="HEL308*/POLQ"/> <bbox w="94.0" h="109.0" x="8655.473" y="7397.3564"/> <glyph class="macromolecule" id="s1489_sa716"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), theta HUGO:POLQ, HGNC:9186, ENTREZ:10721, UNIPROT:O75417 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:FANCONI Maps_Modules_end References_begin: PMID:10395804, PMID:14576298, PMID:18503084, PMID:15496986 PMID:20624954, PMID:18472307 References_end</body> </html> </notes> <label text="POLQ"/> <bbox w="80.0" h="40.0" x="8663.044" y="7405.0703"/> </glyph> <glyph class="macromolecule" id="s1488_sa717"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: helicase, POLQ-like HUGO:HELQ, HGNC:18536, ENTREZ:113510, UNIPROT:Q8TDG4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20122407, PMID:20493853, PMID:21195035 References_end</body> </html> </notes> <label text="HEL308*"/> <bbox w="80.0" h="40.0" x="8664.329" y="7445.0703"/> </glyph> </glyph> <glyph class="complex" id="s3010_csa263" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HUS1:MUTH*:RAD1:RAD9* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: 9-1-1 complex stimulates MUTH and BER PMID:16879101 References_end</body> </html> </notes> <label text="HUS1/MUTH*/RAD1/RAD9*"/> <bbox w="176.0" h="108.0" x="1984.4722" y="7015.3564"/> <glyph class="macromolecule" id="s3011_sa1383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="2074.7192" y="7064.6265"/> <glyph class="state variable" id="_773a4fa3-8613-47ef-95f3-46ab92596f47"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2107.2192" y="7059.6265"/> </glyph> </glyph> <glyph class="macromolecule" id="s3012_sa1384"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD1 homolog (S. pombe) HUGO:RAD1, HGNC:9806, ENTREZ:5810, UNIPROT:O60671 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="RAD1"/> <bbox w="80.0" h="40.0" x="1993.1143" y="7020.2886"/> </glyph> <glyph class="macromolecule" id="s3013_sa1385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUS1 checkpoint homolog (S. pombe) HUGO:HUS1, HGNC:5309, ENTREZ:3364, UNIPROT:O60921 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:9524127, PMID:17493829 References_end</body> </html> </notes> <label text="HUS1"/> <bbox w="80.0" h="40.0" x="1992.1143" y="7064.2886"/> </glyph> <glyph class="macromolecule" id="s3401_sa1386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutY homolog (E. coli) HUGO:MUTYH, HGNC:7527, ENTREZ:4595, UNIPROT:Q9UIF7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:23507534 References_end</body> </html> </notes> <label text="MUTH*"/> <bbox w="80.0" h="40.0" x="2064.8643" y="7026.7886"/> </glyph> </glyph> <glyph class="complex" id="s3004_csa262" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HUS1:NEIL1:RAD1:RAD9* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: 9-1-1 complex stimulates NEIL1 glycosylase and BER PMID:17395641 References_end</body> </html> </notes> <label text="HUS1/NEIL1/RAD1/RAD9*"/> <bbox w="177.0" h="110.0" x="1971.4722" y="6653.3564"/> <glyph class="macromolecule" id="s3009_sa1379"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUS1 checkpoint homolog (S. pombe) HUGO:HUS1, HGNC:5309, ENTREZ:3364, UNIPROT:O60921 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:9524127, PMID:17493829 References_end</body> </html> </notes> <label text="HUS1"/> <bbox w="80.0" h="40.0" x="1979.6581" y="6703.352"/> </glyph> <glyph class="macromolecule" id="s3006_sa1380"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD1 homolog (S. pombe) HUGO:RAD1, HGNC:9806, ENTREZ:5810, UNIPROT:O60671 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="RAD1"/> <bbox w="80.0" h="40.0" x="2061.658" y="6660.352"/> </glyph> <glyph class="macromolecule" id="s3007_sa1381"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="2060.263" y="6702.69"/> <glyph class="state variable" id="_88cb3946-cd3f-4652-bfcb-4ebd843f61dd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2092.763" y="6697.69"/> </glyph> </glyph> <glyph class="macromolecule" id="s3008_sa1382"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nei like 1 (E. coli) HUGO:NEIL1, HGNC:18448, ENTREZ:79661, UNIPROT:Q96FI4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="NEIL1"/> <bbox w="80.0" h="40.0" x="1977.9309" y="6660.826"/> </glyph> </glyph> <glyph class="complex" id="s2908_csa245" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HUS1:RAD1:RAD9* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:BER Maps_Modules_end References_begin: 9-1-1 complex as part of S-phase checkpoint, stops replication PMID:15459660, PMID:17303408, PMID:19793801, PMID:17582221, PMID:18677104 9-1-1 complex activates Lig1 and BER PMID:15871698, PMID:16731526 9-1-1 complex activates FEN and BER PMID:15871698, PMID:16216273 9-1-1 complex activates TDG glycosylase and activates BER PMID:17855402 9-1-1 complex activates APE and BER PMID:17426133 References_end</body> </html> </notes> <label text="HUS1/RAD1/RAD9*"/> <bbox w="104.0" h="173.0" x="3150.4722" y="7024.3564"/> <glyph class="macromolecule" id="s2911_sa1300"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUS1 checkpoint homolog (S. pombe) HUGO:HUS1, HGNC:5309, ENTREZ:3364, UNIPROT:O60921 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:9524127, PMID:17493829 References_end</body> </html> </notes> <label text="HUS1"/> <bbox w="80.0" h="40.0" x="3161.1992" y="7131.3823"/> </glyph> <glyph class="macromolecule" id="s2910_sa1302"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD1 homolog (S. pombe) HUGO:RAD1, HGNC:9806, ENTREZ:5810, UNIPROT:O60671 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="RAD1"/> <bbox w="80.0" h="40.0" x="3163.1992" y="7041.3823"/> </glyph> <glyph class="macromolecule" id="s2930_sa1316"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="3161.8042" y="7086.72"/> <glyph class="state variable" id="_15cd2e7a-9f46-42df-8381-bafb0463c9c8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3194.3042" y="7081.72"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2919_csa247" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HUS1:RAD1:RAD17:RAD9*:RFC* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:17303408 References_end</body> </html> </notes> <label text="HUS1/RAD1/RAD9*/RAD17/RFC*"/> <bbox w="195.0" h="161.0" x="5402.472" y="4062.3562"/> <glyph class="macromolecule" id="s2916_sa1303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD17 homolog (S. pombe) HUGO:RAD17, HGNC:9807, ENTREZ:5884, UNIPROT:O75943 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:16885023, PMID:17303408 References_end</body> </html> </notes> <label text="RAD17"/> <bbox w="80.0" h="40.0" x="5499.632" y="4068.8352"/> <glyph class="state variable" id="_39dadcb7-cb9c-4172-9037-f0bca8bd48a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5494.632" y="4083.8352"/> </glyph> </glyph> <glyph class="macromolecule" id="s2918_sa1304"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUS1 checkpoint homolog (S. pombe) HUGO:HUS1, HGNC:5309, ENTREZ:3364, UNIPROT:O60921 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:9524127, PMID:17493829 References_end</body> </html> </notes> <label text="HUS1"/> <bbox w="80.0" h="40.0" x="5421.734" y="4155.955"/> </glyph> <glyph class="macromolecule" id="s2915_sa1305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="5417.734" y="4113.955"/> <glyph class="state variable" id="_565d04e4-5645-4d5b-b32f-ae8a265f0482"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5452.734" y="4108.955"/> </glyph> </glyph> <glyph class="macromolecule" id="s2917_sa1306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD1 homolog (S. pombe) HUGO:RAD1, HGNC:9806, ENTREZ:5810, UNIPROT:O60671 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="RAD1"/> <bbox w="80.0" h="40.0" x="5415.734" y="4069.955"/> </glyph> <glyph class="macromolecule" id="s2914_sa1307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication factor C (activator 1) 1, 145kDa HUGO:RFC1, HGNC:9969, ENTREZ:5981, UNIPROT:P35251 replication factor C (activator 1) 2, 40kDa HUGO:RFC2, HGNC:9970, ENTREZ:5982, UNIPROT:P35250 replication factor C (activator 1) 3, 38kDa HUGO:RFC3, HGNC:9971, ENTREZ:5983, UNIPROT:P40938 replication factor C (activator 1) 4, 37kDa HUGO:RFC4, HGNC:9972, ENTREZ:5984, UNIPROT:P35249 replication factor C (activator 1) 5, 36.5kDa HUGO:RFC5, HGNC:9973, ENTREZ:5985, UNIPROT:P40937 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="RFC*"/> <bbox w="80.0" h="40.0" x="5502.464" y="4111.8584"/> </glyph> </glyph> <glyph class="complex" id="s3015_csa264" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HUS1:RAD1:RAD9*:TDG Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: 9-1-1 complex activates TDG glycosylase and activates BER PMID:17855402 References_end</body> </html> </notes> <label text="HUS1/RAD1/RAD9*/TDG"/> <bbox w="178.0" h="114.0" x="3078.4722" y="6895.3564"/> <glyph class="macromolecule" id="s3017_sa1387"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thymine-DNA glycosylase HUGO:TDG, HGNC:11700, ENTREZ:6996, UNIPROT:Q13569 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="TDG"/> <bbox w="80.0" h="40.0" x="3089.5273" y="6904.6113"/> <glyph class="state variable" id="_e605fbc8-4539-4f27-b42a-7a32e8e92587"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3084.5273" y="6911.327"/> </glyph> </glyph> <glyph class="macromolecule" id="s3016_sa1388"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUS1 checkpoint homolog (S. pombe) HUGO:HUS1, HGNC:5309, ENTREZ:3364, UNIPROT:O60921 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:9524127, PMID:17493829 References_end</body> </html> </notes> <label text="HUS1"/> <bbox w="80.0" h="40.0" x="3089.2346" y="6948.238"/> </glyph> <glyph class="macromolecule" id="s3018_sa1389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD1 homolog (S. pombe) HUGO:RAD1, HGNC:9806, ENTREZ:5810, UNIPROT:O60671 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660 References_end</body> </html> </notes> <label text="RAD1"/> <bbox w="80.0" h="40.0" x="3171.2346" y="6905.238"/> </glyph> <glyph class="macromolecule" id="s3019_sa1390"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD9 homolog A (S. pombe) HUGO:RAD9A, HGNC:9827, ENTREZ:5883, UNIPROT:Q99638 RAD9 homolog B (S. pombe) HUGO:RAD9B, HGNC:21700, ENTREZ:144715, UNIPROT:Q6WBX8 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:8943031, PMID:17493829 References_end</body> </html> </notes> <label text="RAD9*"/> <bbox w="80.0" h="40.0" x="3169.8394" y="6947.5757"/> <glyph class="state variable" id="_69723cae-18f5-4ef6-937b-18862a9a56c4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3202.3394" y="6942.5757"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s4_csa39" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ku70*:Ku80* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: The complex presents in double amount to cover both ends of broken DNA double helix Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*/Ku80*"/> <bbox w="105.0" h="103.0" x="5628.472" y="6608.3564"/> <glyph class="macromolecule" id="s822_sa555"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <bbox w="80.0" h="40.0" x="5642.691" y="6653.3223"/> <glyph class="state variable" id="_e7ab5b4b-fbd9-46a1-a775-0a56d17900d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5661.1226" y="6648.3223"/> </glyph> </glyph> <glyph class="macromolecule" id="s823_sa556"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="5640.691" y="6612.8154"/> </glyph> </glyph> <glyph class="complex" id="s2392_csa215" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ku70*:Ku80*:Securin* Identifiers_end Maps_Modules_begin: MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17962814 References_end</body> </html> </notes> <label text="Ku70*/Ku80*/Securin*"/> <bbox w="117.0" h="155.0" x="5618.472" y="6726.3564"/> <glyph class="macromolecule" id="s2390_sa1038"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <bbox w="80.0" h="40.0" x="5641.691" y="6820.3223"/> <glyph class="state variable" id="_f8981b9d-1272-4687-b080-f80952586da7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5660.1226" y="6815.3223"/> </glyph> </glyph> <glyph class="macromolecule" id="s2391_sa1039"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <bbox w="80.0" h="40.0" x="5638.691" y="6776.8154"/> </glyph> <glyph class="macromolecule" id="s2388_sa1040"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pituitary tumor-transforming 1, Securin HUGO:PTTG1, HGNC:9690, ENTREZ:9232, UNIPROT:O95997 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:SPINDLE_CHECKPOINT MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17962814, PMID:11238996, PMID:20691907 References_end</body> </html> </notes> <label text="Securin*"/> <bbox w="80.0" h="40.0" x="5635.859" y="6732.488"/> <glyph class="state variable" id="_ffbed7b5-0dfe-413e-b164-ac629779bd0e"> <state value="" variable="S165"/> <bbox w="30.0" h="10.0" x="5632.3506" y="6727.488"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2561_csa1" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LIG3:PARP1:XRCC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="LIG3/PARP*/XRCC1"/> <bbox w="112.0" h="167.0" x="2044.4722" y="7886.3564"/> <glyph class="macromolecule" id="s1804_sa364"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ligase III DNA, ATP-dependent HUGO:LIG3, HGNC:6600, ENTREZ:3980, UNIPROT:P49916 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: For BER: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 For NER: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 Activation of WRN in cancers PMID:18524993 References_end</body> </html> </notes> <label text="LIG3"/> <bbox w="80.0" h="40.0" x="2056.9722" y="7947.8564"/> </glyph> <glyph class="macromolecule" id="s732_sa365"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="2058.017" y="7992.3022"/> <glyph class="state variable" id="_60a17ff4-64eb-4bad-92bb-20fd798bab18"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2107.0857" y="7987.3022"/> </glyph> </glyph> <glyph class="macromolecule" id="s3443_sa1632"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Identifiers_end Maps_Modules_begin: Maps_Modules_end References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="79.0" h="40.0" x="2061.372" y="7897.1562"/> <glyph class="state variable" id="_6143dd14-d0cd-46ff-927c-64020be84b20"> <state value="?" variable="PolyADPribose"/> <bbox w="79.0" h="10.0" x="2057.0413" y="7892.1562"/> </glyph> <glyph class="state variable" id="_10dbc064-e0f0-4e48-b325-94791cbdeb35"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2132.872" y="7912.1562"/> </glyph> <glyph class="state variable" id="_6a11a5f3-cbcf-4f8c-b285-2c1e09ca541e"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="2050.0645" y="7932.1562"/> </glyph> <glyph class="state variable" id="_aae4439a-0693-41a6-a57b-936c47471776"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="2041.3721" y="7916.3857"/> </glyph> <glyph class="state variable" id="_b301b348-e2e0-4781-8c65-2d673a4f7d95"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="2041.3721" y="7926.0874"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s993_csa49" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LIG3:WRN Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ Maps_Modules_end References_begin: Activation of WRN and Lig3 in cancers PMID:18524993 http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 References_end</body> </html> </notes> <label text="LIG3/WRN"/> <bbox w="100.0" h="120.0" x="6495.472" y="7717.3564"/> <glyph class="macromolecule" id="s995_sa588"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ligase III DNA, ATP-dependent HUGO:LIG3, HGNC:6600, ENTREZ:3980, UNIPROT:P49916 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: For BER: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 For NER: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 Activation of WRN in cancers PMID:18524993 References_end</body> </html> </notes> <label text="LIG3"/> <bbox w="80.0" h="40.0" x="6507.472" y="7730.3564"/> </glyph> <glyph class="macromolecule" id="s994_sa589"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="6509.472" y="7776.3564"/> <glyph class="state variable" id="_c6e3f3d3-c999-4940-8881-f105861c3e1c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6543.2197" y="7771.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3040_csa265" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LIG3:XRCC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER Maps_Modules_end</body> </html> </notes> <label text="LIG3/XRCC1"/> <bbox w="100.0" h="120.0" x="980.47217" y="7830.3564"/> <glyph class="macromolecule" id="s3042_sa1399"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ligase III DNA, ATP-dependent HUGO:LIG3, HGNC:6600, ENTREZ:3980, UNIPROT:P49916 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: For BER: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 For NER: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 Activation of WRN in cancers PMID:18524993 References_end</body> </html> </notes> <label text="LIG3"/> <bbox w="80.0" h="40.0" x="991.7436" y="7838.4194"/> </glyph> <glyph class="macromolecule" id="s3041_sa1400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="994.7436" y="7881.4194"/> <glyph class="state variable" id="_3bcd32c8-f0b6-4430-a93c-f6abda5649ac"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1043.8121" y="7876.4194"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3188_csa267" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LIG4:PNK*:XRCC4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:15385968 PMID:12032095 References_end</body> </html> </notes> <label text="LIG4/PNK*/XRCC4"/> <bbox w="107.0" h="158.0" x="5650.472" y="7010.3564"/> <glyph class="macromolecule" id="s3186_sa1467"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Polynucleotide kinase 3'-phosphatase HUGO:PNKP, HGNC:9154, ENTREZ:11284, UNIPROT:Q96T60 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ MODULE:BER Maps_Modules_end References_begin: PMID:20691907 For C_NHEJ PMID:17638872, PMID:15385968, PMID:12032095 For BER PMID:11163244, PMID:19546231 References_end</body> </html> </notes> <label text="PNK*"/> <bbox w="80.0" h="40.0" x="5661.472" y="7019.3564"/> </glyph> <glyph class="macromolecule" id="s3189_sa1470"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 4 HUGO:XRCC4, HGNC:12831, ENTREZ:7518, UNIPROT:Q13426 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="XRCC4"/> <bbox w="74.0" h="34.0" x="5664.1646" y="7061.433"/> </glyph> <glyph class="macromolecule" id="s3190_sa1471"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ligase IV, DNA, ATP-dependent HUGO:LIG4, HGNC:6601, ENTREZ:3981, UNIPROT:P49917 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:12471202, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="LIG4"/> <bbox w="80.0" h="40.0" x="5665.241" y="7100.433"/> </glyph> </glyph> <glyph class="complex" id="s3228_csa32" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LIG4:XLF*:XRCC4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end</body> </html> </notes> <label text="LIG4/XLF*/XRCC4"/> <bbox w="106.0" h="135.0" x="5898.472" y="7708.3564"/> <glyph class="macromolecule" id="s1806_sa517"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ligase IV, DNA, ATP-dependent HUGO:LIG4, HGNC:6601, ENTREZ:3981, UNIPROT:P49917 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:12471202, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="LIG4"/> <bbox w="80.0" h="40.0" x="5910.972" y="7749.3564"/> </glyph> <glyph class="macromolecule" id="s921_sa518"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XLF nonhomologous end-joining factor 1 HUGO:C_NHEJ1, HGNC:25737, ENTREZ:79840, UNIPROT:Q9H9Q4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:16439205 References_end</body> </html> </notes> <label text="XLF*"/> <bbox w="80.0" h="40.0" x="5911.972" y="7783.3564"/> </glyph> <glyph class="macromolecule multimer" id="s1807_sa519"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 4 HUGO:XRCC4, HGNC:12831, ENTREZ:7518, UNIPROT:Q13426 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869 References_end</body> </html> </notes> <label text="XRCC4"/> <bbox w="80.0" h="40.0" x="5907.972" y="7709.3564"/> <glyph class="unit of information" id="_c0ad148c-1177-4d26-b20b-70d11de30176"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5937.972" y="7704.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2495_csa220" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAX:MYC Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:15814658, PMID:12584560 References_end</body> </html> </notes> <label text="MAX/MYC"/> <bbox w="100.0" h="120.0" x="4559.472" y="2149.3562"/> <glyph class="macromolecule" id="s2497_sa1117"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MYC associated factor X HUGO:MAX, HGNC:6913, ENTREZ:4149, UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:2006410, PMID:15121849, PMID:8425218, PMID:16908182 References_end</body> </html> </notes> <label text="MAX"/> <bbox w="80.0" h="40.0" x="4568.589" y="2200.664"/> </glyph> <glyph class="macromolecule" id="s3397_sa1598"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC, HGNC:7553, ENTREZ:4609, UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4572.472" y="2158.8562"/> <glyph class="state variable" id="_397e32e0-1b30-4ee5-af3b-65ffc98c5c3d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4567.472" y="2173.8562"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s771_csa27" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MBD4:MLH1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:MMR Maps_Modules_end References_begin: BER and MMR interaction and G2/M arrest in response to o6-meG formation 14614141 References_end</body> </html> </notes> <label text="MBD4/MLH1"/> <bbox w="100.0" h="120.0" x="3156.4722" y="6597.3564"/> <glyph class="macromolecule" id="s770_sa492"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="3166.3596" y="6649.8228"/> </glyph> <glyph class="macromolecule" id="s772_sa493"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: methyl-CpG binding domain protein 4 HUGO:MBD4, HGNC:6919, ENTREZ:8930, UNIPROT:O95243 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:MMR Maps_Modules_end References_begin: PMID:10545939, PMID:12417741, PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="MBD4"/> <bbox w="80.0" h="40.0" x="3167.3596" y="6606.8228"/> </glyph> </glyph> <glyph class="complex" id="s2213_csa198" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="MCM2/MCM3/MCM4/MCM5/MCM6/MCM7"/> <bbox w="182.0" h="156.0" x="5393.472" y="784.35626"/> <glyph class="macromolecule" id="s2219_sa870"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 2 HUGO:MCM2, HGNC:6944, ENTREZ:4171, UNIPROT:P49736 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM2"/> <bbox w="80.0" h="40.0" x="5399.0938" y="791.4843"/> </glyph> <glyph class="macromolecule" id="s2214_sa871"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 3 HUGO:MCM3, HGNC:6945, ENTREZ:4172, UNIPROT:P25205 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM3"/> <bbox w="80.0" h="40.0" x="5398.0938" y="834.4843"/> </glyph> <glyph class="macromolecule" id="s2215_sa872"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 4 HUGO:MCM4, HGNC:6947, ENTREZ:4173, UNIPROT:P33991 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM4"/> <bbox w="80.0" h="40.0" x="5398.0938" y="877.4843"/> </glyph> <glyph class="macromolecule" id="s2216_sa873"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 7 HUGO:MCM7, HGNC:6950, ENTREZ:4176, UNIPROT:P33993 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM7"/> <bbox w="80.0" h="40.0" x="5481.0938" y="876.4843"/> </glyph> <glyph class="macromolecule" id="s2217_sa874"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 6 HUGO:MCM6, HGNC:6949, ENTREZ:4175, UNIPROT:Q14566 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM6"/> <bbox w="80.0" h="40.0" x="5483.0938" y="834.4843"/> </glyph> <glyph class="macromolecule" id="s2218_sa875"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 5 HUGO:MCM5, HGNC:6948, ENTREZ:4174, UNIPROT:P33992 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="MCM5"/> <bbox w="80.0" h="40.0" x="5480.0938" y="790.4843"/> </glyph> </glyph> <glyph class="complex" id="s3249_csa268" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MCM8*:MCM9* Identifiers_end</body> </html> </notes> <label text="MCM8*/MCM9*"/> <bbox w="100.0" h="120.0" x="7387.472" y="7545.3564"/> <glyph class="macromolecule" id="s3247_sa1536"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 8 HUGO:C20orf154, HGNC:16147, ENTREZ:84515, UNIPROT:Q9UJA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair PMID:22771115 References_end</body> </html> </notes> <label text="MCM9*"/> <bbox w="80.0" h="40.0" x="7399.472" y="7601.3564"/> </glyph> <glyph class="macromolecule" id="s3248_sa1537"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: minichromosome maintenance complex component 9 HUGO:C6orf61, HGNC:21484, ENTREZ:254394, UNIPROT:Q9NXL9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair PMID:22771115 References_end</body> </html> </notes> <label text="MCM8*"/> <bbox w="80.0" h="40.0" x="7395.472" y="7552.3564"/> </glyph> </glyph> <glyph class="complex" id="s1504_csa36" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MDC1:RNF8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:C_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:18006705 RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR PMID:18001825 Complex RNF8:MDC1 ubiquitinates Ku80 and causes it's dissociation from DNA and degradation.This bring to shift from C_NHEJ to HR PMID:18001825, PMID:18678709 References_end</body> </html> </notes> <label text="MDC1/RNF8"/> <bbox w="100.0" h="120.0" x="7098.472" y="6116.3564"/> <glyph class="macromolecule" id="s1505_sa535"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring finger protein 8 HUGO:RNF8, HGNC:10071, ENTREZ:9025, UNIPROT:O76064 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:18006705, PMID:19772495 References_end</body> </html> </notes> <label text="RNF8"/> <bbox w="80.0" h="40.0" x="7109.0557" y="6175.4395"/> </glyph> <glyph class="macromolecule" id="s3218_sa536"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mediator of DNA-damage checkpoint 1 HUGO:MDC1, HGNC:21163, ENTREZ:9656, UNIPROT:Q2TAZ4 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:C_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786 For S-phase checkpoint PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890 References_end</body> </html> </notes> <label text="MDC1"/> <bbox w="80.0" h="40.0" x="7108.0557" y="6127.4395"/> <glyph class="state variable" id="_e5316885-2b0e-4412-afe3-db66fcb98084"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7100.5557" y="6142.4077"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s551_csa16" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLH1:MLH3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MLH1/MLH3"/> <bbox w="114.0" h="118.0" x="4342.472" y="6826.3564"/> <glyph class="macromolecule" id="s552_sa464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="4360.972" y="6834.3564"/> </glyph> <glyph class="macromolecule" id="s553_sa465"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 3 (E. coli) HUGO:MLH3, HGNC:7128, ENTREZ:27030, UNIPROT:Q9UHC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH3"/> <bbox w="80.0" h="40.0" x="4359.472" y="6876.3564"/> </glyph> </glyph> <glyph class="complex" id="s548_csa17" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLH1:PMS1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MLH1/PMS1"/> <bbox w="114.0" h="117.0" x="4340.472" y="6957.3564"/> <glyph class="macromolecule" id="s549_sa466"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="4356.972" y="6967.3564"/> </glyph> <glyph class="macromolecule" id="s550_sa467"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PMS1 postmeiotic segregation increased 1 (S. cerevisiae) HUGO:PMS1, HGNC:9121, ENTREZ:5378, UNIPROT:P54277 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="PMS1"/> <bbox w="80.0" h="40.0" x="4355.472" y="7010.3564"/> </glyph> </glyph> <glyph class="complex" id="s545_csa19" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLH1:PMS2 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="MLH1/PMS2"/> <bbox w="113.0" h="117.0" x="3922.4722" y="6738.3564"/> <glyph class="macromolecule" id="s546_sa470"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) HUGO:MLH1, HGNC:7127, ENTREZ:4292, UNIPROT:P40692 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MLH1"/> <bbox w="80.0" h="40.0" x="3941.4722" y="6752.3564"/> </glyph> <glyph class="macromolecule" id="s547_sa471"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PMS1 postmeiotic segregation increased 2 (S. cerevisiae) HUGO:PMS2, HGNC:9122, ENTREZ:5395, UNIPROT:P54278 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="PMS2"/> <bbox w="80.0" h="40.0" x="3944.4722" y="6790.3564"/> </glyph> </glyph> <glyph class="complex" id="s1260_csa76" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RAD5*:UBC12*:UBE2N Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19851286 References_end</body> </html> </notes> <label text="MMS2*/RAD5/UBC13*"/> <bbox w="109.0" h="157.0" x="10067.473" y="6814.3564"/> <glyph class="macromolecule" id="s1275_sa685"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) HUGO:UBE2N, HGNC:12492, ENTREZ:7334, UNIPROT:P61088 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="UBE2N"/> <bbox w="80.0" h="40.0" x="10076.611" y="6866.3945"/> </glyph> <glyph class="macromolecule" id="s1273_sa686"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2 variant 2 HUGO:UBE2V2, HGNC:12495, ENTREZ:7336, UNIPROT:Q15819 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:20675655, PMID:16518696, PMID:18525240, PMID:18157158, PMID:19258535, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="UBC12*"/> <bbox w="80.0" h="40.0" x="10077.611" y="6821.3945"/> </glyph> <glyph class="macromolecule" id="s1262_sa687"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SNF2 histone linker PHD RING helicase, Rad5 HUGO:SHPRH, HGNC:19336, ENTREZ:257218, UNIPROT:Q8NBR7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:10880451, PMID:16224103, PMID:19851286, PMID:18647995 References_end</body> </html> </notes> <label text="RAD5*"/> <bbox w="80.0" h="40.0" x="10077.611" y="6907.3945"/> </glyph> </glyph> <glyph class="complex" id="s1362_csa47" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MRE11*:NBS1*:RAD50 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 Double strand breaks sensor. MRN complex association is a first event after the DNA damage PMID:16531125, PMID:17303408, PMID:16163361 For S-phase checkpoint PMID:19793801, PMID:11850621 References_end</body> </html> </notes> <label text="MRE11*/NBS*/RAD50"/> <bbox w="95.0" h="146.0" x="7342.472" y="5514.3564"/> <glyph class="macromolecule" id="s1520_sa583"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO:MRE11A, HGNC:7230, ENTREZ:4361, UNIPROT:P49959 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) HUGO:RE11B, HGNC:7231, ENTREZ:4362 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="MRE11*"/> <bbox w="80.0" h="40.0" x="7349.222" y="5520.8564"/> </glyph> <glyph class="macromolecule" id="s1364_sa584"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD50 homolog (S. cerevisiae) HUGO:RAD50, HGNC:9816, ENTREZ:10111, UNIPROT:Q92878 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="RAD50"/> <bbox w="80.0" h="40.0" x="7349.222" y="5560.8564"/> </glyph> <glyph class="macromolecule" id="s3216_sa585"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nibrin HUGO:NBN, HGNC:7652, ENTREZ:4683, UNIPROT:O60934 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:HR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763 For S-phase checkpoint PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="NBS1*"/> <bbox w="80.0" h="40.0" x="7348.722" y="5601.4487"/> <glyph class="state variable" id="_eadee101-d6f4-49cb-8f18-4d57ccf4ac65"> <state value="P" variable="S343"/> <bbox w="35.0" h="10.0" x="7331.222" y="5624.633"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s542_csa18" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MSH2:MSH3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="MSH2/MSH3"/> <bbox w="110.0" h="113.0" x="4341.472" y="6707.3564"/> <glyph class="macromolecule" id="s622_sa468"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 3 (E. coli) HUGO:MSH3, HGNC:7326, ENTREZ:4437, UNIPROT:P20585 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:SSA Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH3"/> <bbox w="80.0" h="40.0" x="4357.472" y="6762.3564"/> </glyph> <glyph class="macromolecule" id="s623_sa469"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="4357.972" y="6720.3564"/> <glyph class="state variable" id="_1d9f0792-8912-457b-9e0f-f59a08e3a12b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4352.972" y="6735.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1611_csa98" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MSH2:MSH3:SLX4* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2/MSH3/SLX4*"/> <bbox w="122.0" h="166.0" x="4837.472" y="7112.3564"/> <glyph class="macromolecule" id="s1612_sa738"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BTB (POZ) domain containing 12 Structure-specific endonuclease subunit SLX4 HUGO:BTBD12, HGNC:23845, ENTREZ:84464, UNIPROT:Q8IY92 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236, PMID:22101340 References_end</body> </html> </notes> <label text="SLX4*"/> <bbox w="80.0" h="40.0" x="4861.472" y="7213.3564"/> </glyph> <glyph class="macromolecule" id="s2787_sa739"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 3 (E. coli) HUGO:MSH3, HGNC:7326, ENTREZ:4437, UNIPROT:P20585 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:SSA Maps_Modules_end References_begin: PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH3"/> <bbox w="80.0" h="40.0" x="4862.472" y="7166.8564"/> </glyph> <glyph class="macromolecule" id="s2788_sa740"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="4859.972" y="7121.8564"/> <glyph class="state variable" id="_32ce32b8-9c60-4fe6-be40-54d6b4cadd98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4854.972" y="7136.8564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s539_csa20" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MSH2:MSH6 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="MSH2/MSH6"/> <bbox w="109.0" h="113.0" x="3930.4722" y="6618.3564"/> <glyph class="macromolecule" id="s636_sa472"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="3946.3357" y="6629.8125"/> <glyph class="state variable" id="_3d435cc5-3baa-455b-8f2d-d202d5ae2328"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3938.8357" y="6644.8125"/> </glyph> </glyph> <glyph class="macromolecule" id="s637_sa473"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 6 (E. coli) HUGO:MSH6, HGNC:7329, ENTREZ:2956, UNIPROT:P52701 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MSH6"/> <bbox w="80.0" h="40.0" x="3947.3357" y="6671.8125"/> <glyph class="state variable" id="_2e37f0ad-f544-49f7-a39d-11b3c53bec1f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3939.8357" y="6686.8125"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s760_csa5" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MSH2:MSH6:MUTH* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768 References_end</body> </html> </notes> <label text="MSH2/MSH6/MUTH*"/> <bbox w="169.0" h="112.0" x="1988.4722" y="6890.3564"/> <glyph class="macromolecule" id="s761_sa67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="1994.4375" y="6940.004"/> <glyph class="state variable" id="_5441aecb-a7a8-43dc-bda6-c24360242dc5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1989.4375" y="6955.004"/> </glyph> </glyph> <glyph class="macromolecule" id="s3400_sa389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutY homolog (E. coli) HUGO:MUTYH, HGNC:7527, ENTREZ:4595, UNIPROT:Q9UIF7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:23507534 References_end</body> </html> </notes> <label text="MUTH*"/> <bbox w="80.0" h="40.0" x="2066.2766" y="6926.0195"/> </glyph> <glyph class="macromolecule" id="s762_sa391"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 6 (E. coli) HUGO:MSH6, HGNC:7329, ENTREZ:2956, UNIPROT:P52701 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MSH6"/> <bbox w="80.0" h="40.0" x="1994.2765" y="6896.609"/> <glyph class="state variable" id="_43143fe7-061b-4474-86c9-ef9a477c949c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1989.2765" y="6911.609"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s755_csa24" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MSH2:MSH6:OGG1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768 References_end</body> </html> </notes> <label text="MSH2/MSH6/OGG1"/> <bbox w="174.0" h="119.0" x="1974.4722" y="6764.3564"/> <glyph class="macromolecule" id="s756_sa483"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 8-oxoguanine DNA glycosylase HUGO:OGG1, HGNC:8125, ENTREZ:4968, UNIPROT:Q9Y6C4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:11307145, PMID:11948476, PMID:15703371, PMID:19847258, PMID:16697054 References_end</body> </html> </notes> <label text="OGG1"/> <bbox w="80.0" h="40.0" x="1990.2765" y="6775.0195"/> </glyph> <glyph class="macromolecule" id="s757_sa484"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) HUGO:MSH2, HGNC:7325, ENTREZ:4436, UNIPROT:P43246 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER MODULE:SSA Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:19847258, PMID:18406444, PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="MSH2"/> <bbox w="80.0" h="40.0" x="1989.2765" y="6817.0195"/> <glyph class="state variable" id="_9448bf99-b431-4b01-b411-41f8376ac115"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1984.2765" y="6832.0195"/> </glyph> </glyph> <glyph class="macromolecule" id="s758_sa485"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mutS homolog 6 (E. coli) HUGO:MSH6, HGNC:7329, ENTREZ:2956, UNIPROT:P52701 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:18157157, PMID:16612326, PMID:15703371, PMID:19847258, PMID:16697054, PMID:16612326, PMID:18406444 References_end</body> </html> </notes> <label text="MSH6"/> <bbox w="80.0" h="40.0" x="2065.2766" y="6805.0195"/> <glyph class="state variable" id="_7b32cda1-824b-478f-b362-e0ce5e91480e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2060.2766" y="6820.0195"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2499_csa222" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIZ1*:MYC:PKMYT1 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: Repression of p15INK4b expression by Myc through association with Miz-1: 9308237, 11283613 Repression of pINK expression by BMI1: 17936558 References_end</body> </html> </notes> <label text="MYC/MIZ1*"/> <bbox w="100.0" h="145.0" x="4576.472" y="2298.3562"/> <glyph class="macromolecule" id="s2253_sa908"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, membrane associated tyrosine/threonine 1 HUGO:PKMYT1, HGNC:29650, ENTREZ:9088, UNIPROT:Q99640 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:10504341, PMID:10373560, PMID:12738781 References_end</body> </html> </notes> <label text="PKMYT1"/> <bbox w="80.0" h="40.0" x="4589.972" y="2303.8562"/> <glyph class="state variable" id="_14f90538-b7c9-4def-8044-2476b2b3cba3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4582.472" y="2318.8562"/> </glyph> </glyph> <glyph class="macromolecule" id="s2500_sa1118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC, HGNC:7553, ENTREZ:4609, UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4590.589" y="2395.164"/> <glyph class="state variable" id="_23b636ec-f87a-471b-aea1-f5a723dedb61"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4585.589" y="2410.164"/> </glyph> </glyph> <glyph class="macromolecule" id="s2501_sa1122"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: zinc finger and BTB domain containing 17, MIZ1 HUGO:ZBTB17, HGNC:12936, ENTREZ:7709, UNIPROT:Q13105 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:9312026, PMID:15095404, PMID:19901969, PMID:19815509 References_end</body> </html> </notes> <label text="MIZ1*"/> <bbox w="80.0" h="40.0" x="4588.4434" y="2345.891"/> </glyph> </glyph> <glyph class="complex" id="s2507_csa223" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MYC:p107* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="MYC/p107*"/> <bbox w="100.0" h="120.0" x="4610.472" y="667.35626"/> <glyph class="macromolecule" id="s2509_sa1129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma-like 1 (p107) HUGO:RBL1, HGNC:9893, ENTREZ:5933, UNIPROT:P28749 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G1_CC_PHASE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="p107*"/> <bbox w="80.0" h="40.0" x="4617.7837" y="729.1993"/> <glyph class="state variable" id="_fbf9401c-1675-4786-b783-c6e6f78a85be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4692.7837" y="740.6129"/> </glyph> </glyph> <glyph class="macromolecule" id="s2508_sa1130"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) HUGO:MYC, HGNC:7553, ENTREZ:4609, UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end References_begin: PMID:20551172, PMID:21406394, PMID:17873522, PMID:17558397 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="4619.7837" y="684.1993"/> <glyph class="state variable" id="_70acd4da-7bb9-4936-a84f-3f1a16bb9e10"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4614.7837" y="699.1993"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s774_csa28" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NTH1*:XPG* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="NTH1*/XPG*"/> <bbox w="166.0" h="79.0" x="1983.4722" y="6566.3564"/> <glyph class="macromolecule" id="s896_sa494"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nth endonuclease III-like 1 (E. coli) HUGO:NTHL1, HGNC:8028, ENTREZ:4913, UNIPROT:P78549 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="NTH1*"/> <bbox w="80.0" h="40.0" x="2064.4722" y="6582.3564"/> </glyph> <glyph class="macromolecule" id="s895_sa495"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: excision repair cross-complementing rodent repair deficiency, complementation group 5 HUGO:ERCC5, HGNC:3437, ENTREZ:2073, UNIPROT:P28715 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPG*"/> <bbox w="80.0" h="40.0" x="1989.0154" y="6582.395"/> </glyph> </glyph> <glyph class="complex" id="s2198_csa197" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="ORC1*/ORC2*/ORC3*/ORC4*/ORC5*/ORC6*"/> <bbox w="183.0" h="153.0" x="5393.472" y="487.35626"/> <glyph class="macromolecule" id="s2201_sa856"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 6-like (yeast) HUGO:ORC6L, HGNC:17151, ENTREZ:23594, UNIPROT:Q9Y5N6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC6*"/> <bbox w="80.0" h="40.0" x="5488.4424" y="575.0338"/> </glyph> <glyph class="macromolecule" id="s2199_sa857"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 5-like (yeast) HUGO:ORC5L, HGNC:8491, ENTREZ:5001, UNIPROT:O43913 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC5*"/> <bbox w="80.0" h="40.0" x="5489.4424" y="535.0338"/> </glyph> <glyph class="macromolecule" id="s2200_sa858"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 4-like (yeast) HUGO:ORC4L, HGNC:8490, ENTREZ:5000, UNIPROT:O43929 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC4*"/> <bbox w="80.0" h="40.0" x="5488.4424" y="493.0338"/> </glyph> <glyph class="macromolecule" id="s2204_sa859"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 3-like (yeast) HUGO:ORC3L, HGNC:8489, ENTREZ:23595, UNIPROT:Q9UNT6 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC3*"/> <bbox w="80.0" h="40.0" x="5405.4424" y="574.0338"/> </glyph> <glyph class="macromolecule" id="s2202_sa860"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 2-like (yeast) HUGO:ORC2L, HGNC:8488, ENTREZ:4999, UNIPROT:Q13416 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC2*"/> <bbox w="80.0" h="40.0" x="5405.4424" y="533.0338"/> </glyph> <glyph class="macromolecule" id="s2203_sa861"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: origin recognition complex, subunit 1-like (yeast) HUGO:ORC1L, HGNC:8487, ENTREZ:4998, UNIPROT:Q13415 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:12909626 References_end</body> </html> </notes> <label text="ORC1*"/> <bbox w="80.0" h="40.0" x="5405.4424" y="492.0338"/> </glyph> </glyph> <glyph class="complex" id="s2563_csa40" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LIG1:PARP1:PCNA Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333 References_end</body> </html> </notes> <label text="PARP*/LIG3/PCNA"/> <bbox w="106.0" h="149.0" x="3127.4722" y="7760.3564"/> <glyph class="macromolecule" id="s100_sa557"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ligase I, DNA, ATP-dependent HUGO:LIG1, HGNC:6598, ENTREZ:3978, UNIPROT:P18858 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:NER MODULE:MMR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 ,PMID:24050180 References_end</body> </html> </notes> <label text="LIG1"/> <bbox w="80.0" h="40.0" x="3143.9722" y="7808.8564"/> </glyph> <glyph class="macromolecule" id="s198_sa558"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="3143.9722" y="7848.8564"/> <glyph class="state variable" id="_afdde622-0ae8-42d5-89ee-14f9ac19fb74"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="3132.956" y="7843.8564"/> </glyph> <glyph class="state variable" id="_f1072481-5140-422b-b7ec-35429e8b4d1f"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="3128.9722" y="7863.8564"/> </glyph> <glyph class="state variable" 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MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="80.0" h="40.0" x="3141.1086" y="7764.238"/> <glyph class="state variable" id="_a4dd3279-d415-4643-97f2-0009bd97de0e"> <state value="?" variable="PolyADPribose"/> <bbox w="80.0" h="10.0" x="3136.7231" y="7759.238"/> </glyph> <glyph class="state variable" id="_7642154f-431c-4abb-80ec-2dd7036007cb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3213.6086" y="7779.238"/> </glyph> <glyph class="state variable" id="_57a724b3-cc87-4deb-9b5b-3e30fbd3e229"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="3129.9111" y="7799.238"/> </glyph> <glyph class="state variable" id="_ed4dd53b-ea0e-4033-97e5-4813c5324b7b"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="3121.1086" y="7783.4673"/> </glyph> <glyph class="state variable" id="_190ca5f9-7be8-4a73-adad-056ad220c40c"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="3121.1086" y="7793.169"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2557_csa4" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARP1:PCNA:POLB:POLD*:POLE*:RFC* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:19748837, PMID:12637553, PMID:10858306, PMID:11948190, PMID:16442856 References_end</body> </html> </notes> <label text="PARP*/PCNA/POLB/POLD*/POLE*/RFC*"/> <bbox w="254.0" h="115.0" x="3002.4722" y="7214.3564"/> <glyph class="macromolecule" id="s112_sa384"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication factor C (activator 1) 1, 145kDa HUGO:RFC1, HGNC:9969, ENTREZ:5981, UNIPROT:P35251 replication factor C (activator 1) 2, 40kDa HUGO:RFC2, HGNC:9970, ENTREZ:5982, UNIPROT:P35250 replication factor C (activator 1) 3, 38kDa HUGO:RFC3, HGNC:9971, ENTREZ:5983, UNIPROT:P40938 replication factor C (activator 1) 4, 37kDa HUGO:RFC4, HGNC:9972, ENTREZ:5984, UNIPROT:P35249 replication factor C (activator 1) 5, 36.5kDa HUGO:RFC5, HGNC:9973, ENTREZ:5985, UNIPROT:P40937 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20478261, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="RFC*"/> <bbox w="80.0" h="40.0" x="3162.4722" y="7224.3564"/> </glyph> <glyph class="macromolecule" id="s190_sa385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PolB, polymerase (DNA directed), beta HUGO:POLB, HGNC:9174, ENTREZ:5423, UNIPROT:P06746 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs PMID:20510258, PMID:21251944 References_end</body> </html> </notes> <label text="POLB"/> <bbox w="80.0" h="40.0" x="3077.9722" y="7222.8564"/> </glyph> <glyph class="macromolecule" id="s194_sa386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), delta 1, catalytic subunit 125kDa HUGO:POLD1, HGNC:9175, ENTREZ:5424, UNIPROT:P28340 polymerase (DNA directed), delta 2, regulatory subunit 50kDa HUGO:POLD2, HGNC:9176, ENTREZ:5425, UNIPROT:P49005 polymerase (DNA-directed), delta 3, accessory subunit HUGO:POLD3, HGNC:20932, ENTREZ:10714, UNIPROT:Q15054 polymerase (DNA-directed), delta 4 HUGO:POLD4, HGNC:14106, ENTREZ:57804, UNIPROT:Q9HCU8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20478261 For A_NHEJ PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 References_end</body> </html> </notes> <label text="POLD*"/> <bbox w="80.0" h="40.0" x="3008.9722" y="7262.8564"/> </glyph> <glyph class="macromolecule" id="s195_sa387"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), epsilon HUGO:POLE, HGNC:9177, ENTREZ:5426, UNIPROT:Q07864 polymerase (DNA directed), epsilon 2 (p59 subunit) HUGO:POLE2, HGNC:9178, ENTREZ:5427, UNIPROT:P56282 polymerase (DNA directed), epsilon 3 (p17 subunit) HUGO:POLE3, HGNC:13546, ENTREZ:54107, UNIPROT:Q9NRF9 polymerase (DNA-directed), epsilon 4 (p12 subunit) HUGO:POLE4, HGNC:18755, ENTREZ:56655, UNIPROT:Q9NR33 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="POLE*"/> <bbox w="80.0" h="40.0" x="3010.9722" y="7222.8564"/> </glyph> <glyph class="macromolecule" id="s196_sa388"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="3085.9722" y="7263.8564"/> <glyph class="state variable" id="_5e5f3203-c232-4953-b41f-9322cc710dd6"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="3074.956" y="7258.8564"/> </glyph> <glyph class="state variable" id="_ce2b530d-b3c4-4469-a501-eb4390020884"> <state value="" variable="K164"/> <bbox w="30.0" h="10.0" x="3070.9722" y="7278.8564"/> </glyph> <glyph class="state variable" id="_ee5b1442-0b23-444d-8be2-24ae2d88b653"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3104.4036" y="7298.8564"/> </glyph> <glyph class="state variable" id="_f500a874-b405-47c2-9982-2fc47e7d57e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3080.9722" y="7298.8564"/> </glyph> <glyph class="state variable" id="_3ec9da6c-08c3-4f2e-8072-3854576a66cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3120.9722" y="7298.8564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2566_sa1161"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="80.0" h="40.0" x="3161.1086" y="7262.8325"/> <glyph class="state variable" id="_999449a5-ce6b-482d-a207-edd50da47d02"> <state value="" variable="PolyADPribose"/> <bbox w="75.0" h="10.0" x="3159.2231" y="7257.8325"/> </glyph> <glyph class="state variable" id="_ba01bec2-bcda-44ab-ae29-ea322b8aa359"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3236.1086" y="7277.8325"/> </glyph> <glyph class="state variable" id="_bbadc477-d951-4f1d-a488-6d05966c1da8"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="3149.9111" y="7297.8325"/> </glyph> <glyph class="state variable" id="_9ea2f839-a2c4-4364-a272-20cecab1a1f9"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="3141.1086" y="7282.062"/> </glyph> <glyph class="state variable" id="_8b22356d-b48c-4912-bd02-d2e185287084"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="3141.1086" y="7291.7637"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2572_csa229" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARP1:p53* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="PARP*/p53*"/> <bbox w="100.0" h="120.0" x="4442.472" y="3808.3562"/> <glyph class="macromolecule" id="s2574_sa1170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor protein p53 HUGO:TP53, HGNC:11998, ENTREZ:7157, UNIPROT:Q9NP68 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:6396087, PMID:21340684, PMID:20457558, PMID:20182602, PMID:20066118 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="4452.4526" y="3864.5222"/> <glyph class="state variable" id="_f75b4ea0-5761-4b16-b1ef-deeacedbbe0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4447.4526" y="3879.5222"/> </glyph> <glyph class="state variable" id="_7f98573f-6418-46bf-b786-b551aca75cc6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4490.229" y="3859.5222"/> </glyph> </glyph> <glyph class="macromolecule" id="s2573_sa1172"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="78.0" h="42.0" x="4446.1416" y="3812.3975"/> <glyph class="state variable" id="_1c12fc5f-9cd2-4716-84d0-52f7c6917b70"> <state value="" variable="PolyADPribose"/> <bbox w="75.0" h="10.0" x="4443.3657" y="3807.3975"/> </glyph> <glyph class="state variable" id="_38b7fd94-2cc0-486e-9432-ab3790214e64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4519.1416" y="3828.3975"/> </glyph> <glyph class="state variable" id="_4ca5ff7f-1fb7-4046-8393-24f873e7838f"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="4434.724" y="3849.3975"/> </glyph> <glyph class="state variable" id="_bd97ef21-ddec-4bcf-910e-7fdb9e6e6b3d"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="4426.1416" y="3832.8384"/> </glyph> <glyph class="state variable" id="_f253ff2b-d64c-4b2b-9582-c2993e8d64f3"> <state 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="79.0" h="40.0" x="2654.3054" y="7767.023"/> <glyph class="state variable" id="_d5d8bc3a-649c-4de9-9146-94727df1aa6a"> <state value="?" variable="PolyADPribose"/> <bbox w="79.0" h="10.0" x="2649.9746" y="7762.023"/> </glyph> <glyph class="state variable" id="_76d9dbc3-bb5c-41be-9efd-f94e3e67f1ef"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2725.8054" y="7782.023"/> </glyph> <glyph class="state variable" id="_793628b5-ec60-4bef-98e1-6d913c3bd9a3"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="2642.9978" y="7802.023"/> </glyph> <glyph class="state variable" id="_5d0ed01a-8c27-45e3-85ba-938cb7fcc471"> <state value="" 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PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARPs in cellular functions PMID:22713970 PARP1 and PARP2 in HR and in inhibition of C_NHEJ PMID:22469522, PMID:196269035 PARP2 in chromatin remodeling PMID:22469522, PMID:22713970 References_end</body> </html> </notes> <label text="PARP2"/> <bbox w="80.0" h="40.0" x="2652.9006" y="7809.9277"/> <glyph class="state variable" id="_f52e8be4-b9a8-4e5b-9b1d-0fb53789ffe9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2725.4006" y="7824.2075"/> </glyph> <glyph class="state variable" id="_766d8ece-fdc8-46a3-8b61-439dbb98389b"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="2682.8098" y="7804.9277"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3361_csa271" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARP1:PARP3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 References_end</body> </html> </notes> <label text="PARP1/PARP3"/> <bbox w="100.0" h="120.0" x="2646.4722" y="7896.3564"/> <glyph class="macromolecule" id="s3363_sa1569"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 3 HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 PARP3 in chromatin remodeling PMID:22469522, PMID:22713970 APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ PARP3 in C_NHEJ PMID:22743550 References_end</body> </html> </notes> <label text="PARP3"/> <bbox w="80.0" h="40.0" x="2657.4722" y="7955.023"/> </glyph> <glyph class="macromolecule" id="s3362_sa1576"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="79.0" h="40.0" x="2659.115" y="7908.9277"/> <glyph class="state variable" id="_a8312e74-0bd5-467c-9dc1-dbe3b9f43e37"> <state value="?" variable="PolyADPribose"/> <bbox w="79.0" h="10.0" x="2654.7842" y="7903.9277"/> </glyph> <glyph class="state variable" id="_7eb77a8e-6303-4d54-a87a-27688f7a0201"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2730.615" y="7923.9277"/> </glyph> <glyph class="state variable" id="_2ba24692-ce6f-46b9-a159-4b5e465b5cc9"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="2647.8074" y="7943.9277"/> </glyph> <glyph class="state variable" id="_da718bce-920e-44e2-ad03-640b844e0278"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="2639.115" y="7928.157"/> </glyph> <glyph class="state variable" id="_0d88aa0f-512f-4bbd-94f3-41983e7b0447"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="2639.115" y="7937.859"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3280_csa86" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARP1:PNK*:POLB:WRN:XRCC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:19748837, PMID:12637553, PMID:10858306, PMID:11948190, PMID:16442856, PMID:18398454, PMID:16449207 References_end</body> </html> </notes> <label text="PARP1/POLB/PNK*/XRCC1/WRN"/> <bbox w="203.0" h="184.0" x="2009.4722" y="7691.3564"/> <glyph class="macromolecule" id="s3273_sa707"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PolB, polymerase (DNA directed), beta HUGO:POLB, HGNC:9174, ENTREZ:5423, UNIPROT:P06746 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs PMID:20510258, PMID:21251944 References_end</body> </html> </notes> <label text="POLB"/> <bbox w="80.0" h="40.0" x="2110.9722" y="7752.8564"/> </glyph> <glyph class="macromolecule" id="s3274_sa708"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="2023.0171" y="7803.3022"/> <glyph class="state variable" id="_38d58990-d949-4a49-a849-1aad3e805faa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2072.0857" y="7798.3022"/> </glyph> </glyph> <glyph class="macromolecule" id="s3275_sa1458"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="2022.3953" y="7706.2026"/> <glyph class="state variable" id="_f850173d-afe6-489d-9b2a-78bdcb695207"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="2051.143" y="7701.2026"/> </glyph> </glyph> <glyph class="macromolecule" id="s3276_sa1473"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Polynucleotide kinase 3'-phosphatase HUGO:PNKP, HGNC:9154, ENTREZ:11284, UNIPROT:Q96T60 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ MODULE:BER Maps_Modules_end References_begin: PMID:20691907 For C_NHEJ PMID:17638872, PMID:15385968, PMID:12032095 For BER PMID:11163244, PMID:19546231 References_end</body> </html> </notes> <label text="PNK*"/> <bbox w="80.0" h="40.0" x="2107.4722" y="7705.7847"/> </glyph> <glyph class="macromolecule" id="s3277_sa1560"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1 PMID:21270334 PARPs in cellular functions PMID:22713970 PARP1 in chromatin remodeling PMID:22469522, PMID:22713970 PARP1 initiating A_NHEJ (alt_NHEJ) PMID:24050180 PMID:19364882 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743 PMID:22743550 PMID:23562323 PMID:24210699 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 PMID:23145148 PMID:23568489 References_end</body> </html> </notes> <label text="PARP1"/> <bbox w="79.0" h="40.0" x="2019.9133" y="7752.1743"/> <glyph class="state variable" id="_963e9d5f-16d0-41bb-9baa-c62ba8bd5b1d"> <state value="?" variable="PolyADPribose"/> <bbox w="79.0" h="10.0" x="2015.5825" y="7747.1743"/> </glyph> <glyph class="state variable" id="_748b2705-80be-49c8-87b9-0557ec004906"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2091.4133" y="7767.1743"/> </glyph> <glyph class="state variable" id="_b6bd855d-ecbb-4ef3-9958-3fb081bcd01b"> <state value="" variable="Ser786"/> <bbox w="40.0" h="10.0" x="2008.6057" y="7787.1743"/> </glyph> <glyph class="state variable" id="_b5aa0fb0-481d-454c-9578-dff6e75d36e8"> <state value="" variable="Ser782"/> <bbox w="40.0" h="10.0" x="1999.9133" y="7771.404"/> </glyph> <glyph class="state variable" id="_1317420f-e63b-4539-b971-78adc0eb6dcd"> <state value="" variable="Ser785"/> <bbox w="40.0" h="10.0" x="1999.9133" y="7781.1055"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3279_csa269" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PARP2:PNK*:POLB:WRN:XRCC1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:19748837, PMID:12637553, PMID:10858306, PMID:11948190, PMID:16442856, PMID:18398454, PMID:16449207 PARP1 and PARP2 in BER PMID:22713970, PMID:22469522 References_end</body> </html> </notes> <label text="PARP2/POLB/PNK*/XRCC1/WRN"/> <bbox w="203.0" h="184.0" x="2008.4722" y="7503.3564"/> <glyph class="macromolecule" id="s3268_sa1555"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PolB, polymerase (DNA directed), beta HUGO:POLB, HGNC:9174, ENTREZ:5423, UNIPROT:P06746 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs PMID:20510258, PMID:21251944 References_end</body> </html> </notes> <label text="POLB"/> <bbox w="80.0" h="40.0" x="2109.9722" y="7564.8564"/> </glyph> <glyph class="macromolecule" id="s3269_sa1556"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: XRCC1 , X-ray repair complementing defective repair in Chinese hamster cells 1 HUGO:XRCC1, HGNC:12828, ENTREZ:7515, UNIPROT:P18887 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:NER Maps_Modules_end References_begin: PMID:20211143, PMID:8978692, PMID:8264637, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20227374 For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ): PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <label text="XRCC1"/> <bbox w="80.0" h="40.0" x="2022.0171" y="7614.3022"/> <glyph class="state variable" id="_106bb708-d915-491b-ae2e-bf184b471987"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2071.0857" y="7609.3022"/> </glyph> </glyph> <glyph class="macromolecule" id="s3270_sa1558"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <bbox w="80.0" h="40.0" x="2021.3953" y="7518.2026"/> <glyph class="state variable" id="_f5ac66ab-b3ef-4fe3-abe2-e449720fa828"> <state value="Ac" variable=""/> <bbox w="20.0" h="10.0" x="2050.143" y="7513.2026"/> </glyph> </glyph> <glyph class="macromolecule" id="s3271_sa1559"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Polynucleotide kinase 3'-phosphatase HUGO:PNKP, HGNC:9154, ENTREZ:11284, UNIPROT:Q96T60 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ MODULE:BER Maps_Modules_end References_begin: PMID:20691907 For C_NHEJ PMID:17638872, PMID:15385968, PMID:12032095 For BER PMID:11163244, PMID:19546231 References_end</body> </html> </notes> <label text="PNK*"/> <bbox w="80.0" h="40.0" x="2106.4722" y="7517.7847"/> </glyph> <glyph class="macromolecule" id="s3278_sa1561"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 2 HUGO:PARP2, HGNC:272, ENTREZ:10038, Q9UGN5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce PMID:22921416 PARPs in cellular functions PMID:22713970 PARP1 and PARP2 in HR and in inhibition of C_NHEJ PMID:22469522, PMID:196269035 PARP2 in chromatin remodeling PMID:22469522, PMID:22713970 References_end</body> </html> </notes> <label text="PARP2"/> <bbox w="80.0" h="40.0" x="2019.1085" y="7563.9927"/> <glyph class="state variable" id="_6dbb9760-0ffa-48dd-b365-45db941ef4b5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2091.6084" y="7578.2725"/> </glyph> <glyph class="state variable" id="_07f7e17b-6c74-4212-af04-d67365f81ef2"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="2049.0178" y="7558.9927"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1245_csa74" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:POLH:REV1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535 References_end</body> </html> </notes> <label text="PCNA/POLH"/> <bbox w="103.0" h="160.0" x="9559.473" y="6914.3564"/> <glyph class="macromolecule" id="s1247_sa679"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), eta HUGO:POLH, HGNC:9181, ENTREZ:5429, UNIPROT:Q9Y253 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to the Y-family polymerases PMID:19258535 POLH participates in the D-loop formation in HR PMID:16337602, PMID:16337601 Bypasses thymidine-thymidine (T-T) cyclobutane pyrimidine dimer (CPD) very accurately PMID:15189446 Cisplatin tolerance in cells with active POLH PMID:22562137 References_end</body> </html> </notes> <label text="POLH"/> <bbox w="80.0" h="40.0" x="9570.473" y="6967.3564"/> </glyph> <glyph class="macromolecule" id="s1246_sa680"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="9570.508" y="6924.4297"/> <glyph class="state variable" id="_7c7c413f-79f2-4cad-a1db-8a200cb8d1fd"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9559.491" y="6919.4297"/> </glyph> <glyph class="state variable" id="_175eff94-170f-4121-af64-8d56f7f03481"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9550.508" y="6939.4297"/> </glyph> <glyph class="state variable" id="_24cebfdc-ebea-45dc-b023-e0a93a815a4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9588.939" y="6959.4297"/> </glyph> <glyph class="state variable" id="_9be31db3-760c-4ab2-b49a-c772b19e333f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9565.508" y="6959.4297"/> </glyph> <glyph class="state variable" id="_0e32d68f-c4a9-4a14-86fd-22874b6ff0bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9605.508" y="6959.4297"/> </glyph> </glyph> <glyph class="macromolecule" id="s1551_sa681"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9570.329" y="7009.3564"/> <glyph class="state variable" id="_456bb481-3770-45ee-a8bc-0741a84c31fc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9645.329" y="7044.3564"/> </glyph> <glyph class="state variable" id="_7c5fcd4a-873d-46ca-a117-c21959894c4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9645.329" y="7024.3564"/> </glyph> <glyph class="state variable" id="_61e9c955-ba62-43fa-8928-b7b67718aeb6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9645.329" y="7004.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1249_csa75" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:POLI:REV1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535 References_end</body> </html> </notes> <label text="PCNA/POLI"/> <bbox w="100.0" h="169.0" x="9976.473" y="7056.3564"/> <glyph class="macromolecule" id="s1248_sa682"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) iota HUGO:POLI, HGNC:9182, ENTREZ:11201, UNIPROT:Q9UNA4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to the Y-family polymerases PMID:19258535 Bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta PMID:15189446, PMID:12466554 References_end</body> </html> </notes> <label text="POLI"/> <bbox w="80.0" h="40.0" x="9983.473" y="7108.3564"/> </glyph> <glyph class="macromolecule" id="s1250_sa683"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="9985.508" y="7063.4297"/> <glyph class="state variable" id="_608909bc-587f-42e6-b949-2600b225d62b"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9974.491" y="7058.4297"/> </glyph> <glyph class="state variable" id="_0a1f9e0e-e2fb-4462-8559-597a617e244d"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9965.508" y="7078.4297"/> </glyph> <glyph class="state variable" id="_336672fe-5c1c-4187-8415-089838f5e897"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10003.939" y="7098.4297"/> </glyph> <glyph class="state variable" id="_e6170cf3-693a-41fa-87be-29fc2fde4fd2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9980.508" y="7098.4297"/> </glyph> <glyph class="state variable" id="_bd633acc-065f-4fbc-b012-7b44cdf2001a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10020.508" y="7098.4297"/> </glyph> </glyph> <glyph class="macromolecule" id="s1550_sa684"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9983.473" y="7147.3564"/> <glyph class="state variable" id="_ef9c9279-dd67-4e49-8776-726ab288e93c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10058.473" y="7182.3564"/> </glyph> <glyph class="state variable" id="_e269dc89-2d5f-4515-b1f0-f6c46cb20000"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10058.473" y="7162.3564"/> </glyph> <glyph class="state variable" id="_8ad15e35-bfd6-42c7-95e8-6d4b14303ae0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10058.473" y="7142.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1241_csa73" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:POLK:REV1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535 References_end</body> </html> </notes> <label text="PCNA/POLK"/> <bbox w="108.0" h="153.0" x="9563.473" y="6751.3564"/> <glyph class="macromolecule" id="s1243_sa676"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="9576.508" y="6804.4297"/> <glyph class="state variable" id="_39b24d5a-6b0b-4efc-a3a7-ae95f920c5ee"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9565.491" y="6799.4297"/> </glyph> <glyph class="state variable" id="_a2b38983-65db-44da-9163-17845729afc1"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9556.508" y="6819.4297"/> </glyph> <glyph class="state variable" id="_08921607-64ff-4df3-b342-3144082ed643"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9594.939" y="6839.4297"/> </glyph> <glyph class="state variable" id="_ef15dd26-5c42-4935-9048-c00ff1377ec1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9571.508" y="6839.4297"/> </glyph> <glyph class="state variable" id="_d8235796-85eb-4ee3-90bd-8d2e8a546077"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9611.508" y="6839.4297"/> </glyph> </glyph> <glyph class="macromolecule" id="s1242_sa677"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) kappa HUGO:POLK, HGNC:9183, ENTREZ:51426, UNIPROT:Q96Q87 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:NER Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to Y-family polymerases PMID:19258535 Bypasses benzo(a)pyrene (B(a)P) adducts on guanine (dG-n2-BPDE adducts) PMID:15189466 For NER pathway PMID:20227374 References_end</body> </html> </notes> <label text="POLK"/> <bbox w="80.0" h="40.0" x="9574.473" y="6843.3564"/> </glyph> <glyph class="macromolecule" id="s1549_sa678"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9575.329" y="6758.0703"/> <glyph class="state variable" id="_fba29841-493c-4e46-b7a8-506dd9fca023"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9650.329" y="6793.0703"/> </glyph> <glyph class="state variable" id="_4b672f32-1302-4209-9247-66cc181b9d4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9650.329" y="6773.0703"/> </glyph> <glyph class="state variable" id="_bb0a9503-91d4-49a5-b179-5d7cfac688dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9650.329" y="6753.0703"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3398_csa72" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:POLZ* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535 References_end</body> </html> </notes> <label text="PCNA/POLZ*"/> <bbox w="100.0" h="114.0" x="9561.473" y="7091.3564"/> <glyph class="macromolecule" id="s1238_sa673"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV3-like, catalytic subunit of DNA polymerase zeta (yeast) HUGO:REV3L, HGNC:9968, ENTREZ:5980, UNIPROT:O60673 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: Related to the B-family polymerases. The first subunit of the Pol zeta complex (the second subunit is REV7) PMID:19686080, PMID:19622404, PMID:18931676 PMID:23065650 References_end</body> </html> </notes> <label text="POLZ*"/> <bbox w="80.0" h="40.0" x="9571.988" y="7139.837"/> </glyph> <glyph class="macromolecule" id="s1239_sa674"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="9574.508" y="7098.4297"/> <glyph class="state variable" id="_2f379653-951c-480b-9b93-7830a3e96a12"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9563.491" y="7093.4297"/> </glyph> <glyph class="state variable" id="_2498c6f9-537a-4c90-9c47-e628ac48b9af"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9554.508" y="7113.4297"/> </glyph> <glyph class="state variable" id="_5c8b3e7d-1f20-483b-b69b-c312d4199f91"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9592.939" y="7133.4297"/> </glyph> <glyph class="state variable" id="_2e6d618e-6d6e-4a60-8a01-0810b5d9aefc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9569.508" y="7133.4297"/> </glyph> <glyph class="state variable" id="_3d9796d6-9ecd-4010-99c2-9ec61ed5704d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9609.508" y="7133.4297"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1234_csa71" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:REV1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:19258535 References_end</body> </html> </notes> <label text="PCNA/REV1"/> <bbox w="100.0" h="120.0" x="9553.473" y="6489.3564"/> <glyph class="macromolecule" id="s1236_sa671"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="9561.901" y="6496.779"/> <glyph class="state variable" id="_96a18e60-4ddb-4504-836b-d36df4f8ab5f"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9550.885" y="6491.779"/> </glyph> <glyph class="state variable" id="_d44ec410-7cf8-4fa5-8403-7bca8cf0accb"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9541.901" y="6511.779"/> </glyph> <glyph class="state variable" id="_626a428d-d1fb-453e-8ad4-52abb52f5764"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9580.333" y="6531.779"/> </glyph> <glyph class="state variable" id="_5a03fcbc-a46a-485c-9918-ab677532de03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9556.901" y="6531.779"/> </glyph> <glyph class="state variable" id="_37cce160-60c4-4b64-aaa3-829e7ed75556"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9596.901" y="6531.779"/> </glyph> </glyph> <glyph class="macromolecule" id="s1235_sa672"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9564.988" y="6542.837"/> <glyph class="state variable" id="_4818a987-0df8-40db-9b93-a6defd45c8d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9639.988" y="6577.837"/> </glyph> <glyph class="state variable" id="_d16dc388-f7b9-44cd-bcb8-2509645dbaf0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9639.988" y="6557.837"/> </glyph> <glyph class="state variable" id="_d8027077-356f-4fc6-bb8c-963ccd9ad261"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9639.988" y="6537.837"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s593_csa15" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:POLD*:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="POLD*/RPA1/RPA2/RPA3"/> <bbox w="96.0" h="211.0" x="3932.4722" y="7082.3564"/> <glyph class="macromolecule" id="s594_sa460"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), delta 1, catalytic subunit 125kDa HUGO:POLD1, HGNC:9175, ENTREZ:5424, UNIPROT:P28340 polymerase (DNA directed), delta 2, regulatory subunit 50kDa HUGO:POLD2, HGNC:9176, ENTREZ:5425, UNIPROT:P49005 polymerase (DNA-directed), delta 3, accessory subunit HUGO:POLD3, HGNC:20932, ENTREZ:10714, UNIPROT:Q15054 polymerase (DNA-directed), delta 4 HUGO:POLD4, HGNC:14106, ENTREZ:57804, UNIPROT:Q9HCU8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:A_NHEJ Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20478261 For A_NHEJ PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 References_end</body> </html> </notes> <label text="POLD*"/> <bbox w="80.0" h="40.0" x="3940.6875" y="7097.125"/> </glyph> <glyph class="macromolecule" id="s2753_sa461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="3939.4624" y="7225.32"/> </glyph> <glyph class="macromolecule" id="s2754_sa462"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="3938.1235" y="7182.114"/> <glyph class="state variable" id="_f5086f11-6635-47be-a130-a93494dfbdb2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3930.6235" y="7197.114"/> </glyph> </glyph> <glyph class="macromolecule" id="s2755_sa463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="3937.7861" y="7142.606"/> </glyph> </glyph> <glyph class="complex" id="s1553_csa93" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:POLH:RAD18:RAD6*:REV1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:TLS Maps_Modules_end</body> </html> </notes> <label text="POLH/RAD6*/RAD18/REV1"/> <bbox w="192.0" h="117.0" x="9471.473" y="6622.3564"/> <glyph class="macromolecule" id="s1557_sa722"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed), eta HUGO:POLH, HGNC:9181, ENTREZ:5429, UNIPROT:Q9Y253 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 Related to the Y-family polymerases PMID:19258535 POLH participates in the D-loop formation in HR PMID:16337602, PMID:16337601 Bypasses thymidine-thymidine (T-T) cyclobutane pyrimidine dimer (CPD) very accurately PMID:15189446 Cisplatin tolerance in cells with active POLH PMID:22562137 References_end</body> </html> </notes> <label text="POLH"/> <bbox w="80.0" h="40.0" x="9570.187" y="6632.3564"/> </glyph> <glyph class="macromolecule" id="s1558_sa723"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <bbox w="80.0" h="40.0" x="9570.187" y="6673.0703"/> <glyph class="state variable" id="_5ae3c5d0-741b-4327-8698-9e7061c5e53b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9645.187" y="6708.0703"/> </glyph> <glyph class="state variable" id="_3bdc3271-f643-44ea-869d-bab9b780a1ff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9645.187" y="6688.0703"/> </glyph> <glyph class="state variable" id="_863849e7-6c7e-4b41-9e21-dabb6d915bfa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9645.187" y="6668.0703"/> </glyph> </glyph> <glyph class="macromolecule" id="s2790_sa724"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A (RAD6 homolog) HUGO:UBE2A, HGNC:12472, ENTREZ:7319, UNIPROT:P49459 ubiquitin-conjugating enzyme E2B (RAD6 homolog) HUGO:UBE2B, HGNC:12473, ENTREZ:7320, UNIPROT:P63146 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 In complex with RAD18 ubiquitinates PCNA at Lys164 making PCNA specific for TLS DNA repair activation PMID:19258535 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="9480.116" y="6673.3506"/> </glyph> <glyph class="macromolecule" id="s2791_sa725"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD18 homolog (S. cerevisiae) HUGO:RAD18, HGNC:18278, ENTREZ:56852, UNIPROT:Q9NS91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: Rad 18 in complex with UBE2B (or UBE2A) ubiquitinates PCNA that maked PCNA available to TLS pathway specifically PMID:20129063 RAD18 is a E3 ligase PMID:10884424, PMID:18363965, PMID:19013543, PMID:16611994, PMID:19396164, PMID:19258535, PMID:20675655, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="RAD18"/> <bbox w="80.0" h="40.0" x="9481.116" y="6631.3506"/> </glyph> </glyph> <glyph class="complex" id="s1421_csa88" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HEL308*:POLN Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="POLN/HEL308*"/> <bbox w="100.0" h="120.0" x="7001.472" y="7672.3564"/> <glyph class="macromolecule" id="s1423_sa711"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: helicase, POLQ-like HUGO:HELQ, HGNC:18536, ENTREZ:113510, UNIPROT:Q8TDG4 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:20122407, PMID:20493853, PMID:21195035 References_end</body> </html> </notes> <label text="HEL308*"/> <bbox w="80.0" h="40.0" x="7008.615" y="7682.7847"/> </glyph> <glyph class="macromolecule" id="s1422_sa712"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (DNA directed) nu HUGO:POLN, HGNC:18870, ENTREZ:353497, UNIPROT:Q7Z5Q5 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:A_NHEJ MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: For HR PMID:19772495, PMID:16697054, PMID:19847258 For A_NHEJ PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292 Complex PolN:HEL308 participates in HR and in Fanconi pathways PMID:19995904 References_end</body> </html> </notes> <label text="POLN"/> <bbox w="80.0" h="40.0" x="7008.615" y="7727.7847"/> </glyph> </glyph> <glyph class="complex" id="s2932_csa250" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP5C:RAD17 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end</body> </html> </notes> <label text="PP5*/RAD17"/> <bbox w="100.0" h="120.0" x="6159.472" y="3152.3562"/> <glyph class="macromolecule" id="s2934_sa1318"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD17 homolog (S. pombe) HUGO:RAD17, HGNC:9807, ENTREZ:5884, UNIPROT:O75943 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:16885023, PMID:17303408 References_end</body> </html> </notes> <label text="RAD17"/> <bbox w="80.0" h="40.0" x="6171.778" y="3161.736"/> <glyph class="state variable" id="_fc770348-8b5d-4fd9-bebc-5fdfcee1d34f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6166.778" y="3176.736"/> </glyph> </glyph> <glyph class="macromolecule" id="s2933_sa1319"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein phosphatase 5, catalytic subunit HUGO:PPP5C, HGNC:9322, ENTREZ:5536, UNIPROT:P53041 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:16260606, PMID:14871926 References_end</body> </html> </notes> <label text="PPP5C"/> <bbox w="80.0" h="40.0" x="6170.778" y="3204.736"/> </glyph> </glyph> <glyph class="complex" id="s765_csa26" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RAD23*:TDG:XPC Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768 References_end</body> </html> </notes> <label text="RAD23*/TDG/XPC"/> <bbox w="115.0" h="158.0" x="3141.4722" y="6727.3564"/> <glyph class="macromolecule" id="s766_sa489"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: xeroderma pigmentosum, complementation group C HUGO:XPC, HGNC:12816, ENTREZ:7508, UNIPROT:Q01831 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:20211143, PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="XPC"/> <bbox w="80.0" h="40.0" x="3156.6802" y="6740.8057"/> </glyph> <glyph class="macromolecule" id="s832_sa490"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD23 homolog A (S. cerevisiae) HUGO:RAD23A, HGNC:9812, ENTREZ:5886, UNIPROT:P54725 RAD23 homolog B HUGO:RAD23B, HGNC:9813, ENTREZ:5887, UNIPROT:P54727 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 References_end</body> </html> </notes> <label text="RAD23*"/> <bbox w="80.0" h="40.0" x="3156.6802" y="6820.8057"/> </glyph> <glyph class="macromolecule" id="s768_sa491"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thymine-DNA glycosylase HUGO:TDG, HGNC:11700, ENTREZ:6996, UNIPROT:Q13569 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER Maps_Modules_end References_begin: PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="TDG"/> <bbox w="80.0" h="40.0" x="3157.6802" y="6780.8057"/> <glyph class="state variable" id="_eba013e1-b46c-402d-a12a-642a2a49d2c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3152.6802" y="6787.5215"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1072_csa53" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RAD51:XRCC2:XRCC3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="RAD51/XRCC2/XRCC3"/> <bbox w="118.0" h="170.0" x="7543.472" y="7145.3564"/> <glyph class="macromolecule" id="s1073_sa598"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51A HUGO:RAD51, HGNC:9817, ENTREZ:5888, UNIPROT:Q06609 RAD51-like 1 (S. cerevisiae), RAD51B HUGO:RAD51L1, HGNC:9822, ENTREZ:5890, UNIPROT:Q86U92 RAD51 homolog C (S. cerevisiae) HUGO:RAD51C, HGNC:9820, ENTREZ:5889, UNIPROT:O43502 RAD51-like 3 (S. cerevisiae), RAD51D HUGO:RAD51L3, HGNC:9823, ENTREZ:5892, UNIPROT:O94908 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:G2_M_CHECKPOINT MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="80.0" h="40.0" x="7560.3306" y="7165.252"/> </glyph> <glyph class="macromolecule" id="s1075_sa599"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 2 HUGO:XRCC2, HGNC:12829, ENTREZ:7516, UNIPROT:O43543 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC2"/> <bbox w="80.0" h="40.0" x="7560.3306" y="7208.252"/> </glyph> <glyph class="macromolecule" id="s1077_sa600"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 3 HUGO:XRCC3, HGNC:12830, ENTREZ:7517, UNIPROT:O43542 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="XRCC3"/> <bbox w="80.0" h="40.0" x="7560.3306" y="7250.252"/> </glyph> </glyph> <glyph class="complex" id="s1587_csa94" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RAD52:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:11571269, PMID:20081207 References_end</body> </html> </notes> <label text="RAD52/RPA1/RPA2/RPA3"/> <bbox w="107.0" h="195.0" x="4828.472" y="6811.3564"/> <glyph class="macromolecule" id="s1589_sa726"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD52 homolog (S. cerevisiae) HUGO:RAD52, HGNC:9824, ENTREZ:5893, UNIPROT:P43351 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For SSA pathway PMID:19473888, PMID:12947387 RAD52 in SSA pathway is acting as RAD51 in HR. RAD52 is a key factor initating SSA pathway PMID:11571269, PMID:20081207 References_end</body> </html> </notes> <label text="RAD52"/> <bbox w="80.0" h="40.0" x="4840.0435" y="6940.0703"/> </glyph> <glyph class="macromolecule" id="s2782_sa727"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="4840.5435" y="6815.0703"/> </glyph> <glyph class="macromolecule" id="s2781_sa728"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="4839.5435" y="6889.0703"/> </glyph> <glyph class="macromolecule" id="s2780_sa729"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="4840.2046" y="6848.8647"/> <glyph class="state variable" id="_1f177907-002a-45ae-bf3f-a178649b15d9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4832.7046" y="6863.8647"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s740_csa70" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RAD18:RAD6* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end</body> </html> </notes> <label text="RAD6*/RAD18"/> <bbox w="102.0" h="125.0" x="9710.473" y="6569.3564"/> <glyph class="macromolecule" id="s737_sa669"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD18 homolog (S. cerevisiae) HUGO:RAD18, HGNC:18278, ENTREZ:56852, UNIPROT:Q9NS91 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: Rad 18 in complex with UBE2B (or UBE2A) ubiquitinates PCNA that maked PCNA available to TLS pathway specifically PMID:20129063 RAD18 is a E3 ligase PMID:10884424, PMID:18363965, PMID:19013543, PMID:16611994, PMID:19396164, PMID:19258535, PMID:20675655, PMID:18196958, PMID:17652783 References_end</body> </html> </notes> <label text="RAD18"/> <bbox w="80.0" h="40.0" x="9721.401" y="6582.779"/> </glyph> <glyph class="macromolecule" id="s1270_sa670"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A (RAD6 homolog) HUGO:UBE2A, HGNC:12472, ENTREZ:7319, UNIPROT:P49459 ubiquitin-conjugating enzyme E2B (RAD6 homolog) HUGO:UBE2B, HGNC:12473, ENTREZ:7320, UNIPROT:P63146 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:TLS Maps_Modules_end References_begin: PMID:18196958, PMID:17652783 In complex with RAD18 ubiquitinates PCNA at Lys164 making PCNA specific for TLS DNA repair activation PMID:19258535 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="9719.401" y="6631.779"/> </glyph> </glyph> <glyph class="complex" id="s1000_csa50" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RPA1:RPA2:RPA3:SMARCAL1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination PMID:19841479, PMID:19793861, PMID:19793862 References_end</body> </html> </notes> <label text="RPA complex:SMARCAL1"/> <bbox w="146.0" h="200.0" x="7073.472" y="6637.3564"/> <glyph class="macromolecule" id="s2736_sa591"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="7101.2134" y="6641.6147"/> </glyph> <glyph class="macromolecule" id="s2737_sa592"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="7101.2134" y="6684.6147"/> <glyph class="state variable" id="_3998e243-8034-447d-81d6-5bde59d695eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7096.2134" y="6699.6147"/> </glyph> </glyph> <glyph class="macromolecule" id="s2735_sa593"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="7100.2134" y="6729.6147"/> </glyph> <glyph class="macromolecule" id="s3043_sa1401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 HUGO:SMARCAL1, HGNC:11102, ENTREZ:50485, UNIPROT:Q9NZC9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR MODULE:FANCONI Maps_Modules_end References_begin: PMID:19841479 For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination PMID:19841479, PMID:19793861, PMID:19793862 References_end</body> </html> </notes> <label text="SMARCAL1"/> <bbox w="80.0" h="40.0" x="7101.6157" y="6773.2837"/> <glyph class="state variable" id="_5782b875-003f-4280-b3ea-7fdcb31df7ac"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7094.1157" y="6788.252"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s3289_csa41" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="RPA1/RPA2/RPA3"/> <bbox w="112.0" h="141.0" x="5013.472" y="6826.3564"/> <glyph class="macromolecule" id="s3290_sa559"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="5028.972" y="6831.3564"/> </glyph> <glyph class="macromolecule" id="s3291_sa560"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="5027.972" y="6905.3564"/> </glyph> <glyph class="macromolecule" id="s652_sa561"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="5028.6333" y="6865.1504"/> <glyph class="state variable" id="_796ec001-6d3f-4909-9df1-89e1173daafc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5021.1333" y="6880.1504"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s833_csa22" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RPA1:RPA2:RPA3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:MMR Maps_Modules_end</body> </html> </notes> <label text="RPA1/RPA2/RPA3"/> <bbox w="113.0" h="146.0" x="7336.472" y="6732.3564"/> <glyph class="macromolecule" id="s294_sa476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <bbox w="80.0" h="40.0" x="7351.5884" y="6735.365"/> </glyph> <glyph class="macromolecule" id="s676_sa477"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <bbox w="80.0" h="40.0" x="7351.5884" y="6777.365"/> <glyph class="state variable" id="_c0f94412-1532-4d86-b5d5-ef6bc97d8838"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7346.5884" y="6792.365"/> </glyph> </glyph> <glyph class="macromolecule" id="s292_sa478"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <bbox w="80.0" h="40.0" x="7351.5884" y="6817.365"/> </glyph> </glyph> <glyph class="complex" id="s3308_csa244" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SCC1*:SMC1*:SMC3:STAG* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_M_CHECKPOINT MODULE:M_CC_PHASE Maps_Modules_end References_begin: Phosphorylated by ATM PMID:11076961, PMID:12200439 References_end</body> </html> </notes> <label text="SCC1*/SMC1*/SMC3/STAG*"/> <bbox w="184.0" h="139.0" x="5287.472" y="4430.3564"/> <glyph class="macromolecule" id="s2903_sa1293"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 1A HUGO:SMC1A , HGNC:11111, ENTREZ:8243, UNIPROT:Q14683 structural maintenance of chromosomes 1B HUGO:SMC1B , HGNC:11112, ENTREZ:27127 UNIPROT:Q8NDV3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC1*"/> <bbox w="80.0" h="40.0" x="5295.942" y="4447.6763"/> <glyph class="state variable" id="_87e0a827-b80c-433a-a006-3e77190e8886"> <state value="" variable="S966"/> <bbox w="30.0" h="10.0" x="5303.188" y="4442.6763"/> </glyph> <glyph class="state variable" id="_7de7fd25-d5b2-44e4-812f-549d6a480025"> <state value="P" variable="S957"/> <bbox w="35.0" h="10.0" x="5329.956" y="4442.6763"/> </glyph> </glyph> <glyph class="macromolecule" id="s2902_sa1294"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Structural maintenance of chromosomes 3 HUGO:SMC3, HGNC:2468, ENTREZ:9126, UNIPROT:Q9UQE7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC3"/> <bbox w="80.0" h="40.0" x="5296.942" y="4502.6763"/> <glyph class="state variable" id="_85799018-4064-4662-8fc0-54741e7ebf6e"> <state value="P" variable="S1083"/> <bbox w="40.0" h="10.0" x="5329.8364" y="4497.6763"/> </glyph> </glyph> <glyph class="macromolecule" id="s3309_sa1295"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: stromal antigen 1 HUGO:STAG1, HGNC:11354, ENTREZ:10274, UNIPROT:Q8WVM7 stromal antigen 2 HUGO:STAG2, HGNC:11355, ENTREZ:10735, UNIPROT:Q8N3U4 stromal antigen 3 HUGO:STAG3, HGNC:11356, ENTREZ:10734, UNIPROT:Q9UJ98 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:CELL_CYCLE MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:11076961 References_end</body> </html> </notes> <label text="STAG*"/> <bbox w="80.0" h="40.0" x="5382.482" y="4504.39"/> <glyph class="state variable" id="_eb375548-f7a5-4885-8d9a-9b08dca4205a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5457.482" y="4519.39"/> </glyph> </glyph> <glyph class="macromolecule" id="s2901_sa1296"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD21 homolog (S. pombe), hHR21, SCC1 HUGO:RAD21, HGNC:9811, ENTREZ:5885, UNIPROT:O60216 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:1159013 References_end</body> </html> </notes> <label text="SCC1*"/> <bbox w="80.0" h="40.0" x="5382.482" y="4460.39"/> <glyph class="state variable" id="_140c62d7-2c3a-4fbd-a976-a62502450c2c"> <state value="P" variable="ATM-dep."/> <bbox w="55.0" h="10.0" x="5354.982" y="4475.3584"/> </glyph> <glyph class="state variable" id="_02a0fd99-17e6-4589-a7a1-1702c010d4dd"> <state value="" variable="PLK1-dep."/> <bbox w="55.0" h="10.0" x="5434.982" y="4475.39"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2900_csa239" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SCC1*:SMC1*:SMC3:STAG* Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:G2_M_CHECKPOINT MODULE:M_CC_PHASE Maps_Modules_end References_begin: Phosphorylated by ATM PMID:11076961, PMID:12200439 References_end</body> </html> </notes> <label text="SCC1*/SMC1*/SMC3/STAG*"/> <bbox w="176.0" h="118.0" x="5562.472" y="4437.3564"/> <glyph class="macromolecule" id="s2880_sa1271"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 1A HUGO:SMC1A , HGNC:11111, ENTREZ:8243, UNIPROT:Q14683 structural maintenance of chromosomes 1B HUGO:SMC1B , HGNC:11112, ENTREZ:27127 UNIPROT:Q8NDV3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC1*"/> <bbox w="80.0" h="40.0" x="5568.9326" y="4449.6426"/> <glyph class="state variable" id="_5c5ab161-8e41-473a-b866-ed900302d516"> <state value="" variable="S966"/> <bbox w="30.0" h="10.0" x="5576.1787" y="4444.6426"/> </glyph> <glyph class="state variable" id="_e2726e52-d518-4018-9f04-d3615f2e090e"> <state value="" variable="S957"/> <bbox w="30.0" h="10.0" x="5605.447" y="4444.6426"/> </glyph> </glyph> <glyph class="macromolecule" id="s2879_sa1272"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Structural maintenance of chromosomes 3 HUGO:SMC3, HGNC:2468, ENTREZ:9126, UNIPROT:Q9UQE7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC3"/> <bbox w="80.0" h="40.0" x="5568.9326" y="4491.6426"/> <glyph class="state variable" id="_ff0a61fa-f8eb-430b-ac66-3bf603d4ecfb"> <state value="" variable="S1083"/> <bbox w="35.0" h="10.0" x="5604.327" y="4486.6426"/> </glyph> </glyph> <glyph class="macromolecule" id="s2904_sa1273"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: stromal antigen 1 HUGO:STAG1, HGNC:11354, ENTREZ:10274, UNIPROT:Q8WVM7 stromal antigen 2 HUGO:STAG2, HGNC:11355, ENTREZ:10735, UNIPROT:Q8N3U4 stromal antigen 3 HUGO:STAG3, HGNC:11356, ENTREZ:10734, UNIPROT:Q9UJ98 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:CELL_CYCLE MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:11076961 References_end</body> </html> </notes> <label text="STAG*"/> <bbox w="80.0" h="40.0" x="5650.472" y="4490.3564"/> <glyph class="state variable" id="_dfcfe88e-887f-4be9-89b4-f8b5c87672b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5725.472" y="4505.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2877_sa1275"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAD21 homolog (S. pombe), hHR21, SCC1 HUGO:RAD21, HGNC:9811, ENTREZ:5885, UNIPROT:O60216 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:15459660, PMID:1159013 References_end</body> </html> </notes> <label text="SCC1*"/> <bbox w="80.0" h="40.0" x="5653.472" y="4448.3564"/> <glyph class="state variable" id="_1b659b45-f47a-4b8d-8559-b9485c6b2dad"> <state value="" variable="ATM-dep."/> <bbox w="50.0" h="10.0" x="5628.472" y="4463.3247"/> </glyph> <glyph class="state variable" id="_fa479b1f-7553-48cf-a161-6304ce2ae109"> <state value="" variable="PLK1-dep."/> <bbox w="55.0" h="10.0" x="5705.972" y="4463.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1596_csa96" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SLX1*:SLX4* Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="SLX1*/SLX4*"/> <bbox w="100.0" h="116.0" x="4867.472" y="7318.3564"/> <glyph class="macromolecule" id="s1597_sa733"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GIY-YIG domain containing 1 HUGO:SLX1A, HGNC:20922, ENTREZ:548593, UNIPROT:Q9BQ83 GIY-YIG domain containing 2 GIYD2, HGNC:28748, ENTREZ:79008, UNIPROT:Q9BQ83 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236 References_end</body> </html> </notes> <label text="SLX1*"/> <bbox w="80.0" h="40.0" x="4878.472" y="7328.2134"/> </glyph> <glyph class="macromolecule" id="s1598_sa734"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BTB (POZ) domain containing 12 Structure-specific endonuclease subunit SLX4 HUGO:BTBD12, HGNC:23845, ENTREZ:84464, UNIPROT:Q8IY92 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:SSA Maps_Modules_end References_begin: PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236, PMID:22101340 References_end</body> </html> </notes> <label text="SLX4*"/> <bbox w="80.0" h="40.0" x="4882.472" y="7370.2134"/> </glyph> </glyph> <glyph class="complex" id="s2895_csa242" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SMC1*:SMC3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="SMC1*/SMC3"/> <bbox w="100.0" h="120.0" x="7081.472" y="5382.3564"/> <glyph class="macromolecule" id="s2897_sa1291"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Structural maintenance of chromosomes 3 HUGO:SMC3, HGNC:2468, ENTREZ:9126, UNIPROT:Q9UQE7 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC3"/> <bbox w="80.0" h="40.0" x="7090.472" y="5439.3564"/> <glyph class="state variable" id="_f24524a1-e0a2-42c2-ab86-5869ff7b693a"> <state value="P" variable="S1083"/> <bbox w="40.0" h="10.0" x="7123.3667" y="5434.3564"/> </glyph> </glyph> <glyph class="macromolecule" id="s2898_sa1292"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 1A HUGO:SMC1A , HGNC:11111, ENTREZ:8243, UNIPROT:Q14683 structural maintenance of chromosomes 1B HUGO:SMC1B , HGNC:11112, ENTREZ:27127 UNIPROT:Q8NDV3 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:M_CC_PHASE MODULE:HR MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 For S-phase checkpoint PMID:11877377, PMID:15459660, PMID:19793801 References_end</body> </html> </notes> <label text="SMC1*"/> <bbox w="80.0" h="40.0" x="7090.472" y="5397.3564"/> <glyph class="state variable" id="_28c34a4c-1393-4b57-ba0d-81ed2412aa47"> <state value="" variable="S966"/> <bbox w="30.0" h="10.0" x="7097.7183" y="5392.3564"/> </glyph> <glyph class="state variable" id="_5062b519-3ed1-4569-a768-29731dacc850"> <state value="P" variable="S957"/> <bbox w="35.0" h="10.0" x="7124.4863" y="5392.3564"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s1019_csa56" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SMC5:SMC6 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end</body> </html> </notes> <label text="SMC5/SMC6"/> <bbox w="100.0" h="120.0" x="7077.472" y="5241.3564"/> <glyph class="macromolecule" id="s1020_sa621"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 5 HUGO:SMC5, HGNC:20465, ENTREZ:23137, UNIPROT:Q8IY18 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="SMC5"/> <bbox w="80.0" h="40.0" x="7083.363" y="5252.038"/> </glyph> <glyph class="macromolecule" id="s1021_sa622"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: structural maintenance of chromosomes 6 HUGO:SMC6, HGNC:20466, ENTREZ:79677, UNIPROT:Q96SB8 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:HR Maps_Modules_end References_begin: PMID:19772495, PMID:16697054, PMID:19847258 References_end</body> </html> </notes> <label text="SMC6"/> <bbox w="80.0" h="40.0" x="7083.363" y="5293.038"/> </glyph> </glyph> <glyph class="complex" id="s2441_csa218" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Securin*:Separin* Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: Separin is ihibited by Securin References_end</body> </html> </notes> <label text="Securin*/Separin*"/> <bbox w="100.0" h="113.0" x="2988.4722" y="1674.3562"/> <glyph class="macromolecule" id="s2443_sa1090"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: extra spindle pole bodies homolog 1 (S. cerevisiae), Separin, Separase HUGO:ESPL1, HGNC:16856, ENTREZ:9700, UNIPROT:Q14674 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT Maps_Modules_end References_begin: PMID:12297314, PMID:17604273, PMID:19342897, PMID:20144767, PMID:19758559 References_end</body> </html> </notes> <label text="Separin*"/> <bbox w="80.0" h="40.0" x="3000.7117" y="1679.6766"/> </glyph> <glyph class="macromolecule" id="s2442_sa1091"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pituitary tumor-transforming 1, Securin HUGO:PTTG1, HGNC:9690, ENTREZ:9232, UNIPROT:O95997 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:SPINDLE_CHECKPOINT MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:17962814, PMID:11238996, PMID:20691907 References_end</body> </html> </notes> <label text="Securin*"/> <bbox w="80.0" h="40.0" x="3000.7117" y="1723.6766"/> <glyph class="state variable" id="_a9a4321a-fa05-41fa-935b-a7f7872b8de2"> <state value="" variable="S165"/> <bbox w="30.0" h="10.0" x="2997.2034" y="1718.6766"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s2976_csa259" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TIM1*:TIPIN Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 References_end</body> </html> </notes> <label text="TIM1*/TIPIN"/> <bbox w="97.0" h="115.0" x="5922.472" y="381.35626"/> <glyph class="macromolecule" id="s2978_sa1356"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TIMELESS interacting protein HUGO:TIPIN, HGNC:30750, ENTREZ:54962, UNIPROT:Q9BVW5 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIPIN"/> <bbox w="80.0" h="40.0" x="5928.4155" y="433.3222"/> </glyph> <glyph class="macromolecule" id="s2977_sa1357"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: timeless homolog (Drosophila) HUGO:TIMELESS, HGNC:11813, ENTREZ:8914, UNIPROT:Q9UNS1 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:17102137, PMID:17116885, PMID:12875843, PMID:17296725, PMID:15798197 Role of TIM/TIPIN complex in DNA replication PMID:17141802, PMID:12875843 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="TIM1*"/> <bbox w="80.0" h="40.0" x="5929.4155" y="388.3222"/> </glyph> </glyph> <glyph class="complex" id="s1289_csa77" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:UAF1*:USP1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI Maps_Modules_end References_begin: Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. 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Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end</body> </html> </notes> <label text="CDC2*/CycA*"/> <clone/> <bbox w="100.0" h="120.0" x="5741.472" y="1092.3562"/> <glyph class="macromolecule" id="s3448_sa838"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin A1 HUGO:CCNA1, HGNC:1577, ENTREZ:8900, UNIPROT:P78396 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:S_CC_PHASE Maps_Modules_end References_begin: PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786 References_end</body> </html> </notes> <label text="CyclinA1*"/> <clone/> <bbox w="80.0" h="40.0" x="5793.6646" y="1551.0828"/> </glyph> <glyph class="macromolecule" id="s3449_sa1452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <clone/> <bbox w="80.0" h="40.0" x="5182.84" y="6833.5195"/> </glyph> <glyph class="macromolecule" id="s3451_sa1625" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A1, 70kDa HUGO:RPA1, HGNC:10289, ENTREZ:6117, UNIPROT:P27694 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA1"/> <clone/> <bbox w="80.0" h="40.0" x="5793.7686" y="785.94446"/> </glyph> <glyph class="macromolecule" id="s3452_sa76" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A2, 32kDa HUGO:RPA2, HGNC:10290, ENTREZ:6118, UNIPROT:P15927 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, 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checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA2"/> <clone/> <bbox w="80.0" h="40.0" x="5615.881" y="736.7221"/> <glyph class="state variable" id="_bc9cf073-0b07-4c68-b40a-a1be5b619bda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5610.881" y="751.7221"/> </glyph> </glyph> <glyph class="macromolecule" id="s3453_sa77" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <clone/> <bbox w="80.0" h="40.0" x="5184.84" y="6924.5195"/> </glyph> <glyph class="macromolecule" id="s3453_sa1628" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: replication protein A3, 14kDa HUGO:RPA3, HGNC:10291, ENTREZ:6119, UNIPROT:P35244 Identifiers_end Maps_Modules_begin: MODULE:CELL_CYCLE MODULE:REGULATORS MODULE:DNA_REPAIR MODULE:S_PHASE_CHECKPOINT MODULE:S_CC_PHASE MODULE:HR MODULE:NER MODULE:MMR Maps_Modules_end References_begin: PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249 For S-phase checkpoint PMID:15459660,PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 References_end</body> </html> </notes> <label text="RPA3"/> <clone/> <bbox w="80.0" h="40.0" x="5702.8804" y="735.7221"/> </glyph> <glyph class="macromolecule" id="s3454_sa64" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHK1 checkpoint homolog (S. pombe) HUGO:CHEK1, HGNC:1925, ENTREZ:1111, UNIPROT:O14757 Identifiers_end Maps_Modules_begin: MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT Maps_Modules_end References_begin: For S-phase checkpoint PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase 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PMID:18677104 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 References_end</body> </html> </notes> <label text="CHEK1"/> <clone/> <bbox w="80.0" h="40.0" x="5983.88" y="4153.8335"/> <glyph class="state variable" id="_5e64b111-d2b7-4d92-ab7c-47a67c34892d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5976.38" y="4168.8335"/> </glyph> </glyph> <glyph class="simple chemical" id="s3455_sa3" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="Base"/> <clone/> <bbox w="75.0" h="22.5" x="2790.269" y="6707.5"/> </glyph> <glyph class="simple chemical" id="s3455_sa17" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="Base"/> <clone/> <bbox w="70.0" h="25.0" x="1717.269" y="6754.5"/> </glyph> <glyph class="simple chemical" id="s3456_sa15" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NER MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="dNTPs"/> <clone/> <bbox w="70.0" h="25.0" x="2820.269" y="7158.5"/> </glyph> <glyph class="simple chemical" id="s3456_sa48" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MODULE:NER MODULE:BER Maps_Modules_end</body> </html> </notes> <label text="dNTPs"/> <clone/> <bbox w="70.0" h="25.0" x="1732.269" y="7566.0"/> </glyph> <glyph class="macromolecule" id="s3457_sa50" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1, HGNC:270, ENTREZ:142, P09874 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:G1_S_CHECKPOINT MODULE:S_PHASE_CHECKPOINT MODULE:G2_M_CHECKPOINT MODULE:BER MODULE:HR MODULE:C_NHEJ MODULE:A_NHEJ Maps_Modules_end References_begin: NOTE: PARP-? poly-ADP-ribosilated PMID:22055391 PARP is active phosphorylated and poly-ADP-ribosilated form PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072 PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <clone/> <bbox w="80.0" h="40.0" x="5809.2686" y="6609.4077"/> </glyph> <glyph class="macromolecule" id="s3458_sa1596" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 6 HUGO:XRCC6, HGNC:4055, ENTREZ:2547, UNIPROT:P12956 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku70*"/> <clone/> <bbox w="80.0" h="40.0" x="5816.093" y="7596.9414"/> </glyph> <glyph class="macromolecule" id="s3459_sa121" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <clone/> <bbox w="80.0" h="40.0" x="5805.7686" y="6668.5"/> <glyph class="state variable" id="_df85c5d7-dcea-446f-8198-736f6642f221"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5824.2" y="6663.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s3459_sa1597" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) HUGO:XRCC5, HGNC:12833,ENTREZ:7520, UNIPROT:P13010 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180 Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ PMID:17088286 References_end</body> </html> </notes> <label text="Ku80*"/> <clone/> <bbox w="80.0" h="40.0" x="5905.093" y="7595.9414"/> <glyph class="state variable" id="_5141c60a-1f2b-4f2a-a3a9-bbeba2b6d827"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5923.5244" y="7590.9414"/> </glyph> </glyph> <glyph class="macromolecule" id="s3460_sa124" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <clone/> <bbox w="80.0" h="40.0" x="6071.0205" y="7384.4077"/> <glyph class="state variable" id="_f10003fe-060b-4155-86de-ba682c89dcd2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6066.0205" y="7399.4077"/> </glyph> </glyph> <glyph class="macromolecule" id="s3460_sa1609" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase, DNA-activated, catalytic polypeptide HUGO:PRKDC, HGNC:9413, ENTREZ:5591, UNIPROT:Q9UME3 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743 PMID:21300785, PMID:21175350, PMID:20691907 References_end</body> </html> </notes> <label text="DNA-PK*"/> <clone/> <bbox w="80.0" h="40.0" x="6011.1436" y="7579.0"/> <glyph class="state variable" id="_04dd1872-564a-4c6d-b8e6-752f9ec64be3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6006.1436" y="7594.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3461_sa211" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <clone/> <bbox w="80.0" h="40.0" x="8666.521" y="7340.0"/> <glyph class="state variable" id="_d028a3f3-49dd-4cef-a618-ee6b3de9784c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8741.521" y="7375.0"/> </glyph> <glyph class="state variable" id="_250db95e-0ea4-4919-b75f-4dc65562f0ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8741.521" y="7355.0"/> </glyph> <glyph class="state variable" id="_b92a101c-76fd-47b5-bfa8-f5145cdff0ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8741.521" y="7335.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s3461_sa1449" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: REV1 homolog (S. cerevisiae) HUGO:REV1, HGNC:14060, ENTREZ:51455, UNIPROT:Q9UBZ9 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:FANCONI MODULE:TLS Maps_Modules_end References_begin: PMID:23065650 Related to Y-family polymerases. For Fanconi anemia pathway PMID:19686080, PMID:19622404, PMID:18931676 For hiperphosphotyration of REV1 in cell cycle and DNA danage-dependent manner. Hyperphosphorylation makes REV1 regulatory molecule for activating TLS pathway PMID:17035102, PMID:19258535 References_end</body> </html> </notes> <label text="REV1"/> <clone/> <bbox w="80.0" h="40.0" x="9790.768" y="6989.278"/> <glyph class="state variable" id="_7f87ea95-065e-4277-9512-31cc613ba31d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9865.768" y="7024.278"/> </glyph> <glyph class="state variable" id="_6290368e-dc6a-4291-bc99-45a1f05e6e35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9865.768" y="7004.278"/> </glyph> <glyph class="state variable" id="_58567400-f507-4f6d-b595-fe15761516b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9865.768" y="6984.278"/> </glyph> </glyph> <glyph class="macromolecule" id="s3463_sa1549" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 3 HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 PARP3 in chromatin remodeling PMID:22469522, PMID:22713970 APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ PARP3 in C_NHEJ PMID:22743550 References_end</body> </html> </notes> <label text="PARP3"/> <clone/> <bbox w="80.0" h="40.0" x="2634.769" y="7602.5"/> </glyph> <glyph class="macromolecule" id="s3463_sa1581" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 3 HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 PARP3 in chromatin remodeling PMID:22469522, PMID:22713970 APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ PARP3 in C_NHEJ PMID:22743550 References_end</body> </html> </notes> <label text="PARP3"/> <clone/> <bbox w="80.0" h="40.0" x="5987.626" y="7652.2144"/> </glyph> <glyph class="macromolecule" id="s3463_sa1610" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly (ADP-ribose) polymerase 3 HUGO:PARP3, HGNC:273, ENTREZ:10039, UNIPROT:Q9Y6F1 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:REGULATORS MODULE:SPINDLE_CHECKPOINT MODULE:HR MODULE:C_NHEJ Maps_Modules_end References_begin: PMID:22055391 PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1 PMID:21270334 PARPs in cellular functions (PARP3 in telomere maintenance) PMID:22713970, PMID:21270334 PARP3 in HR and C_NHEJ PMID:22469522, PMID:196269035 PARP3 in chromatin remodeling PMID:22469522, PMID:22713970 APLF and PARP3 in C_NHEJ PMID:21211721‎ PMID:23178593 PMID:18077224‎ PARP3 in C_NHEJ PMID:22743550 References_end</body> </html> </notes> <label text="PARP3"/> <clone/> <bbox w="80.0" h="40.0" x="5843.3145" y="7453.3184"/> </glyph> <glyph class="macromolecule" id="s3464_sa165" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <clone/> <bbox w="80.0" h="40.0" x="7203.6064" y="7997.9985"/> <glyph class="state variable" id="_234cef47-be87-4997-baa6-a1c288bda867"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7237.354" y="7992.9985"/> </glyph> </glyph> <glyph class="macromolecule" id="s3464_sa1605" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Werner syndrome, RecQ helicase-like HUGO:WRN, HGNC:12791, ENTREZ:7486, UNIPROT:Q14191 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:BER MODULE:A_NHEJ MODULE:HR Maps_Modules_end References_begin: PMID:20691907 For A_NHEJ pathway (alt_NHEJ or B_NHEJ or MMEJ) PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 , PMID:21376743, PMID:24050180, PMID:22743550 For HR pathway PMID:19490890, PMID:22657828 For BER pathway PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013 WRN in telomere maintenance PMID:23253856 Resolving stalled replication fork Inhibiting WNT kills alt_NHEJ pathway PMID:24036544 PARP1 inhibits WRN PMID:23082994 WRN inhibits C_NHEJ by sequestering DNA-PKs PMID:12202749 Activation of WRN in cancers http://www.intechopen.com/download/get/type/pdfs/id/22156 http://www.intechopen.com/download/get/type/pdfs/id/19301 PMID:18524993 References_end</body> </html> </notes> <label text="WRN"/> <clone/> <bbox w="80.0" h="40.0" x="6496.307" y="6985.423"/> <glyph class="state variable" id="_335079de-d9fe-4433-85a5-7366bd23da34"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6530.0547" y="6980.423"/> </glyph> </glyph> <glyph class="macromolecule" id="s3465_sa229" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <clone/> <bbox w="80.0" h="40.0" x="9975.198" y="6768.423"/> <glyph class="state variable" id="_74453df8-a199-4035-aaf9-7649040bdaa6"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9964.182" y="6763.423"/> </glyph> <glyph class="state variable" id="_c9c6706c-4274-492e-97f8-0026d0e0c6bd"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9955.198" y="6783.423"/> </glyph> <glyph class="state variable" id="_da7f27c0-dcc7-415a-ae67-f7e3ace562e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9993.63" y="6803.423"/> </glyph> <glyph class="state variable" id="_928be910-98d2-480f-9e5e-816ec0b68af0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9970.198" y="6803.423"/> </glyph> <glyph class="state variable" id="_1fa19e84-241f-4584-8a0c-33647b0a4627"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10010.198" y="6803.423"/> </glyph> </glyph> <glyph class="macromolecule" id="s3465_sa1450" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA, HGNC:8729, ENTREZ:5111, UNIPROT:P12004 Identifiers_end Maps_Modules_begin: MODULE:DNA_REPAIR MODULE:NER MODULE:BER MODULE:MMR MODULE:TLS Maps_Modules_end References_begin: PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013 References_end</body> </html> </notes> <label text="PCNA"/> <clone/> <bbox w="80.0" h="40.0" x="9801.491" y="7081.6113"/> <glyph class="state variable" id="_32659e65-37a4-4b30-bb4f-16fd93008142"> <state value="" variable="K127"/> <bbox w="30.0" h="10.0" x="9790.475" y="7076.6113"/> </glyph> <glyph class="state variable" id="_f699ae68-c6a8-4720-b7c4-62a30e7e411b"> <state value="Ub" variable="K164"/> <bbox w="40.0" h="10.0" x="9781.491" y="7096.6113"/> </glyph> <glyph class="state variable" id="_f989f16c-b7ce-46ac-89e9-6d1891f42d8e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9819.923" y="7116.6113"/> </glyph> <glyph class="state variable" id="_8d6b7ed5-db93-4249-b69f-b9137444c7a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9796.491" y="7116.6113"/> </glyph> <glyph class="state variable" id="_e1948f01-c958-421d-9014-4ba69c1bac1d"> <state value="" variable=""/> <bbox 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id="pr_02711355-cbfd-44ee-95ed-2452546ed36e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: 9-1-1 complex activates Lig1 and BER PMID:15871698, PMID:16731526 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2923.334" y="7836.1606"/> <port id="pr_02711355-cbfd-44ee-95ed-2452546ed36e_p1" x="2928.334" y="7826.1606"/> <port id="pr_02711355-cbfd-44ee-95ed-2452546ed36e_p2" x="2928.334" y="7856.1606"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_192d18f7-55d6-4d54-b261-a575d651c4af"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18398454 PMID:16449207 RECQL5 activates BER via XRCC1 and PARP1 PMID:22973052 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15485915 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5415.5176" y="2855.334"/> <port id="pr_63a856c0-d610-47d1-a992-0c572d788640_p1" x="5420.5176" y="2845.334"/> <port id="pr_63a856c0-d610-47d1-a992-0c572d788640_p2" x="5420.5176" y="2875.334"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ad2b3c58-992d-4b27-bc45-02a8c8983bcf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19788416 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3394.428" y="2259.9915"/> <port id="pr_ad2b3c58-992d-4b27-bc45-02a8c8983bcf_p1" x="3399.428" y="2249.9915"/> <port 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id="pr_dab9e3b1-6c24-4720-b903-91d07cd8cb1d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11972333 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2367.4336" y="6916.802"/> <port id="pr_dab9e3b1-6c24-4720-b903-91d07cd8cb1d_p1" x="2357.4336" y="6921.802"/> <port id="pr_dab9e3b1-6c24-4720-b903-91d07cd8cb1d_p2" x="2387.4336" y="6921.802"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6cf9f491-3e21-44ee-a76b-b0342e27f1f7"> <bbox w="10.0" h="10.0" x="3570.2622" y="6736.8877"/> <port id="pr_6cf9f491-3e21-44ee-a76b-b0342e27f1f7_p1" x="3560.2622" y="6741.8877"/> <port id="pr_6cf9f491-3e21-44ee-a76b-b0342e27f1f7_p2" x="3590.2622" y="6741.8877"/> </glyph> <glyph class="process" orientation="vertical" id="pr_adc5e630-7172-48ef-a888-86edcd5b1672"> <bbox w="10.0" h="10.0" x="5761.0635" y="2258.1711"/> <port id="pr_adc5e630-7172-48ef-a888-86edcd5b1672_p1" x="5766.0635" y="2248.1711"/> <port id="pr_adc5e630-7172-48ef-a888-86edcd5b1672_p2" x="5766.0635" y="2278.1711"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f737282c-a40d-4dea-b1bf-60acec943103"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16731533 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5279.8403" y="6896.6904"/> <port id="pr_f737282c-a40d-4dea-b1bf-60acec943103_p1" x="5299.8403" y="6901.6904"/> <port id="pr_f737282c-a40d-4dea-b1bf-60acec943103_p2" x="5269.8403" y="6901.6904"/> </glyph> <glyph class="or" orientation="vertical" id="logicglyph_061526a9-0522-41f1-a8b8-de4bc39cf1dd"> <bbox w="20.0" h="20.0" x="4994.8306" y="5490.772"/> <port id="logicglyph_061526a9-0522-41f1-a8b8-de4bc39cf1dd_p1" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: kegg cell cycle References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5245.7324" y="1333.377"/> <port id="pr_ec25d5ee-75e0-411c-b80c-d896e01ccd7a_p1" x="5250.7324" y="1323.377"/> <port id="pr_ec25d5ee-75e0-411c-b80c-d896e01ccd7a_p2" x="5250.7324" y="1353.377"/> </glyph> <glyph class="process" orientation="vertical" id="pr_05bca193-61ab-48b3-8fed-1724648a5f9f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C and stops cell cycle propagation kegg cell cycle PMID:20126263, PMID:17568790 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4654.788" y="1335.377"/> <port id="pr_05bca193-61ab-48b3-8fed-1724648a5f9f_p1" x="4659.788" y="1355.377"/> <port id="pr_05bca193-61ab-48b3-8fed-1724648a5f9f_p2" x="4659.788" y="1325.377"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1663a03a-1335-46d5-be4d-ded0bfb1f928"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C and stops cell cycle propagation kegg cell cycle PMID:20126263, PMID:17568790 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4935.006" y="1334.877"/> <port id="pr_1663a03a-1335-46d5-be4d-ded0bfb1f928_p1" x="4940.006" y="1354.877"/> <port id="pr_1663a03a-1335-46d5-be4d-ded0bfb1f928_p2" x="4940.006" y="1324.877"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bcb06d07-1d8e-4de3-bb15-fa64384edd90"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18971944 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2376.334" y="7922.8384"/> <port id="pr_bcb06d07-1d8e-4de3-bb15-fa64384edd90_p1" x="2396.334" y="7927.8384"/> <port id="pr_bcb06d07-1d8e-4de3-bb15-fa64384edd90_p2" x="2366.334" y="7927.8384"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_53fee1a8-2894-4919-ba32-2e8fbbaa9a6c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: For inactivation of EXO1 by 53BP1-mediated phosphorylation: PMID:18756267, 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</head> <body>References_begin: PMID:15867354 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7607.465" y="6254.6797"/> <port id="pr_428bf88d-2b75-4d0c-af94-69c347f4d91f_p1" x="7612.465" y="6244.6797"/> <port id="pr_428bf88d-2b75-4d0c-af94-69c347f4d91f_p2" x="7612.465" y="6274.6797"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8f97e98b-2929-417a-a018-e51d46b09a95"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17129768 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2155.4321" y="6809.9053"/> <port id="pr_8f97e98b-2929-417a-a018-e51d46b09a95_p1" x="2175.4321" y="6814.9053"/> <port id="pr_8f97e98b-2929-417a-a018-e51d46b09a95_p2" x="2145.4321" y="6814.9053"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c9d04de0-61a2-49f6-83af-5f21c8efb822"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17129768 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="-1570043.0" y="-43284.984"/> <port id="pr_c9d04de0-61a2-49f6-83af-5f21c8efb822_p1" x="-1570038.0" y="-43294.984"/> <port id="pr_c9d04de0-61a2-49f6-83af-5f21c8efb822_p2" x="-1570038.0" y="-43264.984"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_28b9ff50-52de-49ff-a503-f915cda67642"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17129768 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3266.3154" y="6796.8516"/> <port id="pr_28b9ff50-52de-49ff-a503-f915cda67642_p1" x="3286.3154" y="6801.8516"/> <port id="pr_28b9ff50-52de-49ff-a503-f915cda67642_p2" x="3256.3154" y="6801.8516"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5a74c745-c8ce-4810-9a85-c8089b55c7dc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17129768 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2158.9214" y="6606.382"/> <port id="pr_5a74c745-c8ce-4810-9a85-c8089b55c7dc_p1" x="2178.9214" y="6611.382"/> <port id="pr_5a74c745-c8ce-4810-9a85-c8089b55c7dc_p2" x="2148.9214" y="6611.382"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_67004d5c-cb7f-4432-bdcd-4a10872e872c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19772495 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5741.421" y="6666.2324"/> <port id="pr_67004d5c-cb7f-4432-bdcd-4a10872e872c_p1" x="5761.421" y="6671.2324"/> <port id="pr_67004d5c-cb7f-4432-bdcd-4a10872e872c_p2" x="5731.421" y="6671.2324"/> </glyph> <glyph class="process" orientation="vertical" id="pr_11dedb67-971f-4ece-bb7c-b9a6ee415b47"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ: PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5476.9736" y="6712.141"/> <port id="pr_11dedb67-971f-4ece-bb7c-b9a6ee415b47_p1" x="5481.9736" y="6702.141"/> <port id="pr_11dedb67-971f-4ece-bb7c-b9a6ee415b47_p2" x="5481.9736" y="6732.141"/> </glyph> <glyph class="process" orientation="vertical" id="pr_57f49a6c-e93b-434a-b4eb-6abd41144308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PoLL in C_NHEJ: PMID:16738138 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5476.9736" y="7500.994"/> <port id="pr_57f49a6c-e93b-434a-b4eb-6abd41144308_p1" x="5481.9736" y="7490.994"/> <port id="pr_57f49a6c-e93b-434a-b4eb-6abd41144308_p2" x="5481.9736" y="7520.994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e1f2c2c2-bbff-4496-aabd-d39c942ff052"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21376743 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6180.159" y="7400.895"/> <port id="pr_e1f2c2c2-bbff-4496-aabd-d39c942ff052_p1" x="6170.159" y="7405.895"/> <port id="pr_e1f2c2c2-bbff-4496-aabd-d39c942ff052_p2" x="6200.159" y="7405.895"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ebefd39-aab7-48bb-8a5b-c4ed6d79d93e"> <bbox w="10.0" h="10.0" x="6032.1445" y="7400.9077"/> <port id="pr_0ebefd39-aab7-48bb-8a5b-c4ed6d79d93e_p1" x="6052.1445" y="7405.9077"/> <port id="pr_0ebefd39-aab7-48bb-8a5b-c4ed6d79d93e_p2" x="6022.1445" y="7405.9077"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ed42826-ed9e-426e-b523-fdc0c1f4d058"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9242410 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5762.597" y="7770.098"/> <port id="pr_0ed42826-ed9e-426e-b523-fdc0c1f4d058_p1" x="5782.597" y="7775.098"/> <port id="pr_0ed42826-ed9e-426e-b523-fdc0c1f4d058_p2" x="5752.597" y="7775.098"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_475138e5-e431-4f4f-9556-5ddc02e0cc85"> <bbox w="10.0" h="10.0" x="6014.4307" y="7770.29"/> <port id="pr_475138e5-e431-4f4f-9556-5ddc02e0cc85_p1" x="6034.4307" y="7775.29"/> <port id="pr_475138e5-e431-4f4f-9556-5ddc02e0cc85_p2" x="6004.4307" y="7775.29"/> </glyph> <glyph class="process" orientation="vertical" id="pr_365f4a8a-dd24-4031-b3df-d24d522fed5a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9488723, PMID:19772495 PMID:17303408 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6307.5186" y="2255.7039"/> <port id="pr_365f4a8a-dd24-4031-b3df-d24d522fed5a_p1" x="6312.5186" y="2275.7039"/> <port id="pr_365f4a8a-dd24-4031-b3df-d24d522fed5a_p2" x="6312.5186" y="2245.7039"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1a2226f4-1bf7-4faa-a0e7-e34dcaceec9a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MRN complex: PMID:16531125, PMID:17303408 Double strand breaks sensor. MRN complex association is a first event after the DNA damage. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7445.4014" y="5618.7"/> <port id="pr_1a2226f4-1bf7-4faa-a0e7-e34dcaceec9a_p1" x="7465.4014" y="5623.7"/> <port id="pr_1a2226f4-1bf7-4faa-a0e7-e34dcaceec9a_p2" x="7435.4014" y="5623.7"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0d83059a-3383-4be8-9819-3dbd2e852f76"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16310392 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6307.5186" y="2255.7039"/> <port id="pr_0d83059a-3383-4be8-9819-3dbd2e852f76_p1" x="6312.5186" y="2245.7039"/> <port id="pr_0d83059a-3383-4be8-9819-3dbd2e852f76_p2" x="6312.5186" y="2275.7039"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4ce0123a-17a8-48cc-bfa4-8bb112169758"> <bbox w="10.0" h="10.0" x="6284.854" y="4995.4814"/> <port id="pr_4ce0123a-17a8-48cc-bfa4-8bb112169758_p1" x="6289.854" y="5015.4814"/> <port id="pr_4ce0123a-17a8-48cc-bfa4-8bb112169758_p2" x="6289.854" y="4985.4814"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_36090b2d-6e68-44bf-a07c-017ddb062038"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16093244 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6069.1445" y="7459.4077"/> <port id="pr_36090b2d-6e68-44bf-a07c-017ddb062038_p1" x="6089.1445" y="7464.4077"/> <port id="pr_36090b2d-6e68-44bf-a07c-017ddb062038_p2" x="6059.1445" y="7464.4077"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_398bfe50-dfe1-4c44-88f3-eeffc2d72df0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11955432, PMID:19772495 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5807.171" y="7449.7236"/> <port id="pr_398bfe50-dfe1-4c44-88f3-eeffc2d72df0_p1" x="5827.171" y="7454.7236"/> <port id="pr_398bfe50-dfe1-4c44-88f3-eeffc2d72df0_p2" x="5797.171" y="7454.7236"/> </glyph> <glyph class="process" orientation="vertical" id="pr_50fd527b-fb87-49aa-b4aa-8be2b8004fed"> <bbox w="10.0" h="10.0" x="5476.9736" y="7769.994"/> <port id="pr_50fd527b-fb87-49aa-b4aa-8be2b8004fed_p1" x="5481.9736" y="7759.994"/> <port id="pr_50fd527b-fb87-49aa-b4aa-8be2b8004fed_p2" x="5481.9736" y="7789.994"/> </glyph> <glyph class="process" orientation="vertical" id="pr_49372f35-33ae-453a-892a-e68da0ea73c4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17303408, PMID:16163361, PMID:15964794 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7180.8916" y="5704.4814"/> <port id="pr_49372f35-33ae-453a-892a-e68da0ea73c4_p1" x="7185.8916" y="5724.4814"/> <port id="pr_49372f35-33ae-453a-892a-e68da0ea73c4_p2" x="7185.8916" y="5694.4814"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e5d068da-0c94-4b54-b78e-bf0026789982"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: 9-1-1 complex activates FEN and BER PMID:15871698, PMID:16216273 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2923.334" y="7538.292"/> <port id="pr_e5d068da-0c94-4b54-b78e-bf0026789982_p1" x="2928.334" y="7528.292"/> <port id="pr_e5d068da-0c94-4b54-b78e-bf0026789982_p2" x="2928.334" y="7558.292"/> </glyph> <glyph class="process" orientation="vertical" id="pr_74ee4113-ee71-4cba-b6de-fbc5ff99ba93"> <bbox w="10.0" h="10.0" x="4072.5972" y="6950.581"/> <port id="pr_74ee4113-ee71-4cba-b6de-fbc5ff99ba93_p1" x="4077.5972" y="6970.581"/> <port id="pr_74ee4113-ee71-4cba-b6de-fbc5ff99ba93_p2" x="4077.5972" y="6940.581"/> </glyph> <glyph class="process" orientation="vertical" id="pr_caba786a-fc14-4f5f-9f1d-1fefe79d43d2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224 For inhibition of A_NHEJ by DNA-PKs: PMID:15211575 For stimulation of A_NHEJ by PARP1: PMID:15498778, PMID:19362533, PMID:24050180 For role of MRN complex in A_NHEJ: PMID:19654615, PMID:19892829 BLM inhibits A_NHEJ (alt_NHEJ): PMID:24089143 PMID:24095737 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6300.926" y="6703.636"/> <port id="pr_caba786a-fc14-4f5f-9f1d-1fefe79d43d2_p1" x="6305.926" y="6693.636"/> <port id="pr_caba786a-fc14-4f5f-9f1d-1fefe79d43d2_p2" x="6305.926" y="6723.636"/> </glyph> <glyph class="process" orientation="vertical" id="pr_80f0ebc0-b126-4a62-9542-0b16ba8bd221"> <bbox w="10.0" h="10.0" x="6369.665" y="5505.1426"/> <port id="pr_80f0ebc0-b126-4a62-9542-0b16ba8bd221_p1" x="6374.665" y="5495.1426"/> <port id="pr_80f0ebc0-b126-4a62-9542-0b16ba8bd221_p2" x="6374.665" y="5525.1426"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_477c98db-941e-405f-9ed2-dfaab32abaeb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation by ATM and ATR at T847, S327 Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267 This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ. PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983 BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop): PMID:20051983 Only when CDKs are fully active, this fully activates HR during S and G2 phases: PMID:18511906, PMID:18716619 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6024.6436" y="2165.0"/> <port id="pr_477c98db-941e-405f-9ed2-dfaab32abaeb_p1" x="6014.6436" y="2170.0"/> <port id="pr_477c98db-941e-405f-9ed2-dfaab32abaeb_p2" x="6044.6436" y="2170.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b42e6f9f-87c8-43e6-9009-327c925cfb03"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14654780 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5931.1436" y="2258.5"/> <port id="pr_b42e6f9f-87c8-43e6-9009-327c925cfb03_p1" x="5936.1436" y="2248.5"/> <port id="pr_b42e6f9f-87c8-43e6-9009-327c925cfb03_p2" x="5936.1436" y="2278.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cb4ab938-6826-4b3d-951a-6cf3d4e95311"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14654780 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5953.34" y="2620.25"/> <port id="pr_cb4ab938-6826-4b3d-951a-6cf3d4e95311_p1" x="5958.34" y="2610.25"/> <port id="pr_cb4ab938-6826-4b3d-951a-6cf3d4e95311_p2" x="5958.34" y="2640.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_27d26ba6-487d-4a92-a385-08babe7b01bb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18171670 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7203.972" y="5676.714"/> <port id="pr_27d26ba6-487d-4a92-a385-08babe7b01bb_p1" x="7223.972" y="5681.714"/> <port id="pr_27d26ba6-487d-4a92-a385-08babe7b01bb_p2" x="7193.972" y="5681.714"/> </glyph> <glyph class="process" orientation="vertical" id="pr_80e0d799-4b44-4eaa-8038-3139c4a6c523"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18171670, PMID:20064462 For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928 The complex BRCA2:FANCC:FANCG:XRCC3 activates HR: PMID:18212739 For role of BLM:TOP3:RMI1 complex in the HR resection step: PMID:19490890 For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ: PMID:20021983 For inhibition of HR by RECQ5: PMID:19270065 For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation: PMID:15655342, PMID:15549137, PMID:15496928 RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR: PMID:18001825 SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS PMID:19217833 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6793.832" y="5845.387"/> <port id="pr_80e0d799-4b44-4eaa-8038-3139c4a6c523_p1" x="6798.832" y="5835.387"/> <port id="pr_80e0d799-4b44-4eaa-8038-3139c4a6c523_p2" x="6798.832" y="5865.387"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a921c3f5-efac-4183-830b-1530b3362282"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16581787, For inhibition of S-checkpoint by ATM: PMID:15175241 Inhibition of Sphase by MRE complex: PMID:17713585 By CycE*/CDK2: G1/S transition By CycD*/CDK2/CIp/KIP: checkpoint G1/S References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4693.566" y="4175.0"/> <port id="pr_a921c3f5-efac-4183-830b-1530b3362282_p1" x="4683.566" y="4180.0"/> <port id="pr_a921c3f5-efac-4183-830b-1530b3362282_p2" x="4713.566" y="4180.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_89114a25-75c4-4c86-86e8-c07f25ebb1bf"> <bbox w="20.0" h="20.0" x="5509.0" y="5115.8335"/> <port id="logicglyph_89114a25-75c4-4c86-86e8-c07f25ebb1bf_p1" x="5519.0" y="5145.8335"/> <port id="logicglyph_89114a25-75c4-4c86-86e8-c07f25ebb1bf_p2" x="5519.0" y="5105.8335"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5650ca93-1ec5-421c-b30b-d736c40aad7e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint PMID:16818604 PMID:19357644 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6118.2686" y="2255.5"/> <port id="pr_5650ca93-1ec5-421c-b30b-d736c40aad7e_p1" x="6123.2686" y="2245.5"/> <port id="pr_5650ca93-1ec5-421c-b30b-d736c40aad7e_p2" x="6123.2686" y="2275.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_49721f5e-c97a-4900-989e-58b21fd3b101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: For inhibition of S-checkpoint by ATM: PMID:15175241, PMID:12086603 For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex: PMID:19282663, PMID:19622404, PMID:18995830 For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion): PMID:18469862 Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2: PMID:20051983, PMID:16805667 For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP: PMID:19342888 ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated: PMID:16713580 For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase: PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221 For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex: PMID:19793801, PMID:17384638 For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint PMID:15798197 Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton: PMID:14988723, PMID:15136767 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5094.3877" y="4177.0"/> <port id="pr_49721f5e-c97a-4900-989e-58b21fd3b101_p1" x="5084.3877" y="4182.0"/> <port id="pr_49721f5e-c97a-4900-989e-58b21fd3b101_p2" x="5114.3877" y="4182.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_0b794cf3-2023-4869-be2e-dc52fc1bf99a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: By CycB*/CDC2*: G2/M transition PMID:16818604 For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis: PMID:15375219, PMID:19686080 CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation PMID:15377654 Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint) PMID:16818604, PMID:15485915 BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint). PMID:15242590 FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition): PMID:18995830 ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair: PMID:16713580, PMID:18543256 BER and MMR interaction and G2/M arrest inresponce to o6-meG formation: PMID:14614141 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5080.7695" y="4504.0"/> <port id="pr_0b794cf3-2023-4869-be2e-dc52fc1bf99a_p1" x="5100.7695" y="4509.0"/> <port id="pr_0b794cf3-2023-4869-be2e-dc52fc1bf99a_p2" x="5070.7695" y="4509.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_25e08f8e-1a0d-4255-a967-c790b561e0f5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644 PMID:15485915 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7509.8076" y="6214.395"/> <port id="pr_25e08f8e-1a0d-4255-a967-c790b561e0f5_p1" x="7514.8076" y="6234.395"/> <port id="pr_25e08f8e-1a0d-4255-a967-c790b561e0f5_p2" x="7514.8076" y="6204.395"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e0d67019-6031-4a14-ab96-e2764f1075c2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20064462, MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6350.576" y="5651.6426"/> <port id="pr_e0d67019-6031-4a14-ab96-e2764f1075c2_p1" x="6355.576" y="5641.6426"/> <port id="pr_e0d67019-6031-4a14-ab96-e2764f1075c2_p2" x="6355.576" y="5671.6426"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6023480b-0a72-42d4-8bc5-03015226ebca"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18584027:G, PMID:17965729, PMID:20064462, PMID:18809224 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6300.926" y="6991.509"/> <port id="pr_6023480b-0a72-42d4-8bc5-03015226ebca_p1" x="6305.926" y="6981.509"/> <port id="pr_6023480b-0a72-42d4-8bc5-03015226ebca_p2" x="6305.926" y="7011.509"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_177e01f1-84a2-41d4-9861-12b8cf0d317b"> <bbox w="10.0" h="10.0" x="5136.824" y="7183.379"/> <port id="pr_177e01f1-84a2-41d4-9861-12b8cf0d317b_p1" x="5126.824" y="7188.379"/> <port id="pr_177e01f1-84a2-41d4-9861-12b8cf0d317b_p2" x="5156.824" y="7188.379"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a234c801-1607-47ac-9183-83b685fc2f12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18584027:G, PMID:17965729, PMID:20064462, PMID:18809224 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6300.926" y="7225.9824"/> <port id="pr_a234c801-1607-47ac-9183-83b685fc2f12_p1" x="6305.926" y="7215.9824"/> <port id="pr_a234c801-1607-47ac-9183-83b685fc2f12_p2" x="6305.926" y="7245.9824"/> </glyph> <glyph class="process" orientation="vertical" id="pr_857fb3a3-e879-46d3-9e12-f8b3534a7299"> <bbox w="10.0" h="10.0" x="6300.926" y="7493.6035"/> <port id="pr_857fb3a3-e879-46d3-9e12-f8b3534a7299_p1" x="6305.926" y="7483.6035"/> <port id="pr_857fb3a3-e879-46d3-9e12-f8b3534a7299_p2" x="6305.926" y="7513.6035"/> </glyph> <glyph class="process" orientation="vertical" id="pr_067bca06-57bc-4183-a0fa-dddb5ad22924"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Involvement of LigIII/XRCC1 in A_NHEJ together with PARP1 PMID:19362533, PMID:21376743, PMID:24050180, PMID:22743550 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6300.926" y="7769.994"/> <port id="pr_067bca06-57bc-4183-a0fa-dddb5ad22924_p1" x="6305.926" y="7759.994"/> <port id="pr_067bca06-57bc-4183-a0fa-dddb5ad22924_p2" x="6305.926" y="7789.994"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_909e127e-79f6-4032-bf7a-c4ae4c8cb91e"> <bbox w="10.0" h="10.0" x="6726.756" y="7927.411"/> <port id="pr_909e127e-79f6-4032-bf7a-c4ae4c8cb91e_p1" x="6746.756" y="7932.411"/> <port id="pr_909e127e-79f6-4032-bf7a-c4ae4c8cb91e_p2" x="6716.756" y="7932.411"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7a0fb4fd-ba14-47b6-889c-d62a09067b8b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18809224 Complex RNF8:MDC1 ubiquitinates Ku80 and causes it's dissociation from DNA and degradation.This bring to shift from C_NHEJ to HR: PMID:18001825, PMID:18678709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5910.3945" y="6686.7046"/> <port id="pr_7a0fb4fd-ba14-47b6-889c-d62a09067b8b_p1" x="5900.3945" y="6691.7046"/> <port id="pr_7a0fb4fd-ba14-47b6-889c-d62a09067b8b_p2" x="5930.3945" y="6691.7046"/> </glyph> <glyph class="process" orientation="vertical" id="pr_92001b2d-eda0-4632-919c-56e9dc7a3701"> <bbox w="10.0" h="10.0" x="6072.166" y="6913.659"/> <port id="pr_92001b2d-eda0-4632-919c-56e9dc7a3701_p1" x="6077.166" y="6903.659"/> <port 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formation regulation by UBc13: PMID:17349954 For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination: PMID:19841479, PMID:19793861, PMID:19793862 MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair PMID:22771115 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6793.832" y="7005.909"/> <port id="pr_d46e9091-8cbd-4a89-9c2b-da1b5ca3c6d2_p1" x="6798.832" y="6995.909"/> <port id="pr_d46e9091-8cbd-4a89-9c2b-da1b5ca3c6d2_p2" x="6798.832" y="7025.909"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f5ca86aa-cb62-4025-9e3a-1e526b4249b7"> <bbox w="10.0" h="10.0" x="7682.237" y="7074.964"/> <port id="pr_f5ca86aa-cb62-4025-9e3a-1e526b4249b7_p1" x="7702.237" y="7079.964"/> <port id="pr_f5ca86aa-cb62-4025-9e3a-1e526b4249b7_p2" x="7672.237" y="7079.964"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5f37f13c-08ab-45cf-a539-d3a34fe76994"> <bbox w="10.0" h="10.0" x="7672.467" y="7124.3926"/> <port id="pr_5f37f13c-08ab-45cf-a539-d3a34fe76994_p1" x="7677.467" y="7144.3926"/> <port id="pr_5f37f13c-08ab-45cf-a539-d3a34fe76994_p2" x="7677.467" y="7114.3926"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4e62ccc4-7ddb-459f-b975-089c494fdb2b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19686080 POLH participates in the D-loop formation in HR: PMID:16337602, PMID:16337601 Complex PolN:HEL308 participates in HR and in Fanconi PMID:19995904 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6793.832" y="7636.6523"/> <port id="pr_4e62ccc4-7ddb-459f-b975-089c494fdb2b_p1" x="6798.832" y="7626.6523"/> <port id="pr_4e62ccc4-7ddb-459f-b975-089c494fdb2b_p2" x="6798.832" y="7656.6523"/> </glyph> <glyph class="process" orientation="vertical" 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y="7677.3926"/> <port id="pr_0b95eda5-d31c-4ef1-96c2-7741ded57e63_p1" x="7276.0938" y="7667.3926"/> <port id="pr_0b95eda5-d31c-4ef1-96c2-7741ded57e63_p2" x="7276.0938" y="7697.3926"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1a535f42-77ce-40af-8ca3-253bfa278ecc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: For role of SNM1B in Fanconi and S-phase checkpoint PMID:18469862 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7303.381" y="8296.943"/> <port id="pr_1a535f42-77ce-40af-8ca3-253bfa278ecc_p1" x="7323.381" y="8301.943"/> <port id="pr_1a535f42-77ce-40af-8ca3-253bfa278ecc_p2" x="7293.381" y="8301.943"/> </glyph> <glyph class="process" orientation="vertical" id="pr_97ec3725-b26f-4ad8-a347-b74f79dfb142"> <bbox w="10.0" h="10.0" x="6793.832" y="8227.493"/> <port 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PMID:19686080 For ERCC1/XPF: PMID:10882712, PMID:19805513 For MUS81/Eme1: PMID:17036055:G FANCA modulates XPF function: MRN complex, FANCD2 and SNM1B are modulators of the DNA to release stalled fork: PMD:19622404 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8429.611" y="7067.005"/> <port id="pr_2fe6fec5-fed5-4b52-bb4a-e54e92590eff_p1" x="8434.611" y="7057.005"/> <port id="pr_2fe6fec5-fed5-4b52-bb4a-e54e92590eff_p2" x="8434.611" y="7087.005"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_3e8456e3-c13e-4dcf-8d03-aa193a6f1c32"> <bbox w="20.0" h="20.0" x="8530.614" y="7403.168"/> <port id="logicglyph_3e8456e3-c13e-4dcf-8d03-aa193a6f1c32_p1" x="8540.614" y="7433.168"/> <port id="logicglyph_3e8456e3-c13e-4dcf-8d03-aa193a6f1c32_p2" x="8540.614" y="7393.168"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4cc8b3c4-2002-4552-8cf7-03634fbdd0ee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19686080 POLH activates D-loop extention PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR: PMID:16337602 Presence of FA core complex is essential for thePolZ/Rev1 activity: PMID:18448394 PoLQ/HEL308 in Fancon: PMID:18472307 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8429.611" y="7460.0723"/> <port id="pr_4cc8b3c4-2002-4552-8cf7-03634fbdd0ee_p1" x="8434.611" y="7450.0723"/> <port id="pr_4cc8b3c4-2002-4552-8cf7-03634fbdd0ee_p2" x="8434.611" y="7480.0723"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_530e90bc-e6a1-4540-a1d4-6679c9294bd8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Link between Fanconi pathway and NER. Fanconi pathway is a coordination of NER, TLS and HR PMID:19686080, PMID:22615860 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4564.634" y="7547.736"/> <port id="pr_530e90bc-e6a1-4540-a1d4-6679c9294bd8_p1" x="4584.634" y="7552.736"/> <port id="pr_530e90bc-e6a1-4540-a1d4-6679c9294bd8_p2" x="4554.634" y="7552.736"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c4fa2d34-5d9a-472f-aee5-3c19570392d9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Link between Fanconi pathway and HR. Fanconi pathway is a coordination of NER, TLS and HR PMID:19686080:G POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR: PMID:16337602 For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination: PMID:19841479, PMID:19793861, PMID:19793862 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7611.7217" y="6928.9746"/> <port id="pr_c4fa2d34-5d9a-472f-aee5-3c19570392d9_p1" x="7631.7217" y="6933.9746"/> <port id="pr_c4fa2d34-5d9a-472f-aee5-3c19570392d9_p2" x="7601.7217" y="6933.9746"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_817b9e41-31b8-4350-a982-77d55f11bbe7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins. PMID:19686080 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7391.9873" y="7457.8584"/> <port id="pr_817b9e41-31b8-4350-a982-77d55f11bbe7_p1" x="7411.9873" y="7462.8584"/> <port id="pr_817b9e41-31b8-4350-a982-77d55f11bbe7_p2" x="7381.9873" y="7462.8584"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a1127dcb-8c8d-4390-98bc-bf1b025d51ed"> <bbox w="10.0" h="10.0" x="7493.699" y="7123.6426"/> <port id="pr_a1127dcb-8c8d-4390-98bc-bf1b025d51ed_p1" x="7498.699" y="7113.6426"/> <port id="pr_a1127dcb-8c8d-4390-98bc-bf1b025d51ed_p2" x="7498.699" y="7143.6426"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d461c5c9-1c48-4b48-871f-60e776c4aa09"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18157158 Ubiquitination of PCNA by RAD6-RAD18 increases affinity of PCNA to POLH and makes switch from PCNA-POLD to PCNA-POLH and stops translation and initiates TLS pathway PMID:15280666, PMID:18498753 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8936.418" y="7047.4224"/> <port id="pr_d461c5c9-1c48-4b48-871f-60e776c4aa09_p1" x="8926.418" y="7052.4224"/> <port id="pr_d461c5c9-1c48-4b48-871f-60e776c4aa09_p2" x="8956.418" y="7052.4224"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f574b18f-09bd-4dad-87a1-3d583ed35daa"> <bbox w="10.0" h="10.0" x="9821.922" y="6612.091"/> <port id="pr_f574b18f-09bd-4dad-87a1-3d583ed35daa_p1" x="9841.922" y="6617.091"/> <port id="pr_f574b18f-09bd-4dad-87a1-3d583ed35daa_p2" x="9811.922" y="6617.091"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d26607dc-16db-4722-b5b4-fd0d63e6925f"> <bbox w="10.0" h="10.0" x="9692.797" y="6820.1865"/> <port id="pr_d26607dc-16db-4722-b5b4-fd0d63e6925f_p1" x="9712.797" y="6825.1865"/> <port id="pr_d26607dc-16db-4722-b5b4-fd0d63e6925f_p2" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: reactionType:is.a References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4258.965" y="6158.744"/> <port id="pr_f77e0978-f585-4ae0-a9c0-2bb8391e4d34_p1" x="4248.965" y="6163.744"/> <port id="pr_f77e0978-f585-4ae0-a9c0-2bb8391e4d34_p2" x="4278.965" y="6163.744"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7c54e46f-5211-4a2a-afac-32d885f9a9d8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation PMID:17035102 Several TLS polymerases participate in Fanconi in combination with HR and NER PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta: PMID:15189446, PMID:12466554 (major) Depending on the DNA damage, different TLS polymerases will be activated: PMID:19225445 REV1 interacts with many TLS polymerases: PMID:14657033 Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass PMID:19217833, PMID:18157158, For TLS PMID:19258535 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4779.235" y="6980.7495"/> <port id="pr_7c54e46f-5211-4a2a-afac-32d885f9a9d8_p1" x="4784.235" y="6970.7495"/> <port id="pr_7c54e46f-5211-4a2a-afac-32d885f9a9d8_p2" x="4784.235" y="7000.7495"/> </glyph> <glyph class="process" orientation="vertical" id="pr_520d38e8-4cfa-4544-9752-56ca1e0ef095"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS PMID:19217833, PMID:18157158, PMID:19851286 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7622.8477" y="6335.5537"/> <port id="pr_520d38e8-4cfa-4544-9752-56ca1e0ef095_p1" x="7627.8477" y="6355.5537"/> <port id="pr_520d38e8-4cfa-4544-9752-56ca1e0ef095_p2" x="7627.8477" y="6325.5537"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_705bc312-edba-4fa6-a055-fcf560e95dad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19851286 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9353.045" y="6850.1455"/> <port id="pr_705bc312-edba-4fa6-a055-fcf560e95dad_p1" x="9343.045" y="6855.1455"/> <port id="pr_705bc312-edba-4fa6-a055-fcf560e95dad_p2" x="9373.045" y="6855.1455"/> </glyph> <glyph class="process" orientation="vertical" 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cycle and DNA damage-dependent manner. 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</head> <body>References_begin: PMID:18931676, PMID:19686080 Link between cell cycle and activation of Fanconi pathway References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9307.202" y="8054.191"/> <port id="pr_372a20aa-68c2-4102-ae05-075844b453d9_p1" x="9327.202" y="8059.191"/> <port id="pr_372a20aa-68c2-4102-ae05-075844b453d9_p2" x="9297.202" y="8059.191"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9c491419-7945-45ec-aefd-d32abe490e9f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18931676, PMID:19686080 Link between cell cycle and activation of Fanconi pathway NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex: PMID:14988723 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7845.723" y="6769.159"/> <port 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PMID:19264559 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9488.972" y="7367.5205"/> <port id="pr_d52f9f7d-0f61-4efa-ab27-71f410cad30a_p1" x="9478.972" y="7372.5205"/> <port id="pr_d52f9f7d-0f61-4efa-ab27-71f410cad30a_p2" x="9508.972" y="7372.5205"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7785b51b-4bd6-470d-95b9-7a6b92584374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis. PMID:19270156, PMID:19686080 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8970.614" y="6506.025"/> <port id="pr_7785b51b-4bd6-470d-95b9-7a6b92584374_p1" x="8960.614" y="6511.025"/> <port id="pr_7785b51b-4bd6-470d-95b9-7a6b92584374_p2" x="8990.614" y="6511.025"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fd67147f-71f0-42fd-a0e5-2d12899aab8a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis. PMID:19270156 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9136.122" y="6719.275"/> <port id="pr_fd67147f-71f0-42fd-a0e5-2d12899aab8a_p1" x="9141.122" y="6709.275"/> <port id="pr_fd67147f-71f0-42fd-a0e5-2d12899aab8a_p2" x="9141.122" y="6739.275"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c679a21f-a548-4968-9937-16338a92b5af"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TDG SUMOlation causes dissociation of TDG from DNA to allow the next step of BER pathway by APE proteins. PMID:16626738 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3443.7568" y="6848.1387"/> <port id="pr_c679a21f-a548-4968-9937-16338a92b5af_p1" x="3433.7568" y="6853.1387"/> <port id="pr_c679a21f-a548-4968-9937-16338a92b5af_p2" x="3463.7568" y="6853.1387"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ef3ab34c-735d-4755-813d-ce56c3285d1c"> <bbox w="10.0" h="10.0" x="3572.5066" y="7075.355"/> <port id="pr_ef3ab34c-735d-4755-813d-ce56c3285d1c_p1" x="3577.5066" y="7065.355"/> <port id="pr_ef3ab34c-735d-4755-813d-ce56c3285d1c_p2" x="3577.5066" y="7095.355"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6a17d792-a0e3-406c-8c35-c0d88f89a94c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR. PMID:12086603 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8026.1353" y="6759.159"/> <port id="pr_6a17d792-a0e3-406c-8c35-c0d88f89a94c_p1" x="8016.1353" y="6764.159"/> <port id="pr_6a17d792-a0e3-406c-8c35-c0d88f89a94c_p2" x="8046.1353" y="6764.159"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_60344251-e0a0-477b-8d46-ccbbdcbe2781"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase: PMID:19282663, PMID:19622404, PMID:18995830 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6607.3926" y="4561.1006"/> <port id="pr_60344251-e0a0-477b-8d46-ccbbdcbe2781_p1" x="6627.3926" y="4566.1006"/> <port id="pr_60344251-e0a0-477b-8d46-ccbbdcbe2781_p2" x="6597.3926" y="4566.1006"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e18bf7d6-e2e1-4939-8d35-6c0db48d38c2"> <bbox w="10.0" h="10.0" x="8663.426" y="8074.962"/> <port id="pr_e18bf7d6-e2e1-4939-8d35-6c0db48d38c2_p1" x="8668.426" y="8064.962"/> <port id="pr_e18bf7d6-e2e1-4939-8d35-6c0db48d38c2_p2" x="8668.426" y="8094.962"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9f6b5131-befe-4729-a197-5b9b78550d00"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The complex activates HR PMID:18212739 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7204.506" y="5890.158"/> <port id="pr_9f6b5131-befe-4729-a197-5b9b78550d00_p1" x="7224.506" y="5895.158"/> <port id="pr_9f6b5131-befe-4729-a197-5b9b78550d00_p2" x="7194.506" y="5895.158"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_db61b381-cc15-46ff-81f7-58e95585d368"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15242590 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7331.862" y="6704.8076"/> <port id="pr_db61b381-cc15-46ff-81f7-58e95585d368_p1" x="7351.862" y="6709.8076"/> <port id="pr_db61b381-cc15-46ff-81f7-58e95585d368_p2" x="7321.862" y="6709.8076"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d537faf7-f46f-4b81-ba25-ff837044c421"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint PMID:15136767, PMID:14988723 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7616.478" y="5544.454"/> <port id="pr_d537faf7-f46f-4b81-ba25-ff837044c421_p1" x="7636.478" y="5549.454"/> <port id="pr_d537faf7-f46f-4b81-ba25-ff837044c421_p2" x="7606.478" y="5549.454"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d0e479b1-87f7-4d1f-84e3-e0f7467a0bea"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint PMID:15136767 Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation: PMID:14988723 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6021.097" y="4728.063"/> <port id="pr_d0e479b1-87f7-4d1f-84e3-e0f7467a0bea_p1" x="6041.097" y="4733.063"/> <port id="pr_d0e479b1-87f7-4d1f-84e3-e0f7467a0bea_p2" x="6011.097" y="4733.063"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_61d9d7e6-23e5-4b45-8cac-d65225b101cb"> <bbox w="10.0" h="10.0" x="7536.7227" y="6982.7256"/> <port id="pr_61d9d7e6-23e5-4b45-8cac-d65225b101cb_p1" x="7526.7227" y="6987.7256"/> <port id="pr_61d9d7e6-23e5-4b45-8cac-d65225b101cb_p2" x="7556.7227" y="6987.7256"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5034c53d-a89a-4aa6-8f92-738717e77737"> <bbox w="10.0" h="10.0" x="8059.0977" y="6981.72"/> <port id="pr_5034c53d-a89a-4aa6-8f92-738717e77737_p1" x="8049.0977" y="6986.72"/> <port id="pr_5034c53d-a89a-4aa6-8f92-738717e77737_p2" x="8079.0977" y="6986.72"/> </glyph> <glyph class="process" orientation="vertical" id="pr_42ce29f7-1c39-4aec-b661-d1a85205adb8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion): PMID:18469862 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5768.7676" y="5098.3384"/> <port id="pr_42ce29f7-1c39-4aec-b661-d1a85205adb8_p1" x="5773.7676" y="5118.3384"/> <port id="pr_42ce29f7-1c39-4aec-b661-d1a85205adb8_p2" x="5773.7676" y="5088.3384"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0dd5cd64-39b8-4100-b5d0-d3c7ab287191"> <bbox w="10.0" h="10.0" x="7115.756" y="7745.1865"/> <port id="pr_0dd5cd64-39b8-4100-b5d0-d3c7ab287191_p1" x="7135.756" y="7750.1865"/> <port id="pr_0dd5cd64-39b8-4100-b5d0-d3c7ab287191_p2" x="7105.756" y="7750.1865"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dd2a9694-c544-4a29-950b-f1a6d52e6070"> <bbox w="10.0" h="10.0" x="8307.756" y="7700.4785"/> <port id="pr_dd2a9694-c544-4a29-950b-f1a6d52e6070_p1" x="8297.756" y="7705.4785"/> <port id="pr_dd2a9694-c544-4a29-950b-f1a6d52e6070_p2" x="8327.756" y="7705.4785"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e1bea92e-6805-4135-b083-ceb90093c7e6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PolN is degraded after S-phase by G2/M cell cycle checkpoint PMID:19995904 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7299.0527" y="7940.75"/> <port id="pr_e1bea92e-6805-4135-b083-ceb90093c7e6_p1" x="7304.0527" y="7930.75"/> <port id="pr_e1bea92e-6805-4135-b083-ceb90093c7e6_p2" x="7304.0527" y="7960.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3bc8e7b7-0b6c-4255-8198-e3116627572e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19264559 FANCL induces UBE2T auto-ubiquitination on Lys91 by this inactivating UBE2T. 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If the cell is in S/G2 phase, HR will take place. 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NER at the level of DNA damage recognition involving GADD45, XPC, DDB2: PMID:12771027, PMID:9346961 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7867.0186" y="1559.7533"/> <port id="pr_5260e355-5cf9-4a72-b5cd-0156222f1dda_p1" x="7857.0186" y="1564.7533"/> <port id="pr_5260e355-5cf9-4a72-b5cd-0156222f1dda_p2" x="7887.0186" y="1564.7533"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_040a6a19-b90e-4f93-a373-f6b179d9af31"> <bbox w="10.0" h="10.0" x="4812.9023" y="4108.253"/> <port id="pr_040a6a19-b90e-4f93-a373-f6b179d9af31_p1" x="4832.9023" y="4113.253"/> <port id="pr_040a6a19-b90e-4f93-a373-f6b179d9af31_p2" x="4802.9023" y="4113.253"/> </glyph> <glyph class="process" orientation="vertical" id="pr_758926a3-a94b-42a0-85db-960956bf4d3a"> <bbox w="10.0" h="10.0" x="5667.5107" y="4108.462"/> <port id="pr_758926a3-a94b-42a0-85db-960956bf4d3a_p1" x="5672.5107" y="4098.462"/> <port id="pr_758926a3-a94b-42a0-85db-960956bf4d3a_p2" x="5672.5107" 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y="6620.768"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_60749726-2a14-4610-bebd-950756a7755a"> <bbox w="10.0" h="10.0" x="1366.3069" y="7895.332"/> <port id="pr_60749726-2a14-4610-bebd-950756a7755a_p1" x="1386.3069" y="7900.332"/> <port id="pr_60749726-2a14-4610-bebd-950756a7755a_p2" x="1356.3069" y="7900.332"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1573c359-4b6b-4cb3-9722-4b03c743f660"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: BRIT1*/E2F1 complex activates BRCA1 and CHEK1 transcription during S-phase and G2/M checkpoints: PMID:15220350, PMID:18660752, PMID:20376879 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7866.2686" y="1691.2509"/> <port id="pr_1573c359-4b6b-4cb3-9722-4b03c743f660_p1" x="7856.2686" y="1696.2509"/> <port 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polymerases will be activated: PMID:19225445 REV1 interacts with many TLS polymerases: PMID:14657033 Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass PMID:19217833, PMID:18157158 For TLS PMID:19258535 FA core complex regulates REV1 and activated TLS PMID:22266823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9367.768" y="6506.0"/> <port id="pr_feae2587-b919-48f2-b4de-b4955046bdc6_p1" x="9372.768" y="6496.0"/> <port id="pr_feae2587-b919-48f2-b4de-b4955046bdc6_p2" x="9372.768" y="6526.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_f7459844-9050-4553-aedd-d309d37da05a"> <bbox w="20.0" h="20.0" x="9136.667" y="7337.1665"/> <port id="logicglyph_f7459844-9050-4553-aedd-d309d37da05a_p1" x="9146.667" y="7367.1665"/> <port id="logicglyph_f7459844-9050-4553-aedd-d309d37da05a_p2" x="9146.667" y="7327.1665"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f295b007-fe7f-4065-97bb-c5f7acb5616f"> <bbox w="10.0" 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damage in DNA that repared by NER pathway PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527 Transcription-dependent NER and damage by UV PMID:20045328, PMID:14599741 Interstrand crosslinking agents induce NER PMID:21701511 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2506.1704" y="6160.8564"/> <port id="pr_5b58aef2-49de-4f31-9164-7ed5e0421e55_p1" x="2526.1704" y="6165.8564"/> <port id="pr_5b58aef2-49de-4f31-9164-7ed5e0421e55_p2" x="2496.1704" y="6165.8564"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_093338fb-3bba-4bcd-90f1-9f4c69995a40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: http://dnatraffic.ibb.waw.pl/classification/dna_damages For Fanconi PMID:17145857 Fanconi is activated by interstrand crosslinking agents PMID:23444773, PMID:21948210, PMID:21701511 Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways PMID:23259582 For HR PMID:22123462, PMID:20693240 PMID:21414716, PMID:23157317 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6640.5654" y="5987.548"/> <port id="pr_093338fb-3bba-4bcd-90f1-9f4c69995a40_p1" x="6630.5654" y="5992.548"/> <port id="pr_093338fb-3bba-4bcd-90f1-9f4c69995a40_p2" x="6660.5654" y="5992.548"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_475fe518-0cb7-41ec-81e3-c87b39eec229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents PMID:22869732 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8097.225" y="7058.099"/> <port 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