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</glyph> <glyph class="macromolecule" id="s5_sa5" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:6307 Synonyms : FLK1, VEGFR, VEGFR2, CD309 PMID:16076871</body> </html> </notes> <label text="KDR"/> <bbox w="80.0" h="50.0" x="735.0" y="345.0"/> <glyph class="state variable" id="_59b51835-e4aa-4d23-b06b-702bbf8f50f8"> <state value="" variable="1054"/> <bbox w="30.0" h="10.0" x="742.9755" y="390.0"/> </glyph> <glyph class="state variable" id="_efb8dfcf-ec60-469d-8303-d3bc1f17e543"> <state value="" variable="Y1175"/> <bbox w="35.0" h="10.0" x="773.83057" y="390.0"/> </glyph> <glyph class="unit of information" id="_d2957524-c277-49e6-8edc-10742c325198"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="752.5" y="340.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s7_sa7" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8005 PMID:25922287;PMID:24217602 comments: (NRP)1 and NRP2 are VEGF coreceptors. NRP1 is expressed by blood endothelial cells whereas NRP2 is expressed by venous and lymphatic endothelial cells</body> </html> </notes> <label text="NRP2"/> <bbox w="80.0" h="40.0" x="1605.0" y="130.0"/> </glyph> <glyph class="macromolecule" id="s8_sa8" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:3763 synonyms : VEGFR1 PMID:16076871</body> </html> </notes> <label text="FLT1"/> <bbox w="80.0" h="50.0" x="455.0" y="345.0"/> <glyph class="unit of information" id="_f65a2ad9-b198-4ecc-a991-d88446b6ad36"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="472.5" y="340.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s9_sa9" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8893 synonyms: PGFL, "placental growth factor, vascular endothelial growth factor-related protein", "placental growth factor-like"</body> </html> </notes> <label text="PGF"/> <bbox w="80.0" h="40.0" x="265.0" y="160.0"/> </glyph> <glyph class="macromolecule" id="s10_sa11" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:3767 synonyms:PCL, VEGFR3 PMID:16076871</body> </html> </notes> <label text="FLT4"/> <bbox w="80.0" h="50.0" x="1527.5" y="342.5"/> <glyph class="state variable" id="_d9b607b6-abaf-44e8-a11e-eac2bb48480b"> <state value="" variable="Y1337"/> <bbox w="35.0" h="10.0" x="1547.8419" y="387.5"/> </glyph> <glyph class="state variable" id="_537003ca-6475-40a0-b0a7-0dc8b2640254"> <state value="" variable="Y1063"/> 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:5464 PMID:17145802</body> </html> </notes> <label text="IGF1"/> <bbox w="80.0" h="40.0" x="3785.0" y="1600.0"/> </glyph> <glyph class="macromolecule" id="s16_sa17" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:17145802 HGNC:5466</body> </html> </notes> <label text="IGF2"/> <bbox w="80.0" h="40.0" x="3885.0" y="1640.0"/> </glyph> <glyph class="macromolecule" id="s17_sa18" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:5465 PMID:17145802</body> </html> </notes> <label text="IGF1R"/> <bbox w="80.0" h="50.0" x="3715.0" y="1815.0"/> <glyph 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of information" id="_791b5502-73e1-463c-b1f6-451d0ffc7ae0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3732.5" y="700.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s22_sa238" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8803 PMID:17145802</body> </html> </notes> <label text="PDGFRA"/> <bbox w="80.0" h="50.0" x="3712.5" y="657.5"/> <glyph class="unit of information" id="_9f84ebaa-0f05-4640-8dca-6594048db2ff"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3730.0" y="652.5"/> </glyph> </glyph> <glyph class="complex" id="s23_csa1" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:25922287</body> </html> </notes> <label text="s23"/> <bbox w="182.0" h="121.0" x="542.0" y="297.0"/> <glyph class="macromolecule" id="s24_sa24"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:3763 synonyms : VEGFR1 PMID:16076871</body> </html> </notes> <label text="FLT1"/> <bbox w="80.0" h="50.0" x="632.0" y="353.0"/> <glyph class="unit of information" id="_8b858fd3-dfc1-4680-86e9-c41bfe20df11"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="649.5" y="348.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s26_sa25"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8004 PMID:25922287;PMID:24217602 comments: Neuropilin (NRP)1 and NRP2 are VEGF coreceptors. NRP1 is expressed by blood endothelial cells whereas NRP2 is expressed by venous and lymphatic endothelial cells. The coreceptor neuropilin (NRP)1 is expressed by BECs and boosts the affinity of VEGF-A165a for VEGFR-2</body> </html> </notes> <label text="NRP1"/> <bbox w="80.0" h="40.0" x="548.0" y="355.0"/> </glyph> <glyph class="macromolecule" id="s639_sa516"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:12680 PMID:22064427</body> </html> </notes> <label text="VEGFA"/> <bbox w="80.0" h="40.0" x="548.4545" y="301.81818"/> </glyph> <glyph class="macromolecule" id="s640_sa517"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:VEGFB HGNC:12681 Identifiers_end Maps_Modules_begin: MODULE: Maps_Modules_end References_begin: PMID:22064427 References_end</body> </html> </notes> <label text="VEGFB"/> <bbox w="80.0" h="40.0" x="626.4545" y="304.81818"/> </glyph> </glyph> <glyph class="complex" id="s29_csa2" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:25922287</body> </html> </notes> <label text="s29"/> <bbox w="190.0" h="120.0" x="820.0" y="290.0"/> <glyph class="macromolecule" id="s318_sa29"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8004 PMID:25922287;PMID:24217602 comments: Neuropilin (NRP)1 and NRP2 are VEGF coreceptors. NRP1 is expressed by blood endothelial cells whereas NRP2 is expressed by venous and lymphatic endothelial cells. The coreceptor neuropilin (NRP)1 is expressed by BECs and boosts the affinity of VEGF-A165a for VEGFR-2</body> </html> </notes> <label text="NRP1"/> <bbox w="80.0" h="40.0" x="830.0" y="340.0"/> </glyph> <glyph class="macromolecule" id="s319_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:6307 Synonyms : FLK1, VEGFR, VEGFR2, CD309 PMID:16076871</body> </html> </notes> <label text="KDR"/> <bbox w="80.0" h="50.0" x="925.0" y="345.0"/> <glyph class="state variable" id="_3484158e-dc82-49bf-85a3-5c8219252a8c"> <state value="" variable="1054"/> <bbox w="30.0" h="10.0" x="932.9755" y="390.0"/> </glyph> <glyph class="state variable" id="_3abc80d2-20c4-4231-ab1f-19b109840b41"> <state value="" variable="Y1175"/> <bbox w="35.0" h="10.0" x="963.83057" y="390.0"/> </glyph> <glyph class="unit of information" id="_57d98af3-8d2a-48db-8f28-712b46c1dd9f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="942.5" y="340.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s637_sa513"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:12682 PMID:22064427</body> </html> </notes> <label text="VEGFC"/> <bbox w="80.0" h="40.0" x="830.4545" y="293.81818"/> </glyph> <glyph class="macromolecule" id="s638_sa514"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:3708 Previous name : VEGFD PMID:22064427</body> </html> </notes> <label text="FIGF"/> <bbox w="80.0" h="40.0" x="903.4545" y="295.81818"/> </glyph> </glyph> <glyph class="complex" id="s49_csa6" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:25922287 PMID: 11532940</body> </html> </notes> <label text="s49"/> <bbox w="180.0" h="115.0" x="1615.0" y="302.5"/> <glyph class="macromolecule" id="s154_sa32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8005 PMID:25922287;PMID:24217602 comments: (NRP)1 and NRP2 are VEGF coreceptors. 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xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:484 Synonyms: Ang1 PMID:19223473</body> </html> </notes> <label text="ANGPT1"/> <bbox w="80.0" h="40.0" x="3490.8125" y="304.375"/> </glyph> <glyph class="macromolecule" id="s105_sa88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:484 Synonyms: Ang1 PMID:19223473</body> </html> </notes> <label text="ANGPT1"/> <bbox w="80.0" h="40.0" x="3493.8125" y="317.375"/> </glyph> <glyph class="macromolecule" id="s108_sa90"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:4566 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<title/> </head> <body>PMID:19223473 PMID:19449109 Comments:Ang2 is both an agonist and an antagonist of Tie2. 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h="40.0" x="2994.0" y="2115.5"/> </glyph> </glyph> <glyph class="complex" id="s142_csa16" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:19449109</body> </html> </notes> <label text="s142"/> <bbox w="200.0" h="115.0" x="3195.0" y="832.5"/> <glyph class="macromolecule" id="s138_sa118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>synonyms:p110D HGNC:8977</body> </html> </notes> <label text="PIK3CD"/> <bbox w="80.0" h="40.0" x="3305.0" y="882.5"/> </glyph> <glyph class="macromolecule" id="s139_sa119"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:CASP9 Identifiers_end References_begin: PMID:9812896 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="3363.0" y="1354.0"/> <glyph class="state variable" id="_3fbdf73a-6702-425e-94c9-8a95b0d4b494"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3412.0686" y="1349.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="s150_sa128" compartmentRef="c2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:BIRC5 Identifiers_end</body> </html> </notes> <label text="Survivin*"/> <bbox w="70.0" h="25.0" x="3104.0" y="2243.0"/> </glyph> <glyph class="nucleic acid feature" id="s151_sa129" compartmentRef="c2_ca2"> <notes> <html 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id="_279eccaa-5595-412a-a38f-7786873db414"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1878.75" y="320.3125"/> </glyph> </glyph> <glyph class="macromolecule" id="s161_sa137"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:3767 synonyms:PCL, VEGFR3 PMID:16076871</body> </html> </notes> <label text="FLT4"/> <bbox w="80.0" h="50.0" x="1871.25" y="335.3125"/> <glyph class="state variable" id="_be8366c8-d388-4b7e-bf3d-336653d787f5"> <state value="P" variable="Y1337"/> <bbox w="40.0" h="10.0" x="1889.0919" y="380.3125"/> </glyph> <glyph class="state variable" id="_f927dd17-658a-40ae-b6b9-240517f3e0e4"> <state value="P" variable="Y1063"/> <bbox w="40.0" h="10.0" x="1931.25" y="337.1392"/> </glyph> <glyph class="state variable" id="_3a0f56c5-f73c-46ff-8b40-554519ac81df"> <state value="P" variable="Y1230"/> <bbox w="40.0" h="10.0" x="1851.25" y="338.04996"/> </glyph> <glyph class="unit of information" id="_93f0aa4e-b164-4b5a-a08a-bd13ddbc6700"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1888.75" y="330.3125"/> </glyph> </glyph> <glyph class="macromolecule" id="s52_sa131"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8005 PMID:25922287;PMID:24217602 comments: (NRP)1 and NRP2 are VEGF coreceptors. 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class="macromolecule" id="s396_sa339"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:10840 Synonyms:SHC, p66, ShcA PMID:19449109 PMID:16076871</body> </html> </notes> <label text="SHC1"/> <bbox w="80.0" h="40.0" x="1960.0" y="445.0"/> </glyph> <glyph class="macromolecule" id="s397_sa341"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:CRKL PMID:16076871</body> </html> </notes> <label text="CRKL"/> <bbox w="80.0" h="40.0" x="1860.0" y="445.0"/> </glyph> <glyph class="macromolecule" id="s650_sa528"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:10840 Synonyms:SHC, p66, ShcA PMID:19449109 PMID:16076871</body> </html> </notes> <label text="SHC1"/> <bbox w="80.0" h="40.0" x="2885.0" y="555.0"/> </glyph> <glyph class="macromolecule" id="s471_sa406"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:4566 PMID:19449109;16076871</body> </html> </notes> <label text="GRB2"/> <bbox w="80.0" h="40.0" x="2885.0" y="605.0"/> </glyph> <glyph class="macromolecule" id="s475_sa409"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:SOS1 HUGO:SOS2</body> </html> </notes> <label text="SOS*"/> <bbox w="80.0" h="40.0" x="2885.0" y="655.0"/> </glyph> </glyph> <glyph class="simple chemical" id="s202_sa186" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:23747852 PMID:11324699 PMID:15258919 PMID: 15801912 Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions.</body> </html> </notes> <label text="Lysophosphatic acid"/> <bbox w="145.0" h="22.5" x="479.5" y="1423.75"/> </glyph> <glyph class="macromolecule" id="s204_sa179" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Lysophosphatidic acid receptors HUGO:LPAR1, HUGO:LPAR2, HUGO:LPAR3, HUGO:LPAR4, HUGO:LPAR5, HUGO:LPAR6 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compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:11324699 PMID:15258919</body> </html> </notes> <label text="phosphatidic acid"/> <bbox w="125.0" h="32.5" x="489.5" y="1148.75"/> </glyph> <glyph class="macromolecule" id="s218_sa191" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:11324699 PMID:15258919</body> </html> </notes> <label text="PLA1A"/> <bbox w="80.0" h="40.0" x="422.0" y="1255.0"/> </glyph> <glyph class="macromolecule" id="s219_sa192" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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y="1495.0"/> </glyph> <glyph class="simple chemical" id="s230_sa204" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:23747852 PMID:11324699 PMID:15258919 PMID:19066402</body> </html> </notes> <label text="Lysophosphatic acid"/> <bbox w="145.0" h="22.5" x="62.5" y="1208.75"/> </glyph> <glyph class="simple chemical" id="s231_sa205" compartmentRef="c1_ca1"> <label text="Lysophosphatidylcohine"/> <bbox w="195.0" h="32.5" x="624.5" y="1588.75"/> </glyph> <glyph class="simple chemical" id="s232_sa206" compartmentRef="c1_ca1"> <label text="H2O"/> <bbox w="70.0" h="25.0" x="672.0" y="1477.5"/> </glyph> <glyph class="macromolecule" id="s233_sa207" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:ENPP2 HGNC:3357 PMID:11324699 PMID:15258919</body> </html> </notes> <label text="Autotaxin*"/> <bbox w="80.0" h="40.0" x="772.0" y="1525.0"/> </glyph> <glyph class="macromolecule" id="s235_sa209" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Lipid phosphate phosphatases HUGO:PLPP1, HUGO:PLPP2, HUGO:PLPP3, HUGO:PLPP4, HUGO:PLPP5, HUGO:PLPP6, HUGO:PLPP7 Identifiers_end References_begin: PMID:11324699 PMID:15258919 References_end</body> </html> </notes> <label text="LPP*"/> <bbox w="80.0" h="40.0" x="205.0" y="1170.0"/> </glyph> <glyph class="simple chemical" id="s228_sa202" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:24838 Identifiers_end</body> </html> </notes> <label text="Inorganic phosphate"/> <clone/> <bbox w="125.0" h="32.5" x="399.5" y="1568.75"/> </glyph> <glyph class="simple chemical" id="s228_sa253" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CHEBI:24838 Identifiers_end</body> </html> </notes> <label text="Inorganic phosphate"/> <clone/> <bbox w="135.0" h="32.5" x="1774.5" y="2395.75"/> </glyph> <glyph class="simple chemical" id="s236_sa211" compartmentRef="c4_ca4"> <label text="Inorganic phosphate"/> <bbox w="70.0" h="25.0" x="50.0" y="1117.5"/> </glyph> <glyph class="simple chemical" id="s237_sa210" compartmentRef="c4_ca4"> 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class="macromolecule" id="s248_sa224" compartmentRef="c1_ca1"> <label text="AGPAT5"/> <bbox w="80.0" h="40.0" x="822.0" y="1205.0"/> </glyph> <glyph class="macromolecule" id="s249_sa225" compartmentRef="c4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:S1PR1 22975327</body> </html> </notes> <label text="S1PR1"/> <bbox w="80.0" h="50.0" x="851.0" y="2591.0"/> <glyph class="unit of information" id="_62bba0e5-6da6-4c26-8192-90f49c6adcf4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="868.5" y="2586.0"/> </glyph> </glyph> <glyph class="complex" id="s253_csa21" compartmentRef="c4_ca4"> <label text="s253"/> <bbox w="190.0" h="100.0" x="406.0" y="2576.0"/> <glyph class="simple chemical" id="s255_sa227"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:S1PR3 PMID:22975327</body> </html> </notes> <label text="S1PR3"/> <bbox w="80.0" h="50.0" x="961.0" y="2601.0"/> <glyph class="unit of information" id="_ba9ce25a-afff-4ab2-84ed-d1497c69e728"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="978.5" y="2596.0"/> </glyph> </glyph> <glyph class="phenotype" id="s261_sa234" compartmentRef="c1_ca1"> <label text="Quiescence of vasculature"/> <bbox w="180.0" h="35.0" x="2125.0" y="1812.5"/> </glyph> <glyph class="complex" id="s266_csa22" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID: 26366398</body> </html> </notes> <label text="s266"/> <bbox w="150.0" h="130.0" x="3720.0" y="1315.0"/> <glyph class="macromolecule" id="s267_sa236"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:7029 Synonyms:DFNB97, "hepatocyte growth factor receptor", HGFR, RCCP2 PMID:17145802 PMID: 26366398</body> </html> </notes> <label text="MET"/> <bbox w="80.0" h="50.0" x="3730.0" y="1370.0"/> <glyph class="unit of information" id="_d723d8e5-bf61-432e-b358-214fe9e90d12"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3747.5" y="1365.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s268_sa237"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:4893 PMID:17145802 PMID:26366398</body> </html> </notes> <label text="HGF"/> <bbox w="80.0" h="40.0" x="3780.0" y="1335.0"/> </glyph> </glyph> <glyph class="complex" 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y="805.0"/> <glyph class="unit of information" id="_81b0a2ac-00d8-4784-a22a-818d54a473a6"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3712.5" y="800.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s278_csa24" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:17145802</body> </html> </notes> <label text="s271"/> <bbox w="190.0" h="120.0" x="3685.0" y="1000.0"/> <glyph class="macromolecule" id="s281_sa240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8800 PMID:17145802</body> </html> </notes> <label text="PDGFB"/> <bbox w="80.0" h="40.0" x="3785.0" y="1030.0"/> </glyph> <glyph class="macromolecule" id="s279_sa241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8804 PMID:17145802</body> </html> </notes> <label text="PDGFRB"/> <bbox w="80.0" h="50.0" x="3697.5" y="1052.5"/> <glyph class="unit of information" id="_9938c2c9-696c-4d29-b49c-a7e0c0015a50"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3715.0" y="1047.5"/> </glyph> </glyph> <glyph class="macromolecule" id="s280_sa242"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8803 PMID:17145802</body> </html> </notes> <label text="PDGFRA"/> <bbox w="80.0" h="50.0" x="3695.0" y="1005.0"/> <glyph class="unit of information" id="_f4ac363d-3636-490d-9aa6-021ec12c6e73"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3712.5" y="1000.0"/> </glyph> 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compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:CD36 HGNC:1663 Synonyms:"CD36 antigen (collagen type I receptor, thrombospondin receptor)" PMID:?2015-MOJCSR-02-00015 PMID:21378271</body> </html> </notes> <label text="CD36"/> <bbox w="80.0" h="50.0" x="205.0" y="545.0"/> <glyph class="unit of information" id="_4a62a462-fc6a-492d-99fe-1b5bad0dee01"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="222.5" y="540.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s299_sa262" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:CD47 HGNC:1682 PMID:?2015-MOJCSR-02-00015</body> </html> </notes> <label text="CD47"/> <bbox w="80.0" h="50.0" x="195.0" y="815.0"/> <glyph class="unit of information" id="_2c4ec925-609a-4988-87c1-6ce20938320f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="212.5" y="810.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s300_sa258" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:THBS1 Identifiers_end</body> </html> </notes> <label text="TSP*"/> <bbox w="80.0" h="40.0" x="535.0" y="740.0"/> </glyph> <glyph class="complex" id="s304_csa26" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:23896411</body> </html> </notes> <label text="s304"/> <bbox w="270.0" h="110.0" x="100.0" y="695.0"/> <glyph class="macromolecule" id="s332_sa255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:CD36 HGNC:1663 Synonyms:"CD36 antigen (collagen type I receptor, thrombospondin receptor)" PMID:?2015-MOJCSR-02-00015 PMID:21378271</body> </html> </notes> <label text="CD36"/> <bbox w="80.0" h="50.0" x="190.0" y="710.0"/> <glyph class="unit of information" id="_36184f79-b485-43a5-b855-c5a819401f75"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="207.5" y="705.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s333_sa259"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:THBS1 Identifiers_end</body> </html> </notes> <label text="TSP*"/> <bbox w="80.0" h="40.0" x="110.0" y="715.0"/> </glyph> <glyph class="macromolecule" id="s355_sa289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:SYK PMID:21378271</body> </html> </notes> <label text="SYK"/> <bbox w="80.0" h="40.0" x="280.0" y="705.0"/> <glyph class="state variable" id="_9d4db30d-981f-459e-9b2f-9065410c1904"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="331.56854" y="740.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s356_sa303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PTPN6 HGNC:9658 PMID:23896411</body> </html> </notes> <label text="SHP1*"/> <bbox w="80.0" h="40.0" x="270.0" y="755.0"/> </glyph> </glyph> <glyph class="complex" id="s307_csa27" 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x="112.5" y="927.5"/> </glyph> </glyph> <glyph class="phenotype" id="s309_sa263" compartmentRef="c1_ca1"> <label text="NOS Pathway"/> <bbox w="110.0" h="25.0" x="2150.0" y="1527.5"/> </glyph> <glyph class="complex" id="s312_csa28" compartmentRef="c1_ca1"> <label text="s312"/> <bbox w="180.0" h="120.0" x="635.0" y="760.0"/> <glyph class="macromolecule" id="s310_sa264"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:TNFSF10 Identifiers_end</body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="725.0" y="770.0"/> </glyph> <glyph class="macromolecule" id="s311_sa265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:TNFRSF10A, 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:TNFSF10 Identifiers_end</body> </html> </notes> <label text="TRAIL*"/> <bbox w="80.0" h="40.0" x="685.0" y="510.0"/> </glyph> <glyph class="macromolecule" id="s315_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:TNFRSF10A, HUGO:TNFRSF10A Identifiers_end</body> </html> </notes> <label text="DR4/5*"/> <bbox w="80.0" h="50.0" x="685.0" y="555.0"/> <glyph class="unit of information" id="_14d9e2c9-4679-4000-8ea0-4cdcdec6388d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="702.5" y="550.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="s321_csa30" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:25922287 PMID:23896411</body> </html> </notes> <label text="s29"/> <bbox w="205.0" h="130.0" x="1042.5" y="287.0"/> <glyph class="macromolecule" id="s361_sa269"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8004 PMID:25922287;PMID:24217602 comments: Neuropilin (NRP)1 and NRP2 are VEGF coreceptors. NRP1 is expressed by blood endothelial cells whereas NRP2 is expressed by venous and lymphatic endothelial cells. The coreceptor neuropilin (NRP)1 is expressed by BECs and boosts the affinity of VEGF-A165a for VEGFR-2</body> </html> </notes> <label text="NRP1"/> <bbox w="80.0" h="40.0" x="1052.5" y="347.0"/> </glyph> <glyph class="macromolecule" id="s349_sa270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:6307 Synonyms : FLK1, VEGFR, VEGFR2, CD309 PMID:16076871</body> </html> </notes> <label text="KDR"/> <bbox w="80.0" h="50.0" x="1142.5" y="352.0"/> <glyph class="state variable" id="_b94027f0-c88f-4d1a-a3fc-90a1ac3a7f40"> <state value="P" variable="1054"/> <bbox w="35.0" h="10.0" x="1147.9755" y="397.0"/> </glyph> <glyph class="state variable" id="_930e03ad-d67c-4281-8c73-4e000a7b1945"> <state value="" variable="Y1175"/> <bbox w="35.0" h="10.0" x="1181.3306" y="397.0"/> </glyph> <glyph class="unit of information" 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x="1175.0" y="337.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s641_sa518"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:12680 PMID:22064427</body> </html> </notes> <label text="VEGFA"/> <bbox w="80.0" h="40.0" x="1150.4546" y="291.81818"/> </glyph> <glyph class="macromolecule" id="s641_sa519"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:12680 PMID:22064427</body> </html> </notes> <label text="VEGFA"/> <bbox w="80.0" h="40.0" x="1160.4546" y="301.81818"/> </glyph> <glyph class="macromolecule" id="s643_sa520"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:VEGFB HGNC:12681 Identifiers_end Maps_Modules_begin: MODULE: Maps_Modules_end References_begin: PMID:22064427 References_end</body> </html> </notes> <label text="VEGFB"/> <bbox w="80.0" h="40.0" x="1067.4546" y="291.81818"/> </glyph> <glyph class="macromolecule" id="s643_sa521"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:VEGFB HGNC:12681 Identifiers_end Maps_Modules_begin: MODULE: Maps_Modules_end References_begin: PMID:22064427 References_end</body> </html> </notes> <label text="VEGFB"/> <bbox w="80.0" h="40.0" x="1081.4546" y="301.81818"/> </glyph> </glyph> <glyph class="macromolecule" id="s326_sa274" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PTPN6 HGNC:9658 PMID:23896411</body> </html> </notes> <label text="SHP1*"/> <bbox w="80.0" h="40.0" x="335.0" y="630.0"/> </glyph> <glyph class="macromolecule" id="s343_sa293" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:SYK PMID:21378271</body> </html> </notes> <label text="SYK"/> <clone/> <bbox w="80.0" h="40.0" x="1065.0" y="470.0"/> <glyph class="state variable" id="_f0135184-18f5-4811-aded-5fdf49db564f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1116.5686" y="505.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s343_sa302" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:4037 PMID:21378271</body> </html> </notes> <label text="SYN"/> <bbox w="80.0" h="40.0" x="405.0" y="680.0"/> <glyph class="state variable" id="_0e7eb9cb-7fc3-411d-acc2-29cf92af0ccf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="480.0" y="686.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="s354_sa300" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:4037 PMID:21378271</body> </html> </notes> <label text="SYN"/> <bbox w="80.0" h="40.0" x="405.0" y="780.0"/> <glyph class="state variable" id="_7da7eb36-d5ff-4f06-8614-62411fc36c68"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="477.5" y="786.7157"/> </glyph> </glyph> <glyph class="complex" id="s362_csa34" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:25922287 PMID:23896411</body> </html> </notes> <label text="s29"/> <bbox w="202.5" h="245.0" x="1303.75" y="277.5"/> <glyph class="macromolecule" id="s363_sa305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8004 PMID:25922287;PMID:24217602 comments: Neuropilin (NRP)1 and NRP2 are VEGF coreceptors. 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absent but as a dose-dependent antagonist when Ang1 is present</body> </html> </notes> <label text="s387"/> <bbox w="100.0" h="130.0" x="3025.0" y="305.0"/> <glyph class="macromolecule" id="s388_sa329"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:11724 Synonyms: CD202b, TIE-2, TIE2, VMCM1 PMID:11283723</body> </html> </notes> <label text="TEK"/> <bbox w="80.0" h="50.0" x="3035.0" y="360.0"/> <glyph class="state variable" id="_91880a0b-6aed-45b4-9cbf-eff07682c67f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3086.5686" y="405.0"/> </glyph> <glyph class="state variable" id="_aef9055c-8574-4e92-8d07-d12e409fefcf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3053.446" y="405.0"/> </glyph> <glyph class="state variable" id="_9c6e1804-8d0a-4f34-afe6-da525d3d84ba"> <state value="" variable=""/> <bbox w="10.0" 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Although Ang2 is a weaker agonist than Ang1, endogenous Ang2 maintains a level of Tie2 activation that is critical to a spectrum of EC functions Ang-2 levels are upregulated by hypoxia Davis S, Aldrich TH, Jones PF et al (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87:1161–1169. doi:10.1016/S0092-8674(00)81812-7</body> </html> </notes> <label text="ANGPT2"/> <bbox w="80.0" h="40.0" x="3035.0" y="315.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s392_sa335" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:19223473 PMID:19449109 Comments:Ang2 is both an agonist and an antagonist of Tie2. 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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:MAPK3 HGNC:6877 PMID:16076871 PMID:11335727</body> </html> </notes> <label text="ERK1*"/> <bbox w="80.0" h="40.0" x="1858.0" y="816.0"/> <glyph class="state variable" id="_48f5bc73-9e40-4012-b906-7b4313370d13"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1907.0686" y="811.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s407_sa350" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:MAPK1 HGNC:6871 PMID:16076871 PMID:11335727</body> </html> </notes> <label text="ERK2*"/> <bbox w="80.0" h="40.0" x="1858.0" y="876.0"/> <glyph class="state variable" id="_f8ff85cc-7429-40cb-9e9d-c2dedf987144"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1907.0686" y="871.0"/> </glyph> </glyph> <glyph class="complex" id="s410_csa38" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:16076871 VEGFR-2– and VEGFR-3–positive endothelial cells respond to VEGF-C or VEGF-D by forming functional heterodimers that would maintain elevated levels of survival signaling through Y1063, but attenuated endothelial-cell proliferation and spreading as the contribution of Y1337 would be missing</body> </html> </notes> <label text="s410"/> <bbox w="270.0" h="180.0" x="2180.0" y="290.0"/> <glyph class="macromolecule" id="s413_sa356"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:3767 synonyms:PCL, VEGFR3 PMID:16076871</body> </html> </notes> <label text="FLT4"/> <bbox 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y="410.0"/> </glyph> <glyph class="macromolecule" id="s416_sa361"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:CRKL PMID:16076871</body> </html> </notes> <label text="CRKL"/> <bbox w="80.0" h="40.0" x="2190.0" y="410.0"/> </glyph> <glyph class="macromolecule" id="s417_sa362"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HGNC:8005 PMID:25922287;PMID:24217602 comments: (NRP)1 and NRP2 are VEGF coreceptors. 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NRP1 is expressed by blood endothelial cells whereas NRP2 is expressed by venous and lymphatic endothelial cells. The coreceptor neuropilin (NRP)1 is expressed by BECs and boosts the affinity of VEGF-A165a for VEGFR-2</body> </html> </notes> <label text="NRP1"/> <bbox w="80.0" h="40.0" x="2359.5" y="357.16666"/> </glyph> </glyph> <glyph class="complex" id="s426_csa39" compartmentRef="c1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:11532940</body> </html> </notes> <label text="p85"/> <clone/> <bbox w="100.0" h="120.0" x="3125.0" y="590.0"/> <glyph class="macromolecule" id="s427_sa94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PIK3R1 HGNC:8979 synonyms:phosphoinositide-3-kinase, regulatory subunit 1 (alpha),GRB1, p85, p85-ALPHA PMID:19449109 PMID:11532940</body> </html> </notes> 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y="630.0"/> <glyph class="macromolecule" id="s427_sa367"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PIK3R1 HGNC:8979 synonyms:phosphoinositide-3-kinase, regulatory subunit 1 (alpha),GRB1, p85, p85-ALPHA PMID:19449109 PMID:11532940</body> </html> </notes> <label text="PIK3R1"/> <clone/> <bbox w="80.0" h="40.0" x="1295.0" y="640.0"/> <glyph class="state variable" id="_29553bed-011d-47b0-91d2-c091c9b7e40c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1346.5686" y="675.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s428_sa368"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:11532940</body> </html> </notes> <label text="PIK3R2"/> <clone/> <bbox w="80.0" h="40.0" x="1295.0" y="690.0"/> </glyph> </glyph> <glyph class="complex" id="s429_csa40" compartmentRef="c1_ca1"> <label text="p85*"/> <clone/> <bbox w="100.0" h="120.0" x="3275.0" y="590.0"/> <glyph class="macromolecule" id="s430_sa331"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PIK3R1 HGNC:8979 synonyms:phosphoinositide-3-kinase, regulatory subunit 1 (alpha),GRB1, p85, p85-ALPHA PMID:19449109 PMID:11532940</body> </html> </notes> <label text="PIK3R1"/> <clone/> <bbox w="80.0" h="40.0" x="3285.0" y="600.0"/> <glyph class="state variable" id="_31621e94-6ec2-4840-8795-fcd545bb360d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3334.0686" y="635.0"/> </glyph> </glyph> <glyph class="macromolecule" id="s431_sa365"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" 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